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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
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Health Conditions > Osteoporosis
Osteoporosis
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-
Effects of
vitamin E on bone turnover markers among US postmenopausal women - J Bone
Miner Res. 2012 Feb 3 - "Increased oxidative stress and
inflammation resulting from aging and declining estrogen levels can lead to
increased bone loss in postmenopausal women. Alpha- and gamma-tocopherol, the
two predominant isomers of vitamin E, have antioxidant and anti-inflammatory
properties, but their effects on bone metabolism have not been well studied in
humans. We examined the associations between dietary and total (diet and
supplements) alpha-tocopherol intake, serum alpha- and gamma-tocopherol levels
and their ratio, and bone turnover markers (BTMs) among postmenopausal women
aged ≥45 years ... serum bone-specific alkaline phosphatase (BAP), a biomarker
of bone formation, and urinary N-telopeptides/creatinine (uNTx/Cr), a biomarker
of bone resorption ... Participants had a mean age of 65.5 ± 0.6 years and over
45% used vitamin E (alpha-tocopherol) supplements in the past month. Vitamin E
supplement users had significantly lower serum gamma-tocopherol, higher serum
alpha-tocopherol levels and higher ratio of serum alpha- to gamma-tocopherol
than nonusers. High serum gamma-tocopherol levels and low ratio of serum alpha-
to gamma-tocopherol were associated with increased BAP levels (P < 0.01 for
both). There were no associations between any of the vitamin E variables and
uNTx/Cr. In conclusion, we hypothesize that gamma-tocopherol may uncouple bone
turnover, resulting in more bone formation than resorption. Vitamin E
supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol
levels and may have negative effects on bone formation. Further research is
needed to investigate the potential anabolic effect of gamma-tocopherol from
food sources on bone" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb
.
-
The multiple nutrient needs of bones: Review - Nutra USA, 10/26/11 -
"According to the new review of the literature, the
majority of studies concerning bone health have shown that “vitamin B complex
and vitamins C, E, and K correlated positively with bone mineral density (BMD)
at multiple skeletal sites and/or were associated with reduced risk of fracture,
independent of BMD” ... Animal data has “confirmed” that vitamin E, and
particularly the tocotrienol form of vitamin E, had anti-osteoporotic activities
... Biological plausibility does exist for vitamin K, since osteocalcin is a
vitamin K-dependent protein and it is essential for the body to use calcium in
bone tissue. Without adequate vitamin K, the osteocalcin remains inactive, and
this not effective" - [Abstract]
-
Pro-bone and
anti-fat effects of green tea and its polyphenol, epigallocatechin in rat
mesenchymal stem cells in vitro - J Agric Food Chem. 2011 Aug 31 -
"In conclusion, this is the first report of dual action
of green tea polyphenol EGC in promoting osteogenesis and inhibiting adipocyte
formation in MSCs. Our results provide scientific evidence to support the
potential use of green tea in supporting the bone against degenerative diseases
such as osteoporosis" - See
Jarrow Green Tea
extract at iHerb
.
-
Protective
Effect of Pycnogenol® on Ovariectomy-induced Bone Loss in Rats - Phytother
Res. 2011 Jun 28 - "The results indicated that orally administered PYC can
decrease the bone turnover rate in OVX rats, resulting in positive effects on
the biomechanical strength of bone and bone mineral density" - See
Pine Bark/Pycnogenol products at iHerb.

-
High serum
25-hydroxyvitamin D is associated with low incidence of stress fractures - J
Bone Miner Res. 2011 Jun 22 - "There was approximately
half the risk of stress fracture in the top compared to bottom quintile of serum
25(OH)D concentration (OR = 0.51, 95% CI 0.34-0.76, p < 0.01). The range of
serum 25(OH)D in the lowest quintile was 1.5-19.7 (Mean 13.9) ng/ml, while in
the highest it was 39.9-112 (Mean 49.7) ng/ml" - See
vitamin D products at iHerb.

-
Serum 25
hydroxyvitamin (OH)D and clinical fracture risk in a multiethnic Cohort of
women: The Women's health initiative (WHI) - J Bone Miner Res. 2011 Jun 27 -
"In multivariable models, higher 25(OH)D levels as
compared with levels <20ng/mL were associated with a lower risk of fracture in
White women: (20- < 30 ng/mL), OR = 0.82; (0.59, 1.16) and (>30.0 ng/mL),
OR = 0.55; (0.34, 0.89), p trend = 0.02. In contrast, higher 25(OH)D (>20 ng/mL)
as compared with levels <20ng/mL were associated with a higher risk of fracture
in Black women, OR = 1.45; (1.06, 1.98), p trend = 0.043. Higher 25(OH)D (>30.0 ng/mL)
was associated with higher fracture risk in Asian women after adjusting for DBP,
OR = 2.78; (0.99, 7.88), (p trend = 0.04). There was no association between
25(OH)D and fracture in Hispanic or American Indian women. Our results suggest
divergent associations between 25(OH)D and fracture by race/ethnicity. The
optimal level of 25(OH)D for skeletal health may differ in White and Black
women"
-
Blueberries help lab rats build strong bones - Science Daily, 6/21/11 -
"animals fed rations that contained 10 percent freeze-dried blueberry powder had
significantly more bone mass than their counterparts whose rations were
blueberry-free ... When the researchers exposed laboratory cultures of
bone-forming cells (osteoblasts) to blood (serum) from the animals, the
scientists found that serum from the blueberry-fed rats was associated with an
increase in development of osteoblasts into mature, functional bone cells" - See
blueberry extracts at iHerb.
-
High
levels of vitamin D needed for bone density drugs to work, study shows -
Science Daily, 6/6/11 - "To fully optimize a drug therapy for osteoporosis and
low bone mineral density (BMD), patients should maintain vitamin D levels above
the limits recently recommended by the Institute of Medicine (IOM) ...
maintaining a circulating vitamin D level above 33 ng/ml is associated with a
seven-fold greater likelihood of having a more favorable outcome with
bisphosphonate therapy" - See
vitamin D products at iHerb.

-
Before you start bone-building meds, try dietary calcium and supplements,
experts urge - Science Daily, 5/2/11 - "For many
people, prescription bone-building medicines should be a last resort ...
adults who increase their intake of calcium and vitamin D usually increase
bone mineral density and reduce the risk for hip fracture significantly ...
I suspect that many doctors reach for their prescription pads because they
believe it's unlikely that people will change their diets ... prescription
bone-building medications are expensive, and many have side effects,
including ironically an increase in hip fractures and jaw necrosis. They
should be used only if diet and supplements don't do the trick ... For bone
health, the researchers also encourage consuming adequate protein, less
sodium, and more magnesium and potassium"
-
Belly fat puts women at risk for osteoporosis, study finds - Science
Daily, 11/30/10
-
High-Protein Diet Limits Bone Resorption - Doctor's Guide, 10/19/10 -
"The clinical takeaway message is that if you are a
postmenopausal woman and dieting, if you can take 24% of your total calories as
protein, and have adequate calcium and vitamin D, you can prevent the bone loss
that is typically associated with weight loss"
-
Resveratrol
prevents RANKL induced osteoclast differentiation of murine osteoclast
progenitor RAW 264.7 cells through inhibition of ROS production - Biochem
Biophys Res Commun. 2010 Sep 16 - "The bone protective effects of resveratrol
have been demonstrated in several osteoporosis models while the underlying
mechanism is largely unclear ... We postulate that the direct inhibitory effects
of resveratrol on osteoclastogenesis are mediated via inhibition of ROS
generation" - See
resveratrol products at iHerb.

-
Science strengthens for olive extract’s bone benefits - Nutra USA, 9/14/10 -
“Our data suggest that oleuropein, highly abundant in olive tree products
included in the traditional Mediterranean diet, could prevent age-related bone
loss and osteoporosis" - [Abstract]
- See
olive Leaf extracts at iHerb.

-
Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on
differentiation in stem cells derived from bone marrow - Osteoporos Int.
2010 May 21 - "Our data suggest that oleuropein, highly abundant in olive tree
products included in the traditional Mediterranean diet, could prevent
age-related bone loss and osteoporosis" - See
olive Leaf extracts at iHerb.

-
Acid diet
(high-meat protein) effects on calcium metabolism and bone health - Curr
Opin Clin Nutr Metab Care. 2010 Aug 16 - "Increased
potential renal acid load resulting from a high protein (intake above the
current Recommended Dietary Allowance of 0.8 g protein/kg body weight) intake
has been closely associated with increased urinary calcium excretion. However,
recent findings do not support the assumption that bone is lost to provide the
extra calcium found in urine. Neither whole body calcium balance is, nor are
bone status indicators, negatively affected by the increased acid load. Contrary
to the supposed detrimental effect of protein, the majority of epidemiological
studies have shown that long-term high-protein intake increases bone mineral
density and reduces bone fracture incidence. The beneficial effects of protein
such as increasing intestinal calcium absorption and circulating IGF-I whereas
lowering serum parathyroid hormone sufficiently offset any negative effects of
the acid load of protein on bone health"
-
T3 affects
expression of collagen I and collagen cross-linking in bone cell cultures -
Biochem Biophys Res Commun. 2010 Aug 10 - "T3 increased mRNA expressions of
procollagen-lysine-1,2-oxoglutarate 5-dioxygenase 2 (Plod2) and of lysyloxidase
(Lox), both genes involved in post-translational modification of collagen.
Moreover, it stimulated mRNA expression of BMP-1, the processing enzyme of the
lysyloxidase-precursor and of procollagen. An increase in the collagen
cross-link-ratio Pyr/deDHLNL indicates, that T3 modulated cross-link maturation
in the MC3T3-E1 culture system. These results demonstrate that T3 directly
regulates collagen synthesis and collagen cross-linking by up-regulating gene
expression of the specific cross-link related enzymes, and underlines the
importance of a well-balanced concentration of thyroid hormones for maintenance
of bone quality" - See
T3 at International Anti-aging Systems.
-
Low
calcium intake linked with increased risk of osteoporosis and hypertension in
postmenopausal women - Science Daily, 6/18/10 - "a
significantly increased proportion of women (35.4%) who consumed a lower amount
of calcium through intake from dairy sources, had a concurrent diagnosis of both
hypertension and osteoporosis, compared with women who consumed a higher amount
of calcium (19.3% p<0.001) ... Further statistical analyses revealed that a
lower calcium intake was associated with an increased risk of developing
hypertension or osteoporosis over time when compared with controls (Odds Ratio
(OR) hypertension: 1.43; 95%CI: 1.12-1.82, osteoporosis: OR 1.46; CI:
1.15-1.85). Women who consumed a lower amount of calcium were shown to be most
likely to develop both conditions over time compared with women consuming a
higher amount of calcium (OR 1.60; CI: 1.09-2.34)"
-
Vitamin D
deficiency and frailty in older Americans - J Intern Med. 2010 Apr 28 -
"Nationally representative survey of noninstitutionalized US residents collected
between 1988 and 1994. Results. 25-Hydroxyvitamin D deficiency, defined as a
serum concentration <15 ng mL(-1), was associated with a 3.7-fold increase in
the odds of frailty amongst whites and a fourfold increase in the odds of
frailty amongst non-whites. This association persisted after sensitivity
analyses adjusting for season of the year and latitude of residence, intended to
reduce misclassification of persons as 25-hydroxyvitamin D deficient or
insufficient. Conclusion. Low serum 25-hydroxyvitamin D concentrations are
associated with frailty amongst older adults" - See
vitamin D products at iHerb.

-
Dietary
protein may reduce hip fractures in the elderly - Science Daily, 5/5/10 -
"individuals who were in the lowest 25 percent of
dietary protein intake had approximately 50 percent more hip fractures than
those who consumed greater amounts of dietary protein (all within normal
intakes). Those who suffered hip fractures consumed less than the 46 grams of
dietary protein per day recommended for adults"
-
NASA
studies find omega-3 may help reduce bone loss - Science Daily, 5/10/10 -
"In a series of cell-based studies, scientists
documented that adding a specific omega-3 fatty acid to cells would inhibit the
activation of factors that lead to bone breakdown. This was true in both typical
cell cultures and those designed to mimic weightlessness. The inhibited factor
is known as "nuclear factor kappa B" or NFκB. NFκB is involved in immune system
behavior and the inflammation process. The activation of NFκB in different
tissues can lead to bone and muscle loss" - See Nutra USA article below.
It was DHA, not EPA that worked. See
Jarrow Max DHA at iHerb.

-
Omega-3 linked to healthier, stronger bones: Rat study - Nutra USA, 5/7/10 -
"According to findings of a new study with rats, DHA “appears to be a vital
constituent of marrow” and enhances bone mineral content (BMC). The findings did
not extend to EPA, however ... Scientists from NASA recently reported in the
Journal of Bone and Mineral Research that the omega-3 EPA may protect against
bone loss during space flight" - [Abstract] - See
Jarrow Max DHA at iHerb.

-
Those
who exercise when young have stronger bones when they grow old - 5/3/10 -
"those who actively did sports, and also those who used
to do sports, had greater bone density than those who had never done sports ...
men who had stopped training more than six years ago still had larger and
thicker bones in the lower leg than those who had never done sport ... The bones
respond best when you're young, and if you train and load them with your own
bodyweight during these years, it has a stimulating effect on their development"
-
Bone
mineral content is positively correlated to n-3 fatty acids in the femur of
growing rats - Br J Nutr. 2010 Apr 27:1-12 - "DHA accumulates in the osteoblast-rich and nerve-abundant periosteum of femur; DHA but not EPA appears
to be a vital constituent of marrow and periosteum of healthy modelling bone;
and both DHA and total n-3 PUFA strongly correlate to BMC" - See
Jarrow Max DHA at iHerb.

