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Anti-aging Research > Antioxidants.
Antioxidants
Specific Recommendations:
News & Research:
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Antioxidant spices, like turmeric and cinnamon, reduce negative effects of
high-fat meal - Science Daily, 8/10/11 - "Normally,
when you eat a high-fat meal, you end up with high levels of triglycerides, a
type of fat, in your blood ... If this happens too frequently, or if
triglyceride levels are raised too much, your risk of heart disease is
increased. We found that adding spices to a high-fat meal reduced triglyceride
response by about 30 percent, compared to a similar meal with no spices added
... Antioxidants, like spices, may be important in reducing oxidative stress and
thus reducing the risk of chronic disease"
-
Reduction of
circulating superoxide dismutase activity in type 2 diabetic patients with
microalbuminuria and its modulation by telmisartan therapy - Hypertens Res.
2011 Aug 4 - "Interestingly, the telmisartan treatment not only reduced the
circulating levels of two oxidative stress markers, 8-hydroxy-2'-deoxyguanosine
(8-OHdG) and nitrotyrosine (NT), but also enhanced serum SOD activity. Notably,
a significant correlation was observed between the increase in serum SOD
activity and the reduction in albuminuria. We further compared the
anti-oxidative effect of telmisartan with that of losartan, another member of
the ARB class, by implementing an 8-week interval crossover treatment with these
ARBs in another 12 microalbuminuric type 2 diabetic patients. The patients
showed higher serum SOD activity, and lower circulating levels of 8-OHdG and NT,
during treatment with telmisartan than with losartan. These results suggest that
telmisartan has a more potent antioxidative effect through its ability to
enhance SOD activity in type 2 diabetic patients with microalbuminuria" - See
telmisartan at
OffshoreRX.com.
-
Antioxidants of growing interest to address infertility, erectile dysfunction
- Science Daily, 7/28/11 - "A growing body of evidence
suggests that antioxidants may have significant value in addressing infertility
issues in both women and men, including erectile dysfunction, and researchers
say that large, specific clinical studies are merited to determine how much they
could help ... Some commonly used antioxidants, such as vitamins C and E, could
help, Hagen said. But others, such as lipoic acid, are a little more
cutting-edge and set up a biological chain reaction that has a more sustained
impact on vasomotor function and health ... Polyphenols, the phytochemicals that
often give vegetables their intense color and are also found in chocolate and
tea, are also of considerable interest"
-
A novel
and potent antioxidant found in tomato plants, initial results suggest -
Science Daily, 7/22/11 - "A team of researchers from the
Institute of Molecular and Cell Biology (IBMCP) -a joint centre of the
Universitat Politècnica de València and CSIC, the Spanish National Research
Council- have identified a novel and potent natural antioxidant occurring in
tomato plants. It is a phenolic substance that is synthesised by the tomato
plant when it is subjected to biotic stress. Until now, it was completely
unknown ... The UPV and CSIC have registered the national and international
patents of the new antioxidant and the laboratory procedures used to isolate and
synthesise it chemically ... the antioxidant power of the new compound is much
higher -14 times higher, to be precise- than, for example, that of resveratrol,
a well-known antioxidant, found in red wine, which can delay cellular aging. In
addition, it is 4.5 times more potent than vitamin E and 10 times more potent
than vitamin C" - Note: The patent thing makes you wonder if the
claims are overblown though.
-
High
Antioxidant Intake May Lower Risk for Early AMD - Medscape, 6/14/11 -
"We assessed the intake of antioxidants, zinc, and ω-3
fatty acids in daily foods, diagnosed the onset of early AMD during a lengthy
follow-up, and investigated the risk-reducing effect of these nutrients in the
various genotypes of CFH [complement factor H] Y402H and LOC387715 A69S ...
Median follow-up duration was 8.6 years ... There appeared to be a possible
biological interaction between the CFH Y402H genotype and intakes of zinc,
β-carotene, lutein/zeaxanthin, and eicosapentaenoic/docosahexaenoic acid
(EPA/DHA), and between the LOC387715 A69S genotype and zinc and EPA/DHA, based
on significant synergy indices ... High dietary intake of nutrients with
antioxidant properties reduces the risk of early AMD in those at high genetic
risk"
-
How
vitamins and minerals may prevent age-related diseases - Science Daily,
5/31/11 - "Severe deficiency of the vitamins and
minerals required for life is relatively uncommon in developed nations, but
modest deficiency is very common and often not taken seriously. A new research
published online in the FASEB Journal, however, may change this thinking as it
examines moderate selenium and vitamin K deficiency to show how damage
accumulates over time as a result of vitamin and mineral loss, leading to
age-related diseases ... If the principles of the theory, as demonstrated for
vitamin K and selenium, can be generalized to other vitamins and minerals, this
may provide the foundation needed ... They discovered a highly sophisticated
array of mechanisms at cellular and tissue levels that, when selenium is
limited, protect essential selenium-dependent proteins at the expense of those
that are nonessential. They also found that mutations in selenium-dependent
proteins that are lost on modest selenium deficiency result in characteristics
shared by age-related diseases including cancer, heart disease, and loss of
immune or brain function"
-
Naturally occurring plant alkaloids could slow down Alzheimer's disease, study
suggests - Science Daily, 5/26/11 - "Beta-carboline
alkaloids could potentially be used in therapeutic drugs to stop, or at least
slow down, the progressively debilitating effects of Alzheimer's ... Beta-carboline
alkaloids are found in a number of medicinal plants. They have antioxidant
properties, and have been shown to protect brain cells from excessive
stimulation of neurotransmitters. "(They) are natural occurring compounds in
some plant species that affect multiple central nervous system targets,""
-
Antioxidant formula prior to radiation exposure may prevent DNA injury, trial
suggests - Science Daily, 3/29/11 - "In what the
researchers say is the first clinical trial of its kind, as much as a 50 percent
reduction in DNA injury was observed after administering the formula prior to CT
scans"
-
Antioxidants may improve chances of conceiving in male subfertility -
Science Daily, 1/18/11 - "Compared to controls, a couple
was more likely to have a pregnancy or live birth if the man took antioxidants"
-
Eating
berries may activate the brain's natural housekeeper for healthy aging -
