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Recent Longevity News for the week ending 4/27/16

Latest Data: Calcium Supplements Not Associated With CVD - Medscape, 4/22/16 - "There were no associations between use of calcium supplements and risk of incident hospital admission with ischemic heart disease, any cardiovascular event, or death following either admission category" - Note:  It's like Actos and bladder cancer, the studies have been going back and forth for years.

Metformin Active in Reducing Colorectal Polyp Recurrence - Medscape, 4/22/16 - "they took patients who underwent resection of polyps/adenomas, and they randomly assigned them to receive a placebo or low-dose metformin, 250 mg daily. The treatment lasted for 1 year ... there was a significant reduction in the number of polyps/adenomas in the metformin-treated group: 38% of patients had recurrent adenomas compared with 57% in the placebo group" - See metformin at IAS.

Study: Heavy Pot Users Face As Many Midlife Troubles As Those Dependent on Alcohol - CNS News, 3/19/16 - "Researchers found that regular cannabis smokers “ended up in a lower social class than their parents, with lower-paying, less skilled and less prestigious jobs than those who were not regular cannabis smokers." ... These regular and persistent users also experienced more financial, work-related and relationship difficulties, which worsened as the number of years of regular cannabis use progressed ... Regular long-term users also had more antisocial behaviors at work, such as stealing money or lying to get a job, and experienced more relationship problems, such as intimate partner violence and controlling abuse ... Our data indicate that persistent cannabis users constitute a burden on families, communities, and national social-welfare systems"

Beyond Resveratrol: The Anti-Aging NAD Fad - Scientific American, 3/11/15 - "A prominent theory of aging holds that decaying of mitochondria is a key driver of aging. While it's not clear why our mitochondria fade as we age, evidence suggests that it leads to everything from heart failure to neurodegeneration, as well as the complete absence of zipping around the supper table ... NAD boosters might work synergistically with supplements like resveratrol to help reinvigorate mitochondria and ward off diseases of aging. Elysium is banking on this potential synergy—its NR-containing supplement includes a resveratrol-like substance called pterostilbene (pronounced tero-STILL-bean), which is found in blueberries and grapes ... Why pterostilbene instead of resveratrol? ... While resveratrol has hogged the anti-aging spotlight over the past decade, unsung researchers in places like Oxford, Miss., have quietly shown that pterostilbene is a kind of extra-potent version of resveratrol. The pterostilbene molecule is nearly identical to resveratrol's except for a couple of differences that make it more "bioavailable" (animal studies indicate that about four times as much ingested pterostilbene gets into the bloodstream as resveratrol). Test-tube and rodent studies also suggest that pterostilbene is more potent than resveratrol when it comes to improving brain function, warding off various kinds of cancer and preventing heart disease." - Note: This was a year old article that showed up on my Facebook. I read some of the reviews on Amazon. Nothing gets my goat more that people who think something that delays aging has to give you a buzz such as caffeine. That said, some of the reviews for nicotinamide riboside said it negatively affected their sleep and made them for fatigued and depressed. The negative reviews for Niagen seems to be from those that think it has to give you a buzz (err!!).  I'm sticking with this for now: Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.  Also see Niagen at Amazon.com.

Diabetes drug, metformin, lowers risk of heart disease deaths better than sulfonylureas - Science Daily, 4/20/16 - "A new analysis of 204 studies involving more than 1.4 million people suggests that metformin, the most frequently prescribed stand-alone drug for type 2 diabetes, reduces the relative risk of a patient dying from heart disease by about 30 to 40 percent compared to its closest competitor drug, sulfonylurea ... Among other findings, the new review revealed that DPP-4 inhibitors, a class of anti-diabetic drugs that were very new at the time of the 2011 review, were clearly less effective at lowering blood sugar levels compared to metformin and sulfonylureas" - See metformin at IAS.

Eating dark chocolate as a daily snack could help boost athletic performance - Science Daily, 4/19/16 - "dark chocolate provides similar benefits to beetroot juice, now taken regularly by elite athletes after studies showed it can improve performance. "Beetroot juice is rich in nitrates, which are converted to nitric oxide in the body. This dilates blood vessels and reduces oxygen consumption -- allowing athletes to go further for longer," ... after eating dark chocolate, the riders used less oxygen when cycling at a moderate pace and also covered more distance in a two-minute flat-out time trial" - See Ghirardelli Chocolate Intense Dark Squares, Midnight Reverie, 4.12 oz., 86% Cacao (Pack of 4) at Amazon.com.

Abstracts from this week:

Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet - Nutrients. 2016 Apr 20;8(4) - "oral resveratrol appears to exert anti-OA effects in a mouse model of HFD-induced OA, thereby highlighting the potential preventive and therapeutic value of administering resveratrol for obesity-associated OA" - See Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.

Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome - Neurobiol Aging. 2016 May;41:73-85 - "Aging has been related to diminished cognitive function, which could be a result of ineffective synaptic function ... We found significant reduction of 15 synaptic plasma membrane proteins in aging brains including fodrin-α, synaptopodin, postsynaptic density protein 95, synaptic vesicle glycoprotein 2B, synaptosomal-associated protein 25, synaptosomal-associated protein-α, N-methyl-D-aspartate receptor subunit epsilon-2 precursor, AMPA2, AP2, VGluT1, munc18-1, dynamin-1, vesicle-associated membrane protein 2, rab3A, and EAAT1, most of which are involved in synaptic transmission. Notably, the first 9 proteins were further reduced when brain DHA was depleted by diet, indicating that DHA plays an important role in sustaining these synaptic proteins downregulated during aging. Reduction of 2 of these proteins was reversed by raising the brain DHA level by supplementing aged animals with an omega-3 fatty acid sufficient diet for 2 months. The recognition memory compromised in DHA-depleted animals was also improved" - See Jarrow Max DHA at Amazon.com.