-
Beer is
a rich source of silicon and may help prevent osteoporosis - Science Daily,
2/8/10 - "Silicon is present in beer in the soluble form
of orthosilicic acid (OSA), which yields 50% bioavailability, making beer a
major contributor to silicon intake in the Western diet. According to the
National Institutes of Health (NIH), dietary silicon (Si), as soluble OSA, may
be important for the growth and development of bone and connective tissue, and
beer appears to be a major contributor to Si intake. Based on these findings,
some studies suggest moderate beer consumption may help fight osteoporosis, a
disease of the skeletal system characterized by low bone mass and deterioration
of bone tissue" - See
Jarrow BioSil at iHerb
(it says "Reduces Fine Lines and Wrinkles by 19%").
I put ten drops of it in my coffee every morning.
-
Benefits
of calcium and vitamin D in preventing fractures confirmed - Science Daily,
1/14/10 - "both calcium and vitamin D supplements on a
daily basis reduces the risk of bone fractures, regardless of whether a person
is young or old, male or female, or has had fractures in the past, a large study
of nearly 70,000 patients from throughout the United States and Europe has
found" - See
vitamin D products at iHerb
.
-
Vitamin D:
What is an adequate vitamin D level and how much supplementation is necessary?
- Best Pract Res Clin Rheumatol. 2009 Dec;23(6):789-95 -
"Vitamin D modulates fracture risk in two ways: by decreasing falls and
increasing bone density. Two most recent meta-analyses of double-blind
randomised controlled trials came to the conclusion that vitamin D reduces the
risk of falls by 19%, the risk of hip fracture by 18% and the risk of any
non-vertebral fracture by 20%; however, this benefit was dose dependent. Fall
prevention was only observed in a trial of at least 700IU vitamin D per day, and
fracture prevention required a received dose (treatment dose*adherence) of more
than 400IU vitamin D per day. Anti-fall efficacy started with achieved
25-hydroxyvitamin D levels of at least 60nmoll(-1) (24 ngml(-1)) and
anti-fracture efficacy started with achieved 25-hydroxyvitamin D levels of at
least 75nmoll(-1) (30ng ml(-1)) and both endpoints improved further with higher
achieved 25-hydroxyvitamin D levels. Founded on these evidence-based data
derived from the general older population, vitamin D supplementation should be
at least 700-1000IU per day and taken with good adherence to cover the needs for
both fall and fracture prevention. Ideally, the target range for
25-hydroxyvitamin D should be at least 75nmoll(-1), which may need more than
700-1000IU vitamin D in individuals with severe vitamin D deficiency or those
overweight" - See
vitamin D products at iHerb
.
-
New
Evidence That Green Tea May Help Improve Bone Health - Science Daily,
9/16/09 - "The scientists exposed a group of cultured
bone-forming cells (osteoblasts) to three major green tea components —
epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG) —
for several days. They found that one in particular, EGC, boosted the activity
of a key enzyme that promotes bone growth by up to 79 percent. EGC also
significantly boosted levels of bone mineralization in the cells, which
strengthens bones. The scientists also showed that high concentrations of ECG
blocked the activity of a type of cell (osteoclast) that breaks down or weakens
bones. The green tea components did not cause any toxic effects to the bone
cells, they note" - See
Jarrow green tea extract at iHerb
.
-
Higher sea
fish intake is associated with greater bone mass and lower osteoporosis risk in
postmenopausal Chinese women - Osteoporos Int. 2009 Aug 6 -
"After adjusting for the potential confounders, we
observed dose-dependent relations between sea fish intake and BMDs, BMCs, and
osteoporosis risk; the mean BMDs were 3.2-6.8% higher, and BMCs 5.1-9.4% higher
in the top quintile groups (Q5) of sea fish intake than in the bottom quintile
(Q1) at the whole body and hip sites (p < 0.05); the odds ratios (95% confidence
interval (CI)) for osteoporosis (T-score < -2.5) in Q5 were 0.23 (0.08-0.66),
0.12 (0.03-0.59), and 0.06 (0.01-0.44) compared with those in Q1 at the whole
body, total hip, and femur neck, respectively. No independent association
between consumption of freshwater fish or shellfish and bone mass was observed
... Higher intake of sea fish is independently associated with greater bone mass
and lower osteoporosis risk among postmenopausal Chinese women" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Green tea extracts linked to healthier bones: Study - Nutra USA, 8/6/09 -
"EGC was found to stimulate bone mineralisation, while
simultaneously inhibiting the formation of osteoclasts. The other catechins were
found to have a significantly weaker effect ... “The present study illustrated
that the tea catechins, EGC in particular, had positive effects on bone
metabolism through a double process of promoting osteoblastic activity and
inhibiting osteoclast differentiations" - [Abstract]
- See
Jarrow green tea extract at iHerb
.
-
Effects of
Tea Catechins, Epigallocatechin, Gallocatechin, and Gallocatechin Gallate, on
Bone Metabolism - J Agric Food Chem. 2009 Aug 4 -
"The present study illustrated that the tea catechins, EGC in particular, had
positive effects on bone metabolism through a double process of promoting
osteoblastic activity and inhibiting osteoclast differentiations" - See
Jarrow green tea extract at iHerb
.
-
Zinc
Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A
Pilot Study - Ann Nutr Metab. 2009 Jun 9;54(3):218-226 -
"These findings indicate that severe zinc deficiency
initiated during adolescence may have important implications for future bone
health, especially with regards to bone consolidation in the spine"
-
Review supports vitamin K's fracture reducing power - Nutra USA, 5/20/09 -
"The most important findings in this review are that
although supplementation with lower doses of vitamin K may be sufficient to
reduce serum ucOC levels, supplementation with higher doses may be required for
optimal bone health" - [Abstract]
- See
vitamin K products at iHerb
.
-
High-dose vitamin K supplementation reduces fracture incidence in postmenopausal
women: a review of the literature - Nutr Res. 2009 Apr;29(4):221-8 -
"randomized controlled trials (RCTs) ... The review of
the reliable literature confirmed the effect of vitamin K(1) and vitamin K(2)
supplementation on the skeleton of postmenopausal women mediated by mechanisms
other than bone mineral density and bone turnover" - See
vitamin K products at iHerb
.
-
A
Stronger Backbone: DHEA Hormone Replacement Increases Bone Density In Older
Women - Science Daily, 5/17/09 - "Taking a DHEA
supplement combined with vitamin D and calcium can significantly improve spinal
bone density in older women ... The effects of the treatment differed for men
and women. After the first year, women in the test group experienced an
approximate 2 percent increase in bone density, while women in the control group
did not see an increase. After the second year when both groups took the DHEA
supplement, women in the test group experienced an additional 2 percent increase
for a total of approximately 4 percent, while women who switched from placebo to
DHEA also experienced an approximate 2 percent increase ... The same treatment,
however, did not offer similar benefits for older men" - See
DHEA products at iHerb
.
-
Nonvertebral Fracture Prevention With Vitamin D May Be Dose-Dependent -
Medscape, 3/31/09 - "A dose-response relationship
between vitamin D and fracture reduction is supported by epidemiologic data
showing a significant positive trend between serum 25-hydroxyvitamin D
concentrations and hip bone density and lower extremity strength"
-
Vitamin D Supplements Associated With Reduced Fracture Risk in Older Adults
- Doctor's Guide, 3/23/09 - "The authors then pooled the
results of only the 9 trials in which participants received doses of more than
400 international units per day. At this dosage, vitamin D supplements reduced
non-vertebral fractures by 20% and hip fractures by 18% ... A greater reduction
in risk was also seen among trial participants whose blood levels of
25-hydroxyvitamin D achieved a greater increase" - [Science
Daily] - See
vitamin D products at iHerb
.
-
Moderate
Alcohol Intake Associated With Bone Protection - Science Daily, 3/3/09 -
"In an epidemiological study of men and post-menopausal
women primarily over 60 years of age, regular moderate alcohol intake was
associated with greater bone mineral density (BMD). Researchers at the Jean
Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts
University found associations were strongest for beer and wine and, importantly,
BMD was significantly lower in men drinking more than two servings of liquor per
day"
-
Building
Strong Bones: Running May Provide More Benefits Than Resistance Training, Study
Finds - Science Daily, 2/27/09 - "both resistance
training and high-impact endurance activities increase bone mineral density.
However, high-impact sports, like running, appear to have a greater beneficial
effect"
-
Flaxseed
combined with low-dose estrogen therapy preserves bone tissue in ovariectomized
rats - Menopause. 2009 Jan 29 - "Flaxseed + low-dose
estrogen therapy resulted in the highest bone mineral density and peak load at
the lumbar vertebrae, with no effect on bone mineral density or strength in the
tibia and femur. Flaxseed and flaxseed + low-dose estrogen therapy resulted in
significantly higher relative levels of alpha-linolenic acid and
eicosapentaenoic acid and lower levels of linoleic acid, arachidonic acid, and
n-6/n-3 ratio in the lumbar vertebrae and tibia compared with all other groups"
- See
flax seed products at iHerb
.
-
Nutrient
Supports Bone Health Over Time - Science Daily, 1/20/09 -
"The results suggest there is a protective effect of
carotenoids, particularly of lycopene,
against bone loss in older adults. The researchers concluded that carotenoids
may explain, in part, the previously observed protective effects of fruit and
vegetable consumption on bone mineral density" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb
.
-
Genistein Safely Improves Bone Formation in Osteopenic, Postmenopausal Women
- Medscape, 1/14/09 - "Usually, the drugs used in the
management of osteopenia/osteoporosis have been classified as predominantly 'antiresorptive
agents' or as 'bone-forming agents' but, on the basis of our results, genistein
might represent the first therapy that overcomes this classification by
combining a powerful bone-forming as well as an antiresorptive activity ... All
postmenopausal women with bone loss would be ideal candidates for genistein
aglycone treatment ... Genistein aglycone has a good safety profile, and in
addition it is effective against climacteric syndrome (i.e., hot flushes and
night sweats)"
-
Calcium
And Vitamin D May Not Be The Only Protection Against Bone Loss - Science
Daily, 12/3/08 - "Diets that are high in protein and
cereal grains produce an excess of acid in the body which may increase calcium
excretion and weaken bones ... When fruits and vegetables are metabolized they
add bicarbonate, an alkaline compound, to the body ... bicarbonate had a
favorable effect on bone resorption and calcium excretion ... 171 men and women
aged 50 and older were randomized to receive placebo or doses of either:
potassium bicarbonate, sodium bicarbonate, or potassium chloride for three
months. Researchers found that subjects taking bicarbonate had significant
reductions in calcium excretion, signaling a decrease in bone resorption"
-
Tea
Drinking May Help Preserve Hip Structure in Elderly Women - Medscape,
10/29/08 - "The cross-sectional analysis revealed that
mean total hip aBMD was 2.8% greater in tea drinkers ... Compared with non–tea
drinkers, tea drinkers had a significantly higher aBMD at the total hip and
trochanter sites but not at the femoral neck and intertrochanter sites" -
See
Jarrow green tea at iHerb
.
-
Vitamin C linked to Reduced Bone Loss in Older Men - WebMD, 9/19/08 -
"If you don't have enough vitamin C, you don't make
bones right. Collagen is the principal protein of bones, accounting for nearly
half the volume. What the collagen does is prevent bones from coming apart"
- See
vitamin C products at iHerb
.
-
Calcium
With or Without Vitamin D May Help Prevent Osteoporosis - Medscape, 8/27/08
- "For best therapeutic effect, we recommend minimum
doses of 1200 mg of calcium, and 800 IU of vitamin D (for combined calcium plus
vitamin D supplementation)"
-
Vitamin K good for young bones, too: study - Nutra USA, 7/17/08 -
"These findings suggest that improvement in vitamin K
status, and thus in the amount of active osteocalcin, might significantly
improve bone health in children, even in those with arthritis" - See
vitamin K products at iHerb
.
-
Calcium
Alone Does Not Reduce Hip Fracture Risk - Science Daily, 6/29/08 -
"a recent analysis of several studies found no reduction
in risk of hip fracture with calcium supplementation ... Future studies of
fracture prevention should focus on the best combination of calcium plus vitamin
D, rather than on calcium supplementation alone"
-
Choline-stabilized orthosilicic acid supplementation as an adjunct to
Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a
randomized, placebo-controlled trial - BMC Musculoskelet Disord. 2008 Jun
11;9(1):85 - "There were no ch-OSA related adverse
events observed and biochemical safety parameters remained within the normal
range ... Combined therapy of ch-OSA and Ca/Vit D3 had a potential beneficial
effect on bone collagen compared to Ca/Vit D3 alone which suggests that this
treatment is of potential use in osteoporosis" - See
Jarrow BioSil at iHerb
.
I take about 9 drops per day of it with my orange juice.
-
Vitamin
D status and response to treatment in post-menopausal osteoporosis -
Osteoporos Int. 2008 Jun 13 - "The adjusted odds ratio
for incident fractures in vitamin D deficient as compared to vitamin D repleted
women was 1.77 ... Optimal vitamin D repletion seems to be necessary to maximize
the response to anti-resorbers in terms of both BMD changes and anti-fracture
efficacy" - See
Vitamin D products at iHerb
.
-
Current
Vitamin D Recommendations Fraction Of Safe, Perhaps Essential Levels For
Children - Science Daily, 5/27/08 - "The current
recommended daily allowance (RDA) of vitamin D for children is 200 International
Units (IUs), but new research reveals that children may need and can safely take
ten-times that amount ... Only children given the equivalent of 2,000 IUs a day
of vitamin D increased 25-OHD levels from the mid-teens to the mid-thirties (ng/ml)--the
level considered optimal for adults. None of the children in either trial showed
any evidence for vitamin D intoxication" - See
vitamin D products at iHerb
. I've gone to the
2,500 IU on vitamin D .
If you're worried about that being to high, just skip a day or two per week
which most do anyway just by forgetting to take them.
