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Home > Anti-aging Research > Coenzyme Q10.

Coenzyme Q10 (ubiquinone)

Specific Recommendations:

News & Research:

Insulin Resistance - Dr. Weil - "Supplements: ... Coenzyme Q10 ... Alpha-lipoic acid ... Magnesium ... Chromium"
Antioxidant has potential in the Alzheimer's fight - Science Daily, 12/14/11 - "When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down ... Simply put, that same "browning" process-known as oxidative stress-happens in the brain as Alzheimer's disease sets in ... an antioxidant can delay the onset of all the indicators of Alzheimer's disease, including cognitive decline. The researchers administered an antioxidant compound called MitoQ to mice genetically engineered to develop Alzheimer's. The results of their study were published in the Nov. 2 issue of the Journal of Neuroscience ... Oxidative stress is believed to cause neurons in the brain to die, resulting in Alzheimer's ... The brain consumes 20 percent of the oxygen in the body even though it only makes up 5 percent of the volume, so it's particularly susceptible to oxidative stress ... MitoQ selectively accumulates in the mitochondria" - Note: I couldn't find the ingredients but it sounds like a form of co-enzyme Q10. Here's the form I take: Jarrow Formulas, Ubiquinol QH-Absorb, 100 mg, 60 Softgels at iHerb
- Antipodean Pharmaceuticals - MitoQ Technology
CoQ10 may boost antioxidant defenses in people with atherosclerosis - Nutra USA, 10/28/11 - "A daily CoQ10 dose of 150 mg was associated with 29% lower levels of malondialdehyde (MDA - a reactive carbonyl compound and a well-established marker of oxidative stress) after eight weeks, compared with the placebo group ... In addition, after 12 weeks of supplementation, the CoQ10 supplement appeared to stimulate the body’s antioxidant defenses and levels of the antioxidant enzymes catalase and superoxide dismutase (SOD) were 230% and 78% higher than the placebo group, respectively ... blood levels increased of CoQ10 increased in the high dose group by 189% after 12 weeks, but no significant increases were observed in the 60 mg group" - [Abstract]
CoQ10 may reduce muscle damage during intensive exercise - Nutra USA, 10/27/11 - "Twenty ultra-runners participated in the study and were divided into two equal groups. One group received one 30 mg capsule of CoQ10 two days before the test, three 30 mg capsules the day before the test, and one capsule one hour before the test. The other group received placebo at the same time. The test involved a 50 km distance run across Europe’s highest road in the Sierra Nevada ... Results showed that the placebo group displayed a 100% increase in levels of 8-OHdG, which <i>“a sensitive indicator of DNA damage as a result of oxidative stress”,</i> said the researchers, compared with an increase of 37.5% in the runners taking the CoQ10 supplements ... The data also indicated that CoQ10 countered the over-expression of certain pro-inflammatory compounds after exercise ... a reduction in levels of creatinine in the urine was observed in the CoQ10 group, compared with the placebo group. Creatinine is produced from creatine and high levels are a marker of muscle break down (or kidney damage) ... CoQ10 supplementation reduces creatinine excretion and therefore decrease muscle damage during physical performance" - [Abstract]
Natural therapies: Cardiologists examine alternatives to halt high blood pressure - Science Daily, 8/30/11 - "The shining star among supplements is coenzyme Q10, an enzyme involved in energy production that also acts as an antioxidant. Patients with hypertension tend to have lower levels of the enzyme, and a meta-analysis -- an overarching analysis of past studies -- found that treatment with coenzyme Q10 supplements significantly reduced blood pressure ... Coenzyme Q10 has a pretty profound effect on blood pressure, but whenever research is based on a collection of other data you have to have some skepticism ... potassium helps lower blood pressure, and there is evidence that increasing the amount of potassium we get through the foods we eat could carry some of the same mild benefits as taking supplements" - See coenzyme Q10 products at iHerb and potassium products at iHerb.
