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Home > Anti-aging Research > Policosanol
Policosanol/Octacosanol
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Recommendations:
News & Research:
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Study Indicates Widely-Used Nutritional Supplement Does Not Improve
Cholesterol Levels - Doctor's Guide, 5/17/06
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'Bad' Cholesterol:
Supplement No Help? - WebMD, 5/16/06
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Effects of Rice Policosanol in Hypercholesterolaemic Patients -
Medscape, 11/29/05
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Meta-Analysis of Natural Therapies for Hyperlipidemia - Medscape,
3/18/05 - "Because policosanol seems
to be an efficient inhibitor of platelet aggregation -- policosanol 20
mg/day is equivalent to aspirin 100 mg/day -- caution may be indicated with
concomitant use of anticoagulants or antiplatelet agents ... policosanol is
a valuable addition to the usual therapeutic lifestyle changes and may be an
attractive alternative to conventional lipid-lowering drugs"
- Policosonal: Nature's Cholesterol Balancer - Vitamin Research News, 2/04 - "Statin drugs are also known to cause male impotence"
- Cholesterol-Lowering Supplements (Guggulsterones, Policosanol, Sterols) review - ConsumerLab.com, 8/1/03 -
"Policosanol ... Significantly lowers total
cholesterol and LDL. Increases HDL"
- Controlling Cholesterol Naturally - Natural Foods Merchandiser, 8/03
- Policosanol more Effective than Lovastatin for Intermittent Claudication - New Hope Natural Media, 5/29/03 -
"Those taking policosanol had a 34% increase in pain-free walking
distance, while no change was observed in those taking lovastatin. Quality of life was also reported as being significantly better in the policosanol group compared with the lovastatin group. Both treatment groups had significant reductions in total cholesterol and LDL cholesterol.
However, participants taking policosanol had a significant 32% increase in HDL cholesterol and a 6% decrease in fibrinogen, while these parameters remained unchanged in those receiving lovastatin" - Claudication gets my attention because my father has
it and if there is a hereditary factor, I want to prevent it. - Ben
- Similar Effect on Platelet Aggregation Seen With Policosanol at 20 and 40 Mg - Doctor's Guide, 9/11/02 -
"After 30 days, policosanol reduced
low-density lipoprotein-cholesterol by 15.9 and 17.0 percent at 20 and 40 mg daily respectively. Total cholesterol declined by 12.4 and 12.3 per cent, respectively. High-density lipoprotein-cholesterol rose by 5 per cent in both groups"
- Policosanol Helps Reduce High Cholesterol - New Hope Natural Media, 6/6/02 -
"In a six-month study, 10 mg per day of policosanol reduced total cholesterol by 16% and LDL
cholesterol by 24%, and increased HDL cholesterol by 29%. Several other studies have compared policosanol with some of the conventional medications used for lowering cholesterol and the results have shown policosanol in the amount of 5 to 20 mg per day to be
more effective than lovastatin (Mevacor®), pravastatin (Pravachol®),
and simvastatin (Zocor®), with fewer reported side effects. While some prescription drugs used to lower cholesterol may cause liver and muscle problems in rare instances, people taking policosanol have not suffered any
serious side effects"
- Octacosanol Beats Statins - Dr. Janson, 4/02 -
"In a study of octacosanol and Pravachol
(pravastatin), 10 mg daily of either product lowered LDL- cholesterol by 19.3 percent, the drug only 15.6 percent, it lowered total cholesterol by 13.9 percent (the drug only 11.8)."
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New
Human Studies Confirm Cholesterol-Lowering Effects of Policosanol - Life Extension Magazine, 2/02
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What
is the difference between policosanol and octacosanol? - Life Extension Magazine, 1/02
- Cuban Lipid Crisis - Nutrition Science News, 11/01 -
"Policosanol is similar in function and potency to some statin drugs ... After using 10 mg/day policosanol for two years, study participants tripled their treadmill walking distance. The placebo group experienced insignificant change"
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A
Natural Anti-Cholesterol Dietary Supplement, Policosanol - Life Extension Magazine, 6/01 -
"policosanol lowered LDL cholesterol 20% in 6 to 12 weeks at 10 mg/day. Total cholesterol was reduced 15%, and HDL increased 7%-28%. Taking 20 mg/day reduced LDL about 28%, total
cholesterol about 20%, and elevated HDL 7%-10%"
Abstracts:
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Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol)
in elderly hypercholesterolemic patients - Adv Ther. 2011 Nov 21 -
"containing berberine 500 mg, policosanol 10 mg, red
yeast rice 200 mg, folic acid 0.2 mg, coenzyme Q10 2.0 mg, and astaxanthin
0.5 mg) or placebo ... There was a statistically significant reduction in
total cholesterolemia (-20%), LDL-C (-31%), and insulin resistance (-10%)
with nutraceutical treatment. No significant changes were detected for
plasma high-density lipoprotein cholesterol (HDL-C). Furthermore, no
statistical differences were found between baseline and end-study safety
parameters. Medication compliance and tolerability were high" - Note:
I’m been promoting synergy and talking lower doses of everything proven in
specific areas like this for some time.
