|
|
|
Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Home > Anti-aging Research > Statins > Zocor
(simvastatin)
Zocor (simvastatin)
Where to purchase:
Related Topics:
News & Research:
-
FDA approves
combination niacin and simvastatin - theheart.org, 2/19/08 -
"The US Food and Drug Administration has approved a
fixed-dose combination of extended-release niacin (Niaspan, Abbot) and
simvastatin ... known as Simcor ... compared with simvastatin 20 mg, the
fixed-dose combination reduced triglyceride levels an additional 27%"
-
Cholesterol-lowering Drug Linked To Sleep Disruptions - Science Daily,
11/7/07 - "The results showed that simvastain use
was associated with significantly worse sleep quality. A significantly
greater number of individuals taking simvastatin reported sleep problems
than those taking either pravastain or the placebo"
-
Cholesterol Drug May Affect Sleep - WebMD, 11/7/07
-
Combination Niacin-Laropiprant Plus Simvastatin Reduces Cholesterol by
Almost 50% - Doctor's Guide, 11/6/07 - "When
patients with dyslipidemia added simvastatin to their experimental
combination of extended-release niacin and
laropiprant -- a novel anti-flushing agent -- they reported reductions in
low density lipoprotein cholesterol (LDL-C) of as much as 48% from baseline
... high density liopoprotein cholesterol (HDL-C) was increased by 28% and
triglycerides decreased by 33%"
-
Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's
Weekly Article, 10/15/07 - "there appears to be a
strong reduction in dementia and Parkinson’s disease incidence attributed to
the use of simvastatin, a cholesterol lowering drug. The researchers also
observed a moderate reduction in incidence of these conditions with
atorvastatin, another cholesterol-lowering drug"
-
Cholesterol Drug Change May Be Risky - WebMD, 9/5/07 -
"Compared with the patients who remained on Lipitor,
those who switched to simvastatin were 43% more likely to suffer from a
major cardiovascular event such as heart attack or stroke. They were twice
as likely to suffer strokes, and 36% more likely to have heart attacks"
-
Zocor vs. Alzheimer's and Parkinson's - WebMD, 7/18/07 -
"In patients over age 64, those who took Zocor were
54% less likely to get Alzheimer's disease and 49% less likely to get
Parkinson's disease than were matched patients not taking statin drugs ...
Those who took Lipitor were 9% less likely to get Alzheimer's disease"
-
Statin Treatment Improves Spatial Memory In Mouse Models Of Alzheimer's
- Science Daily, 4/30/07 -
"Treatment with Simvastatin, one of the statin drugs widely used for
lowering cholesterol in humans, significantly improved spatial memory - how
to navigate a water maze - in mice genetically bred to have an Alzheimer's
like disease"
-
Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High
Cardiovascular-Risk Patients With Elevated High Sensitivity C-Reactive
Protein: The PIOSTAT Study - Medscape, 1/9/07 -
"After 12 weeks of treatment, hs-CRP
levels were reduced from 3.64 ±2.42 mg/l to 2.48 ±1.77 mg/l with
pioglitazone monotherapy and from 3.26 ±2.02 mg/l to 2.81 ±2.11 mg/l with
simvastatin monotherapy (as illustrated in Fig. 1). Combination treatment
with pioglitazone and simvastatin resulted in an additive decrease in hs-CRP
levels from 3.49 ±1.97 mg/l to 2.06 ±1.42 mg/l after 12 weeks"
-
Simvastatin May Cut Alzheimer's, Parkinson's Risk - Clinical Psychiatry
News, 12/06 - "Simvastatin use for
at least 7 months reduced the incidence of Alzheimer's disease by 30% and
Parkinson's disease by 24% in older people ... Neither lovastatin nor
atorvastatin provided similar benefits"
-
Researchers Find Added Benefit of Statins in Those at High Risk for Heart
Disease, Diabetes - Doctor's Guide, 9/13/06 -
"found marked reductions in two
pivotal biomarkers of inflammation: C-reactive protein (CRP) and
interleukin-6. While these markers are typically elevated in insulin
resistance, a condition that precedes the development of diabetes, statin
therapy reduced these levels by 36% and 44%, respectively"
-
Atorvastatin More Effective Than Simvastatin in Cutting Risk of Additional
