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Home > Anti-aging Research > Aspirin.

Aspirin

Specific Recommendations:

• Drugstore.com aspirin products

CME:

• Aspirin for the Primary and Secondary Prevention of Cardiovascular Events: Therapeutic Use and Advances - PowerPak.com, exp. 7/1/04
• Underutilization of Aspirin in Cardiovascular and Cerebrovascular Diseases - Physician - PowerPak.com, exp. 12/1/03

News & Research:

• Regular Low Dose Aspirin Cuts Asthma Risk In Women - Science Daily, 3/12/08
• Aspirin Could Reduce Breast Cancer And Help Existing Sufferers, Review of Studies Suggests - Science Daily, 3/6/08 - "Anti-inflammatory drugs like aspirin may reduce breast cancer by up to 20 per cent"
• Aspirin Associated With Reduced Colorectal Cancer Risk in Men - Medscape, 2/12/08 - "men who reported regular aspirin use (at least 2 times per week) had a significantly lower risk of colorectal cancer compared with those who were not regular aspirin users (multivariate RR, 0.79) ... However, men reporting 6 to 14 standard aspirin tablets per week had a multivariate RR of 0.72, and those consuming more than 14 tablets per week experienced a multivariate RR of 0.30" - Note: A RR of 0.79 is a 21% reduction, a RR of 0.30 is a 70% reduction.
• High-dose NSAIDs May Prevent Colon Cancer - oncologystat.com. 2/5/08 - "people who took more than 2325 mg of aspirin weekly reduced colon cancer risk by 21%, compared to people who took less aspirin. Men who took 7 to 14 aspirins a week had a 28% decreased risk, and those who took more than 14 aspirins weekly had a 70% decrease in their risk of developing the disease. The advantages were only seen after 5 years of use, and taking less than 1½ pills weekly did not reduce the risk of developing the disease. The effect was also seen with the use of other NSAIDs, such as ibuprofen and naproxen"
• Regular, Long-Term Aspirin Use Reduces Risk of Colorectal Cancer - Doctor's Guide, 1/23/08 - "the benefit of aspirin was not apparent until after more than five years of use. The greatest reduction in risk was observed at cumulative doses of more than 14 standard tablets (325 mg) per week, which is higher than normally recommended. The benefit of aspirin use appears to diminish less than four years after stopping use and is not evident after four to five years of discontinued use"
• Aspirin Limits Prostate Cancer Therapy - WebMD, 12/26/07 - "Abnormal liver-function tests forced some of the men to quit Eulexin treatment before they could finish the six-month study. This happened to 37% of men taking aspirin, but only to 16% of the men not taking aspirin"
• Over-the-counter Pain Medications May Reduce Risk Of Parkinson's Disease - Science Daily, 11/5/07 - "regular users of non-aspirin NSAIDs reduced their risk of Parkinson's disease by as much as 60 percent compared to non-regular users and non-users. Women who were regular users of aspirin reduced their risk of Parkinson's disease by 40 percent, especially among those who regularly used aspirin for more than two years"
• Aspirin -- Just For Men? - Science Daily, 10/17/07 - "Trials that recruited predominantly men demonstrated the largest risk reduction in non-fatal heart attacks ... The trials that contained predominately women failed to demonstrate a significant risk reduction in these non-fatal events. We found that a lot of the variability in these trials seems to be due to the gender ratios, supporting the theory that women may be less responsive to aspirin than men for heart protection"
• Low-Dose Aspirin Plus Statins Protects Against Colorectal Cancer - Medscape, 10/4/07 - "Dr. Brenner's group observed a modest risk reduction of colorectal cancer among regular users of low-dose aspirin (adjusted odds ratio = 0.77). A stronger association was found with regular use of statins (OR 0.65). The strongest risk reduction was seen in subjects who used combination low-dose aspirin and statins (OR 0.63), especially if both drugs were used for at least 5 years (OR 0.38)"
• Adult-Strength Aspirin Cuts Cancer Risk - Physician's Weekly, 7/16/07 - "Patients who had a daily intake of adult-strength aspirin (325 mg or more) for at least 5 years had a 15% lower overall risk of developing cancer. “Long-term daily aspirin use was associated with lower incidence of colorectal cancer (rate ratio = 0.68 among men and women combined) and prostate cancer (rate ratio = 0.81) and a non–statistically significant lower risk of female breast cancer (rate ratio =0.83)"
• Aspirin May Help Fight Cancer - WebMD, 6/5/07 - "Compared with women who never used aspirin, aspirin users were 13% less likely to die of cancer, 25% less likely to die of heart disease, and 18% less likely to die of any cause during the study"
• Aspirin's Colorectal Cancer Prevention Mechanism Revealed - Science Daily, 5/23/07
• Aspirin May Stop Colon Cancer - WebMD, 5/10/07 - "people who took a full-dose aspirin tablet every day for at least five years had as much as a 74% lower risk of colon cancer 10 to 14 years later. In the U.S."
