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Anti-aging Research > Vitamin C
News & Research:
Can Vitamin C Ward Off Stroke? - WebMD, 2/14/14 -
"Vannier's team looked at 65 people who had suffered
a hemorrhagic stroke, comparing them with 65 healthy people ... On average,
those who had a stroke had depleted levels of vitamin C, while vitamin C
levels were normal in the healthy individuals ... Depleted levels of vitamin
C was linked to longer hospitalizations, but not a higher risk of death ...
Vitamin C levels were significantly lower in people who had brain bleeds,
compared with healthy people, but we have not yet calculated an odds risk"
Vitamin C may be beneficial against exercise-induced bronchoconstriction
- Science Daily, 6/12/13 - "Exercise-induced
bronchoconstriction means the transient narrowing of the airways that occurs
during or after exercise. It can cause symptoms such as cough, wheezing and
the shortness of breath. Formerly, this condition was called
exercise-induced asthma ... About 10% of the general population suffers from
exercise-induced bronchoconstriction, but among some fields of competitive
winter sports the prevalence can be up to 50% ... The pooled estimate of
vitamin C effect indicated a 48% reduction in the FEV1 decline caused by
exercise" - See
vitamin C products at Amazon.com.
Vitamin C can kill drug-resistant TB, researchers find - Science Daily,
5/21/13 - "vitamin C kills drug-resistant
tuberculosis (TB) bacteria in laboratory culture. The finding suggests that
vitamin C added to existing TB drugs could shorten TB therapy"
Vitamin C may head off lung problems in babies born to pregnant smokers
- Science Daily, 5/4/13 - "If a woman absolutely
can't kick the habit, taking vitamin C during pregnancy may improve her
newborn's lung function and prevent wheezing in the first year of life ...
Specifically, 21 percent of infants in the vitamin C group had at least one
episode of wheezing compared to 40 percent of those in the placebo group and
27 percent of infants born to nonsmokers. In addition, 13 percent of infants
whose mothers were randomized to vitamin C needed medication for their
wheezing compared to 22 percent of infants in the placebo group and 10
percent in the nonsmoking group" - Err!! Why would pregnant women
smoke to begin with?
Vitamin C is beneficial against the common cold, review suggests -
Science Daily, 2/13/13 - "Regular doses of vitamin C
of one gram per day or higher have reduced the average duration of colds in
adults by 8% and in children by 18%"
Fetus suffers when mother lacks vitamin C - Science Daily, 11/16/12 -
"Maternal vitamin C deficiency during pregnancy can
have serious consequences for the fetal brain. And once brain damage has
occurred, it cannot be reversed by vitamin C supplements after birth ...
Even marginal vitamin C deficiency in the mother stunts the fetal
hippocampus, the important memory centre, by 10-15 per cent, preventing the
brain from optimal development"
Vitamin C prevents bone loss in animal models - Science Daily, 10/9/12 -
"What this study shows is that large doses of
vitamin C, when ingested orally by mice, actively stimulate bone formation
to protect the skeleton. It does this by inducing osteoblasts, or premature
bone cells, to differentiate into mature, mineralizing specialty cells."
Vitamin C and beta-carotene might protect against dementia - Science
Daily, 9/11/12 - "A total of 74 AD-patients and 158
healthy controls were examined for the study that has been published in the
Journal of Alzheimer's Disease (JAD) ... The concentration of vitamin C and
beta-carotene in the serum of AD-patients was significantly lower than in
the blood of control subjects. Whereas no such difference between the groups
could be found for the other antioxidants (vitamin E, lycopene, coenzyme
Q10)" - See
Jarrow Formulas, CarotenALL at Amazon.com
vitamin C products at Amazon.com.
Vitamin C may lessen harmful effects of air pollution- USA Today,
8/17/12 - "Results showed that with every increase
in course particulate matter of 10 micrograms per cubic meter (mcg/m3),
there was a 35 percent increased risk of hospital admission for people with
asthma or COPD ... However, the risk of admission was 1.2 times greater
among people with low levels of vitamin C"
Increased recommended dietary Vitamin C could help reduce heart disease,
stroke, cancer - Science Daily, 7/16/12 - "The
recommended dietary allowance, or RDA, of vitamin C is less than half what
it should be, scientists argue in a recent report, because medical experts
insist on evaluating this natural, but critical nutrient in the same way
they do pharmaceutical drugs and reach faulty conclusions as a result ...
the RDA of vitamin C should be raised to 200 milligrams per day for adults,
up from its current levels in the United States of 75 milligrams for women
and 90 for men ... Rather than just prevent the vitamin C deficiency disease
of scurvy, they say, it's appropriate to seek optimum levels that will
saturate cells and tissues, pose no risk, and may have significant effects
on public health at almost no expense ... higher levels of vitamin C could
help reduce the chronic diseases that today kill most people in the
developed world -- heart disease, stroke, cancer, and the underlying issues
that lead to them, such as high blood pressure, chronic inflammation, poor
immune response and atherosclerosis"
doses of vitamin C may lower blood pressure - Science Daily, 4/18/12 -
"Miller and his colleagues reviewed and analyzed
data from 29 randomized, controlled, previously published clinical trials
that reported systolic and/or diastolic blood pressure values and also
compared vitamin C intake to a placebo. What they found is that taking an
average of 500 milligrams of vitamin C daily -- about five times the
recommended daily requirement -- reduced blood pressure by 3.84 millimeters
of mercury in the short term. Among those diagnosed with hypertension, the
drop was nearly 5 millimeters of mercury ... By comparison, Miller says,
patients who take blood pressure medication such as ACE inhibitors or
diuretics (so-called "water pills") can expect a roughly 10 millimeter of
mercury reduction in blood pressure" - Note: I don't consider 500 mg
Treatment with vitamin C dissolves toxic protein aggregates in Alzheimer's
disease - Science Daily, 8/18/11 - "The brains
of people with Alzheimer's disease contain lumps of so-called amyloid
plaques which consist of misfolded protein aggregates. They cause nerve cell
death in the brain and the first nerves to be attacked are the ones in the
brain's memory centre ... When we treated brain tissue from mice suffering
from Alzheimer's disease with vitamin C, we could see that the toxic protein
aggregates were dissolved ... The notion that vitamin C can have a positive
effect on Alzheimer's disease is controversial, but our results open up new
opportunities for research into Alzheimer's and the possibilities offered by
Scientists discover new role for vitamin C in the eye and the brain -
Science Daily, 7/15/11 - "cells in the retina need
to be 'bathed' in relatively high doses of vitamin C, inside and out, to
function properly ... Because the retina is part of the central nervous
system, this suggests there's likely an important role for vitamin C
throughout our brains, to a degree we had not realized before ... The
findings could have implications for other diseases, like glaucoma and
epilepsy. Both conditions are caused by the dysfunction of nerve cells in
the retina and brain that become over excited in part because GABA receptors
may not be functioning properly"
Vitamin C may offer potential life-saving treatment for sepsis - Science
Daily, 11/17/10 - "vitamin C can not only prevent
the onset of sepsis, but can reverse the disease"
Vitamin C rapidly improves emotional state of acutely hospitalized patients,
study suggests - Science Daily, 9/23/10 -
"Treatment with vitamin C rapidly improves the emotional state of acutely
hospitalized patients ... About one in five acute-care patients in our
hospital have vitamin C levels so low as to be compatible with scurvy ...
