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Anti-aging Research > Statins
Note: Red yeast rice
is a non-prescription statin but check with your doctor first. See
red yeast rice at Amazon.com.
aristata combined with Silybum marianum on lipid profile in patients not
tolerating statins at high doses - Atherosclerosis. 2014 Dec 24 -
evaluate the effects of Berberis aristata combined with Silybum marianum in
dyslipidemic patients intolerant to statins at high doses ... B. aristata/S.
marianum reduced fasting plasma glucose (-9 mg/dl), insulin (-0.7 μU/ml), and
HOMA-index (-0.35) levels compared to baseline and also to placebo. Lipid
profile did not significantly change after 6 months since the reduction of
statin dosage and the introduction of B. aristata/S. marianum, while it worsened
in the placebo group both compared to placebo and with active treatment (+23.4
mg/dl for total cholesterol, +19.6 mg/dl for LDL-cholesterol, +23.1 mg/dl for
triglycerides with placebo compared to B. aristata/S. marianum). We did not
record any variations of safety parameters in nether of groups" - See
silymarin at Amazon.com
berberine at Amazon.com.
enhances cell-surface LDLR level and promotes LDL uptake through down-regulation
of PCSK9 gene expression in HepG2 cells - Mol Nutr Food Res. 2014 Aug 27 -
"Curcumin exhibits hypolipidemic activity and may serve
as a useful supplement to statin treatment for hypercholesterolemia" -
curcumin products at Amazon.com.
vitamin D on plasma lipid profiles in statin-treated patients with
hypercholesterolemia: A randomized placebo-controlled trial - Clin Nutr.
2014 May 2 - "Patients with hypercholesterolemia were
enrolled in this single-center, double-blind, placebo-controlled trial in
Beijing (39°54' N). Fifty-six patients were randomly assigned to receive vitamin
D (n = 28, 2000 IU/d) or a placebo (n = 28) as an add-on to statin ... At 6
months, the primary end point, a difference in the fall of serum total
cholesterol levels between the vitamin D and placebo groups after 6 months of
treatment was significant -22.1 mg/dl (95% CI -32.3; -12.2) (p < 0.001). The
difference between the groups in the fall of serum triglyceride levels after 6
months of treatment was -28.2 mg/dl (95% CI -48.8; -8.4) (p < 0.001)" -
vitamin D at Amazon.com.
effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap
fibroatheroma - Atherosclerosis. 2014 Mar 5;234(1):114-119 -
"The addition of highly purified eicosapentaenoic acid
(EPA) to statin therapy prevents cardiovascular events ... Patients were
randomly assigned to EPA (1800 mg/day) + statin (23 TCFA, 15 patients) or statin
only (26 TCFA, 15 patients) treatment. The statin (rosuvastatin) dose was
adjusted to achieve a target low-density lipoprotein (LDL) level of <70 mg/dL
... The concomitant use of EPA and rosuvastatin may stabilize vulnerable plaques
better than the statin alone, possibly by suppressing arterial inflammation"
fish oil supplements at Amazon.com.
supplementation improves metabolic parameters, liver function and mitochondrial
respiration in rats with high doses of atorvastatin and a cholesterol-rich diet
- Lipids Health Dis. 2014 Jan 25;13(1):22 - "The aim of
this study was to evaluate the actions of coenzyme Q10 (CoQ10) on rats with a
cholesterol-rich diet (HD) and high doses of atorvastatin (ATV ... Two
experiments were done, the first one without coenzyme Q10 supplementation. On
the second experiment all groups received coenzyme Q10 0.57 mg/day as
supplement. After a 6-week treatment animals were sacrificed, blood and liver
were analyzed and liver mitochondria were isolated ... the combined
administration of ATV and CoQ10 improved biochemical parameters, liver function
and mitochondrial respiration in hypercholesterolemic rats" - See
ubiquinol products at Amazon.com.
CoQ10 and L-carnitine
for Statin Myalgia? - Medscape, 1/4/13 - "In
summary, it has been proposed that CoQ10 can help to treat statin myalgia. While
this is not conclusive, there are two randomized controlled trials showing
significant improvements in the severity of muscle pain with the use of CoQ10 in
patients treated with statins. Thus, it is not unreasonable to supplement a
patient who is experiencing muscle pains on a statin with CoQ10. While there are
no clinical trials showing improvements in muscle pain with the use of
l-carnitine, patients who experience statin myalgia frequently have carnitine
abnormalities. It is too soon to recommend l-carnitine for statin myalgia, but
future trials should test this supplement to see if it has any place for this
adverse effect. Other common alternatives for treating statin myalgias are
supplementation with vitamin D or vitamin B12, especially in the setting of
suboptimal serum levels"
ubiquinol products at Amazon.com, GPLC at Amazon.com
acetyl l-carnitine products at Amazon.com.
Cholesterol medicine affects energy production in muscles - Science Daily,
1/3/13 - "A well-known side effect of statin therapy is
muscle pain. Up to 75 per cent of the physically active patients undergoing
treatment for high cholesterol experience pain. This may keep people away from
either taking their medicine or from taking exercise -- both of which are bad
choices ... Scientists also showed that the patients examined who were being
treated with statins had low levels of the key protein Q10. Q10 depletion and
ensuing lower energy production in the muscles could be the biological cause of
the muscle pain that is a problem for many patients" - See
ubiquinol products at Amazon.com.
n-3 fatty acids on major cardiovascular events in statin users and non-users
with a history of myocardial infarction - Eur Heart J. 2012 Feb 1 -
"In statin users, an additional amount of n-3 fatty
acids did not reduce cardiovascular events [HR(adj) 1.02; 95% confidence
interval (CI): 0.80, 1.31; P = 0.88]. In statin non-users, however, only 9% of
those who received EPA-DHA plus ALA experienced an event compared with 18% in
the placebo group ... In patients with a history of MI who are not treated with
statins, low-dose supplementation with n-3 fatty acids may reduce major
cardiovascular events. This study suggests that statin treatment modifies the
effects of n-3 fatty acids on the incidence of major cardiovascular events"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
bacteria may affect whether a statin drug lowers cholesterol - Science
Daily, 10/13/11 - "Among the group who had a strong
response to the drug, three bile acids appeared to play a role. The bile acids
are produced by certain gut bacteria, which are increasingly understood as
factories for chemicals that can contribute to a state of health. Among the
people who responded poorly to the statin, five different bile acids were
commonly evident ... new strategies could be developed to manipulate the gut
microbiome using probiotics to spur different gut bacteria, which could then
give the drugs a boost" - See
probiotics at Amazon.com.
reduce deaths from infection and respiratory illness, data eight years on from
trial suggests - Science Daily, 8/28/11 - "In the
lipid-lowering arm of the trial, over 10,000 patients in the UK, Ireland and
Scandinavia with high blood pressure were randomly allocated either atorvastatin
or placebo between 1998 and 2000. In 2003, the trial was stopped early because
the statin proved to be highly beneficial in preventing heart attacks and
strokes. Since then, most participants from both groups have been taking statins
... The new analysis looked at the number and cause of deaths among the 4,605
participants in the ASCOT trial who are based in the UK. After 11 years'
follow-up, overall mortality is 14 per cent lower in the group originally
assigned atorvastatin, due largely to fewer deaths from infection and
effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of
intervention trials - Maturitas. 2010 Dec 14 -
"Lycopene, a carotenoid found in tomatoes ... Meta-analysis of the effect of
lycopene on systolic blood pressure of all trials suggested a significant blood
pressure reducing effect (mean systolic blood pressure change+/-SE:
-5.60+/-5.26mm Hg, p=0.04) ... Our meta-analysis suggests that lycopene taken in
doses ≥25mg daily is effective in reducing LDL cholesterol by about 10% which is
comparable to the effect of low doses of statins in patient with slightly
elevated cholesterol levels" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
Red Yeast Rice Comparable to Pravastatin for Statin-Intolerant Patients
- Medscape, 1/21/10 - "After 12 weeks of treatment,
red yeast rice reduced LDL-cholesterol levels 30% from baseline, from 181
mg/dL to 126 mg/dL, while pravastatin reduced LDL-cholesterol levels 27%, a
nonstatistical difference between treatments. Similarly, there were no
significant differences observed in changes in total cholesterol,
triglycerides, or HDL-cholesterol levels ... Regarding the primary end
point, the incidence of treatment discontinuation because of myalgia, both
red yeast rice and pravastatin were equivalent. In the red-yeast-rice arm,
one patient of 21 (5%) withdrew because of muscle pain, while two patients
of 22 (9%) withdrew in the pravastatin arm. Also, there were no reported
differences in the mean pain severity scores with the two treatments"
red yeast rice at Amazon.com.
B niacin offers no extra benefit to statin therapy in seniors already diagnosed
with coronary artery disease, study suggests - Science Daily, 11/18/09 -
"This does not mean that niacin therapy may not have
other cardiovascular benefits, but any such benefits are independent of reducing
the amount of plaque buildup and patients should be aware of that ... Lima
cautions that an ongoing national study of the long-term vascular benefits of
dual therapy and whether extended-release niacin,
also known as nicotinic acid, lowers death rates from heart disease should
provide more definitive data" - Note: The article implies that
prescription Niaspan works better than immediate release niacin. See
which implies the opposite. The prescription might have less flush but I
couldn't tell the difference. Like I've said in the past, the flush gets
less the longer you use it and is practically non-existent after you taken it
for several months if you take it with food. Also, the slow release may
produce liver damages. See:
Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape,
5/29/09 - "Study subjects were randomized to receive
either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute
improvement in FMD of 1% with CoQ10 supplementation may potentially
translate to a 10-25% reduction in residual cardiovascular risk in these
patients" - See
ubiquinol products at Amazon.com.
Taking Statins? Five Ways
to Boost Your Energy - ABC News, 4/14/09 - "It's
a cruel irony that if statins make patients more lethargic, it could impair
their ability to exercise or make dietary changes that would help them
address their high cholesterol ... some studies have found that patients'
energy levels increased while using CoQ10 and statins together ... Try
pomegranate juice or a small chunk of dark chocolate, both of which have
beneficial antioxidants ... Skimping on sleep has been found to increase
calcium deposit build-up in your arteries" - See
ubiquinol products at Amazon.com.
Statins' Adverse Effects Documented - Science Daily, 1/29/09 -
"Coenzyme Q10 ("Q10") is a compound central to the
process of making energy within mitochondria and quenching free radicals.
However, statins lower Q10 levels because they work by blocking the pathway
involved in cholesterol production – the same pathway by which Q10 is
produced. Statins also reduce the blood cholesterol that transports Q10 and
other fat-soluble antioxidants ... "The loss of Q10 leads to loss of cell
energy and increased free radicals which, in turn, can further damage
mitochondrial DNA," said Golomb, who explained that loss of Q10 may lead to
a greater likelihood of symptoms arising from statins in patients with
existing mitochondrial damage – since these people especially rely on ample
Q10 to help bypass this damage" - My favorite is
QH-Absorb by Jarrow.
Fish Oil, Red Yeast Rice Cut Cholesterol - WebMD, 7/23/08 -
"We followed them for a three-month period ... The
LDL declined 42% in the supplement group and 39% in the Zocor group ... The
supplement group also lost an average of 10 pounds in 12 weeks, but there
was no significant weight loss in the medication group. Triglyceride levels,
while on average normal in both groups at the start, decreased by 29% in the
supplement group but just 9.3% in the medication group -- a significant
difference" - See
red yeast rice at Amazon.com
Mega Twin EPA at Amazon.com.
Lowering Blood Cholesterol With Fish Oil And Red Yeast Rice Instead Of
Statins - Science Daily, 7/8/08 - "The
alternative treatment group participants received daily fish oil and red
yeast rice supplements ... The statin group participants received 40
milligrams (mg) of Zocor (simvastatin) daily ... The researchers noted that
there was a reduction in LDL cholesterol levels in both groups. The
alternative treatment group experienced a 42.4 percent reduction, and the
statin group experienced a 39.6 percent reduction. Members of the
alternative therapy group also had a substantial reduction in triglycerides,
another form of fat found in the blood, and lost more weight" - See
red yeast rice at Amazon.com
Mega Twin EPA at Amazon.com.
Lycopene as effective as statins for artery health: rabbit study - Nutra
USA, 7/3/08 - "The results of our experiment in the
high-fat diet rabbit model showed that lycopene and fluvastatin lowered
serum levels of total cholesterol and LDL-cholesterol, improved lipid
metabolism, and reduced the amount of triacylglycerols ... Lycopene
intervention reduced the increase in ox-LDL levels in rabbits on the
high-fat diet, whereas fluvastatin did not show such an effect. The cause of
this difference is at present not known, although the result speaks in
favour of lycopene ... These findings provide a theoretical rationale for
the use of lycopene as a preventive in atherosclerosis" - [Abstract]
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
Comparison of lycopene and fluvastatin effects on atherosclerosis induced by
a high-fat diet in rabbits - Nutrition. 2008 Jun 26 -
"Compared with the control, levels of total
cholesterol, total triacylglycerol, low-density lipoprotein cholesterol,
malonaldehyde, oxidized low-density lipoprotein, and interleukin-1 were
increased and total antioxidant capacity and nitric oxide were decreased in
the animals with a high-fat diet (P < 0.05). Intragastric administration of
lycopene counteracted the change in these parameters (P < 0.05). In this
case, the data showed that lycopene in the used dose was better than the
fluvastatin intervention. Morphologic analysis revealed that lycopene and
fluvastatin markedly reduced the formation of atherosclerotic plaques in the
aorta compared with the situation in rabbits on a high-fat diet alone ...
Lycopene, like fluvastatin, significantly attenuated atherogenesis in
rabbits fed a high-fat diet" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and
liver and muscle enzyme levels in hypercholesterolemic patients treated with
atorvastatin: A randomized double-blind study - Atherosclerosis. 2007
Aug 4 - "All patients showed definite reductions of
plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented
with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion
atorvastatin definitely decreased plasma CoQ10 levels and supplementation
with CoQ10 increased their levels"
Effect of coenzyme q10 on myopathic symptoms in patients treated with
statins - Am J Cardiol. 2007 May 15;99(10):1409-12 -
"coenzyme Q10 supplementation may decrease muscle
pain associated with statin treatment. Thus, coenzyme Q10 supplementation
may offer an alternative to stopping treatment with these vital drugs"
ubiquinol at Amazon.com.
Combining Agents Leads to Safe Treatment of Lipid Abnormalities -
Physician's Weekly, 5/7/07 -
"Combining the use of statins and niacin should be
encouraged because it appears to safely treat multiple lipid abnormalities
in appropriate high-risk patients"
Niacin Extended-Release Tablets Combined With Low/Moderate Dosed Statin
Achieves Better Total Lipid Control Versus Higher Dose Statin Monotherapy or
Simvastatin and Ezetimibe - Doctor's Guide, 6/22/06 -
"patients given Niaspan in combination with a low to
moderate dose of Lipitor or Crestor achieved equivalent reduction in LDL-C
(51-58%), 1.2 to 1.9-fold greater decreases in triglycerides and 2.5 to 3.5
fold greater increases in HDL-C, than patients who received high-dose
Crestor or Zocor/Zetia" - See
niacin at Amazon.com. My favorite is
Twinlab niacin 1000mg at Amazon.com.
Coenzyme Q10 Lessens Muscle-Related Side Effects in Patients on Statins
- Doctor's Guide, 3/7/05 - "Patients with
significant myopathy who are taking statin therapy have a significant
decrease in myopathic pain after 30 days of supplementation with coenzyme
Q10" - See
ubiquinol at Amazon.com.
- Diet Can Lower
Bad Cholesterol Like Statin Drug - WebMD, 2/8/05 -
"Load up on fiber and vegetables: They lower cholesterol almost as much as
cholesterol-lowering statin drugs ... Here's your shopping list:
Cholesterol-lowering margarines containing plant fats such as "Benecol" or
"Take Control", soy proteins and soluble fibers like oats, barley, psyllium,
plus all kinds of vegetables, including eggplant and okra"
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at
Risk for Cardiovascular Disease and Stroke - Arch Neurol.
2004;61:889-892 - "Even brief exposure to
atorvastatin causes a marked decrease in blood CoQ10
concentration. Widespread inhibition of CoQ10 synthesis could explain the
most commonly reported adverse effects of statins, especially exercise
intolerance, myalgia, and myoglobinuria" - See
ubiquinol at Amazon.com.
- Are Statins the New Wonder
Drugs? - Dr. Weil, 6/21/04 -
"For moderately elevated cholesterol, I recommend
red rice yeast, a natural source of statins
with fewer side effects" - See
red yeast rice at Amazon.com.
Policosonal: Nature's Cholesterol Balancer - Vitamin Research News, 2/04
- "Statin drugs are also known to cause male
impotence" - See
policosanol at Amazon.com.
Diet as Good as Drugs - WebMD, 7/22/03 - "a
vegetarian diet combining four types of cholesterol-lowering foods works as
well as cholesterol-lowering drugs known as statins ... It had four basic
components: plant sterols in the form of a cholesterol-lowering margarine;
soy proteins; sticky or soluble fibers such as fruits, vegetables, oats, and
legumes; and almonds"
- Policosanol more
Effective than Lovastatin for Intermittent Claudication
- New Hope Natural Media, 5/29/03 -
policosanol had a 34% increase in pain-free walking distance, while no
change was observed in those taking lovastatin. Quality of life was also
reported as being significantly better in the policosanol group compared
with the lovastatin group. Both treatment groups had significant reductions
in total cholesterol and LDL cholesterol. However, participants taking
policosanol had a significant 32% increase in
HDL cholesterol and a 6% decrease in fibrinogen, while these parameters
remained unchanged in those receiving lovastatin" - See
policosanol at Amazon.com. Claudication
gets my attention because my father has it and if there is a hereditary
factor, I want to prevent it. - Ben
Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For
Hyperlipidemia - Doctor's Guide, 12/24/02 -
"One group received 3.5 grams of
twice a day and the second group received 20 milligrams of simvastatin each
day ... total
cholesterol decreased by 15.8 percent and low-density lipoprotein (LDL)
cholesterol decreased by 22.97 percent among patients taking ispaghula husk
... Triglycerides decreased by 20.89
percent and high-density lipoprotein (HDL)
cholesterol increased by 10.69 percent in these patients ... Among patients
taking simvastatin, total cholesterol decreased by 24.15 percent, LDL
cholesterol decreased by 36.08 percent, triglycerides decreased by 20.47
percent and HDL cholesterol increased by 11.4 percent" - I've got
that. See psyllium husk at Amazon.com.