-
Relationship of sex steroid hormones with bone mineral density in a
nationally-representative sample of men - Clin Endocrinol (Oxf). 2008 May 14
- "Men in the lowest quartile of free estradiol had 70%
increased odds (OR=1.69, 95% CI 0.95-2.98) of osteopenia compared with men in
the highest quartile. Men in the lowest quartile of free testosterone had nearly
four times the odds of osteopenia than those in the highest quartile (OR=3.82;
95% CI 1.87-7.78). Lower concentrations of SHBG appeared protective against
osteopenia (p-trend=0.01). Neither total testosterone nor total estradiol was
associated with BMD, although men with clinically low estradiol (<20 ng/l) had
lower BMD (0.930 g/cm(2), 95% CI 0.88-0.98) than men with normal-range estradiol
(1.024 g/cm(2), 1.01-1.04; p=0.004"
-
Aggressive Vitamin D Treatment for Osteoporosis - Medscape, 5/19/08 -
"Singh called the findings "alarming" and said that
although many physicians believe vitamin D deficiency is not a problem, with 41%
of study patients found to have a vitamin D level of less than 30 ng/mL, "most
likely that is not true," he said" - See
vitamin D products at iHerb
.
-
Vitamin D, calcium combo may cut exercise-related stress fractures - Nutra
USA, 4/25/08 - "randomly assigned the recruits to
receive daily supplements of 2,000 mg of calcium and 800 IU of vitamin D, and
the other group received a placebo ... Women receiving the vitamin-mineral
combination were 20 per cent less likely to experience the fractures" - [Abstract]
-
Calcium
and vitamin d supplementation decreases incidence of stress fractures in female
navy recruits - J Bone Miner Res. 2008 May;23(5):741-9 -
"randomized them to 2000 mg calcium and 800 IU vitamin
D/d or placebo ... found a 21% lower incidence of fractures in the supplemented
versus the control group" - [Nutra
USA]
-
Effects of
conjugated linoleic acid and exercise on bone mass in young male Balb/C mice
- Lipids Health Dis. 2006 Mar 23;5:7 - "Conjugated
Linoleic Acid (CLA) has been reported to lower body fat mass. However, weight
loss is generally associated with negative effects on bone mass, but CLA is
reported to have beneficial effects on bone ... a combination therapy of CLA and
EX on bone health has not been studied ... although CLA decreased gain in body
weight by 35%, it however increased bone mass by both reducing bone resorption
and increasing bone formation. EX also decreased gain in body weight by 21% and
increased bone mass; but a combination of CLA and EX, however, did not show any
further increase in bone mass" - See
CLA products at iHerb
.
-
Better Bone Density Test - Dr. Weil, 1/14/08 - "If
you’re a woman at risk for osteoporosis, I strongly recommend that you have a
DEXA scan ... In addition, I recommend that all women supplement with 500 to 700
mg of calcium citrate in two divided doses taken with meals ... For men, I now
suggest aiming for 500 mg from all sources. (Because higher amounts have been
linked to increased risks of prostate cancer, men generally should avoid
supplemental calcium.) I also recommend that both men and women take 1,000 IU of
vitamin D3"
-
Effect
of dehydroepiandrosterone supplementation on bone mineral density, bone markers,
and body composition in older adults: the DAWN trial - Osteoporos Int. 2007
Dec 15 - "Among older healthy adults, daily
administration of 50 mg of DHEA has a modest and selective beneficial effect on
BMD and bone resorption in women, but provides no bone benefit for men"
-
Soy isoflavone intake increases bone mineral density in the spine of menopausal
women: Meta-analysis of randomized controlled trials - Clin Nutr. 2007 Dec 4
- "Isoflavone intervention significantly attenuates bone
loss of the spine in menopausal women. These favorable effects become more
significant when more than 90mg/day of isoflavones are consumed. And soy
isoflavone consumption for 6 months can be enough to exert beneficial effects on
bone in menopausal women"
-
Optimal vitamin d status for the prevention and treatment of osteoporosis -
Drugs Aging. 2007;24(12):1017-29 - "Vitamin D deficiency
[as defined by a serum 25(OH)D level of <50 nmol/L (<20 ng/mL)] is pandemic.
This deficiency is very prevalent in osteoporotic patients. Vitamin D deficiency
causes osteopenia, osteoporosis and osteomalacia, increasing the risk of
fracture. Unlike osteoporosis, which is a painless disease, osteomalacia causes
aching bone pain that is often misdiagnosed as fibromyalgia or chronic pain
syndrome or is simply dismissed as depression. Vitamin D deficiency causes
muscle weakness, increasing the risk of falls and fractures, and should be
aggressively treated with pharmacological doses of vitamin D. Vitamin D
sufficiency can be sustained by sensible sun exposure or ingesting at least
800-1000IU of vitamin D(3) daily" - See
vitamin D products at iHerb
.
-
Tea drinking is associated with benefits on bone density in older women
- Am J Clin Nutr. 2007 Oct;86(4):1243-1247 - "In the
cross-sectional analysis, total hip aBMD was 2.8% greater in tea drinkers
(x: 806; 95% CI: 797, 815 mg/cm(2)) than in non-tea drinkers (784; 764, 803
mg/cm(2)) (P < 0.05). In the prospective analysis over 4 y, tea drinkers
lost an average of 1.6% of their total hip aBMD (-32; -45, -19 mg/cm(2)),
but non-tea drinkers lost 4.0%" - See
Jarrow green tea at iHerb
.
-
Drinking Tea May Slow Bone Loss - WebMD, 10/8/07 -
"A new study shows elderly women who drank tea had
higher bone density in their hips and less bone loss than women who didn't
drink tea ... Previous studies have suggested that phytochemicals in tea,
such as flavonoids, may be responsible for the protective effect against
bone loss due to their estrogen-like properties"
-
New Proof of Genistein's Efficacy and Safety for Osteopenia and Osteoporosis
Published in Annals of Internal Medicine - Doctor's Guide, 7/16/07 -
"85% of the women taking genistein showed a gain in
bone density ... In addition, women taking genistein with calcium and
vitamin D achieved a gain in bone density of approximately 3% per year over
baseline and 6% per year over those taking the placebo"
-
Soy Compound May Bolster Women's Bones - WebMD, 6/18/07 -
"After two years, the DEXA scans showed increases in
bone mineral density in women taking genistein"
-
Two-year randomized controlled trial of vitamin K1 (phylloquinone) and
vitamin D3 plus calcium on the bone health of older women - J Bone Miner
Res. 2007 Apr;22(4):509-19 - "women
who took combined vitamin K and vitamin D plus calcium showed a significant
and sustained increase in both BMD and BMC at the site of the ultradistal
radius"
-
Not just calcium and vitamin d: other nutritional considerations in
osteoporosis - Curr Rheumatol Rep. 2007 Feb;9(1):85-92 -
"Other nutritional considerations
include nutrients such as vitamin B-12 and vitamin K that may reduce
fracture risk by increasing bone mineral density as well as the improvement
of bone microarchitecture. Diets high in fruits and vegetables contribute
nutrients such as magnesium associated with bone health and may also produce
an alkaline environment, reducing calcium excretion and thus improving bone
density"
-
Soy isoflavone intake inhibits bone resorption and stimulates bone formation
in menopausal women: meta-analysis of randomized controlled trials - Eur
J Clin Nutr. 2007 Mar 28 - "Isoflavone intervention significantly inhibits bone resorption and
stimulates bone formation"
-
n-3 Fatty acids are positively associated with peak bone mineral density and
bone accrual in healthy men: the NO2 Study - Am J Clin Nutr. 2007
Mar;85(3):803-7 - "The results
showed that n-3 fatty acids, especially DHA, are positively associated with
bone mineral accrual and, thus, with peak BMD in young men" - See
Mega Twin EPA at
iHerb
or Jarrow Max DHA at
iHerb .
-
Vitamin K(2) supplementation improves hip bone geometry and bone strength
indices in postmenopausal women - Osteoporos Int. 2007 Feb 8 -
"Vitamin K(2) helps maintaining bone
strength at the site of the femoral neck in postmenopausal women by
improving BMC and FNW, whereas it has little effect on DXA-BMD" - See
Vitamin K products at iHerb
.
- Beware
of Bone Boosters? - Dr. Weil, 2/8/07 -
"I also worry about using
bisphosphonates on a long-term basis because of new evidence showing that
they can lead to very serious problems. Dentists have been observing that
some patients on these drugs are at risk of developing an untreatable
condition called osteonecrosis of the jaw (ONJ). Osteonecrosis means death
of bone tissue. ONJ can cause chronic pain and disfigurement. Symptoms
include toothache, jaw pain, loosening of teeth, recurrent infection of the
soft tissue of the jaw, and exposed bone"
-
Vitamin link to bone loss probed - BBC News, 11/14/06 -
"Increased amounts of homocysteine
in the blood may increase the risk of developing osteoporosis ...
Individuals who have a poor dietary intake of B-vitamins tend to have high
homocysteine levels"
-
Potassium citrate supplements linked to thicker bones - Nutra USA,
10/12/06 - "Taking potassium citrate
supplements could boost bone mineral density by similar amounts as observed
with pharmaceuticals ... At the end of the study, women taking the potassium
citrate supplement are reported to have a significant, one per cent increase
in BMD in the vertebrae of the lower back (lumbar spine), compared to
baseline ... However, the bone mineral density of the lumbar spine of women
taking the potassium chloride supplement (none alkaline) was found to have
significantly decreased after one year of supplementation, by about one per
cent" - See
iHerb
or
Vitacost
potassium citrate products.
-
CLA continues to offer possibilities for bone health - Nutra USA,
10/2/06 - "After 10 weeks of either diet, it was
found that the CLA-fed mice had higher bone mineral density (BMD) in
specific bone regions than corn oil (CO)-fed mice. This increased BMD was
tied to a reduced activity of pro-inflammatory cytokines (such as tumor
necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6)) ... the CLA-fed
mice also had significantly lower fat mass and increased muscle mass,
compared to CO-fed mice"
- See CLA products at
iHerb
or
Vitacost .
-
Study Suggests Vitamin K Deficiency as an Osteoporosis Risk Factor -
Doctor's Guide, 9/22/06 - "one of
the early effects of declining estrogen is the impairment of vitamin K
function in bone even before any bone loss that could be attributed to
menopause can be measured ... Our study suggests that the generally accepted
level of vitamin K in healthy women is inadequate to maintain bone health
just at the onset of menopause" - See
iHerb
or
Vitacost
vitamin K products.
- Soy
Isoflavones Protect Postmenopausal Women From Bone Loss - Medscape,
7/14/06 - "There was a significant,
linear dose-related response for isoflavones vs placebo in terms of bone
density at the lumbar spine and femoral neck, but not at the trochanter"
-
Strong support for vitamin K’s bone health benefits - Nutra USA, 6/27/06
- "Supplementation of vitamin K
(MK-4) resulted in reductions in hip fractures of 77 per cent, vertebral
fracture of 60 per cent, and all non-vertebral fractures of 81 per cent"
-
Increasing Dietary and Supplemental Calcium - Medscape, 6/16/06 -
"Postmenopausal women, as reported
in many studies, tend to have average serum 25(OH)D values ranging from 50
to 55 nmol/L (20 to 22 ng/mL)[8,10] and are therefore absorbing the calcium
they ingest with reduced efficiency ... raising serum 25(OH)D from the
typical postmenopausal range up to 75 nmol/L resulted in a 33% reduction in
all osteoporotic fractures combined"
-
Soy isoflavones attenuate bone loss in early postmenopausal Chinese women :
A single-blind randomized, placebo-controlled trial - Eur J Nutr. 2006
Jun 8 - "There is a significantly
dose-dependent effect of soy isoflavones on attenuating bone loss at the
spine and femoral neck possibly via the inhibition of bone resorption in
non-obese postmenopausal Chinese women with high Kuppermann Scale"
-
Evaluating vitamin D status. Implications for preventing and managing
osteoporosis and other chronic diseases - Joint Bone Spine. 2006 Feb 17
- "recent review articles indicate
that current reference ranges for serum 25-OH-vitamin D are too low. An
appropriate lower normal limit may be between 50-100 nmol/l (20-40 ng/ml).
Standard supplement dosages may fail to provide concentrations above this
range" - See
iHerb
or
Vitacost
vitamin D products.
-
Vitamin K treatment for postmenopausal osteoporosis in Indonesia - J
Obstet Gynaecol Res. 2006 Apr;32(2):230-4 -
"After 48 weeks of treatment, the
mean percentage change of lumbar BMD in the vitamin K(2) group was
significantly higher (P < 0.05) than that of the control group" - See
iHerb
or
Vitacost
vitamin K products.