But patients are rarely given vitamin supplements. Most physicians are
simply unaware of the problem"
Omega-3, vitamins C and E may boost pancreatic health - Nutra USA,
"consuming at least 850 milligrams of omega-3 fatty
acids per day was associated with a 53 percent reduction in the risk of
pancreatic cancer, compared to intakes of between 330 and 580 milligrams per
day ... According to findings published in the International Journal of
Cancer, benefits were also observed for intakes of vitamin C and E, the
highest average intakes associated with 31 and 33 percent reductions,
respectively, compared with the lowest average intakes" - [Abstract]
Citrus surprise: Vitamin C boosts the reprogramming of adult cells into stem
cells - Science Daily, 12/29/09 - "The
researchers found that adding vitamin C, an essential nutrient that is
abundant in citrus fruits, enhanced iPSC generation from both mouse and
human cells. Vitamin C accelerated gene expression changes and promoted a
more efficient transition to the fully reprogrammed state. Somewhat to their
surprise, they found that other antioxidants do not have the same effect,
but vitamin C does seem to act at least in part through slowing cell
senescence ... It is also of interest that a vitamin with long-suspected
anti-aging effects has such a potent influence on reprogramming, which can
be considered a reversal of the aging process at the cellular level"
Antioxidant compound reduced incidence of colorectal metachronous adenomas
- Science Daily, 12/7/09 - "The researchers
randomized 411 participants to the placebo group or to receive an
antioxidant compound -- specifically selenomethionnine 200 μg, zinc 30 mg,
vitamin A 6,000 IU, vitamin C 180 mg and vitamin E 30 mg ... individuals who
consumed antioxidants had a 40 percent reduction in the incidence of
metachronous adenomas of the large bowel ... It is noteworthy that the
benefit observed after the conclusion of the trial persisted through 13
years of follow up"
Role Of Vitamin C In Skin Protection; Relevance To The Cosmetics Industry
- Science Daily, 9/8/09 - "a form of Vitamin C
helped to promote wound healing and also helped protect the DNA damage of
skin cells ... Previously, the group has published evidence that DNA repair
is upregulated in people consuming vitamin C supplements ... The results
demonstrated that vitamin C may improve wound healing by stimulating
quiescent fibroblasts to divide and by promoting their migration into the
wounded area. Vitamin C could also protect the skin by increasing the
capacity of fibroblasts to repair potentially mutagenic DNA lesions ... Free
radicals are associated with premature skin aging, and antioxidants, such as
vitamin C, are known to counter these highly damaging compounds. This new
evidence suggest that, in addition to ‘mopping up’ free radicals, vitamin C
can help remove the DNA damage they form, if they get past the cell’s
Vitamin C Deficiency Impairs Early Brain Development, Guinea Pig Study Finds
- 9/4/09 - "guinea pigs subjected to moderate
vitamin C deficiency have 30 per cent less hippocampal neurones and markedly
worse spatial memory than guinea pigs given a normal diet. Like guinea pigs,
human beings are dependent on getting vitamin C through their diet, and Jens
Lykkesfeldt therefore speculate that vitamin C deficiency in pregnant and
breast-feeding women may also lead to impaired development in foetuses and
Stopping Diabetes Damage With Vitamin C - Science Daily, 6/10/09 -
"While neither therapy produced desired results when
used alone, the combination of insulin to control blood sugar together with
the use of Vitamin C, stopped blood vessel damage caused by the disease in
patients with poor glucose control"
Antioxidant vitamins may protect against female cancer - Nutra USA,
6/3/09 - "for every 1,000 microgram increase per
1,000 kcal of diet of beta-carotene was associated with a 12 per cent
reduction in the risk of endometrial cancer ... Similarly, for every 50
milligram increase per 1,000 kcal of vitamin C the risk of endometrial
cancer was reduced by 15 per cent, and for every 5 milligram increase per
1,000 kcal of vitamin E the risk of endometrial cancer was reduced by 9 per
cent" - [Abstract]
Vitamin C May Help Prevent Gout - WebMD, 3/9/09 -
"men who had the highest vitamin C intake from
supplements and food were up to 45% less likely to develop the painful
condition than those who had the lowest ... the results suggest that taking
vitamin C supplements at the levels in the study (less than 2,000 milligrams
per day) may be a safe and effective way to prevent gout"
Support For Adjunctive Vitamin C Treatment In Cancer - Science Daily,
3/5/09 - "Challem points out two main problems with
the study: the oxidized form of vitamin C (dehydroascorbic acid) and not
actual vitamin C (ascorbic acid) was used; and in the mouse experiments, the
animals were given toxic doses of dehydroascorbic acid, a compound that is
not used as a dietary supplement in humans ... This study and the subsequent
headlines [it generated] were a grievous disservice to physicians and
patients with cancer ... considerable positive research…has shown striking
benefits from high-dose vitamin C (ascorbic acid) in cancer cells and
animals—and in actual human beings"
Vitamin C Production: Molecular Gatekeeper In Enzyme Discovered -
Science Daily, 2/26/09
Vitamin C and BP - Medscape, 1/6/09 - "plasma
vitamin-C concentrations were inversely associated with blood pressure in
young women . The results suggest that this nutrient may favorably
influence blood pressure in healthy young adults ... plasma ascorbic acid at
year 10 was inversely associated with systolic and diastolic BP. Those in
the highest quartile of plasma vitamin C had 4.66-mm-Hg lower systolic BP
and 6.04-mm-Hg lower diastolic BP (p=0.0002) than those in the lowest
quartile ... Block says she has recently authored two papers detailing
possible mechanisms by which vitamin C could lower BP. These show that
vitamin C significantly lowers F2-isprostane, a marker of oxidative stress,
and CRP, a marker of inflammation [2,3]. "Both inflammation and oxidative
stress are pretty well established as having a role in hypertension ...
Vitamin C is a powerful antioxidant in vitro, and in some animal studies it
has been shown to act as a vasodilator, possibly by enhancing the
bioavailability of nitric oxide"
Vitamin C Lowers Levels Of Inflammation Biomarker Considered Predictor Of
Heart Disease - Science Daily, 11/14/08 - "for
people with elevated CRP levels, the amount of CRP reduction achieved by
taking vitamin C supplements in this study is comparable to that in many
other studies of cholesterol-lowering drugs called statins. They noted that
several larger statin trials lowered CRP levels by about 0.2 milligrams per
liter; in this latest study, vitamin C lowered CRP by 0.25 milligrams per
liter" - See
vitamin C products at Amazon.com.
Vitamin C, Chemotherapy: Bad Combo? - WebMD, 10/1/08 -
"What vitamin C does is protect the cancer cells
from the chemotherapy mainly by protecting their mitochondria [the cell's
Vitamin C May Prevent Hyperuricemia, Gout - Medscape, 9/26/08 -
"Hyperuricemia is considered a precursor of gout,
which is the most common inflammatory arthritis in adult men ... An
association was observed between greater vitamin C intake and lower
prevalence of hyperuricemia defined as > 6 mg/dL. The multivariable odds
ratio for hyperuricemia for the highest intake of vitamin C (>1000 mg/d)
compared to the lowest (<90 mg/d) was 0.34 ... These findings support a
potential role of vitamin C in the prevention of hyperuricemia and gout"
Vitamin C linked to Reduced Bone Loss in Older Men - WebMD, 9/19/08 -
"If you don't have enough vitamin C, you don't make
bones right. Collagen is the principal protein of bones, accounting for
nearly half the volume. What the collagen does is prevent bones from coming
Vitamin C Intake May Reduce Fracture Risk - Medscape, 9/15/08 -
"Basically, people who had higher levels of vitamin
C intake had half the rate of hip fractures as people who had the lowest
vitamin C [levels]"
C may help lower diabetes risk - MSNBC, 8/7/08 -
"the likelihood of developing diabetes was 62 percent lower in men and women
with the highest circulating vitamin C levels, relative to men and women
with the lowest vitamin C levels" - See
vitamin C products at Amazon.com.
Vitamin C Injections Slow Tumor Growth In Mice - Science Daily, 8/4/08 -
"high concentrations of ascorbate had anticancer
effects in 75 percent of cancer cell lines tested, while sparing normal
cells. In their paper, the researchers also showed that these high ascorbate
concentrations could be achieved in people" - Note: I was taking
about 8 grams of vitamin C per day
when I had neck cancer. Maybe that's what saved me.
Vitamin C-rich diet may slash diabetes risk - Nutra USA, 7/29/08 -
"Increased blood levels of vitamin C may reduce the
risk of developing diabetes by 62 per cent ... Correlating blood levels of
vitamin C and diabetes, the researchers found that men and women with the
highest blood levels (at least 1.10 and 1.29 mg/dL, respectively) had a 62
per cent reduction in their risk of developing type-2 diabetes, compared to
men and women with the lowest blood levels (less than 0.56 and 0.77 mg/dL,
Humans Make Up For An 'Inborn' Vitamin C Deficiency - Science Daily,
Vitamin C can keep you healthy, looking younger - CNN.com, 2/27/08 -
"people who ate foods rich in vitamin C had fewer
wrinkles and less age-related dry skin than those whose diets contained only
small amounts of the vitamin. C helps form collagen, which smooths fine
lines and wrinkles ... Farris recommends
La Roche-Posay Active C
facial moisturizer or
SkinCeuticals C E Ferulic
topical antioxidant treatment ... taking more than 700 milligrams of C
supplements daily reduced the risk of cardiovascular disease by 25 percent.
And a recent study from Harvard University researchers hints that women who
take a combo of 500 milligrams of vitamin C daily and 600 IU of vitamin E
(another antioxidant) can cut their risk of stroke by 30 percent ... Pairing
vitamins C and E is smart for another reason: It may lessen your Alzheimer's
risks by as much as 64 percent ..."
La Roche-Posay Active C
facial moisturizer or
SkinCeuticals C E Ferulic
at Amazon.com and vitamin C products at Amazon.com.
