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Anti-aging Research > Coenzyme Q10.
Coenzyme Q10 (ubiquinone)
Specific Recommendations:
News & Research:
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Coenzyme Q10
- Vitacost Health Library
- Coenzyme Q10
- The Natural Pharmacist
-
Coenzyme Q10 for Energy and Heart Support - Dr. Murray (.pdf)
- Neurological
Health—CoQ10 - natmedonline.com
- CoQ10 - Heart
disease - natmedonline.com
-
Coenzyme Q10 Summary - U. of Texas Alternative Medicine
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Coenzyme Q10 - U. of Texas Alternative Medicine
- There
seems to be a lot of hype about the benefits of CoQ10. Can you separate out
the hype and tell me if I really need this supplement? - Dr. Murray
- I am
taking the drug Lipitor to lower my cholesterol. I have heard that I need to
take CoQ10 to offset a side effect of the drug - Dr. Murray
-
Coenzyme Q10
- thenutritionreporter.com
-
Wrinkle creams:
Your guide to younger looking skin - CNN -
"Coenzyme Q10 is a nutrient that
helps regulate energy production in cells. Some studies have shown reduction
in fine wrinkles around the eyes with no side effects"
-
CoQ10 may cut muscle injuries for athletes - Nutra USA, 5/5/08 -
"The volunteers had daily training sessions of five
and a half hours per day for six days during the intervention period. At day
three and five of the six day training period, the researchers report that
both groups experienced increased in serum creatine kinase activity and the
concentration of myoglobin, but these increases were significantly lower in
the group receiving the CoQ10 supplements ... Elevated levels of the enzyme
are indicative of muscle damage and injury ... levels of lipid peroxide, a
marker of oxidative stress, were also lower in the CoQ10 group after three
and five days of training" - [Abstract]
-
Migraine Patients May Benefit From Magnesium or CoQ10 - Clinical
Psychiatry News, 8/07 - "The most important
supplement, according to Dr. Mauskop, is magnesium. “It's known that up to
50% of people with acute migraine have a magnesium deficiency. … It is much
more effective to treat them with a product they're deficient in rather than
using drugs,” ... Research has found that, for migraine, CoQ10 at 300 mg/day
is effective, and that for Parkinson's disease 1,200 mg/day is effective"
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Report: Has Your Coq10 Become Obsolete? - Life Extension Magazine, 1/07
- "scientists have demonstrated that
the ubiquinol form of CoQ10 provides anti-aging effects that are far
superior to those associated with the conventional ubiquinone form used by
millions of Americans each day" - See
Jarrow Ubiquinol at iHerb
 .
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Novel Form Of Coq10 - Life Extension Magazine, 12/06
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Coenzyme Q10 review - ConsumerLab.com, 10/16/06
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More support for CoQ10’s benefits for heart health - Nutra USA, 9/12/06
- "the heart's functional capacity
improved significantly by nine per cent, as measured by the peak volume of
oxygen consumed (VO2), for the CoQ10 compared to placebo"
-
Report: Coq10'S New Benefits - Life Extension Magazine, 8/06
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CoQ10 may protect against Alzheimer’s - Nutra USA, 4/24/06
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Coenzyme Q10 for Migraine Prophylaxis - Clinical Psychiatry News, 3/06 -
"150 mg of coenzyme Q10 each day ...