• Baby Aspirin May Be Best for Heart - WebMD, 5/8/07 - "The review shows that aspirin doses greater than 81 milligrams per day haven't been proven better than baby aspirin for the heart and may increase the chances of stomach bleeding"
• Aspirin May Protect Against Cancer - WebMD, 4/17/07
• Can Aspirin Help Keep Cancer At Bay? - Science Daily, 4/16/07 - "those who said they regularly used aspirin had a 16 percent reduced risk of developing cancer more than a decade later, as well as a 13 percent reduced risk of dying from cancer over this same time period, compared to women who did not use aspirin. But there was no statistically significant impact on cancer incidence or mortality among women who used non-aspirin NSAIDs"
• Too Few Take Aspirin for Heart Health - WebMD, 4/10/07 - "only 41% of Americans over 40 regularly take aspirin ... expected to see greater than 70% utilization rates"
• Aspirin Or NSAIDs Won't Prevent Colorectal Cancer - Science Daily, 3/20/07
• Aspirin 'blocks prostate problem' - BBC News, 12/9/06 - "taking NSAIDs was found to prevent or delay enlargement of the prostate"
• Aspirin May Be Newest Cancer Drug - WebMD, 10/2/06 - "In test-tube studies, the researchers find that aspirin does what some of the most cutting-edge new anticancer drugs do. It seems to keep newborn cancers from growing the blood vessels they need to become full-blown tumors -- a process called angiogenesis ... anticancer effect may not be due to blocking Cox enzymes at all"
• Aspirin May Cut Enlarged Prostate Risk - WebMD, 8/30/06 - "Men who reported daily use of aspirin or other anti-inflammatory drugs, such as ibuprofen and naproxen, were 25% less likely to develop moderate to severe enlarged prostate symptoms"
• Remarkable Research Uncovers Lifesaving Benefits Beyond Cardiovascular Protection - Life Extension Magazine, 7/06 - "Exciting new research findings support a disease-preventive benefit for aspirin in other potentially lethal conditions such as skin cancer, colon cancer, and Alzheimer's"
• Aspirin for Preventing Flushing from Niacin - Medscape, 6/13/06 - "the impact of flushing can be minimised by careful dose escalation, administering 'extended-release' NA at bedtime, administering ASA 30 min before 'extended-release' NA and avoiding alcohol or hot drinks near the timeof administration"
• New Stroke Guidelines Underscore Importance of Aspirin for Women - Doctor's Guide, 5/17/06 - "aspirin was associated with a 17% reduction in the overall risk of stroke (P = 0.04) and a 24% reduction in the risk of ischemic stroke ... The guidelines do not recommend the use of aspirin for prevention of a first stroke in men"
• Hopkins Study Shows Low-dose Aspirin Suppresses Clumping Of Blood Platelets In Both Sexes - Science Daily, 3/26/06
• Study: Aspirin Can Help Women's Hearts, Too - ABC News, 3/22/06
• Aspirin Cost-Effective at Preventing Heart Disease in More Men Than Previously Thought, Study Shows - Doctor's Guide, 3/6/06
• White Blood Cell Count, Inflammation Linked to Cancer Deaths - Doctor's Guide, 1/24/06 - "those with a higher white blood cell count, a sign of inflammation, were more likely to die of cancer ... The study also suggests that aspirin may have a greater protective effect against cancer for those with high WBC"
• Aspirin Reduces the Risk of Cardiovascular Events in Men and Women, Though Effects Differ Between Sexes - Doctor's Guide, 1/17/06 - "use of aspirin significantly reduces the risk of cardiovascular events in women and in men, due to reducing the risk of stroke in women and reducing the risk of heart attack in men"
• People with Rheumatoid Arthritis Underuse Prophylactic Aspirin - Doctor's Guide, 11/21/05
• Aspirin Reduces Mortality in Women with Stable Cardiovascular Disease - Doctor's Guide, 11/21/05
• Aspirin May Be a Lifesaver for Women - WebMD, 11/17/05 - "During a six-and-a half year period, women taking aspirin were 17% less likely to die from any cause and 25% less likely to die from heart disease, compared with nonusers ... Among the women, the use of aspirin was associated with a 17% reduction in the risk of stroke"