Science Daily, 8/23/10 - "berries, and possibly walnuts,
activate the brain's natural "housekeeper" mechanism, which cleans up and
recycles toxic proteins linked to age-related memory loss and other mental
decline ... natural compounds called polyphenolics found in fruits, vegetables
and nuts have an antioxidant and anti-inflammatory effect that may protect
against age-associated decline"
-
Dietary
Antioxidant and Mineral Intake in Humans Is Associated with Reduced Risk of
Esophageal Adenocarcinoma but Not Reflux Esophagitis or Barrett' Esophagus -
J Nutr. 2010 Aug 11 - "We found that overall antioxidant
index, a measure of the combined intake of vitamin C, vitamin E, total
carotenoids, and selenium, was associated with a reduced risk of EAC [odds ratio
(OR) = 0.57; 95% CI = 0.33-0.98], but not BE (OR = 0.95; 95% CI = 0.53-1.71) or
RE (OR = 1.60; 95% CI = 0.86-2.98), for those in the highest compared with
lowest category of intake. Those in the highest category of vitamin C intake had
a lower risk of EAC (OR = 0.37; 95% CI = 0.21-0.66; P-trend = 0.001) and RE (OR
= 0.46; 95% CI = 0.24-0.90; P-trend = 0.03) compared with those in the lowest
category. Vitamin C intake was not associated with BE, and intake of vitamin E,
total carotenoids, zinc, copper, or selenium was not associated with EAC, BE, or
RE. In conclusion, the overall antioxidant index was associated with a reduced
risk of EAC. Higher dietary intake of vitamin C was associated with a reduced
risk of EAC and RE. These results suggest that antioxidants may play a role in
the pathogenesis of RE and EAC and may be more important in terms of progression
rather than initiation of the disease process"
-
Natural
substance NT-020 aids aging brains in rats, study finds - Science Daily,
7/20/10 - "Aging has been linked to oxidative stress,
and we have previously shown that natural compounds made from blueberries, green
tea, and amino acids, such as carnosine, are high in antioxidants and have
anti-inflammatory and anti-oxidative activity .... The combination of these
nutrients, called NT-020, creates a synergistic effect that promotes the
proliferation of stem cells in the aged animals ... NT-020 may have not only a
positive effect on the stem cell niche ... NT-020 may have far-reaching effects
on organ function beyond the replacement of injured cells, as demonstrated by
cognitive improvement in the NT-020 group"
-
Antioxidants do help arteries stay healthy - Science Daily, 7/5/10 -
"Long-term supplementation with dietary antioxidants has
beneficial effects on sugar and fat metabolism, blood pressure and arterial
flexibility in patients with multiple cardiovascular risk factors ... receive
either antioxidants or placebo capsules for six months. Tests at the beginning
of the trial, after three months and at the six month mark revealed that the
patients in the antioxidant group had more elastic arteries (a measure of
increased cardiovascular health) and better blood sugar and cholesterol
profiles"
-
Well-defined quantity of antioxidants in diet can improve insulin resistance,
study finds - Science Daily, 6/21/10 - "For groups C and D, the researchers
prescribed a diet enriched in antioxidant, with a calculated intake, 800 to
1,000 milligrams a day, coming from fruits and vegetables, but group D also took metformin ... Despite similar weight loss in all the groups, only the two groups
receiving the antioxidant diet (groups C and D) had a significant decrease in
insulin resistance ... Group D had the best improvement in insulin resistance on
some measures of insulin response to an oral glucose tolerance test ... We think
that a total antioxidant level of 800 to 1,000 milligrams a day is safe and
probably not close to the maximum tolerable level"
-
Supplement your stem cells - Science Daily, 4/7/10 -
"supplement, containing a cocktail of green tea, astralagus, goji berry
extracts, 'good' bacteria Lactobacillus fermentum, antioxidant ellagic acid,
immune enhancer beta 1,3 glucan and vitamin D3, was able to increase the number
of stem cells circulating in the blood ... Hematopoietic stem cells and
endothelial progenitor cells increased after taking the nutritional supplement,
suggesting that the supplement may be a useful stimulator for both types of stem
cells. In this study, the levels of these stem cells peaked at 2-7 days and
started to drop at 14 days, suggesting that this supplement could be used for
continuous treatment for conditions associated with decreases in these stem
cells such as Alzheimer's Disease ... it may be possible that our supplement
could be beneficial in conditions associated with reduced progenitor cells such
as diabetes"
-
Vitamin combo may delay ageing: Mouse study - Nutra USA, 3/1/10 -
"Results showed maintenance of youthful levels of
locomotor activity into old age in the supplemented animals, whereas old
non-supplemented mice showed a 50 per cent loss in daily movement, said the
researchers. This was accompanied by a loss of mitochondria activity, and
declines in brain signalling chemicals relevant to locomotion, such as striatal
neuropeptide Y. This chemical is associated with a range of functions, including
maintaining energy balance, as well as effects in memory and learning ... No
such declines were observed in supplemented animals ... The supplement was
composed of vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid,
beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea
extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium,
potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin,
alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and
flax seed oil"
-
Dietary
Antioxidants Could Help Preserve Muscle Strength in Older Adults - Medscape,
11/23/09 - "In a study in older adults, dietary intake
of vitamins C and E was linked with muscle strength, leading the researchers to
suggest at a meeting in Atlanta this past weekend that a diet high in
antioxidants could play an important role in preserving muscle function in older
adults ... Muscle strength is really a marker of aging ... Muscle strength
starts declining when people are in their 40s, but it decreases dramatically
after age 60 ... At this point, it's not clear whether vitamins C and E
specifically help preserve muscle strength, or if intake of these micronutrients
is a marker of a healthy diet"
-
Scientists Discover Influenza's Achilles Heel: Antioxidants - Science Daily,
10/29/09 - "antioxidants -- the same substances found in
plant-based foods -- might hold the key in preventing the flu virus from
wreaking havoc on our lungs"
-
Could
Antioxidants Make Us More, Not Less, Prone To Diabetes? Study Says Yes -
Science Daily, 10/6/09
-
Antioxidant Ingredient Proven To Relieve Stress - Science Daily, 9/14/09 -
"The 35 people in our study who received capsules
containing superoxide dismutase showed improvement in several signs and symptoms
of perceived stress and fatigue" - See
SOD products at iHerb
 .