- Women
with Osteoporosis May Need More Vitamin D - Healthwell, 3/16/06 -
"More than half of American women
receiving drug therapy for osteoporosis are deficient in vitamin D ... The
new research suggests that many women with osteoporosis are using drugs to
treat a problem that could be helped simply by getting sun more often or by
taking a nutritional supplement"
-
Bone care: It's still basic - USA Today, 3/5/06 -
"the postmenopausal women in the
study weren't typical. Most who were assigned to take supplements also got
lots of calcium and vitamin D in their diets, so adding pills didn't make
much difference. And many who were assigned placebos also took supplements
on their own, something researchers allowed ... It's not surprising there
was a blunted response ... The National Osteoporosis Foundation saw nothing
in the study to change its endorsement of calcium and vitamin D"
-
Calcium Plus Vitamin-D Supplementation Does An Older Body Good - Science
Daily, 2/24/06 - "The older the
woman, the more likely it is that consistent use of calcium and vitamin-D
supplements will play a role in reducing her risk for osteoporosis"
-
Study Finds Calcium Supplements Don't Prevent Broken Bones - New York
Times, 2/15/06 - "the participants
were randomly assigned to take 1000 milligrams of calcium and 400
international units of vitamin D a day ... When they looked only at the
women who took 80 percent of their pills, the supplements reduced hip
fractures by 29 percent. The annual rate of hip fractures in adherent women
taking the supplements was 10 per 10,000, compared with 14 per 10,000 in
adherent women taking placebos"
-
Calcium, Vitamin
D: Help Women's Hips? - WebMD, 2/15/06 -
"Calcium and vitamin D supplements
may help protect some older women's hips -- but only when taken regularly"
-
Magnesium Prevents Osteoporosis - Healthwell, 2/9/06 -
"a higher magnesium intake was
associated with greater whole-body bone mineral density, after adjusting for
calcium and vitamin D intake, level of exercise, use of estrogen medication,
and other factors known to be related to bone health"
-
Strategies for Preventing Osteoporosis in Men
- Life Extension Magazine, 1/06 -
"For men, maintaining good bone health starts with regular doctor visits to
screen for bone mineral density and prostate cancer. Other essentials are
regular, weight-bearing exercise, healthy, moderate-protein diets, and
supplements including vitamin D, calcium, magnesium, and isoflavones to help
prevent bone mineral losses"
-
Dietary Magnesium Could Lead to Stronger Bones
- Doctor's Guide, 12/21/05 -
"For every 100 milligram per day
increase in magnesium intake, data showed a 1% increase in bone density ... this
link was only true for the older white men and women" - See
iHerb
or
Vitacost
magnesium products.
-
Magnesium could reduce osteoporosis risk - Nutra USA, 12/8/05 -
"Higher Mg intake through diet and
supplements was positively associated with total-body [bone mineral density]
BMD in older white men and women. For every 100 mg per day increase in Mg,
there was an approximate 2 per cent increase in whole-body BMD"
-
Nutritional
Interventions in Osteoporosis - Medscape, 12/1/05 -
"For adults over 50 years of age,
the DASH diet emphasizing fruit and vegetables as well as dairy products and
whole grains and beans, together with a calcium and a vitamin D supplement,
will provide dietary defense against osteoporosis"
-
Silicon may boost calcium/vitamin D bone benefits - Nutra USA, 11/23/05
- "Jarrow Formulas ... The effect
was particularly pronounced in the PINP, the most sensitive bone formation
marker. In the groups receiving six and 12mg of silicon, the improvements
were “significant”" - See
Jarrow BioSil at iHerb
.
-
Leading Osteoporosis Experts Reach Consensus on Role of Vitamin D in Bone
Health in Americans Over 50 - Doctor's Guide, 11/22/05 -
"over 70% of women ages 51-70 and
nearly 90% of women over 70 are not getting the recommended adequate intake
of vitamin D ... The roundtable panelists
expressed concern that current recommendations do not provide for optimal
bone health and recommended that intake levels be increased to 800-1,000 IU
per day for patients over age 50" - See
iHerb
or
Vitacost
vitamin D products.
-
Adequate Vitamin D Status Appears More Important than High Calcium Intake
for Maintaining Calcium Metabolism - Doctor's Guide, 11/8/05 -
"vitamin D sufficiency may be more
important than high calcium intake in maintaining desired values of serum
PTH ... Vitamin D supplements are necessary to ensure adequate vitamin D
status for most of the year in northern climates" - See
iHerb
or
Vitacost
vitamin D products.
-
Most Postmenopausal Women Are Vitamin D Deficient - Doctor's Guide,
9/29/05 - "64% of postmenopausal
women with osteoporosis have a vitamin D deficiency" - See
iHerb
or
Vitacost
vitamin D products.
-
Prevalence of Vitamin D Inadequacy Among Postmenopausal North American Women
Receiving Osteoporosis Therapy - Obstet Gynecol Surv. 2005
Oct;60(10):658-659 - "An adequate
intake of vitamin D and calcium is viewed as a necessary part of treating
osteoporosis ... At a cutoff point of 30 ng/mL, the prevalence of inadequacy
was 63% in women taking less than 400 IU daily and 45% in those taking 400
IU or more" - See
iHerb
or
Vitacost
vitamin D products.
-
Potassium, The Hidden Bone Guardian - betterbones.com, 9/29/05
-
Women
Need More Calcium, Say Experts - WebMD, 9/28/05
-
Postmenopausal Women Falling Far Short of Calcium Goals:
Presented at ASBMR
- Doctor's Guide, 9/28/05 - "A study finds that 85% of postmenopausal women do not
consume enough calcium every day, and on average consume about 500 mg less than
the US government's recommended daily intake (RDA)"
-
Silicon May Play Important Role in Bone Health - Doctor's Guide, 9/27/05
- "Silicon, taken as
choline-stabilized orthosilicic acid (ch-OSA) supplementation, might help
improve bone health and type I collagen synthesis ... the benefits were
especially apparent when evaluating changes in PINP, the most sensitive bone
formation marker, and resulted in significant improvements after 12 months
amongst the subjects in the six and 12 mg silicon groups"
- See
Jarrow BioSil at iHerb
.
-
After Menopause: Eating Soy May Help Bones - WebMD, 9/12/05 -
"Within 10 years of menopause, the
20% who ate the most soy foods reported half as many fractures as the 20%
who ate the least soy ... The highest level of consumption among Chinese
women was about 13 grams of soy protein a day. A cup of soy milk contains
about 6.6 grams"
-
Taking A Break From Fractures: A Closer Look At Vitamin D - Science
Daily, 8/11/05 - "The researchers
concluded, though, that higher daily doses, in the range of 700 to 800 IU,
may reduce the risk of fracture by approximately 25 percent ... only
subjects receiving higher doses of vitamin D supplementation had
significantly fewer fractures than did subjects in the comparison groups"
- See
iHerb
or
Vitacost
vitamin D products.
-
Balance of Essential Fats May Prevent Bone Loss After
Menopause - Doctor's Guide, 7/13/05 -
"After 12 weeks, rats with the lowest ratio of omega-6 to omega-3 fatty acids in
their diet experienced significantly less bone loss than rats in the other
dietary groups ... A 5-to-1 dietary ratio of omega-6 to omega-3 fatty acids led
to a conservation of bone mineral content that we didn't see with a 10-to-1
ratio"
- See Mega Twin EPA at
iHerb
or
Vitacost .
-
Omega-3,
Omega-6 Fatty Acids Can Affect Bone Loss - CBS 2 Chicago, 7/12/05 -
"eating foods rich in omega-3 fatty
acids -- found in walnuts and salmon -- may prevent bone thinning. While
excess amounts of omega-6 -- found in grains and beef -- may actually
promote bone loss ... a low ratio of omega-6 to omega-3 appears to be best"
-
Vitamin D
Deficit: Women's Silent Bone Threat - WebMD, 5/20/05 -
"The study included 1,554
postmenopausal U.S. women being treated for osteoporosis ... More than half
of the women (52%) had less-than-optimal levels of vitamin D ... Doctors
need to pay more attention to vitamin D status"
-
Fracture prevention with vitamin D supplementation: a meta-analysis of
randomized controlled trials - JAMA. 2005 May 11;293(18):2257-64 -
"Oral vitamin D supplementation
between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons.
An oral vitamin D dose of 400 IU/d is not sufficient for fracture
prevention"
-
Homocysteine and vitamin b(12) status relate to bone turnover markers,
broadband ultrasound attenuation, and fractures in healthy elderly people
- J Bone Miner Res. 2005 Jun;20(6):921-9 -
"High Hcy and low vitamin B(12)
concentrations were significantly associated with low BUA, high markers of
bone turnover, and increased fracture risk"
-
Osteoporosis: the role of micronutrients
- Am J Clin Nutr. 2005 May;81(5):1232S-9S - "Calcium has been
shown to have beneficial effects on bone mass at all ages, although the
results are not always consistent. Higher doses than the current US
recommendation (600 IU) of vitamin D in the elderly (age >/= 65 y) may
actually be required for optimal bone health (800-1000 IU/d) ... The other
micronutrient needs for optimizing bone health can be easily met by a
healthy diet that is high in fruits and vegetables to ensure adequate
intakes for magnesium, potassium, vitamin C, vitamin K, and other
potentially important nutrients"
-
Fight Osteoporosis: Bone Up On B12 - Science Daily, 4/23/05 -
"This study suggests adequate
vitamin B12 intake is important for maintaining bone mineral density"
-
Folate and Vitamin B12 Prevent Hip Fracture in Stroke Patients -
Medscape, 3/25/05 - "The magnitude
of benefit is similar to that found in trials of alendronate and raloxifene,
with considerably less potential risk. The fact that BMD did not change
suggests the benefit derives from quality, rather than quantity, of bone"
-
Onions May Fight Osteoporosis - WebMD, 4/8/05
-
Aerobic Exercise, Weights Boost Bone Strength - WebMD, 4/4/05
- Calcium Supplements: Benefits and Risks -
Medscape, 1/26/05 -
"Perhaps the most effective method of preventing osteoporosis is ingestion
of adequate
calcium. Experts suggest the daily requirement
for calcium is 1,300 mg for people ages 9 to 18, 1,000 to 1,200 mg for
adults 19 to 50, and 1,500 mg for people over 50 ... You should take only
the amount of calcium recommended. Ingesting high doses of calcium each day
can be harmful and can cause kidney stones"
- Got Fruit? Bones Need More Than Milk - WebMD,
10/26/04 -
"Most people eat a diet that generates acids ... This increase in acid
levels is thought to reduce bone strength ... Eating foods that buffer the
acidic foods builds strong bones ... Nutrients found in fruits and
vegetables may be protective for bone health ... The teenage girls who ate a
large amount of fruit had the strongest bones"
- Study Says What's Good for the Heart May Be Good for the Bones
- Doctor's Guide, 10/7/04 -
"The study demonstrated a gain of up to 5% in bone mineral density (BMD) at
the hip in postmenopausal women who drank 2 or fewer glasses of wine daily,
and up to 7% in men who drank 1 or 2 beers daily"
- Vitamin K, bone turnover, and bone mass in girls -
Am J Clin Nutr. 2004 Oct;80(4):1075-80 -
"Better vitamin K status was associated with decreased bone turnover in
healthy girls consuming a typical US diet"
- Vitamin D Inadequacy Highly Prevalent Among Women Treated for Osteoporosis
in North America - Doctor's Guide, 10/4/04 -
"More than half of women currently treated for osteoporosis have suboptimal
levels of vitamin D"
- Got Exercise? Workouts Better for Bone Health -
WebMD, 6/11/04
- Vitamins May Lower Osteoporosis Fractures -
Intelihealth, 5/13/04 -
"B vitamins are known to reduce levels of homocysteine ... high levels of
homocysteine at least double the risk of osteoporosis-related fractures"
- High protein promotes bone health - Nutra USA,
4/5/04
- Low
B-12 Levels Linked to Increased Rate of Bone Loss
- Medscape, 3/19/04 - "The results
of this study raise the possibility that supplementation with vitamin B-12
or, for some elderly women, dietary assessment and modification may slow
rates of bone loss" - See
iHerb
or
Vitacost
Vitamin B12 products.
- Vitamin B12 levels linked to bone loss - Nutra
USA, 3/4/04 -
"after adjusting for age, weight and clinic site, women with the lowest
levels of B12 (below 280 pg/ml) experienced significantly more rapid hip
bone loss than women with higher levels of B12"
- Best Ways To Fight Osteoporosis - CBS News,
9/18/03 - "64 percent of women don't
know how much calcium
they need every day ... women from 19- to 50-years-old should consume 1,000
mg; and women over 50-years-old should consume 1,200 mg ... a high calcium
intake will not protect a person against bone loss caused by estrogen
deficiency, physical inactivity, smoking, alcohol abuse or various medical
disorders or treatments" - See
drugstore.com/GNC calcium products
.
- Vitamin D Supplementation and Fracture Prevention
- Medscape, 9/11/03 -
"Bottom line: Vitamin D supplementation is
absolutely critical to bone health in the aging population. Although a
number of research questions still need to be addressed, there is currently
sufficient evidence to show that all women, living in areas of Northern
Latitude, should be taking a vitamin D (and calcium) supplement"
- 60-Minute Workout Stops Bone Loss - WebMD, 9/5/03
-
"Postmenopausal women who work out for 60 minutes, three times a week -- and
take calcium -- can stop bone loss ... calcium alone isn't enough -- you
also need vitamin D"
- Exercise Prevents Bone Loss in Early Post-Menopausal Women
- New Hope Natural Media, 8/14/03
- Vitamin D and Calcium Supplementation Effective for Prevention and Treatment
of Osteoporosis - Doctor's Guide, 7/18/03 -
"Adequate
vitamin D and calcium
intake is essential to the prevention and treatment of osteoporosis. The
Institute of Medicine (IOM) recommends 200 IU/day of vitamin D for women
aged 50 or younger years, 400 IU/day for those aged 51-70 years, and 600
IU/day for those older than 70 years ... In women over the age of 65, there
is increased risk of osteoporotic fracture of the hip and non-vertebral
sites. Daily vitamin D intake between 800 and 900 IU and 1200-1300 mg of
calcium for this population results in increased bone density, decreased
bone turnover, and decreased non-vertebral fractures ... Studies have linked
vitamin D supplementation to a decrease in body sway, suggesting that
vitamin D supplementation may protect against fracture by preventing falls"
- See
drugstore.com/GNC calcium plus vitamin D supplements
.