Heart Attacks in Patients Who Had a Recent Heart Attack, New Data Suggests
- Doctor's Guide, 9/6/06
-
FDA OKs 1st Generic Version of Zocor - WebMD, 6/23/06 -
"The first generic version of the
cholesterol-lowering statin drug Zocor has been approved by the FDA"
-
Erectile Dysfunction and Statin Treatment - Medscape, 3/21/06 -
"Simvastatin was found to cause
impotency in five men with coronary artery disease, and within 1 week of
discontinuing simvastatin, sexual function was restored. The Australian
Adverse Drug Reactions Committee reported 42 cases of ED associated with
simvastatin.[13] In contrast, in one study in men aged 49.7 years and
isolated hypercholesterolaemia [low-density lipoprotein (LDL)-C 4.3 mmol/l]
as a risk factor which used penile Doppler ultrasound in a per protocol
analysis of 50% of the cohort of 18 patients (n = 9), atorvastatin therapy
was associated with improvement in erectile function"
-
Simvastatin and Depression - Medscape, 1/20/06
-
Simvastatin Improves Metabolic Profile and Clinical Symptoms Associated with
Polycystic Ovary Syndrome - Doctor's Guide, 10/20/05
-
Rhabdomyolysis from Simvastatin Triggered by Infection - Medscape,
9/8/05
-
MRI Scan Reveals How Cholesterol Drugs Work - WebMD, 7/5/05 -
"20 milligrams or 80 milligrams of
Zocor daily ... After a year and a half of treatment, MRI scans showed that
both groups ended up with similar reductions in plaque size, regardless of
the strength of their statin dose ... Reduction in the size of blood vessel
wall plaque was greater in people whose LDL cholesterol dropped below 100
mg/dl"
-
Statins Do More Than Lower Cholesterol - HealthDay, 4/2/05 -
"A new study in diabetic rats
suggests that statin treatment also prevents or reverses damage to the
delicate endothelial cells that line arteries"
-
Simvastatin Appears Safe and Effective for PCOS Patients - Medscape,
3/25/05
-
Vytorin Slashes Bad Cholesterol to Lower Levels Than Atorvastatin -
Doctor's Guide, 3/9/05
-
Cholesterol-lowering drugs have a long-term effect - US News, 12/3/04 -
"Patients who'd taken simvastatin during the five-year trial were
still better off five years after the trial ended. (In this case, "better off" means "more likely to be alive.")"
- Statins May Lower Blood Pressure - Doctor's Guide, 11/20/04 -
"simvastatin
was associated with a 2.79-mm Hg decrease in systolic blood pressure and a 2.67-mm Hg drop in diastolic blood pressure, while pravastatin led to a 2.47-mm Hg decline in systolic blood pressure and a 2.47-drop in diastolic blood pressure"
- Simvastatin Demonstrates Benefits in Patients With Chronic Renal Insufficiency - Doctor's Guide, 11/1/04
- Simvastatin's Benefits May Extend to Atherosclerotic Plaque Stabilisation in Diabetics - Doctor's Guide, 10/25/04 -
"Simvastatin-dependent
plaque stabilisation in patients with type 2 diabetes arises from the drug's ability to decrease expression of receptor for advanced glycation end products (RAGE),
and thence to reduce metalloproteinase (MMP) activity, and promote plaque stabilisation"
- Is Lower Really Better for Cholesterol? - WebMD, 9/14/04 -
"The National Cholesterol Education Program (NCEP)
reduced target LDL levels from 100 mg/dL to 70 mg/dL for those at the very highest risk of heart disease
... high-dose Lipitor decreased CRP by 38%, while high-dose Zocor reduced CRP by just 17% in the current study"
- Why Some Statins Work Better - Time Magazine, 9/13/04 -
"patients taking high doses of Zocor fared no better than a low-dose group in terms of
heart-attack risk, despite low LDL levels. Why? Perhaps because Lipitor works not just by lowering cholesterol but also by reducing inflammation, something Zocor can't do as well"
- Cholesterol Drug Goes Over-the-Counter - WebMD, 7/29/04
- New Cholesterol Drug Poised for U.S. Market - WebMD, 7/22/04 -
"The drug, called Vytorin,
is the first of its kind, combining a popular drug, Zocor, from a class known as statins, with a non-statin medication, Zetia, in a single pill"
- No Clear-Cut Answers on Statins as Therapy for Alzheimer's Disease - Doctor's Guide, 7/19/04 -
"Alzheimer mice treated