Fruit, Vegetable Eaters Have Fewer Strokes - WebMD, 1/9/08 -
"Specifically, vitamin C levels may prove to be a
good predictive indicator of stroke risk, independent of known risk factors
such as age, smoking history, blood pressure, and cholesterol, they write"
Vitamin C, Surgery, Arnica Montana - Dr. Weil, 1/4/08
Vitamin C linked to lower stroke risk: study - WebMD, 1/7/08 -
"The highest average blood levels of vitamin C
(greater than 66 micromoles per litre) were associated with a 42 per cent
lower risk of stroke, compared to the lowest average blood levels (less than
41 micromoles per litre)"
Vitamin C and dairy linked to less abdominal weight - Nutra USA,
11/16/07 - "low vitamin C
intake was associated with a 131 per cent increase in probability of
central fat accumulation, while low calcium
increased the probability by 30 per cent" - [Abstract]
Vitamin C May Slow Skin Wrinkling - WebMD, 10/8/07 -
"After adjusting for other factors likely to
influence skin aging, such as sun exposure and smoking, vitamin C and
linoleic acid were independently associated with skin aging ... After
digestion, linoleic acid is converted to DHA and EPA -- two fatty acids"
vitamin C products at Amazon.com
and Mega Twin EPA at Amazon.com. - Note: I'm not sure that is
correct. Linoleic acid is an omega-6, which is not converted to DHA and
EPA. Most Americans get about ten time too much omega-6 already.
Vitamin C Stops Cancer - Science Daily, 9/10/07 -
"Both of these cancers produce high levels of free radicals that can be
suppressed by feeding the mice supplements of antioxidants, either vitamin C
or N-acetylcysteine (NAC) ... Some rapidly growing tumors consume enough
energy to easily suck out the available oxygen in their vicinity, making
HIF-1 absolutely critical for their continued survival. But HIF-1 can only
operate if it has a supply of free radicals. Antioxidants remove these free
radicals and stop HIF-1, and the tumor, in its tracks"
Transforms Vitamin C From 'Good Cop' Into 'Bad Cop' - Science Daily,
9/4/07 - "Nitrites, which are present in human
saliva, and in certain preserved foodstuffs, may be converted to cancer
causing compounds called nitrosamines. Nitrosamines are formed in acidic
conditions, such as those afforded by stomach acid, but vitamin C inhibits
their formation, by converting nitrite to nitric oxide ... Without fat,
vitamin C curbed the levels of two nitrosamines by a factor of between five
and 1000. And it completely eliminated the production of the other two ...
But when 10% fat was added, vitamin C actually boosted the production of
nitrosamines between 8 and 140-fold"
- Is there anything
that I can do to aid recovery and reduce soreness [from exercise]?
- Dr. Murray - "Take 3,000-8,000 mg of vitamin C and
400-800 IU of
vitamin E in divided doses daily"
Vitamin C 'benefits diabetics' - BBC News, 6/28/07 -
"Vitamin C neutralises free radicals, while Telmisarten stimulates the
natural removal of the molecules by cells"
Vitamin C could lower body fat levels - Nutra USA, 4/6/06 -
"As vitamin C blood concentrations fell, so did the
participants' ability to oxidize fat (an 11 per cent reduction)"
Vitamin C could reduce inflammation - Nutra USA, 3/8/06 -
"High blood levels of vitamin C were associated with
a 45 per cent reduced risk of inflammation (with respect to CRP levels)"
Cortisol, Stress, and Health
- Life Extension Magazine, 12/05 -
"Supplements to reduce high
cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ...
Fish oil (omega-3
fatty acids):1-4 gm/day ... Phosphatidylserine:
300-800 mg/day ... Rhodiola rosea:
100-200 mg/day, standardized extract ... Ginseng:
100-300 mg/day, standardized extract ... Ginkgo
biloba: 100-200 mg/day, standardized extract ...
DHEA: 25-50 mg/day (any hormone supplementation should be monitored by
Study: Vitamin C May Fight Cancer - WebMD, 9/12/05 -
"Vitamin C appeared to boost production of hydrogen
peroxide, which killed cancer cells and left healthy cells unharmed ... The
levels of vitamin C were so high that they could only be achieved through IV
Discovery Shows New Vitamin C Health Benefits - Science Daily, 1/12/05 -
"the new discovery indicates it has a complex
protective role against toxic compounds formed from oxidized lipids,
preventing the genetic damage or inflammation they can cause"
Alternative Medicine: Vitamin C - The Epoch Times, 11/28/04 -
"Guinea pigs and primates are the only mammals known
that do not manufacture vitamin C in their gut. Other mammals not only
manufacture vitamin C (ascorbic acid), but do it on an as-needed basis. For
daily maintenance they manufacture what would be equivalent to a 150-pound
man taking 5 to 50 grams a day"
Study Shows Vitamins C And E Can Prevent Metabolic Damaage In Extreme
Exercise - Science Daily, 7/15/04 -
"ultramarathon runners who used supplements of
vitamins C and E for six weeks prior to their races totally prevented the
increase in lipid oxidation that is otherwise associated with extreme
- Vitamin C May
Fight Rheumatoid Arthritis - WebMD, 6/9/04 -
"people who ate the least amount of fruits and
vegetables had double the risk of developing inflammatory arthritis ...
People who got the least vitamin C in their diet had three times the risk of
developing inflammatory arthritis than those who got the most"
- Excess Vitamin
C May Worsen Osteoarthritis - WebMD, 6/3/04
Vitamin C supplement to beat diabetes and heart disease
- Nutra USA, 4/14/04 -
"Researchers at the University of California say
that participants who took about 500 milligrams of vitamin C supplements per
day saw a 24 per cent drop in plasma C-reactive protein (CRP) levels after
- Low Blood Levels of
Vitamin C Linked to Mortality - Medscape, 11/6/03 -
"Individuals in the lowest quintile for ascorbate concentration (<17 µmol/L)
had the highest mortality, whereas those in the highest quintile (>66
µmol/L) had the lowest mortality ... After excluding subjects with
cardiovascular disease or cancer at baseline, mortality for those in the
highest quintile was still about half of that in the lowest quintile"
The Chromium Connection - Natural Foods Merchandiser, 9/03 -
"The body requires certain nutrients to control
glucose metabolism, especially
chromium, zinc and
vitamins B and C"
Vitamin Supplements Improve Blood Vessel Function
- Physician's Weekly, 9/8/03 - "In a study where
were given doses of the antioxidants vitamins C and
E, researchers have found that the supplements can significantly improve
blood vessel function ... the test group received 500 mg of vitamin C and
400 IU of vitamin E daily. Both groups saw an 8% decline in LDL cholesterol
and the test group had significant improvement in endothelial function
comparable to the levels of normal healthy children"
E and C May Give Older Women a Mental Edge - Natural Foods Merchandiser,
8/03 - "The women who had taken vitamin C and
E supplements for more than 10 years scored an
average of 1.5 years younger in cognitive function
than those not taking vitamins. The results were even more marked for those
with low dietary vitamin E intake: Women with the lowest 30 percent of
dietary vitamin E intake who did not take supplements tested two years older
in mental function than women who compensated for low dietary intake with
Vitamin C May Protect Against Ulcer-Causing Bacteria
- Doctor's Guide, 8/1/03 -
"the lower the level of vitamin C in the blood the
more likely a person will become infected by Helicobacter pylori, the
bacteria that can cause
peptic ulcers and stomach cancer ...
The bottom line is that higher levels of vitamin C may have the potential to
prevent peptic ulcers and stomach cancer"
Vitamin C Reduces Oxidant Stress In Renal Failure
- Doctor's Guide, 3/26/03 -
"The acute administration of vitamin C reduces
oxidant stress in
renal failure, and improves nitric oxide-mediated resistance-vessel
dilatation ... In addition, vitamin C was found to increase the dilator
response to acetylcholine in resistance vessels"
- Vitamin C May
Fight Colds After All - WebMD, 3/12/03 - "12
healthy subjects who took one gram of vitamin C a day for two weeks showed a
boosted immune system response during that time ... in two of them, the
response to vitamin C took place within five hours ... this might mean that
taking a vitamin C tablet at the first sign of a cold
could achieve an effect quickly enough to ward off that cold"
- Vitamin C May Aid
People with Diabetes - New Hope Natural Media, 2/13/03 -
"randomly assigned to receive 500 mg of vitamin C per day or a placebo.
