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Recent Longevity News for the week ending
really all that bad for you? - CNET, 8/25/14 - It's a 3 minute video.
glutamate intake is inversely related to the risk of hyperglycemia - Clin
Nutr. 2013 Nov 1 - "We followed 1056 healthy adults aged
20 years and older from 2002 to 2007. Dietary data were collected during home
visits using a 3-day food record and a food frequency questionnaire ... The
highest quartile of MSG intake was associated with a lower risk of incident
hyperglycemia, even after adjustment for a number of covariates, including
dietary patterns. Comparing the highest with the lowest quartiles of MSG intake,
the odds ratio (OR) for hyperglycemia was 0.30 (95% CI 0.13-0.66). There was a
linear inverse association between MSG intake and change in blood glucose"
pomegranate drug to stem Alzheimer's, Parkinson's - Science Daily, 8/22/14 -
"The onset of Alzheimer's
disease can be slowed and some of its symptoms curbed by a natural compound
that is found in pomegranate. Also, the
painful inflammation that accompanies illnesses such as rheumatoid
Parkinson's disease could be reduced ... punicalagin, which is a polyphenol
-- a form of chemical compound -- found in pomegranate fruit, can inhibit
inflammation in specialised brain cells known as micrologia. This inflammation
leads to the destruction of more and more brain cells, making the condition of
Alzheimer's sufferers progressively worse ... we do know that regular intake and
regular consumption of pomegranate has a lot of health benefits -- including
prevention of neuro-inflammation related to dementia" - See
pomegranate extract at Amazon.com.
Abstracts from this week:
multi-nutrient enriched diet enhances hippocampal cholinergic transmission in
aged rats - Neurobiol Aging. 2014 Jul 24 - "Fortasyn
Connect (FC) is a specific nutrient combination designed to target synaptic
dysfunction in Alzheimer's disease by
providing neuronal membrane precursors and other supportive nutrients ... the FC
diet enhances hippocampal cholinergic neurotransmission in aged rats and suggest
that this effect is mediated by enhanced synaptic membrane formation. These data
provide further insight into cellular and molecular mechanisms by which FC may
support memory processes in Alzheimer's disease"
Souvenaid - Wikipedia - "Souvenaid was
developed by Advanced Medical Nutrition division of Nutricia and
contains a patented combination of nutrients, referred to under the
trademark Fortasyn Connect™. Souvenaid was designed to support
synapse formation and function in early Alzheimer’s disease ...
Composition ... Eicospentaenoic acid, 300 mg ... Docosahexaenoic
acid, 1200 mg ... Phospholipids 106 mg ... Choline, 400 mg ...
Uridine monophosphate, 625 mg ...
Vitamin E (alpha-tocopherol equivalents), 40 mg ... Selenium, 60 µg
... Vitamin B12, 3 µg ... Vitamin B6, 1 mg ... Folic acid, 400 µg"
uridine at Amazon.com.
Most health conscious people are probably already taking the other
A1c, comorbid conditions and all-cause mortality in older patients with
diabetes: A retrospective 9-year cohort study - Diabetes Res Clin Pract.
2014 Jul 29 - "In our patient population,
HbA1c scores<6.4% have significantly higher
N-Acetylcysteine administration prevents nonthyroidal illness syndrome in
patients with acute myocardial infarction: a randomized clinical trial - J
Clin Endocrinol Metab. 2014 Aug 22 - "The acute phase of
the non-thyroidal syndrome (NTIS) is characterized by low triiodothyronine (T3)
and high reverse T3 (rT3) levels, affecting up to 75% of critically ill
patients. Oxidative stress has been implicated as a causative factor of the
disturbed peripheral thyroid hormone metabolism ...
NAC administration prevents the derangement in
thyroid hormone concentrations commonly occurring in the acute phase of acute
myocardial infarction, indicating that oxidative stress is involved in the NTIS
pathophysiology" - See
n-acetyl cysteine at Amazon.com.
Acid Prevents High Glucose-induced Apoptosis in Human Brain Pericytes -
Biochem Biophys Res Commun. 2014 Aug 21 - "High glucose
concentrations due to diabetes increase apoptosis of vascular pericytes,
impairing vascular regulation and weakening vessels, especially in brain and
retina. We sought to determine whether vitamin C,
or ascorbic acid, could prevent such high glucose-induced increases in pericyte
apoptosis ... the prevention of apoptosis by ascorbate may involve effects
beyond its function as an antioxidant" - See
vitamin C products at Amazon.com.
and neuroprotective effects of chlorogenic acid - Nutr Neurosci. 2014 Aug 17
- "chlorogenic acid (CGA) ... A literature search was
conducted using PubMed ... Recent research suggests that dietary consumption of
CGA could produce a wide range of health benefits and physiological effects.
There is also mounting evidence that the consumption of polyphenols, including
CGA, in the diet could reduce the risk of developing neurodegenerative
conditions" - See
green coffee bean extract at Amazon.com.
Lipid-Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A
Randomized, Double-Blind, Placebo-Controlled Trial - Phytother Res. 2014
Aug 6 - "Sixty-five patients were randomized into
two groups; 33 patients taking curcumin extract capsule (630 mg thrice
daily) and 32 patients taking a placebo capsule thrice daily for 12 weeks.
