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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
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Anti-aging Research > Vitamin E
Vitamin E
Specific Recommendations:
News & Research:
-
Vitamin
E identified as potential weapon against obesity - Science Daily, 4/23/13 -
"The collaborators, from Case Western Reserve
University, the Cleveland Clinic Foundation and Cornell University, discovered
the essential nutrient vitamin E can alleviate symptoms of liver disease brought
on by obesity ... These findings may have a significant impact on public health
... as the vast majority of adults in the United States do not consume the
amount of vitamin E recommended by the National Institute of Medicine ... There
is currently no treatment for NASH, making it one of the most common reasons for
liver transplantation. Manor also points out that "NASH piggybacks on the two
great epidemics of our time: obesity and Type 2 diabetes."" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Excess
vitamin E intake not a health concern, study suggests - Science Daily,
4/15/13 - "a new
review concludes that biological mechanisms exist to routinely eliminate excess
levels of the vitamin, and they make it almost impossible to take a harmful
amount ... A much more important issue is that more than 90 percent of people in
the U.S. have inadequate levels of vitamin E in their diet ... On the other
hand, vitamin E performs many critical roles in optimum health. It protects
polyunsaturated fatty acids from oxidizing, may help protect other essential
lipids, and has been studied for possible value in many degenerative diseases"
- Note: That may be true but everything I've read claims that taking high
amounts of only the alpha-tocopherol lowers the other forms which may be as
important if not more important.
-
How
vitamin E can help prevent cancer - Science Daily, 3/16/13 -
"In this new work, researchers showed in prostate cancer
cells that one form of vitamin E inhibits the activation of an enzyme that is
essential for cancer cell survival. The loss of the enzyme, called Akt, led to
tumor cell death. The vitamin had no negative effect on normal cells ... Vitamin
E occurs in numerous forms based on their chemical structure, and the most
commonly known form belongs to a variety called tocopherols. In this study,
researchers showed that, of the tocopherols tested, the gamma form of tocopherol
was the most potent anti-cancer form of the vitamin ... The researchers began
the work with both alpha and gamma forms of the vitamin E molecule. Both
inhibited the enzyme called Akt in very targeted ways, but the gamma structure
emerged as the more powerful form of the vitamin"
-
Vitamin
E may lower liver cancer risk - Science Daily, 7/17/12 -
"China who were enrolled in the Shanghai Women's Health
Study (SWHS) from 1997-2000 or the Shanghai Men's Health Study (SMHS) from
2002-2006, two population-based cohort studies jointly conducted by the Shanghai
Cancer Institute and Vanderbilt University. Using validated food-frequency
questionnaires, the researchers conducted in-person interviews to gather data on
study participants' dietary habits. They compared liver cancer risk among
participants who had high intake of vitamin E with those with low intake ...
Vitamin E intake from diet and vitamin E supplement use were both associated
with a lower risk of liver cancer. This association was consistent among
participants with and without self-reported liver disease or a family history of
liver cancer"
-
Vitamin
E in diet protects against many cancers, study suggests - Science Daily,
4/23/12 - "Our message is that the vitamin E form of
gamma-tocopherols, the most abundant form of vitamin E in the American diet, and
delta-tocopherols, also found in vegetable oils, are beneficial in preventing
cancers while the form of vitamin E, alpha- tocopherol, the most commonly used
in vitamin E supplements, has no such benefit ... the most commonly used form of
vitamin E supplements, alpha-tocopherol, not only did not prevent prostate
cancer, but its use significantly increased the risk of this disease among
healthy men" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
More vitamin E linked to better mental function: Study - Nutra USA, 1/11/12
- "Alzheimer patients were 85% less likely to have the
highest levels of vitamin E, compared with people with normal cognitive function
... There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma,
delta) and four tocotrienols (alpha, beta, gamma, delta) ... the new study is
said to be the first to evaluate all the forms of vitamin E in relation to
Alzheimer’s disease ... Consumers should be taking a full spectrum vitamin E
especially for improving/ preserving cognitive health and performance" -
[Abstract]
-
Scientists identify an innate function of vitamin E - Science Daily,
12/20/11 - "Everyday activities such as eating and exercise can tear the plasma
membrane and the new research shows that vitamin E is essential to repair.