After four weeks of treatment, the average blood
decreased significantly in the group taking vitamin C, whereas no change was
seen in the placebo group. The systolic blood pressure (the higher number)
decreased by an average of 9.8 mm Hg, while the diastolic blood pressure
(the lower number) decreased by 4.4 mm Hg. These changes in blood pressure
are nearly as great as one might expect from taking a prescription blood
pressure-lowering medication. In addition, the stiffness of the arteries
decreased significantly in the vitamin C group ... Vitamin C inhibits all
three of the biochemical reactions that are believed to contribute to the
development of these complications: (1) the production of oxygen-derived
free radicals, (2) the accumulation of sorbitol within cells, and (3) a
tissue-damaging reaction called
- Vitamins C
and E may enhance effectiveness of insulin for diabetes
- University of California at Irvine, 1/29/03 -
insulin with vitamins C and
E may improve the drug's effectiveness for treating
diabetes ... the popular antioxidant supplements not only enhance
insulin's ability to reduce blood sugar, but also lower the risks of organ
damage that can occur despite insulin treatments"
- Vitamins C and E
Improve Outcome in Critically Ill Surgical Patients
- New Hope Natural Media, 1/9/03 - "The incidence of
multiple organ failure was significantly lower (by 57%) in the group
receiving antioxidants than in the control group (2.7% vs. 6.1%). In
addition, the average length of stay in the ICU was significantly lower (by
17%) in the antioxidant group. After 28 days, the mortality rate was 44%
lower in the antioxidant group than in the control group (1.3% vs. 2.4%),
but this difference was not statistically significant"
Vitamin C, Fish, And A Gout Drug Target Artery Damage From Smoking
- Intelihealth, 1/7/03 -
"vitamin C and
taurine, an amino acid in fish, reversed abnormal blood vessel response
associated with cigarette smoking - a discovery that may provide insight
into how smoking contributes to "hardening
of the arteries,""
- Antioxidant Vitamins
Improve Surgical Outcomes - Medscape, 12/20/02 -
"Compared with patients receiving standard care, those who received
antioxidant supplementation with
alpha-tocopherol and ascorbate had a shorter
duration of mechanical ventilation and length of ICU stay, and lower
relative risk (RR) of pulmonary morbidity (RR, 0.81; 95% confidence interval
[CI], 0.60 - 1.1) and of multiple organ failure (RR, 0.43; 95% CI, 0.19 -
Antioxidants May Reduce Alzheimer's Disease Risk - Clinical Psychiatry
News, 10/02 - "Use of
vitamins E and C together—which is what most subjects did—was associated
with an eightfold reduction in prevalence and a fivefold lower incidence of
Vitamins C And E Support Breathing Following An Operation
- Intelihealth, 9/12/02 -
"Patients who have recently undergone an operation
experience less breathing problems after being given a cocktail of vitamins
Vitamin C May Prevent Platelet Aggregation - Doctor's Guide, 5/28/02 -
"Vitamin C may inhibit collagen-induced platelet
aggregation. This may add to the protection that vitamin C is already known
to give against
coronary heart disease ... In smokers who received vitamin C, there were
significant decreases in platelet aggregation after six hours with both
collagen concentrations compared to placebo. In non-smokers, there were
significant decreases of platelet aggregation after three and six hours for
both collagen concentrations"
Vitamin C Beneficial In Heart Disease - Doctor's Guide, 5/27/02 -
"These two groups were split into subgroups: those
who received 2 g of vitamin C and those who did not after eating high-fat
meal ... Although the postprandial flow-mediated dilatation was
significantly aggravated in people not taking vitamin C (both with and
heart disease), this parameter in patients and subjects taking vitamin C
showed no significant change"
Proton Pump Inhibitor Therapy Reduces Bioavailability of Dietary Vitamin C
- Doctor's Guide, 5/20/02 - "The mean pre-treatment
plasma vitamin C concentration in
H. pylori -negative subjects was 25.1 mg/mL (range 16.1-33) and 17.4
mg/mL (6.7-29) in H. pylori-positive subjects (p<0.001). Mean daily dietary
intake of vitamin C was 44 mg/day (range 10-130) in H. pylori positive
subjects compared to 141 mg/day (range 23-282) negative subjects (p<0.001)
... Four week of omeprazole [Prilosec - the purple pill] treatment achieved
reductions in mean plasma vitamin C concentrations of 15 percent (p=0.005)
in H. pylori-positive and -negative subjects"
Vitamins Help After Heart Transplant - WebMD, 3/28/02 -
"The plaque-fighting benefits of the
antioxidant supplements were even greater than those found using statin
medications, which have already been shown to slow hardening of the arteries
after transplants. Previous research has shown that antioxidants, such as
vitamin C and E, can promote heart health by
reducing blood clots and keeping the blood vessels flexible"
Vitamins Effectively Prevent or Reverse Skin Damage
- Medscape, 3/02 - "Even minimal UV exposure can
decrease the vitamin C levels in the skin by 30%, while exposure from the
ozone of city pollution can decrease the level by 55%"
Vitamin C Reduces The Odds Of Developing Early-Onset Cataract
- Doctor's Guide, 2/22/02 - "A significant
interaction was observed between age, vitamin C intake, and the prevalence
of cataracts. For women younger than 60 years, the consumption of vitamin C
>/= 362 mg/day was associated with a 57 percent lower risk of developing
cortical opacities, and the use of vitamin C supplements for at least 10
years was associated with a 60 percent reduction in the risk of cataracts,
when compared to no supplement use ... the incidence of posterior
subcapsulary cataracts was considerably lower in women who had never smoked
and who had high intakes of folate and carotenoids"
- Vitamin C May
Improve Alzheimer's Treatments - WebMD, 1/14/02 -
"When ascorbic acid -- better known as vitamin C --
is chemically attached to certain drugs, it allows them to penetrate the
[blood brain] barrier, reaching more of its target cells within the brain
... they tested one of the modified drugs in mice with induced convulsions.
They injected some of the animals with the normal version of the drug and
others with the modified version. Only animals that received the drug with
attached vitamin C had delayed convulsions -- indicating that the drug was
Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's
Guide, 11/14/01 -
"increasing levels of serum
were associated with significant reductions in systolic
blood pressure, while increasing levels of serum vitamin C were
associated with significant reductions in diastolic pressure ... In
contrast, serum levels of vitamin E were
associated with significant increases in diastolic blood pressure"
Vitamin C Inhibits Cell Death In Congestive Heart Failure Patients
- Intelihealth, 10/30/01
Zinc, Antioxidants Prevent Some Forms of Vision Loss - WebMD, 10/12/01 -
"people at risk of losing more sight due to a
condition called "age-related macular degeneration" (AMD) could prevent
further vision loss by taking a combination of zinc and antioxidants,
including vitamins C and E and beta-carotene ... The antioxidants were taken
once a day at a dose of 500 mg of vitamin C, 400 IU of vitamin E, and 15 mg
of beta-carotene. Zinc was given as 80 mg of zinc oxide along with 2 mg of
copper in the form of cupric oxide to prevent anemia, which can occur from
too much zinc ... the high levels of dietary supplements that were taken in
this study are very difficult to achieve from diet alone"
Arterial Disease Depletes Body of Vitamin C - WebMD, 4/9/01 -
"In atherosclerosis, arteries and other blood
vessels are lined with fat deposits and buildup of cellular materials,
including inflammatory cells, which release unstable molecules called free
radicals. The free radicals do additional damage to the delicate vessels,
says Langlois. Antioxidants such as vitamin C seek out and destroy free
radicals, but in the process the antioxidants are themselves destroyed ...
PAD appears to kick the body's inflammatory process into high gear, which
then releases a free radical bombardment, that can "deplete the supply of
The Prediabetic Epidemic - Nutrition Science News, 3/01 -
"Supplements to Regulate Glucose and Insulin ...
Alpha-Lipoic Acid ...
Vitamin E ... Vitamin C ... Some research has found that 2,000 mg/day
vitamin C daily lowers both glucose and glycosylated hemoglobin levels, the
latter a standard marker of diabetic control ...
Vitamin C May Help Ward Off Osteoporosis - WebMD, 2/8/01 -
"Researchers have found that postmenopausal women
who took vitamin C supplements had a higher bone density than those who
didn't. The highest bone densities were also found in the women who were
taking more than 1,000 mg/d."
Vitamins and Vision, Lots of "C" May Help You See Later in Life - WebMD,
"Risk of cataracts was 60% lower among people who
took multivitamins or any supplement containing vitamin C or E for more than
Ulcer Therapy, Vitamins May Team Up to Prevent Stomach Cancer, Drugs Halted,
Healed Abnormalities With Cancer Potential - WebMD, 12/8/00 -
"people who took the three-drug combination alone or
in combination with vitamin C and/or beta carotene were three to five times
more likely than people who received no treatment to have a reduction in the
size of precancerous stomach abnormalities."
Paleolithic Nutrition: Your Future Is In Your Dietary Past - The
Nutrition Reporter - "This theory regarding how our
evolutionary ancestors lost their ability to produce vitamin C is generally
accepted by scientists, Stone's other theory is more controversial. He
contended that people never lost the need for large amounts of vitamin C,
even though they lost the ability to make it. Based on animal data, he
estimated that people might require 1.8-13 grams of vitamin C daily."
and vitamin C for the prevention of respiratory tract infections in children
attending preschool: a randomised controlled pilot study - Eur J Clin Nutr.