- Chinese Cholesterol
Control? - Dr. Weil, 10/1/02 -
"And it contains seven different statins, not just
lovastatin. In my experience, the natural mixture of compounds is less toxic
(to the liver and muscles) than isolated lovastatin ... Other brands of
red rice yeast extract are still available in the U.S., although they
haven’t been clinically proven as was Cholestin, and may not be as
Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese,
Insulin-Resistant Men - Doctor's Guide, 8/7/02 -
"fish oils significantly decreased plasma levels of
triglycerides and very low density lipoprotein-apoB, decreased the very
low density lipoprotein-apoB secretion rate ... combined treatment with
atorvastatin and fish oils decreased very
low density lipoprotein-apoB secretion and increased the fractional
catabolic rate of apoB in each lipoprotein fraction , as well as the percent
conversion of very low density lipoprotein to low density lipoprotein"
- See TwinLab Mega Twin EPA at Amazon.com
Dr. Julian M. Whitaker Petitions FDA to Include CoQ10 Use Recommendation in
All Statin Drug Labeling - Life Extension Magazine, 8/02 -
"On May 23, 2002, Dr. Julian M. Whitaker filed two
citizens petitions with the Food and Drug Administration. The petitions call
on the Commissioner of Food and Drugs to change the labeling of all HMG CoA
reductase inhibitor drugs (the so-called statin drugs), and to issue a
Medication Guide, warning consumers of the need to take
coenzyme Q10 (CoQ10) whenever they take a statin drug"
- Vitamins Help
After Heart Transplant - WebMD, 3/28/02 - "The
plaque-fighting benefits of the antioxidant
were even greater than those found using statin medications, which have
already been shown to slow hardening of the arteries after transplants.
Previous research has shown that antioxidants, such as
vitamin C and E, can promote heart health
by reducing blood clots and keeping the blood vessels flexible"
and risk of primary liver cancer in the clinical practice research datalink
- J Natl Cancer Inst. 2015 Feb 26;107(4) - "Statin use
was associated with a statistically significantly reduced risk of liver cancer (ORadj
= 0.55, 95% CI = 0.45 to 0.69), especially among current users (ORadj = 0.53,
95% CI = 0.42 to 0.66). The reduced risk was statistically significant in the
presence (ORadj = 0.32, 95% CI = 0.17 to 0.57) and absence of liver disease (ORadj
= 0.65, 95% CI = 0.52 to 0.81) and in the presence (ORadj = 0.30, 95% CI = 0.21
to 0.42) and absence of diabetes (ORadj = 0.66, 95% CI = 0.51 to 0.85)"
Can Statins Help Improve Prostate Cancer Survival? - WebMD, 3/10/15 -
"Taking a statin alongside androgen deprivation therapy
slowed the progress of prostate cancer by about 10 months ... Patients on a
statin have a significantly longer time to progression"
reverse learning disabilities caused by genetic disorder - Science Daily,
11/10/14 - "Here's how it works: statin drugs lower
cholesterol by blocking the synthesis of certain fat molecules that Ras requires
to function. The resulting drop in Ras activity allows brain cells to
communicate properly, allowing normal learning to take place ... We were amazed
to see that statin treatment restored the adult animals' cognitive functions to
normal ... UCLA's approach could help the estimated 35 million Americans who
struggle with learning disabilities"
Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A
Randomized Clinical Study - Med Sci Monit. 2014 Nov 6;20:2183-2188 -
"The present results show that coenzyme Q10
supplementation (50 mg twice daily) effectively reduced statin-related
mild-to-moderate muscular symptoms, causing lower interference of statin-related
muscular symptoms with daily activities" - See
ubiquinol products at Amazon.com.
Statins May Help Prevent Diabetes-Related Nerve Damage, Study Finds - WebMD,
9/9/14 - "The researchers compared the outcomes of more
than 15,500 patients who used statins to more than 47,000 patients who were not
taking the drugs ... After a median follow-up of 2.7 years, the study showed
that people who used statins were 34 percent less likely to be diagnosed with
diabetes-related nerve damage and 40 percent less likely to develop
diabetes-related damage to the retina. These patients also had a 12 percent
lower risk of gangrene than those who did not take statins"
After Colorectal Cancer Diagnosis and Survival: A Population-Based Cohort Study
- J Clin Oncol. 2014 Aug 4 - "Overall, statin use after
a diagnosis of colorectal cancer was associated with reduced colorectal
cancer-specific mortality (fully adjusted HR, 0.71; 95% CI, 0.61 to 0.84). A
dose-response association was apparent; for example, a more marked reduction was
apparent in colorectal cancer patients using statins for more than 1 year
(adjusted HR, 0.64; 95% CI, 0.53 to 0.79). A reduction in all-cause mortality
was also apparent in statin users after colorectal cancer diagnosis (fully
adjusted HR, 0.75; 95% CI, 0.66 to 0.84)"
HDL-C in Response to Statin Treatment is Involved in the Regression of Carotid
Atherosclerosis - J Atheroscler Thromb. 2014 Jun 13 -
"The administration of statins for 3 years to subjects
with type 2 diabetes resulted in a significant regression of the carotid IMT. An
elevation of the plasma HDL-C with statin treatment was closely related to a
regression of atherosclerosis"
Statins and Prostate
Cancer: Novel, Encouraging Study - Medscape, 5/13/14 -"radical
prostatectomy (RP) ... not
all statins are equal; the protective effect was limited to the lipophilic
statins (e.g., atorvastatin, lovastatin, and simvastatin) ... researchers
retrospectively compared biochemical recurrence in men who started statins after
surgery with recurrence in men who were never users ... In all, only 16% post-RP
statin users (65/400) had biochemical recurrence, compared with 45% of nonusers
As Statins Boost Erectile
Function, Adherence May Rise Too - Medscape, 3/29/14 -
"In men who took statins, erectile-function scores
increased by 3.4 points, from 14.0 to 17.4 points—a 24.3% increase. The increase
in erectile-function score was about one-third to one-half of that reported with
phosphodiesterase inhibitors, such as sildenafil (Viagra, Pfizer), tadalafil (Cialis,
Lilly), or vardenafil (Levitra, Bayer/GlaxoSmithKline), and larger than the
effect of lifestyle modification or testosterone" - [Science
small number of symptomatic side effects reported in those taking statins are
actually attributable to statins, study finds - Science Daily, 3/13/14 -
"The study, a meta-analysis involving more than 80,000
patients and reported today in the European Journal of Preventive Cardiology,
was performed without funding from any agency in the public, commercial or
not-for-profit sectors ... Overall, the study found serious adverse effects in
14.6% of patients receiving statins and 14.9% given placebo in the primary
prevention trials, and in 9.9% of those on statins and 11.2% on placebo in the
secondary prevention trials. Similarly, comparable numbers of patients withdrew
from the trials because of symptomatic adverse events (around 12-15%) ... Most
people in the general population, if you repeatedly ask them a detailed
questionnaire, will not feel perfectly well in every way on every day. Why
should they suddenly feel well when taking a tablet after being warned of
possible adverse effects?"
use reduces delirium in critically ill patients - Science Daily, 1/17/14
- "administration of statins the previous evening was
associated with a significantly lower risk of delirium and a concomitant
reduction in serum C-reactive protein (CRP), a marker of systemic inflammation,
the following day"
Therapy, Fitness, and Mortality Risk in Middle-Aged Hypertensive Male Veterans
- Am J Hypertens. 2014 Jan 16 - "Peak exercise capacity
was assessed in 10,202 hypertensive male subjects (mean age = 60.4±10.6 years)
in 2 Veterans Affairs Medical Centers. We established 4 fitness categories based
on peak metabolic equivalents (METs) achieved and 8 categories based on fitness
status and statin therapy ... follow-up period (median = 10.2 years) ...
Mortality risk was 34% lower (hazard ratio (HR) = 0.66; 95% confidence interval
(CI) = 0.59-0.74; P < 0.001) among individuals treated with statins compared
with those not on statins. The fitness-related mortality risk association was
inverse and graded regardless of statin therapy status. Risk reduction
associated with exercise capacity of 5.1-8.4 METs was similar to that observed
with statin therapy. However, those achieving ≥8.5 METs had 52% lower risk (HR =
0.48; 95% CI = 0.37-0.63) when compared with the least-fit subjects (≤5 METs) on
Aspirin for Chemoprevention in Barrett's Esophagus: Results of a
Cost-Effectiveness Analysis - "Cancer Prev Res (Phila). 2013 Dec 31 -
"aspirin chemoprevention was both more effective and
cost less than endoscopic surveillance alone. Combination therapy using both
aspirin and statin is expensive but could be cost-effective in patients at
higher risk of progression to EAC"
statin treatment on coronary plaque progression - A serial coronary CT
angiography study - Atherosclerosis. 2013 Dec;231(2):198-204 -
"The study included 100 consecutive patients who
underwent serial Coronary CTA (mean follow up: 406 ± 92 days) for evaluation of
CAD without known prior heart disease or revascularization. We performed
volumetric assessment of low attenuation plaque (LAP < 30 Hounsfield units),
non-calcified (NCP) and calcified plaque volumes at baseline and follow up scans
for vessels >2 mm in diameter ... Statin therapy resulted in significantly lower
progression of LAP and NCP plaques compared to non-statin users"
the risks of stroke recurrence and death after ischemic stroke: The Fukuoka
Stroke Registry - Atherosclerosis. 2013 Dec;231(2):211-5 -
"CVEs: stroke recurrence or transient ischemic attack)
and all-cause mortality in a cohort of Japanese patients with first-ever
ischemic stroke ... The 2822 eligible patients registered in the Fukuoka Stroke
Registry with first-ever acute ischemic stroke from June 2007 to February 2011
were classified into statin users (n = 993) and non-users (n = 1829) at
discharge, and followed up until March 2012 ... The cumulative risks of CVE and
death after 4 years were significantly lower in statin users than in non-users
(13.8% versus 19.5%, P = 0.005 for CVE; 11.8% versus 21.7%, P < 0.001 for
death). After adjusting for multiple confounding factors, statin treatment
significantly reduced the risks of CVE (HR, 0.70; 95% CI, 0.53 to 0.92; P =
0.011) and all-cause mortality (HR, 0.67; 95% CI, 0.50 to 0.89; P = 0.006)"
Statins and the Risk of Death in Patients With Prostate Cancer - J Clin
Oncol. 2013 Nov 4 - "Postdiagnostic use of statins was
associated with a decreased risk of prostate cancer mortality (HR, 0.76; 95% CI,
0.66 to 0.88) and all-cause mortality (HR, 0.86; 95% CI, 0.78 to 0.95). These
decreased risks of prostate cancer mortality and all-cause mortality were more
pronounced in patients who also used statins before diagnosis (HR, 0.55; 95% CI,
0.41 to 0.74; and HR, 0.66; 95% CI, 0.53 to 0.81, respectively), with weaker
effects in patients who initiated the treatment only after diagnosis (HR, 0.82;
95% CI, 0.71 to 0.96; and HR, 0.91; 95% CI, 0.82 to 1.01, respectively)"
Lipid-Lowering Drugs Associated With Slower Motor Decline in the Elderly Adults
- J Gerontol A Biol Sci Med Sci. 2013 Oct 4 - "We
investigated the relationship between lipid-lowering drugs (LLDs) use and
decline in walking speed (WS) in older adults ... 4,009 community-dwelling men
and women, aged ≥65 years at baseline, are drawn from the Dijon (France) center
of the Three-City study ... WS decline was 25% slower in LLDs users ... Fast WS
declined less in those on LLDs, suggesting that the effect of LLDs, statins in
particular, extend beyond that on cardiovascular disease in the elderly persons"
Cognition: A Systematic Review and Meta-analysis of Short- and Long-term
Cognitive Effects - Mayo Clin Proc. 2013 Sep 27 - "A
systematic search was performed of MEDLINE, EMBASE, and the Cochrane Central
Register from their inception to April 25, 2013 ... Long-term cognition studies
included 23,443 patients with a mean exposure duration of 3 to 24.9 years. Three
studies found no association between statin use and incident dementia, and 5
found a favorable effect. Pooled results revealed a 29% reduction in incident
dementia in statin-treated patients"
High-Dose Statins Reduce Gum Inflammation in Heart Disease Patients -
Science Daily, 10/2/13 - "Periodontitis and
atherosclerosis are both primarily driven by inflammation. These inflammatory
conditions tend to co-exist within individuals and their biologies may be
intertwined ... patients with heart disease or a high heart disease risk were
assigned to take either an 80 mg statin or a 10 mg statin daily for 12 weeks ...
The 59 patients included in the final analysis showed a significant reduction in
gum inflammation after as few as four weeks of treatment with the high-dose
statin. Interestingly, the improvement in gum inflammation tracked closely with
improvement in atherosclerotic disease"
May Prevent Dementia, Memory Loss With Longer Use, Don't Pose Short-Term
Cognition Problems - Science Daily, 10/1/13 -
"statins do not affect short-term memory or cognition. In contrast, they say
that when the drugs are taken for more than one year, the risk of dementia is
reduced by 29 percent ... We looked at high-quality, randomized controlled
trials and prospective studies that included more than 23,000 men and women with
no prior history of cognitive problems. The participants in those studies were
followed for up to 25 years ... Vascular dementia is caused by blockages in
small blood vessels in the brain that prevent blood flow to certain areas.
Medications such as statins that reduce plaque and inflammation in coronary
arteries may also be having the same effect on blood vessels in the brain"
use of statins reduces the risk of hospitalization for dementia -
Atherosclerosis. 2013 Oct;230(2):171-6 - "A
population-based, nested case-control study was carried out by including the
cohort of 152,729 patients from Lombardy (Italy) aged 40 years or older who were
newly treated with statins between 2003 and 2004. Cases were the 1380 patients
who experienced hospitalization for dementia disease from initial prescription
until 2010 ... Compared with patients who had very short statins coverage (less
than 6 months), those on 7-24, 25-48, and >48 months of coverage respectively
had risk reductions of 15% (OR: 0.85; 95% CI: 0.74 to 0.98), 28% (OR: 0.72; 95%
CI: 0.61 to 0.85), and 25% (OR: 0.75; 95% CI: 0.61 to 0.94). Simvastatin and
atorvastatin were both associated with a reduced risk of dementia, while no
similar evidence was observed for fluvastatin and pravastatin"
Atorvastatin Reduces Periodontal Inflammation: A Novel Pleiotropic Effect of
Statins - J Am Coll Cardiol. 2013 Sep 23 -
"Eighty-three adults with risk factors or with established atherosclerosis, who
were not taking high-dose statins, were randomized to atorvastatin 80 mg vs.
10mg in a multicenter, double-blind trial to evaluate the impact of atorvastatin
on arterial inflammation ... After 12 weeks, there was a significant reduction
in periodontal inflammation in patients randomized to atorvastatin 80 vs. 10 mg
(ΔTBR mean [95 CI], 80mg vs. 10mg group = -0.43 [-0.83, -0.02], p=0.04).
Between-group differences were greater in patients with higher periodontal
inflammation at baseline (-0.74 [-1.29, -0.19], p=0.01) and in patients with
severe bone loss at baseline (-0.61 [-1.16, -0.054], p=0.03). Furthermore, the
changes in periodontal inflammation correlated with changes in carotid
Statins Tied to Cataract Risk - NYTimes.com, 9/25/13 -
"scientists retrospectively examined 13,626 statin users
and 32,623 nonusers, ages 30 to 85, who were part of a military health care
system. The average length of statin use was about two years ... compared with
nonusers, those who took statins had a 9 to 27 percent increased risk for
Cognitive Decline in Older Adults with Normal Cognition or Mild Cognitive
Impairment - J Am Geriatr Soc. 2013 Sep 3 -
"Research volunteers with normal cognition at baseline evaluated an average
4.1 times over 3.4 years (1,244 statin users, 2,363 nonusers) and with mild
cognitive impairment (MCI) at baseline evaluated an average 3.9 times over 2.8
years (763 users, 917 nonusers) ... Cognitive performance was assessed according
to 10 neuropsychological indices and the Clinical Dementia Rating Sum of Boxes
(CDR-SOB) ... Of participants with normal cognition at baseline, statin users
performed significantly better across all visits in attention (Trails A) and had
significantly slower annual worsening in CDR-SOB scores (P = .006) and slower
worsening in Mini-Mental State Examination scores than nonusers (which was not
significant after adjusting for multiple comparisons, P = .05). For participants
with MCI, statin users performed significantly better across all visits on
attention measures (Trail-Making Test Part A), verbal skills (Category Fluency),
and executive functioning (Trail-Making Test Part B, Digit Symbol, and Digits
Backward), but there were no differences in cognitive decline between users and
Statins reduce cardiovascular events in coronary artery disease patients
with very low LDL cholesterol levels - Science Daily, 8/31/13 -
"Major Cardiovascular Events (MACE) ... used the
Ibaraki Cardiovascular Assessment Study (ICAS), a registry of 2,238 patients
from 12 hospitals in the Ibaraki region of Japan ... Based on serum LDL-C
levels at initial presentation participants were classified into three
groups: very low (<70 mg/dl, n=214); low (71-100 mg/dl, n=669); and high
(>101 mg/dl, n= 1,355) ... followed up for a maximum of 3 years ... three
years of statin treatment produced significant reductions in the incidence
of MACE in all three groups"
dose statins prevents dementia, study suggests - Science Daily, 8/31/13
- "the current study examined whether statin use was
associated with new diagnoses of dementia. The researchers used a random
sample of 1 million patients covered by Taiwan's National Health Insurance
... The adjusted hazard ratios (HRs) for dementia were significantly
inversely associated with increased daily or total equivalent statin dosage.