- Effects on bone mineral density of calcium and vitamin D supplementation in
elderly women with vitamin D deficiency - Joint
Bone Spine. 2003 Jun;70(3):203-208 -
"bone mass in older women with vitamin D deficiency increases significantly
at the lumbar spine, femur, trochanter,
and whole body after calcium and vitamin D supplementation for 1 year, and
concomitantly bone markers improved as vitamin D levels returned to normal"
- Protein intake: effects on bone mineral density and the rate of bone loss in
elderly women - Am J Clin Nutr. 2003
Jun;77(6):1517-25 - "The highest quartile
of protein intake (: 72 g/d) was associated with higher BMD in elderly women
at baseline only when the calcium intake exceeded 408 mg/d"
- Calcium Supplementation and Exercise Improves Bone Mineral Status in
Adolescent Girls - Doctor's Guide, 4/10/03
- Vitamin D Plus Calcium Supplements Boosts Calcium Absorption
- WebMD, 4/1/03 -
"We need calcium for good bones, but
vitamin D is equally important -- it helps the
body with calcium absorption. In fact, calcium supplements plus vitamin D
can increase calcium absorption by up to 65%"
- Vitamin
K Builds Strong Bones - New Hope Natural Media,
3/28/03 - "Without adequate
vitamin K,
osteocalcin cannot be
produced, and bone formation becomes impaired ... when women with
osteoporosis take supplemental vitamin K, the urinary excretion of calcium
falls by about 50%, suggesting that less calcium is being leached from the
bones ... Some research, however, suggests that the optimal level of intake
may be higher, as much as 400 mcg per day. A typical western diet contains
80 to 150 mcg per day" - See
iHerb
or
Vitacost
vitamin K products.
- Remember Sodium? We're Still Getting Too Much -
Intelihealth, 3/14/03 -
"High sodium levels also raise the risk of
osteoporosis and
kidney problems ... In the case of osteoporosis,
potassium appears to offset calcium losses from excessive sodium ...
postmenopausal women with diets high in salt lost higher amounts of bone
mineral. Eating potassium-rich foods such as bananas, tomatoes and orange
juice helped stem the calcium loss"
-
Interaction of Dietary Calcium and Protein in Bone Health in Humans - J.
Nutr. 133:852S-854S, 3/03 - "Protein
has both positive and negative effects on calcium
balance, and the net effect of dietary protein on bone mass and fracture
risk may be dependent on the dietary calcium intake. In addition to
providing substrate for bone matrix, dietary protein stimulates the
production of insulin-like growth factor-1 (IGF-1), a factor that promotes
osteoblast-mediated
bone formation. Protein also increases urinary calcium losses, by several
proposed mechanisms. Increasing calcium intake may offset the negative
impact of dietary protein on urinary calcium losses, allowing the favorable
effect of protein on the IGF-1 axis to dominate"
- Vitamin D Can Prevent Fractures In Older People -
Intelihealth, 2/28/03
- Vitamin D Helps Elderly Avoid Fractures - WebMD,
2/27/03
-
Calcium, vitamin D, milk consumption, and hip fractures: a prospective study
among postmenopausal women - Am J Clin Nutr. 2003 Feb;77(2):504-11 -
"Women consuming 12.5 µg
vitamin D/d from food plus supplements had a 37% lower risk of
hip fracture (RR = 0.63; 95% CI: 0.42, 0.94) than did women consuming <
3.5 µg/d. Total calcium
intake was not associated with hip fracture risk (RR = 0.96; 95% CI: 0.68,
1.34 for 1200 compared with < 600 mg/d). Milk
consumption was also not associated with a lower risk of hip fracture (P for
trend = 0.21)"
-
Vitamin K intake and bone mineral density in women and men - Am J Clin
Nutr. 2003 Feb;77(2):512-6 -
"Low dietary
vitamin K intake was associated with low BMD in
women ... In contrast, there was no association between dietary vitamin K
intake and BMD in men"
-
Walking Your Way to Better Bones - WebMD, 11/13/02
- Low Vitamin D Levels Not Restricted To High-risk Groups
- Doctor's Guide, 9/23/02 - "Vitamin
D insufficiency is far more common than is generally assumed and is not
necessarily restricted to high-risk groups such as the elderly ... Low
vitamin D levels were found across diagnostic categories and were identified
in 88 percent of patients with hip fractures; 67 percent of patients with
wrist fractures; 50 percent of patients with vertebral fractures, and 52
percent of patients with other fractures ... This study demonstrates the
high frequency of
hypovitaminosis
D in a UK specialist bone clinic setting and the clear need for vitamin D
therapy may not [be] appreciated without [taking] vitamin D measurements"
- Low Bone Mineral Density and Quantitative Ultrasound in Men Associated with
Low Vitamin K Status - Doctor's Guide, 9/23/02 -
"Low
vitamin K status is associated with low
quantitative ultrasound (QUS) and low bone mineral density (BMD) of the
femoral neck and trochanter ... What we did was measure the amount of
vitamin K in circulation and use the more sensitive measures of vitamin K
status which was % undercarboxylated osteocalcin ... We corrected for
triglycerides because vitamin K is transported in the blood by
triglyceride-rich lipoproteins ... What we found was that the higher the
amounts of vitamin K in the plasma, the higher the BMD" - So does
that mean that if your triglycerides are in check you may need extra vitamin
K? See
iHerb
and
Vitacost
vitamin K products. - Ben
-
Treating & Preventing Osteoporosis - Life Extension Magazine, 9/02 -
"From systematic research the best external evidence is available for a
supplementation with calcium and
vitamin D and a therapy with the bisphosphonates
alendronate or
risedronate, as well as the selective estrogen receptor modulator
raloxifene (Evista)."
- People Living In Higher Latitudes Require Fall, Winter Vitamin D Supplements
- Doctor's Guide, 6/10/02 - "Given
that almost every person in our sample had serum 25-hydroxyvitamin D
[25(OH)D] levels below 80 nmol/L at one point in the
year, and that more than one-third of subjects had levels below the most
conservative definition of vitamin D
insufficiency, our findings support a recommendation for more aggressive
vitamin D supplementation, particularly for elderly people and especially
during the fall and winter months ... Low levels of vitamin D metabolites
are associated with
malabsorption
of calcium, which results in bone loss"
-
Soy Isoflavone May Improve Bone Metabolism in Perimenopausal
Women - Doctor's Guide, 5/27/02 -
"The isoflavone group (n=12) received daily capsules of soy isoflavone
extract (61.8 mg of isoflavones) ...
Excretion of bone resorption
markers was reduced significantly in the isoflavone group"
- Getting Calcium On Young Girls' Radar -
Intelihealth, 5/23/02 - "Ninety
percent of girls ages 9 to 12 don't get enough
calcium
in their diets ... Ninety to 98 percent of your skeletal system is developed
by age 20, so it's important that these bone-healthy activities are done
early. After that, you're either going to maintain the bone density or
you're going to lose it"
- Long-Time Tea Drinking Builds Strong Bones -
WebMD, 5/14/02
- Calcium and Vitamin D3 Effective and Cost-Saving in Preventing Hip Fracture
in Elderly European Women - Doctor's Guide,
5/13/02 - "simple dietary
supplementation with calcium and
vitamin D not only helps prevent hip fracture in institutionalized
elderly women, it also saves up to 711,000 Euros (some US $640,000) per 1000
treated ... One group received elemental 1200 mg/day calcium plus 800 IU/day
vitamin D3, while the other received a placebo. After three years, 25
percent fewer hip fractures were found among members of the supplemented
group ... The savings may even be greater than this: remember, this study
only takes into account hip fractures, but supplementation could prevent
many other types of fracture as well"
- Tea May Strengthen Bones - Intelihealth, 5/13/02
- Aging Bone Mineral Density Better With High Protein Diet Plus Extra Calcium,
Vitamin D - WebMD, 4/1/02
- High-Protein Diet Could Repair Bone Loss - WebMD,
3/25/02 - "The supplement group --
particularly those who ate a diet high in protein -- had significantly
better bone mass density -- an accurate measure of
bone loss. Those who took the placebo, however, had less
calcium absorbed into their bloodstream when they consumed more protein"
-
Does High Intake of Vitamin A Pose a Risk for Osteoporotic Fracture? -
JAMA. 2002 Mar 20;287(11):1396-7 -
"the evidence relating to a possible relationship between moderately high
retinol intake and possible adverse effects on bone health remains
inconclusive"
- Curbing Caffeine May Benefit Bones - HealthandAge,
1/11/02
- Kids Plagued by 'Calcium Crisis' - WebMD, 12/14/01
- "Only 14% of girls and 36% of boys
age 12 to 19 in the U.S. are getting the recommended amounts of calcium,
according to the U.S. Department of Agriculture ... Close to 90% of adult
bone is established by the end of the teen years. So if kids are off to a
bad start in getting enough calcium, says the National Institute of Child
Health and Human Development (NICHD),
down the road, they are at serious risk of developing the brittle-bone
disease osteoporosis as well as other bone diseases"
-
Calcium, Keep What You Take - Life Extension Magazine, 3/99
- Vitamin K
Deficiency Linked to Low Bone Mineral Density in Women
- Doctor's Guide, 10/15/01
-
Vitamin K Cuts Hip Fractures - Nutrition Science News, 9/01
- Vitamin E May Help Prevent Menopause Bone Loss -
WebMD, 6/28/01 - "Treating these
rats with vitamin E at a dose comparable to 400 IU in humans was just as
good as estrogen treatment in restoring bone density and weight"
- Study Relates Jogging And Strong Bones -
Intelihealth, 6/28/01 - "Young men
who jog regularly build strong bones and may be less likely to develop the
brittle bone disease osteoporosis ... For couch potatoes, men who do little
or no exercise, the bone density of joggers was almost 8 percent better"
-
Not for Ladies Only: Soy May Also Help Men at Risk for Osteoporosis -
WebMD, 4/2/01 - "research suggests
that a diet enriched with soy protein, which some research has shown can
help preserve women's bones, may be able to do the same thing for men ...
The group consuming soy protein had significantly more of this growth
factor"
-
PUFAs (omega-3 polyunsaturated fatty acids) for Bone Growth and Repair -
Nutrition Science News, 3/01
-
Vitamin C May Help Ward Off Osteoporosis - WebMD, 2/8/01 -
"Researchers have found that postmenopausal women who took vitamin C
supplements had a higher bone density than those who didn't. The highest
bone densities were also found in the women who were taking more than 1,000
mg/d."
-
High Impact Physical Activity Cuts Hip-Fracture Risk - Doctor's Guide,
1/18/01
-
Bone Up on Osteoporosis - Nutrition Science News, 11/00
-
Calcium Less Available from Soy Milk - Nutrition Science News, 10/00
- Supplemental Calcium Can Limit Early On-Set Of Osteoporosis In Children With
Asthma - Doctor's Guide, 10/16/00
- Bone Up on
Calcium Supplements, What Are Their Benefits and Risks? - WebMD, 9/19/00
-
Soy Isoflavones Reduce Bone Loss In Perimenopausal Women - Doctor's
Guide, 9/1/00
- Good Nutrition
Important for Prevention of Osteoporosis - WebMD, 5/19/00
-
There's Something to Be Said for Having 'Tea Bones' - WebMD, 4/14/00
-
Researchers Suggest Daily Tea May Fortify Bones Of Elderly Women -
Intelihealth, 4/7/00
-
Hearts & Bones: Calcium's Many Applications - Nutrition Science News,
2/00
- The Replacements - Nutrition Science News, 8/99
- Postmenopausal Bone Loss
Prevented With Low Dose HRT Plus Calcium - Doctor's Guide, 6/2/99
-
Osteoporosis: You can prevent it - CNN, 6/2/99
-
Can ipriflavone prevent osteoporosis? - Nutrition Science News, 5/99
-
Anti-dairy group opens campaign attacking benefits of milk - CNN, 3/1/99
-
Calcium supplementation prevents seasonal bone loss and changes in
biochemical markers of bone turnover in elderly New England women: a
randomized placebo-controlled trial - J Clin Endocrinol Metab 1998
Nov;83(11):3817-25
- Weight
training, calcium, hormones the key to fighting osteoporosis - CNN,
11/6/98
- Low Dietary Calcium, Low
Vitamin C Linked To Increased Risk Of Gum Disease - Doctor's Guide,
6/29/98
- Female Teens Need Calcium
During Window Of Opportunity - Doctor's Guide, 9/5/97
- Report:
Americans need more calcium - CNN, 8/13/97
CME:
-
Medscape osteoporosis CME courses
-
Doctor's Guide osteoporosis CME courses
-
Role
and Importance of Calcium in Preventing and Managing Osteoporosis -
Medscape, 3/30/06 - "Although very
high calcium intakes can overcome much of the absorptive block of vitamin D
deficiency, the amounts needed are considerably in excess of calcium
supplement doses used in most trials.[38] Therefore, unrecognized vitamin D
deficiency will also confound a trial of calcium. This is not merely a
theoretical concern. Various population-based studies indicate that
prevalence of inadequate vitamin D status is high,[39] and in some groups
nearly universal"
-
A Year
of PTH, Then a Year of Alendronate May Maintain BMD - Medscape, exp.
8/10/06
-
New Insights into Osteoporosis Management
- PowerPak.com, exp. 5/07
- Osteoporosis: A New Era in Recognition and Treatment
- Medscape, exp. 9/30/04
General Information:
-
Osteoporosis - American Academy of Family Physicians
- Osteoporosis - emedicine.com
-
Osteoporosis - FamilyDoctor.org
- Osteoporosis - Intelihealth
- What is osteoporosis? How is it prevented and treated?
- Drugstore.com
- The Changing Paradigm in Osteoporosis Treatment -
Physician's Weekly, 1/5/04 -
"Patients should wait 4 to 6 hours between doses of calcium servings because
the body will not absorb more than 500 mg at a time"
- The Low-Down On Osteoporosis - Intelihealth,
12/29/03
-
Options for Protecting Bones After Menopause - NY Times, 4/22/03
-
Treatment for Male Osteoporosis - Medscape, 2/25/03
-
Osteoporosis - Veritas Medicine
- Treatments for osteoporosis
- Medifocus.com
Other News:
-
Facial Wrinkles Linked to Lower Bone Density - WebMD, 6/7/11 -
"Researchers measured the number and depth of facial
wrinkles and the skin firmness of 114 women who were within three years of
their last menstrual period ... Women who had worse wrinkles also had lesser
bone density ... Pal thinks the connection may be a protein called type 1
collagen, a building block of skin and bone tissue, which is lost with age.