2014 Sep 10 - "children aged 3-6 years, 57 received 1.25
× 1010 colony-forming units of Lactobacillus acidophilus CUL21 (NCIMB 30156),
Lactobacillus acidophilus CUL60 (NCIMB 30157), Bifidobacterium bifidum CUL20
(NCIMB 30153) and Bifidobacterium animalis subsp. lactis CUL34 (NCIMB 30172)
plus 50 mg vitamin C or a placebo daily for 6 months.Results:Significant
reductions in the incidence rate of upper respiratory tract infection (URTI;
33%, P=0.002), the number of days with URTI symptoms (mean difference: -21.0,
95% confidence interval (CI):-35.9, -6.0, P=0.006) and the incidence rate of
absence from preschool (30%, P=0.007) were observed in the active group compared
with the placebo. The number of days of use of antibiotics, painkillers, cough
medicine or nasal sprays was lower in the active group and reached significance
for use of cough medicine (mean difference: -6.6, 95% CI: -12.9, -0.3, P=0.040)"
probiotic products at Amazon.com
vitamin C products at Amazon.com.
Acid Prevents High Glucose-induced Apoptosis in Human Brain Pericytes -
Biochem Biophys Res Commun. 2014 Aug 21 - "High glucose
concentrations due to diabetes increase apoptosis of vascular pericytes,
impairing vascular regulation and weakening vessels, especially in brain and
retina. We sought to determine whether vitamin C, or ascorbic acid, could
prevent such high glucose-induced increases in pericyte apoptosis ... the
prevention of apoptosis by ascorbate may involve effects beyond its function as
an antioxidant" - See
vitamin C products at Amazon.com.
supplementation slightly improves physical activity levels and reduces cold
incidence in men with marginal vitamin C status: a randomized controlled trial
- Nutrients. 2014 Jul 9;6(7):2572-83 - "The early
indications of vitamin C deficiency are unremarkable (fatigue, malaise,
depression) and may manifest as a reduced desire to be physically active;
moreover, hypovitaminosis C may be associated with increased cold duration and
severity ... This study examined the impact of vitamin C on physical activity
and respiratory tract infections during the peak of the cold season. Healthy
non-smoking adult men (18-35 years; BMI < 34 kg/m2; plasma vitamin C < 45
µmol/L) received either 1000 mg of vitamin C daily (n = 15) or placebo (n = 13)
in a randomized, double-blind, eight-week trial ... In the final two weeks of
the trial, the physical activity score rose modestly for the vitamin C group vs.
placebo after adjusting for baseline values: +39.6% (95% CI [-4.5,83.7]; p =
0.10). The number of participants reporting cold episodes was 7 and 11 for the
vitamin C and placebo groups respectively during the eight-week trial (RR =
0.55; 95% CI [0.33,0.94]; p = 0.04) and cold duration was reduced 59% in the
vitamin C versus placebo groups (-3.2 days; 95% CI [-7.0,0.6]; p = 0.06)"
acid- and L-ascorbic acid 2-glucoside accelerate in vivo liver regeneration and
lower serum alanine aminotransaminase activity in 70% partially hepatectomized
rats - Biol Pharm Bull. 2014;37(4):597-603 -
"L-Ascorbic acid and L-ascorbic acid 2-glucoside significantly lowered the serum
ALT on day 1 after PH compared with saline-, L-dehydroascorbic acid- and D-isoascorbic
acid-administered rats. These results demonstrate that L-ascorbic acid and
L-ascorbic acid 2-glucoside significantly promote the regeneration of liver mass
and function with full recovery after liver injury"
vitamin C on endothelial function in health and disease: A systematic review and
meta-analysis of randomised controlled trials - Atherosclerosis. 2014 Apr
18;235(1):9-20 - "endothelial function (EF) ... Pooling
the data from 44 clinical trials showed a significant positive effect of vitamin
C on EF (SMD: 0.50, 95% CI: 0.34, 0.66, P < 0.001). Stratification of the
analysis by health outcome revealed improved EF in atherosclerotic (SMD: 0.84,
95% CI: 0.41, 1.26, P < 0.001), diabetic (SMD: 0.52, 95% CI: 0.21, 0.82, P <
0.001) and heart failure patients (SMD: 0.48, 95% CI: 0.08, 0.88, P < 0.02)
after vitamin C supplementation ... The meta-regression showed a significant
positive association between vitamin C dose and improvement in EF"
Endothelial dysfunction - Wikipedia -
"endothelial dysfunction is a systemic pathological state of the endothelium
(the inner lining of blood vessels) and can be broadly defined as an
imbalance between vasodilating and vasoconstricting substances produced by
(or acting on) the endothelium ... Endothelial dysfunction can result from
and/or contribute to several disease processes, as occurs in hypertension,
hypercholesterolaemia, diabetes, septic shock, Behcet's disease, and it can
also result from environmental factors, such as from smoking tobacco
products and exposure to air pollution"
Ascorbic Acid and the Brain:
Rationale for the Use against Cognitive Decline - Nutrients. 2014 Apr
24;6(4):1752-81 - "This review highlights several key points relating to the
role of AA in healthy brain aging: (1) both human and animal studies demonstrate
AA deficiency in association with oxidative stress markers, and oxidative stress
is a consistent observation in AD; (2) there is inconsistency among the large
observational studies relating dietary intake of AA to cognition. However, it
remains unclear whether this inconsistency is methodological in nature (e.g.,
the subjective dietary surveys used to capture AA intake) since biomarkers of
both AA (and oxidative stress) present more consistent results favouring an
important role for AA in cognitive health; (3) there are genetic (SVCT1 and
SVCT2 SNPs) and non-genetic (e.g., age) factors that modulate AA absorption and
assimilation, which could indicate an increased demand for AA in subsets of the
population such as the elderly and those with an AD diagnosis. Thus, we do not
suggest that AA deficiency in isolation can explain AD neuro- and
psycho-pathology, however, we do propose more research focused on investigating
the specific role of AA in AD pathogenesis with meticulous attention to the
study design (e.g., people with low AA and high vascular risk may be best suited
Administrated Ascorbic Acid Suppresses Neuronal Damage and Modifies Expression
of SVCT2 and GLUT1 in the Brain of Diabetic Rats with Cerebral
Ischemia-Reperfusion - Nutrients. 2014 Apr 15;6(4):1554-77 -
"AA supplementation to the diabetic rats restored these
responses to the levels of the nondiabetic rats. Furthermore, AA markedly
upregulated the basal expression of GLUT1 in endothelial cells of nondiabetic
and diabetic cortex, which did not affect total AA levels in the cortex. These
results suggest that daily intake of AA attenuates the exacerbation of cerebral
ischemic injury in a diabetic state, which may be attributed to anti-apoptotic
and anti-inflammatory effects via the improvement of augmented oxidative stress
in the brain. AA supplementation may protect endothelial function against the
exacerbated ischemic oxidative injury in the diabetic state and improve AA
transport through SVCT2 in the cortex" - See
vitamin C products at Amazon.com.
Between Higher Plasma Lutein, Zeaxanthin, and Vitamin C Concentrations and
Longer Telomere Length: Results of the Austrian Stroke Prevention Study - J
Am Geriatr Soc. 2014 Jan 15 - "Individuals with a mean
age of 66 ± 7 (n = 786; 58% female) ... Concentrations of vitamin C, lutein,
zeaxanthin, β-cryptoxanthin, canthaxanthin, lycopene, α- and γ-tocopherol, α-
and β-carotene, and retinol in plasma, advanced oxidation protein products as a
measure of oxidative stress in serum, and LTL were measured ... Multiple linear
regression analyses with adjustment for age and sex demonstrated that higher
lutein, zeaxanthin, and vitamin C concentrations were strongly associated with
longer telomere length" - See
carotenoids at Amazon.com
vitamin C products at Amazon.com.
Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal
squamous cell carcinoma in a Chinese population - Am J Clin Nutr. 2013 Sep
11 - "China has some of the highest incidence rates for
gastric adenocarcinoma (GA) and esophageal squamous cell carcinoma (ESCC) in the
world ... Two cohort studies and the current study were included to assess the
body of evidence ... For GA, each 20-μmol/L increase in plasma vitamin C was
associated with a 14% decrease in risk ... Compared with individuals with low
plasma vitamin C concentrations (≤28 μmol/L), those with normal concentrations
(>28 μmol/L) had a 27% reduced risk of GA ... No association between vitamin C
concentrations and ESCC was seen"
Antioxidant Nutrients, Vitamin A, and Mortality in US Adults - Cancer
Epidemiol Biomarkers Prev. 2013 Jul 29 - "We evaluated
all-cause, cancer and cardiovascular mortality risks associated with quintiles
(Q1-Q5) of serum antioxidant (vitamins C and E, beta-carotene, and selenium) and
vitamin A levels, in 16,008 adult NHANES III (The Third National Health and
Nutrition Examination survey, 1988-1994) participants ... median follow-up
period of 14.2 years ... We observed a dose-response decrease in cancer and
overall mortality risks with higher vitamin C levels. In contrast, for vitamin
A, risk of cancer death decreased from Q1-Q2, with no further decline in risk at
higher levels. For vitamin E, having levels in Q4 were associated with the
lowest cancer mortality risk. Both vitamin A and E had U-shaped associations
with all-cause mortality. Cancer mortality risks decreased from Q1-Q2 for
beta-carotene and from Q1-Q4 for selenium. However, for beta-carotene and
selenium, overall mortality risks decreased from Q1-Q2 but then did not change
significantly with higher levels"
vitamin C and vitamin D administration on mood and distress in acutely
hospitalized patients - Am J Clin Nutr. 2013 Jul 24 -
"vitamin C (500 mg twice daily ... Vitamin C provided
for a mean of 8.2 d increased plasma vitamin C concentrations to normal (P <
0.0001) and was associated with a 71% reduction in mood disturbance (P = 0.0002)
and a 51% reduction in psychological distress"
of intake of antioxidant vitamins and fatty acids with asthma in pre-school
children - Public Health Nutr. 2012 Oct 1:1-6 -
"Compared with children with the lowest intake tertile for vitamin C and vitamin
E, those in the highest were significantly inversely associated with asthma;
adjusted OR (95 % CI) were 0.35 (0.14, 0.88) and 0.32 (0.12, 0.85),
respectively. A statistically significant trend was also observed. Fruit intake
showed an inverse but insignificant association with asthma. There were no
associations of any type of fatty acids with asthma" - See
vitamin C products at Amazon.com
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
and A1c Relationship in the National Health and Nutrition Examination Survey
(NHANES) 2003-2006 - J Am Coll Nutr. 2011 Dec;30(6):477-83 -
"The consumption of foods high in vitamin C has been associated with lower risk
of diabetes ... Vitamin C concentrations were inversely associated with A1c (p =
0.0202). Stronger inverse associations were observed in subjects 18-44 years of
age (p = 0.0017), as well as in female (p = 0.0035) and Mexican American (p =
0.0149) subgroups. Evidence of a significant interaction between vitamin C and
vitamin D was noted in subjects aged 18-44 years and in females (p = 0.0073 and
0.0095 respectively), with the inverse association tending to be evident at
lower levels of vitamin D"
vitamin C concentrations in patients on routine hemodialysis and its
relationship to patients morbidity and mortality Int J Vitam Nutr Res. 2011
Jul;81(4):197-203 - "hemodialysis (HD) patients ...
Forty-nine patients (53.8 %) had low levels of vitamin C concentration. There
was a significant relationship between vitamin C insufficiency and presence of
any co-morbidity in HD patients (p < 0.05). There was a significant difference
in vitamin C concentrations between patients without co-morbidities and those
with cardiovascular ones (F[2,88]=3.447, p = 0.036). Twenty-two (24.2 %)
patients died over a median duration of 227 days. There was a significant
difference in time to death of patients with and without low levels of vitamin C
concentration (p = 0.04). Conclusions: The results showed lower plasma vitamin C
levels in HD patients who suffered any co-morbidity and sooner time to death in
mineral supplement intake and the risk of head and neck cancer: Pooled analysis
in the INHANCE consortium - Int J Cancer. 2011 Dec 15 -
"To investigate the potential role of vitamin or mineral
supplementation on the risk of head and neck cancer (HNC), we analyzed
individual-level pooled data from 12 case-control studies ... A decreased risk
of HNC was observed with ever use of vitamin C (OR=0.76, 95% CI=0.59-0.96) and
with ever use of calcium supplement (OR=0.64, 95% CI=0.42-0.97). The inverse
association with HNC risk was also observed for 10 or more years of vitamin C
use (OR=0.72, 95% CI=0.54-0.97) and more than 365 tablets of cumulative calcium
intake (OR=0.36, 95% CI=0.16-0.83), but linear trends were not observed for the
frequency or duration of any supplement intake. We did not observe any strong
associations between vitamin or mineral supplement intake and the risk of head
and neck cancer"
Effect of Vitamin C in Combination With Vitamin K3 on Tumor Growth and
Metastasis of Lewis Lung Carcinoma Xenografted in C57BL/6 Mice - Nutr
Cancer. 2011 Sep 2 - "Vit CK3 restored the body weight
of tumor-bearing mice to the level of tumor-free mice ... These results
demonstrate that vit CK3 inhibits primary tumor growth and exhibits
antimetastastic potential in vivo through attenuated tumor invasion and
proliferation" - See
vitamin C products at Amazon.com
vitamin K at Amazon.com.
Intakes of Antioxidant Vitamins and Mortality From Cardiovascular Disease: The
Japan Collaborative Cohort Study (JACC) Study - Stroke. 2011 Apr 21 -
"investigated the relation of dietary vitamins A, E, and
C intake with mortality from cardiovascular disease for Japanese men and women
... The multivariable hazard ratios (95% CI) associated with the highest versus
lowest quintiles of vitamin C intake were 0.70 (0.54 to 0.92) for total stroke,
0.63 (0.41 to 0.97) for coronary heart disease, and 0.79 (0.66 to 0.94) for
total cardiovascular disease for women, but the inverse associations observed
were weak and did not reach statistical significance for men. No significant
association was observed between vitamins A or E intake and risk of mortality
for either men or women"
vitamins C and E on antioxidant status of breast-cancer patients undergoing
chemotherapy - J Clin Pharm Ther. 2011 Jan 4 - "VCE
(vitamin C 500 mg tablet and vitamin E 400 mg gelatin capsule ... The untreated
group showed significantly lower levels of antioxidant enzymes (P<0.001) and
reduced glutathione (P<0.001), and more extensive lipid peroxidation (P<0.001)
and DNA damage than healthy controls. Similar but less pronounced patterns were
observed in the patients receiving chemotherapy alone. The group of patients
receiving VCE supplementation had all the marker levels moving towards normal
values. Activities of superoxide dismutase, catalase, glutathione-S-transferase
and glutathione reductase, and the levels of reduced glutathione were
significantly increased (P<0.01) while, the levels of malondialdehyde and DNA
damage were significantly (P<0.01) reduced in the VCE supplemented group
relative to those of patients receiving chemotherapy alone as well as relative
to the pretreatment levels"
effects of ascorbic acid and thiazolidinedione on secretion of high molecular
weight adiponectin from human adipocytes - Diabetes Obes Metab. 2010
Dec;12(12):1084-9 - "AA supplementation significantly
increased secretion of HMW
adiponectin (1.7-fold) without altering
adiponectin expression or total adiponectin secretion. TZD significantly
increased expression (3-fold) and secretion of total (1.4-fold) but not HMW
adiponectin. Combined supplementation resulted in a significant increase in
expression (3-fold) and secretion of total (1.8-fold) and HMW (5-fold)
adiponectin. Similar results were seen in cells co-treated with TNFα" -
See my adiponectin page. High adiponectin is a
good thing. Actos
(pioglitazone) is a TZD and is something I've been taking for anti-aging for
some time. Not only does it increase adiponectin but it increases insulin
sensitivity. See my
Insulin and Aging page. See pioglitazone at
High-dose Vitamin C on Oxygen Free Radical Production and Myocardial Enzyme
after Tourniquet Ischaemia-Reperfusion Injury during Bilateral Total Knee
Replacement - J Int Med Res. 2010 Jul-Aug;38(4):1519-29 -
"In the VC group, malondialdehyde levels were lower, and
arterial oxygen tension and mean blood pressure were higher, than in controls
after post-operative deflation of both knee tourniquets. Troponin I levels were
lower in the VC group than in controls 8 h post-operation. Administering
high-dose vitamin C during bilateral TKR could prevent oxygen free radical
production and a decline in arterial oxygen tension and mean blood pressure
induced by ischaemia-reperfusion injury, thereby protecting the myocardium"
Intake of fatty acids and
antioxidants and pancreatic cancer in a large population-based case-control
study in the San Francisco Bay Area - Int J Cancer. 2010 Oct
15;127(8):1893-904 - "Positive associations were
observed for high levels of the 8 individual saturated fatty acids (4th vs. 1st
quartile: ORs ranged from 1.6 to 2.6; all p(trend) < 0.01), monounsaturated
palmitoleic and oleic fatty acids [OR = 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI:
1.1-1.9); both p(trend) < 0.01], and polyunsaturated linolenic acid [OR = 1.5
(95% CI: 1.1-2.0); p(trend) = 0.02]. Inverse associations were observed for high
levels of gadolic acid [4th vs. 1st quartile: OR = 0.68 (95% CI: 0.50-0.92);
p(trend) = 0.007] and omega-3 fatty acids [>or=0.85 g/day vs. 1st quartile: OR =
0.47 (95% CI: 0.25-0.90)]. An inverse association was also observed for high
total intake of vitamin C [4th vs. 1st quartile: OR = 0.69 (95% CI: 0.51-0.94);
p(trend) = 0.004] and of vitamin E [OR = 0.67 (95% CI: 0.49-0.92); p(trend) =
effects of vitamin C supplementation on incident and progressive knee
osteoarthritis: a longitudinal study - Public Health Nutr. 2010 Aug
16:1-7 - "In the present prospective cohort study,
we found no evidence to support a protective role of vitamin C in the
progression of knee OA. However, after controlling for confounding
variables, these data suggest that vitamin C supplementation may indeed be
beneficial in preventing incident knee OA. Given the massive public health
burden of OA, the use of a simple, widely available and inexpensive
supplement to potentially reduce the impact of this disease merits further
C requirement in surgical patients - Curr Opin Clin Nutr Metab Care.