Pine bark extract plus CoQ10 shows benefits for heart failure patients - Nutra USA, 6/23/11 - "12 weeks of daily supplementation with 350 milligrams of CoQ10 (Kaneka) and 105 milligrams of the branded pine bark extract Pycnogenol ... recruited 53 heart failure patients aged between 54 and 68 were randomly assigned to receive either the PycnoQ10 supplement or placebo for 12 weeks ... systolic and diastolic blood pressure decreased following the CoQ10-pine bark combination, from 139.2 to 133.2 mmHg and 82.3 to 77.3 mmHg, respectively. Systolic and diastolic blood pressure decreased from 140.3 to 139.5 mmHg and 83.4 to 81.2 mmHg, respectively, in the placebo group ... In addition to increases in the amount of blood pumped by the heart, the researchers also reported improvements in heart rate were also observed in the PycnoQ10 supplement group from 78.4 to 74.2 beats per minute, compared with a decrease from 79.1 to 78.4 in the placebo group" - [Abstract] - See Pine Bark/Pycnogenol products at iHerb and Jarrow Ubiquinol at iHerb.
CoQ10 may protect against obesity problems: Study - Nutra USA, 10/15/09 - "We propose, in view of our study, that CoQ10, when given orally, is able to target the liver tissue, and to lessen inflammatory stress associated with obesity in mice in this tissue, independent on any action on lipid peroxidation" - [Abstract]
CoQ10 may boost sperm quality: Study - Nutra USA, 6/16/09 - "randomly assigned them to receive a daily CoQ10 supplement (300 mg, Kaneka, Japan) or placebo for 26 weeks. This was followed by 30 weeks with no intervention ... The Tehran-based researchers reported a significant improvement in both sperm density and motility following supplements of the coenzyme. A positive association was also found with regards to sperm count. Further analysis showed an increase in the percent of normal forms of sperm" - [Abstract]
CoQ10 Improves Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape, 5/29/09 - "Study subjects were randomized to receive either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute improvement in FMD of 1% with CoQ10 supplementation may potentially translate to a 10-25% reduction in residual cardiovascular risk in these patients"
Taking Statins? Five Ways to Boost Your Energy - ABC News, 4/14/09 - "It's a cruel irony that if statins make patients more lethargic, it could impair their ability to exercise or make dietary changes that would help them address their high cholesterol ... some studies have found that patients' energy levels increased while using CoQ10 and statins together ... Try pomegranate juice or a small chunk of dark chocolate, both of which have beneficial antioxidants ... Skimping on sleep has been found to increase calcium deposit build-up in your arteries"
Statin study: Lower cholesterol, diminished joy of sex linked - USA Today, 3/5/09 - "In the study, sexual pleasure sank along with LDL levels ... Some studies have found that statins improve sexual function, probably because the pills can improve blood flow to the genital area, Golomb says. But she says the drugs also may reduce Coenzyme Q10, a nutrient that helps cells convert oxygen, blood and glucose into energy. "Orgasm is a high-energy activity," so losing the nutrient could weaken sexual pleasure, she says" - See Jarrow Ubiquinol at iHerb.
Statins' Adverse Effects Documented - Science Daily, 1/29/09 - "Coenzyme Q10 ("Q10") is a compound central to the process of making energy within mitochondria and quenching free radicals. However, statins lower Q10 levels because they work by blocking the pathway involved in cholesterol production – the same pathway by which Q10 is produced. Statins also reduce the blood cholesterol that transports Q10 and other fat-soluble antioxidants ... "The loss of Q10 leads to loss of cell energy and increased free radicals which, in turn, can further damage mitochondrial DNA," said Golomb, who explained that loss of Q10 may lead to a greater likelihood of symptoms arising from statins in patients with existing mitochondrial damage – since these people especially rely on ample Q10 to help bypass this damage" - My favorite is QH-Absorb by Jarrow.