It is thought that this loss may be accelerated during menopause, when
hormone levels drop ... The strongest association of the facial wrinkles
with the bone was between the eyebrows ... When we looked at the effects of
sun exposure on skin, we did not see that women who had more sun exposure
had worse skin wrinkles"
-
Higher
bone mineral density is associated with a decreased risk of colorectal
adenomas - Int J Cancer. 2010 Oct 14 - "patients
in the highest tertile of total body BMD (>1.294 g/cm(2)) and in the middle
tertile (≥1.167 to ≤1.294 g/cm(2)) compared to those with a total body BMD
in the lowest tertile (<1.167 g/cm(2)) had a lower risk of colorectal
adenomas (highest vs. lowest tertile: OR=0.29 (0.10-0.84); middle vs. lowest
tertile: OR=0.26 (0.08-0.80); p-trend=0.02)"
-
Long
term use of oral bisphosphonates may double risk of esophageal cancer, study
finds - Science Daily, 9/2/10 - "Typically,
oesophageal cancer develops in one per 1000 people at age 60-79 over five years.
Based on their findings, the authors estimate that with five years' use of oral
bisphosphonates this would increase to two cases per 1000 people taking
bisphosphonates over five years"
-
High-protein diets may cause bone loss in older women, study - Nutra
USA, 7/8/10 - "Study 1 ... on average, all women
lost around 19 pounds, but those who ate the higher-protein, meat-containing
diet also lost bone mineral density by about 1.4 percent ... Study 2 ... All
women lost weight, but the groups that consumed the higher-protein
meat-containing diets again also lost bone mineral density by up to 1.4
percent compared to the control group ... In the first study, all the
participants con­sumed calcium supplements to achieve calcium intakes of
2,000mg per day. In the second study, about half of the participants
con­sumed calcium supplements ... However, in neither case were the
supplements found to impact the loss of bone density"
-
Many
Psychotropic Medications May Be Bad for Bones - Medscape, 5/27/10 -
"osteoporosis was found to be associated with the
use of selective serotonin reuptake inhibitors (SSRIs), mood stabilizers
other than lithium, and benzodiazepines. Use of tricyclic antidepressants
was protective"
-
Diabetes Weakens Your Bones - Science Daily, 9/28/09 -
"They observed increased levels of inflammatory
molecules, including TNF-α during fracture healing. The diabetic animals had
rapid loss of cartilage in the healing bones, which was due to increased
numbers of osteoclasts, cells that remove bone and cartilage. Factors that
stimulate osteoclast formation were regulated by both TNF-α and a downstream
mediator, FOXO1. These results suggest that diabetes-mediated increases in
TNF-α and FOXO1 may underlie the impaired healing of diabetic fractures"
-
Sex
Hormones Associated With Broken Bones In Older Men - Science Daily,
8/3/09 - "Low levels of estradiol or high levels of
sex hormone binding globulin (SHBG) are associated with an increased risk of
osteoporotic fracture in older men"
-
Popular
Class Of Diabetes Drugs Doubles Risk Of Fractures In Women - Science Daily,
12/10/08 - "We knew going into this study that there was
an association between thiazolidinediones and fracture risk ... these agents
double the risk of fractures in women with type 2 diabetes"
-
Adiponectin Is A Metabolic Link Between Obesity And Bone Mineral Density
- Science Daily, 11/25/08 - "adiponectin, a protein
secreted from adipocytes, is a metabolic link that can explain, in part, the
known positive relationship between obesity and both bone mineral density
and reduced susceptibility to fractures ... In summary, elevated circulating
adiponectin was associated with lower bone mass and weaker bones in growing
mice compared to control animals" - See my
adiponectin page for ways to increase it. -
Ben
-
Angiotensin II type 2 receptor blockade increases bone mass - J Biol
Chem. 2008 Nov 11 - "Treatment with
AT2 receptor blocker
significantly enhanced the levels of bone mass and this effect was based on
the enhancement of osteoblastic activity as well as the suppression of
osteoclastic activity in vivo" - That might be another good reason
for telmisartan as a
first line treatment for hypertension. See telmisartan at OffshoreRX.com.
-
Too Much Body Fat Bad for Bones? - WebMD, 10/31/08 -
"postmenopausal women with a higher proportion of
body fat tend to have lower bone mineral content"
-
Guidelines for Osteoporosis Treatment - WebMD, 9/15/08
-
New Test for Osteoporosis Fracture Risk - WebMD, 6/24/08
-
Testosterone Replacement Theraphy Beneficial In Men 60 And Older, Study
Suggests - Science Daily, 4/7/08 - "These
preliminary data show beneficial effects of testosterone therapy on bone
turnover markers in older men with low-to-normal testosterone concentrations
using both continuous and monthly cycled testosterone replacement"
-
Low
Testosterone Levels Associated With Risk Of Fracture In Men Over 60 -
Science Daily, 1/14/08 - "Although low levels of
estradiol and testosterone were associated with a higher risk of fracture in
men over 60, only the effect of testosterone was independent of other risk
factors, the authors conclude"
-
Chocolate consumption and bone density in older women - Am J Clin Nutr.
2008 Jan;87(1):175-80 - "Higher frequency of
chocolate consumption was linearly related to lower bone density and
strength (P < 0.05). Daily (>/=1 times/d) consumption of chocolate, in
comparison to <1 time/wk, was associated with a 3.1% lower whole-body bone
density; with similarly lower bone density of the total hip, femoral neck,
tibia, and heel; and with lower bone strength in the tibia and the heel"
-
Many Osteoporosis Medications Prevent Fractures, but None Is Proven Best
- Doctor's Guide, 12/18/07
-
Depression
Associated With Low Bone Mineral Density - Medscape, 12/3/07 -
"The novelty of this study is the fact that these
women were not severely depressed ... Depression is considered a disease of
chronic stress, Dr. Cizza said, with attendant increases in the stress
hormone cortisol, and cytokines produced by the immune system. "Those
substances are helpful to fight stress, but if there is too much cortisol or
cytokines, there are side effects," he said. "One of the side effects is
bone loss, so it was obvious to ask the question, 'do women with depression
have low bone mass?'""
-
New Diabetes Drugs Bad for Bones - WebMD, 12/3/07 -
"The diabetes drug Avandia promotes osteoporosis not
only by slowing bone growth but also by speeding up bone loss. Actos, the
only other drug in the same class, likely does this as well"
-
Depression Linked To Bone-thinning In Premenopausal Women - Science
Daily, 11/26/07 - "The researchers found that 17
percent of the depressed women had thinner bone in a vulnerable part of the
hip called the femoral neck, compared with 2 percent of those who were not
depressed"
-
Just Being Naturally Thin May Raise Risk of Osteoporosis in Women -
Doctor's Guide, 11/8/07
-
The association of sex hormone levels with quantitative ultrasound, bone
mineral density, bone turnover and osteoporotic fractures in older men and
women - Clin Endocrinol (Oxf). 2007 Jun 6 - "oestradiol (E2) and testosterone
(T) ... Low levels of bioE2 and bioT were found to be associated with high
bone turnover, low QUS and BMD and high risk of osteoporotic fractures in
both men and women"
-
Antidepressant Use May Boost Fracture Risk - Science Daily, 5/29/07 -
"people ages 50 and over who
regularly took antidepressants called selective serotonin reuptake
inhibitors (SSRIs) had double the rate of fractures as people not using such
medications"
-
Once-a-year Drug Reduces Fractures From Osteoporosis - Doctor's Guide,
5/4/07
-
Relation of Cortisol Levels and Bone Mineral Density Among Premenopausal
Women With Major Depression - Medscape, 5/4/07 -
"a lower BMD and increased bone resorption were found in women with mild depression. Major depression had
important effects on BMD and bone turnover markers. Depression should be
considered among risk factors for osteoporosis in premenopausal women,
therefore it may be useful to assess BMD values of MDD patients, and to
treat them in cases of lower BMD values"
-
Men
Warned Of Osteoporosis Problems - Science Daily, 1/31/07 -
"Statistically, one in three men die
following a fracture, compared to one in five women, possibly because of
underlying health problems such as heart disease which make it difficult for
them to cope with a fracture that could involve hip surgery, prolonged bed
rest and rehabilitation"
-
Study Says Depression May Weaken Bones - WebMD, 10/30/06 -
"After four weeks, the depressed
mice had lost bone density, the study shows. The problem: They had a drop in
bone-building cells called osteoblasts ... When the depressed mice drank
water laced with imipramine, their depression eased and their bone loss
stopped"
-
Study Links Cola to Bone Loss in Women - WebMD, 10/6/06 -
"drinking cola soft drinks on a
regular basis was associated with lower bone mineral density in the hip"
-
Low Bone Density May Predict Cognitive Impairment - Doctor's Guide,
5/5/06 - "Low bone mineral density
(BMD) in postmenopausal women may be associated with cognitive impairment,
and estrogen metabolism may be the cause"
-
Elderly Men Who Fall Should Be Screened for Osteoporosis - Doctor's
Guide, 5/5/06
-
Low Estrogen May Up Men’s Hip Fracture - WebMD, 5/3/06
-
Lack of Estrogen Linked to Hip Fractures in Men - Intelihealth, 5/1/06 -
"men who have lost bone mass should
take calcium and vitamin D supplements to help reverse bone loss and reduce
the risk of hip fractures ... This is an interesting paper and tends to
confirm that among men, estradiol (estrogen) levels may be more important to
bone strength than is testosterone"
-
FDA Approves Once-a-Week Osteoporosis Hormone Therapy Patch Climara Pro
(Estradiol/Levonorgestrel) - Doctor's Guide, 1/4/06 -
"the FDA has approved the hormone
therapy patch, Climara Pro® (estradiol/levonorgestrel transdermal system),
for the prevention of postmenopausal osteoporosis"
-
Women Over 50 Likely to Have Both Low Bone Mineral Density and Elevated
Cholesterol - Doctor's Guide, 10/4/05 -
"17.3 million (43%) of women over 50
years had
osteopenia, and 4.8 million (12%) had osteoporosis, while 18.2 million
(45%) had normal BMD"
-
Treating Osteoporosis: What Works Best? - WebMD, 8/10/05 -
"Treatment with parathyroid hormone
increases bone density. But women who took parathyroid hormone for a year
progressively lost bone density afterward unless they took Fosamax"
- What's
Best for Bones? - Dr. Weil, 5/13/05
-
Bone Fracture Rates Significantly Reduced Over Just Two Years in Patients
Who Consistently Stayed on Bisphosphonate Therapy for Osteoporosis -
Doctor's Guide, 4/7/05 - "We found
that women with postmenopausal osteoporosis who faithfully continued to take
their prescribed bisphosphonate medication reduced their risk for fractures
substantially more - about 25% - than women who did not"
-
Newer Antiepileptics May Increase Risk of Osteoporosis - Clinical
Psychiatry News, 4/05
-
Few Patients Exposed to High-Dose Corticosteroids Receive Osteoporosis
Education - Doctor's Guide, 3/28/05
-
More
Osteoporosis Seen With Raw Foods Diet - WebMD, 3/28/05
-
Osteoporosis and Bone Health - Physician's Weekly, 3/21/05 -
"half of all Americans older than 50
will be at risk for fractures from osteoporosis and low bone mass by 2020 if
no immediate actions are taken ... Calcium and vitamin D intakes are far
below recommended levels for all ages, sexes, and races in the United
States"
-
Dental X-Rays Could Be First Step in Osteoporosis Screening
- Doctor's Guide, 12/1/04
- Osteoporosis Drugs May Prevent Knee Arthritis -
WebMD, 11/4/04
- Four Osteoporosis Drugs Show No Difference in Impact on Endothelial Function
- Doctor's Guide, 10/11/04
- Ultra-Low Dose Estradiol Good for Bone Health, and Appears to Have No Impact
on Endometrium - Doctor's Guide, 10/11/04 -
"14 mcg of estradiol patch ... By the end of 2 years, there was a 2.6%
increase in bone mineral density of the lumbar spine over baseline, and a
0.4% increase in BMD at the hip. By comparison in the placebo group, the
increase in BMD of the spine was 0.6% and there was a loss in BMD at the hip
of 0.8% ... These ultra-low doses of estradiol should be sufficient to
preserve bone health in women over the age of 60 years"
- Declining Estradiol Levels More Predictive of Fracture Risk Than Low
Testosterone in Aging Men - Doctor's Guide,
10/8/04 - "While low levels of free testosterone are a predictor of
hip-bone loss, declines in estradiol levels play a stronger role than
testosterone"
- Exercise More Critical Than Calcium For Adolescent Bones
- Doctor's Guide, 6/9/04 -
"Exercise is more influential than calcium intake in determining bone
strength in young women ... attaining optimal bone mass and bone strength in
adolescence may offer the best protection possible against osteoporosis -
bone loss in post-menopausal women and the elderly"
- New Fracture Risk: High Homocysteine - WebMD,
5/12/04
- Postmenopausal Women Show Significantly Reduced Incident Fracture Risk While
on Hormone Therapy - Doctor's Guide, 5/12/04 - "We found a significantly reduced risk of fracture a year or
so after women had started using hormone therapy, with the risk decreasing
further with increasing duration of use"
- Ultra-Low Dose Estrogen Patch Helps Bones - WebMD,
5/4/04
- Ultra-Low-Dose Estradiol Patch Stops Bone Turnover, Increases Bone Density
- Medscape, 5/4/04 -
"The patch dose is "roughly one fourth of the standard 0.625-mg dose usually
prescribed for menopause symptoms ... That minimal increase translated into
a "3% increase in BMD at the spine compared to placebo and a 1.5% increase
at the hip compared to placebo ... All women received 800 mg calcium and 400
IU vitamin D daily"
- Peak Bone Mass, Size Appear Almost Fully Attained by Late Adolescence
- Doctor's Guide, 4/6/04
- Few Treated for Osteoporosis; Many at Risk -
WebMD, 3/26/04 -
"Researchers say recent advances in the prevention and treatment of
osteoporosis not only slow the bone-thinning disease, but they can also help
rebuild your bones ... The problem is, only a fraction of those at risk for
the disease are ever screened for osteoporosis"
- Inhaled Steroids: More Evidence of Bone Loss -
WebMD, 3/26/04
- Inverse Relationship Observed Between Statin Treatment and Risk of Hip
Fracture - Doctor's Guide, 3/12/04 -
"The risk of hip fracture decreased as the number of statin prescriptions
increased ... 0.72 ... for subjects who redeemed more than 3 statin
prescriptions"
- Statins May Help Prevent Bone Fractures - WebMD,
1/26/04 - "statin users had a
38%-81% lower risk of hip bone fractures and a 5%-51% lower risk of nonspinal
fractures ... statin use was associated with a 57% reduction in the number
of hip fractures reported and a 31% reduction in
nonspinal
fractures"
- Human Parathyroid Hormone Appears Effective, Safe in Increasing Bone Mineral
Density in Postmenopausal Osteoporosis - Doctor's
Guide, 11/20/03
- Is Low Bone Mass in Men an Underdiagnosed Disease State?