The HRs for the three tertiles of mean equivalent daily dosage (lowest to
highest) were 0.622, 0.697 and 0.419 vs control ... Patients who received
the highest total equivalent doses of statins had a 3-fold decrease in the
risk of developing dementia ... Almost all the statins (except lovastatin)
decreased the risk for new onset dementia when taken at higher daily doses.
A high mean daily dosage of lovastatin was positively associated with the
development of dementia, possibly because lovastatin is a lipophilic statin
while the anti-inflammatory cholesterol lowering effect of lovastatin is not
comparable to that of atorvastatin and simvastatin" - Note: The brand
names are Mevacor (lovastatin), Lipitor (atorvastatin calcium), Zocor
Statins Prevent Cataracts, Study Suggests - Science Daily, 8/31/13 -
"Statins lower the rate of cataract by 20 percent
... The risk of cataract was reduced by 50 percent when treatment was
initiated in younger individuals (in their 40s) and the duration of therapy
was longer (e.g. up to 14 years) ... The meta-analysis included 2,399,200
persons and 25,618 cataracts. The average duration of treatment was 54
months and average age was 61"
Statins may slow human aging by protecting against telomere shortening: A
feature of senescent cells - Science Daily, 8/29/13 -
"statins may reduce the rate at which telomeres
shorten, a key factor in the natural aging process ... worked with two
groups of subjects. The first group was under chronic statin therapy, and
the second group (control), did not use statins. When researchers measured
telomerase activity in both groups, those undergoing statin treatment had
higher telomerase activity in their white blood cells, which was associated
with lower telomeres shortening along with aging as compared to the control
group. This strongly highlights the role of telomerase activation in
preventing the excessive accumulation of short telomeres"
Statin Use May Reduce Parkinson's Risk, Study Says - WebMD, 7/24/13 -
"Analyzing nearly 44,000 patients, scientists found
that those who discontinued taking fat-soluble statins such as simvastatin
(Zocor) or atorvastatin (Lipitor) were about 58 percent more likely to
develop Parkinson's than those who kept taking the drugs ... Fat-soluble
statins are believed to cross the blood-brain barrier, unlike water-soluble
statins such as rosuvastatin (Crestor) and pravastatin (Pravachol). The
drugs may decrease inflammation and even modify dopamine pathways in the
brain, which are linked to Parkinson's ... The new study, which took place
from 2001 to 2008 on statin patients free of Parkinson's disease, also
showed that participants taking water-soluble statins developed Parkinson's
at about twice the rate as those taking fat-soluble statins"
Do Statins Protect
Against Glaucoma? - Medscape, 5/13/13 -
"open-angle glaucoma (OAG) ... used a nationwide healthcare claims database
containing detailed medical records for more than 500,000 patients with
hyperlipidemia to determine whether an association exists between statin use
and the development of OAG ... the risk for OAG decreased 0.3% (adjusted
hazard ratio [HR], 0.997; 95% confidence interval [CI], 0.994-0.999) for
every additional month of statin use. Individuals with hyperlipidemia who
took statins continuously for 2 years had an 8% (adjusted HR, 0.922; 95% CI,
0.870-0.976) lower OAG risk compared with those who received no statin
Cholesterol Drugs Might Boost Kidney Cancer Survival - WebMD, 5/7/13 -
"Over three years, 10 percent of the patients who
took statins died of their cancer, compared with 17 percent of those who did
not take this type of drug ... Last year in a study published in the New
England Journal of Medicine, Danish researchers studied 13 different cancers
and found that in all types, the use of statins was associated with longer
cancer specific survival"
Taking cholesterol-lowering drugs may also reduce the risk of dying from
prostate cancer - Science Daily, 5/2/13 - "After
a mean follow-up of almost eight years, the researchers found that the risk
of death from prostate cancer among statin users was 1 percent as compared
to 5 percent for nonusers"
Statins and Cancer
Mortality: Some Comfort - Medscape, 2/25/13 -
"They found that, overall, no matter what dose of statin patients were
taking, statins reduced cancer mortality by about 15%"
Statins and Colorectal
Cancer - Medscape, 2/18/13 - "In a retrospective
analysis conducted in more than 2500 veterans with a history of colonoscopic
polypectomy for adenomas, Siddiqui et al showed a 49% reduction in the
incidence of recurrent adenomas, and a 29% reduction in the incidence of
advanced adenomas, associated with continuous statin use over 3 to 5 years.
In a subsequent analysis of 231 individuals from the same population,
significantly fewer adenomas, of smaller size, were observed at follow-up
colonoscopy in individuals who had achieved 30% or more reduction in LDL
cholesterol level, compared with those who had not. This suggests that lipid
lowering, rather than statin use per se, may be partly responsible for the
effect of statins on adenoma development and progression. An independent
case-control study of 197 patients, also from a veterans population, found
no association between statin use and adenoma recurrence over a median of
3.4 years. Furthermore, a secondary analysis of data from 3 large
colorectal adenoma chemoprevention trials, with a combined total of 2915
subjects, failed to show any association between statin use and the
recurrence of any adenomas, multiple adenomas, or advanced adenomas. The
prevalence of self-reported statin use was, however, low (8.1%) across the 3
chemoprevention trials, limiting power for the post hoc analysis. Statin
users comprised a much larger proportion (37%) of participants in the
Adenoma Prevention With Celecoxib (APC) trial. However, in a secondary
analysis of APC trial data, Bertagnolli et al found no evidence to
support a chemopreventive effect of statin use over 5 years of follow-up. On
the contrary, statin use of more than 3 years was associated with a 39%
increased risk of adenoma recurrence. Although these data are derived from
an RCT, statin use was self-selected, and the patient population comprised
only high-risk patients with a history of multiple or large adenomas,
limiting the generalizability of the results. Nonetheless, this analysis
represents a large prospective study of statin use and incident adenomas.
Furthermore, assessment of the association between statin use and study end
points was a planned secondary analysis"
and colorectal cancer risk: a longitudinal study - Cancer Causes
Control. 2013 Jan 30 - "After multivariable
adjustment, initiators of statins had a lower incidence rate of CRC as
compared to initiators of glaucoma drugs [hazard ratio (HR) 0.79; 95 % CI
0.69-0.90]. In sex-stratified analyses we observed a protective effect in
men (HR 0.77; 95 % CI 0.67-0.88) but not in women (HR 0.96; 95 % CI
use and reduced cancer-related mortality - N Engl J Med. 2012 Nov 8 -
"Multivariable-adjusted hazard ratios for statin
users, as compared with patients who had never used statins, were 0.85 (95%
confidence interval [CI], 0.83 to 0.87) for death from any cause and 0.85
(95% CI, 0.82 to 0.87) for death from cancer"
Statins may reduce risk of esophageal cancer - Science Daily, 10/22/12 -
"Only 1 in 5 patients with this cancer will still be
alive five years after diagnosis ... The Mayo study combined data from 13
studies that included over 1.1 million patients, of which 9,285 had
esophageal cancer. The analysis found statins lowered cancer risk by nearly
one-third; the longer a patient was on statins, the greater the protective
effect ... When researchers looked specifically at Barrett's esophagus,
patients taking a statin and aspirin reduced their risk of esophageal cancer
by 72 percent"
Use As a Moderator of Metformin Effect on Risk for Prostate Cancer Among
Type 2 Diabetic Patients - Diabetes Care. 2012 Mar 28 -
"Mean follow-up was ~5 years, and 7.5% had a PCa
diagnosis. Statin use modified the effect of metformin on PCa incidence (P <
0.0001). Metformin was associated with a significantly reduced PCa incidence
among patients on statins (HR 0.69 [95% CI 0.50-0.92]; 17 cases/533
metformin users vs. 135 cases/2,404 sulfonylureas users) and an increased
PCa incidence among patients not on statins (HR 2.15 [1.83-2.52]; 22
cases/175 metformin users vs. 186 cases/1,930 sulfonylureas users). The HR
of PCa incidence for those taking metformin and statins versus those taking
neither medication was 0.32"
Low Levels of LDL
Cholesterol Predate Cancer Cases - Medscape, 3/25/12 -
"there is nothing here to suggest that statins would
Statin Risks Outweighed by Statin Benefits - USA Today, 3/1/12 -
"Clinical trials show that all of these
cholesterol-lowering drugs cut the risk of heart disease by 25% to 30% ...
analyses of controlled trials show that those who cross the threshold into
diabetes had exactly the same benefits of the statin ... As for the memory
loss and confusion, Nissen says it is "rare and completely reversible.""
New Warnings on Cholesterol-Lowering Statins - WebMD, 2/28/12 -
"Memory loss, confusion, high blood sugar, and type
2 diabetes are possible side effects of the popular cholesterol-lowering
drugs known as statins ... Brand name and generic versions of statin drugs
must carry these warnings on their labels"
Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's
Health Initiative - Arch Intern Med. 2012 Jan 9 -
"The WHI recruited 161 808 postmenopausal women aged
50 to 79 years at 40 clinical centers across the United States from 1993 to
1998 with ongoing follow-up ... Statin use at baseline was associated with
an increased risk of DM (hazard ratio [HR], 1.71; 95% CI, 1.61-1.83). This
association remained after adjusting for other potential confounders
(multivariate-adjusted HR, 1.48; 95% CI, 1.38-1.59) and was observed for all
types of statin medications"
Statins linked to higher diabetes risk - USATODAY.com, 1/9/12 -
"Study authors advise patients not to stop taking
their medications without talking to a doctor, because statins' proven power
to prevent heart attacks and strokes outweighs any potential increase in
type 2 diabetes risk. But the results - a nearly 50% increase in diabetes
among longtime statin users - should throw cold water on the idea of
prescribing these drugs to healthy people, which some have recommended as a
way to prevent disease ... In the study, 6.4% of women who didn't use
statins developed diabetes during the eight to nine years of follow-up ...
That rate rose to 9.9% among statin users"
Prescriptions and Breast Cancer Recurrence Risk - Medscape, 12/22/11 -
"It is possible that some past incidence studies did
not observe an association because a high proportion of statin users took
hydrophilic drugs. For instance, Cauley et al. observed a lower risk of
breast cancer among lipophilic statin users, 82% of whom took either
simvastatin or lovastatin (HR = 0.82, 95% CI = 0.70 to 0.97); and Boudreau
et al. observed an inverse association with overall statin use, when
approximately 48% of the study participants were simvastatin or lovastatin
users (odds ratio = 0.7, 95% CI = 0.4 to 1.0). However, Woditschka et
al. observed no association between statin use and breast cancer
incidence in which most users were exposed to the lipophilic drugs
simvastatin and lovastatin (odds ratio = 1.02, 95% CI = 0.97 to 1.08);
and Friis et al. studied statin use and breast cancer incidence in a
Danish population that overlaps with the population analyzed in our study
(so simvastatin is expected to have accounted for a large proportion of the
overall statin exposure) and also observed no association; (relative risk =
1.02, 95% CI = 0.76 to 1.36). Although the apparent discordance between
the statin associations with breast cancer incidence and recurrence may be
explained by inadequate exposure characterization with respect to
solubility, it is also important to realize that factors which prevent
recurrence are not necessarily expected to also prevent incidence"
Study: Statins reduce flu death risk by half - USA Today, 12/14/11 -
"Patients on statins were 41 percent less likely to
die, the study found, even after adjusting for age, the presence of heart,
lung and/or kidney disease, whether or not they had had a flu shot, or
whether or not they had received antiviral medications such as Tamiflu ...
There's no question that these observations are striking in terms of death
from influenza but they can't say why"
of early statin therapy in patients with acute myocardial infarction who
have extremely low low-density lipoprotein cholesterol - J Am Coll
Cardiol. 2011 Oct 11;58(16):1664-71 - "Intensive
lipid-lowering therapy with a target LDL-C value <70 mg/dl is recommended in
patients with very high cardiovascular risk. However, whether to use statin
therapy in patients with baseline LDL-C levels below 70 mg/dl is
controversial ... Statin therapy significantly reduced the risk of the
composite primary endpoint (adjusted hazard ratio [HR]: 0.56; 95% confidence
interval [CI]: 0.34 to 0.89; p = 0.015). Statin therapy reduced the risk of
cardiac death (HR: 0.47; 95% CI: 0.23 to 0.93; p = 0.031) and coronary
revascularization (HR: 0.45, 95% CI: 0.24 to 0.85; p = 0.013). However,
there were no differences in the risk of the composite of all-cause death,
recurrent MI, and repeated percutaneous coronary intervention rate"
More Evidence for Lowering LDL to Below 70 - Medscape, 10/4/11 -
"They compared outcomes among 1054 patients with LDL
levels below 70 mg/dL at the time of their MI as to whether they were
discharged on a statin or not ... Results showed that the rate of major
adverse cardiac events at one year was significantly lower in those patients
who were taking a statin, with the benefit mainly driven by the reduction of
cardiac death and coronary revascularization ... Dr Roger Blumenthal (Johns
Hopkins University, Baltimore, MD) suggested the study supported the
pleiotropic effects of statins and the idea that the ideal LDL-C is probably
closer to 50 than to 70 mg/dL ... levels of LDL below 70 are on a par with
those of nonhuman primates who don't develop atherosclerosis, adding that,
like these primates, humans were designed to be vegetarians ... Chimpanzees
don't eat meat; they eat very little fat. They have LDL levels in the range
of 40 to 70, and they don't get atherosclerosis. Maybe we wouldn't get
atherosclerosis either if we had levels this low"
mortality according to lipid-lowering drugs and lipoproteins in a general
population - Curr Med Res Opin. 2011 Sep 7 -
"The beneficial effect of lipid-lowering drugs (LLD) on cardiovascular risk
is established, but long term safety data remain scarce. Our aim was to
assess 10-year risk of cancer mortality according to blood lipoprotein
levels and LLD exposure, in a general population ... There were 3262
participants and 177 deaths were recorded over the 10-year period (78 due to
a cancer). The sample comprised 64% of normolipidaemic, 25% of untreated
dyslipidaemic and 11% of dyslipidaemic subjects treated with LLD (4%
statins, 6% fibrates and 1% other hypolipidaemic drugs). After adjustment
for centre, age, gender, smoking, gamma-glutamyl transpeptidase and mean
corpuscular volume, the hazard ratios (HR) for cancer mortality in subjects
with non-HDL cholesterol <3.5 mmol/L (135 mg/dL) and in those with HDL
cholesterol <0.90 mmol/L (35 mg/dL) were 2.74 (95% confidence interval:
1.66-4.52, p < 0.001) and 2.83 (1.62-4.96, p < 0.001), respectively. The
adjusted HR for cancer mortality was 0.31 (0.11-0.86, p = 0.025) in people
on LLD compared to untreated subjects. Conclusions: In the present study, we
confirm the significant association between low cholesterol and cancer
mortality without finding any harmful signal regarding cancer risk
associated with the use of LLD"
Intake of Cholesterol Is Positively and Use of Cholesterol-Lowering
Medication Is Negatively Associated with Prevalent Age-Related Hearing Loss
- J Nutr. 2011 May 25 - "After multivariable
adjustment, the likelihood of prevalent hearing loss increased from the
lowest (reference) to the highest quartile of dietary cholesterol intake
(P-trend = 0.04). Among persons self-reporting statin use (n = 274), a 48%
reduced odds of prevalent hearing loss was observed after multivariable
adjustment [OR = 0.52 (95% CI = 0.29-0.93)]. Participants in the second and
3rd quartiles of dietary monounsaturated fat intake compared with those in
the first quartile (reference) had a significantly reduced risk of hearing
loss progression 5 y later [multivariable-adjusted OR = 0.39 (95% CI =
0.21-0.71)] and [OR = 0.51 (95% CI = 0.29-0.91)], respectively. Our results
suggest that a diet high in cholesterol could have adverse influences on
hearing, whereas treatment with statins and consumption of monounsaturated
fats may have a beneficial influence"
and Prostate Cancer Diagnosis and Grade in a Veterans Population - J
Natl Cancer Inst. 2011 Apr 15 - "Compared with men
taking an antihypertensive medication, statin users were 31% less likely (HR
= 0.69, 95% CI = 0.52 to 0.90) to be diagnosed with prostate cancer.
Furthermore, statin users were 14% less likely (HR = 0.86, 95% CI = 0.62 to
1.20) to be diagnosed with low-grade prostate cancer and 60% less likely (HR
= 0.40, 95% CI = 0.24 to 0.65) to be diagnosed with high-grade prostate
cancer compared with antihypertensive medication users. Increased levels of
total cholesterol were also associated with both total (HR = 1.02, 95% CI =
1.00 to 1.05) and high-grade (HR = 1.06, 95% CI = 1.02 to 1.10) prostate
cancer incidence but not with low-grade prostate cancer incidence (HR =
1.01, 95% CI = 0.98 to 1.04)"
Statins make radiation more effective at curing prostate cancer, study
suggests - Science Daily, 3/23/11 - "the men
taking statins were less like to relapse than other patients. At five years,
11 percent of men taking statins saw their cancer return compared to 17
percent of patients not taking the medication. At eight years, 17 percent of
men on statins had a relapse compared to 26 percent not taking the drug"
Statins may prevent diabetic-related blindness, study suggests - Science
Daily, 2/17/11 - "oral treatment with the drug
atorvastatin blocked the formation of free radicals in the retina, which
restored proper levels of nerve growth factor and preserved neurons in the
retina. "It removed the break on the pro-form nerve growth factor to develop
into its mature form," she said. The drug was orally administered to rats in
doses proportional to levels given to human patients with cardiovascular
problems ... In a related study, also in the March edition of the journal
Diabetologia, El-Remessy and her colleagues found that epicathecin, a
component of green tea, also prevented the adverse actions of proNGF in the
retina. It does not affect the maturation of proNGF into NGF, explained
El-Remessy, but regulated a receptor downstream that proNGF uses to send a
signal to kill the neuron. Epicathechin prevents the death by inhibiting
that receptor. "We are still getting the same result, that we are preventing
neuronal death and restoring neuronal function, but just in a different
way,"" - See
green tea extract at Amazon.com.