• High Blood Pressure: Nightly Aspirin May Help - WebMD, 9/15/05 - "After three months, these were the results: ... Aspirin at night: Significant drop in blood pressure ... Aspirin in the morning: Slightly higher blood pressure"
• Aspirin Might Prevent Vioxx Cardiac Damage - Science Daily, 9/14/05
• Aspirin May Be OK Before Heart Surgery - WebMD, 8/30/05
• Don't Stop Taking Aspirin Before Heart Surgery - Doctor's Guide, 8/30/05
• High-Dose Aspirin Prevents Colon Cancer - WebMD, 8/23/05
• Long-Term, Regular Aspirin Use Associated With Significant Reduction in Colorectal Cancer Risk Among Women - Doctor's Guide, 8/23/05 - "Among women who regularly used aspirin (2 or more standard [325-mg] tablets per week), there was a 23% reduced relative risk for colorectal cancer compared with nonregular users. However, significant risk reduction was not observed until more than 10 years of use"
• Aspirin Treatment Failure Warning - Science Daily, 8/14/05
• Aspirin Resistance and Its Implications in Clinical Practice - Medscape, 7/11/05
• Aspirin May Cut Prostate Cancer Risk - WebMD, 7/5/05 - "Those who had taken aspirin regularly for a long time were 15% less likely to be diagnosed with prostate cancer. Other anti-inflammatory drugs were associated with an 18% lower risk of prostate cancer"
• Should Everyone Over 50 Take Aspirin? - WebMD, 6/16/05
• Aspirin Ups Risk of Hospitalization for Asthma - WebMD, 5/26/05
• Aspirin May Prevent Colon Cancer Recurrence - Doctor's Guide, 5/20/05 - "Recurrence-free survival was 55% lower in aspirin users than non-users (95% CI, 0.21-0.96), disease-free-survival was 54% lower (95% CI 0.23-0.95), and overall survival was 51% lower"
• Aspirin Therapy in Elderly: Risks vs. Benefits - WebMD, 5/19/05 - "heart disease protection gained from low-dose aspirin use may be offset by serious cases of bleeding. Nelson and colleagues write that the overall balance of harm and benefit "could tip either way.""
• Common Drug Treats Migraine - CBS 2 Chicago, 5/19/05 - "acute migraines are likely to be helped by simple old aspirin"
• Aspirin Prevents Colon Cancer Return - WebMD, 5/16/05
• Aspirin, COX-2 Inhibitors Effective as Adjuvant Therapy in Stage III Colon - Medscape, 5/16/05 - "The chemotherapy provides about 35% improvement in survival compared with surgery alone for that stage of colon cancer, Dr. Fuchs said in an interview. In comparison, aspirin or the two cyclooxygenase 2 (COX-2) inhibitors produced a reduction in risk of recurrence and death that was about 50% beyond what was achieved by chemotherapy after surgery"
• Aspirin-a-day call for over 50s - BBC News, 4/13/05
• Aspirin Beats Coumadin for Brain Blockage - WebMD, 3/30/05 - "Aspirin is safer and no less effective than Coumadin for treating dangerously blocked brain arteries ... many patients with blocked brain arteries may be able to avoid the expense and complications of treatment with Coumadin (also known by its generic name, warfarin)"
• Aspirin Sensitivity Found in More Than One Quarter of Cardiac Patients on Aspirin Therapy - Medscape, 3/14/05
• Baby Aspirin Safer for Preventing Heart Attack - WebMD, 3/10/05 - "The new study shows that taking more than 100 mg of aspirin a day increases the risk of bleeding -- from nose bleeds to bleeding in the brain"
• Study: Aspirin Impacts Women Differently Than Men - washingtonpost.com, 3/7/05
• Challenging the Clinical Significance and Relevance of “Aspirin Resistance” - Physician's Weekly, 12/6/04
• Aspirin May Delay Prostate Cancer, Extend Life - WebMD, 10/4/04 - "more than nine in 10 men who took aspirin or another NSAID were alive 10 years later compared with fewer than seven in 10 men who didn't take the painkillers ... evidence is mounting that prostate cancer may develop in areas with chronic inflammation"
• Daily Aspirin for Heart May Not Work for Some - WebMD, 7/21/04
• Research Shows Aspirin Therapy Didn't Work in Almost Half of Stroke Patients Studied - Doctor's Guide, 7/20/04 - "nearly half of patients who suffered a stroke or transient ischemic attack (TIA) after having been committed to aspirin therapy were "aspirin resistant," meaning the aspirin wasn't producing the antiplatelet (blood-thinning) effect needed to avoid these health threats"