Reduced CoQ10 shows superior bioavailability: SGTI study - Nutra USA, 1/21/09
Product Review: CoQ10 and Ubiquinol Supplements - consumerlab.com, 1/13/09
Wrinkle creams: Your guide to younger looking skin - CNN - "Coenzyme Q10 is a nutrient that helps regulate energy production in cells. Some studies have shown reduction in fine wrinkles around the eyes with no side effects"
CoQ10 bioavailability boost from soft gels: Study - Nutra USA, 1/12/09 - "Researchers from Canada’s KGK Synergize compared CoQ10 formulations from hard and soft gel capsules, and found the reduced form from the latter resulted in a 3.3-fold higher blood level of CoQ10 than the former ... formulated by Soft Gel Technologies" - See iHerb search of "Soft Gel Technologies". I'm sticking with QH-Absorb by Jarrow because I don't trust the NOW brand. I feel that it probably just hasn't been studied yet.
Coenzyme Q-10 Depletion Linked to Worse Heart Failure Outcomes - Medscape, 10/22/08 - "Low plasma concentration of coenzyme Q-10 is an independent predictor of reduced survival in patients with chronic heart failure"
New Health Drink? Chemist Goes Nano With CoQ10 - Science Daily, 7/24/08
CoQ10 may cut muscle injuries for athletes - Nutra USA, 5/5/08 - "The volunteers had daily training sessions of five and a half hours per day for six days during the intervention period. At day three and five of the six day training period, the researchers report that both groups experienced increased in serum creatine kinase activity and the concentration of myoglobin, but these increases were significantly lower in the group receiving the CoQ10 supplements ... Elevated levels of the enzyme are indicative of muscle damage and injury ... levels of lipid peroxide, a marker of oxidative stress, were also lower in the CoQ10 group after three and five days of training" - [Abstract]
Migraine Patients May Benefit From Magnesium or CoQ10 - Clinical Psychiatry News, 8/07 - "The most important supplement, according to Dr. Mauskop, is magnesium. “It's known that up to 50% of people with acute migraine have a magnesium deficiency. … It is much more effective to treat them with a product they're deficient in rather than using drugs,” ... Research has found that, for migraine, CoQ10 at 300 mg/day is effective, and that for Parkinson's disease 1,200 mg/day is effective"
Report: Has Your Coq10 Become Obsolete? - Life Extension Magazine, 1/07 - "scientists have demonstrated that the ubiquinol form of CoQ10 provides anti-aging effects that are far superior to those associated with the conventional ubiquinone form used by millions of Americans each day" - See Jarrow Ubiquinol at iHerb.
Novel Form Of Coq10 - Life Extension Magazine, 12/06
Coenzyme Q10 review - ConsumerLab.com, 10/16/06
More support for CoQ10’s benefits for heart health - Nutra USA, 9/12/06 - "the heart's functional capacity improved significantly by nine per cent, as measured by the peak volume of oxygen consumed (VO2), for the CoQ10 compared to placebo"
Report: Coq10'S New Benefits - Life Extension Magazine, 8/06
CoQ10 may protect against Alzheimer’s - Nutra USA, 4/24/06
Coenzyme Q10 for Migraine Prophylaxis - Clinical Psychiatry News, 3/06 - "150 mg of coenzyme Q10 each day ... The study's primary outcome measure was the percentage of patients who achieved a greater than 50% reduction in the number of days with migraine. A total of 61.3% of patients met that outcome measure by 3 months, and 93.5% had at least a 25% reduction"
CoQ10’s “Other” Health Benefits - Life Extension Magazine, 2/06 - "The latest findings suggest that, along with its heart-protective effects, CoQ10 may slow or improve some degenerative diseases, support cancer remission, counteract the toxic effects of chemotherapy, and decrease the incidence of migraine headaches. Additionally, recent findings indicate that coenzyme Q10 may have applications in promoting fertility, protecting auditory function, supporting longevity, boosting learning capability, sustaining muscle health and much more"
Coenzyme Q10 New Applications for Cancer Therapy - Life Extension Magazine, 10/05
Four powerhouse nutrients - Functional Foods and Nutraceuticals, 4/05 - "L-carnitine shuttles fuel into cells to be burned as energy; coenzyme Q10 sparks the energy within the cells; ribose is a component of adenosine triphosphate (ATP); and alpha-lipoic acid increases ATP levels"
Coenzyme Q10 Lessens Muscle-Related Side Effects in Patients on Statins - Doctor's Guide, 3/7/05 - "Patients with significant myopathy who are taking statin therapy have a significant decrease in myopathic pain after 30 days of supplementation with coenzyme Q10" - See iHerb or Vitacost coenzyme Q10 products.