-
Whole
Grain Cereals, Popcorn Rich In Antioxidants, Not Just Fiber, New Research
Concludes - Science Daily, 8/19/09 - "We found that,
in fact, whole grain products have comparable antioxidants per gram to fruits
and vegetables. This is the first study to examine total phenol antioxidants in
breakfast cereals and snacks, whereas previous studies have measured free
antioxidants in the products ... Polyphenols are a group of chemicals found in
many fruits, vegetables, and other plants, such as berries, walnuts, olives, tea
leaves and grapes. Known as antioxidants, they remove free radicals from the
body. Free radicals are chemicals that have the potential to cause damage to
cells and tissues in the body"
-
Antioxidant vitamins may protect against female cancer - Nutra USA, 6/3/09 -
"for every 1,000 microgram increase per 1,000 kcal of
diet of beta-carotene was associated with a 12 per cent reduction in the risk of
endometrial cancer ... Similarly, for every 50 milligram increase per 1,000 kcal
of vitamin C the risk of endometrial cancer was reduced by 15 per cent, and for
every 5 milligram increase per 1,000 kcal of vitamin E the risk of endometrial
cancer was reduced by 9 per cent" - [Abstract]
-
Semen
Quality May Depend Upon Antioxidants In Man's Diet - Science Daily, 6/2/09 -
"Low antioxidant intake is associated with low
reproductive capacity in semen"
-
Antioxidants needed by exercising populations: Nutritionist - Nutra USA,
5/14/09 - "Commenting on the design of the study, Dr
Childs said it was unclear if the subjects encountered the same absolute level
of muscle fatigue during exercise in the supplement and control conditions and
hence stimulus for antioxidant up-regulation. “Because of this, the reported
‘prevention of the ‘health promoting effects of antioxidants’ may be nothing
more than an experimental artefact,” ... In addition, Dr Childs said that
comments by the authors that antioxidants may block many of the beneficial
effects of exercise were a “gross over extrapolation of the experimental
findings on two levels”"
-
Vitamin-exercise study questioned - Nutra USA, 5/12/09 -
"The authors noted that biopsies for the ‘early’
time-point were only obtained from five people in the vitamin group, and four in
the placebo group. “Yet the authors conclude a “strong induction of PGCl-alpha,
PGCl-beta, and PPAR-gamma expression in skeletal muscle following 4 weeks of
exercise training in previously untrained, antioxidant naïve individuals” and
“markedly reduced exercise-related induction” in those taking antioxidants,
based on these limited number of biopsies,” ... “Would it not have made more
sense to appropriately increase the intensity and duration of exercise slowly
and then see if the subject’s bodies didn’t accommodate handling of ROS without
a significant change in induction of these markers?” ... The study reflects a
‘transient’ increase in ROS during ‘limited periods of physical exercise only’,
noted Dr Schauss, “whereas the bulk of the literature, including that in
non-primate models have not observed these concerns obtained in models of
‘continuous exposure to increased levels of ROS’” ... the authors presented no
evidence of adverse effects by any of the individuals from vitamin C and E
supplementation"
-
Do Antioxidants Curb an Exercise Benefit? - WebMD, 5/11/09 -
"Physical activity induced an increase in insulin
sensitivity only in the absence of antioxidants"
-
Antioxidant Found In Berries, Other Foods Prevents UV Skin Damage That Leads To
Wrinkles - Science Daily, 4/21/09 - "Using a topical
application of the antioxidant ellagic acid, researchers at Hallym University in
the Republic of Korea markedly prevented collagen destruction and inflammatory
response – major causes of wrinkles -- in both human skin cells and the
sensitive skin of hairless mice following continuing exposure to UV-B, the sun's
skin-damaging ultraviolet radioactive rays ... Ellagic acid is an antioxidant
found in numerous fruits, vegetables and nuts, especially raspberries,
strawberries, cranberries and pomegranates ... the results demonstrate that
ellagic acid works to prevent wrinkle formation and photo-aging caused by UV
destruction of collagen and inflammatory response"
-
Reductions In Cancer And Overall Mortality Persist 10 Years After Vitamin And
Mineral Supplementation - Science Daily, 4/2/09 - "Individuals
who took a dietary supplement called "factor D", which included selenium,
vitamin E, and beta-carotene, continued to have lower gastric cancer and overall
mortality 10 years after supplementation ceased compared with individuals who
did not take the supplements ... Individuals who took factor D continued to show
benefits, with a 5% reduction in overall mortality (from a cumulative mortality
of 33.62% of participants not taking factor D to 32.19% of participants taking
factor D) and an 11% reduction in gastric cancer mortality (from a cumulative
gastric cancer mortality of 4.28% in the no-factor D group to 3.84% in the
factor D group)"
-
Cholinesterase Inhibition Combined With Antioxidants May Help Alzheimer's
Disease Outcomes - Doctor's Guide, 3/17/09 -
"Addition of a defined antioxidants formulation (Formula F) to donepezil
treatment of patients with mild Alzheimer's disease (AD) substantially reduces
oxidative stress and provides significant benefits over treatment with donepezil
alone"
-
Antioxidants Offer Pain Relief In Patients With Chronic Pancreatitis -
Science Daily, 1/1/09 - "In this placebo-controlled,
double blind trial, 127 patients, ages 30.5+/-10.5, were assigned to placebo or
antioxidant groups. After six months, the reduction in the number of painful
days/month was significantly higher in the antioxidant group, compared with the
placebo group (7.4±6.8 versus 3.2±4, respectively). The reduction in the number
of analgesic tablets/month was also higher in the antioxidant group (10.5±11.8
versus 4.4±5.8, respectively). Furthermore, 32 percent and 13 percent of
patients became pain free in the antioxidant and placebo groups, respectively;
the beneficial effect of antioxidants on pain relief was noted early at three
months"
-
Antioxidants Can Reduce The Toxic Effects Of Lead, Study Suggests - WebMD,
10/31/08 - "administering natural antioxidants can
reduce the effects of lead poisoning in animals during the gestation and
lactation periods"
-
Antioxidants Could Help Huntington’s Disease Sufferers, Study Suggests -
Science Daily, 10/10/08 - "strategies to strengthen
antioxidant defences could help to prevent the progression of Huntington’s
Disease ... oxidative stress and damage to certain macromolecules are involved
in the progression of Huntington’s Disease (HD)"
-
Antioxidant Deficiency Linked To Pulmonary Hypertension - Science Daily,
9/23/08 - "Antioxidant augmentation in patients might be
used to increase nitric oxide vasodilator effects, reduce pulmonary artery
pressures and potentially improve clinical outcomes"
-
How
Diet, Antioxidants Prevent Blindness In Aging Population - Science Daily,
8/25/08 - "They found antioxidants disrupt the link and
extend the lifetime of irreplaceable photoreceptors and other retinal cells ...
The implication is that people at risk of macular degeneration could help
prevent the disease by consuming antioxidants ... The experiments performed with
visual cells from rats, cows and humans showed that antioxidants could
completely counter the damage"
-
Good
News In Our DNA: Defects You Can Fix With Vitamins And Minerals - Science
Daily, 6/2/08 - "He also is investigating how enzyme
cofactors like vitamins and minerals fix defective enzymes. He suspects that
supplements work by acting as chaperones to stabilize the proper folding of the
enzyme, which is critical to its catalytic activity"
-
How
Antioxidant Therapy May Play A Role In The Treatment Of Type 2 Diabetes -
Science Daily, 1/11/08 - "Mice fed a high-fat,
high-sucrose diet (HFHSD) developed insulin resistance and type 2 diabetes ...