• Too Few Women Take Aspirin to Protect Heart - WebMD, 6/1/04 - "Regardless of their heart disease risk, women were far less likely than men to take aspirin. Just 46% of the high-risk women took aspirin regularly for their hearts, compared with 59% of high-risk men"
• Aspirin May Protect Against Breast Cancer - WebMD, 5/25/04 - "taking aspirin at least once a week for six months or longer reduced the risk of breast cancer by 20%, compared with women who never took aspirin. Taking a daily aspirin reduced risk by more than 25%"
• Uncoated Aspirin May Be Best for Heart Protection - WebMD, 5/6/04
• Statins Fight Vision Loss - WebMD, 4/15/04 - "Patients taking aspirin were 37% less likely to develop this new blood vessel growth"
• Statins and Aspirin May Protect Against Severe Vision Loss in Elderly - Doctor's Guide, 4/13/04 - "Those already on aspirin were about 40 percent less likely to develop this new blood vessel growth, technically called choroidal neovascularization"
• Aspirin May Ward Off Some Cancers - WebMD, 2/17/04 - "regular aspirin use may prevent Hodgkin's disease ... The finding holds true only for aspirin and not for other drugs of its class such as ibuprofen ... aspirin is the key to preventing esophageal cancer" - See Drugstore.com aspirin products.
• Aspirin Use May Prevent Colon Cancer - WebMD, 2/2/04 - "Regularly taking aspirin -- more than two tablets a week -- reduced the risks of polyps by 25% ... while higher doses of aspirin (325 milligrams per day) may be necessary for optimal prevention of polyps, the risk of severe gastrointestinal bleeding remains a serious concern"
• Aspirin Linked to Pancreatic Cancer Risk - WebMD, 1/6/04
• Aspirin Withdrawal Risky in Coronary Patients - Doctor's Guide, 10/31/03
• Regular aspirin use linked to pancreatic cancer - USA Today, 10/28/03 - "women who reported 20 or more years of regular aspirin use, with an average intake of at least two or more tablets a week, had a 58% increased risk of pancreatic cancer, compared to those who did not take aspirin. Among those who took 14 tablets or more a week, the risk was 86% greater"
• Aspirin Raises Pancreatic Cancer Risk - WebMD, 10/28/03
• Overall Evidence Supports Use Of Aspirin In Reducing Risk Of First Myocardial Infarction - Doctor's Guide, 9/26/03
• Aspirin Therapy Helps Prevent First Heart Attack - WebMD, 9/24/03
• Aspirin Therapy: How Much Is Too Much? - WebMD, 9/22/03 - "In this new study, higher doses of aspirin were no more effective than low-dose aspirin therapy at preventing heart attacks and strokes ... Just under 2% of the patients given low-dose aspirin alone experienced life-threatening bleeding events, compared with close to 4% of patients taking more than 200 mg of aspirin a day. Among patients taking aspirin and Plavix, 3% of patients in the low-dose aspirin groups experienced serious bleeding vs. 5% of those in the high-dose aspirin group"
• Studies Suggest Aspirin Resistance is More Common Than Once Believed - Medscape, 9/4/03
• Aspirin Resistance Common in Patients on Daily Preventive Therapy - Doctor's Guide, 9/4/03
• Painkillers Cut Aspirin's Heart Benefit - WebMD, 8/25/03 - "half took 325 mg aspirin on alternate days; half took a placebo ... The aspirin group had 44% fewer heart attacks than the placebo group -- 139 heart attacks in the aspirin group; 239 in the placebo group ... Those who regularly took ibuprofen and other common anti-inflammatory drugs did not get that protective effect" - See Drugstore.com aspirin products.
• Pain Relievers May Prevent Parkinson's - WebMD, 8/18/03
• Prenatal Use of Nonsteroidal Anti-inflammatory Drugs Significantly Increases Risk of Miscarriage - Doctor's Guide, 8/14/03
• Research suggests aspirin could fight rare form of cancer - Doctor's Guide, 8/13/03
• Aspirin Reduces Risk of Leukemia by Half - Physician's Weekly, 8/4/03 - "women who took aspirin two or more times per week were 55% less likely to develop leukemia than those who never used aspirin" - See Drugstore.com aspirin products.