Statins Lower Cardiovascular Risk Regardless of Baseline LDL : Abstract and
Introduction - Medscape, 1/21/11 - "In the
placebo-controlled trials, statin recipients had a 41-mg/dL greater decline
in LDL-C and a significant 22% reduction in first major vascular events
(2.8% vs. 3.6% annually). In the high-dose versus low-dose trials, high-dose
patients had a 20-mg/dL greater decline in LDL-C and a significant 15%
reduction in first major vascular events (4.5% vs. 5.3% annually). Relative
risk reductions of about 20% per 40-mg/dL decline in LDL-C were seen in both
placebo-controlled and high- versus low-dose trials for all prespecified
patient subgroups, and at all baseline LDL-C levels (including <80 mg/dL)"
Statin risks may outweigh benefits for patients with a history of brain
hemorrhage - Science Daily, 1/10/11
Statin use associated with statistically significant reduction in colorectal
cancer - Science Daily, 10/18/10 - "The relative
risk was 0.88 (95% CI 0.84-0.93; n=22) and represents a 12% reduction in the
odds of colorectal cancer among statin users ... the most common category of
statins, lipophilic (which includes atorvastatin or Lipitor®), showed the
greatest effect ... long-term use of statins is associated with reduced risk
of several cancers, including breast, prostate, lung, pancreas and liver"
Regular statin use is associated with a reduced risk of developing
rheumatoid arthritis - Science Daily, 9/7/10 -
"After adjusting for other possible confounders, patients who persistently
took statins had a lower risk (risk ratio of 0.58) of developing rheumatoid
arthritis compared with patients who did not persistently take statins.
There was only a small short term decrease in risk ratio in patients taking
statins and the development of osteoarthritis. (hazard ratio of 0.85)"
Statins associated with lower cancer recurrence following prostatectomy
- Science Daily, 6/28/10 - "the data showed that
overall, statin use reduced the risk of biochemical recurrence by 30 percent
... Among men taking statins equivalent to 20 mg of simvastatin a day, the
risk of recurrence was reduced 43 percent and among the men taking the
equivalent of more than 20 mg of simvastatin a day, the risk of recurrence
was reduced 50 percent. Men who took a statin dose the equivalent of less
than 20 mg of simvastatin daily saw no benefit"
Statins May Lower Testosterone, Libido - WebMD, 4/16/10 -
"When they compared men on statins to those not, the
men on statins were twice as likely to have low testosterone, regardless of
which of three commonly used thresholds for low testosterone they looked at"
Statins May Be Linked to Diabetes Risk - WebMD, 2/17/10 -
"use of statins increased the risk of type 2
diabetes by 9%. This risk was found primarily among older people; there was
no additional diabetes risk among statin users 60 and under"
Common cholesterol drugs, statins, fight cataracts, too - Science Daily,
and Breast Cancer in Postmenopausal Women without Hormone Therapy -
Anticancer Res. 2009 Dec;29(12):5143-5148 -
"Overall, there was no association between the use of statins and breast
cancer risk odds ratio (OR)=1.3 (95% confidence interval (CI) 0.7-2.5).
However, risk varied by hormone receptor status. Compared to non-users,
obese women who used hydrophobic statins had an elevated risk of
progesterone receptor-negative (PR(-)) breast cancer OR=4.0 (95% CI
1.2-13.8), but not of tumors with other hormone receptor profiles. The risk
for breast cancer was also significantly increased among overweight women
who used hydrophobic statins for less than or equal to 4 years OR=4.1 (95%
CI 1.2-14.4). CONCLUSION: This observational study found an increased risk
of breast cancer related to duration of statins use and PR(-) among
Statins May Soon Be Given to Those With Excess Inflammation - U.S. News,
12/17/09 - "The Food and Drug Administration is
considering expanding the use of cholesterol-lowering statin Crestor to
those who have increased levels of inflammation—but not high cholesterol ...
2.8 percent of folks in the Crestor group developed diabetes compared with
2.3 percent of those who took placebos ... Experts still can't explain why
Crestor would increase the likelihood of diabetes, but other research
suggests that the entire class of statin drugs appears to have this downside
... found a 13 percent increased risk in diabetes in the statin users ...
1.5 percent of the placebo takers had a heart attack or stroke compared with
0.72 percent of the statin takers"
Statins Lower Mortality, but Not Health Services Use - Medscape,
12/10/09 - "After adjustment for clinical and
demographic variables, receipt of statins was associated with a 59%
reduction in mortality"
Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring
Surgery - Science Daily, 11/10/09 - "Use of the
cholesterol-lowering drugs statins for more than a year is associated with a
reduced risk of having gallstones requiring surgery"
Widely Used Cholesterol-lowering Drug May Prevent Progression Of Parkinson's
Disease - Science Daily, 11/9/09 - "Simvastatin,
a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease
from progressing further"
Cholesterol-lowering Medicines May Be Effective Against Cancer - Science
Daily, 11/2/09 - "Our results support the idea that
statins can be used in more ways than just to lower cholesterol," says
Pilon. "Not least that they can prevent the growth of cancer cells caused by
lipid-modified proteins, but also that they can be effective in the
treatment of diabetes and neurological disorders such as Parkinson's."
Statins Show Dramatic Drug And Cell Dependent Effects In The Brain -
Science Daily, 10/28/09 - "Besides their tremendous
value in treating high cholesterol and lowering the risk of heart disease,
statins have also been reported to potentially lower the risks of other
diseases, such as dementia ... statin drugs can have profoundly different
effects on brain cells -both beneficial and detrimental ... simvastatin
reduced the expression of the cholesterol transporter ABCA1 by approximately
80% in astrocytes, while pravastatin lowered expression by only around 50%.
Another interesting difference was that while both statins decreased
expression of the Tau protein -associated with Alzheimer's disease -- in
astrocytes, they increased Tau expression in neurons; pravastatin also
increased the expression of another Alzheimer's hallmark, amyloid precursor
Statin Drugs May Cut Dementia Risk - WebMD, 7/14/09 -
"people who took statin drugs were 58% less likely
to develop dementia than those who did not ... So what is going on? A risk
factor for dementia is high insulin; one theory is that statins may lower
the high insulin levels in the brain. Statins have also been shown to reduce
levels of C-reactive protein (CRP), a marker of inflammation that has been
linked to the pathology that can lead to dementia"
Muscle Damage From Statins May Evade Blood Test - WebMD, 7/6/09 -
"Studies suggest that between 10% and 15% of
patients who take cholesterol-lowering statin drugs like Crestor, Lipitor,
Lescol, Mevacor, Zocor, and Pravachol experience muscle pain as a side
effect of treatment ... Most do not end up with muscle damage, and a simple
blood test is routinely performed to identify patients who do ... But the
new study suggests the test for elevated levels of an enzyme associated with
muscle injury, known as creatine phosphokinase or CPK, may be less accurate
than widely believed ... Our findings call into question whether normal or
mildly elevated levels of serum (CPK) can be used to exclude underlying and
possibly ongoing muscle injury"
Muscle Damage May Be Present In Some Patients Taking Statins - Science
Daily, 7/6/09 - "Although in clinical practice, the
majority of patients with muscle symptoms improve rapidly after cessation of
therapy, our findings support that a subgroup of patients appears to be more
susceptible to statin-associated myotoxicity, suffering persistent
Cholesterol OK? Statins Still Help Heart - WebMD, 7/1/09 -
"Combined data from 10 trials that included more
than 70,000 patients without cardiovascular disease, but with cardiovascular
risk factors, showed a 12% reduction in deaths among patients who took
statins ... The statin group also had 30% fewer heart attacks and 20% fewer
strokes over four years of follow-up"
Statins Can Protect Against Alzheimer’s Disease, According To New Study
- Science Daily, 6/22/09 - "They clearly
demonstrated that treatment with a statin called Lovastatin could prevent
the death of nerve cells under these conditions. The statins not only
prevented cells from dying but also prevented the loss of memory capacity
that normally occurs after such cell death. In a previous study Dolga had
showed that these statins stimulate the protective capacity of tumor
necrosis factor, which is a key player in the brain’s immune response"
- [Abstract] -
is in red yeast rice. See
red yeast rice at Amazon.com.
Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced
Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral
Dysfunction - J Alzheimers Dis. 2009 Mar 6 -
"From these studies we conclude that treatment with lovastatin may provide
protection against neuronal injury in excitotoxic conditions associated with
neurodegenerative diseases including Alzheimer's disease" - Note:
Lovastatin (that's the
generic name and therefore shouldn't be capitalized) is in
red yeast rice. See
red yeast rice at Amazon.com.
Statin Drugs May Protect Against Cancer And Also Result in Fewer Gallbladder
Removals - Science Daily, 5/5/09 - "The research
team found a significant inverse association between having statin
prescriptions filled and the risk of developing HCC. There was a trend
toward stronger risk reduction with longer and more frequent statin
Statins Alter Prostate Cancer Patients' PSA Levels - Science Daily,
4/28/09 - "We found that PSA levels are actually
significantly lower in prostate cancer patients on statins versus prostate
cancer patients not on statins"
Major Statin Study Reveals Several Important Findings For Reducing Prostate
Cancer And Disease - Science Daily, 4/26/09 -
"non-statin users were three times more likely to develop prostate cancer,
suggesting statin use may prevent development of prostate cancer ...
Overall, statin use was not significantly associated with a decreased risk
of developing ED. However, statins were associated with a decreased risk of
ED among older men (>60 years). Men in this age category who used statins
were less likely to develop ED, compared to older men who did not use
statins. Additionally, men who took statins for a longer time were more
protected against developing ED. For example, men who took statins for
nearly nine years or more were 64 percent less likely to develop ED, while
men who took statins for less than three years had about the same risk of
developing ED. compared to men who did not take statins" - See
Statins May Exert Influence On Prostate Cancer Growth By Reducing
Inflammation - Science Daily, 4/26/09 - "men who
were on statins had a 72 percent reduction in risk for tumor inflammation,
and we believe this might play a role in the connection between prostate
cancer and statin use" - See atorvastatin at
Statins May Lower Stroke Risk - Science Daily, 4/15/09 -
"strokes were 18% less likely among patients taking
statins than among those who didn't get statins ... For every drop of 39
mg/dL in LDL "bad" cholesterol, stroke risk dropped by 21%"
Statin study: Lower cholesterol, diminished joy of sex linked - USA
Today, 3/5/09 - "In the study, sexual pleasure sank
along with LDL levels ... Some studies have found that statins improve
sexual function, probably because the pills can improve blood flow to the
genital area, Golomb says. But she says the drugs also may reduce Coenzyme
Q10, a nutrient that helps cells convert oxygen, blood and glucose into
energy. "Orgasm is a high-energy activity," so losing the nutrient could
weaken sexual pleasure, she says" - See
ubiquinol products at Amazon.com.
Aching Back? Cholesterol Medication Might Help - Science Daily, 3/3/09 -
"A new study finds that using statins may be useful
in treatment for degenerative discA new study finds that using statins may
be useful in treatment for degenerative disc ... Lovastatin increased the
synthesis of collagen II, a protein that makes up moveable joints, and
decreased the synthesis of collagen I, a protein that is related to fibrosis
(the formation or development of excess fibrous connective tissue)" -
Note: Lovastatin is the one that red yeast rice
is high in.
Statins Lower Stroke Severity, Improve Recovery - Science Daily, 2/27/09
- "patients who were taking statins before a stroke
experienced better outcomes and recovery than patients who weren't on the
drug — even when their cholesterol levels were ideal"
Statins Cut Deaths From Prostate Cancer - WebMD, 2/26/09 -
"men taking statins were 63% less likely to die from
the disease than men not taking statins ... The high-potency statins were
about 2.5 times more effective at preventing prostate cancer death than the
'Normal' levels of bad cholesterol may be too high - USA Today, 2/1/09 -
"Current guidelines recommend that doctors prescribe
a statin for anyone whose LDL is 100 milligrams per deciliter of blood or
higher ... half of all heart attacks are occurring below 100 (mg/dl) ... the
study supports the wisdom of a push to drive LDL even lower, in many cases
down to 70 mg/dl"
More May Benefit From Cholesterol Drugs - WebMD, 1/13/09 -
"Eight out of 10 middle-aged and older Americans may
benefit from treatment with cholesterol-lowering statin drugs ... All the
participants had elevated levels of high-sensitivity C-reactive protein
(hsCRP) ... Over an average of two years of treatment, participants who took
the statin Crestor had half as many heart attacks, strokes, and deaths from
cardiovascular causes as participants randomly assigned to receive a
Disorders Linked To Statin Drug Use In Some Patients - Science Daily,
JUPITER hits New Orleans: Landmark study shows statins benefit healthy
individuals with high CRP levels - theheart.org, 11/9/08 -
"In a study of individuals with low LDL cholesterol
but elevated C-reactive-protein (CRP) levels, investigators showed that
rosuvastatin (Crestor, AstraZeneca) 20 mg significantly reduced the primary
end point—a composite of nonfatal MI, nonfatal stroke, hospitalization for
unstable angina, revascularization, and confirmed death from cardiovascular
causes—by 44% compared with individuals treated with placebo" -
Note: They seem to be attributing this to the reduction in CRP. At 12
months, the CRP of the 20 mg Crestor group was 2.2. The baseline was 4.2.
That's a (4.2 - 2.2)/4.2 = 47.6% reduction in CRP. Another option to reduce
CRP might be Periostat (low dose doxycycline for periodontal disease). See
my CRP page for other ways to reduce
Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart
Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up, sub-antimicrobial dose
doxycyline significantly reduced
levels by 45.8 percent compared to baseline values (p<0.05). The drug
was also associated with a 33.5 percent reduction in interleukin-6 and a
50 percent reduction in metalloproteinase ... The findings are exciting,
since research is now showing that CRP is both a key marker of
inflammation leading to future acute coronary events, but also that CRP
itself may contribute to the initiation and progression of
Study: Statins help people with normal cholesterol, too - USATODAY.com,
11/9/08 - "A study involving nearly 18,000 patients
has shown for the first time that giving a cholesterol-lowering statin drug
to seemingly healthy people with normal cholesterol can cut their risk of
heart attacks, stroke and death by nearly half"
Statins Lower Prostate Cancer Marker - WebMD, 10/28/08 -
"On average, PSA declined by 4.1% after starting a
statin ... a bigger decrease was seen in men who started out with the
highest PSA levels (2.5 ng/mL or more) -- but only among those who had the
greatest decrease in cholesterol. These men had a 17.4% drop in PSA"
Statins Reduce Dementia & Cognitive Impairment Risk - Physician's Weekly
Article, 10/13/08 - "Patients who had used statins
were about half as likely as those who did not use the drugs to develop
dementia or CIND"
Statins May Prevent Miscarriages, Study Suggests - Science Daily,
Top-selling Cholesterol Drug Does Little For Women, Study Suggests -
Science Daily, 9/17/08 - "Not one of the studies
that included women with a mixture of risk factors for heart attacks
provided statistically significant support for prescribing Lipitor or other
statins to protect against cardiovascular problems. Pfizer’s claims of
clinical proof that Lipitor reduces risk of heart attack in patients with
multiple risk factors for heart disease does not appear to be scientifically
supported for large segments of the female population ... Lipitor’s
advertising repeatedly fails to report that clinical trials were
statistically significant for men but not for women. Unqualified advertising
claims of protection against heart attacks may therefore be misleading"
Statins Lower Risk of Recurrent Stroke in Both Elderly, Younger Patients
- Doctor's Guide, 9/10/08 - "Within each group,
about half of the people received atorvastatin and about half received a
placebo. The participants were then followed for an average of 4.5 years ...