The study's primary outcome measure was the percentage of patients who
achieved a greater than 50% reduction in the number of days with migraine. A
total of 61.3% of patients met that outcome measure by 3 months, and 93.5%
had at least a 25% reduction"
-
CoQ10’s “Other” Health Benefits
- Life Extension Magazine, 2/06 -
"The latest findings suggest that, along with its heart-protective effects,
CoQ10 may slow or improve some degenerative diseases, support cancer
remission, counteract the toxic effects of chemotherapy, and decrease the
incidence of migraine headaches. Additionally, recent findings indicate that
coenzyme Q10 may have applications in promoting fertility, protecting
auditory function, supporting longevity, boosting learning capability,
sustaining muscle health and much more"
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Coenzyme Q10 New Applications for Cancer Therapy
- Life Extension Magazine, 10/05
-
Four
powerhouse nutrients - Functional Foods and Nutraceuticals, 4/05 -
"L-carnitine shuttles fuel into
cells to be burned as energy; coenzyme Q10 sparks the energy within the
cells; ribose is a component of adenosine triphosphate (ATP); and
alpha-lipoic acid increases ATP levels"
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Coenzyme Q10 Lessens Muscle-Related Side Effects in Patients on Statins
- Doctor's Guide, 3/7/05 - "Patients
with significant myopathy who are taking statin therapy have a significant
decrease in myopathic pain after 30 days of supplementation with coenzyme
Q10" - See
iHerb
or
Vitacost
coenzyme Q10 products.
- The high five for hypertension - Functional Foods
& Nutraceuticals, 12/04 -
"Co-enzyme Q10 ... Omega-3 fatty acids ...
Garlic ... L-arginine ...
Calcium"
-
Innovative Research and Applications for CoQ10 - Life Extension
Magazine, 8/04 - "biomedical
researchers are discovering that CoQ10 shows promising effects against
disorders as far-ranging as kidney failure, heart disease, muscular
dystrophy, and macular degeneration"
- Proprietary CoQ10 formulation demonstrates superior absorption
- Nutra USA, 6/30/04
- Atorvastatin Reduces Blood CoQ10 Levels -
Medscape, 6/22/04 - "Even brief
exposure to atorvastatin causes a marked decrease in blood CoQ10
concentration ... Widespread inhibition of CoQ10 synthesis could explain the
most commonly reported adverse effects of statins, especially exercise
intolerance, myalgia, and
myoglobinuria"
- Coenzyme Q10 May Ward Off Migraine Attacks -
Medscape, 4/29/04 - "migraine
may be caused by a decrease in mitochondrial energy reserve ... 100 mg of
CoQ10 three times a day ... Approximately 48% of those who took CoQ10 had a
50% response rate during the three-month study, while this occurred in about
14% of those taking a placebo"
-
Coenzyme Q10 & Fertility - Physician's Weekly, 4/5/04
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Cardiologists Overlook Lifesaving Discovery - Life Extension Magazine,
2/04
- Coenzyme Q10 May Play Positive Role in Treatment of Male Infertility
- Medscape, 1/30/04 - "Patients
underwent oral administration of CoQ10, 200 mg/day twice daily for six
months ... After treatment, CoQ10 levels increased in seminal plasma; the
mean value rising significantly from 42.0 ± 5.1 ng/mL
at baseline to 127.1 ± 1.9 ng/mL
after six months of CoQ10 administration"
- Coenzyme Q10 review - ConsumerLab.com, 1/13/03 -
"There was no detectable CoQ10 in one product, another had only 71% of its
claimed amount, and a third exceeded its claimed amount by 75%"
- Coenzyme Q10 Helps Sperm Movement - WebMD, 1/12/04
- "Researchers say coenzyme Q10 is
known to be active in the testes and is an antioxidant that plays an
important role in forming the membranes and other structures within cells by
fighting the effects of oxidative stress ... researchers looked at the
effects of daily oral supplementation with 200 mg of coenzyme Q10"
- Reason for concern? - Wellness Insider, 11/25/03 -
"Dr. Golomb
feels the potential side effects of statins, which include liver
dysfunction, muscle pain (rhabdomyolysis), and potentially, muscle
breakdown, have been significantly downplayed. She also feels that statins,
especially at higher doses, contribute to memory loss and to the depletion
of coenzyme Q10, a naturally occurring antioxidant-like nutrient vital to
the production of energy"
- Water Soluble Form of Coenzyme Q10 Suggested for Migraine Prophylaxis
- Doctor's Guide, 9/30/03 -
"researchers used a new water-soluble form of coenzyme Q10 at 100 mg three
times daily for migraine prophylaxis ... Of the Q10 group, 47.6% of the
patients had a 50% response for attack frequency, compared to 14.3% for the
placebo group, resulting in a therapeutic gain of about 33.3%"
- Coenzyme Q10 Beneficial for People with Kidney Failure
- New Hope Natural Media, 7/17/03
- Guarding
Your Gums? - Dr. Weil, 6/16/03 -
"Periodontal disease is a chronic gum infection
caused by bacteria in plaque ... Coenzyme Q10: Take 120 mg per day of a
soft-gel form with meals ... young women who get less than 800 mg of
calcium a day have double the risk of periodontal disease" - See
iHerbor
Vitacost
coenzyme Q10 products.