• Aspirin May Lower Adult Leukemia Risk - WebMD, 6/17/03
• Aspirin Reduces Preeclampsia Risk - WebMD, 6/16/03
• Aspirin As Effective As Ticlopidine In African American Antiplatelet Stroke Prevention Study - Doctor's Guide, 6/11/03
• Aspirin May Be Better Than Ticlopidine for Recurrent Stroke Prevention... - Medscape, 6/10/03 - "Ticlopidine (Ticlid; Roche) does not appear to be superior to aspirin in preventing recurrent strokes in African-American patients"
• Night Time Aspirin Regimen Found to Reduce Blood Pressure - Doctor's Guide, 6/4/03 - "Researchers randomly assigned participants to 3 subgroups, which received a regimen of no aspirin, 100 mg aspirin after waking, or 100 mg aspirin before sleeping ... The subgroup following a regimen of evening aspirin administration showed a reduction in the 24 hour mean of 6.2 mm Hg in systolic blood pressure and 4.1 mm Hg in diastolic blood pressure ... the effect was not evident for the subgroups receiving no aspirin or morning administration" - See Drugstore.com aspirin products.
• Use of Non-steroidal Anti-inflammatory Drugs Dramatically Reduces Risk of Breast Cancer - Doctor's Guide, 4/8/03
• Aspirin May Protect Against Parkinson's Disease - Doctor's Guide, 4/4/03 - "Dr. Ross hypothesized that since inflammation is thought to play a role in the neurodegenerative process leading to Parkinson's disease, anti-inflammatory drugs such as aspirin may help slow the progression of the disease ... The study showed that there were 17.7 cases of Parkinson's per 10,000 person-years in the patients who never took aspirin or were taking it on one occasion, compared with 6.8 cases per 10,000 person-years in the men who were taking aspirin on both assessments ... No conclusion could be drawn regarding the use of other NSAIDs and Parkinson's, he said, because too few of the men reported taking the drugs" - See drugstore.com aspirin products.
• More Migraine Relief Seen with Over-the-Counter Combination than with Sumatriptan - Doctor's Guide, 4/4/03 - "Patients are more likely to get relief from a migraine episode if they use an over-the-counter (OTC) treatment that combines acetaminophen, aspirin, and caffeine at the first sign of an attack than if they use 50 mg of sumatriptan (Imitrex) ... Among the OTC subjects, 87% had responded to treatment at 2 hours, compared to 75% of sumatriptan subjects (P=0.045). The differences seen 24 hours after treatment showed that 66% of the OTC subjects had sustained relief, compared to 49% of the sumatriptan group" - See drugstore.com acetaminophen products.
• NSAIDS May Help in Alzheimer's Prevention - WebMD, 4/1/03 - "For those using aspirin, the reduction in risk was 13%, a finding that was not considered significant ... Those on an NSAID for one to 23 months had a risk reduction of 17%, and those termed long-term users, beyond 23 months, reduced the risk of developing Alzheimer's disease by 73%" - See drugstore.com NSAID and aspirin products.
• Non-Steroidal Anti-Inflammatory Drugs Appear To Protect Against Alzheimer's - Doctor's Guide, 4/1/03 - "compared with non-users, people who took any type of NSAID were 28% less likely to develop Alzheimer's, which was statistically significant. But, among aspirin-only users, the risk of Alzheimer's was cut by 13%, which was not significant" - See drugstore.com NSAID and aspirin products.
• Triflusal No Better Than Aspirin In Preventing Vascular Events After Stroke - Doctor's Guide, 3/27/03
• Aspirin Resistance Can Increases Heart Risk For People on Aspirin Therapy - WebMD, 3/19/03
• Aspirin Reduces Colon Cancer, Polyp Risk - WebMD, 3/5/03 - See Drugstore.com aspirin products.