mitochondrial defects were present in diabetic, but not pre-diabetic glucose
intolerant, mice ... ROS production coincided with mitochondrial dysfunction,
and antioxidant treatment blocked the mitochondrial alterations in muscle cells"
-
Antioxidants may stop fat cells formation, says study - Nutra USA, 11/12/07
- "These results suggest that o-coumaric acid and rutin
targeted for adipocyte functions could be effective in improving the symptoms of
metabolic syndrome" - [Abstract]
-
Antioxidants May Fight Fat - WebMD, 11/2/07 - "Those
antioxidants didn't kill fat cells or slash the number of fat cells in the test
tubes. Instead, they made fat cells cut their production of triglycerides, which
are a heart hazard. The antioxidants did that by curbing an enzyme needed to
make triglycerides ... That particular enzyme was most effectively reduced by
the phenolic acid o-coumaric acid and the flavonoid rutin"
-
Antioxidant To Retard Wrinkles Discovered - Science Daily, 8/30/07 -
"Antioxidants operate against free radicals which cause
a breakdown of many tissues in the body, including the skin. When found in small
quantities in the body, free radicals are not harmful and are even involved in
various physical processes. When there is an excess of free radicals, however,
as occurs during normal aging or as a result of excessive exposure to
ultra-violet radiation from the sun, the result, among other things, is a
breakdown of the collagen and elastin fibers in the skin. When this happens,
there is a loss of skin elasticity and the formation of wrinkles ... A problem
with many of the commercial antioxidants found today in the market that are said
to retard the aging process is that they oxidize quickly and therefore their
efficiency declines with time"
-
Chemists
Discover New Way Antioxidants Fight Debilitating Diseases - Science Daily,
8/19/07 - "antioxidants even at low concentrations found
in these foods bind to iron and copper and prevent DNA damage"
-
Antioxidant Found In Many Foods And Red Wine Is Potent And Selective Killer Of
Leukemia Cells - Science Daily, 4/23/07 -
"anthocyanidins, a group of naturally
occurring compounds widely available in fruits and vegetables as well as red
wine, have chemopreventive properties ... the most common type of a naturally
modified anthocyanidin, known as cyanidin-3-rutinoside, or C-3-R ... C-3-R
caused about 50 percent of a human leukemia cell line known as HL-60 to undergo
programmed cell death"
-
Pros And
Cons Of Antioxidants From Fruits And Vegetables - Science Daily, 4/18/07
-
Nutrient Combo May Curb Hearing Loss - WebMD, 3/30/07 -
"The guinea pigs that got the
combination treatment of magnesium and vitamins A, C, and E had the least amount
of noise-induced hearing loss and ear damage"
-
Use of Some Antioxidant Supplements May Increase Mortality Risk - Doctor's
Guide, 2/28/07 - "In an analysis that
pooled all low-bias risk and high bias risk trials, there was no significant
association between antioxidant use and mortality. In 47 low-bias trials
involving 180,938 participants, the antioxidant supplements were associated with
a 5% increased risk of mortality. Among low-bias trials, use of beta carotene,
vitamin A, and vitamin E was associated with 7%, 16% and 4%, respectively,
increased risk of mortality, whereas there was no increased mortality risk
associated with vitamin C or selenium use" - [Abstract]
- Note: Beta-carotene is just one of over 600 carotenoids and taking just
one may cause a deficiency of the others. I had a couple articles on that
but the links went dead. Same with taking just the alpha tocopherol form
(most common form) of vitamin E. I've been saying for years that taking
alpha tocopherol or beta-carotene alone causes more harm than good. I get
my beta-carotene from
Dunaliella Salina Algae
(Body Wise Brand), which
contains the broad spectrum and vitamin E from
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb
 .
See:
-
Antioxidant Supplements Up Death Risk - WebMD, 2/27/07
-
Replenishing The Aging Body’s Antioxidant Defenses - Life Extension
Magazine, 1/07 - "Breakthroughs in
nutritional science have led to the development of orally ingested, highly
bioavailable forms of SOD. Combining orally available SOD with wolfberry offers
a highly effective strategy to boost SOD levels and activity in the body. This
novel combination protects against pain and inflammation, helps prevent a host
of degenerative diseases, restores youthful energy and vitality, and promotes a
long and healthy life span" - See
SODzyme products at iHerb.
-
Research
Finds Antioxidant Therapies Do Not Interfere With Radiation Treatment -
Science Daily, 11/12/06 - "Radiation
Therapy for Prostate Cancer, was conducted by researchers ... Researchers found
no difference between patients taking antioxidants and those who did not.
Antioxidants used in the study included green tea extract, melatonin,
high-potency multivitamins, vitamin C and vitamin E"
-
Apple
Juice May Boost Memory - WebMD, 8/4/06 -
"consumption of antioxidant-rich foods
such as apples and apple juice can help reduce problems associated with memory
loss"
-
Antioxidants May Slow Vision Loss - Science Daily, 7/20/06 -
"Scientists at Johns Hopkins have
successfully blocked the advance of retinal degeneration in mice with a form of
retinitis pigmentosa (RP) by treating them with vitamin E, alpha-lipoic acid and
other antioxidant chemicals"
-
Mushrooms Full of Antioxidants - WebMD, 6/27/06 -
"white button mushrooms -- the ones you
might put on a nice, lean steak -- have more antioxidant capacity than tomatoes,
green peppers, pumpkins, zucchini, carrots, or green beans"
-
Healthy
Antioxidants: How Much a Day? - WebMD, 5/11/06 -
"They found the overall daily intake of
anthocyanins was 12.5 milligrams per day, much less than estimates published in
the 1970s that put average daily anthocyanin intake at 215 milligrams in summer
and 180 milligrams in winter ... Incorporating frozen berries into the diet
during the winter months or using nutritional supplements rich in anthocyanins
may also help boost Americans' intake of these nutrients"
-
Antioxidants, Mitochondrial Damage, and Human Aging
- Life Extension Magazine, 2/06 - "some researchers believe that intramuscular mitochondrial DNA
damage caused by free radicals may be a significant factor in the loss of muscle
mass seen in the aged ... "
-
Antioxidants Reduce Visual Acuity Loss in Patients with
Advanced Age-Related Macular Degeneration - Doctor's
Guide, 10/26/05 -
"The high-dose
formulation has been shown to have beneficial effects in reducing by 25% the