- What Should We Advise Our Patients About Taking Antioxidants?
- J Clin Hypertens 5(3):231-233, 2003 via Medscape - "At
least two randomized trials of the effects of coenzyme Q10 (another
antioxidant) on blood pressure have been reported. In the first,[20] 59
treated hypertensives were randomized to either coenzyme Q10 (60 mg twice
daily) or vitamin B (placebo); after 8 weeks, clinic
blood pressure was 14/7 mm Hg lower in the treated group. In the
second,[21] 83 patients with isolated systolic hypertension were treated
with coenzyme Q10 (using the same dose as the earlier study) for 12 weeks.
The mean reduction of blood pressure was 17.8/7.3 mm Hg"
- Coenzyme Q10 Deficiency Associated with Genetic Coordination Disorder
- New Hope Natural Media, 6/12/03
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How To
Prevent Breast Cancer Anti-Cancer Power of Coenzyme Q10 - Life Extension
Magazine, 1/96
- Coenzyme Q10 Improves High Blood Pressure - New
Hope Natural Media, 1/9/03 -
"recruited 83 people with a condition called isolated systolic
hypertension
(ISH), in which the higher blood pressure ... These people were assigned to
take either 60 mg of CoQ10 twice daily or a placebo for 12 weeks ... The
people taking CoQ10 had an 18-point (18 mm Hg) reduction in systolic blood
pressure (from 165 to 147 mm Hg), compared with only a 2-point decline in
the placebo group ... ISH is the most common type of high blood pressure in
the United States"
-
The First Therapy Shown To Slow Progression of Parkinson's Disease -
Life Extension Magazine, 1/03
- Coenzyme Q10 Appears To Slow Parkinson's Disease Progression
- Doctor's Guide, 11/6/02
- Study Suggests Coenzyme Q10 Slows Functional Decline In Parkinson's Disease
- Doctor's Guide, 10/15/02
- Coenzyme Q10 May Slow Parkinson's - WebMD,
10/14/02 - "High doses of the
popular supplement coenzyme Q10 helps slow the progression of
Parkinson's disease in some patients by as much as half ... Their study,
published in the Oct. 15 issue of Archives of Neurology, is the latest to
examine the possible benefits of coenzyme Q10, a vitamin-like compound
naturally produced in the body and used by cells to make energy and protect
against cellular damage"
- MEDLINE Abstracts: Antioxidants and the Aging Brain
- Medscape, 9/27/02 - "Combinations
of antioxidants might be of even greater
potential benefit for AD, especially if the agents worked in different
cellular compartments or had complementary activity (e.g.
vitamins E, C and ubiquinone).
Naturally-occurring compounds with antioxidant capacity are available and
widely marketed (e.g.
vitamin C, ubiquinone,
lipoic acid, beta-carotene,
creatine, melatonin,
curcumin) and synthetic compounds are under development by industry"
- Again, a broad spectrum of anti-oxidants, not just one or two.