• Low-Dose, Enteric Aspirin Often Fail to Produce Antiplatelet Effect - Doctor's Guide, 2/18/03
• Stroke Trial Halted when Ticlopidine Fails to Outperform Aspirin in African Americans - Doctor's Guide, 2/18/03
• Coated Aspirin Particularly Lacks Blood-Thinning Effect - WebMD, 2/14/03
• Ibuprofen Can Limit Cardioprotective Effects Of Aspirin - Doctor's Guide, 2/13/03
• Ibuprofen Reduces Aspirin's Heart Benefit - WebMD, 2/12/03
• Lower-Potency Mini-Dose Aspirin Kinder To Renal Function - Doctor's Guide, 2/13/03
• Does a Daily Aspirin Really Help? - Dr. Weil, 1/31/03 - "Joe Alpert, MD chairman of the Department of Medicine here at the University of Arizona, notes that any dose from 81 to 325 mg daily can be effective but that the current consensus is 162 mg . Those with a history of gastrointestinal bleeding should be cautious about taking aspirin"
• NSAID Use Linked to Lower Incidence of Alzheimer's - Clinical Psychiatry News, 1/03 - "The largest reduction in risk was among former users of NSAIDs or aspirin who had taken the medications for 2 years or more. The incidence of Alzheimer's disease in that group was 29% of the rate seen in nonusers"
• Large Study Supports Use of Aspirin to Reduce Risk of First Heart Attack - Doctor's Guide, 11/18/02 - "An analysis of five studies supports early findings that patients who use aspirin therapy have a 32 percent reduced risk of first heart attack"
• Non Steroidal Anti-Inflammatories Decrease Risk Of Recurrent Myocardial Infarction In Patients Taking Aspirin - Doctor's Guide, 10/30/02 - "Patients taking aspirin who were also taking NSAIDs were significantly less likely to experience recurrent AMI than those who took only aspirin"
• Pain Relievers May Have Pressure Link - Intelihealth, 10/28/02
• Aspirin Curbs Coronary Bypass Surgery Complications, Deaths - Doctor's Guide, 10/24/02
• Anti-inflammatory Drugs May Require Two Years' Treatment to Prevent Colorectal Cancer - Doctor's Guide, 10/22/02 - "Taking aspirin or an NSAID for at least two years reduced the risk of colorectal cancer by 32 percent"
• Efficacy of Angiotensin Converting Enzyme Inhibitors Not Altered By Aspirin - Doctor's Guide, 10/4/02
• Aspirin Before Bed May Reduce Risk For Preterm Delivery, Gestational Hypertension And Preeclampsia - Doctor's Guide, 9/27/02
• Bedtime Aspirin Lowers Pregnancy Trouble - WebMD, 9/26/02
• Pain Relievers May Prevent Alzheimer's - WebMD, 9/23/02 - "The study found people who took aspirin or other NSAIDs for more than two years before the study began were 45% less likely to develop Alzheimer's than those who didn't. And the longer the participants had taken the drugs, the more protected they were against the disease ... previous studies have suggested that aspirin and other NSAIDs might protect against Alzheimer's disease by reducing inflammation in the brain ... their findings show that the beneficial effects of NSAIDs in preventing Alzheimer's take a long time to accumulate and don't become apparent until years later"
• Aspirin May Negate the Benefits of ACE Inhibitors - Doctor's Guide, 9/13/02 - "Although aspirin (ASA) and angiotensin-converting enzyme (ACE) inhibitors have been shown to reduce ischemic events after myocardial infarction (MI), ASA may attenuate the beneficial effects of ACE inhibitors among patients with CAD or left-ventricular dysfunction ... patients receiving an ACE inhibitor with ASA had a higher rate of death or recurrent MI compared to those receiving ASA alone ... Interestingly, the higher rate of adverse outcomes with this combination was present even in those receiving the 80 mg dose of ASA ... No mechanism for this adverse effect was suggested"
• Low-Dose Acetylsalicylic Acid may Interfere With ACE Inhibition in Type I Diabetics - Doctor's Guide, 9/4/02 - "Low-dose acetylsalicylic acid (ASA, Aspirin) may increase systolic blood pressure in type 1 diabetic patients, especially in those taking angiotensin-converting enzyme (ACE) inhibitors ... Compared to those not taking ASA, patients taking ASA had higher systolic blood pressure (SBP) (151 plus or minus 1 versus 134 plus or minus 1 mmHg; p<0.0001) and diastolic blood pressure (DBP) (84 plus or minus 1 versus 80 plus or minus 1 ... Similarly, in patients without CVD and not taking antihypertensive drugs (n=37), SBP was still higher in those taking ASA (142 plus or minus 3 mmHg) compared to the 1042 participants who were not taking it (128 plus or minus 1 mmHg)"
• More Data Shows Additive Benefits of Aspirin - Medscape Cardiology, 8/2/02 - "aspirin may be able to protect blood vessels from the deleterious effects of inflammation and infection, 2 factors thought to initiate and promote atherosclerosis ... Aspirin may also have a preventive benefit among patients at high risk of ischemic stroke ... patients who took low-dose aspirin before going to bed had a significantly greater reduction in blood pressure than those who took aspirin at other times of the day ... aspirin prevention therapy is best suited for people at high risk of developing CHD (those with a 5-year risk of >/= 3%), since the benefits of aspirin use in this patient population significantly outweigh the risks"
• Aspirin Lowers Pancreatic Cancer Risk - WebMD, 8/6/02 - "A new study shows regular use of aspirin might lower your risk of one of the deadliest forms of cancer ... women who used aspirin cut their risk of developing pancreatic cancer nearly in half ... the more aspirin use a woman reported, the less likely she was to develop pancreatic cancer ... Other NSAIDs did not have the same effect"
• An Aspirin (ASA) A Day Keeps First Heart Attack Away - Health Canada Confirms It - Doctor's Guide, 7/31/02
• Aspirin May Improve Glucose Tolerance In Type 2 Diabetes Through Serine Kinase Inhibition - Doctor's Guide, 6/4/02
• Low-Dose Aspirin Does Not Interfere With Antihypertensive Agents - Doctor's Guide, 6/4/02
• Take Aspirin at Night for Heart Benefits - WebMD, 5/15/02 - "Aspirin didn't affect blood pressure if given in the morning. But when given at night, it had a significant effect: a 7.0 mmHg decrease in systolic blood pressure (the top number in a blood-pressure reading) and a 4.8 mmHg decrease in diastolic blood pressure (the bottom number)."