Without repair of muscle cells, for example, muscles eventually waste away and
die in a process similar to what occurs in muscular dystrophy ... Vitamin E
appears to aid repair in several ways. As an antioxidant, it helps eliminate
destructive byproducts from the body's use of oxygen that impede repair. Because
it's lipid-soluble, vitamin E can actually insert itself into the membrane to
prevent free radicals from attacking. It also can help keep phospholipids, a
major membrane component, compliant so they can better repair after a tear"
-
Elevated Risk for
Prostate Cancer Found With Vitamin E - Medscape, 11/22/11 -
"vitamin E (400 IU) ... The overall risk for
prostate cancer was significantly elevated (by 17%) in the vitamin E group"
- Note: It's the alpha-tocopherol that's measured in IU like that and it's
the form in most supplement. Here's what I take:
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb
-
Combination Antioxidant
Therapy May Help Fatty Liver - Medscape, 11/7/11 - "A combination of vitamin
E and alpha lipoic acid (ALA) can improve the inflammatory and steatosis scores
in patients with nonalcoholic fatty liver disease or nonalcoholic
steatohepatitis ... combination therapy resulted in a 70% difference in change
in tumor necrosis factors-alpha levels from baseline. ... ALA alone or vitamin E
alone were not as effective ... Nonalcoholic fatty liver disease is the most
common liver disease in the world ... In the United States, 20% of the general
population and 75% to 92% of the morbidly obese population suffer from the
disease" - See
Alpha lipoic acid products at iHerb
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Listen up! Antioxidants may slash risk of hearing loss, says study - Nutra
USA, 7/19/11 - "People with the highest average intakes
of vitamin A had a 47 percent reduced risk of moderate or greater hearing loss,
compared to people with the lowest average intakes ... In addition, increasing
dietary vitamin E intakes were linked with a 14 percent reduction in hearing
loss"
-
'Gifted'
natural vitamin E tocotrienol protects brain against stroke in 3 ways -
Science Daily, 7/5/11 - "This is one of the first studies to provide evidence
that a safe nutrient - a vitamin - can alter microRNA biology to produce a
favorable disease outcome ... Here, a natural nutritional product is
simultaneously acting on multiple targets to help prevent stroke-induced brain
damage. That is a gifted molecule" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Preventive use of one form of natural vitamin E may reduce stroke damage -
Science Daily, 7/5/11 - "Vitamin E occurs naturally in eight different forms,
and this work led by Ohio State University scientists is focused on the
tocotrienol form, also known as TCT. The commonly known form of vitamin E
belongs to a variety called tocopherols. TCT is not abundant in the American
diet but is available as a nutritional supplement. It is a common component of a
typical Southeast Asian diet ... In the study, 24 hours after a stroke, lesions
indicating brain tissue damage were about 80 percent smaller in dogs that
received supplementation than were the lesions in dogs that received no
intervention. Imaging tests showed that the treated animals' brains had better
blood flow at the stroke site as compared to untreated dogs' brains, a
difference attributed to tiny collateral blood vessels' ability to improve
circulation in the brain when blood flow stopped in more substantial vessels ...
In the study, 20 dogs were randomly assigned to one of two groups: those
receiving a placebo pill, and those receiving 200 milligrams of mixed
tocotrienols ... Additional examination of the affected brain tissue showed that
the TCT supplementation appeared to support arteriogenesis, a process by which
collateral arteries remodel themselves into larger vessels so they can bypass
the site of blockage" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Vitamin E tocotrienols show cholesterol benefits for healthy adults: Study -
Nutra USA, 6/29/11 - "Daily supplements of a palm oil-based tocotrienol-rich
product increased the ratio of HDL cholesterol to total cholesterol – reported
to be the most specific lipid risk factor for cardiovascular disease (CVD) – by
14 percent in people over 50, compared to a decrease of about 5 percent in the
placebo group ... HDL cholesterol increases of the magnitude observed in this
study have been associated with a 22.5 percent reduced risk of cardiovascular
events" - [Abstract] -
See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Vitamin E tocotrienols may reduce cholesterol: RCT data - Nutra USA, 5/9/11
- "Supplements containing a mixture of tocotrienols – forms of vitamin E – may
reduce cholesterol levels by about 15 percent in people with raised cholesterol
... Overall, there are eight forms of vitamin E: four tocopherols (alpha, beta,
gamma, delta) and four tocotrienols (alpha, beta, gamma, delta).