with simvastatin regain their ability to navigate mazes"
- Simvastatin and Niacin Well Tolerated in Patients With or Without Diabetes - Doctor's Guide, 4/13/04
- Statins Effectively Lower Cholesterol, But Experts Debate First Choice - Medscape, 3/15/04 -
"HDL cholesterol levels were increased more than 10% with
rosuvastatin 40 mg, nearly 5% with atorvastatin 80 mg, 10% with 40 mg simvastatin, and 6.4% with 40 mg pravastatin"
- Lipid-Lowering Combination May Be More Effective Than High-Dose Atorvastatin - Medscape, 3/12/04 -
"The coadministration
of ezetimibe plus simvastatin provided additional improvements in lipid profiles across a wide range of doses compared with titration of atorvastatin monotherapy"
- Simvastatin/Ezetimibe Combination Outperforms High Dose Atorvastatin in Lowering Cholesterol - Doctor's Guide, 3/9/04
- Ezetimibe Plus Simvastatin Reduces C-Reactive Protein Levels - Doctor's Guide, 11/14/03
- Zetia (Ezetimibe) Plus Simvastatin Provided More than Twice the Reduction of C-reactive protein in Patients with High Cholesterol Compared to Simvastatin Alone - Doctor's Guide,
11/13/03 - "CRP is considered an emerging risk marker for CHD ...
Zetia with simvastatin reduced levels of the marker CRP by 33.3 percent compared to simvastatin
administered alone (14.3 percent ... In addition, patients taking Zetia co-administered with simvastatin experienced an LDL cholesterol (LDL-C) reduction of 45 to 60 percent across the dosage range, compared to a reduction of 31 to 44 percent in
patients taking simvastatin alone"
- Intravascular Ultrasound Depicts Coronary Artery Plaque Regression With Simvastatin - Doctor's Guide, 11/12/03 -
"Lipid-lowering therapy with simvastatin for 12 months is associated with a significant plaque regression ... the plaque regression -- about 6.3% from baseline"
- Simvastatin Increases HDL-C And Apo A-I More Than Atorvastatin in Patients With Hypercholesterolemia - Doctor's Guide, 11/10/03 -
"Simvastatin
appears to increase high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I significantly more than does atorvastatin in patients with
hypercholesterolaemia ... Liver toxicity occurred in significantly fewer patients treated with simvastatin compared to atorvastatin"
- Combination Treatment of Ezetimibe and Simvastatin Safe and Effective - Doctor's Guide, 10/3/03 -
"The combined administration of ezetimibe 10
mg/dL and simvastatin 5 mg to 80 mg/dL is well tolerated and effective in allowing patients with primary hypercholesterolaemia to
attain the recommended low-density lipoprotein (LDL) cholesterol levels ... ezetimibe is a cholesterol absorption inhibitor that blocks the transport of dietary and biliary
cholesterol across the intestinal wall"
- Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
"Rosuvastatin significantly more
effective than atorvastatin, simvastatin, and pravastatin in improving the ratios of total cholesterol to high-density lipoprotein cholesterol" - See
Crestor (rosuvastatin)
 at drugstore.com.
- Statins Used to Treat High Cholesterol and Osteoporosis - Doctor's Guide, 9/30/03 -
"simvastatin acts as a double therapeutic weapon by blocking
the conversion of HMG-CoA to mevalonate. Not only does this action increase new bone formation via the stimulation of osteoblasts, but it also prevents the production of cholesterol" - See Zocor
(simvastatin)
 at drugstore.com.
- Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol - Doctor's Guide, 9/30/03 -
"Most significantly, while the PWV remained
unchanged in the pravastatin and non-statin group, it was moderately decreased in the simvastatin group and remarkably reduced in the fluvastatin group ... Dr. Ichihara theorized that lipophilic statins, such as fluvastatin, reduce aortic stiffness via three mechanisms
-- decreasing serum total cholesterol levels without reducing serum high-density lipoprotein levels, providing powerful scavenging reactive oxygen species, as well as reducing serum levels of low-density lipoprotein and C-reactive protein" - See
Zocor (simvastatin),
Pravachol (pravastatin)
 and
Lescol (fluvastatin) at drugstore.com.