- CoQ10, the Wonder Nutrient
- Vitacost, 9/6/02 -
"It was found that the concentrations of CoQ10 were significantly decreased
in both plasma and whole blood of asthmatic sufferers compared with that of
the healthy volunteers. The researchers speculated that sub-optimal
concentrations of CoQ10 may play a possible contribution in patients with
asthma"
-
Dr. Julian M. Whitaker Petitions FDA to Include CoQ10 Use Recommendation in
All Statin Drug Labeling - Life Extension Magazine, 8/02 -
"On May 23, 2002, Dr. Julian M. Whitaker filed two citizens petitions with
the Food and Drug Administration. The petitions call on the Commissioner of
Food and Drugs to change the labeling of all
HMG CoA
reductase
inhibitor drugs (the so-called statin drugs),
and to issue a Medication Guide, warning consumers of the need to take
coenzyme Q10 (CoQ10) whenever they take a statin drug"
- Coenzyme Q10 Effective for Migraine Prevention -
New Hope Natural Media, 7/18/02 -
"In the new study, 31 migraine sufferers were
given 150 mg of
CoQ10 per day for three months. The average number
of days per month on which participants experienced headaches was 60% lower
during the last two months of CoQ10 treatment than during the month prior to
treatment. In addition, the average number of migraine attacks per month
decreased by 42% with CoQ10 ... Two other nutrients that play a role in
intracellular energy production (magnesium
and riboflavin) have also been shown to
reduce the recurrence rate of migraines"
-
How CoQ10 Protects Brain Cells - Life Extension Magazine, 10/01 -
"Newly published research suggests that CoQ10 can protect brain cells from neurotoxicity and excitotoxicity, while even powerful antioxidants cannot.
CoQ10 proved highly effective, while simple antioxidants were ineffective,
in protecting PC-12 cells (neuron-like rat adrenal cells commonly used in
neurobiological research) from the excitotoxic effects of glutamate and from
the Parkinson’s disease-like effects of the neurotoxin MPP+. L-deprenyl (the
drug selegilene) also proved effective, though not as effective as CoQ10"
-
ACSM Conference Unveils Performance Enhancers - Nutrition Science News,
9/01 - "Researchers have found that
coenzyme Q10 (Co-Q10 or ubiquinone)
can lower blood pressure in hypertensive people"
- CoQ10 Shows Promise In Slowing Progression Of Huntington's Disease
- Intelihealth, 8/23/01
- Coenzyme
Q10 Improves Cardiac Function in Children with Dilated Cardiomyopathy -
Doctor's Guide, 5/30/01
-
Bioenergetic Therapy for Aging - Life Extension Magazine, 2/01
-
Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99
- Patients
With Hereditary Ataxia Show Improvement With CoQ10 (Ubiquinone) -
Doctor's Guide, 4/10/01
-
Trial of Coenzyme
Q10 in Isolated Systolic Hypertension - Medscape, South Med J
94(11):1112-1117, 2001 - "The
mechanisms underlying essential hypertension remain uncertain. A causal role
for insulin resistance has been suggested,[35] and high levels of plasma
insulin have frequently been found in patients with high blood pressure"
-
How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine,
4/00
-
Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00
- "A large number of drugs deplete
Coenzyme Q10. These include such widely used tricyclic antidepressants as Elavil (amitriptyline) and Tofranil (imipramine), the anti-psychotic drug
Haloperidol, cholesterol-lowering statin drugs such as Lovastatin and
Pravastatin, beta-blockers, anti-diabetic sulfonylurea drugs such as
Glucotrol (glipizide) and Micronase (glyburide), and the anti-hypertension
drug Clonidine."