Low-density lipoprotein (LDL) cholesterol was lowered by an average of 61
points during the study for the elderly group, and by 59 points for the
younger group. Those in the younger group reduced their risk for another
stroke by 26% and the elderly group reduced their risk by 10%"
Cholesterol Drugs Lower Risk Of Stroke For Elderly, Too - Science Daily,
Lowering Cholesterol Early In Life Could Save Lives - Science Daily,
8/4/08 - "Our review of the literature convinces us
that more aggressive and earlier intervention will probably prevent
considerably more than 30% of coronary heart disease ... Studies show that
fatty streak lesions in the arteries that are a precursor to atherosclerosis
and heart disease begin in childhood, and advanced lesions are not uncommon
by age 30. Why not nip things in the bud?" Such early signs of heart disease
should be taken as seriously as early signs of cancer or diabetes"
Statins May Prevent Dementia in Older Adults - Doctor's Guide, 7/29/08 -
"People at high risk for dementia who took statins
were half as likely to develop dementia as those who do not take statins"
Statins Are "Remarkably Safe," Says New Review - Medscape, 6/10/08 -
"A new review of the safety of statins has concluded
that these drugs are well tolerated, with their main adverse effects —
myopathy and rhabdomyolysis — occurring very rarely at standard doses"
Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests
- Science Daily, 5/15/08 - "PSA levels were reduced
after starting statin medications and that this decline was proportional to
the decline in LDL cholesterol"
Statins May Reduce Risk for Lung Cancer - Medscape, 5/8/08 -
"Statin use for more than 6 months was associated
with a reduced risk for lung cancer of 55%"
Reduction in Blood Pressure With Statins: Results From the UCSD Statin
Study, a Randomized Trial - Arch Intern Med. 2008 Apr 14;168(7):721-7 -
"Statins modestly but significantly reduced BP
relative to placebo,by 2.2 mm Hg for SBP (P = .02) and 2.4mm Hg for DBP"
Statins Cause Apoptosis
of Esophageal Cancer Cells - Medscape, 4/21/08
Statins Lower Blood Pressure - WebMD, 4/11/08 -
"We found that statins lower both systolic and diastolic blood pressure, and
that the effect extends to patients with pre-hypertension, with normal blood
pressure, and persons not on blood-pressure lowering medications"
Statins May Reduce Risk of Kidney Cancer - Medscape, 2/26/08 -
"Treatment with a statin was associated with a 48%
reduced risk of renal cell carcinoma"
Statins, NSAIDs vs. Prostate Cancer - WebMD, 2/18/08 -
"Men with prostate cancer who take
cholesterol-lowering statin drugs or anti-inflammatory drugs live longer
than those who don't take the drugs ... men who reported ever taking statins
were 41% to 65% less likely to die during the course of the study than men
who didn't. Men who took NSAIDs were 53% to 61% less likely to die than
those who didn't"
Why Patients Stop
Taking Statins and What Can Be Done About It - Medscape, 2/14/08 -
"Another reason why patients might stop taking
lipid-lowering therapy may be sleep disturbance, which has been associated
with statins" - That's something I didn't know. If you are taking
statins, you might want to take them in the morning instead of the evening.
Statins might reduce risk of renal cell carcinoma in humans: case-control
study of 500,000 veterans - Urology. 2008 Jan;71(1):118-22 -
"Statin use was significantly associated with a risk
reduction of renal cell carcinoma of 48% (adjusted odds ratio 0.52"
but Does It Prolong Life? - New York Times, 1/28/08 -
"High-risk groups have a lot to gain ... But
patients at low risk benefit very little if at all. We end up overtreating a
lot of patients ... This month, The Journal of the American College of
Cardiology published a report combining data from several studies of people
65 and older who had a prior heart attack or established heart disease. This
“meta-analysis” showed that 18.7 percent of the placebo users died during
the studies, compared with 15.6 percent of the statin users ... This
translates into a 22 percent lower mortality risk for high-risk patients
The Association Between Statins and Cancer Incidence in a Veterans
- J Natl Cancer Inst. 2008 Jan 8 - "After
multivariable adjustment, a statistically significantly decreased risk of
all cancers was also associated with increasing statin use"
Statins for All Adults with Diabetes? - WebMD, 1/10/08 -
"One-third fewer people with type 1 or type 2
diabetes would suffer heart attacks or strokes if they took
cholesterol-lowering statin drugs"
Statin Drugs May Cut Cancer Risk - WebMD, 1/8/08 -
"The veterans were followed for five years, on
average. During that time, 9% of those taking statins were diagnosed with
cancer, compared with 13% of those not taking statins, VA records show"
Elderly CHD Patients and Statins - Medscape, 1/3/08 -
"the use of statins for secondary prevention in
elderly patients with documented CHD reduced all-cause mortality 22% and
reduced CHD mortality 30%. Nonfatal myocardial infarction was reduced 26%,
the need for revascularization 30%, and stroke 25%"
Statin Use Tied to Fewer Relapses in Prostate Cancer - oncologystat.com,
11/26/07 - "Men who happened to be on statins when
given radiotherapy for prostate cancer were significantly more likely to be
disease free 10 years later"
CORONA: Little Clinical Benefit Seen in First Major Statin Trial in HF -
Medscape, 11/6/07 - "Over a median follow-up of 33
months, there were no significant differences in the primary end point or in
all-cause mortality, the rate of coronary events (which included sudden
death, fatal or nonfatal MI, percutaneous coronary intervention [PCI] or
coronary arterial bypass graft [CABG], resuscitated cardiac arrest, and
hospitalization for unstable angina), effects on NYHA class, or the rate of
newly diagnosed diabetes ... Despite the lack of difference in the primary
end point, there were significant reductions in levels of CRP; however, they
were not decreased to what would be considered a low level ... This does
bring into question whether higher doses of rosuvastatin could have
additional clinical benefit" - Note: Statins do little to increase
HDL which some studies imply may be more important. Also, statins have been
shown to decrease co-enzyme Q10. I would have liked to see the results if
they had added niacin to increase HDL and co-enzyme Q10.
Statins May Fight Prostate Cancer - WebMD, 10/29/07 -
"Overall, 76% of men who took statins were alive and
without cancer 10 years after treatment vs. 66% of those who didn’t"
Cholesterol-lowering Medicine Make Radiation More Effective At Curing
Prostate Cancer? - Science Daily, 10/29/07 -
"Patients with prostate cancer who receive high-dose radiation treatment and
also take statin drugs commonly used to lower cholesterol have a 10 percent
higher chance of being cured of their cancer at 10 years after diagnosis (76
percent), compared to those who don't take these medications (66 percent)"
Statin Use Linked to Better Blood Pressure Control - Medscape, 10/23/07
- "After adjustment for demographics, body mass
index, diabetes, smoking, exercise, low-salt diet, and antihypertensive
medications, the odds ratio for having blood pressure under control was 1.46
for statin users compared with nonusers"
Statins Cut Gallstones Risk - WebMD, 10/16/07 -
"The study suggested that overall, current statin use slashed the risk of
having gallbladder removal surgery by 18% -- no matter how long a woman had
been taking the drug ... Women with diabetes who had been taking statins for
two or more years reduced their risk of surgery by 75% ... Statins improve
insulin resistance in people with diabetes but not in nondiabetics"
Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's
Weekly Article, 10/15/07 - "there appears to be a
strong reduction in dementia and Parkinson’s disease incidence attributed to
the use of simvastatin, a cholesterol lowering drug. The researchers also
observed a moderate reduction in incidence of these conditions with
atorvastatin, another cholesterol-lowering drug"
Can Statins Benefit Patients With Low LDL-Cholesterol Levels? -
Physician's Weekly, 10/15/07 - "Investigators
reviewed more than 6,000 patients with LDL levels of less than 60 mg/dL.
After receiving a statin medication, patients with low LDL levels had better
survival rates than those who did not receive the agent"
Statins Reduce Loss Of Function, Keeping Old Lungs Young -- Even In Smokers
- Science Daily, 10/12/07 - "subjects taking statins
experienced a markedly slower annual decline in lung function. In FEV1,
statin users lost 10.9 ml on average, whereas nonusers lost an average of
23.9 ml each year--more than twice that of the statin group. Similarly,
statin users lost an average of 14 ml a year in FVC, whereas nonusers lost
an average of 36.2 ml ... the observed effect may be attributable to
statins' ability to reduce inflammation and smoking-induced injury in the
lung, as well as their capacity to reduce serum levels of C-reactive
protein, which relates to systemic inflammation, and to protect against
Statin Drugs: Heart Benefits Last Long - WebMD, 10/10/07 -
"Men who got inactive placebo pills during the study
had a 15.5% chance of heart attack or heart death 10 years after the study
ended. Those who got five years of statin treatment had only an 11.8% chance
of heart attack or heart death. They also had a lower risk of heart disease"
Low-Dose Aspirin Plus Statins Protects Against Colorectal Cancer -
Medscape, 10/4/07 - "Dr. Brenner's group observed a
modest risk reduction of colorectal cancer among regular users of low-dose
aspirin (adjusted odds ratio = 0.77). A stronger association was found with
regular use of statins (OR 0.65). The strongest risk reduction was seen in
subjects who used combination low-dose aspirin and statins (OR 0.63),
especially if both drugs were used for at least 5 years (OR 0.38)"
Statins May Help Alzheimer's Patients - washingtonpost.com, 9/11/07 -
"Those patients who had taken statins before they
died showed significantly lower levels of tangles in their brains ... Our
data says these drugs appear to be doing something in the human brain ...
Whether this will translate into behavioral changes, we can't say ...
subjects had taken statins for only five years or less. It may be that
longer use of statins would offer more protection"
Use of Statins and Blood Pressure - Am J Hypertens. 2007
Sep;20(9):937-941 - "Compared with people not using
statin medication, significantly more statin users had their blood pressure
under control (52.2% v 38.0%). After adjustment for demographic factors,
statin users were two times (95% confidence interval [CI], 1.46 to 2.72)
more likely to have their blood pressure under control (<140/90 mm Hg) than
nonusers. After further adjustment for body mass index, diabetes, smoking,
exercise, low-salt diet, and antihypertensive medications, the likelihood of
having blood pressure under control remained more likely among statin users
(odds ratio, 1.46; 95% CI, 1.05 to 2.05)"
Statins May Cut Alzheimer's Disease - WebMD, 8/27/07 -
"participants who had taken statins were 80% less
likely to have brain changes typical of Alzheimer's disease than those who
hadn't taken statins"
Statins May Cut Colon Cancer Recurrence - Medscape, 7/26/07 -
"Just 6 of 89 patients (6.7%) treated with any
statin relapsed, as opposed to 43 of 269 (16%) patients with no statin use"
Older Patients Reap Positive Benefits With High Dose Statins, Study Finds
- Science Daily, 7/3/07 - "The study participants
had a relative reduction in risk of 19 percent for a major cardiovascular
event with high-dose compared with low-dose atorvastatin. The important
feature is that this occurred without any evidence of increase in risk from
the high dose"
Common Drugs Cut Diabetes Nerve Damage - WebMD, 6/22/07 -
"protection was 35% for statins and 48% for fibrates --
statistically the same protection -- and these effects were independent of
blood sugar control, height, age, other things associated with neuropathy"
Statins May Cut Prostate Cancer Deaths - WebMD, 5/21/07 -
"the greater the men's cholesterol decrease, the more
their PSA levels dropped"
Treating the metabolic syndrome - Expert Rev Cardiovasc Ther. 2007
May;5(3):491-506 - "appropriate treatment of MS
components often requires pharmacologic intervention with insulin-sensitizing
agents, such as metformin and
statins and fibrates, or
angiotensin-converting enzyme inhibitors and
angiotensin II receptor blockers are
the first-line lipid-modifying or antihypertensive drugs"
Use Linked With Decreased Prostate Cancer Mortality Rates; Lower PSA Levels
- Science Daily, 5/20/07 - "PSA levels declined by 1.1
percent for every 10 mg/dl decrease in LDL ... Reviewing PSA levels among statin
users screened in the Finnish Prostate Cancer Screening Trial, researchers from
Helsinki found a decrease in prostate cancer incidence in this group ... A
significant decrease was found in the incidence of T3 cancers ... Non-statin,
lipid-lowering drugs were not associated with incidence, stage or grade"
Cholesterol Drugs May Fight Lung Cancer - WebMD, 5/7/07 -
"People who take cholesterol-lowering statin drugs for
more than six months -- even smokers -- cut their lung cancer risk by 55% ...
Taking the drugs for four or more years cut lung cancer risk by 77%"
Drugs May Reduce Risk Of Heart Failure, Sudden Cardiac Death, New Study Suggests
- Science Daily, 5/1/07
Effects of Statin Use on Muscle Strength, Cognition, and Depression -
Medscape, 4/30/07 - "Statin nonusers tended to perform
worse on each outcome measure"
Statins Take on Advanced Prostate Cancer - Physician's Weekly, 4/2/07 -
"The use of statin drugs “was not associated with risk
of prostate cancer overall but was associated with a reduced risk of advanced
(especially metastatic or fatal) prostate cancer.” ... The relative risk was
0.60 for less than five years of statin use and for 0.26 for five or more years
Statins Protect Against Prostate Cancer - Doctor's Guide, 3/27/07 -
"Overall, prostate cancer incidence was significantly
lower for statin users than non-users (4.0% vs 8.0%, respectively). A
significant dose-response relationship was seen for the total cumulative
quantity of statin users and incidence of prostate cancer"
Cholesterol Busting Statins Also Reduce Blood Pressure - Science Daily,
3/8/07 - "the use of statins did produce a drop in blood
pressure. The overall effect of the use of statins was a 1.9 mmHg reduction in
systolic blood pressure and 0.9 mmHg in diastolic blood pressure. The effect was
even more pronounced in patients with high blood pressure (systolic over 130
mmHg) who showed an average drop of 4.0 mmHg if treated with statins"
Should Everyone Be on
a Statin? - Medscape, 3/6/07 -
"Patients without contraindications should be considered
for treatment with statins if their risk for cardiovascular events exceeds 20%
over a 10-year period. Patients with a 10-year risk for cardiovascular events
under 10% probably will not benefit from statin treatment. The art of medicine
applies to the large group of patients who fall between a 10% and 20% risk for
events over 10 years. The current study suggests that a significant reduction in
morbidity may be achieved in these patients, but if a reduction in mortality
associated with statin therapy in this population exists, many patients will
require statin therapy over significant time periods to achieve a benefit"
Statin Therapy Cuts Bad Cholesterol Unprecedented 70% - Doctor's Guide,
2/27/07 - "40 mg of rosuvastatin and 10 mg ezetimibe ...
Crestor and Zetia reduced mean LDL-C by an unprecedented 70%"
Biological Aging Predicts Heart Attack - WebMD, 1/11/07 -
"People who age fast -- as measured by DNA shortening --
have a higher heart disease risk. Statin drugs may help ... Pravachol -- one of
the "statin" family of cholesterol-lowering drugs -- dramatically lowered the
heart disease risk of people with shorter telomeres. But the drug seemed to have
little effect on heart disease risk in people with the longest telomeres"
Do statins have a
beneficial effect on the kidney? - Medscape, 1/4/07 -
"Statins appear to have a small beneficial effect on the
rate of kidney function decline (particularly in patients with cardiovascular
disease), and proteinuria"
Statins vs. Advanced
Prostate Cancer - WebMD, 12/19/06 - "Overall, statin use didn't appear to
sway the men's chances of being diagnosed with prostate cancer ... Men taking
statin drugs were about half as likely to have advanced prostate cancer as those
not taking statins"
Statin Drugs May Help
the Healthy - WebMD, 11/27/06 -
"people without heart disease or stroke who took statins
had a nearly 30% lower risk of coronary heart event, including heart attack, and
14% lower risk of stroke compared with those who didn't"
More People Could
Benefit From Statins - WebMD, 11/9/06 -
"They found treatment with a generic statin to be
cost-effective, even for people as young as 35 or as old as 85, whose annual
risk of having a major heart or stroke event was as little as 1% ... generic
statins could save patients in the U.S. as much as $1,800 per year"
Use Slows Lung Function Decline In Smokers And Former Smokers - Science
Study: Statins Increase Life Expectancy - Intelihealth, 10/10/06 -
"We were surprised to find that statin users actually
lived an average two years longer despite the patients having more health risk
factors and being older than non-statin users"
Low-dose statin therapy
reduces risk of CHD in Japanese subjects by 33% - Medscape, 9/28/06 -
"the addition of pravastatin 10 mg to a low-fat diet rich in omega-3 fatty acids
reduces the risk of CHD in Japanese individuals with moderately elevated
cholesterol levels by 33%, approximately the same reduction observed in US and
European primary-prevention trials that have used larger statin dose"
Cholesterol Drugs May Avert Cataracts - WebMD, 6/20/06 -
"Those who took Zocor had a 72% lower risk of nuclear
cataracts. Those who took Lipitor had a 27% lower risk. Those who took
Pravachol, Lescol, and Mevacor had a combined 33% lower risk"
Statin Use Associated With Marked Decrease in Kidney Cancer Among US Veterans
- Doctor's Guide, 5/25/06 - "statins are associated with
a 44% risk reduction of kidney cancer"
Statin Therapy Benefits Hypertensive and Non-Hypertensive Patients -
Doctor's Guide, 5/18/06 - "Overall, pooled results
showed that statin therapy reduced cardiac deaths by 24%"
Cholesterol-lowering Drugs Not Associated With Increased Breast Cancer Risk
- Science Daily, 5/18/06
Statins May Improve Circulation In The Retina
- Science Daily, 5/9/06 - "Among patients taking
statins, intraocular pressure was reduced 90 minutes after taking the
medication and at the seven-day mark. Blood velocity (speed) and blood flow
were significantly increased in patients who had taken statins for seven
Erectile Dysfunction and Statin Treatment - Medscape, 3/21/06 -
"Simvastatin was found to cause impotency in five
men with coronary artery disease, and within 1 week of discontinuing
simvastatin, sexual function was restored. The Australian Adverse Drug
Reactions Committee reported 42 cases of ED associated with simvastatin.