risk of advanced AMD ... The first group received three antioxidant vitamins:
vitamin C 500 mg, vitamin E 400 IU, and beta carotene 15 mg. Group two received
zinc oxide 80 mg, plus cupric acid 2 mg. The third group received the
antioxidant vitamins plus the zinc and cupric oxide"
-
Antioxidants may not be answer to ageing - Nutra USA, 7/18/05
-
Antioxidant-rich Diets Reduce Brain Damage From Stroke In Rats - Science
Daily, 7/1/05 - "rats fed diets
preventatively enriched with blueberries, spinach or an algae known as
spirulina experienced less brain cell loss and improved recovery of movement
following a stroke"
-
Red Delicious apples pack most antioxidant punch - USATODAY.com, 6/5/05
-
Oral antioxidants may be sun burn barrier - Nutra USA, 6/2/05
-
Do Antioxidants Lengthen Life? - WebMD, 5/5/05 -
"mice that made more of an
antioxidant called catalase lived longer than normal ... How much extra time
did the mice get? About five months, on average -- an 18.5% increase in life
span for a mouse ... Heart disease, cataract development, and other signs of
age-related damage were delayed or reduced"
- Antioxidants teach old dogs new tricks - Nutra
USA, 1/18/05 - "old dogs that were on diet fortified with antioxidants such as vitamin E,
vitamin C, and beta-carotene performed better on a variety of cognitive
tests than dogs that were not on the diet"
-
'Purple Berries' Rank High In Antioxidants, USDA Study Says - Science
Daily, 12/23/04
-
Blueberries May Lower Blood Fat/Cholesterol - WebMD, 8/23/04 -
"Pterostilbene -- the fat-fighting compound in blueberries -- has been found
to have cancer-fighting and diabetes-fighting properties"
- Antioxidants During Pregnancy May Help Prevent Birth Defects Tied To Alcohol
- Science Daily, 6/21/04
- Antioxidant Riches Found in Unexpected Foods -
WebMD, 6/17/04
- Largest USDA Study Of Food Antioxidants Reveals Best Sources
- Science Daily, 6/17/04 - "Cranberries, blueberries, and blackberries ranked highest among the fruits
studied. Beans, artichokes and Russet potatoes were tops among the
vegetables. Pecans, walnuts and hazelnuts ranked highest in the nut
category"
- When Good Antioxidants Are Bad - WebMD, 6/14/04
- Do Antioxidants Contribute to Heart Disease? -
WebMD, 5/3/04
- Honey Sweetens Your Health - WebMD, 3/29/04
- Diet May Improve Cognition, Slow Aging, And Help Protect Against Cosmic
Radiation - Intelihealth, 11/10/03 - "The role of diet in cognitive function is one of the vastly understudied
areas in the neurosciences ... old dogs that were on an antioxidant diet
performed better on a variety of cognitive tests than dogs that were not on
the diet ... aged rats on the blueberry-enriched diet had lower NF-kappaB
levels than aged rats fed a control data ... among the aged rats, the higher
the NF-kappaB
levels, the poorer their memory scores"
-
Antioxidants May Protect Women From Alzheimer's - Clinical Psychiatry
News, 10/03 - "Compared with women in the lowest quartile of overall
antioxidant consumption, those in the highest quartile had an OR of 0.39 for
Alzheimer's disease ... When their diets were analyzed for specific
antioxidants, women who consumed the most vitamin C and lycopene also had a
significantly lower risk of cognitive decline"
- Can
healthier living help your skin? - MSNBC, 9/5/03 -
"Antioxidants are currently considered to be potent skin protectors. Normal
body processes produce free radicals, highly reactive molecules that damage
the DNA of our cells ... Ultraviolet light, smoking, alcohol and pollution
increase free radical formation. Researchers say damage from free radicals
leads to skin wrinkling, redness, brown “age spots” and increased risk of
skin cancer. Antioxidants neutralize free radicals and even repair some of
the damage done ... For now, scientists aren’t sure whether antioxidants are
best applied in lotions or creams or consumed in foods or supplements"
- What do you
think of the new study showing that antioxidants don’t cut the risk of heart
disease - Dr. Weil, 7/14/03 - "If you want to supplement your diet, take a product that provides as many
members of this family of protective pigments as possible: alpha-carotene,
lutein, zeaxanthin, lycopene, etc. As for vitamin E, most studies use
synthetic alpha-tocopherol. I recommend using natural vitamin E supplements
that provide all four tocopherols and all four tocotrienols"
- Antioxidants May Protect Against Alcohol Damage -
Intelihealth, 6/3/03 - "fed rats a
liquid diet containing alcohol for six weeks ... They found a 66 percent
decrease in the number of new cells in crucial parts of the brain and an
increase in cell death of more than 227 percent ... But in rats that also
received injections of the antioxidant ebselen, the damage to developing
cells did not occur ... The antioxidant ebselen
was used because it is known to have protective effects in the liver and
digestive tract and has few side effects in humans"
- Three-year Follow-up Shows Antioxidant Treatment Improves Friedreich's
Ataxia - Doctor's Guide, 11/15/02
-
More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical
Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy
for reducing Alzheimer's disease (AD) risk
that includes low fat intake and high consumption of
fish and antioxidants, along with vitamin E,
folic acid, and
vitamins B6 and B12 supplements"
- MEDLINE Abstracts: Antioxidants and the Aging Brain
- Medscape, 9/27/02 - "Combinations
of antioxidants might be of even greater potential benefit for AD,
especially if the agents worked in different cellular compartments or had
complementary activity (e.g. vitamins E, C and
ubiquinone). Naturally-occurring compounds with antioxidant capacity are
available and widely marketed (e.g. vitamin C,
ubiquinone,
lipoic acid,
beta-carotene, creatine,
melatonin, curcumin) and synthetic
compounds are under development by industry" - Again, a broad
spectrum of anti-oxidants, not just one or two.
-
Antioxidant Reduces Stroke Damage - WebMD, 10/1/02 -
"A new study shows the antioxidant, known as
AEOL
10150, neutralized hazardous free radicals and prevented cell death in a
mouse model of stroke. Researchers say the
antioxidant is designed to mimic a natural antioxidant, but it works against
a wider range of free radicals and also lasts longer in the body" -
That last sentence is why I take as large a variety of anti-oxidants as
possible though out the day. I had a good article on my home page that
explained why different anti-oxidants were required by various free radicals
but the link went dead.