Alpha-tocopherol (alpha-Toc) is the main source found in supplements and in the
European diet, while gamma-tocopherol (gamma-Toc) is the most common form in the
American diet ... After four months of supplementation, the researchers noted a
decrease in total cholesterol of 9 percent, with the decrease recorded as 11
percent after six months ... In addition, LDL cholesterol levels were decreased
by 13 and 17.5 percent after four and six months of supplementation,
respectively" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Vitamin
E helps diminish a type of fatty liver disease in children, study suggests -
Science Daily, 4/27/11 - "Nonalcoholic fatty liver disease (NAFLD) is the most
common chronic liver disease among U.S. children. NAFLD ranges in severity from steatosis (fat in the liver without injury) to nonalcoholic steatohepatitis or
NASH (fat, inflammation, and liver damage). Fatty liver increases a child's risk
of developing heart disease and liver cirrhosis ... after 96 weeks of treatment,
58 percent of the children on vitamin E no longer had NASH, compared to 41
percent of the children on metformin (a diabetes drug), and 28 percent on
placebo. Vitamin E was better than placebo because it significantly reduced
enlargement and death of liver cells ... These results suggest that vitamin E
improves or resolves NASH in at least half of children, which we previously
showed to be true in adults"
-
Long-Term Vitamin E Intake Linked to Reduced ALS Risk - Medscape, 3/29/11 -
"For dietary vitamin E intake, the adjusted RR comparing the highest quartile
with the lowest was 0.79"
-
Vitamin E May Affect
the Life Expectancy of Men - Medscape, 2/23/11
-
Essential oil pill prevents PMS, study suggests - Science Daily, 1/16/11 -
"Women who were given capsules containing 2 grams of a
combination of gamma linolenic acid, oleic acid, linoleic acid, other
polyunsaturated acids and vitamin E reported significantly eased PMS symptoms at
both 3 and 6 months after they began the treatment" - See
borage oil products at iHerb
(GLA) and
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
Oleic acid is omega-9 in which olive oil is a good source. Linoleic acid
is omega-6. Most Americans get about 10 to 20 times too much omega-6 to
begin with. I don't know why they included it. It makes me wonder
about some of the researchers. If they are showing a benefit, I would
guess it's from the other ingredients and not the omega-6. Gamma linolenic
acid is an omega-6 also but it's a form that most don't get enough of.
-
The science of the ‘next generation’ vitamin E - Nutra USA, 11/3/10 -
"there
are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and
four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is
the main source found in supplements and in the European diet, while
gamma-tocopherol (gamma-Toc) is the most common form in the American diet ... In
terms of benefits to the body, [tocotrienols] would protect a larger area of
membrane in a cell, than a tocopherol that stays stationary in one place ...
Heart disease ... Cancer ... Immune health ... Brain health ... Male pattern
baldness" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Vitamin E tocotrienols show immune boosting potential - Nutra USA, 10/27/10
- "TocominSupraBio ... there are eight forms of
vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols
(alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source
found in supplements and in the European diet, while gamma-tocopherol
(gamma-Toc) is the most common form in the American diet ... Results showed significant increases in levels of the anti-TT antibody,
interferon (IFN)-gamma and interleukin (IL)-4 in the tocotrienol group, compared
with placebo" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Vitamin E in front line of prostate cancer fight - Science Daily, 10/23/10 -
"the research team have discovered a particular form of T3, called
gamma-tocotrienol (γ-T3), can successfully kill off the prostate cancer CSCs ...