In contrast, in one study in men aged 49.7 years and isolated
hypercholesterolaemia [low-density lipoprotein (LDL)-C 4.3 mmol/l] as a risk
factor which used penile Doppler ultrasound in a per protocol analysis of
50% of the cohort of 18 patients (n = 9), atorvastatin therapy was
associated with improvement in erectile function"
Statin Withdrawal Hard on the Heart - WebMD, 3/14/06 -
"people who discontinued taking the drugs
experienced rapid rises in both C-reactive protein (CRP) and LDL cholesterol
Of Statins Shows Improvement In Erectile Performance Of Some Men Who
Previously Did Not Respond Well To Viagra - Science Daily, 2/23/06 -
"There did seem to be some improvement for those who
received Lipitor versus the placebo ... We theorized that if you could make
the edothelium healthier through the use of statins -- so that there is more
nitric oxide available -- you would improve the endothelial dysfunction and
Viagra would work better for the patient"
Cholesterol Drugs May Slow Alzheimer's - WebMD, 11/17/05 -
"Those taking cholesterol drugs had the smallest
drop in test scores ... No one was assigned to take any drug. The
researchers just tracked the patients' medications and test scores"
Statin Drug Good Bet After Heart Attack - WebMD, 11/15/05
Scientists Use Statins To Overcome Learning Disabilities In Mice -
Science Daily, 11/11/05 - "UCLA scientists used
statins, a popular class of cholesterol drugs, to reverse the attention
deficits linked to the leading genetic cause of learning disabilities"
40-Point Cholesterol Drop=20% Lower Heart Risk - WebMD, 9/27/05 -
"for every 40-point drop in "bad" LDL (low density
lipoprotein) cholesterol sustained over a five-year period, the use of
statins reduced the risk of heart attack, stroke, and other heart-related
complications by nearly 20%"
Cholesterol-Lowering Drugs Also Good for Bones - WebMD, 9/26/05
Statin Treatment Within First 24 Hours After Heart Attack Cut Mortality By
Half - Doctor's Guide, 8/29/05 -
"early treatment with a statin drug within 24 hours
of having a heart attack reduced in-hospital mortality rates by over 50%"
Statins Don't Cut Dementia Risk - Clinical Psychiatry News, 8/05 -
"Initial analyses of the investigators' data suggested that statin use
lowered the risk of dementia. But that link disappeared in further analyses
that adjusted for covariates, particularly subject age and sex"
Cholesterol Drugs May Help After Bleeding Stroke - WebMD, 7/28/05
Statin Therapy May Lower Mortality in Heart Failure Patients - Doctor's
Guide, 7/25/05 - "during the study period, heart
failure patients on statin therapy had a risk of death that was 22% lower
than the patients receiving the other drugs"
Statins Not Associated with Reduced Dementia Risk - Doctor's Guide,
7/11/05 - "Participants were on average 75 years of
age, and statin use was assessed for a median of 5 years. Statin exposure
may need to occur earlier in adulthood or for longer periods to prevent
MRI Scan Reveals How Cholesterol Drugs Work - WebMD, 7/5/05 -
"20 milligrams or 80 milligrams of Zocor daily ...
After a year and a half of treatment, MRI scans showed that both groups
ended up with similar reductions in plaque size, regardless of the strength
of their statin dose ... Reduction in the size of blood vessel wall plaque
was greater in people whose LDL cholesterol dropped below 100 mg/dl"
Large Study Shows Link Between Statin Use and Risk of Lymphoma: Presented at
ICML - Doctor's Guide, 6/9/05 -
"Use of statins is associated with a decrease in the
risk of developing any type of lymphoma"
The Role of Statins in Preventing Stroke - Medscape, 6/7/05 -
"statins reduce stroke through cumulative
improvements in a number of different components of atherosclerosis
including effects on the endothelium, thrombosis, plaque stability, and
through anti-inflammatory effects"
Cholesterol-Lowering Drugs Still Underused - WebMD, 5/31/05 -
"Only half of the people at moderate or high risk
for heart disease are getting the recommended cholesterol-lowering drugs
that can reduce their risk of a heart attack or death"
Cholesterol Drugs May Prevent Colon Cancer - WebMD, 5/25/05 [Abstract]
"people who took cholesterol-lowering statin drugs
for five years cut their colon cancer risk in half"
Amlodipine and Atorvastatin Combination May Help Relax Arteries -
Doctor's Guide, 5/20/05 - "the calcium channel
blocker amlodipine (Norvasc) and the cholesterol-lowering agent atorvastatin
(Lipitor) both reduce arterial stiffness in the small arteries ... Stiff
arteries are old arteries ... Relaxing the arteries is beneficial for
Statin Use Linked to 51% Reduction in Breast Cancer - Medscape, 5/20/05
"The beneficial effect is seen in more than four
years of statin use ... In both the prostate and lung cancer studies, there
was a 48% to 54% risk reduction in cancer associated with statin use"
Statin Use Associated with Lower Risk of Pancreatic and Esophageal Cancer
- Doctor's Guide, 5/19/05 - "The odds ratio was 0.44
(95% confidence interval 0.36 – 0.53) for esophageal cancer and 0.41 (95%
confidence interval 0.31 – 0.51) for pancreatic cancer. This translates into
a reduction in cancer risk of 56% and 59%, respectively"
Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 -
"During a six-year period, women who used statins
reduced their risk of breast cancer by more than half (51%) compared with
nonusers ... Statin users were 48% less likely to develop lung cancer than
nonusers ... statin use reduces the rate of prostate cancer by 54%"
Next Alzheimer's Disease Drug: Lipitor? - WebMD, 5/9/05 -
"How could Lipitor help Alzheimer's patients? Excess
cholesterol in the brain seems to play a role in Alzheimer's disease
Combination Therapy The Next Wave For Diabetic Dyslipidemia - Doctor's
Guide, 5/2/05 - "Ezetimibe and prolonged-release
nicotinic acid show the most promise so far when combined with a statin ...
extended-release form of nicotinic acid (Niaspan) ... taking 1000 mg or 1500
mg per day experienced increases in serum high-density lipoprotein (HDL)
cholesterol levels of 19% and 24%"
Statins Urged for Diabetic Patients - Doctor's Guide, 5/2/05 -
"diabetics who are older than 40 years of age whose
total cholesterol exceeds 3.5 mmol/L (135 mg/dL) should be placed on statin
therapy to achieve a 30% to 40% reduction in LDL level, regardless of their
baseline LDL level and even if they do not have overt cardiovascular
Men Who Take Statins Slash Risk of Advanced Prostate Cancer - Doctor's
Statins Lower Prostate Cancer Risk - WebMD, 4/18/05 -
"Compared with men who didn't take
cholesterol-lowering drugs, those who did take them had nearly one-half the
risk of developing advanced prostate cancer. Risk decreased with increasing
duration of use"
Cholesterol Drugs Help Stroke Recovery - WebMD, 4/12/05 -
"Unless there are medical reasons not to take the
drugs, all patients who suffer a stroke should be put on statins ... people
started on statin drugs within a week of a stroke were one-and-a-half to
more than twice as likely to recover and go home within 45 days as those who
were not given the drugs"
High Cholesterol May Speed Prostate Cancer - WebMD, 3/17/05 -
"Our data support the notion that
cholesterol-lowering drugs -- which are widely used and fairly safe -- might
be effective in prevention of prostate cancer, or as an adjunctive therapy
... elevated cholesterol levels did not stimulate new prostate cancers but
promoted tumor growth"
- Study: Cholesterol drugs
fight heart disease - MSNBC, 3/8/05 -
"Taking very high doses of a drug to push
cholesterol to very low levels can help people with heart disease avoid
strokes and heart attacks, but also can cause liver problems that limit the
ability to tolerate such intensive treatment"
Statin Therapy Lessens Complications in Angioplasty Patients - Doctor's
Grapefruit Juice and Medication Can Be a Deadly Mix
- Doctor's Guide, 1/18/05 -
"reported on a man from a northern climate who moved
to Florida for the winter ... and began drinking two to three glasses of
grapefruit juice each day. Two months later the man died, the victim of a
deadly interaction between grapefruit juice and his cholesterol-lowering
- Cholesterol Drugs
May Lower Alzheimer's Risk - WebMD, 1/10/05 -
"long-term use of the cholesterol-lowering drugs may
help reduce risk of memory-robbing deposits and Alzheimer's disease"
- If Bush Needs a
Cholesterol Drug, Do You? - WebMD, 12/14/04 -
"his total cholesterol level was listed as 170 mg/dL, which is considered
within the normal range ... people with normal total cholesterol but low HDL
"good" cholesterol levels (below 40) had a 37% reduction in heart attack
risk over five years by taking a statin"
Cholesterol-lowering Drug May Slow Alzheimer's Progression
- Science Daily, 11/17/04 -
"The cholesterol-lowering drug atorvastatin slowed
down mental decline and improved depressive symptoms in people with
Statins May Lower Blood Pressure - Doctor's Guide, 11/20/04 -
"simvastatin was associated with a 2.79-mm Hg decrease in systolic blood
pressure and a 2.67-mm Hg drop in diastolic blood pressure, while
pravastatin led to a 2.47-mm Hg decline in systolic blood pressure and a
2.47-drop in diastolic blood pressure"
Medication: Are High Doses Better? - WebMD, 11/1/04 -
"The high-dose cholesterol medication group appeared
to fare better. Their risk of heart disease events - including death, heart
attack, and severe chest pain -- was reduced by 17% compared with people
receiving usual-care treatment"
Experts: Fewer Take Statins Than Should - Intelihealth, 10/18/04 -
"About 13 million Americans take statins -- roughly
one-third of the number for whom they're recommended ... Clinton's case
shows the need for educating more doctors to treat cholesterol more
aggressively ... The president's doctors didn't even know how to manage
No Negative Effects on Bone Health Seen in Women Taking Statins
- Doctor's Guide, 10/5/04
Statin Use Protects Heart Failure Patients Against Mortality Regardless of
Cholesterol Levels - Doctor's Guide, 9/16/04 -
"As possible mechanisms for this benefit, it has been
suggested that statins help improve endothelial function, including
increasing endothelial nitric oxide expression, they appear to improve
autonomic nervous system function and reduce cardiac hypertrophy and
Statins, But Not Cholesterol, Appears to Impact Morbidity in Heart Failure
- Doctor's Guide, 8/30/04 -
"Statin use is associated with improved outcomes"
Cholesterol-Lowering Drugs Work for Years - WebMD, 8/26/04 - "Overall,
there was a 24% reduction in heart attack deaths and a 17% reduction in
deaths from other cardiovascular causes among patients taking the
cholesterol-lowering drug for 10 years compared with five years"
HMG-CoA reductase inhibitors prevent bone loss in patients with Type 2
diabetes mellitus - Diabet Med. 2004 Sep;21(9):1020-4 -
"there was a significantly smaller annual decrease of
the radial BMD in the HMG-CoA group"
Statin use in Type 2 diabetes mellitus is associated with a delay in
starting insulin - Diabet Med. 2004 Sep;21(9):962-7 -
"The use of statins is associated with a delay in
starting insulin treatment in patients with Type 2 diabetes initially
treated with oral antidiabetic agents"
- Statin Drugs
May Protect Children's Hearts - WebMD, 7/20/04
Statins May Provide Anti-Inflammatory Benefit in Patients with Rheumatoid
Arthritis - Doctor's Guide, 7/5/04 -
"Primary outcome measures were change in disease
activity score (DAS28) ... the DAS28 improved significantly in the group
receiving atorvastatin compared with placebo ... In addition, C-reactive
protein declined by 50%"
- Statin Therapy: An
Expert Interview With Eliot A. Brinton, MD - Medscape, 6/24/04
Long-Term Use of Statins May Protect Against Glaucoma
- Doctor's Guide, 6/22/04
- Atorvastatin Reduces
Blood CoQ10 Levels - Medscape, 6/22/04 - "Even
brief exposure to atorvastatin causes a marked decrease in blood CoQ10
concentration ... Widespread inhibition of CoQ10 synthesis could explain the
most commonly reported adverse effects of statins, especially exercise
intolerance, myalgia, and myoglobinuria" - See
ubiquinol at Amazon.com.
Drug May Help Rheumatoid Arthritis - WebMD, 6/17/04 -
"After six months, the patients who took Lipitor did a bit better than the
others. They had lower scores on a medical index of rheumatoid arthritis
activity ... In addition, the Lipitor group had lower levels of two markers
of inflammation -- sed rate and C-reactive protein"
Drugs May Fight Glaucoma - WebMD, 6/14/04 - "men
who had used statins for two or more years were 40% less likely to develop
glaucoma than the others ... Use of other, non-statin cholesterol-lowering
drugs was also associated with a 41% lower incidence of glaucoma ... use of
statins can also lower the risk of developing age-related macular
degeneration, the most common cause of blindness among people over 65"
New Study Links Common Cholesterol-Lowering Drugs To Reduced Prostate Cancer
Risk - Science Daily, 6/8/04 -
"men who have taken any amount of these drugs, known
as statins, have a 58 percent lower risk of prostate cancer than men who
have taken none at all"
- Statin Drugs
May Cut Colon Cancer Risk - WebMD, 6/7/04 -
"When they added in those factors, "use of statins was still associated with
a 46% reduction in risk.""
Drugs: Cancer Fighters? - WebMD, 4/26/04 -
appeared to decrease the risk of
breast cancer by 30% in postmenopausal women"
Statin Prescriptions Consistently Low in Elderly Patients at Cardiovascular
Risk - Doctor's Guide, 4/21/04 -
"Our observed low prescription rate of statin
therapy adds to a growing body of literature demonstrating that statin
therapy is substantially underused"
- Nearly All With
Type 2 Diabetes Need Statins - WebMD, 4/19/04 -
"no matter how low the cholesterol count, nearly all
people with diabetes should take these cholesterol-lowering drugs"
- Statins Fight
Vision Loss - WebMD, 4/15/04
Statins and Aspirin May Protect Against Severe Vision Loss in Elderly
- Doctor's Guide, 4/13/04 - "those patients already
taking statins were half as likely as those without statins to develop the
more severe wet AMD, caused by the growth of new blood vessels underneath
Inverse Relationship Observed Between Statin Treatment and Risk of Hip
Fracture - Doctor's Guide, 3/12/04 -
"The risk of hip fracture decreased as the number of
statin prescriptions increased ... 0.72 ... for subjects who redeemed more
than 3 statin prescriptions"
Statin Dosing Rarely Meets Recommended Therapeutic Goals
- Doctor's Guide, 3/9/04 - "in clinical practice
statins are routinely underdosed, thus significant numbers of patients never
receive the protective benefits of these agents"
Lipid-Lowering Decreases All-Cause Mortality
- Medscape, 3/8/04 -
"Patients were randomized to 40 mg pravastatin
(standard therapy) or 80 mg atorvastatin (intensive therapy) ... All-cause
mortality was reduced by 28% in the aggressive-treatment arm ... At the time
of randomization, the median LDL cholesterol level in each group was 106
Preoperative Statin Therapy Benefits Patients Undergoing Vascular Surgery
- Doctor's Guide, 3/8/04 -
"preoperative treatment with statins appears to be
associated with a shorter hospital stay, improved long-term survival, and
trends towards fewer myocardial infarctions (MIs) and combined
cardiovascular end points"
Intensive versus moderate lipid lowering with statins after acute coronary
syndromes - NEJM, 3/8/04
Cholesterol Drugs Lower Stroke Risk - WebMD, 3/4/04 -
"Statin therapy should now be considered routinely
for all patients at high risk of stroke, irrespective of their initial
cholesterol concentrations or the presence of heart disease"
Statin Therapy Stops Plaque Buildup - WebMD, 3/2/04 -
"compared the effects of intensive statin therapy using 80 mg daily of
Lipitor vs. a more moderate approach using 40 mg of Pravachol ... the most
significant finding was that plaque buildup within the arteries stalled
among the patients on high-dose statin therapy and there was no progression
of atherosclerosis in this group"
- Statins May
Help Prevent Bone Fractures - WebMD, 1/26/04 -
"statin users had a 38%-81% lower risk of hip bone fractures and a 5%-51%
lower risk of nonspinal fractures ... statin use was associated with a 57%
reduction in the number of hip fractures reported and a 31% reduction in
Statins: A New Therapy for Depression? - Physician's Weekly, 12/8/03 -
"adult patients with underlying coronary artery
disease (CAD) who continuously used statins were 30% to 40% less likely to
be at risk for depression, anxiety, and hostility"
Reason for concern? - Wellness Insider, 11/25/03 -
"Dr. Golomb feels the potential side effects of
statins, which include liver dysfunction, muscle pain (rhabdomyolysis), and
potentially, muscle breakdown, have been significantly downplayed. She also
feels that statins, especially at higher doses, contribute to memory loss
and to the depletion of coenzyme Q10, a naturally occurring antioxidant-like
nutrient vital to the production of energy"
Severe Hepatotoxicity Rare in Patients With Elevated Liver Enzymes on Statin
Therapy - Doctor's Guide, 10/31/03
Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
significantly more effective than atorvastatin, simvastatin, and pravastatin
in improving the ratios of total cholesterol to high-density lipoprotein
Rosuvastatin 10-40 mg Safe and Well Tolerated Compared to Other Statins
- Doctor's Guide, 10/1/03 - "Minor adverse events
associated with the use of rosuvastatin included myalgia in 2.1%, asthenia
in 1.2%, nausea in 1.4%, dyspepsia in 0.6%, headache in 1.1%, insomnia in
0.8%, abdominal pain in 1.2%, diarrhoea in 1.1%, constipation in 1.1%, and
flatulence in 0.9%"
Statins Used to Treat High Cholesterol and Osteoporosis
- Doctor's Guide, 9/30/03 -
"simvastatin acts as a double therapeutic weapon by
blocking the conversion of HMG-CoA to mevalonate. Not only does this action
increase new bone formation via the stimulation of osteoblasts, but it also
prevents the production of cholesterol"
Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol
- Doctor's Guide, 9/30/03 - "Most significantly,
while the PWV remained unchanged in the pravastatin and non-statin group, it
was moderately decreased in the simvastatin group and remarkably reduced in
the fluvastatin group ... Dr. Ichihara theorized that lipophilic statins,
such as fluvastatin, reduce
aortic stiffness via three mechanisms -- decreasing serum total
cholesterol levels without reducing serum high-density lipoprotein levels,
providing powerful scavenging reactive oxygen species, as well as reducing
serum levels of low-density lipoprotein and C-reactive protein"
Statins may play a role in the treatment of inflammatory rheumatic diseases
- Doctor's Guide, 9/28/03 - "the administration of
simvastatin for 8 days was associated with a rapid and significant reduction
in proteinuria levels in the three patients with
SLE, as well as in the 2 patients with systemic vasculitis. In the five
RA, atorvastatin for 8 days was associated
with a reduction in C-reactive protein
levels and clinical improvement ... statins may have an important
therapeutic potential for different inflammatory diseases" - Note:
Red yeast rice is a non-prescription statin
but check with your doctor. See
red yeast rice at Amazon.com.