- Fat Abnormalities Hold Gehrig's Clue -
Intelihealth, 9/16/02 - "Free
radicals have long been thought to play a role in
ALS, and some ALS specialists advise taking antioxidant vitamins in
hopes of curbing them. In Mattson's experiment, published in this month's
Annals of Neurology, free radicals caused
ceramides
to rise inside those crucial nerve cells ... Indeed, doctors like Newman
expect medications, not diet, to ultimately hold the key. For now, Newman
advises patients just to eat the moderate-fat diet the government already
recommends for a healthy heart and take antioxidants such as
vitamin E as a precaution"
-
Antioxidants Fight Alzheimer's - WebMD, 6/25/02
-
Your Health - Time Magazine, 6/24/02 - "High-fat, high-calorie fast-food meals don't just make you fat; they may
also raise the level of free radicals in the blood, triggering
inflammation that can damage the lining of blood vessels. That's the bad
news. The good news is that taking a few antioxidant vitamins such as
E and C with your fast food can nullify
the inflammatory response"
- High Oxidative Stress, Low Antioxidant Status In Alzheimer Disease
- Doctor's Guide, 6/3/02 - "Lymphocyte DNA 8-OHdG content in people AD
may thus reflect a condition of increased oxidative stress related to a poor
antioxidant status ... researchers also noted a significant inverse
relationship between lymphocyte DNA 8-OHdG content [a marker of oxidative
damage to DNA] and plasma levels of
lycopene, lutein, a-carotene and b-carotene,
respectively"
-
Nutrition for the Skin - What You Should Know Before Undergoing a Surgical
Procedure - Wellness Insider, 5/23/02 - "free radicals can accelerate the aging process of the skin, resulting in
wrinkles and sunspots, not to mention an increased risk of skin cancer
... These antioxidants are important in protecting you from disease and can
help shield you from skin cancer, maintain youthful,
healthy skin, and even help to promote and expedite the healing process
after a surgical procedure"
- Say Cheers: White Wine May Aid Lungs - Doctor's
Guide, 5/21/02
-
The Lungs Favor White Wine - WebMD, 5/20/02 - "those studies have shown that a daily dose of 1 to 3 glasses of red wine
can improve cardiovascular health
... We found that white wine intake was strongly associated with better
[lung] function ... One glass of wine per day equaled a 1.5% higher lung
function, adding one or two more years to the person's lifetime; 3 glasses a
day improved lung capacity by 3% ... He speculates that white wine drinkers
have higher levels of vitamin antioxidants
in their blood" - Also see grape seed
extract/Pycnogenol and flavonoids.
-
Black Raspberries Fight Cancer - WebMD, 5/3/02 - "Earlier studies have shown that blueberries and strawberries also have
cancer-preventing properties. But black raspberries seem to work even
better. Berries are chock full of antioxidants, chemicals that help block
tumors from forming. Antioxidants sop up cancer-causing molecules called
free radicals -- damaging substances produced from your body's everyday
functions"
- Gene Scientists Find Clues To Why We Age -
Intelihealth, 4/12/02
- Vitamin C And E Slow Arteriosclerosis After Heart Transplant
- Doctor's Guide, 3/28/02
-
Vitamins Help After Heart Transplant - WebMD, 3/28/02 -
"The plaque-fighting benefits of the
antioxidant supplements were even greater than those found using statin
medications, which have already been shown to slow hardening of the arteries
after transplants. Previous research has shown that antioxidants, such as
vitamin C and E, can promote heart health
by reducing blood clots and keeping the blood vessels flexible"
- Oxidative Stress Associated With Acute Abdominal Pain Severity
- Doctor's Guide, 3/22/02 - "Compared to healthy controls, serum from patients presenting with acute
abdominal pain showed lower total antioxidant capacity"
-
The Cleveland Clinic: Eating to Prevent Cancer - WebMD -
"Free radicals are one of the by-products of oxygen use by every cell in our
body. These substances damage the body's cells through oxidation, the same
process that rusts metal and turns butter rancid. Oxidation has also been
shown to contribute to heart disease, cataracts, aging, and infections ...
The body's cells have a natural defense strategy against free radicals and
are able to repair the damage caused by them. However antioxidants, such as
selenium and beta-carotene, help reinforce this protection"
- Antioxidants Shrink Cataract Risk By More Than Half
- Intelihealth, 2/28/02
- Researchers Call Herbs Rich Source Of Healthy Antioxidants; Oregano Ranks
Highest - Intelihealth, 1/7/02 - "Herbs have higher antioxidant activity than fruits, vegetables and some
spices, including garlic ... Wang studied and compared the antioxidant
activity of 39 commonly used herbs grown in the same location and conditions
... the herbs with the highest antioxidant activity belonged to the oregano
family. In general, oregano had 3 to 20 times higher antioxidant activity
than the other herbs studied ... Oregano has 42 times more antioxidant
activity than apples, 30 times more than potatoes, 12 times more than
oranges and 4 times more than blueberries ... herbs have emerged as a quick
and easy way to get a concentrated source of antioxidants - without all the
extra calories of whole foods"
- Intake Of Apples And Selenuim Affects Incidence Of Asthma
- Intelihealth, 12/13/01 - "Eating at least two or more apples per week and a higher intake of the
essential metal selenium can protect against asthma in adults, according to
British researchers ... They reported on a population-based, case-control
study to determine whether asthma is less common and less severe in adults
who consume more dietary antioxidants"
-
Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's
Guide, 11/14/01 - "increasing levels of serum beta- carotene
were associated with significant reductions in systolic
blood pressure, while increasing levels of serum
vitamin C were associated with significant reductions in diastolic
pressure ... In contrast, serum levels of vitamin
E were associated with significant increases in diastolic blood
pressure"
-
Antioxidants Like Vitamin C Soothe Damaging Effects of Pollution -
WebMD, 9/27/01 - "antioxidant
supplements can reduce the harmful effects of ozone gas on our lungs ...
Ozone gas, the main chemical in smog, affects millions of Americans daily,
and previous studies have shown that this highly active gas leads to
decreases in lung function ... the group taking the antioxidant supplements
had higher levels of both vitamins C and E in their blood, but they also saw
that this group had a 25%-30% improvement in lung function tests compared to
those taking placebo"
-
An Apple a Day May Really Keep the Doctor Away, Apples, Tomatoes, and Other
Fruits Offer Lung Protection - WebMD, 5/21/01 - "those who ate more apples and tomatoes had lungs that were, in effect,
three years younger on average than those who ate less fruits and
vegetables"
-
Experiments Extend Life Of Nematode - Intelihealth, 9/1/00
-
Smoking Takes the Power Out of Antioxidants - Nutrition Science News,
8/00
-
Diets High in Antioxidants May Reduce Risk of Alzheimer's Disease -
WebMD, 7/12/00
-
Study Examines Red Wine Antioxidant - Intelihealth, 6/30/00
-
Study Suggests Certain Vitamins Protect Against Deadly Lung Disease -
WebMD, 6/5/00
-
Chocolate: A heart-healthy confection? - CNN, 2/2/00
-
Study Says Apples Help Breathing - Intelihealth, 1/20/00
-
Science takes cellular approach to explore aging process - CNN, 1/4/00
-
Antioxidants Extend Life - Life Enhancement Magazine, 8/99
-
Antioxidants and Aging - Life Extension Magazine, 8/99
- Antioxidants Said Possible Fighter Of Killer Rare Disease
- Intelihealth, 8/17/99
-
Anti-aging nutrition secrets - CNN, 8/4/99
-
Fountain of youth could be in the produce aisle - CNN, 4/5/99
-
Study Finds Vitamin Supplements Could Reduce Hospital Costs By Nearly $20
Billion - Council for Responsible Nutrition
- Antioxidants
May Reduce Harmful Complications Of Diabetes - Doctor's Guide, 4/20/98
- Free Radical
Production Contributes to Cardiovscular Disease In African Americans -
Doctor's Guide, 11/11/97
- Vitamin
Supplements May Reduce Colon Cancer Risk - Doctor's Guide, 11/6/97
-
Report: Only 1 percent of U.S. kids eat properly - CNN, 9/2/97
- Military
Program Proposes Saving Money Through Vitamin Supplementation - Doctor's
Guide, 5/22/97
- Vitamin
Supplements May Help Asthmatics Cope With Air Pollution - Doctor's
Guide, 5/20/97
-
Top Ten
Life Extension Drugs - Life Extension Magazine, 9/95
Abstracts:
-
Dietary
Antioxidant Intake is Associated with the Prevalence but not Incidence of
Age-Related Hearing Loss - J Nutr Health Aging. 2011;15(10):896-900 -
"We aimed to examine the link between dietary and
supplement intakes of antioxidants, and both the prevalence and 5-year incidence
of measured hearing loss ... participants aged 50+ at baseline, examined during
1997-9 to 2002-4 ... Dietary data were collected in a semi-quantitative food
frequency questionnaire ... each standard deviation (SD) increase in dietary
vitamin E intake was associated with a 14% reduced likelihood of prevalent
hearing loss, odds ratio, OR, 0.86 (95% confidence interval, CI, 0.78-0.98).