The high five for hypertension - Functional Foods & Nutraceuticals, 12/04 - "Co-enzyme Q10 ... Omega-3 fatty acids ... Garlic ... L-arginine ... Calcium"
Innovative Research and Applications for CoQ10 - Life Extension Magazine, 8/04 - "biomedical researchers are discovering that CoQ10 shows promising effects against disorders as far-ranging as kidney failure, heart disease, muscular dystrophy, and macular degeneration"
Proprietary CoQ10 formulation demonstrates superior absorption - Nutra USA, 6/30/04
Atorvastatin Reduces Blood CoQ10 Levels - Medscape, 6/22/04 - "Even brief exposure to atorvastatin causes a marked decrease in blood CoQ10 concentration ... Widespread inhibition of CoQ10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria"
Coenzyme Q10 May Ward Off Migraine Attacks - Medscape, 4/29/04 - "migraine may be caused by a decrease in mitochondrial energy reserve ... 100 mg of CoQ10 three times a day ... Approximately 48% of those who took CoQ10 had a 50% response rate during the three-month study, while this occurred in about 14% of those taking a placebo"
Coenzyme Q10 & Fertility - Physician's Weekly, 4/5/04
Cardiologists Overlook Lifesaving Discovery - Life Extension Magazine, 2/04
Coenzyme Q10 May Play Positive Role in Treatment of Male Infertility - Medscape, 1/30/04 - "Patients underwent oral administration of CoQ10, 200 mg/day twice daily for six months ... After treatment, CoQ10 levels increased in seminal plasma; the mean value rising significantly from 42.0 ± 5.1 ng/mL at baseline to 127.1 ± 1.9 ng/mL after six months of CoQ10 administration"
Coenzyme Q10 review - ConsumerLab.com, 1/13/03 - "There was no detectable CoQ10 in one product, another had only 71% of its claimed amount, and a third exceeded its claimed amount by 75%"
Coenzyme Q10 Helps Sperm Movement - WebMD, 1/12/04 - "Researchers say coenzyme Q10 is known to be active in the testes and is an antioxidant that plays an important role in forming the membranes and other structures within cells by fighting the effects of oxidative stress ... researchers looked at the effects of daily oral supplementation with 200 mg of coenzyme Q10"
Reason for concern? - Wellness Insider, 11/25/03 - "Dr. Golomb feels the potential side effects of statins, which include liver dysfunction, muscle pain (rhabdomyolysis), and potentially, muscle breakdown, have been significantly downplayed. She also feels that statins, especially at higher doses, contribute to memory loss and to the depletion of coenzyme Q10, a naturally occurring antioxidant-like nutrient vital to the production of energy"
Water Soluble Form of Coenzyme Q10 Suggested for Migraine Prophylaxis - Doctor's Guide, 9/30/03 - "researchers used a new water-soluble form of coenzyme Q10 at 100 mg three times daily for migraine prophylaxis ... Of the Q10 group, 47.6% of the patients had a 50% response for attack frequency, compared to 14.3% for the placebo group, resulting in a therapeutic gain of about 33.3%"
Coenzyme Q10 Beneficial for People with Kidney Failure - New Hope Natural Media, 7/17/03
Guarding Your Gums? - Dr. Weil, 6/16/03 - "Periodontal disease is a chronic gum infection caused by bacteria in plaque ... Coenzyme Q10: Take 120 mg per day of a soft-gel form with meals ... young women who get less than 800 mg of calcium a day have double the risk of periodontal disease" - See iHerbor Vitacost coenzyme Q10 products.
