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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Home > Anti-aging Research > Statins > Lipitor
(atorvastatin)
Lipitor (atorvastatin)
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Where to purchase:
-
SuperSaverMeds.com
- OffshoreRX.com
 - Free shipping on orders over $250.
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EZMedz
News & Research:
-
Top-selling Cholesterol Drug Does Little For Women, Study Suggests -
Science Daily, 9/17/08 - "Not one of the studies
that included women with a mixture of risk factors for heart attacks
provided statistically significant support for prescribing Lipitor or other
statins to protect against cardiovascular problems. Pfizer’s claims of
clinical proof that Lipitor reduces risk of heart attack in patients with
multiple risk factors for heart disease does not appear to be scientifically
supported for large segments of the female population ... Lipitor’s
advertising repeatedly fails to report that clinical trials were
statistically significant for men but not for women. Unqualified advertising
claims of protection against heart attacks may therefore be misleading"
-
Statins Lower Risk of Recurrent Stroke in Both Elderly, Younger Patients
- Doctor's Guide, 9/10/08 - "Within each group,
about half of the people received atorvastatin and about half received a
placebo. The participants were then followed for an average of 4.5 years ...
Low-density lipoprotein (LDL) cholesterol was lowered by an average of 61
points during the study for the elderly group, and by 59 points for the
younger group. Those in the younger group reduced their risk for another
stroke by 26% and the elderly group reduced their risk by 10%"
-
Prostate Cancer Can Be Halted With Anti-inflammatory And Statin Used In
Tandem, Study Suggests - Science Daily, 4/14/08 -
"A combination of low doses of Lipitor and Celebrex
had a more potent inhibiting effect on the formation of later stage tumors
than a higher dose of either agent alone ... The results from our study
indicate that a combination of Lipitor and Celebrex may be an effective
strategy for the prevention of prostate cancer progression from the first to
the second stage"
-
Lipitor Linked to Bleeding After Stroke - WebMD, 12/12/07
-
Atorvastatin Helps Protect Kidneys in SPARCL Patients - Doctor's Guide,
11/12/07 - "Treatment of stroke patients with
atorvastatin can preserve kidney function in patients with or without
chronic kidney disease, metabolic syndrome or type 2 diabetes"
-
Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's
Weekly Article, 10/15/07 - "there appears to be a
strong reduction in dementia and Parkinson’s disease incidence attributed to
the use of simvastatin, a cholesterol lowering drug. The researchers also
observed a moderate reduction in incidence of these conditions with
atorvastatin, another cholesterol-lowering drug"
-
Cholesterol Drug Change May Be Risky - WebMD, 9/5/07 -
"Compared with the patients who remained on Lipitor,
those who switched to simvastatin were 43% more likely to suffer from a
major cardiovascular event such as heart attack or stroke. They were twice
as likely to suffer strokes, and 36% more likely to have heart attacks"
-
Zocor vs. Alzheimer's and Parkinson's - WebMD, 7/18/07 -
"In patients over age 64, those who took Zocor were
54% less likely to get Alzheimer's disease and 49% less likely to get
Parkinson's disease than were matched patients not taking statin drugs ...
Those who took Lipitor were 9% less likely to get Alzheimer's disease"
- See simvastatin at OffshoreRX.com.