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Effect
of omega-3 and policosanol supplementation on attention and reactivity in
athletes - J Am Coll Nutr. 2009 Aug;28 - "After
21 days of supplementation, subjects who received O3 + P showed a reduced
reaction time and increased vigor sensation associated with a reduction of
the negative states measured with the POMS test. Analysis of the
event-related brain potentials showed a reduced latency of the
movement-related brain macropotentials. In particular, the potentials
recorded in the premotor period and motor period occurred earlier and the
latency of EMG activation was reduced. In the third test, 21 days after the
last O3 + P supplementation, the positive effects on the mood state
persisted, while the reaction time, EMG, and brain potential latencies
increased, although their values remained lower than in the first test. The
placebo group did not show any significant differences in Tests 2 and 3
compared to Test 1 for either POMS or reactivity and brain potentials"
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Policosanol is ineffective in the treatment of hypercholesterolemia: a
randomized controlled trial - Am J Clin Nutr. 2006 Dec;84(6):1543-8 -
"Policosanol does not alter the
serum lipid profile over an 8-wk period in adults with mild
hypercholesterolemia"
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Lack of cholesterol-lowering efficacy of Cuban sugar cane policosanols in
hypercholesterolemic persons - Am J Clin Nutr. 2006 Nov;84(5):1003-8 -
"2-40 mg Cuban sugar cane
policosanol (SCP) mixtures/d ... Present results show no beneficial effects
of Cuban SCPs on lipid indicators in hypercholesterolemic persons and
question the clinical usefulness of policosanol mixtures as
cholesterol-lowering neutraceutical agents"
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Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations - Metabolism.
2004 Oct;53(10):1309-1314
- Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent - Am Heart J 2002 Feb;143(2):356-65 -
"At doses of 10 to 20 mg per day, policosanol lowers total cholesterol by 17% to 21% and low-density lipoprotein (LDL) cholesterol by 21% to 29% and raises high-density lipoprotein cholesterol by 8% to 15%"
- Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study - Int J
Clin Pharmacol Res 2001;21(1):43-57 - "although the tolerability profile remains excellent, according to the present results policosanol at a dose of 40 mg/day does not offer significant additional cholesterol-lowering efficacy over the 20 mg/day dose"
- Effects of policosanol in older patients with type II hypercholesterolemia and high coronary risk - J Gerontol A Biol Sci Med Sci 2001 Mar;56(3):M186-92 -
"After 6 weeks on a lipid-lowering diet, 179 patients randomly received a placebo or policosanol at doses of 5 followed by 10 mg per day for successive 12-week periods of each dose. Policosanol (5 and 10 mg/d) significantly (p < .001) reduced low-density lipoprotein
cholesterol (LDL-C; 16.9% and 24.4%, respectively) and total cholesterol (TC; 12.8% and 16.2%, respectively), while significantly (p < .01) increasing (p < .001) high-density lipoprotein cholesterol (HDL-C) by 14.6% and 29.1%, respectively ... No serious adverse experiences occurred in policosanol patients (p <
.01), compared with seven adverse experiences (7.9%) reported by placebo patients"
- A long-term study of policosanol in the treatment of intermittent claudication - Angiology 2001 Feb;52(2):115-125 -
"After 6 months of therapy, policosanol significantly increased (p < 0.01) the initial claudication distance from 125.9 +/- 8.7 m to 201.1 +/- 24.8 m and the absolute claudication distance from 219.5 +/- 14.1 m to 380.7 +/- 50.2 m. Both variables remained unchanged in the placebo group (p < 0.01). These effects did
not wear off but improved after long-term therapy, so that final values were 333.5 +/- 28.6 m (initial claudication distance) and 648.9 +/- 54.1 m (absolute claudication distance); both significantly greater (p < 0.0001) than those obtained in the placebo group, which showed values of 137.9 +/- 21.8 m (initial
claudication distance) and 237.7 +/- 28.1 m (absolute claudication distance), respectively"
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