Other research has found γ-T3 is also effective in suppressing other types of
cancer, including breast, colon, liver and gastric ... not all vitamin E
preparations had the active constituent" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Burn
injuries rapidly deplete vitamin E, study finds - Science Daily, 10/20/10 -
"An analysis of eight children with third-degree burns
over much of their body found they lost almost half of their stored vitamin E in
three weeks, even though they were being given about 150 percent of the
recommended daily allowance of vitamin E and other nutrients in a high-calorie
diet ... "the depletion of vitamin E may be a very significant problem in
patients with burn injury" and other forms of severe trauma"
-
Omega-3, vitamins C and E may boost pancreatic health - Nutra USA, 9/9/10 -
"consuming at least 850 milligrams of omega-3 fatty acids per day was associated
with a 53 percent reduction in the risk of pancreatic cancer, compared to
intakes of between 330 and 580 milligrams per day ... According to findings
published in the International Journal of Cancer, benefits were also observed
for intakes of vitamin C and E, the highest average intakes associated with 31
and 33 percent reductions, respectively, compared with the lowest average
intakes" - [Abstract]
-
Eating foods rich in vitamin E associated with lower dementia risk - Science
Daily, 7/12/10 - "the one-third of individuals who consumed the most vitamin E
(a median or midpoint of 18.5 milligrams per day) were 25 percent less likely to
develop dementia than the one-third of participants who consumed the least (a
median of 9 milligrams per day)"
-
High
blood levels of vitamin E reduces risk of Alzheimer's, Swedish study finds -
Science Daily, 7/7/10 - "High levels of several vitamin E components in the
blood are associated with a decreased risk for Alzheimer's disease (AD) in
advanced age, suggesting that vitamin E may help prevent cognitive deterioration
in elderly people. This is the conclusion reached in a Swedish study ... Vitamin
E is a family of eight natural components, but most studies related to
Alzheimer's disease investigate only one of these components, ±-tocopherol ...
We hypothesized that all the vitamin E family members could be important in
protecting against AD ... subjects with higher blood levels of all the vitamin E
family forms had a reduced risk of developing AD, compared to subjects with
lower levels. After adjusting for various confounders, the risk was reduced by
45-54%, depending on the vitamin E component" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Finally, Vitamin E May Work -- And It's in the Liver - Medscape, 7/6/10 -
"We used to call this "fatty liver"; now it's got a fancier name -- it's
"nonalcoholic steatohepatitis." ... It turned out that only the Vitamin E group
managed to reach that level of significance"
-
Vitamin E may boost immune function: Mouse study - Science Daily, 5/20/10 -
"The animals were fed 0.1 per cent Tocomin 50 per cent (Carotech), which is a
mixture of tocotrienols and alpha-tocopherols, or a control diet containing only
tocopherol, for six weeks ... Older mice fed the tocotrienol supplement
displayed a greater level of lymphocyte proliferation, a marker of how quickly
white blood cells can reproduce in response to infection, than old mice fed the
control ... mice of both ages fed the tocotrienol supplement had higher levels
of the interleukin-1beta, a cytokine released by immune cells (macrophages). ...
There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta)
and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc)
is the main source found in supplements and in the European diet, while gamma-tocopherol
(gamma-Toc) is the most common form in the American diet" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Long-term use of vitamin E may decrease COPD risk, study finds - Science
Daily, 5/16/10 - "Long-term, regular use of vitamin E in women 45 years of age
and older may help decrease the risk of chronic obstructive pulmonary disease
(COPD) by about 10 percent in both smokers and non-smokers"
-
Vitamin E may be new boon for liver disease - MSNBC, 4/28/10 -
"In the study
published online in the New England Journal of Medicine, 247 adults with
advanced fatty liver disease were randomly assigned to take a high dose of
vitamin E (800 international units), the diabetes drug Actos or dummy pills for
nearly two years ... Biopsies before and after treatment showed that liver
function improved in 43 percent of those in the vitamin E group compared with 19
percent in the placebo group ... participants on the diabetes drug Actos also
improved, but to a lesser degree and with a drawback: gaining 10 pounds on
average, which remained even after they stopped taking the drug"
-
How one
form of natural vitamin E protects brain after stroke - Science Daily,
1/11/10 - "Our research suggests that the different
forms of natural vitamin E have distinct functions. The relatively poorly
studied tocotrienol form of natural vitamin E targets specific pathways to
protect against neural cell death and rescues the brain after stroke injury ...