-
Cellular Nutrition for Vitality and Longevity - Life Extension Magazine,
4/00
-
How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine,
4/00
-
Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99
-
Nutrient Depletion Checklist - Nutrition Science News, 8/99
-
Co-Q10 Energizes the Heart and Brain - Nutrition Science News, 7/99
-
Co-Q10 and Cancer - Nutrition Science News, 4/99
Abstracts:
-
Reducing exercise-induced muscular injury in kendo athletes with
supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 -
"Subjects in the CoQ10 group took 300 mg CoQ10 per d
for 20 d ... These results indicate that CoQ10 supplementation reduced
exercise-induced muscular injury in athletes"
-
Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated
postmenopausal breast cancer women with special reference to blood chemistry
profiles - Breast Cancer Res Treat. 2008 Apr 22 -
"Tamoxifen (TAM) ... TAM also has estrogenic
activity on liver and endometrium causing severe oxidative stress with
various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN)
are well-known potent antioxidants and protective agents against many
diseases including cancer ... A statistically significant alteration in
various blood chemistry parameters, such as serum total bilirubin (S. BIL),
serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate
transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid
(UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases
(LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group,
was favorably reverted back to near normal levels on combinatorial therapy
with CoRN"
-
Reducing exercise-induced muscular injury in kendo athletes with
supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 -
"These results indicate that CoQ10 supplementation
reduced exercise-induced muscular injury in athletes"
-
Effect of Co-enzyme Q10 and Alpha-Lipoic Acid on Response of Rabbit Urinary
Bladder to Repetitive Stimulation and In Vitro Ischemia - Urology. 2008
Feb 15 - "CoQ10 showed no protective effect.
alpha-LA resulted in increased contractile responses of the control bladder
and showed a moderate protective effect for all forms of stimulation. The
combination, however, showed a significantly greater increase in the
contraction of the control bladder and a greater protective effect than
alpha-LA alone"
-
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and
liver and muscle enzyme levels in hypercholesterolemic patients treated with
atorvastatin: A randomized double-blind study - Atherosclerosis. 2007
Aug 4 - "All patients showed definite
reductions of plasma CoQ10 levels in the placebo group, by 42%. All patients
supplemented with CoQ10 showed striking increases in plasma CoQ10 by 127%.
In conclusion atorvastatin definitely decreased plasma CoQ10 levels and
supplementation with CoQ10 increased their levels"
-
Effect of coenzyme Q10 administration on endothelial function and
extracellular superoxide dismutase in patients with ischaemic heart disease:
a double-blind, randomized controlled study - Eur Heart J. 2007 Jul 19 -
"endothelium-dependent (ED) vasodilation ...
improvements elicited by CoQ(10) supplementation were remarkable in subjects
presenting low initial endothelium-bound ecSOD and thus more prone to
oxidative stress ... The enhancement of peak VO(2) and of O(2) pulse is
likely due to the bioenergetic effect of CoQ(10); on the other end, the
improved VO(2) could also depend on the observed enhanced peripheral
endothelial function"
-
Coenzyme Q(10) in the treatment of hypertension: a meta-analysis of the
clinical trials - J Hum Hypertens. 2007 Feb 8 -
"We conclude that coenzyme Q(10) has
the potential in hypertensive patients to lower systolic blood pressure by
up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without
significant side effects"
-
Effect of coenzyme q10 on myopathic symptoms in patients treated with
statins - Am J Cardiol. 2007 May 15;99(10):1409-12 -
"coenzyme Q10 supplementation may
decrease muscle pain associated with statin treatment. Thus, coenzyme Q10
supplementation may offer an alternative to stopping treatment with these
vital drugs"
-
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the
clinical trials - J Hum Hypertens. 2007 Apr;21(4):297-306 -
"coenzyme Q10 has the potential in
hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and
diastolic blood pressure by up to 10 mm Hg without significant side effects"
- See
coenzyme Q10 products at iHerb.