What Should We Advise Our Patients About Taking Antioxidants? - J Clin Hypertens 5(3):231-233, 2003 via Medscape - "At least two randomized trials of the effects of coenzyme Q10 (another antioxidant) on blood pressure have been reported. In the first,[20] 59 treated hypertensives were randomized to either coenzyme Q10 (60 mg twice daily) or vitamin B (placebo); after 8 weeks, clinic blood pressure was 14/7 mm Hg lower in the treated group. In the second,[21] 83 patients with isolated systolic hypertension were treated with coenzyme Q10 (using the same dose as the earlier study) for 12 weeks. The mean reduction of blood pressure was 17.8/7.3 mm Hg"
Coenzyme Q10 Deficiency Associated with Genetic Coordination Disorder - New Hope Natural Media, 6/12/03
How To Prevent Breast Cancer Anti-Cancer Power of Coenzyme Q10 - Life Extension Magazine, 1/96
Coenzyme Q10 Improves High Blood Pressure - New Hope Natural Media, 1/9/03 - "recruited 83 people with a condition called isolated systolic hypertension (ISH), in which the higher blood pressure ... These people were assigned to take either 60 mg of CoQ10 twice daily or a placebo for 12 weeks ... The people taking CoQ10 had an 18-point (18 mm Hg) reduction in systolic blood pressure (from 165 to 147 mm Hg), compared with only a 2-point decline in the placebo group ... ISH is the most common type of high blood pressure in the United States"
The First Therapy Shown To Slow Progression of Parkinson's Disease - Life Extension Magazine, 1/03
Coenzyme Q10 Appears To Slow Parkinson's Disease Progression - Doctor's Guide, 11/6/02
Study Suggests Coenzyme Q10 Slows Functional Decline In Parkinson's Disease - Doctor's Guide, 10/15/02
Coenzyme Q10 May Slow Parkinson's - WebMD, 10/14/02 - "High doses of the popular supplement coenzyme Q10 helps slow the progression of Parkinson's disease in some patients by as much as half ... Their study, published in the Oct. 15 issue of Archives of Neurology, is the latest to examine the possible benefits of coenzyme Q10, a vitamin-like compound naturally produced in the body and used by cells to make energy and protect against cellular damage"
MEDLINE Abstracts: Antioxidants and the Aging Brain - Medscape, 9/27/02 - "Combinations of antioxidants might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and ubiquinone). Naturally-occurring compounds with antioxidant capacity are available and widely marketed (e.g. vitamin C, ubiquinone, lipoic acid, beta-carotene, creatine, melatonin, curcumin) and synthetic compounds are under development by industry" - Again, a broad spectrum of anti-oxidants, not just one or two.