At 12 weeks after the curcumin extract consumption, the level of
high-density lipoprotein cholesterol (HDL-C) significantly increased from
40.96 ± 8.59 to 43.76 ± 2.79 mg/dL (p < 0.05), and the level of
lipoprotein cholesterol (LDL) was significantly reduced (120.55 ± 36.81 to
106.51 ± 25.02 mg/dL, p < 0.05). The triglyceride-lowering effect, a
reduction of 65 mg/dL, was also found in this study" - See
curcumin products at Amazon.com.
Health Focus (Tinnitus):
Coffee May Keep Your Ears From Ringing - WebMD, 8/8/14 -
"Women who consumed
less than 150 milligrams (mg) a day of caffeine (found in about one-and-a-half
8-ounce cups of coffee) were 15 percent more likely to develop tinnitus than
those who consumed 450 mg to 599 mg a day of caffeine, the investigators found
... We know that caffeine stimulates the central nervous system, and previous
research has demonstrated that caffeine has a direct effect on the inner ear in
both bench science and animal studies"
- Improvement in
symptoms and cochlear flow with pycnogenol in patients with Meniere's
disease and tinnitus - Minerva Med. 2014 Jun;105(3):245-54 -
"All subjects were managed with the best available
management (BM); one group used the supplement Pycnogenol (150 mg/day) ...
There was a more significant improvement in all registry items at 3 and 6
months in the Pycnogenol group (P<0.05). The number of lost working days was
lower in the Pycnogenol group. At 3 months, 45.4% of subjects using
Pycnogenol were completely asymptomatic in comparison with 23.07% of
controls. At 6 months 87.3% of the Pycnogenol subjects were asymptomatic
compared with 34.6% of controls. Cochlear flow velocity was significantly
better (higher flow, higher diastolic component) in the Pycnogenol group
(P<0.05). The subjective tinnitus scale decreased in both groups (P<0.05);
the decrease was more significant in Pycnogenol subjects (P<0.05) at 3 and 6
months" - See
Pycnogenol at Amazon.com.
Preventing noise-induced hearing loss, tinnitus in soldiers - Science
Daily, 9/6/12 - "Antioxidants, dietary supplements
and high-tech brain imaging are among some of the novel strategies that may
help detect, treat and even prevent noise-induced hearing loss and tinnitus
among American troops ... Noise-induced hearing loss doesn't just impact a
person's ability to hear; it can cause balance issues, make it difficult to
sleep and communicate, and even raise the risk for heart disease by
increasing a person's blood pressure, lipids and blood sugar ... Dr. Seidman
will discuss the use of nutraceuticals, such as acetyl-l-carnitine, alpha
lipoic acid and resveratrol ... a nutraceutical with a resveratrol-based
component may possibly hold the potential to not only prevent, but reverse
hearing loss in certain circumstances for soldiers. This research is based
on animal models, but will soon be tested with humans" - See
resveratrol products at Amazon.com.
Pine bark extract may relieve tinnitus symptoms: Study - Nutra USA,
10/14/10 - "Impaired blood flow to the ear is a
common cause for tinnitus, a disturbing and very debilitating condition that
can considerably impact overall health and quality of life ... both doses of
Pycnogenol improved blood systolic and diastolic blood flow velocities from
14.3 and 4.22 cm/sec in the 100 mg per day group to 21.2 and 8.23 cm/sec,
and from 13.2 and 3.2 cm/sec in the 150 mg per day group to 24.3 and 12.5
cm/sec, respectively ... In addition, the researchers used a Subjective
Tinnitus Scale (STS) to evaluate the symptoms of tinnitus. Results showed a
decrease from an average of 8.8 in the pine bark groups to 5.2 and 3.3 in
the low and high dose groups, respectively" - See
Pycnogenol at Amazon.com.
- Zinc Reduces the
Severity of Tinnitus - New Hope Natural Media, 4/17/03 -
"The current study examined the prevalence of
zinc deficiency and the effect of zinc therapy in people with tinnitus.
Forty-one people with tinnitus participated in the study, and more than 31%
of them were found to have zinc deficiency. All of the participants were
randomly assigned to receive either 50 mg of zinc or placebo daily. At the
end of two months, 46% of the people in the zinc group had clinical
improvement, defined as a ten-decibel or greater decrease in loudness of
tinnitus" - See
iHerb zinc products. Also, see my zinc page
for reasons you should not take it without copper.
Scientists find mechanism that causes noise-induced tinnitus and drug that
can prevent it - Science Daily, 5/27/13 - "An
epilepsy drug shows promise in an animal model at preventing tinnitus from
developing after exposure to loud noise ... mice that were treated with
retigabine immediately after noise exposure did not develop tinnitus"
New effective treatment for tinnitus? - Science Daily, 5/28/12
is Associated With Increase in the Intima-Media Thickness of Carotid
Arteries in Japanese Undergoing a Brain Screening Program - Am J Med
Sci. 2011 Jun 2 - "Increased intima-media thickness
was observed in 53.1% overall (in 57.6% of men and in 46.2% of women), with
significant associations with tinnitus (odds ratio, 1.62; 95% confidence
interval, 1.19-2.22), age, male gender and hypertension. The tinnitus link
persisted after adjustment for the confounding factors"
Prolonged mobile phone use may be linked to tinnitus - Science Daily,
7/20/10 - "Regularly using a mobile phone for at
least four years seems to be associated with a doubling in the risk of
developing chronic tinnitus"
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