Crestor (Rosuvastatin Calcium) Available in US For Treatment of Elevated
Cholesterol - Doctor's Guide, 9/16/03 -
"Crestor is available in 5 to 40 mg doses in
pharmacies nationwide ... In clinical trials, Crestor lowered LDL
(low-density lipoprotein) cholesterol or "bad" cholesterol by 45 to 63
percent (7 percent for placebo) and increased HDL (high-density lipoprotein)
cholesterol or "good" cholesterol by 8 to 14 percent (3 percent for
Heart Protection Study Implications for Lipid Management Guidelines and
Practices - Doctor's Guide, 9/16/03 -
"While Heart Protection Study (HPS) findings support
aggressive lowering of low-density lipoprotein (LDL) cholesterol levels and
suggest optimal levels well below current recommendations, failure to
achieve current goals for LDL cholesterol is common ... HPS findings
demonstrated that a reduction of major vascular events extended even to CAD
patients with initial LDL cholesterol levels <100 mg/dL using simvastatin 40
mg, suggesting that the optimal LDL cholesterol level is below target levels
established in current guidelines ... rosuvastatin is more effective than
other statins in reducing LDL cholesterol"
Drug May Ease Intermittent Claudication
- WebMD, 9/2/03 -
"Lipitor has the added benefit of improving walking
ability in people with intermittent
claudication, a condition caused by blocked leg arteries that leads to
cramping and fatigue in the legs and buttocks during exercise, such as
- Only Half of Patients
Receiving Statins Achieve Maximum Benefit
- Medscape, 9/2/03 -
"less than than half of patients started on a
statin are treated to goal, and thus the promise of statins for
cardiovascular disease prevention may be largely unrealized ... the problem
seems to be caused by poor physician follow-up ... Compliance is another
- Note: Red yeast rice is a non-prescription
red yeast rice at Amazon.com.
- Statins Benefit
Diabetics, Regardless of Cholesterol Levels
- Medscape, 8/13/03 - "These results show that
simvastatin therapy leads to significant risk reductions for vascular events
in type 2 diabetic patients, even if they don't have diagnosed coronary
disease or high cholesterol levels. The authors estimate that 5 years of
treatment would prevent about 45 major vascular events per 1000 patients and
suggest that statins should be offered to high-risk diabetic patients
regardless of their cholesterol levels"
Heart Protection Study Supports Use of Statins In Elderly, Women, and Those
With Low LDL - Doctor's Guide, 8/1/03 -
"statin treatment significantly decreased the risk
of cardiovascular morbidity and mortality (primary endpoint) and "any major
vascular event," including non-fatal myocardial infarction, stroke, and need
for revascularisation procedures ... In older adults compared to younger
adults, the HPS trial found similar statin benefits, with about a 25%
reduction in major vascular events regardless of age"
- Statins Help
Ease Heart Failure - WebMD, 7/28/03 -
"People with heart failure may benefit from
treatment with cholesterol-lowering statin drugs even if their cholesterol
levels are normal ... One group took 5 mg of the statin Zocor for four weeks
followed by 10 mg for 10 weeks ... standard dose of Zocor in the U.S. to
treat high cholesterol is 40 mg ... researchers found significant
improvements among the patients taking the statin. Their average level of
functional heart impairment dropped from 2.39 to 2.04 on a scale of 1 to 4
... left ventricular ejection fraction, a measure of heart function, rose
from 34% to 41%" - Note: Red yeast rice
is a non-prescription statin. See
red yeast rice at Amazon.com.
Physicians Not Aggressive Enough In The Prescribing and Monitoring of
Lipid-Lowering Agents - Doctor's Guide, 6/11/03 -
"Clearly physicians need to be more aggressive in
putting patients with high cholesterol on lipid-lowering agents, and there
needs to be more vigilance by physicians in monitoring compliance and
effectiveness ... A great portion of these patients were never adequately
monitored with lab tests, so [physicians] can't possibly know if the therapy
is…effective if they don't order lipid-monitoring tests"
Study Compares Extended-Release Lovastatin and Atorvastatin
- Doctor's Guide, 6/10/03
"Eye-Popping" Low-Density Lipoprotein Results from Statin Use Reported
- Doctor's Guide, 6/9/03 - "The percent of patients
achieving LDL goal was highest with atorvastatin and lowest with lovastatin"
- Yeah, but what about
HDL, which some feel is just as important if not more important.
Statin Drugs Linked to Lower Prostate and Renal Cancer Risk
- Doctor's Guide, 6/4/03
Drugs May Prevent Cancer - WebMD, 6/2/03 -
"Overall, taking statins reduces risk of developing
cancer by 20%, but that protection increases to 36% for people who take
statins for four years or more ... But the benefit stops about six months
after the patient stops taking the drug" - Note:
Red yeast rice is a non-prescription statin. See
red yeast rice at Amazon.com.
Simvastatin May Retard Progression of Severe White Matter Changes
- Doctor's Guide, 5/26/03 -
"Simvastatin may slow down the progression of severe
white matter changes in the brain, and may therefore retard
cognitive decline ... The most common type of vascular dementia is due
hardening of the arteries deep inside the brain which causes white
matter changes... and its been shown that this can lead to executive
dysfunction" - Note: Red yeast rice
is a non-prescription statin. See
red yeast rice at Amazon.com.
Previous Treatment with Statins Improves Outcome in Non-Lacunar Ischaemic
Stroke - Doctor's Guide, 5/22/03 -
"Taking statins for any reason seemed to improve the
NLIS as a whole, but especially in patients who had suffered
Simvastatin Therapy Slows Coronary Disease Progression in Patients With and
Without Cardiovascular Risk Factors - Doctor's Guide, 5/22/03 -
therapy versus placebo resulted in decreases in mean coronary artery
diameters ... and minimum diameters ... study results support the contention
that the therapeutic effect of statin lipid lowering drugs on
angiographically seen coronary atherosclerosis is linked to the reduction of
coronary events without regard to the presence of known cardiovascular risk
- Note: Red yeast rice is a non-prescription
red yeast rice at Amazon.com.
Statins Better than Antioxidants in Lowering Cholesterol in High Risk
Conditions - Doctor's Guide, 5/22/03
Ezetimibe-Statin Combination Lowers Cholesterol Safely and Effectively in
the Elderly - Doctor's Guide, 5/17/03
Statin Use Tied to Lower Risk for Choroidal Neovascularization with Macular
Degeneration - Doctor's Guide, 5/7/03
Simvastatin Enhances Bone Formation And Augments Bone Mineral Density
- Doctor's Guide, 4/24/03 - "After a year's
treatment with simvastatin the increases in
bone mineral density at the lumbar spine, femoral neck and femur were
2.8, 1.0 and 0.8% respectively. In contrast, lumbar spine, femoral neck and
femur bone mineral density declined by 1.6, 1.4, and 1.2% in the control
Niacin Extended-Release/ Lovastatin Combination Effective in Patients with
Multiple Lipid Disorders - Doctor's Guide, 4/23/03 -
niacin ER/lovastatin was found to be more
effective than each of its components, showing improved levels of
low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein
cholesterol (HDL-C) and triglycerides (TG)" - Note: Niacin usually
increases HDL (the good cholesterol) much more than statins. From my own
experience and from taking to others, it seems like many physician's may
ignore low HDL.
Disease: Statins May Be a New Treatment
- WebMD, 4/21/03
- Drug Combo
Improves Cholesterol Levels - WebMD, 4/11/03
Drugs: Breast Cancer Treatment? - WebMD, 4/10/03 -
"One reason cancer cells grow so fast is that they lack biochemical brakes
that slow cell growth ... Mevacor -- and, likely, other statins -- lets
these growth-brakes build up inside cancer cells -- making them a
breast cancer treatment down the road"
Rosuvastatin Improves Metabolic Syndrome Risk Factors
- Doctor's Guide, 4/9/03
Taking Statins After Acute Ischemic Stroke Improves Outcome
- Doctor's Guide, 4/8/03
Niacin Extended-Release Lovastatin Effective In Lowering Cholesterol
- Doctor's Guide, 4/7/03
Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High
Cholesterol - Doctor's Guide, 4/4/03 -
is considered an emerging risk factor and risk marker for coronary heart
disease ... the levels of C-reactive protein were about halved when the
ezetimibe plus simvastatin results were compared with simvastatin alone.
The combination produced about a 34.8% reduction compared to an 18.2%
reduction if the statin was used as monotherapy"
Atorvastatin Addition to High Blood Pressure Treatment Reduces Heart Events
- Doctor's Guide, 4/3/03
- Statin Appears
Promising for MS - Medscape, 4/2/03
Statins Have Dramatic Effect On Hypertensives With Normal Cholesterol
- Doctor's Guide, 4/2/03
- Zocor for
Multiple Sclerosis Treatment - WebMD, 4/2/03
- Statins Have
Heart Benefits in Patients With Normal Cholesterol Levels
- WebMD, 4/2/03
Statins Appear To Have Favourable Impact On Psychological Conditions
- Doctor's Guide, 4/2/03 - "the longer people are on
the statins the more their symptoms of
depression, anxiety and hostility decrease
... When people stop taking statins or can not tolerate the medicine, their
depression, anxiety and hostility returns to pre-statin levels"
Rosuvastatin Achieves LDL-C Goal When Other Statins Fall Short
- Doctor's Guide, 4/1/03
Statin Treatment Lowers Risk Level Of Patients With Multi-Vessel Disease
- Doctor's Guide, 3/31/03
Pravastatin Plays Significant Role in Preventing Progression of Coronary
Atherosclerosis - Doctor's Guide, 3/28/03
Prevention: Statin Drugs Show Most Effect - WebMD, 3/24/03
Statin Studies Show Mixed Results - Psychiatry News, 3/21/03
Ezetimibe Plus Lovastatin Offers New Treatment Option For
Hypercholesterolemia - Doctor's Guide, 2/20/03
Statins Improve Leg Functioning, Peripheral Arterial Disease Or Not
- Doctor's Guide, 2/20/03
Statins May Have Different Effects on Platelet Function
- Doctor's Guide, 1/30/03
Statins/Beta Blockers Impact On Certain C-Reactive Protein Levels
- Doctor's Guide, 1/29/03 - "Some 93% of the 89
patients who did not use
beta-blockers and were in
the highest CRP category and had
ischaemia, compared with 42% among
patients in the lower four categories. Similarly, 94% of the 67 patients who
did not use
statins and were in the highest CRP category had
exercise-induced ischaemia, compared with 44% in the lower four categories"
Statin Therapy Does Not Slow Cognitive Decline - Clinical Psychiatry
News, 1/03 - "pravastatin showed no effect at all on
cognition in PROSPER. Similarly, simvastatin exerted no impact upon
cognitive decline in the earlier 20,536-patient randomized double-blind
Heart Protection Study ... It might be better to look at the use of
in the elderly to prevent cognitive decline”
based upon accumulating extremely promising clinical trials data on that
score ... Prior statin trials in middle-aged patients have shown stroke
prevention but not until after 5-6 years of treatment"
Ezetimibe Plus Simvastatin Safely Improves Lipid Profile
- Doctor's Guide, 1/17/03 -
"Ezetimibe and simvastatin given together reduced
cholesterol by 44 to 57%, reduced
triglycerides by 20 to 28% and raised high-density
lipoprotein cholesterol by 8 to 11%, depending on the simvastatin dose"
- Ezetimibe is a
inhibitor, simvastatin is a statin.
- Bad Boy in the
Blood: CRP - WebMD, 1/15/03 -
"CRP doesn't just
mark risk. It contributes to plaque formation in the blood-vessel wall. It
promotes cholesterol uptake ... The most dazzling observation has been that
in postmenopausal women, even those with low cholesterol levels, CRP
identifies a three-fold increased risk for
coronary artery disease ... When they added CRP to these cells, they saw
dramatic effects. The cells began to secrete a substance called PAI-1.
Increased PAI-1 secretion predicts formation of blood clots and heart
disease. It also predicts diabetes and the pre-diabetes condition known as
metabolic disorder ... You can lower your CRP levels by doing the same
things you would do to lower your cholesterol levels: lose weight, eat fewer
calories and a very low fat diet, take the cholesterol-lowering drugs known
as statins, and the natural form of vitamin E"
Heart-Smart Program Pays Off - WebMD, 1/14/03 -
"The healthy benefits of a low-fat diet,
exercise, and cholesterol-lowering statin drugs
may be much greater in combination than alone in helping people with heart
disease prevent future heart attack,
stroke, and even death. New research shows following a strict program
that combines all three approaches can lower a person's chances of suffering
a major heart-related problem from one in three to one in 15"
Hypercholesterolaemic Children Benefit From Early Statin Therapy
- Doctor's Guide, 1/9/03
Atorvastatin, Simvastatin Effects Similar For Subclinical Atherosclerosis
- Doctor's Guide, 1/7/03
Anti-Cholesterol Statins Do Not Reduce Reproductive Hormones in Women of
Child-Bearing Age - Doctor's Guide, 12/31/02
Pravastatin Reduces Left Ventricular Mass Independently of Lipid Lowering
Effect - Doctor's Guide, 12/30/02
Statin-Niacin Combination Counters Dyslipidaemic Cardiovascular Risk
- Doctor's Guide, 12/20/02 -
"Combined statin-niacin is a safe, tolerated therapy
that lowers low density lipoprotein cholesterol and raises
high density lipoprotein cholesterol ... At
niacin doses of at least 1000 (mean 1480) mg/day added to a constant
statin regimen in 29 patients, high density lipoprotein cholesterol rose
significantly (by 20 percent)"
Results in Hypertensives with Elevated Cholesterol Similar with Pravastatin,
Usual Care - Doctor's Guide, 12/18/02
Statins Use Poor in Patients Requiring Cholesterol Management
- Doctor's Guide, 12/12/02
- Statins Raise
Heart Transplant Survival - WebMD, 12/9/02
Statins Favourably Affect Heat Release from Atherosclerotic Plaques
- Doctor's Guide, 11/25/02
- Statins Effective
in Elderly, Too - WebMD, 11/18/02 - "Pravachol,
a statin, is an equal-opportunity drug: The elderly get the same benefit as
younger people ... patients who took 40 mg of Pravachol every day had a 20%
reduction in heart disease death and non-fatal heart attacks. A reduction in
strokes was not seen in this study ... There were, however, two downsides to
the study: Patients taking Pravachol were more likely to develop new cancers
during the study than patients taking dummy pills, and Pravachol didn't
protect against memory and thinking problems associated with aging"
More Evidence That Statins Cut Alzheimer's Risk - Clinical Psychiatry
Statins May Increase Survival In Interstitial Pneumonitis
- Doctor's Guide, 11/7/02
- Atorvastatin Every
Other Day as Effective as Daily Dose in Lowering Cholesterol - Medscape,
"At 12 weeks, LDL-C levels decreased by 35% in the
alternate-day and by 38% in the daily group"
Atorvastatin Shown to Decrease Heart Disease and Stroke in Patients with
Hypertension And Low Cholesterol - Doctor's Guide, 10/11/02
- Statins May Help
MS Patients - WebMD, 10/7/02
Researchers Halt Successful Study On Cholesterol, Blood Pressure
- Intelihealth, 10/11/02 -
"Researchers in the Anglo-Scandinavian Cardiac
Outcomes trial were giving the cholesterol-lowering drug atorvastatin to
patients who have normal or low levels of
cholesterol but are at a risk of a
heart attack or
stroke because they have high blood pressure
or other risk factors ... patients taking the prescription drug had
significantly fewer strokes and heart attacks than those taking a placebo"
Hearing Study Reveals Surprises - Intelihealth, 10/6/02 -
"If preventing heart disease also saves hearing, it might offer another
reason to take cholesterol-lowering drugs called
Cholesterol-Lowering Drugs Safe And Effective In Children
- Doctor's Guide, 10/1/02
- Statins Can
Reverse Plaque Buildup - WebMD, 9/23/02 -
"Statin drugs can do more than just lower your LDL
"bad" cholesterol. In high enough doses, they may be able to reverse the
accumulation of artery-clogging plaques that lead to heart attack and
FDA Looking for Grapefruit Interactions - Doctor's Guide, 9/23/02 -
"If a drug has a large first pass effect, consuming grapefruit could cause a
higher drug dose to enter the bloodstream through any of these actions ...
Two drugs Dr. Piazza-Hepp cited as coming recently under suspicion are
calcium channel blocker, and atorvastatin"
- See the
cytochrome P450 system - Ben
Blood Test Doesn't Catch All Statin-Caused Muscle Problems
- Intelihealth, 9/20/02 -
"They have few serious side effects - many
cardiologists tout them as being safer than aspirin. But they can cause rare
cases of muscle destruction, some fatal ... a less severe form of
statin-caused muscle toxicity weakens muscle without damaging the membranes
that release CK into blood ... doctors should not dismiss statin users who
have muscle pain despite a normal CK test"
- Rare Muscle
Problem Linked to Statin Use - WebMD, 9/20/02
Simvastatin Increases HDL and Apo-A1 Better Than Atorvastatin
- Doctor's Guide, 9/13/02
Early Simvastatin Therapy Improves Endothelial Function
- Doctor's Guide, 9/13/02
Simvastatin Protects against Endothelial Dysfunction in Type 2 Diabetes
- Doctor's Guide, 9/5/02
Simvastatin Improves Cholesterol Profile more than Atorvastatin in the
Metabolic Syndrome - Doctor's Guide, 9/4/02
Cholesterol drug cited in nerve study - USA Today, 8/21/02 -
"The drugs, called statins, raise a person's risk of nerve damage by nearly
15%, or roughly one case for every 2,200 patients age 50 or older"
Statin side effect rare, but be aware - USA Today, 8/18/02
- Statins Benefit
Patients at Risk for Coronary Disease, Even When Cholesterol Levels Are
Normal - Medscape, 7/30/02 -
"20,536 British patients (75% male; age range, 40 to
80) with total cholesterol levels of at least 135 mg/dL (3.5 mmol/L) were
randomized to receive simvastatin (40 mg daily) or placebo for 5 years ...