-
Older Patients Reap Positive Benefits With High Dose Statins, Study Finds
- Science Daily, 7/3/07 - "The study participants
had a relative reduction in risk of 19 percent for a major cardiovascular
event with high-dose compared with low-dose atorvastatin. The important
feature is that this occurred without any evidence of increase in risk from
the high dose"
-
One
Pill May Be Better Than Two For Treating Patients With High Blood Pressure
- Science Daily, 5/11/07 - "Adults
with high blood pressure and additional risk factors for heart disease may
benefit more from taking one tablet rather than two, if their current
treatment combines the lipid-lowering medication atorvastatin with the blood
pressure-lowering medication amlodipine"
-
Atorvastatin Confirmed as Safe in Older Patients at Increased Cardiovascular
Risk - Doctor's Guide, 5/1/07
-
Atorvastatin Improves Endothelial Function, May Prevent Vascular Damage in
Patients With Type 2 Diabetes - Doctor's Guide, 9/7/06
-
Atorvastatin More Effective Than Simvastatin in Cutting Risk of Additional
Heart Attacks in Patients Who Had a Recent Heart Attack, New Data Suggests
- Doctor's Guide, 9/6/06
-
Effect of Lowering LDL Cholesterol Substantially Below Currently Recommended
Levels in Patients With Coronary Heart Disease and Diabetes - Medscape,
6/14/06 - "lowering LDL cholesterol
to values well below currently recommended levels with more intensive statin
therapy is associated with additional cardiovascular benefit ... Among
patients with clinically evident CHD and diabetes, intensive therapy with
atorvastatin 80 mg significantly reduced the rate of major cardiovascular
events by 25% compared with a more moderate regimen of atorvastatin 10 mg"
-
Lipitor Safety Questioned in Lawsuit - WebMD, 6/9/06 -
"The two lawsuits claim that Lipitor
caused lasting, debilitating muscle and nerve problems -- including memory
loss"
-
Atorvastatin Effective for Stroke Prevention - Doctor's Guide, 5/18/06 -
"the atorvastatin arm (265 events)
showed a significant 16% risk reduction over placebo (311 events)"
-
Atorvastatin Well Tolerated in Older Patients - Doctor's Guide, 4/5/06
-
Erectile Dysfunction and Statin Treatment - Medscape, 3/21/06 -
"Simvastatin was found to cause
impotency in five men with coronary artery disease, and within 1 week of
discontinuing simvastatin, sexual function was restored. The Australian
Adverse Drug Reactions Committee reported 42 cases of ED associated with
simvastatin.[13] In contrast, in one study in men aged 49.7 years and
isolated hypercholesterolaemia [low-density lipoprotein (LDL)-C 4.3 mmol/l]
as a risk factor which used penile Doppler ultrasound in a per protocol
analysis of 50% of the cohort of 18 patients (n = 9), atorvastatin therapy
was associated with improvement in erectile function"
-
Use
Of Statins Shows Improvement In Erectile Performance Of Some Men Who
Previously Did Not Respond Well To Viagra - Science Daily, 2/23/06 -
"There did seem to be some
improvement for those who received Lipitor versus the placebo ... We
theorized that if you could make the edothelium healthier through the use of
statins -- so that there is more nitric
oxide available -- you would improve the endothelial dysfunction and
Viagra would work better for the patient"
-
Impact of Atorvastatin on Cardiovascular Events on Older Patients Not as
Great as Benefit in Younger Patients - Doctor's Guide, 2/21/06
-
Atorvastatin Improves Inflammatory State of Patients with Chronic Kidney
Disease - Doctor's Guide, 11/14/05
-
Administration Time-Dependent Efficacy of Valsartan-Atorvastatin Combination
in Hyperlipidaemic Patients With Essential Hypertension: Presented at EMH
- Doctor's Guide, 6/22/05 -
"160-mg/day dose of valsartan ... 10 mg/day of atorvastatin ... combination
treatment significantly improved systolic/diastolic blood pressure levels (SBP/DBP)
compared to monotherapy (17.1/10.7 vs. 13.9/9.6 mm Hg; P = .027). The same
benefit was seen in terms of pulse pressure (6.4 vs. 4.3 mm Hg ... there
were large significant increases in efficacy seen with the