- Statins may play a role in the treatment of inflammatory rheumatic diseases - Doctor's Guide, 9/28/03 -
"the administration of simvastatin for 8
days was associated with a rapid and significant reduction in proteinuria levels in the three patients with SLE, as well as in the 2 patients with systemic vasculitis. In the five patients with RA, atorvastatin for 8 days was associated with a
reduction in C-reactive protein levels and clinical improvement ... statins may have an important therapeutic potential for different inflammatory diseases"
- Heart Protection Study Implications for Lipid Management Guidelines and Practices - Doctor's Guide, 9/16/03 -
"While Heart Protection Study (HPS) findings support
aggressive lowering of low-density lipoprotein (LDL) cholesterol levels and suggest optimal levels well below current recommendations, failure to achieve current goals for LDL cholesterol is common ... HPS findings demonstrated that a reduction of major vascular events extended even to CAD patients with initial LDL
cholesterol levels <100 mg/dL using simvastatin 40 mg, suggesting that the optimal LDL cholesterol level is below target levels established in current guidelines ... rosuvastatin is more effective than other statins in reducing LDL cholesterol"
- Statins Benefit Diabetics, Regardless of Cholesterol Levels - Medscape, 8/13/03 -
"These results show that simvastatin therapy leads to significant risk reductions for vascular
events in type 2 diabetic patients, even if they don't have diagnosed coronary disease or high cholesterol levels. The authors estimate that 5 years of treatment would prevent about 45 major vascular events per 1000 patients and suggest that statins should be offered to high-risk diabetic patients regardless of
their cholesterol levels"
- Statins Help Ease Heart Failure - WebMD, 7/28/03 -
"People with heart failure may benefit from treatment with cholesterol-lowering statin drugs even if their cholesterol
levels are normal ... One group took 5 mg of the statin Zocor for four weeks followed by 10 mg for 10 weeks ... standard dose of Zocor in the U.S. to treat high cholesterol is 40 mg ... researchers found significant improvements among the patients taking the statin. Their average level of functional heart impairment
dropped from 2.39 to 2.04 on a scale of 1 to 4 ... left ventricular ejection fraction, a measure of heart function, rose from 34% to 41%"
- Simvastatin May Retard Progression of Severe White Matter Changes - Doctor's Guide, 5/26/03 -
"Simvastatin may slow down the progression of
severe white matter changes in the brain, and may therefore retard cognitive decline ... The most common type of vascular dementia is due to the hardening of the arteries deep inside the brain which causes white matter changes... and
its been shown that this can lead to executive dysfunction"
- Simvastatin Therapy Slows Coronary Disease Progression in Patients With and Without Cardiovascular Risk Factors - Doctor's Guide, 5/22/03 -
"simvastatin/enalapril
therapy versus placebo resulted in decreases in mean coronary artery diameters ... and minimum diameters ... study results support the contention that the therapeutic effect of statin lipid lowering drugs on angiographically seen coronary atherosclerosis is linked to the reduction of coronary events without regard
to the presence of known cardiovascular risk factors"
- Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High Cholesterol - Doctor's Guide, 4/4/03 -
"C-reactive
protein is considered an emerging risk factor and risk marker for coronary heart disease ... the levels of C-reactive protein were about halved when the pooled ezetimibe plus simvastatin results were compared with simvastatin alone. The combination
produced about a 34.8% reduction compared to an 18.2% reduction if the statin was used as monotherapy"
- Statin Appears Promising for MS - Medscape, 4/2/03
- Zocor for Multiple Sclerosis Treatment - WebMD, 4/2/03
- Ezetimibe Plus Simvastatin Safely Improves Lipid Profile - Doctor's Guide, 1/17/03 -
"Ezetimibe and simvastatin given together reduced
low-density lipoprotein cholesterol by 44 to 57%, reduced triglycerides by 20 to 28% and raised high-density lipoprotein cholesterol by 8 to 11%, depending on the simvastatin dose"
- Atorvastatin, Simvastatin Effects Similar For Subclinical Atherosclerosis - Doctor's Guide, 1/7/03
- Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For Hyperlipidemia - Doctor's Guide, 12/24/02 -
"One group received 3.5 grams of
ispaghula husk twice a day and the second group received 20 milligrams of simvastatin each day ... total cholesterol decreased by 15.8 percent and low-density lipoprotein (LDL) cholesterol
decreased by 22.97 percent among patients taking ispaghula husk ... Triglycerides decreased by 20.89 percent and high-density lipoprotein (HDL) cholesterol increased by 10.69 percent in these patients
... Among patients taking simvastatin, total cholesterol decreased by 24.15 percent, LDL cholesterol decreased by 36.08 percent, triglycerides decreased by 20.47 percent and HDL cholesterol increased by 11.4 percent" - I've got that. See
Drugstore.com psyllium products
 . 3.5 grams is about one wafer (3.4
grams psyllium/wafer). Plus 24 wafers runs about $4.49 versus about
$116 for 30 of the 20 mg simvastatin.