- Doctor's Guide, 10/31/03 - "The
leading three risk factors from the questionnaire for predicting bone loss
were history of smoking, no calcium supplementation, and difficulty
maintaining an erection ... 62.5% showed evidence of either
osteopenia
(> -1.0 SD of bone mass density [BMD]) or osteoporosis"
- More
Awareness of Guidelines to Prevent Corticosteroid-Induced Osteoporosis
- Medscape, 10/27/03
- Few Get Osteoporosis Drugs After Falls - WebMD,
10/2/03 -
"only 22% of elderly men and women who had a major bone fracture filled a
prescription for an osteoporosis drug within six months after their injury
... that's despite the fact that people who have suffered one fracture from
osteoporosis are up to five times more likely so suffer another one, and use
of osteoporosis drugs can reduce that risk of by as much as 60%"
- Statins Used to Treat High Cholesterol and Osteoporosis
- Doctor's Guide, 9/30/03 -
"simvastatin acts as a double therapeutic weapon by blocking the conversion
of HMG-CoA
to mevalonate.
Not only does this action increase new bone formation via the stimulation of osteoblasts,
but it also prevents the production of cholesterol"
- Men
Present With More Severe Osteoporosis Than Women -
Medscape, 9/25/03
- Most Postmenopausal Women With Fractures Not Prescribed Osteoporosis
Medications - Doctor's Guide, 9/26/03
- Postmenopausal Women with Fracture are Under-Treated
- Doctor's Guide, 9/24/03 -
"The majority of postmenopausal women with low trauma fracture are not being
treated with osteoporosis medications"
- Regular Cola Consumption Linked to Lower Bone Density in Women
- Medscape, 9/22/03 - "Among the
female subjects, regular cola drinkers had decreased BMD compared with the
infrequent drinkers. BMD was 2.3% lower in the trochanter,
3.3% lower in the femoral neck, and 5.1% lower in Ward's area ... When
phosphoric acid comes packaged with other nutrients, it's absorbed
normally and everything is in balance. We think the problem with cola is
that you're getting those doses of phosphoric acid without any calcium. It's
not balanced, and that extra phosphorus binds with calcium and prevents it
from being absorbed"
- Cessation of Hormone Replacement Results in Rapid Increase in Bone Turnover,
Bone Loss - Doctor's Guide, 9/2/03 -
"HRT
withdrawal was followed by significant bone loss, with an annual rate ranging
from -0.7 to -1.6% ... These findings have important implications for women
who are given HRT for preventing the risk of osteoporosis"
- Peak Bone Mineral Density Has Greatest Influence on Onset of Osteoporosis
- Doctor's Guide, 8/27/03
- Low-Dose Oestrogen Increased Bone Density in Older Women Without Increasing
Oestrogen-Associated Adverse Effects - Doctor's
Guide, 8/26/03 -
"They randomised
167 women, older than 65 years of age, to receive either 0.25 mg/day
micronized
17beta-estradiol or placebo for 3 years ...
patients treated with low-dose estradiol showed bone mineral density
increases of 2.6% at the femoral neck, 3.6% of the total hip, 2.8% at the
spine, and 1.2% in total body measurements. Similar bone mineral density
changes were seen between those who received and did not receive
progesterone"
- Male Master Cyclists at Potential High-Risk for Developing Osteoporosis
- Doctor's Guide, 7/24/03 - "Of the
master cyclists, 15% met the World Health Organisation's criteria for
having osteoporosis and 52% for having
osteopaenia at either the
spine or hip or both. This compares to 0% of the non-athletes who met the
criteria for osteoporosis and 42% who met the criteria for
osteopaenia ... The authors
recommend that cyclists supplement their training with weight-bearing
exercise, receive periodic BMD screening, and include adequate levels of
dietary calcium and vitamin D" - See
OS-Cal Plus at drugstore.com
.
- Osteoporosis Linked to Joint Destruction in Postmenopausal Rheumatoid
Arthritis - Doctor's Guide, 7/21/03 -
"Up to 56% of postmenopausal women with rheumatoid
arthritis (RA) who are not treated with hormone replacement therapy
(HRT) or bisphosphonates
develop osteoporosis"
-
Low Bone Mineral Density Is Associated With Future Dementia - Clinical
Psychiatry News, 7/03
- Menopausal Estrogen-Related Bone Loss Much Greater than Age-Related Bone
Loss - Doctor's Guide, 6/25/03 -
"In middle-aged women, age-related bone loss has a minor impact on the
metabolic activity of bone compared to the impact of
estrogen loss that accompanies menopause, which affects metabolic
activity and bone density to a larger degree"
- Too Much or Too Little Vitamin A Raises Hip-Fracture Risk in Post-Menopausal
Women - Doctor's Guide, 6/24/03 -
"the highest and lowest quintiles were at twice the risk of hip fracture
compared to the middle quintile ... without knowing the
vitamin A status of an individual, eliminating vitamin A supplements
could actually increase the number of vitamin A-deficient individuals, which
would put them at risk not only of hip fractures, but also for other health
risks associated with low vitamin A"
- Children on Frequent Oral Corticosteroids Should Maintain a Lifestyle that
Wards Off Osteoporosis - Doctor's Guide, 6/20/03
- Ulnohumeral Arthroplasty Improves Pain and Function in Elbow Osteoarthritis
- Doctor's Guide, 5/26/03
- Anti-hip Fracture Efficacy Lost with Estrogen Cessation
- Doctor's Guide, 4/29/03 -
"We found a statistically significant correlation between ending
estrogen and increased risk of hip fracture ... Among this sub-group,
the current users showed a statistically significant reduced tendency toward
hip fracture over never-users (0.10% of 67,973 vs. 0.28% of 53,737"
- Stronium Ranelate Potential New Option for Postmenopausal Osteoporosis
- Doctor's Guide, 4/28/03
- Simvastatin Enhances Bone Formation And Augments Bone Mineral Density
- Doctor's Guide, 4/24/03 - "After a
year's treatment with
simvastatin the increases in bone mineral
density at the lumbar spine, femoral neck and femur were 2.8, 1.0 and 0.8%
respectively. In contrast, lumbar spine, femoral neck and femur bone mineral
density declined by 1.6, 1.4, and 1.2% in the control group" - Note:
Red yeast rice is a non-prescription statin
but you should still check with your physician. See
iHerb
or
Vitacost
red yeast rice products.
- Boosting Bone Mineral Density Without Hormones -
WebMD, 3/25/03 - "experts urge women
who discontinued their hormones to get a bone mineral density test and
discuss new treatments for osteoporosis with their doctor ... The statistics
are staggering. One in two postmenopausal women has osteoporosis, 25% will
sufferer a spine fracture, and 15% will sustain a hip fracture as a result
... Depending on the results of the test, your doctor can prescribe one of
several drugs including
Fosamax,
Actonel, Evista,
the nasal spray Miacalcin,
and the newest drug on the block,
Forteo, an injectable form of human parathyroid hormone"
- Growth Hormone Increase Bone Content In Osteoporotic Postmenopausal Women
- Doctor's Guide, 3/12/03 - "80 osteoporotic postmenopausal women, aged between 50 and 70, who were using
oestrogen therapy (HRT), were
randomised
to receive either recombinant human growth
hormone (GH), 1.0 U or 2.5 U/day, subcutaneous, or placebo. Calcium (750
mg) and vitamin D (400 U) were given to all patients as well ... At 3 years,
when GH was discontinued, total body and femoral neck bone mineral content
had increased in both GH-treated groups, and differences were not
significant ... At the fourth year of follow-up, total body boner mineral
content had increased 5% and lumbar spine bone mineral content increased 14%
among women who received GH 2.5 U, and compared with placebo. Femoral neck
bone mineral density increased 5% and bone mineral content 13% for women
taking GH 2.5 U compared with those taking GH 1.0 U"
- Parathyroid Hormone [hPTH] May Increase Vertebral Bone Strength In Some
Postmenopausal Women - Doctor's Guide, 2/14/03
- PTHrP Leads To Significant Increase In Bone Mineral Density
- Doctor's Guide, 2/5/03
- Long-Distance Runners Risk Bone Loss - WebMD,
1/27/03
- News - Inhaled Corticosteroids Do Not Affect Bone Density
- Doctor's Guide, 1/24/03
- Daily Clodronate Prevents Early Postmenopausal Bone Loss
- Doctor's Guide, 1/8/03
- Oral Contraceptive Use May Preserve Bone Density in Some Women
- Doctor's Guide, 12/24/02
- Bone Loss Accelerated After Solo Estrogen Withdrawal For Some Postmenopausal
Women - Doctor's Guide, 12/10/02 -
"An acceleration of bone loss is seen after withdrawal of
oestrogen therapy but not after withdrawal of alendronate alone or
combination therapy with oestrogen"
- Several Bone Metabolism Factors Affect Hip Fracture Risk in Postmenopausal
Women - Doctor's Guide, 12/5/02
- Micro-CT Scans Provide 3-D Proof of Estrogen's Bone Benefit
- Medscape, 12/3/02 -
"A three-dimensional glimpse of bone micro-architecture suggests that
estrogen replacement is an effective treatment
for osteoporosis because it "protects and retains bone structure, rather
than laying down new bone,""
- Bone Loss in Men with Steroid Induced Osteoporosis May Be Due to Low
Oesetradiol Levels - Doctor's Guide, 11/18/02
- Men With Hip Fracture Seldom Osteoporosis Therapy
- Doctor's Guide, 11/13/02
- Light Exercise Won't Make Bones Strong - WebMD,
11/1/02 - "The
fittest people were at just the same risk for brittle bones as those who
gasped for breath after a short time on the treadmill"
- Osteoporosis Not Just for Women - WebMD, 10/28/02
- Fracture Treatment Differs - Intelihealth,
10/28/02 - "Thirty-two
percent of the men died within a year of their fractures. Many deaths were
likely from ailments linked to the weakened condition of being immobilized
by the fractures, which may have been preventable with treatment for
osteoporosis or underlying conditions that can cause it ... In men, low
testosterone levels, alcoholism and excessive use of steroid medicines can
cause low bone density and can often be treated"
- Hormone Therapy Plus Alendronate Better for Bone Density than Hormone
Therapy Alone - Doctor's Guide, 10/8/02
- Testosterone supplementation provides additional BMD gains in hypogonadal
men following cardiac transplantation - Doctor's
Guide, 9/23/02 - "hypogonadal
men who received additional testosterone
supplementation showed the largest increases in BMD [bone mineral density]"
- Height Loss Good Index for Ruling Fracture Risk Out in General Practice
Setting - Doctor's Guide, 9/23/02
- Secondary Causes of Osteoporosis Higher in Fracture Patients
- Doctor's Guide, 9/23/02 -
"The most common cause of secondary osteoporosis is
corticosteroid excess, whereas others include malignancy, gastric
surgery, alcoholism, and anticonvulsant therapy use. Prior studies have
shown that as many as 30 percent of postmenopausal women exposed to
corticosteroids demonstrate causes of secondary osteoporosis"
- Bisphosphonates Safe in Renally Impaired Osteoporosis Patients
- Doctor's Guide, 9/23/02
- Osteoporosis Under-Recognized at Time of Admission to Nursing Home
- Doctor's Guide, 9/23/02 -
"New data confirm that few patients in nursing homes are on
osteoporosis-related treatments despite the known high prevalence of
osteoporosis in this population"
- Low Bone Mineral Density Common in Elderly Black Women
- Doctor's Guide, 9/23/02 -
"New findings document that 60 percent of elderly African-American women
have a low bone mineral density (BMD)"
- Primary Care Residents Don't Screen for Osteoporosis
- Doctor's Guide, 9/23/02 -
"Primary care residents assess women who are at risk for postmenopausal
osteoporosis at a rate far below that for other common health conditions ...