Those in the highest quintile of dietary vitamin A intake had a 47% reduced risk
of having moderate or greater hearing loss (>40 dB HL) compared to those in the
lowest quintile of intake, multivariable-adjusted OR 0.53 (CI 0.30-0.92), P for
trend = 0.04. However, dietary antioxidant intake was not associated with the
5-year incidence of hearing loss"
-
Antioxidant
Micronutrients Improve Intrinsic and UV-Induced Apoptosis of Human Lymphocytes
Particularly in Elderly People - J Nutr Health Aging. 2011;15(10):912-917 -
"The study was a 2 months, double-blind, randomized
trial. Three age groups were studied: children, young adults and elderly
people. A total of 274 healthy subjects were allocated to a group
supplemented with moderate amounts of retinol, β-carotene, α-tocopherol,
ascorbic acid and selenium or placebo ... Young and elderly people have a
higher intrinsic apoptosis than children, which was improved by antioxidant
supplementation. UV-induced damage was attenuated by the supplementation in
all three age groups"
-
Dietary
total antioxidant capacity and gastric cancer risk in the european
prospective investigation into cancer and nutrition study - Int J
Cancer. 2011 Nov 9 - "A high intake of dietary
antioxidant compounds has been hypothesized to be an appropriate strategy to
reduce gastric cancer (GC) development. We investigated the effect of
dietary Total Antioxidant Capacity (TAC) in relation to GC in the European
Prospective Investigation into Cancer (EPIC) study including 23 centers in
10 European countries ... Dietary antioxidant intake is associated with a
reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI
(0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs.
lowest quintile). The association was observed for both cardia and non
cardia cancers. A clear effect was observed in smokers with a significant
reduction in GC risk for the 5(th) quintile of intake for both assays
(highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for
trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28-0.97) p for trend
<0.001 for TRAP) but not in never smokers. In former smokers the association
with FRAP intake was statistically significant (highest vs. lowest quintile:
adjusted HR 0.4; 95%CI (0.21-0.75) p<0.05); no association was observed for
TRAP"
-
Vitamin,
mineral, and specialty supplements and risk of hematologic malignancies in
the prospective VITamins And Lifestyle (VITAL) study - Cancer Epidemiol
Biomarkers Prev. 2011 Jul 29 - "After adjustment,
high use of garlic supplements (≥4 days/week for ≥3 years; HR=0.55 [95%
confidence interval: 0.34-0.87]; p=0.028 for trend) and ever use of grape
seed supplements (HR=0.57 [0.37-0.88]) were inversely associated with
hematologic malignancies in our models. In addition, high use (8-10
pill-years) of multivitamins was suggestive of an inverse association
(HR)=0.80 [0.64-1.01]). In contrast, no associations were observed for the
remaining supplements ... These data indicate that use of garlic and grape
seed may be associated with reduced risk of hematologic malignancies.Impact:
This is the first cohort study to suggest a possible role of these
supplements in the chemoprevention of hematologic malignancies"
-
Hematological malignancy - Wikipedia, the free encyclopedia -
"Hematological malignancies are the types of
cancer that affect blood, bone marrow, and lymph nodes"
-
French
adults' cognitive performance after daily supplementation with antioxidant
vitamins and minerals at nutritional doses: a post hoc analysis of the
Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) trial -
Am J Clin Nutr. 2011 Jul 20 - "This study included
4447 French participants aged 45-60 y who were enrolled in the SU.VI.MAX
study (1994-2002), which was a double-blind, placebo-controlled, randomized
trial. From 1994 to 2002, participants received daily vitamin C (120 mg),
β-carotene (6 mg), vitamin E (30 mg), selenium (100 μg), and zinc (20 mg) in
combination or as a placebo. In 2007-2009, the cognitive performance of
participants was assessed with 4 neuropsychological tests (6 tasks).
Principal components analysis (PCA) was performed to identify
cognitive-function summary scores. Associations between antioxidant
supplementation and cognitive functions, in the full sample and by
subgroups, were estimated through ANOVA and expressed as mean differences
and 95% CIs. Subgroup analyses were performed according to baseline
characteristics ... Subjects receiving active antioxidant supplementation
had better episodic memory scores (mean difference: 0.61; 95% CI: 0.02,
1.20). PCA indicated 2 factors that were interpreted as showing verbal
memory and executive functioning. Verbal memory was improved by antioxidant
supplementation only in subjects who were nonsmokers or who had low serum
vitamin C concentrations at baseline"
-
Simple sugar, lactate, is like 'candy for cancer cells': Cancer cells
accelerate aging and inflammation in the body to drive tumor growth -
Science Daily, 5/26/11 - "lactate is like "candy"
for cancer cells. And cancer cells are addicted to this supply of "candy."
