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Home > Anti-aging Research > Hesperidin
Hesperidin
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News & Research:
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Citrus extracts show energy burning potential, without side effects: Study
- Nutra USA, 5/17/11 - "consumption of 100 mg
hesperidin, 50 mg p-synephrine (from bitter orange), and 600 mg naringin
increased the resting metabolic rate by about 18 percent ... If one assumes
that the product was taken twice a day for one year, the theoretical
increase in calorie consumption would amount to over 31 pounds ... None of
the treatment groups exhibited changes in heart rate or blood pressure
relative to the control group, nor there were no differences in
self-reported ratings of 10 symptoms between the treatment groups and the
control group ... the thermogenic effect of p-synephrine may be increased by
naringin and hesperidin via an enhancement in the production of the
expression of adiponectin, a hormone released from fat cells, which plays an
important role in the regulation of insulin sensitivity and energy" -
[Abstract]
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Orange juice flavanone may benefit heart health: Study - Nutra USA, 12/17/10
- "The researchers reported that blood pressure was significantly lowered after
4 weeks consumption of orange juice or a hesperidin rich drink when compared to
a placebo drink" - [Abstract]
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Daily Glass of Orange Juice Is Heart Smart - WebMD, 7/20/09 -
"An antioxidant in orange juice called hesperidin
improves blood vessel function and helps lower a person’s risk of heart
disease ... An antioxidant in orange juice called hesperidin improves blood
vessel function and helps lower a person’s risk of heart disease"
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Citrus flavanones show neuroprotection potential - Nutra USA, 1/21/08 -
"These results first demonstrate that the citrus
flavanones hesperidin, hesperetin, and neohesperidin, even at physiological
concentrations, have neuroprotective effects against H2O2-induced
cytotoxicity in PC12 cells ... These dietary antioxidants are potential
candidates for use in the intervention for neurodegenerative diseases ...
One such disease that is mentioned Alzheimer's disease" - [Abstract]
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Citrus extracts get cholesterol-lowering boost - Nutra USA, 3/26/07
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Men's Fitness: Boost your good cholesterol sky-high: want to live longer?
Try raising this cholesterol with our 10 strategies - findarticles.com,
2/02 - "In a Canadian study,
drinking a few glasses of orange juice every day for four weeks increased
participants' HDL by 21 percent, possibly due to a flavonoid called
hesperidin that appears extremely HDL-friendly"
- High Levels of HDL Cholesterol Can Save Your Life - ABC News, 11/3/00 -
"So how much HDL is enough? Current guidelines say 35 milligrams per deciliter of blood (mg/dl) is
normal, but most cardiologists would prefer you to have an HDL count that’s twice that. “The higher the better,” says Gaziano. “Once you get over 60 mg/dl, it’s a strong positive factor in avoiding heart disease.” ... this will increase your HDL by 21 percent (or 10 to 20 points) within 4 weeks. “We’re not sure, but
this effect may be due to a flavonoid in orange juice called hesperidin"
- Herbal Treatment for Varicose Veins - Nutrition Science News, 7/00
Abstracts:
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Citrus
Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells
while Improving Endothelial Function and Reducing Inflammatory Markers in
Patients with Metabolic Syndrome - J Clin Endocrinol Metab. 2011 Feb 23 -
"Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular
actions relevant to their health benefits ... Treatment of BAEC with hesperetin
acutely stimulated phosphorylation of Src, Akt, AMP kinase, and endothelial NO
synthase to produce NO; this required generation of H(2)O(2). Increased adhesion
of monocytes to BAEC and expression of vascular cell adhesion molecule-1 in
response to TNF-α treatment was reduced by pretreatment with hesperetin. In the
clinical study, when compared with placebo, hesperidin treatment increased
flow-mediated dilation (10.26 ± 1.19 vs. 7.78 ± 0.76%; P = 0.02) and reduced
concentrations of circulating inflammatory biomarkers (high-sensitivity
C-reactive protein, serum amyloid A protein, soluble E-selectin). Conclusions:
Novel mechanisms for hesperetin action in endothelial cells inform effects of
oral hesperidin treatment to improve endothelial dysfunction and reduce
circulating markers of inflammation in our exploratory clinical trial.
Hesperetin has vasculoprotective actions that may explain beneficial
cardiovascular effects of citrus consumption"
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Hesperidin contributes to the vascular protective effects of orange juice: a
randomized crossover study in healthy volunteers - Am J Clin Nutr. 2010
Nov 10 - "Throughout the three 4-wk periods,
volunteers consumed daily 500 mL orange juice, 500 mL control drink plus
hesperidin (CDH), or 500 mL control drink plus placebo (CDP) ... Diastolic
blood pressure (DBP) was significantly lower after 4 wk consumption of
orange juice or CDH than after consumption of CDP (P = 0.02), whereas
microvascular endothelium-related reactivity was not significantly affected
when measured after an overnight fast. However, both orange juice and CDH
ingestion significantly improved postprandial microvascular endothelial
reactivity compared with CDP (P < 0.05) when measured at the peak of plasma
hesperetin concentration"
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Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced
Cytotoxicity in PC12 Cells - J Agric Food Chem. 2008 Jan 12 -
"the citrus flavanones hesperidin, hesperetin, and
neohesperidin, even at physiological concentrations, have neuroprotective
effects against H 2O 2-induced cytotoxicity in PC12 cells. These dietary
antioxidants are potential candidates for use in the intervention for
neurodegenerative diseases" - See
Hesperidin products at iHerb
 .
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Hesperidin, a Citrus Flavonoid, Inhibits Bone Loss and Decreases Serum and Hepatic Lipids in Ovariectomized Mice - J. Nutr. 133:1892-1897, June 2003 -
"These results suggest a possible role for citrus flavonoids in the prevention of lifestyle-related diseases because of their beneficial effects on bone and lipids"
- Biological effects of hesperidin, a Citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat
- Farmaco. 1995 Sep;50(9):595-9 - "Hesperidin, the most important flavanone of Citrus sp., significantly increases HDL"
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