She also pointed out that the results are regrettable since osteoporosis is
a prevalent chronic health problem with associated morbidity and mortality
outcomes on a par with other chronic illnesses such as
hypertension,
hypercholesterolemia, and diabetes. Also,
the disease is preventable"
- Secondary Causes of Osteoporosis Higher in Fracture Patients
- Doctor's Guide, 9/23/02 -
"The most common cause of secondary osteoporosis is
corticosteroid excess, whereas others include malignancy, gastric
surgery, alcoholism, and anticonvulsant therapy use. Prior studies have
shown that as many as 30 percent of postmenopausal women exposed to
corticosteroids demonstrate causes of secondary osteoporosis"
- Low-Carbohydrate, High-Protein Diets Increase Risk Of Kidney Stones And May
Raise Bone Loss Risk - Doctor's Guide, 8/1/02 - "acid excretion - a marker for the acid load in the blood -
increased as much as 90 percent while subjects were on
diets that severely restricted
carbohydrates. Levels of urinary citrate, which inhibits
kidney stones, fell by almost 25 percent in the group during the
six-week study ... People may lose weight on this diet, but this study shows
that this is not a healthy way to lose weight ... there was an increased
risk of developing kidney stones and a possible increase in the risk of bone
loss"
- Relation of Statin Use and Bone Loss: A Prospective Population-Based Cohort
Study in Early Postmenopausal Women - Doctor's
Guide, 7/15/02
- Osteoporosis in Elderly Men Underestimated -
Doctor's Guide, 6/24/02 - "As many
as 30 percent of men over 65 years old may have osteoporosis ... The serum
thyroid-stimulating hormone (TSH), although normal, was slightly lower in
men with osteoporosis, an average of 1.57±0.74 in comparison to an average
of 2.34±1.93 in men with no osteoporosis ... Because both groups of men have
low-normal 25-OH vitamin D, and low urinary
calcium, the investigators suggest that patients
in their situation, could benefit from enhancing their nutritional status"
- Epilepsy Drugs Are Risk Factors For Osteoporosis -
Doctor's Guide, 6/20/02 -
"Epilepsy and its therapies - older or modern
- are both risk factors for low bone density, irrespective of
vitamin D levels"
- Daily Oral Pamidronate Effective, Safe In Established Osteoporosis
- Doctor's Guide, 6/17/02
- Triple Combination Incorporating Hormone Replacement May Protect Against
Osteoporotic Fractures - Doctor's Guide, 6/7/02
- Irregular Periods In Young Women Could Be Warning Sign For Later
Osteoporosis - Doctor's Guide, 5/29/02 -
"Irregular
menstrual periods in young women may be a warning sign of a
hormonal shortage that could lead to osteoporosis"
-
Effect of Lower Doses of Conjugated Equine Estrogens With and Without
Medroxyprogesterone Acetate on Bone in Early Postmenopausal Women -
JAMA. 2002 May 22-29;287(20):2668-76
-
Vivelle-Dot (Estradiol Transdermal System) Now Approved In New, Low Dose For
Postmenopausal Osteoporosis Prevention - Doctor's Guide, 5/21/02 -
"Vivelle-Dot
is now approved in the 0.025 mg/day dosage strength, providing among the
lowest effective ERT
dosage strengths available in the U.S. for the prevention of postmenopausal
osteoporosis"
- Nandrolone Decanoate Increases Bone Mineral Density in Elderly Patients with
Osteoporosis - Doctor's Guide, 5/15/02
- Strontium Ranelate Reduces Vertebral Fracture Risk in Postmenopausal
Osteoporosis - Doctor's Guide, 5/15/02
- Teriparatide (Parathyroid Hormone) Increases Vertebral Bone Mineral Density
in Men Irrespective of Osteoporosis Secondary Cause Factors
- Doctor's Guide, 5/15/02
- Strontium Ranelate Reduces Vertebral Fracture Risk in Postmenopausal
Osteoporosis - Doctor's Guide, 5/14/02
- Intermittent Oral Ibandronate Reduces Fracture Risk in Postmenopausal Women
- Doctor's Guide, 5/14/02
- Reduction in Bone Turnover Markers Convenient, Practical Way to Monitor
Osteoporosis Therapy - Doctor's Guide, 5/14/02
- FDA Approves New Indication, Strength of Alora (Estradiol Transdermal
System) for Prevention of Postmenopausal Osteoporosis
- Doctor's Guide, 4/9/02 -
"These approvals add a new
indication, prevention of postmenopausal osteoporosis, and a new strength,
0.025mg/day, to the Alora
label"
- Protein [Runx or core binding factor A] May Help Bone Growth
- Intelihealth, 4/8/02
- Investigation Of Bone Loss After Discontinuation Of Hormone Replacement
- Doctor's Guide, 4/5/02
-
Bone Mass Response to Discontinuation of Long-term Hormone Replacement
Therapy: Results From the Postmenopausal Estrogen/Progestin Interventions
(PEPI) Safety Follow-up Study - Arch Intern Med. 2002 Mar
25;162(6):665-72 - "Rates of
BMD loss among women who
stopped HRT during or after the
PEPI-RCT
[Postmenopausal Estrogen/Progestin Interventions randomized controlled trial]
did not differ significantly from those of women who did not undergo HRT,
who lost bone at a rate of approximately 1% yearly during the first year of
the PEPI-RCT
and about half that rate afterward. Women who continued HRT after the
PEPI-RCT did not show
additional BMD
gains"
- Bone Loss Resumes at Normal Rate When Hormone Replacement Therapy is Stopped
- Doctor's Guide, 3/25/02
- Risk of Fracture Reduced in Women Using Statins -
Doctor's Guide, 3/19/02 - "Fracture
risk is reduced by 60 percent in women using 3-hydroxy-3-methylglutaryl
coenzyme A reductase
inhibitors (statins) ... This substantial risk reduction is greater than
might be anticipated from increases in bone mineral density (BMD)
alone"
- Estradiol Via Matrix Patch Reverses Bone Loss -
Doctor's Guide, 3/12/02 - "Transdermal estradiol
delivered by matrix patch reversed bone loss in
hysterectomized,
post-menopausal women and produced few side effects"
-
Statin Use, Bone Mineral Density, and Fracture Risk: Geelong Osteoporosis
Study - Arch Intern Med. 2002 Mar 11;162(5):537-40 -
"The substantial 60% reduction in fracture risk associated with statin use
is greater than would be expected from increases in
BMD
alone"
- Simvastin Has No Effect On Bone Formation or Resorption in Osteopenia
- Doctor's Guide, 3/8/02
- Preventing Bone Loss, on a Yearly Basis - WebMD,
2/27/02
- Calcitonin Boosts Trace Minerals In Postmenopausal Osteoporotics
- Doctor's Guide, 2/5/02
-
Osteocalcin Tied To Bone Loss, Fracture In Elderly - Doctor's Guide,
2/5/02
- Fluoride Aids Bone Health - HealthandAge, 1/11/02
- Bisphosphonates And Hormone Replacement Preferred For Osteoporosis
Prevention - Doctor's Guide, 12/18/01
- Postmenopausal Bone Loss Studied - Intelihealth,
12/12/01
-
Study: Estrogen Therapy Significantly Improves Bone Density In Elderly Women
- Intelihealth, 8/15/01
- Estrogen Increases Bone Mass in Women Over 75 -
WebMD, 8/14/01
- New
Guidelines Recommend Bisphosphonates For Prevention, Treatment of
Glucocorticoid-Induced Osteoporosis - Doctor's
Guide, 7/19/01
- Increased
Bone Density Following Two Years Of Growth Hormone Treatment In Men With
Idiopathic Osteoporosis - Doctor's Guide, 6/24/01
- Growth Hormone,
Alendronate And Tissue-Selective Estrogen All Effective In Osteoporosis
- Doctor's Guide, 6/21/01
- Weekly Fosamax
(Alendronate) Shows Equivalent Increases In Bone Density as Daily Regimen
- Doctor's Guide, 6/20/01
- Once-Weekly
Fosamax Effective For Osteoporosis - Doctor's
Guide, 6/17/01
- Early Hormone-Replacement
Therapy Helps Prevent Osteoporotic Fractures - Doctor's Guide, 6/14/01
- Estrogen's
Benefit on Bone Questioned - WebMD, 6/12/01 -
"If you're over age 60, it would seem that the evidence isn't as strong that
it works. ... You might be better to consider an alternative medication
where there is better evidence of effectiveness ... Those alternatives
include drugs that have been proven effective for preventing and treating
osteoporosis such as Evista, Fosamax, Actonel, and the hormone calcitonin"
- Fewer Gastric Ulcers With
Risedronate Compared To Alendronate - Doctor's Guide, 5/25/01
-
Promising New Osteoporosis Treatment Boosts Bone Growth - Intelihealth,
5/16/01 - "Injections of parathyroid
hormone increase bone density and reduce the risk of fractures in the neck
and spine, offering a potential new treatment for many cases of
osteoporosis"
-
Natural Hormone Helps Osteoporosis - Intelihealth, 5/10/01 -
"A natural bone-building hormone appears to be the most effective treatment
ever for osteoporosis ... The manufacturer hopes the medicine, called Forteo
(for-TAY-oh), will be available by prescription by the end of the year ...
drug is based on the parathyroid hormone, which is ordinarily secreted by
tiny glands in the neck. When given to volunteers with osteoporosis, it
doubles their normal rate of bone formation"
-
It's Never Too Late to Treat Osteoporosis, Even Advanced Disease Benefits
From Therapy - WebMD, 5/3/01
- New
Guidelines Aim To Improve Osteoporosis Awareness Among Women And Physicians
- Doctor's Guide, 5/1/01
- Childhood
Cancer Survivors at Greater Risk for Osteoporosis
- Doctor's Guide, 4/30/01
-
Osteoporosis Supplement Doesn't Prevent Bone Loss In Study -
Intelihealth, 3/20/01 -
"ipriflavone, a synthetic form of an estrogen-like substance found in plants
such as soybeans ... ipriflavone supplements had no effect on preserving
bone density. But women who took the supplements, in standard doses of 600
milligrams daily, were more likely than those on dummy pills to develop a
reduction in disease-fighting white blood cells called lymphocytes ...
The women remained otherwise healthy, but low lymphocyte counts are a
symptom of an immune system that is potentially more vulnerable to infection
... The study was funded by Chiesi Pharmaceuticals Inc., an Italian maker of
ipriflavone (so it may have been that brand)"
-
Ultrasound Takes Osteoporosis by the Heel, New Device Might Replace Bone
Scans - WebMD, 2/20/01
-
Fatty diet could lead to thin bones -- study - CNN, 12/20/00
-
Kids Taking Steroids for Asthma Need Calcium and Exercise - WebMD,
10/20/00
- Early Intervention In
Osteoporosis Vital In Effective Treatment - Doctor's Guide, 10/3/00
- Study
Raises Serious Questions About Osteoporosis Care -
Doctor's Guide, 8/25/00
- FDA Approves Vivelle
(estradiol transdermal system) For Postmenopausal Osteoporosis -
Doctor's Guide, 8/18/00
-
Cholesterol-Lowering Drug May Protect Women From Bone Fractures -
Intelihealth, 6/23/00
- Parathyroid Hormone -
Newest Treatment On Horizon For Osteoporosis - Doctor's Guide, 6/19/00
- Bone Loss
In Osteoporosis Still Not Detected Early Enough To Prevent Fractures
- Doctor's Guide, 6/16/00
- Majority Of
Women Treated For Osteoporosis Not Taking Calcium Supplements
- Doctor's Guide, 6/15/00
-
Rheumatoid Arthritis Patients at Higher Risk for Bone Loss - WebMD,
4/28/00
- FDA
Approves Activella (Estradiol/Norethindrone ) For Prevention Of
Postmenopausal Osteoporosis - Doctor's Guide, 4/14/00
- NIH Panel Issues Statement
on Osteoporosis Prevention, Diagnosis, and Treatment - Doctor's Guide,
3/29/00
- Mysterious
Foot Fractures May Be Sign Of Osteoporosis - Doctor's Guide, 3/21/00
-
Contradictory Findings: Fluoride Does Increase Risk Of Hip Fractures -
Doctor's Guide, 2/24/00
- Men With
Chronic Lung Disease At High Risk For Osteoporosis
- Doctor's Guide, 12/14/99
-
Cholesterol-lowering drugs may lead to osteoporosis treatments - CNN,
12/3/99
- Testosterone Therapy
Effective For Men With Osteoporosis - Doctor's Guide, 11/17/99
- Newest drug for osteoporosis has fewer side-effects
- CNN, 10/13/99
- Spinal
Fractures Linked To Lower Quality of Life, Increased Risk of Depression
- Doctor's Guide, 10/4/99
- Researchers Link
Hypertension And Osteoporosis - Doctor's Guide, 9/17/99
- Treatment
Options For Preventing Osteoporosis - Doctor's Guide, 5/19/99
-
Prostate Cancer Therapy Adds To Men's Osteoporosis Risk - Intelihealth,
5/18/99
-
Corticosteroid Treatment Increased Risk Of Vertebral Fracture - Doctor's
Guide, 12/14/98
- Majority Of American Women
Unaware Of Most Common Osteoporosis Fracture Site - Doctor's Guide,
12/4/98
- Osteoporosis
Linked With Lung Disease In Men, Says Study -
Doctor's Guide, 11/10/98
-
Guidelines to prevent, diagnose and treat osteoporosis expected - CNN,
11/5/98
- Osteoporosis And Oral
Health Closely Linked, Study Shows - Doctor's Guide, 2/16/98
- Majority Of
Fracture Patients Not Investigated For Osteoporosis
- Doctor's Guide, 1/23/98
- Biphosphonates May Help Avoid Corticosteroid-Induced Osteoporosis
- Doctor's Guide, 11/10/97
- Misconceptions Keep Some
Wormen for Taking Action on Osteroporosis - Doctor's Guide, 10/9/97
- National
Osteoporosis Foundation Comments On New Osteoporosis Study
- Doctor's Guide, 9/11/97
- Women Confuse Bone-Thinning
Disease with Arthritis - Doctor's Guide, 7/2/97
- PMS
Management Prevents Osteoporosis - Doctor's Guide,
5/30/97
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