valsartan/atorvastatin combination dosed at night versus morning (SBP, 23.5
vs. 11.0 mm Hg; DBP, 15.9 vs. 6.8 mm Hg; pulse pressure, 7.8 vs. 4.1 mm Hg"
-
Bedtime Dosing of Atorvastatin and Valsartan Together Improves Overall
Anti-Hypertensive Effects - Doctor's Guide, 5/17/05 -
"When valsartan was dosed by itself
during the day, patients averaged a 9 mmHg fall in systolic blood pressure;
daytime dosing of both valsartan and atorvastatin resulted in a 17 mmHg
reduction in the 24-hour mean of systolic and diastolic BP"
-
Vytorin Slashes Bad Cholesterol to Lower Levels Than Atorvastatin -
Doctor's Guide, 3/9/05
-
Cholesterol-lowering Drug May Slow Alzheimer's Progression - Science Daily, 11/17/04 -
"The cholesterol-lowering drug atorvastatin slowed
down mental decline and improved depressive symptoms in people with Alzheimer’s disease"
- High-Dose Atorvastatin Associated with Worsening Glycemic Control - Doctor's Guide, 11/10/04 -
"Atorvastatin was
associated with a statistically significant increased risk of developing an HbA1c greater than 6 -- both in non-diabetics and in diabetics"
- Atorvastatin Slows Alzheimer's Disease Progression in Pilot Study - Doctor's Guide, 11/10/04
- Cholesterol Drug May Slow Alzheimer's Disease - WebMD, 11/9/04
-
Lipitor May Aid Memory in Alzheimer's - HealthDay, 11/9/04 -
"Removing cholesterol either through the diet or with cholesterol-lowering drugs reversed the
Alzheimer's path in animals ... 80 milligrams of Lipitor ... at one year, 53 percent of the Lipitor group had improved or stabilized vs. 28 percent of those in the placebo group. There was also a significant improvement in depressive symptoms at the end of the year"
- No Muscle-Related Adverse Effects Seen With High-Dose Atorvastatin - Doctor's Guide, 10/27/04
- Atorvastatin Shows Preventive Effect Against Cardiovascular Events in Diabetics - Doctor's Guide, 10/25/04
- Rosuvastatin May Be Better Than Atorvastatin in Patients With Metabolic Syndrome - Doctor's Guide, 10/25/04 -
"The benefits of
rosuvastatin were seen in levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apoprotein (apo)
A-I and apo B, total cholesterol and non-HDL-C"
- Is Lower Really Better for Cholesterol? - WebMD, 9/14/04 -
"high-dose Lipitor decreased
CRP by 38%, while high-dose Zocor reduced CRP by just 17% in the current study"
- Why Some Statins Work Better - Time Magazine, 9/13/04 -
"patients taking high doses of Zocor fared no better than a low-dose group in terms of
heart-attack risk, despite low LDL levels. Why? Perhaps because Lipitor works not just by lowering cholesterol but also by reducing inflammation, something Zocor can't do as well"
- Statins May Provide Anti-Inflammatory Benefit in Patients with Rheumatoid Arthritis - Doctor's Guide, 7/5/04 -
"Primary
outcome measures were change in disease activity score (DAS28) ... the DAS28 improved significantly in the group receiving atorvastatin compared with placebo ... In addition, C-reactive protein declined by 50%"
- Atorvastatin Reduces Blood CoQ10 Levels - Medscape, 6/22/04 -
"Even brief exposure to atorvastatin causes a marked decrease in blood CoQ10 concentration ... Widespread inhibition
of CoQ10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria" - See
Vitacost
coenzyme Q10 products.
- Atorvastatin Therapy Mediated Some Aspects of Disease Activity in Patients with Rheumatoid Arthritis - Doctor's Guide, 6/18/04
- Statins Effectively Lower Cholesterol, But Experts Debate First Choice - Medscape, 3/15/04 -
"HDL cholesterol levels were increased more than 10% with
rosuvastatin 40 mg, nearly 5% with atorvastatin 80 mg, 10% with 40 mg simvastatin, and 6.4% with 40 mg pravastatin"
- Lipid-Lowering Combination May Be More Effective Than High-Dose Atorvastatin - Medscape, 3/12/04 -
"The coadministration
of ezetimibe plus simvastatin provided additional improvements in lipid profiles across a wide range of doses compared with titration of atorvastatin monotherapy"