Vitamin E occurs naturally in eight different forms. The best-known form of
vitamin E belongs to a variety called tocopherols. The form of vitamin E in this
study, tocotrienol or TCT, is not abundant in the American diet but is available
as a nutritional supplement. It is a common component of a typical Southeast
Asian diet" - See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Putting
limits on vitamin E - Science Daily, 12/31/09
-
Antioxidant compound reduced incidence of colorectal metachronous adenomas -
Science Daily, 12/7/09 - "The researchers randomized 411
participants to the placebo group or to receive an antioxidant compound --
specifically selenomethionnine 200 μg, zinc 30 mg, vitamin A 6,000 IU, vitamin C
180 mg and vitamin E 30 mg ... individuals who consumed antioxidants had a 40
percent reduction in the incidence of metachronous adenomas of the large bowel
... It is noteworthy that the benefit observed after the conclusion of the trial
persisted through 13 years of follow up"
-
Antioxidant vitamins may protect against female cancer - Nutra USA, 6/3/09 -
"for every 1,000 microgram increase per 1,000 kcal of
diet of beta-carotene was associated with a 12 per cent reduction in the risk of
endometrial cancer ... Similarly, for every 50 milligram increase per 1,000 kcal
of vitamin C the risk of endometrial cancer was reduced by 15 per cent, and for
every 5 milligram increase per 1,000 kcal of vitamin E the risk of endometrial
cancer was reduced by 9 per cent" - [Abstract]
-
High-Dose Vitamin E Slows Functional Decline in Alzheimer's Disease -
Medscape, 5/4/09 - "The clinical-effectiveness study
enrolled 540 patients with probable Alzheimer's disease (324 women) who had a
mean age of nearly 74 years. All were receiving 1 of the following
cholinesterase inhibitors: donepezil, rivastigmine, or galantamine (800 to 1000
U twice daily). In addition, 208 patients received vitamin E (800 to 2000
IU/day) ... Vitamin E treatment showed small to medium effect sizes in slowing
functional decline, the abstract reports. For vitamin E, the ADL Cohen's d
significantly increased, from 0.20 in year 1 (P = .02) to 0.42 by year 5 (P <
.001)"
-
Vitamin E may reverse male pattern baldness: Study - Nutra USA, 4/28/09 -
"Volunteers were randomly assigned to the palm
tocotrienol complex (total tocotrienol intake of 100 mg) or the placebo (soft
gelatin capsule containing 600 mg soy bean oil) ... Hair counts, measured by the
counting the number of hairs in a pre-selected 2x2 cm area, were found to
significantly increase by an average of 41.8 per cent in the tocotrienol group,
with eight volunteers experiencing greater than 50 per cent hair growth ...
There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta)
and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol is the main
source found in supplements ... While the majority of research on vitamin E has
focused on alpha-Toc, studies into tocotrienols account for less than one per
cent of all research into vitamin E" - See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Tocotrienol build-up in tumours ‘critical’ for anti-cancer benefits: Study -
Nutra USA, 3/31/09 - "the effects of gamma- and
delta-tocotrienol on mouse cancer cells ... the diet supplemented with 0.1 per
cent gamma-tocotrienol or 0.1 per cent delta-tocotrienol for four weeks ... In
conclusion, our results suggested that accumulation is critical for the
anti-tumour activity of tocotrienols" - [Abstract]
- See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Vitamin
E May Decrease Mortality Of Elderly Male Smokers, Yet Increase Mortality Of
Middle-aged Smokers - Science Daily, 2/14/09
-
Vitamin
E Shows Possible Promise In Easing Chronic Inflammation - Science Daily,
12/4/08 - "the larger take-home message of the study,
published in the December issue of the journal Experimental Physiology, is that
Vitamin E “may be beneficial in individuals with chronic inflammation, such as
the elderly or patients with type II diabetes or chronic heart failure"
-
Vitamin E may slash lung cancer risk: Study - Nutra USA, 10/31/08 -
"The researchers calculated that the highest average
intakes of alpha-tocopherol (more than 7.73 mg per day) were associated with a
53 per cent reduction in lung cancer risk, compared to the lowest average
intakes (less than 4.13 mg per day) ... When the researchers accounted for the
other tocopherols they observed no significant associations on lung cancer risk
for beta-, gamma, and delta-tocopherol" - [Abstract]
(see the abstract, I don't believe that last part is true on the gamma. - Ben
-
Optimal
Dose Of Vitamin E Maximizes Benefits, Minimizes Risk - Science Daily,
10/30/08 - "One of the most compelling studies of the
benefits of vitamin E is the Women’s Health Study, in which 40,000 healthy
women, 45 and older, took 600 IU vitamin E supplements or a placebo every other
day for 10 years. Women taking the supplements had 24 percent fewer deaths from
heart disease. Vitamin E’s protective effect appeared even stronger in women 65
and older. Those taking the vitamin experienced a 26 percent reduction in
cardiovascular events and a 49 percent reduction in cardiovascular deaths ...