Five-year all-cause mortality was significantly lower in the simvastatin
group than in the placebo group (12.9% vs. 14.7%) -- a difference
attributable mainly to a significantly lower coronary death rate"
Pravastatin Therapy May Help Protect Kidney Function In Patients With
Well-Controlled Hypertension - Doctor's Guide, 7/25/02
Mayo Clinic Study Finds No Statistically Significant Benefit for Statins in
Reducing Risk of Alzheimer's Disease - Doctor's Guide, 7/24/02
Statin Use Associated with 39 percent Reduction in Risk of Alzheimer's
Disease - Doctor's Guide, 7/23/02
Relation of Statin Use and Bone Loss: A Prospective Population-Based Cohort
Study in Early Postmenopausal Women - Doctor's Guide, 7/15/02
- Alternatives to
HRT - WebMD, 7/10/02 -
"A powerful class of drugs called statins reduce the
amount of cholesterol in the blood -- especially LDL, the so-called "bad"
cholesterol. Statins have also been found to reduce
stroke, may reduce osteoporosis, could be an adjunct treatment for
Cholesterol drugs may work on brain - USA Today, 7/9/02 -
"too much cholesterol in the blood can clog arteries in a process that can
lead to a heart attack. But many researchers now think that high blood
cholesterol also affects the brain ... Excess cholesterol may be
instrumental in the formation of senile plaque ... That plaque, the hallmark
Alzheimer's, is an abnormal cluster of dead or dying brain cells and
toxic proteins that short-circuit memory and other crucial brain functions
... People taking statins reduced their risk of
developing Alzheimer's by nearly 80%"
- Wider Guidelines
Urged for Statins - WebMD, 7/5/02 - "Researchers
say prescribing statins to a wider range of people could reduce heart attack
and stroke rates by at least a third ... The clear message from this study
is: 'Treat risk -- not cholesterol level,' ... These findings should tear up
the rule book on statin prescribing"
Zocor (Simvastatin) Saves Lives In High-Risk Patients, Regardless Of
Cholesterol Level, Study In Lancet Shows - Diabetics, Women, Elderly Benefit
In Largest Cholesterol Study Ever - Doctor's Guide, 7/5/02 -
"simvastatin given daily at 40 mg reduced the risk of
heart attack and stroke by about one-fourth
over the treatment period, which averaged 5.3 years ... When adjusted for
non-compliance (inadvertent or deliberate failure to take medication) in the
trial, investigators estimate that the risk reduction among this broad
population is one-third ... Not only did we find that cholesterol-lowering
treatment can protect a far wider range of people than was previously
thought, but that the therapy we used in the study can prevent stroke as
well as heart attack, in patients at risk of CHD even in people with already
moderate or low cholesterol levels ... Patients with average or low
cholesterol levels also achieved CHD risk reductions of about a quarter.
When adjusted for non-compliance, Oxford researchers estimate that the risk
of heart attack and stroke in this group would be reduced by one-third"
Statins Protection Much Wider Than Thought - Doctor's Guide, 7/4/02
Dutch Study Bolsters Evidence That Statins Help After Angioplasty
- Intelihealth, 6/26/02
Statins May Decrease Alzheimer's Risk by 79% - Clinical Psychiatry News,
Vasoreactivity In Type 2 Diabetes Does Not Improve With Atorvastatin Therapy
- Doctor's Guide, 5/21/02
- Cholesterol Drugs
Have Painful Problem - WebMD, 5/13/02
Low-Dose Atorvastatin Safe and Effective in Children
- Doctor's Guide, 5/7/02
Eight Year Follow-Up Shows Safety/Efficacy of Cholesterol-Lowering
Pravastatin - Doctor's Guide, 4/22/02
Cholesterol-lowering drugs may avert Alzheimer's - USA Today, 4/18/02
Statins May Help Prevent Alzheimer's Disease - Doctor's Guide, 4/16/02
- New Test Predicts
Sudden Death Risk - WebMD, 4/15/02 - "those who
suffered sudden cardiac death had higher levels of a substance called
C-reactive protein (CRP) ... CRP is released when blood vessels are inflamed
... the findings of this study show that the levels of CRP in the blood are
even more telling than once thought ... we can intervene with lifestyle
counseling and drugs like statins and aspirin"
- Statin Drugs May
Fight Alzheimer's, Too - WebMD, 4/9/02 - "Statins
block the vasoconstrictive [blood-vessel narrowing] effect of the A-beta
protein -- a critical protein involved in
Alzheimer's disease ... These drugs appear to have
anti-inflammatory properties, independent of their benefit in lowering
cholesterol, that may help protect against dementia" - Note:
Red yeast rice is a non-prescription statin.
Combining Statin With Estrogen May Maximise Post-Menopausal Cardiovascular
Benefits - Doctor's Guide, 4/5/02 -
estrogen alone increased the median level of
C-reactive protein from 0.27 to 0.46 mg/dL, equivalent to a 70 percent
rise. On the other hand, simvastatin decreased C-reactive protein levels
from 0.29 to 0.28 mg/dL. Oral estrogen combined with simvastatin increased
C-reactive protein levels by 29 percent from 0.28 to 0.36 mg/dL" -
Note: Red yeast rice is a non-prescription
Statins May Inhibit Calcium Growth on Aortic Valve in Elderly
- Doctor's Guide, 3/29/02 -
"People who take statins may have at least 60
percent less aortic valve calcium than people who do not take statins"
Lipitor (Atorvastatin Calcium) Reduces C-Reactive Protein In Acute Coronary
Syndrome - Doctor's Guide, 3/19/02
Risk of Fracture Reduced in Women Using Statins - Doctor's Guide,
3/19/02 - "Fracture risk is reduced by 60 percent in
women using 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
(statins) ... This substantial risk reduction is greater than might be
anticipated from increases in bone mineral density (BMD) alone"
- Statins May
Preserve Brain Power - WebMD, 3/18/02 - "The
study also found that statin use was associated with a lower risk of memory
problems or dementia, regardless of total cholesterol level. The authors say
more research is needed to understand exactly how statins seem to protect
the brain, but they suspect that the drugs may work by improving muscle
function and reducing inflammation"
Statin Use, Bone Mineral Density, and Fracture Risk: Geelong Osteoporosis
Study - Archives of Internal Medicine, 3/11/02 -
"The substantial 60% reduction in fracture risk
associated with statin use is greater than would be expected from increases
in BMD alone"
Stopping Statins May Cause Rebound that Triples Risk of Death
- Doctor's Guide, 3/5/02
- Stopping Statins
Can Be Deadly - WebMD, 3/4/02 -
"the study adds evidence that statins may do more
than just lower cholesterol, and that the drugs may protect the heart in
other important ways ... recent research has shown that statins can reduce
harmful inflammation in the arteries that can lead to blood clots ... also
supports the idea that statins increase the release of protective nitric
oxide in the inner walls of the heart. Animal research has shown that when
the statins are suddenly withdrawn, a rebound effect occurs, and the nitric
oxide levels drop below normal -- increasing the risk of heart attack or
other cardiac events"
Lipid-Lowering Agents Cut Dementia Risk With No Indication Bias
- Doctor's Guide, 2/22/02
Beta-Blockade Adds Value For Hypercholesterolemics On Statins
- Doctor's Guide, 2/15/02
Pravastatin Mortality Benefit In Patients With And Without Heart Disease
- Doctor's Guide, 2/14/02
Rosuvastatin More Effective Than Atorvastatin In Hypercholesterolemic
Patients - Doctor's Guide, 2/13/02
FDA Approves Pravachol (Pravastatin) 80 mg for Heart Disease
- Doctor's Guide, 2/11/02
- Diet, Cholesterol
Drug Combo Works Best - WebMD, 2/5/02 - "Drugs
usually can lower cholesterol more than a healthy diet. But combining the
two gives you the best effect ... the drug [Zocor] had some potentially
harmful effects on antioxidant levels. Antioxidants help get rid of toxic
chemicals produced in the body that may increase the risk of heart disease
and even cancer. Zocor decreased levels of the antioxidants vitamin E,
beta-carotene and ubiquinol-10 ... When the drug was taken alone, there also
was another concerning finding. It increased insulin levels and raised
insulin resistance ... The diet did not increase insulin levels or insulin
resistance. In fact, it lowered both of them. This suggests that the diet
may help prevent diabetes. Plus, the Mediterranean diet helped keep insulin
levels and insulin resistance normal in men taking Zocor"
(Fluvastatin) Maintains Favorable Efficacy/Safety Profile in Lipid
Management - Doctor's Guide, 1/18/02
- WelChol (Colesevelam)
Combination With Lipitor (atorvastatin) Cuts Cholesterol Levels
Significantly - Doctor's Guide, 12/27/01
- Diabetic Patients on
Statins Experience Fewer Lower Extremity Infections
- Doctor's Guide, 12/19/01
- Statin Treatment In
Coronary Heart Disease Lowers Levels Of Marker C-Reactive Protein -
Doctor's Guide, 11/29/01
Cholesterol-Lowering Drugs Help - Intelihealth, 11/14/01
- Cholesterol Drugs
Also May Work for Alzheimer's - WebMD, 11/13/01
- Treatment With Simvastatin
Results In Artery Plaque Stabilization
- Doctor's Guide, 11/12/01
- Welchol (Colesevelam)
Effective in Reducing Low Density Lipoprotein Cholesterol
- Doctor's Guide, 10/22/01
- Hormone Therapy
May Increase Risk of Gallstones - WebMD, 10/1/01 -
"women taking statins -- the most popular type of
cholesterol-lowering drug -- had a 45% drop in the chance they would need
- Combined Analysis
Underscores Safety, Efficacy of Lescol (Fluvastatin)/Lescol XL For
Cholesterol Reduction - Doctor's Guide, 9/10/01
Study Backs Cholesterol Drug Safety - Intelihealth, 9/4/01
- International Lipid
Information Bureau Stands Behind Statin Safety
- Doctor's Guide, 9/4/01
- Crestor (Rosuvastatin)
Superior Impact On Lipid Levels Confirmed
- Doctor's Guide, 9/3/01
- American College of
Cardiology/Heart Association Reassure Statins Safe, Effective
- Doctor's Guide, 8/30/01
Cholesterol-lowering drugs' safety defended - USA Today, 8/30/01
Cholesterol Drug Warnings Urged - Intelihealth, 8/21/01 -
"For most of the 8 million Americans taking a statin other than Baycol, the
benefits still outweigh the risks"
Group wants warning on cholesterol drugs - CNN, 8/10/01 -
"Washington D.C.-based Public Citizen says the class
of drugs known as statins are responsible for an additional 50 deaths in the
United States and should carry a more significant warning label ... Statins
work by blocking a liver enzyme that causes cholesterol. In very rare
instances it has been linked to a disease called Rhabdomyolysis, a
potentially life threatening disease in which muscle cells are destroyed and
released into the blood stream. In the worst-case scenario it causes
patients to develop kidney failure."
Cholesterol-Lowering Drug Baycol Pulled Off the Market
- WebMD, 8/8/01
- Baycol (Cerivastatin) Not
To Be Used In Combination With Gemfibrozil, Says Bayer
- Doctor's Guide, 7/25/01 - "Statins are known to
cause a rare side effect of muscle breakdown ... In a very small percentage
of patients, there is a risk of muscle breakdown resulting in kidney damage,
which in rare instances can lead to life-threatening kidney failure ... The
risk of muscle breakdown is greater in patients taking gemfibrozil as well
as other fibric acid derivatives (a group of cholesterol-lowering drugs),
cyclosporine (an immunosuppressant), erythromycin (an antibiotic), azole
antifungals, or lipid-lowering doses of niacin (nicotinic acid) together
with statins including cerivastatin."
Cholesterol drug has wider benefit - USA Today, 6/28/01 - [in addition
to lowering cholesterol] "Cholesterol-lowering
drugs, called statins, apparently work by reducing levels of a chemical
known as C-reactive protein. This protein causes inflammation, promotes
blood clotting and weakens fat-encased blockages inside arteries, causing
them to burst"
- Blood Test Could
Save More From Heart Attacks - WebMD, 6/27/01
Blood Test Could Indicate Who Might Benefit From Cholesterol-Lowering Drugs
- Intelihealth, 6/27/01 -
"Half of all heart attack patients have normal
cholesterol levels. A blood test can detect high levels of C-reactive
protein - a sign of inflammation ... Statins block an enzyme needed to make
cholesterol in the liver. They also reduce levels of C-reactive protein"
- Lipitor (Atorvastatin)
Lowers Levels of LDL-Cholesterol in Women
- Doctor's Guide, 6/21/01
- Statins May Be Effective
For Controlling Blood Pressure - Doctor's Guide, 6/21/01 -
"statin treatment caused a significant (p<0.05) lowering of ambulatory
systolic blood pressure (SBP) on the 24-hour (-4 mm Hg), daytime (-5 mm Hg),
and nighttime (-3 mm Hg) measurements compared to baseline"
- Popular Drugs
Called Statins Not Just for Cholesterol Anymore
- WebMD, 6/14/01 - "may prevent yet another life
threatening condition: deep vein thrombosis, or DVT"
- Pravastatin Improves Graft
And Patient Survival In Kidney Transplant
- Doctor's Guide, 5/28/01
Atorvastatin Lowers C-Reactive Protein In Mixed And Diabetic Dyslipidemia
- Doctor's Guide, 5/21/01
- WelChol (colesevelam
HCl)/Zocor (simvastatin) Combo Better Than Zocor Alone - Doctor's Guide,
4/30/01 - "Treatment with WelChol (3.8 grams daily)
decreased LDL-cholesterol levels by 16 percent, and Zocor (10 milligrams
daily) reduced mean LDL-cholesterol levels by 26 percent; the combination
appeared to be additive, with a 42 percent reduction"
Cholesterol drug may prevent Alzheimer's - CNN, 5/1/01 -
"What we found was that patients taking statins have
a 60 to 70 percent reduction in the risk of Alzheimer's disease"
Hit 'em Hard and Fast: Statins Early After Heart Attack Improve Outcomes,
Save Lives, Cholesterol-Lowering Drugs Work Even if Cholesterol Is Normal
- WebMD, 4/3/01 - "When given to patients with mild
heart attacks, the powerful cholesterol-lowering pill Lipitor not only
lowered their risk of dying from their disease, but also significantly
reduced the risk of future heart attacks and strokes"
New Drug [rosuvastatin] Takes a Sledgehammer to High Cholesterol -
Heart Attack Patients Should Start Statin Drugs Before Leaving Hospital
- WebMD, 1/23/01
Quick drug use improves heart-attack survival - USA Today, 1/23/01
Quick Drug Use Improves Heart Attack Survival Chances - Intelihealth,
1/23/01 - "In the study of 19,599 patients, those
given statins at or before their release from the hospital were about 25
percent less likely to die within a year than those who did not receive the
One Tiny Pill Takes on Heart Attack, Stroke, and Diabetes, Are Statins the
Little Drugs That Can? - WebMD, 1/22/01
- Lipitor (Atorvastatin)
Reduces Angina Recurrence, Urgent Re-admissions In Hospital In-patients
- Doctor's Guide, 11/16/00
Taking Statins Earlier May Reduce Risk of Heart Attack and Death -
- Statin Plus Niacin Reduces
Heart Attack Risk, Reverses Arterial Build-up
- Doctor's Guide, 11/13/01
Inflammation appears to do a number on human heart - CNN, 11/13/00 -
"For now, though, doctors at Mount Sinai Medical
Center said they were fairly certain that one cause of inflammation is high
cholesterol -- and that cholesterol-fighting drugs called 'statins' tend to
- Patients Taking Baycol
(Cerivastatin) Reach Target Cholesterol Levels - Doctor's Guide, 11/2/00
- Study Refutes Relationship
Between Statins And Bone Mineral Density
- Doctor's Guide, 9/25/00
Cholesterol-Lowering Drugs May Boost Blood Vessel Growth - WebMD,
- Pravastatin Therapy
Decreases the Risk of Stroke - Medscape, 8/3/00
Statins Linked To Lower Fracture Risk In Older Patients
- Doctor's Guide, 6/27/00
Cholesterol-Lowering Drug May Protect Women From Bone Fractures -
- Lipid Lowering Drugs Seem
to Have Benefits in Hypertension Control
- Doctor's Guide, 5/19/00 - "A combination of
lipid-lowering statins and an anti-hypertensive drug is more effective than
an anti-hypertensive drug alone in reducing blood pressure among high-risk
Atorvastatin Better than Simvastatin for Achieving Total Cholesterol Targets
- Doctor's Guide, 4/12/00
(Niacin/Lovastatin) Reduces Cholesterol, Triglyceride Levels - Doctor's
- Zocor (Simvastatin)
Increases HDL And apo A-I More Than Lipitor (Atorvastatin)
- Doctor's Guide, 3/15/00
Cholesterol-Lowering Drugs Prevent Deaths After Threatened Or Actual Heart
Attack - Doctor's Guide, 3/14/00
Cholesterol-lowering drugs may lead to osteoporosis treatments - CNN,
- Pravastatin Appears To
Reduce Incidence Of Stroke - Doctor's Guide, 11/9/99
Cholesterol-Lowering Drugs Provide Double Protection Against Heart Disease
- Doctor's Guide, 7/12/99
- Aggressive Cholesterol
Lowering With Lipitor Reduces Cardiac Events - Doctor's Guide, 7/8/99
Cholesterol-lowering drugs may work as well as heart surgery - CNN,
- Cholesterol-Lowering Drugs,
Soy Milk And Tomato Extract All Reduce Cancer Risk - Doctor's Guide,
- Study Shows Significant
Difference Between Two Statins In Raising HDL
- Doctor's Guide, 8/25/98
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