- Simvastatin/Ezetimibe Combination Outperforms High Dose Atorvastatin in Lowering Cholesterol - Doctor's Guide, 3/9/04
- Atorvastatin May Improve Endothelial Function In Patients with Diabetes and in Healthy Persons At Risk for Type 2 Diabetes - Doctor's Guide, 2/17/04
- Atorvastatin Therapy May Cause Increased Lipid Peroxidation in Patients with Type 1 Diabetes - Doctor's Guide, 12/15/03
- Treatment with Lipitor Reduces LDL-C, Halving Mortality in Patients with Diabetes and Coronary Heart Disease - Doctor's Guide, 11/14/03
- High Dose Atorvastatin Stops Progression of Disease in Patients With Symptomatic Coronary Artery Disease - Doctor's Guide, 11/12/03 -
"After 18
months of treatment, intravascular ultrasound analysis found zero progression in the group treated with atorvastatin, compared with 2.7% progression in the group treated with pravastatin ... atorvastatin stopped plaque progression in each of 22 pre-determined subgroups, while
"we were unable to stop progression in any of the subgroups in the pravastatin arm" - Yeah but the way I read the following, Zocor (simvastatin) not only stopped but reversed progression:
- Simvastatin Increases HDL-C And Apo A-I More Than Atorvastatin in Patients With Hypercholesterolemia - Doctor's Guide, 11/10/03 -
"Simvastatin
appears to increase high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I significantly more than does atorvastatin in patients with hypercholesterolaemia ... Liver toxicity
occurred in significantly fewer patients treated with simvastatin compared to atorvastatin"
- Atorvastatin Has No Clinical Effect on Gonadal or Adrenal Steroid Hormones - Doctor's Guide, 11/3/03
- Atorvastatin Appears to Reduce Arterial Stiffness in Rheumatoid Arthritis Patients - Doctor's Guide, 10/31/03 -
"They
concluded that treatment with atorvastatin significantly reduced arterial stiffness in patients with RA but did not reduce serum CRP"
- Flexible Dosing Plan for Atorvastatin Allows Patients to Achieve Target LDL - Doctor's Guide, 10/6/03
- High-Fat Meals Reduce Rate of Atorvastatin Absorption - Doctor's Guide, 10/3/03
- Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
"Rosuvastatin significantly more
effective than atorvastatin, simvastatin, and pravastatin in improving the ratios of total cholesterol to high-density lipoprotein cholesterol"
- Cholesterol Drug May Ease Intermittent Claudication - WebMD, 9/2/03 -
"Lipitor has the added benefit of improving walking ability in people with
intermittent claudication, a condition caused by blocked leg arteries that leads to cramping and fatigue in the legs and buttocks during exercise, such as walking"
- Statin, Atorvastatin, Increases Pain-Free Walking Distance In Patients With Intermittent Claudication - Doctor's Guide, 9/2/03
- Atorvastastin is Safe and Well Tolerated in Dyslipidaemic Patients - Doctor's Guide, 6/16/03
- Study Compares Extended-Release Lovastatin and Atorvastatin - Doctor's Guide, 6/10/03
- "Eye-Popping" Low-Density Lipoprotein Results from Statin Use Reported - Doctor's Guide, 6/9/03 -
"The percent of patients achieving LDL goal
was highest with atorvastatin and lowest with lovastatin"
- Atorvastatin Addition to High Blood Pressure Treatment Reduces Heart Events - Doctor's Guide, 4/3/03
- Atorvastatin, Simvastatin Effects Similar For Subclinical Atherosclerosis - Doctor's Guide, 1/7/03
- Atorvastatin Every Other Day as Effective as Daily Dose in Lowering Cholesterol - Medscape, 10/25/02 -
"At 12 weeks, LDL-C levels decreased by 35% in the
alternate-day and by 38% in the daily group"
- Atorvastatin Shown to Decrease Heart Disease and Stroke in Patients with Hypertension And Low Cholesterol - Doctor's Guide, 10/11/02
- Simvastatin Increases HDL and Apo-A1 Better Than Atorvastatin - Doctor's Guide, 9/13/02
- Vasoreactivity In Type 2 Diabetes Does Not Improve With Atorvastatin Therapy - Doctor's Guide, 5/21/02
- Low-Dose Atorvastatin Safe and Effective in Children - Doctor's Guide, 5/7/02
- Lipitor (Atorvastatin Calcium) Reduces C-Reactive Protein In Acute Coronary Syndrome - Doctor's Guide, 3/19/02