2010 Aug 4 - "Blood vitamin C concentration falls
after uncomplicated surgery and further decreases in surgical intensive care
unit patients. The decline may be owing to increased demand caused by
increased oxidative stress. To normalize plasma vitamin C concentration,
much higher doses than the recommended daily allowance or doses recommended
in parenteral nutrition guidelines are needed in these patients. In
uncomplicated surgical patients, more than 500 mg/day of vitamin C may be
required, with much higher doses in surgical intensive care unit patients.
In uncomplicated gastrointestinal surgery, continuous parenteral
administration of 500 mg/day of vitamin C reduced postoperative oxidative
stress as manifested by reduced urinary excretion of isoprostane. In some
studies, postoperative atrial fibrillation was prevented after cardiac
surgery by perioperative vitamin C supplementation. In critically ill
patients, some prospective randomized controlled trials support parenteral
supplementation of high doses of vitamin C, E and trace elements"
dose of ascorbic acid induces cell death in mesothelioma cells - Biochem
Biophys Res Commun. 2010 Feb 18 - "High dose of
ascorbic acid induced cell death of all mesothelioma cell lines in a
dose-dependent manner ... These data suggest that ascorbic acid may have
benefits for patients with mesothelioma"
Acid for Anemia Management in Hemodialysis Patients: A Systematic Review and
Meta-analysis - Am J Kidney Dis. 2009 Sep 22 -
"Combining the 3 randomized clinical trials involving patients with baseline
hemoglobin levels <11 g/dL, change in hemoglobin level was greater for
ascorbic acid use compared with standard care (WMD, 0.9 g/dL; 95% CI,
0.5-1.2 g/dL). Compared with standard care, ascorbic acid use also was
associated with a statistically significant decrease in rHuEPO dose (WMD,
-17.1 U/kg/wk; 95% CI, -26.0 to -8.2 U/kg/wk) and improvement in transferrin
saturation (WMD, 7.9%; 95% CI, 5.2-10.5%), with no change in ferritin
vitamin C concentration and hs-CRP level in middle-aged Japanese men and
women - Atherosclerosis. 2009 Aug 7 - "Inverse
associations between serum vitamin C concentrations and hs-CRP levels were
established for both men and women. Multivariable-adjusted mean values of
hs-CRP for the lowest to highest quintiles of vitamin C levels were 0.75,
0.65, 0.61, 0.61 and 0.47mg/L (P for trend <0.001) for men, and 0.56, 0.51,
0.49, 0.41 and 0.41mg/L (P for trend <0.001) for women. The inverse
association between vitamin C and hs-CRP was stronger for non-smoking men
and women, non-overweight women and postmenopausal women ... Serum vitamin C
concentrations were found to be inversely associated with hs-CRP levels in
both men and women, primarily among non-smokers, non-overweight women and
Vitamin C deficiency in early postnatal life impairs spatial memory and
reduces the number of hippocampal neurons in guinea pigs - Am J Clin
Nutr. 2009 Jul 29 - "Our data show that vitamin C
deficiency in early postnatal life results in impaired neuronal development
and a functional decrease in spatial memory in guinea pigs. We speculate
that this unrecognized effect of vitamin C deficiency may have clinical
implications for high-risk individuals, such as in children born from
vitamin C-deficient mothers"
Antioxidant vitamins and the risk of endometrial cancer: a dose-response
meta-analysis - Cancer Causes Control. 2009 Jul;20(5):699-711 -
"Based on case-control data, the random-effects
summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98)
per 1,000 mcg/1,000 kcal (I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI:
0.73-0.98) per 50 mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E:
0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
Multivitamin use and telomere length in women - Am J Clin Nutr. 2009
Jun;89(6):1857-63 - "After age and other potential
confounders were adjusted for, multivitamin use was associated with longer
telomeres. Compared with nonusers, the relative telomere length of leukocyte
DNA was on average 5.1% longer among daily multivitamin users (P for trend =
0.002). In the analysis of micronutrients, higher intakes of vitamins C and
E from foods were each associated with longer telomeres, even after
adjustment for multivitamin use. Furthermore, intakes of both nutrients were
associated with telomere length among women who did not take multivitamins"
of plant foods and associated nutrients in prostate cancer risk - Nutr
Cancer. 2009;61(2):216-24 - "Plant foods and
associated nutrients may impact prostate cancer (PC) risk and survival ...
Reduced PC risk was associated with the highest tertile of cryptoxanthin (OR
= 0.51; 95% CI = 0.35-0.75), fiber (OR = 0.56; 95% CI = 0.35-0.89), vitamin
C (OR = 0.60; 95% CI = 0.41-0.88), and fruits and/or fruit juices (OR =
0.46; 95% CI = 0.31-0.68), with significant linear trends. Increased risk of
PC was associated with the highest tertile of protein (OR = 1.99; 95% CI =
1.05-3.79) and daily servings of grains (OR = 1.99; 95% CI = 1.23-3.22) with
significant linear trends"
Vitamin C-rich foods may boost artery health - Nutra USA, 2/17/09 -
"increased intakes of vitamin C and fruit and
berries were associated with less thickening of the carotid artery ... one
mg per decilitre increase in blood vitamin C levels was linked to a 4.1 and
4.0 mmHg in systolic and diastolic blood pressures" - [Abstract]
Vitamin C consumption
is associated with less progression in carotid intima media thickness in
elderly men: A 3-year intervention study - Nutr Metab Cardiovasc Dis.
2009 Jan;19(1):8-14 - "Vitamin C containing foods
may protect against the progression of carotid atherosclerosis in elderly
C: Is Supplementation Necessary for Optimal Health? - J Altern
Complement Med. 2008 Nov 25 - "Consumption of
vitamin C is essential for life in humans because the body does not
synthesize it. Numerous studies have demonstrated that supplementation with
vitamin C enhances the immune system, avoids DNA damage, and significantly
decreases the risk of a wide range of pathologies, such as cancers, and
degenerative and chronic diseases. Moreover, it has been demonstrated that
modern crop production, transport, and food storage severely impair the
quality of food and provoke a loss in micronutrients, such as vitamin C ...
In this paper, we report that the Recommended Daily Allowance (RDA) in
vitamin C is lower than the bodily needs. In fact, it does not seem to
ensure true health protection and it appears difficult to reach an effective
dose of vitamin C only through food consumption. Furthermore, the literature
shows that vitamin C intake higher than the RDA is safe. Therefore, in order
to achieve optimal health and avoid a number of diseases, we suggest that,
in the present situation, vitamin C supplementation is required ...
According to the current literature, we would like to emphasize that to
ensure an optimal allowance of vitamin C, we advise 1 g daily intake of
vitamin C supplementation, accompanied by a diet rich in fruits and
C-lipid metabolites: Uptake and retention and effect on plasma C-reactive
protein and oxidized LDL levels in healthy volunteers - Med Sci Monit.
2008 Nov;14(11):CR547-551 - "ascorbic acid (AA),
calcium ascorbate (CaA) ... PureWay-C(R) supplementation leads to the
highest absolute serum vitamin C levels when compared to AA, CaA and
Ester-C(R). PureWay-C(R) provides a statistically significant greater serum
level than calcium ascorbate at 1, 2, 4, and 6 hours post oral
supplementation whereas Ester-C(R) shows a less but slightly statistically
significant increase at only 1 and 4 hours. Oral supplementation with
PureWay-C(R) also led to a greater reduction in plasma C-reactive protein
and oxidized LDL levels compared to the other vitamin C formulations.
Conclusions: PureWay-C(R) is more rapidly absorbed and leads to higher serum
vitamin C levels and greater reduction of plasma levels of inflammatory and
oxidative stress markers than other forms of vitamin C, including
Ester-C(R)" - See
vitamin C products at Amazon.com.
Vitamin C consumption is associated with less progression in carotid intima
media thickness in elderly men: A 3-year intervention study - Nutr Metab
Cardiovasc Dis. 2008 May 7 - "Vitamin C containing
foods may protect against the progression of carotid atherosclerosis in
Vitamin C Intake and Serum Uric Acid Concentration in Men - J Rheumatol.
