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Home > Anti-aging Research > Cytochromes.
Cytochromes
General Information:
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Cytochromes - American Academy of Family Physicians
- Cytochromes - emedicine.com
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Cytochrome - familydoctor.org
- Books on Cytochromes - Amazon.com
News & Research:
- St John's Wort Alters Enzymes Involved in the Metabolism of About 50% of Over-the-Counter and Prescription Medications
- Doctor's Guide, 9/18/03 - "long-term administration of St John's wort may result in diminished clinical effectiveness or increased dosage requirements for all CYP 3A4 substrates, which represent at least half of marketed medications" - The
way I understand it, the enzyme that SJW increases protects the liver. JAMA always seems to be biased against supplements, which might be why they didn't mention that. Have they ever mentioned the pitfalls of prescription drugs?
- St. John's Wort Increases Metabolism Via CYP 3A4 - Medscape, 9/16/03
- What should I know about drug interactions with St. John's wort? - Natural Foods Merchandiser, 4/03 -
"One activity of St. John's wort, probably independent
of its mood-altering actions, is increasing the CYP3A4 enzyme activity of liver and intestinal-wall cells"
- Why should one avoid grapefruit when taking Valium or a cholesterol-reducing medication? - Dr. Weil, 3/28/03
- Cholesterol Metabolism May Provide Alzheimer’s Clue - Psychiatric Times, 3/21/03 -
"The CYP46 enzyme regulates levels of brain cholesterol, researchers believe,
through a feedback mechanism that allows the amount of soluble cholesterol leaving the brain to match closely the amount of cholesterol that is normally synthesized or routinely recycled (through APOE)
within the brain. The end result, under normal conditions, is a fairly constant level of cholesterol in brain tissues"
- Smoking-Related Anti-psychotic Dose Adjustment Could Improve Response - Doctor's Guide, 3/10/03 -
"Clozapine
was largely metabolised by the cytochrome P450 enzyme CYP1A2. Smoking powerfully induced this enzyme's activity"
- FDA Looking for Grapefruit Interactions - Doctor's Guide, 9/23/02 -
"If a drug has a large first pass effect, consuming grapefruit could cause a
higher drug dose to enter the bloodstream through any of these actions ... Two drugs Dr. Piazza-Hepp cited as coming recently under suspicion are amlodipine,
a calcium channel blocker, and atorvastatin"
- St. John's Wort: Effective, with Caveats - Nutrition Science News, Spring, 02 -
"The cytochrome P450 system is a set of enzymes used to break
down many substances in the liver. Scientists have recently found that hyperforin, hypericin, and biapigenin
activate five of the key cytochrome P450 enzymes.10 ... Of the P450 enzymes, CYP3A4 is one of the most important—involved in the breakdown of more than 50 percent of all pharmaceutical drugs currently used.2 Treating human liver cells with hyperforin dramatically increases CYP3A4 activity. Thus, hypericum extracts
are likely to interact with more drugs than expected"
- Hypericum, Drug Interactions, and Liver Effects - Medical Herbalism, Medical Herbalism (2000)11(2):16) -
"The specific enzyme system whose activity
was increased in the test subjects is the CYP3A, part of the p450 microsomal enzyme system, responsible for Phase I detoxification in the liver"
- Characterising Fluvoxamine Metabolism - Doctor's Guide, 4/19/02 -
"the higher fluvoxamine doses inhibited CYP1A2 and
CYP2C19 by approximately 75 to 80 per cent. The inhibition with the lower doses was around 40 to 50 per cent"
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