• New Test Predicts Sudden Death Risk - WebMD, 4/15/02 - "those who suffered sudden cardiac death had higher levels of a substance called C-reactive protein (CRP) ... CRP is released when blood vessels are inflamed ... the findings of this study show that the levels of CRP in the blood are even more telling than once thought ... we can intervene with lifestyle counseling and drugs like statins and aspirin"
• Baby Aspirin Lowers Colon Cancer Risk - WebMD, 4/8/02
• Low Dose Aspirin Associated With Reduced Risk For Recurrent Adenomas - Doctor's Guide, 4/8/02
• Aspirin Lowers Colon Cancer Risk - Intelihealth, 4/8/02 - "A daily baby aspirin modestly reduces the risk of colon cancer by preventing the growth of ominous polyps ... the 80-milligram baby aspirin size taken daily reduces this risk by 19 percent ... the researchers found that 38 percent of those getting baby aspirin had new polyps, compared with 47 percent of people getting placeboes. However, little benefit was seen among those getting full-size aspirin. Their recurrence rate was 45 percent"
• Aspirin Resistance Increases Risk of Death from Heart Disease - Doctor's Guide, 3/26/02
• Aspirin no heart attack panacea - USA Today, 3/26/02
• Painkillers Reduce Prostate Cancer Risk - WebMD, 3/13/02
• Daily Aspirin May Help Ward Off Prostate Cancer - Doctor's Guide, 3/12/02
• Scientists Examine Long-Term Risks And Gains Of Painkillers - Intelihealth, 1/22/02 - "The studies reflect scientists' growing interest in the idea that a common condition, inflammation, may underlie many chronic and debilitating diseases - like Alzheimer's, heart disease, osteoporosis and diabetes - and that drugs that fight inflammation may have a role in preventing or delaying those diseases, or at least slowing them down ... Originally, the effect was attributed to aspirin's ability to prevent blood clots, which can cause heart attacks or strokes. But now, researchers think part of the protective effect may come from aspirin's ability to quell inflammation in the arteries, helping to prevent blockages"
• Too Few Take Daily Aspirin - WebMD, 1/14/02
• Aspirin Plus Beta-Blocker Reduce Risk of Post-Myocardial Infarction Deaths in Patients with End-stage Renal Disease - Doctor's Guide, 11/12/01
• Low-dose Aspirin for Essential Thrombocythemia - Doctor's Guide, 10/22/01
• Triflusal Preferable To Aspirin For Secondary Prevention Of Ischemic Stroke - Doctor's Guide, 6/19/01
• An Aspirin a Day to Keep Prostate Cancer Away? - WebMD, 6/7/01 - "A growing body of research has suggested that people who regularly take aspirin and other NSAIDs have a lower risk for cancers, including breast cancer and colon cancer. And though the definitive word is not in, new research presented at the annual meeting of the American Urological Association suggests that regular NSAID use can reduce the risk of prostate cancer too"
• Aspirin Equivalent To Acetaminophen Plus Codeine For Severe Tension Headaches - Doctor's Guide, 4/22/01
• Ulcer Patients Tolerate Aspirin Therapy Following Antibiotics, Therapy Equal to Antiulcer Drug in Preventing Recurrent Ulcer - WebMD, 3/28/01
• Can Aspirin Help Prevent Ovarian Cancer? - WebMD, 3/7/01
• Study Suggests Aspirin Offers Protective Benefit Against Ovarian Epithelial Cancer - Doctor's Guide, 3/7/01
• Frequent aspirin doses cut risk of ovarian cancer - USA Today, 3/6/01 - "Taking aspirin three or more times a week for at least six months appeared to cut women's risk of developing the most common type of ovarian cancer by 40%"
• Studies: Aspirin Safe For Heart - Intelihealth, 2/26/01
• Triflusal As Effective As Aspirin For Preventing Cerebrovascular Events - Doctor's Guide, 2/15/01
• Aspirin Greatly Underutilized Among Patients with Diabetes - WebMD, 2/13/01 - "A simple aspirin is one of the cheapest and most widely available therapies for preventing life-threatening complications of diabetes"
• Aspirin May Ward Off Pregnancy Complication - WebMD, 2/9/01 - "Taking low doses of aspirin could be a good way to prevent dangerously high blood pressure from developing during pregnancy."