2008 May 1 - "An inverse dose-response association
was observed through vitamin C intake of 400-500 mg/day, and then reached a
plateau ... Greater vitamin C intake was associated with lower prevalence of
hyperuricemia (serum uric acid > 6 mg/dl). Multivariate odds ratios for
hyperuricemia across total vitamin C intake categories were 1 (reference),
0.58, 0.57, 0.38, and 0.34 (95% CI 0.20-0.58; P for trend < 0.001). When we
used dietary data, which were assessed 4-8 years before blood collection, as
predictors, we observed similar inverse associations between vitamin C
intake and uric acid ... These population-based data indicate that vitamin C
intake in men is inversely associated with serum uric acid concentrations.
These findings support a potential role of vitamin C in the prevention of
hyperuricemia and gout"
12 week, open label, phase I/IIa study using apatone for the treatment of
prostate cancer patients who have failed standard therapy - Int J Med
Sci. 2008 Mar 24;5(2):62-7 - "oral Apatone (Vitamin
C and Vitamin K3) administration in the treatment of prostate cancer ...
5,000 mg of VC and 50 mg of VK3 each day ... At the conclusion of the 12
week treatment period, PSAV decreased and PSADT increased in 13 of 17
patients (p < or = 0.05). There were no dose-limiting adverse effects. Of
the 15 patients who continued on Apatone after 12 weeks, only 1 death
occurred after 14 months of treatment"
Dehydroascorbic acid as an anti-cancer agent - Cancer Lett. 2008 Mar 28
- "dehydroascorbic acid has the remarkable ability
to eliminate the aggressive mouse tumours, L1210, P388, Krebs sarcoma, and
Dehydroascorbic acid - Wikipedia -
"Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid"
Plasma vitamin C concentrations predict risk of incident stroke over 10 y in
20 649 participants of the European Prospective Investigation into Cancer
Norfolk prospective population study - Am J Clin Nutr. 2008
Jan;87(1):64-9 - "persons in the top quartiles of
baseline plasma vitamin C concentrations had a 42% lower risk (relative
risk: 0.58; 95% CI: 0.43, 0.78) than did those in the bottom quartile"
Oral administration of vitamin C decreases muscle mitochondrial biogenesis
and hampers training-induced adaptations in endurance performance - Am J
Clin Nutr. 2008 Jan;87(1):142-9 - "The
administration of vitamin C significantly (P = 0.014) hampered endurance
Ascorbic Acid Decreases the Binding Affinity of the AT(1) Receptor for
Angiotensin II - Am J Hypertens. 2008 Jan;21(1):67-71 -
"Ascorbic acid decreases the binding affinity of the
AT(1) receptor. These results offer a mechanistic explanation for the
reported blood pressure lowering effect of ascorbic acid"
Dietary and non-dietary determinants of central adiposity among Tehrani
women - Public Health Nutr. 2007 Sep 3;:1-7 -
"Marriage (1.31; 1.10-1.82), menopause (1.22; 1.02-1.61), low vitamin C
intake (2.31; 1.25-4.25) and low calcium intake (1.30; 1.07-3.78) were
associated with central fat accumulation"
Dietary nutrient intakes and skin-aging appearance among middle-aged
American women - Am J Clin Nutr. 2007 Oct;86(4):1225-1231 -
"Higher intakes of vitamin C and linoleic acid and
lower intakes of fats and carbohydrates are associated with better
skin-aging appearance. Promoting healthy dietary behaviors may have
additional benefit for skin appearance in addition to other health outcomes
in the population"
Supplementation with vitamins C and e improves arterial stiffness and
endothelial function in essential hypertensive patients - Am J
Hypertens. 2007 Apr;20(4):392-7 -
"Combined treatment with vitamins C and E has
beneficial effects on endothelium-dependent vasodilation and arterial
stiffness in untreated, essential hypertensive patients"
Intravenously administered vitamin C as cancer therapy: three cases -
CMAJ. 2006 Mar 28;174(7):937-942 -
"We found 3 well-documented cases of advanced
cancers, confirmed by histopathologic review, where patients had
unexpectedly long survival times after receiving high-dose intravenous
vitamin C therapy"
Associations of vitamin C status, fruit and vegetable intakes, and markers
of inflammation and hemostasis
- Am J Clin Nutr. 2006 Mar;83(3):567-574 - "The
findings suggest that vitamin C has antiinflammatory effects and is
associated with lower endothelial dysfunction in men with no history of
cardiovascular disease or diabetes"
Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical
Conditions - Annals of Nutrition and Metabolism 2006;50:85-94 -
"These trials document that adequate intakes of
vitamin C and zinc ameliorate symptoms and shorten the duration of
respiratory tract infections including the common cold"
Effects of vitamin C on intracoronary L-arginine dependent coronary
vasodilatation in patients with stable angina - Heart. 2005
Oct;91(10):1319-23 - "L-arginine dependent coronary
segment vasodilatation was augmented by the antioxidant vitamin C in
patients with coronary artery disease. Thus, vitamin C may have beneficial
effects on nitric oxide bioavailability induced by L-arginine"
Vitamins E and C are safe across a broad range of intakes - Am J Clin
Nutr. 2005 Apr;81(4):736-45 -
"vitamin E supplements appear safe for most adults
in amounts </=1600 IU (1073 mg RRR-alpha-tocopherol or the molar equivalent
of its esters) and that vitamin C supplements of </=2000 mg/d are safe for
Antioxidant vitamins and mortality in older persons
- Am J Clin Nutr. 2003 Nov;78(5):999-1010 -
"We found strong inverse trends for blood ascorbate
concentrations with all-cause and cardiovascular disease mortality ... Low
blood vitamin C concentrations in the older British population are strongly
predictive of mortality"
Vitamin C Inhibits Lipid Oxidation in Human HDL - J Nutr. 2003
Oct;133(10):3047-51 - "In the absence of vitamin C,
lipid oxidation in HDL began immediately and proceeded rapidly ... Vitamin C
(50-200 micro mol/L) retarded initiation of lipid oxidation for at least 4 h
under the same conditions ... Our results demonstrate that vitamin C
inhibits lipid oxidation in HDL and preserves the antioxidant activity
associated with this lipoprotein fraction"
Antioxidant vitamins C and E improve endothelial function in children with
hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY)
Trial - Circulation. 2003 Sep 2;108(9):1059-63. Epub 2003 Aug 11
Oral Antioxidant Therapy Improves Endothelial Function in Type 1 but not
Type 2 Diabetes Mellitus - Am J Physiol Heart Circ Physiol. 2003
"subjects were randomized to oral vitamin C 1000 mg
and vitamin E 800 IU daily or matching placebo for six months ... Oral
antioxidant therapy improves EDV in T1 but not T2 diabetes" - The
measurement of Vitamin E in IUs shows that they are still using
d-alpha-tocopherol or worse, the dl-alpha-tocopherol instead of mixed
tocopherols including the tocotrienols in studies. Just for starters, the
d-alpha lowers gamma.
Effect of Ascorbic Acid Consumption On Urinary Stone Risk Factors
- J Urol. 2003 Aug;170(2):397-401
Influence of Vitamin C on Baroreflex Sensitivity in Chronic Heart Failure
- Hypertension 2003 May 12 -
"Chronic heart failure (CHF) reduces baroreflex
sensitivity. Low baroreflex sensitivity, a risk factor for sudden death,
could arise partly from CHF-dependent endothelial dysfunction. Vitamin C at
high doses has a protective role against CHF-related endothelial damage ...
In subjects with CHF, baroreflex sensitivity was significantly higher after
vitamin C than after placebo infusion ... Acute administration of vitamin C
at high doses improves baroreflex sensitivity and vagal sinus modulation in
patients with CHF"
Plasma vitamin C, cholesterol and homocysteine are associated with grey
matter volume determined by MRI in non-demented old people - Neurosci
Lett 2003 May 8;341(3):173-6 - "We found that lower
grey matter volume was associated with lower plasma vitamin C and higher
and LDL. Lower blood cell folate was also
associated with lower grey matter volume ... These data are consistent with
the putative benefits of dietary vitamin C and folate intake and the role of
cholesterol in age related neurodegeneration"
High-dose antioxidant supplements and cognitive function in
community-dwelling elderly women - Am. J. of Clin. Nutr., 4/03 -
"Long-term, current users of
vitamin E with vitamin C had significantly better mean performance, as
judged by a global score that combined individual test scores, than did
women who had never used vitamin E or C (P = 0.03); there was a trend for
increasingly higher mean scores with increasing durations of use (P = 0.04).
These associations were strongest among women with low dietary intakes of
alpha-tocopherol. Benefits were less consistent for women taking vitamin E
alone, with no evidence of higher scores with longer durations of use. Use
of specific vitamin C supplements alone had little relation to performance
on our cognitive tests"
No contribution of ascorbic acid to renal calcium oxalate stones - Ann
Nutr Metab 1997;41(5):269-82
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