-
Coenzyme Q10 and exercise training in chronic heart failure - Eur Heart
J. 2006 Aug 1 - "CoQ10 main effect
was: peak VO2+9%, EDDBA +38%, systolic wall thickening score index (SWTI) -
12%"
-
Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10
- Diabetes Res Clin Pract. 2006 Apr;72(1):100-3 -
"In our patient, after the
introduction of Coenzyme Q10 150 mg/day, there was a gradual improvement on
left ventricular function evaluated by echocardiography. The fractional
shortening (FS) and ejection fraction (EF) increased from 26 to 34% and from
49 to 64%, respectively. No side effects were noted. Three months after
CoQ10 discontinuation, the parameters of systolic function evaluated by
echocardiography decreased, suggesting that CoQ10 had a beneficial effect"
-
Clinical aspects of coenzyme Q10: an update - Curr Opin Clin Nutr Metab
Care. 2005 Nov;8(6):641-6 - "A
4-year follow-up on 10 Friedreich's Ataxia patients treated with coenzyme
Q10 and vitamin E showed a substantial improvement in cardiac and skeletal
muscle bioenergetics and heart function"
-
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at
Risk for Cardiovascular Disease and Stroke - Arch Neurol.
2004;61:889-892 -
"Even brief exposure to atorvastatin
causes a marked decrease in blood CoQ10 concentration. Widespread inhibition
of CoQ10 synthesis could explain the most commonly reported adverse effects
of statins, especially exercise intolerance, myalgia, and myoglobinuria"
- Combined effect of coenzyme Q(10) and fenofibrate on forearm
microcirculatory function in type 2 diabetes -
Atherosclerosis 2003 May;168(1):169-79 -
"CoQ did not change plasma isoprostanes,
but significantly lowered systolic blood
pressure and HbA(1c)"
-
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of
the Functional Decline - Archives of Neurology, 10/02 -
"Less disability developed in
subjects assigned to coenzyme Q10 than in those assigned to placebo, and the
benefit was greatest in subjects receiving the highest dosage"
-
Randomized, double-blind placebo-controlled trial of coenzyme Q10 in
patients with acute myocardial infarction - Cardiovasc Drugs Ther. 1998
Sep;12(4):347-53
- Progress on therapy of breast cancer with vitamin Q10 and the regression of
metastases - Biochem Biophys Res Commun 1995 Jul
6;212(1):172-7 -
"The numerous
metastases in the liver of a 44-year-old patient "disappeared," and no signs
of metastases were found elsewhere. A 49-year-old patient, on a dosage of
390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity
after six months, and her condition was excellent. A 75-year-old patient
with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed
no cancer in the tumor bed or metastases"
- Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in
isolated systolic hypertension - South Med J 2001
Nov;94(11):1112-7 -
"conducted a 12-week randomized,
double-blind, placebo-controlled trial with twice daily administration of 60
mg of oral CoQ ... The mean reduction in systolic blood pressure of the CoQ-treated
group was 17.8"
-
Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin
resistance in hypertensive patients with coronary artery disease - J Hum
Hypertens. 1999 Mar;13(3):203-8 -
"the following indices were reduced in the coenzyme Q10 group: systolic and
diastolic blood pressure, fasting and 2-h plasma insulin, glucose,
triglycerides, lipid peroxides, malondialdehyde and diene conjugates. The
following indices were increased: HDL-cholesterol, vitamins A, C, E and
beta-carotene ... treatment with coenzyme Q10 decreases blood pressure
possibly by decreasing oxidative stress and insulin response in patients
with known hypertension receiving conventional antihypertensive drugs"
-
Partial and complete regression of breast cancer in patients
in relation to dosage of coenzyme Q10 -
Biochem Biophys Res Commun 1994 Mar 30;199(3):1504-8 -
"Six of the 32 patients showed partial tumor regression. In one of these 6
cases, the dosage of CoQ10 was increased to 390 mg. In one month, the tumor
was no longer palpable and in another month, mammography confirmed the
absence of tumor. Encouraged, another case having a verified breast tumor,
after non-radical surgery and with verified residual tumor in the tumor bed
was then treated with 300 mg. CoQ10. After 3 months, the patient was in
excellent clinical condition and there was no residual tumor tissue"
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