• An Aspirin a Day Keeps Stroke Away -- but Don't Overdo It! More Isn't Better When It Comes to Aspirin Therapy, Experts Caution - WebMD, 2/6/01
• Low Dose Aspirin At Least As Effective As High Doses In Preventing Stroke - Doctor's Guide, 1/30/01
• Aspirin-Induced Asthmatics Can Be Successfully Desensitized - Doctor's Guide, 11/15/00
• High Cholesterol Hinders The Effectiveness Of Aspirin - Doctor's Guide, 11/15/00
• Even Low Dose of Aspirin Can Cause Intestinal Bleeding - WebMD, 11/9/00
• Cardioprotective Benefits Of Aspirin Inhibited When Preceded By Ibuprofen - Doctor's Guide, 11/1/00
• COX-2 inhibitors and cancer treatment - Life Extension Magazine, 10/00
• Aspirin Helps Prevent Preeclampsia - Doctor's Guide, 8/25/00
• Early Aspirin May Provide Quick Benefits For Acute Stroke Patients - Doctor's Guide, 6/1/00
• Study Shows Heparin No Better Than Aspirin For Some Stroke Patients - Intelihealth, 4/7/00
• Aspirin As Effective As Orbofiban Or Xemilofiban In Clot-Prevention - Doctor's Guide, 3/14/00
• Aspirin Use Low In Patients With Coronary Artery Disease - Doctor's Guide, 3/14/00
• Aspirin-Not Just for Headaches Anymore - Life Extension Magazine, 2/00
• Aspirin As Effective As Coumadin In Reducing Post-Heart Attack Risk - Doctor's Guide, 11/11/99
• Use Of Antidepressants With NSAIDs Or Aspirin Linked To GI Bleeding - Doctor's Guide, 10/22/99
• Low Doses Of Aspirin Help Prevent Some Strokes, High Doses May Increase Risk For Others - Doctor's Guide, 9/3/99
• Study Raises Questions About Aspirin Safety For Heart Failure Patients - Doctor's Guide, 9/1/99
• Aspirin Alone Protects Some Atrial Fibrillation Patients From Stroke - Doctor's Guide, 4/21/98
• Aspirin Alone Just As Beneficial As Aspirin And Warfarin After Heart Attack - Doctor's Guide, 8/8/97
• Aspirin V Heparin For Stroke -- Aspirin Wins? - Doctor's Guide, 5/30/97
• Alzheimer's Stroke Link Suggests Aspirin's Benefits Says Study - Doctor's Guide, 3/12/97
• FDA Urged to Expand Uses for Aspirin - Doctor's Guide, 1/23/97

Abstracts:

• Aspirin and Folic Acid for the Prevention of Recurrent Colorectal Adenomas - Gastroenterology. 2007 Oct 10 - "In total, 99 (22.8%) of 434 patients receiving aspirin had a recurrent adenoma compared with 121 (28.9%) of 419 patients receiving placebo (relative risk, 0.79"
• Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation - Int J Clin Pharmacol Ther. 2007 Feb;45(2):78-88 - "Aspirin significantly reduced the incidence, intensity and duration of flushing associated with reformulated niacin ER"
• Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer - JAMA. 2005 Aug 24;294(8):914-23
• Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial - JAMA. 2005 Jul 6;294(1):47-55
• Aspirin–Angiotensin-Converting Enzyme Inhibitor Coadministration and Mortality in Patients With Heart Failure - Arch Intern Med. 2003;163:1574-1579 - "the combination of high-dose aspirin with an ACEI was independently associated with the risk of death ... and that the combination of low-dose aspirin with an ACEI was not" - See Drugstore.com low dose aspirin products.

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