CoQ10, the Wonder Nutrient - Vitacost, 9/6/02 - "It was found that the concentrations of CoQ10 were significantly decreased in both plasma and whole blood of asthmatic sufferers compared with that of the healthy volunteers. The researchers speculated that sub-optimal concentrations of CoQ10 may play a possible contribution in patients with asthma"
Dr. Julian M. Whitaker Petitions FDA to Include CoQ10 Use Recommendation in All Statin Drug Labeling - Life Extension Magazine, 8/02 - "On May 23, 2002, Dr. Julian M. Whitaker filed two citizens petitions with the Food and Drug Administration. The petitions call on the Commissioner of Food and Drugs to change the labeling of all HMG CoA reductase inhibitor drugs (the so-called statin drugs), and to issue a Medication Guide, warning consumers of the need to take coenzyme Q10 (CoQ10) whenever they take a statin drug"
Coenzyme Q10 Effective for Migraine Prevention - New Hope Natural Media, 7/18/02 - "In the new study, 31 migraine sufferers were given 150 mg of CoQ10 per day for three months. The average number of days per month on which participants experienced headaches was 60% lower during the last two months of CoQ10 treatment than during the month prior to treatment. In addition, the average number of migraine attacks per month decreased by 42% with CoQ10 ... Two other nutrients that play a role in intracellular energy production (magnesium and riboflavin) have also been shown to reduce the recurrence rate of migraines"
How CoQ10 Protects Brain Cells - Life Extension Magazine, 10/01 - "Newly published research suggests that CoQ10 can protect brain cells from neurotoxicity and excitotoxicity, while even powerful antioxidants cannot. CoQ10 proved highly effective, while simple antioxidants were ineffective, in protecting PC-12 cells (neuron-like rat adrenal cells commonly used in neurobiological research) from the excitotoxic effects of glutamate and from the Parkinson’s disease-like effects of the neurotoxin MPP+. L-deprenyl (the drug selegilene) also proved effective, though not as effective as CoQ10"
ACSM Conference Unveils Performance Enhancers - Nutrition Science News, 9/01 - "Researchers have found that coenzyme Q10 (Co-Q10 or ubiquinone) can lower blood pressure in hypertensive people"
CoQ10 Shows Promise In Slowing Progression Of Huntington's Disease - Intelihealth, 8/23/01
Coenzyme Q10 Improves Cardiac Function in Children with Dilated Cardiomyopathy - Doctor's Guide, 5/30/01
Bioenergetic Therapy for Aging - Life Extension Magazine, 2/01
Staying Young Forever, Putting new research findings into practice - Life Extension Foundation, 12/99
Patients With Hereditary Ataxia Show Improvement With CoQ10 (Ubiquinone) - Doctor's Guide, 4/10/01
Trial of Coenzyme Q10 in Isolated Systolic Hypertension - Medscape, South Med J 94(11):1112-1117, 2001 - "The mechanisms underlying essential hypertension remain uncertain. A causal role for insulin resistance has been suggested,[35] and high levels of plasma insulin have frequently been found in patients with high blood pressure"
How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine, 4/00
Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00 - "A large number of drugs deplete Coenzyme Q10. These include such widely used tricyclic antidepressants as Elavil (amitriptyline) and Tofranil (imipramine), the anti-psychotic drug Haloperidol, cholesterol-lowering statin drugs such as Lovastatin and Pravastatin, beta-blockers, anti-diabetic sulfonylurea drugs such as Glucotrol (glipizide) and Micronase (glyburide), and the anti-hypertension drug Clonidine."
Cellular Nutrition for Vitality and Longevity - Life Extension Magazine, 4/00
How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine, 4/00
Staying Young Forever, Putting new research findings into practice - Life Extension Foundation, 12/99
Nutrient Depletion Checklist - Nutrition Science News, 8/99
Co-Q10 Energizes the Heart and Brain - Nutrition Science News, 7/99
Co-Q10 and Cancer - Nutrition Science News, 4/99

Abstracts:

Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials - Atherosclerosis. 2011 Oct 25 - "Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction"
Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease - Atherosclerosis. 2011 Mar 31 - "Atorvastatin significantly decreased serum ubiquinol (731±238 to 547±219nmol/L, p=0.001), but rosuvastatin (680±233 to 668±299nmol/L, p=0.834) did not" - See Jarrow Formulas, Ubiquinol QH-Absorb, 100 mg, 60 Softgels at iHerb.
Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial - Atherosclerosis. 2011 Feb 17 - "Coronary artery disease (CAD) is associated with endothelial dysfunction and mitochondrial dysfunction (MD) ... brachial flow-mediated dilation (FMD) in patients with ischaemic LVSD (left ventricular ejection fraction <45%) ... In patients with ischaemic LVSD, 8weeks supplement of CoQ improved mitochondrial function and FMD; and the improvement of FMD correlated with the change in mitochondrial function, suggesting that CoQ improved endothelial function via reversal of mitochondrial dysfunction in patients with ischaemic LVSD"
Improved Survival in Patients with End-stage Cancer Treated with Coenzyme Q(10) and Other Antioxidants: a Pilot Study - J Int Med Res. 2009;37(6):1961-1971 - "This pilot study evaluated the survival of patients with end-stage cancer who received supplements of coenzyme Q(10) and a mixture of other antioxidants (e.g. vitamin C, selenium, folic acid and beta-carotene) ... Median predicted survival was 12 months (range 3 - 29 months), whereas median actual survival was 17 months (1 - 120 months), which is > 40% longer than the median predicted survival. Mean actual survival was 28.8 months versus 11.9 months for mean predicted survival. Ten patients (24%) survived for less time than predicted, whereas 31 (76%) survived for longer. Treatments were very well tolerated with few adverse effects"
Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart - Mech Ageing Dev. 2009 Nov 27 - "Age-related changes in cardiomyocytes reduce the capacity to recover from acute injury or to adapt during chronic disease in advanced age. N-6 Polyunsaturated fatty acids (n-6PUFA) lead to higher lipid peroxidation during aging than the less oxidizable monounsaturated fatty acids (MUFA); and coenzyme Q (CoQ)-supplemented n-6PUFA lengthens the lifespan and reduces peroxidation in comparison to non-supplemented n-6PUFA ... The lowest hydroperoxide levels for aged animals were found for n-6 PUFA+CoQ, which also showed lower concentrations than did n-6 PUFA ... The results suggest that MUFA can protect mitochondria from age-related changes, and that CoQ supplementation to n-6 PUFA partially resembles MUFA benefits. Moreover, under our experimental conditions, lipid-derived oxidative damage appears to be more important than the pure protein-derived oxidative damage during aging"
Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice - Biochem Pharmacol. 2009 Dec 1;78(11):1391-400 - "CoQ10 supplementation decreased the global hepatic mRNA expression of inflammatory and metabolic stresses markers without changing obesity and tissue lipid peroxides compared to HFF mice"
Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men - J Urol. 2009 Jul;182(1):237-48 - "were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase ... Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters"
Coenzyme Q(10) An Independent Predictor of Mortality in Chronic Heart Failure - J Am Coll Cardiol. 2008 Oct 28;52(18):1435-1441 - "Plasma CoQ(10) concentration was an independent predictor of mortality in this cohort. The CoQ(10) deficiency might be detrimental to the long-term prognosis of CHF, and there is a rationale for controlled intervention studies with CoQ(10)"
Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 - "Subjects in the CoQ10 group took 300 mg CoQ10 per d for 20 d ... These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes"
Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles - Breast Cancer Res Treat. 2008 Apr 22 - "Tamoxifen (TAM) ... TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer ... A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN"
Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 - "These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes"
Effect of Co-enzyme Q10 and Alpha-Lipoic Acid on Response of Rabbit Urinary Bladder to Repetitive Stimulation and In Vitro Ischemia - Urology. 2008 Feb 15 - "CoQ10 showed no protective effect. alpha-LA resulted in increased contractile responses of the control bladder and showed a moderate protective effect for all forms of stimulation. The combination, however, showed a significantly greater increase in the contraction of the control bladder and a greater protective effect than alpha-LA alone"
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: A randomized double-blind study - Atherosclerosis. 2007 Aug 4 - "All patients showed definite reductions of plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion atorvastatin definitely decreased plasma CoQ10 levels and supplementation with CoQ10 increased their levels"
Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study - Eur Heart J. 2007 Jul 19 - "endothelium-dependent (ED) vasodilation ... improvements elicited by CoQ(10) supplementation were remarkable in subjects presenting low initial endothelium-bound ecSOD and thus more prone to oxidative stress ... The enhancement of peak VO(2) and of O(2) pulse is likely due to the bioenergetic effect of CoQ(10); on the other end, the improved VO(2) could also depend on the observed enhanced peripheral endothelial function"
Coenzyme Q(10) in the treatment of hypertension: a meta-analysis of the clinical trials - J Hum Hypertens. 2007 Feb 8 - "We conclude that coenzyme Q(10) has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects"
Effect of coenzyme q10 on myopathic symptoms in patients treated with statins - Am J Cardiol. 2007 May 15;99(10):1409-12 - "coenzyme Q10 supplementation may decrease muscle pain associated with statin treatment. Thus, coenzyme Q10 supplementation may offer an alternative to stopping treatment with these vital drugs"
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials - J Hum Hypertens. 2007 Apr;21(4):297-306 - "coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects" - See coenzyme Q10 products at iHerb.