... We've essentially shown for the first time that there is lactate shuttle
in human tumors ... If lethal cancer is a disease of "accelerated aging" in
the tumor's connective tissue, then cancer patients may benefit from therapy
with strong antioxidants and anti-inflammatory drugs ... Antioxidant therapy
will "cut off the fuel supply" for cancer cells." Antioxidants also have a
natural anti-inflammatory action"
-
Vitamin
supplement use during breast cancer treatment and survival: a prospective
cohort study - Cancer Epidemiol Biomarkers Prev. 2010 Dec 21 -
"Antioxidants may protect normal cells from the
oxidative damage that occurs during radiotherapy and certain chemotherapy
regimens, however, the same mechanism could protect tumor cells and
potentially reduce effectiveness of cancer treatments ... Vitamin use
shortly after breast cancer diagnosis was associated with reduced mortality
and recurrence risk, adjusted for multiple lifestyle factors,
sociodemographics, and known clinical prognostic factors. Women who used
antioxidants (vitamin E, vitamin C, multivitamins) had 18% reduced mortality
risk (hazard ratio (HR) = 0.82, 95% confidence interval (CI): 0.65-1.02) and
22% reduced recurrence risk (HR = 0.78, 95% CI: 0.63-0.95). The inverse
association was found regardless of whether vitamin use was concurrent or
non-concurrent with chemotherapy, but was only present among patients who
did not receive radiotherapy"
-
Differences in antioxidant levels of fresh, frozen and freeze-dried
strawberries and strawberry jam - Int J Food Sci Nutr. 2010 Jun 9 -
"total antioxidant activity (TAA) ... The mean TAA
for freeze-dried strawberries based on an 'as consumed' weight (95%
confidence interval [CI]: 29.58, 30.58) was significantly higher than for
fresh (95% CI: 3.18, 3.66), frozen (95% CI: 2.58, 2.79), and jam (95% CI:
1.10, 1.22). The mean TAA based on dry weight for fresh strawberries (95%
CI: 40.48, 46.67) was significantly higher than for freeze-dried (95% CI:
29.58, 30.58), frozen (95% CI: 24.62, 26.59), and jam (95% CI: 1.48, 1.64).
Results agree with previous studies reporting that strawberries are a
valuable source of antioxidants for consumers"
-
Total
polyphenol excretion and blood pressure in subjects at high cardiovascular
risk - Nutr Metab Cardiovasc Dis. 2010 Feb 16 -
"Participants in the highest quartile of urinary TPE had a reduced
prevalence of hypertension compared to those in the lowest quartile (Odds
Ratio=0.64; 95% confidence interval 0.45 to 0.92; P=0.015). Systolic and
diastolic BP were inversely associated with urinary TPE after adjustment for
potential confounders ... Polyphenol intake, assessed via TPE in urine, was
negatively associated with BP levels and prevalence of hypertension in an
elderly Mediterranean population at high cardiovascular risk. Participants
with the highest intake of polyphenol-rich foods showed the lowest BP
measurements"
-
Intakes
of Vitamin A, C, and E, and beta-Carotene Are Associated With Risk of
Cervical Cancer: A Case-Control Study in Korea - Nutr Cancer.
2010;62(2):181-9 - "Those patients in the highest
quartiles of dietary vitamin A, beta -carotene, and vitamin C intakes had
statistically significantly lower cervical cancer risks than those in the
lowest quartiles for vitamin A, beta -carotene, and vitamin C: odds ratio
(OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI =
0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of
vitamins A, C, and E were strongly inversely associated with cervical cancer
risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53
(CI = 0.28-0.99), respectively. The findings support a role for increased
antioxidant vitamin intake in decreasing the risk of cervical cancer"
-
Antioxidant Treatment With Tempol and Apocynin Prevents Endothelial
Dysfunction and Development of Renovascular Hypertension - Am J
Hypertens. 2009 Sep 24 - "The data suggest that a
compromised mechanism of antioxidant defense and an increase in oxidative
damage contribute to the development of hypertension and associated vascular
dysfunction in 2K-1C rats, and that tempol and apocynin prevent these
effects"
-
Antioxidant vitamins and the risk of endometrial cancer: a dose-response
meta-analysis - Cancer Causes Control. 2009 Jul;20(5):699-711 -
"Based on case-control data, the random-effects
summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98)
per 1,000 mcg/1,000 kcal (I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI:
0.73-0.98) per 50 mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E:
0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
-
Serum
Antioxidants and Skin Cancer Risk: An 8-Year Community-Based Follow-up Study
- Cancer Epidemiol Biomarkers Prev. 2009 Mar 31 -
"basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin
... Although there were no associations between baseline serum carotenoids
or alpha-tocopherol concentrations and incidence of BCC or SCC, baseline
serum selenium concentrations showed strong inverse associations with both
BCC and SCC tumor incidence. Compared with participants with lowest selenium
concentrations at baseline (0.4-1.0 micromol/L), those with the highest
serum selenium concentrations (1.3-2.8 micromol/L) had a decreased incidence
of BCC tumors (multivariate relative risk, 0.43; 95% confidence interval,
0.21-0.86; Ptrend = 0.02) and SCC tumors (multivariate relative risk, 0.36;
95% confidence interval, 0.15-0.82; Ptrend = 0.02)"
-
Antioxidant vitamins and the risk of endometrial cancer: a dose-response
meta-analysis - Cancer Causes Control. 2008 Dec 16 -
"Based on case-control data, the random-effects
summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98)
per 1,000 mcg/1,000 kcal (I(2): 77.7%; p < 0.01); for vitamin C: 0.85 (95%
CI: 0.73-0.98) per 50 mg/1,000 kcal (I(2): 66.1%; p < 0.01); and, for
vitamin E: 0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I(2): 0.0%; p:
0.45)"
-
Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich
Beverages in the United States - J Agric Food Chem. 2008 Jan 26 -
"pomegranate juice (PJ) ... PJ had the greatest
antioxidant potency composite index among the beverages tested and was at
least 20% greater than any of the other beverages tested. Antioxidant
potency, ability to inhibit LDL oxidation, and total polyphenol content were
consistent in classifying the antioxidant capacity of the polyphenol-rich
beverages in the following order: PJ > red wine > Concord grape juice >
blueberry juice > black cherry juice, açaí juice, cranberry juice > orange
juice, iced tea beverages, apple juice. Although in vitro antioxidant
potency does not prove in vivo biological activity, there is also consistent
clinical evidence of antioxidant potency for the most potent beverages
including both PJ and red wine" - See
Pomegranate Juice Extracts at iHerb.
-
Effects of flavonoids and phenolic acids on the inhibition of adipogenesis
in 3T3-L1 adipocytes - J Agric Food Chem. 2007 Oct 17;55(21):8404-10 -
"These results suggest that o-coumaric acid and
rutin targeted for adipocyte functions could be effective in improving the
symptoms of metabolic syndrome"
-
Mortality in randomized trials of antioxidant supplements for primary and
secondary prevention: systematic review and meta-analysis - JAMA. 2007
Feb 28;297(8):842-57
-
Lymphocyte Oxidative DNA Damage and Plasma Antioxidants in Alzheimer Disease
- Archives of Neurology, 5/02 - "Markers of oxidative damage are increased in AD
and correlate with decreased levels of plasma antioxidants. These findings
suggest that lymphocyte DNA 8-OHdG content in patients with AD reflects a
condition of increased oxidative stress related to a poor antioxidant
status"
-
Dietary intake of antioxidants and risk of age-related macular degeneration
- JAMA. 2005 Dec 28;294(24):3101-7 - "In this study, a high dietary intake of beta carotene, vitamins C and E,
and zinc was associated with a substantially reduced risk of AMD in elderly
persons"
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