Vitamin K in the liver appears to diminish as vitamin E increases" -
Note: Alpha-tocopherol is the only form of vitamin E that is measured in
IU's. See my vitamin E page for problems
with just taking the one form of vitamin E. For one thing, in addition to
reducing vitamin K it reduces the gamma-tocopherol form of vitamin E which may
be as important if not more important. See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Prostate Cancer: Vitamin E, Selenium No Help - WebMD, 10/28/08 -
"That evidence included a 1998 Finnish study of whether
vitamin E could prevent lung cancer in some 30,000 smokers. It didn't, but men
taking vitamin E had 32% fewer prostate cancers ... I am afraid it will be the
end of the story for large trials of vitamin E and selenium to prevent prostate
cancer" - Note: Most of the vitamin E studies I've read on prostate
cancer indicated that only the gamma-tocopherol worked yet they spent $114
million on this study and used the cheapest synthetic dl-alpha-tocopherol
acetate form. How dumb was that? I don't know what the story on the
selenium was. Some say it's because people in the U.S. aren't deficient in
selenium. See my comments in my
10/29/08 newsletter.
-
Vitamin E May Help Alzheimer's Patients Live Longer, Study Suggests -
Science Daily, 4/15/08 - "people who took vitamin E,
with or without a cholinesterase inhibitor, were 26 percent less likely to
die than people who didn't take vitamin E"
-
Vitamin C can keep you healthy, looking younger - CNN.com, 2/27/08 -
"Pairing vitamins C and E is smart for another
reason: It may lessen your Alzheimer's risks by as much as 64 percent ..."
-
Vision:
Antioxidants May Cut Cataracts - New York Times, 2/12/08 -
"Compared with the one-fifth of women who consumed
the least antioxidants, the one-fifth who consumed the most reduced their
risk for cataracts by 14 percent with vitamin E and 18 percent with lutein"
-
Vitamin E for Vitality? - WebMD, 1/22/08 - "people
with high blood levels of vitamin E showed a milder decline in their physical
function test scores" - [Science
Daily] - Note: I feel that the reason the studies
stress food as the source is because you are getting the mixed form of vitamin E
instead of the alpha-tocopherol found in most supplements, which may lower the
other forms.
-
Vitamin
E Could Help 40% Of Diabetics Ward Off Heart Attacks - Science Daily,
11/23/07 - "After 18 months of treatment, people with the haptoglobin (Hp) 2-2
gene who took 400 International Units (IU) of vitamin E daily had more than 50
percent fewer heart attacks, strokes, and related deaths than Hp 2-2 patients
who took a placebo pill. 40% of individuals with diabetes carry the Hp 2-2 gene"
- Note: Only the alpha-tocopherol form of vitamin E is measured in IUs and
I'm leery of only taking that form. See:
-
Vitamin E pills may cut heart disease risk in diabetics - Nutra USA,
10/19/07
-
Vitamin supplement use and risk for breast cancer: the Shanghai Breast
Cancer Study - Breast Cancer Res Treat. 2007 Oct 5 -
"a 20% reduction in breast cancer risk was observed
with vitamin E supplement use among women with low-dietary vitamin E intake
... A non-significant 20% risk reduction was observed among vitamin B
supplement users with low B dietary intake (OR = 0.8; 95% CI, 0.6-1.1).