- Simvastatin Increases HDL and Apo-A1 Better Than Atorvastatin - Doctor's Guide, 9/13/02
- Early Simvastatin Therapy Improves Endothelial Function - Doctor's Guide, 9/13/02
- Simvastatin Protects against Endothelial Dysfunction in Type 2 Diabetes - Doctor's Guide, 9/5/02
- Simvastatin Improves Cholesterol Profile more than Atorvastatin in the Metabolic Syndrome - Doctor's Guide, 9/4/02
- Zocor (Simvastatin) Saves Lives In High-Risk Patients, Regardless Of Cholesterol Level, Study In Lancet Shows - Diabetics, Women, Elderly Benefit In Largest Cholesterol Study Ever -
Doctor's Guide, 7/5/02 - "simvastatin given daily at 40 mg reduced the risk of heart attack and stroke by about one-fourth over the treatment period, which averaged 5.3 years ... When adjusted for
non-compliance (inadvertent or deliberate failure to take medication) in the trial, investigators estimate that the risk reduction among this broad population is one-third ... Not only did we find that cholesterol-lowering treatment can protect a far wider range of people than was previously thought, but that the
therapy we used in the study can prevent stroke as well as heart attack, in patients at risk of CHD even in people with already moderate or low cholesterol levels ... Patients with average or low cholesterol levels also achieved CHD risk reductions of about a quarter. When adjusted for non-compliance, Oxford
researchers estimate that the risk of heart attack and stroke in this group would be reduced by one-third"
- WelChol (colesevelam HCl)/Zocor (simvastatin) Combo Better Than Zocor Alone - Doctor's Guide, 4/30/01 -
"Treatment with WelChol (3.8 grams daily) decreased LDL-cholesterol levels
by 16 percent, and Zocor (10 milligrams daily) reduced mean LDL-cholesterol levels by 26 percent; the combination appeared to be additive, with a 42 percent reduction"
- Atorvastatin Better than Simvastatin for Achieving Total Cholesterol Targets - Doctor's Guide, 4/12/00
- Zocor (Simvastatin) Increases HDL And apo A-I More Than Lipitor (Atorvastatin) - Doctor's Guide, 3/15/00
- Study Shows Significant Difference Between Two Statins In Raising HDL - Doctor's Guide, 8/25/98
Abstracts:
-
Simvastatin induces apoptosis in human colon cancer cells and in tumor
xenografts, and attenuates colitis-associated colon cancer in mice - Int
J Cancer. 2008 Jun 2 - "colitis-associated colon
cancer (CAC) ... simvastatin could be a potential chemopreventive and
therapeutic agent of CAC as well as de novo colon cancer"
-
Comparison of the Safety and Efficacy of a Combination Tablet of Niacin
Extended Release and Simvastatin vs Simvastatin Monotherapy in Patients With
Increased Non-HDL Cholesterol (from the SEACOAST I Study) - Am J Cardiol.
2008 May 15;101(10):1428-36 - "The efficacy and
safety of 2 regimens of a combination of a proprietary niacin extended
release plus simvastatin (NER/S; 1,000/20 and 2,000/20 mg/day) were compared
with simvastatin monotherapy (20 mg/day) for 24 weeks ... The safety of
NER/S was consistent with the safety profile of each individual component.
In conclusion, this study showed that NER/S provided additional clinically
relevant improvements in multiple lipid parameters and was safe and well
tolerated"
-
High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention
After Myocardial Infarction - JAMA. 2005;294:2437-2445
-
Effectiveness of simvastatin therapy in raising HDL-C in patients with type 2 diabetes and low HDL-C - Curr Med Res Opin. 2004 Jul;20(7):1087-94
- "Both simvastatin 80 and 40 mg significantly increased total HDL-C from baseline (mean increases of 8%"
- Simvastatin and impotence - BMJ 1997;315:31 (5 July)
Related Searches:
70706
|
