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Home > Anti-aging Research > Statins > Pravachol
(pravastatin)
Pravachol (pravastatin)
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News & Research:
-
Low-dose statin therapy reduces risk of CHD in Japanese subjects by 33%
- Medscape, 9/28/06 - "the addition
of pravastatin 10 mg to a low-fat diet rich in omega-3 fatty acids reduces
the risk of CHD in Japanese individuals with moderately elevated cholesterol
levels by 33%, approximately the same reduction observed in US and European
primary-prevention trials that have used larger statin dose"
-
FDA OKs Generic Version of Pravachol - WebMD, 4/25/06 -
"Bristol-Myers Squibb's patent for
the drug expired on April 20. Generic pravastatin tablets (10 milligrams, 20
milligrams, and 40 milligrams) are manufactured by TEVA Pharmaceuticals in
Kfar Sava, Israel"
-
Statins May Lower Blood Pressure - Doctor's Guide, 11/20/04 -
"simvastatin
was associated with a 2.79-mm Hg decrease in systolic blood pressure and a 2.67-mm Hg drop in diastolic blood pressure, while pravastatin led to a 2.47-mm Hg decline in systolic blood pressure and a 2.47-drop in diastolic blood pressure"
- Pravastatin Can Significantly Decrease Systolic Blood Pressure in Moderately Hypertensive Patients With Hyperlipidaemia - Doctor's Guide, 6/17/04 -
"Pravastatin 10 mg/day and probucol 500 mg/day were used during each treatment period ... Systolic blood pressure (BP) decreased significantly by 4.7 mm Hg after
pravastatin treatment"
- Statins Effectively Lower Cholesterol, But Experts Debate First Choice - Medscape, 3/15/04 -
"HDL cholesterol levels were increased more than 10% with
rosuvastatin 40 mg, nearly 5% with atorvastatin 80 mg, 10% with 40 mg simvastatin, and 6.4% with 40 mg pravastatin"
- Pravastatin Therapy May Produce Anti-Inflammatory and Anticoagulant Effects in Patients with Type 2 Diabetes - Doctor's Guide, 2/10/04
- High Dose Atorvastatin Stops Progression of Disease in Patients With Symptomatic Coronary Artery Disease - Doctor's Guide, 11/12/03 -
"After 18
months of treatment, intravascular ultrasound analysis found zero progression in the group treated with atorvastatin, compared with 2.7% progression in the group treated with pravastatin ... atorvastatin stopped plaque progression in each of 22 pre-determined subgroups, while
"we were unable to stop progression in any of the subgroups in the pravastatin arm" - Yeah but the way I read the following, Zocor (simvastatin) not only stopped but reversed progression:
- Pravastatin Treatment Reduces Risk Of Cardiovascular Events For Patients With Diabetes Or Impaired Fasting Glucose - Doctor's Guide, 10/10/03
- Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
"Rosuvastatin significantly more
effective than atorvastatin, simvastatin, and pravastatin in improving the ratios of total cholesterol to high-density lipoprotein cholesterol" - See
Crestor (rosuvastatin)
 at drugstore.com.
- Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol - Doctor's Guide, 9/30/03 -
"Most significantly, while the PWV remained
unchanged in the pravastatin and non-statin group, it was moderately decreased in the simvastatin group and remarkably reduced in the fluvastatin group ... Dr. Ichihara theorized that lipophilic statins, such as fluvastatin, reduce aortic stiffness via three mechanisms
-- decreasing serum total cholesterol levels without reducing serum high-density lipoprotein levels, providing powerful scavenging reactive oxygen species, as well as reducing serum levels of low-density lipoprotein and C-reactive protein" - See
Zocor (simvastatin)
 ,
Pravachol (pravastatin) and
Lescol (fluvastatin) at drugstore.com.
- FDA Approves Pravigard PAC (Buffered Aspirin and Pravastatin Sodium) Tablets For Those At Risk Of Heart Disease, Heart Attack, Or Stroke - Doctor's Guide, 6/25/03
- Pravastatin Plays Significant Role in Preventing Progression of Coronary Atherosclerosis - Doctor's Guide, 3/28/03
- Pravastatin Reduces Left Ventricular Mass Independently of Lipid Lowering Effect - Doctor's Guide, 12/30/02
- Results in Hypertensives with Elevated Cholesterol Similar with Pravastatin, Usual Care - Doctor's Guide, 12/18/02
- Pravastatin Therapy May Help Protect Kidney Function In Patients With Well-Controlled Hypertension - Doctor's Guide, 7/25/02
- Eight Year Follow-Up Shows Safety/Efficacy of Cholesterol-Lowering Pravastatin - Doctor's Guide, 4/22/02
- Pravastatin Mortality Benefit In Patients With And Without Heart Disease - Doctor's Guide, 2/14/02
- FDA Approves Pravachol (Pravastatin) 80 mg for Heart Disease - Doctor's Guide, 2/11/02
- Pravastatin Therapy Decreases the Risk of Stroke - Medscape, 8/3/00
- Pravastatin Appears To Reduce Incidence Of Stroke - Doctor's Guide, 11/9/99
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