Coenzyme Q10 and exercise training in chronic heart failure - Eur Heart J. 2006 Aug 1 - "CoQ10 main effect was: peak VO2+9%, EDDBA +38%, systolic wall thickening score index (SWTI) - 12%"
Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10 - Diabetes Res Clin Pract. 2006 Apr;72(1):100-3 - "In our patient, after the introduction of Coenzyme Q10 150 mg/day, there was a gradual improvement on left ventricular function evaluated by echocardiography. The fractional shortening (FS) and ejection fraction (EF) increased from 26 to 34% and from 49 to 64%, respectively. No side effects were noted. Three months after CoQ10 discontinuation, the parameters of systolic function evaluated by echocardiography decreased, suggesting that CoQ10 had a beneficial effect"
Clinical aspects of coenzyme Q10: an update - Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):641-6 - "A 4-year follow-up on 10 Friedreich's Ataxia patients treated with coenzyme Q10 and vitamin E showed a substantial improvement in cardiac and skeletal muscle bioenergetics and heart function"
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at Risk for Cardiovascular Disease and Stroke - Arch Neurol. 2004;61:889-892 - "Even brief exposure to atorvastatin causes a marked decrease in blood CoQ10 concentration. Widespread inhibition of CoQ10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria"
Combined effect of coenzyme Q(10) and fenofibrate on forearm microcirculatory function in type 2 diabetes - Atherosclerosis 2003 May;168(1):169-79 - "CoQ did not change plasma isoprostanes, but significantly lowered systolic blood pressure and HbA(1c)"
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline - Archives of Neurology, 10/02 - "Less disability developed in subjects assigned to coenzyme Q10 than in those assigned to placebo, and the benefit was greatest in subjects receiving the highest dosage"
Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction - Cardiovasc Drugs Ther. 1998 Sep;12(4):347-53
Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 - "The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases"
Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension - South Med J 2001 Nov;94(11):1112-7 - "conducted a 12-week randomized, double-blind, placebo-controlled trial with twice daily administration of 60 mg of oral CoQ ... The mean reduction in systolic blood pressure of the CoQ-treated group was 17.8"
Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease - J Hum Hypertens. 1999 Mar;13(3):203-8 - "the following indices were reduced in the coenzyme Q10 group: systolic and diastolic blood pressure, fasting and 2-h plasma insulin, glucose, triglycerides, lipid peroxides, malondialdehyde and diene conjugates. The following indices were increased: HDL-cholesterol, vitamins A, C, E and beta-carotene ... treatment with coenzyme Q10 decreases blood pressure possibly by decreasing oxidative stress and insulin response in patients with known hypertension receiving conventional antihypertensive drugs"
Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10 - Biochem Biophys Res Commun 1994 Mar 30;199(3):1504-8 - "Six of the 32 patients showed partial tumor regression. In one of these 6 cases, the dosage of CoQ10 was increased to 390 mg. In one month, the tumor was no longer palpable and in another month, mammography confirmed the absence of tumor. Encouraged, another case having a verified breast tumor, after non-radical surgery and with verified residual tumor in the tumor bed was then treated with 300 mg. CoQ10. After 3 months, the patient was in excellent clinical condition and there was no residual tumor tissue"

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