Association Between Protein Intake and Mortality in Hypertensive Patients Without Chronic Kidney Disease in the OLD-HTA Cohort - Hypertension. 2016 Apr 18 - "A total of 1128 hypertensive patients were followed according to tertile of protein intake adjusted for ideal body weight: <0.70, 0.70 to 0.93, and >0.93 g/kg ... 10 years of follow-up ... patients in the second and third tertiles of protein intake had a decreased risk of all-cause death (hazard ratio [95% confidence interval], 0.71 [0.56-0.91]) and cardiovascular death (0.72 [0.54-0.96]), but not of stroke death (0.72 [0.41-1.28]) in comparison to patients in the low protein intake tertile. Normal-high protein intake was associated with a better outcome in a subset of the population ... Hypertensive patients having a protein intake >0.7 g/kg ideal body weight, particularly those at low risk, had lower all-cause and cardiovascular mortality rates. Physicians may encourage hypertensive patients to have normal or high protein diet in addition to low salt consumption, moderate alcohol consumption, and regular physical activity"

Flavanol-rich chocolate acutely improves arterial function and working memory performance counteracting the effects of sleep deprivation in healthy individuals - J Hypertens. 2016 Apr 14 - "Flavanol-rich chocolate counteracted vascular impairment after sleep deprivation and restored working memory performance. Improvement in cognitive performance could be because of the effects of cocoa flavonoids on blood pressure and peripheral and central blood flow" - See Ghirardelli Chocolate Intense Dark Squares, Midnight Reverie, 4.12 oz., 86% Cacao (Pack of 4) at Amazon.com.

Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation - Biochem Biophys Res Commun. 2016 Apr 14 - "The progressive degeneration and ossification of articular chondrocytes are main symptoms in the pathogenesis of osteoarthritis (OA). Several flavonoids may provide an adjunctive alternative for the management of moderate OA in humans. Rutin, a natural flavone derivative (quercetin-3-rhamnosylglucoside), is well known for its potent anti-inflammatory and anti-oxidant properties against oxidative stress ... The findings of these studies suggested the potential involvement of SIRT1 in the pathogenesis of OA, and indicated that rutin is a possible therapeutic option for OA" - See rutin at Amazon.com.

Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Increase Muscle Strength and Function in Frail Elderly Adults in a Randomized Controlled Trial - J Nutr. 2016 Apr 13 - "Sarcopenia, the loss of skeletal muscle mass, strength, and function, is common in elderly individuals but difficult to treat ... The first group received a daily L-leucine (1.2 g) and cholecalciferol (20 μg)-enriched supplement with 6 g medium-chain triglycerides (TGs) (MCTs) (LD + MCT); the second group received the same leucine and cholecalciferol-enriched supplement with 6 g long-chain TGs (LD + LCT); and the third group did not receive any supplements (control). The supplement and oils were taken at dinner, and changes in muscle mass, strength, and function were monitored ... After 3 mo, participants in the LD + MCT group had a 13.1% increase in right-hand grip strength (1.2 ± 1.0 kg,P< 0.01), a 12.5% increase in walking speed (0.078 ± 0.080 m/s,P< 0.05), a 68.2% increase in a 10-s leg open-and-close test performance (2.31 ± 1.68n/10 s,P< 0.001), and a 28.2% increase in peak expiratory flow (53 ± 59 L/min,P< 0.01). No significant improvements in muscle mass, strength, or function were observed in the LD + LCT or control groups" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram).

Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals - FASEB Journal Apr 2016 - "CurcuWIN®, a novel curcumin formulation containing 20% curcuminoids (CUR), resulted in 45.9 fold greater absorption over standard curcumin ... Fifty-nine moderately trained men (n=30; 21±2 years; 173.8±20.0 cm; 79.4±11.0 kg) and women (n=29; 21±2 years; 164.9±6.5 cm; 60.1±8.0 kg) were randomly assigned to ingest 50 mg CUR (in the form of 250 mg CurcuWIN®), 200 mg CUR (in the form of 1000 mg CurcuWIN®), or placebo (PLA) for eight weeks ... These data demonstrate 200mg CUR improves FMD (endothelial function) in healthy young subjects. Further, in those with baseline FMD ≤7% FMD (at risk) 50mg CUR and 200mg CUR improves endothelial function. Given every 1% increase in FMD reduces cardiovascular disease risk by 9–17%; further research in clinical populations is recommended to clarify the true nature of the effect and potential mechanism(s)" - [Nutra USA] - See CurcuWIN® at Amazon.com.

Per meal dose and frequency of protein consumption is associated with lean mass and muscle performance - Clin Nutr. 2016 Apr 7 - "We found that more frequent consumption of meals containing between 30 and 45 g protein/meal produced the greatest association with leg lean mass and strength. Thus, the consumption of 1-2 daily meals with protein content from 30 to 45 g may be an important strategy for increasing and/or maintaining lean body mass and muscle strength with aging" 

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