- Rosuvastatin More Effective Than Atorvastatin In Hypercholesterolemic Patients - Doctor's Guide, 2/13/02
- WelChol (Colesevelam) Combination With Lipitor (atorvastatin) Cuts Cholesterol Levels Significantly - Doctor's Guide, 12/27/01
- Treatment With Simvastatin Results In Artery Plaque Stabilization - Doctor's Guide, 11/12/01
- Atorvastatin Lowers C-Reactive Protein In Mixed And Diabetic Dyslipidemia - Doctor's Guide, 5/21/01
- Lipitor (Atorvastatin) Reduces Angina Recurrence, Urgent Re-admissions In Hospital In-patients - Doctor's Guide, 11/16/00
- Atorvastatin Better than Simvastatin for Achieving Total Cholesterol Targets - Doctor's Guide, 4/12/00
- Zocor (Simvastatin) Increases HDL And apo A-I More Than Lipitor (Atorvastatin) - Doctor's Guide, 3/15/00
- Study Shows Significant Difference Between Two Statins In Raising HDL - Doctor's Guide, 8/25/98
Abstracts:
-
Comparison of Effectiveness of Rosuvastatin Versus Atorvastatin on the
Achievement of Combined C-Reactive Protein (<2 mg/L) and Low-Density
Lipoprotein Cholesterol (<70 mg/dl) Targets in Patients With Type 2 Diabetes
Mellitus (from the ANDROMEDA Study) - Am J Cardiol. 2007 Oct
15;100(8):1245-1248 - "CRP was effectively decreased
in patients with type 2 diabetes receiving rosuvastatin or atorvastatin,
whereas rosuvastatin decreased LDL cholesterol significantly more than
atorvastatin"
-
Effects of Atorvastatin on vitamin D levels in patients with acute ischemic
heart disease - Am J Cardiol. 2007 Apr 1;99(7):903-5 -
"atorvastatin increases vitamin D
levels. This increase could explain some of the beneficial effects of
atorvastatin at the cardiovascular level that are unrelated to cholesterol
levels"
-
The effects of quinapril and atorvastatin on the responsiveness to
sildenafil in men with erectile dysfunction - Vasc Med. 2006
Nov;11(4):251-7 - "International
Index of Erectile Function (IIEF) questionnaire ... Compared to placebo,
quinapril (p < 0.01) significantly improved symptoms of ED as measured by
the IIEF-5 questionnaire. There was a trend toward a significant improvement
in IIEF-5 with atorvastatin"
-
Influences of statins on glucose tolerance in patients with type 2 diabetes
mellitus - J Atheroscler Thromb. 2006 Apr;13(2):95-100 -
"atorvastatin-treated group (Group A
... arbitrary blood glucose levels increased from 147 +/- 50 (mean +/- SD)
mg/dL to 177 +/- 70 mg/dL in Group A"
-
Effect of Atorvastatin (10 mg/day) on Glucose Metabolism in
Patients With the Metabolic Syndrome - Am J
Cardiol. 2006 Jul 1;98(1):66-9 - "in
insulin-resistant, nondiabetic subjects, 6 weeks of atorvastatin (10 mg/day)
resulted in significant improvement in insulin sensitivity"
-
Influences of statins on glucose tolerance in patients with type 2 diabetes
mellitus - J Atheroscler Thromb. 2006 Apr;13(2):95-100 -
"compared an atorvastatin-treated
group (Group A, n = 76) with a pravastatin-treated group (Group P, n = 78)
... blood glucose levels increased from 147 +/- 50 (mean +/- SD) mg/dL to
177 +/- 70 mg/dL in Group A ... These results suggest a predisposition to a
deterioration of glycemic control in type 2 diabetic patients treated with
atorvastatin"
-
High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention
After Myocardial Infarction - JAMA. 2005;294:2437-2445
-
Effect of atorvastatin on regional arterial stiffness in patients with type
2 diabetes mellitus - J Atheroscler Thromb. 2005;12(4):205-10 -
"Atorvastatin treatment was
associated with an improvement in the stiffness of leg arteries in type 2
diabetes mellitus. This may partly explain the statin-mediated improvement
of walking performance in those with PAD"
-
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at Risk for Cardiovascular Disease and Stroke - Arch Neurol. 2004;61:889-892 -
"Even brief exposure to atorvastatin causes a marked decrease in blood CoQ10 concentration. Widespread inhibition of CoQ10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia,
and myoglobinuria" - See
Vitacost
coenzyme Q10 products.
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