Frequent use of a vitamin B supplement was adversely associated with breast
cancer risk among those with high dietary vitamin B intake (OR = 1.4"
-
Tocotrienol may protect against DNA damage, says study - Nutra USA,
9/24/07 - "There are eight forms of vitamin E: four
tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta,
gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in
supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is
the most common form in the American diet ... While the majority of research
on vitamin E has focused on alpha-Toc, studies into tocotrienols account for
less than one per cent of all research into vitamin E ... blood cells from
patients receiving the tocotrienol-rich supplement had significantly less
DNA damage after three and six months of supplementation than those in the
placebo group" - See my favorite
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Vitamin E Trials 'Fatally Flawed' - Science Daily, 9/23/07
-
Vitamin E May Protect Against Venous Thromboembolism in Women -
Medscape, 9/12/07 - "Of 482 women who had VTE during
follow-up, 213 were in the vitamin E group and 269 were in the placebo
group, yielding a significant 21% hazard reduction (relative hazard, 0.79;
95% confidence interval [CI], 0.66 - 0.94; P = .010). The hazard reduction
was 27% for unprovoked VTE (relative hazard, 0.73; 95% CI, 0.57 - 0.94; P =
.016)"
-
Vitamin E May Lower Blood Clot Risk - WebMD, 9/11/07 -
"Overall, women who took vitamin E were 21% less
likely to develop venous thromboembolism than women who did not, but the
reduction was more than double this (44%) among the women who had a history
of clots ... taking vitamin E appeared to cut the clot risk in half among
women with genetic mutations that increased their risk"
-
Vitamin E's Lack Of Heart Benefit Linked To Dosage - Science Daily,
8/22/07
-
Industry must wake up to tocotrienol opportunities - Nutra USA, 8/1/07 -
"While the majority of research on vitamin E has
focused on alpha-Toc, studies into tocotrienols account for less than one
per cent of all research into vitamin E"
-
Vitamin E: Friend or Foe During Radiation Therapy? - Physician's Weekly,
7/16/07 - "Not only did it show that vitamin E
supplementation was of no benefit to patients, but it was also associated
with a nearly 40% increased risk of death when compared to study
counterparts who received a placebo. Vitamin E, despite what patients may
think, appears to be much more harmful for patients who have head and neck
cancer who are receiving radiation therapy"
-
Pro-vitamin E Shown To Be Active Against Breast Cancer Cells - Science
Daily, 12/9/06 - "pro-vitamin E or
alpha-tocopheryl succinate can reduce tumour volume in experimental animals
with high levels of HER2"
-
Vitamin E may
protect against cancer, heart ills - MSNBC, 11/22/06 -
"Men with the highest levels of
vitamin E in their blood were 18 percent less likely to die than those with
the lowest levels, the researchers found. They also had a 21-percent lower
risk of death from cancer, a 19-percent lower risk of dying from heart
disease, and a 30-percent lower risk of death from other causes"
-
Antioxidant-rich Pecans Can Protect Against Unhealthy Oxidation -
Science Daily, 10/3/06 - "adding
just a handful of pecans to your diet each day may inhibit unwanted
oxidation of blood lipids, thus helping reduce the risk of heart disease.
Researchers suggest that this positive effect was in part due to the pecan's
significant content of vitamin E ... Pecans are especially rich in one form
of vitamin E -- gamma tocopherol"
-
Tocotrienol intake could result in bioactive concentrations - Nutra USA,
7/17/06
-
What Makes Gamma Tocopherol Superior to Alpha Tocopherol
- Life Extension Magazine, 4/06 - "vitamin E
supplements should contain a ratio of alpha tocopherol to gamma tocopherol
that is closer to what is found in nature ... For optimal supplementation,
it would appear logical to consume at least 200 mg of gamma tocopherol each
day, in addition to around 400 IU of alpha tocopherol"
-
Tocotrienols may stop the spread of cancer cells - Nutra USA, 3/16/06
-
Vitamin E – the need for perspective - Nutra USA, 3/9/06
-
The vitamin E debate rumbles on - Nutra USA, 3/7/06
-
Nutritional Friend Or Foe? Vitamin E Sends Mixed Messages - Science
Daily, 3/3/06 - "We think that
gamma-tocopherol may have this kind of damaging effect on nearly every type
of cell in the body"
-
Healthy Diet May Help Seniors' Vision - WebMD, 12/27/05 -
"People with above-average intakes of
all four antioxidants were 35% less likely to develop AMD during the study
... Vitamin E and zinc stood out"
-
Meta-analysis Results Suggest High-Dose Vitamin E Increases All-Cause
Mortality - Medscape, 11/6/05 -
"there are several theories about why vitamin E increases risk. One theory
is that it increases bleeding risk, which would increase the risk of
hemorrhagic stroke, while another theory suggests that at high doses vitamin
E stops working like an antioxidant that mops up free radicals that attack
cells that line blood vessels and instead becomes a prooxidant and actually
promotes the production of free radicals ... Still another scenario suggests
that high-doses of vitamin E tend to destroy other fat-soluble antioxidants"
-
Vitamin E: Alpha or Gamma? - Natural Food Merchandiser, 10/05 -
"Given these synergistic
relationships and the results of research to date, a mixed-tocopherol
product seems to be the best choice"
-
Vitamin E tocotrienol shows brain protection promise - Nutra USA,
10/25/05
-
Low Vitamin E Serum Levels Correlate With Dementia Risk - Clinical
Psychiatry News, 10/05 - "those
individuals in the bottom tertile of vitamin E plasma levels were at
significantly higher risk not only of being demented (OR 2.6, 95% CI) but
also of having impaired cognitive function (OR 2.2, 95% CI), compared with
the highest vitamin E tertile"
-
High
Doses Of Vitamin E Boost Rat Survival Rate 40%; Brain Function,
Neuromuscular Gains - Science Daily, 9/5/05 -
"male mice showed a 40% increase in
median lifespan ... 17% increase in maximal lifespan (to 136 weeks from 116
weeks) ... increases in the ability to perform tests measuring neuromuscular
performance (high-wire tightrope) and cognitive exploratory activity
(T-maze)"
-
Vitamin E Boosts Lifespan, Brain Functioning - mercola.com, 9/2/05 -
"be sure to find a brand that
contains gamma-tocopherol, the most naturally occuring form of vitamin E,
not dl-alpha-tocopherol, the synthetic variety that's most commonly
available in most stores"
-
Are you getting
enough vitamin E? - MSNBC, 8/12/05 -
"Most supplements contain – and thus
most research looks at – the form of vitamin E known as alpha-tocopherol.
However, gamma-tocopherol is actually the major form in the American diet
... Some studies show that blood levels of gamma-tocopherol are a good or
better indicator of heart and cancer risk. Gamma-tocopherol may even have
unique cancer-suppressing functions within cells. Some studies suggest that
alpha-tocopherol supplements may have the undesirable effect of reducing
blood and tissue levels of gamma-tocopherol"
-
Vitamin E Fails to Deliver on Early Promise - New York Times, 8/2/05
-
CRN criticizes vitamin E dosage report - Nutra USA, 7/21/05
-
Many Americans take too much vitamin E, says CDC - Nutra USA, 7/19/05
-
Gamma-tocopherol garners speculation - ffnmag.com, 6/05
-
Can
Rice Bran Oil Melt Away Cholesterol? - Science Daily, 5/12/05 -
"Vitamin E ... consists of both
tocopherols and tocotrienols ... the tocotrienols (TRF) seem to have greater
antioxidant properties ... taking any form of Vitamin E for a long time can
be harmful ... The most effective dose in rats was 8 IU kg/day. Extrapolated
to humans, a person with an average body weight of 154 pounds would get
around 560 IU"
-
Tocotrienol-Rich Rice Bran Oil A New Natural Cholesterol-Fighter -
mercola.com, 5/12/05 - "This good
news certainly supports other studies that have shown the antioxidant
effects of tocotrienols to be 40 to 60 times more effective than alpha
tocopherol"
-
Boost In Immune Response Fights Common Cold - Science Daily, 4/24/05 -
"Nursing facility residents who
consumed 200 International Units (IUs) of vitamin E daily for one year were
less likely to get the sniffles than those who took a placebo ... those who
took the moderate supplements were 20 percent less likely to contract upper
respiratory infections, such as colds"
-
The Fake Controversy Over Vitamin E
- mercola.com, 3/16/05 - "The kind of vitamin E most people often refer to which is
sold in most stores is dl-alpha-tocopherol, and I urge you to stay away from
it"
-
Vitamin E Harms More Than It Helps - WebMD, 3/15/05 [Abstract]
- "All were over age 55. Half got
high-dose vitamin E -- 400 IU every day (about 400 milligrams) -- and half
got fake pills that looked the just the same ... Vitamin E was linked to a
13% higher risk of heart failure and a 21% increased risk of hospitalization
for heart failure" - Note: The way I understand it, only the alpha
tocopherol form (used in most supplements) is measured in IU. So I
assume they used that form for this study. I've been saying for some
time that taking just the alpha tocopherol form causes more harm than good
because it
lowers gamma tocopherol. See item 6 on my
home page. With all the evidence
against alpha tocopherol, I'm surprised they are still using it in studies
and I'm surprised how slow vitamin companies are to offer multi-vitamins
with mixed tocopherols/tocotrienols.
- Vitamin E: Which Type Best for Prostate Cancer? -
WebMD, 3/1/05 -
"the men with the highest blood levels of alpha and gamma tocopherol had
lower prostate cancer risk. Men with the highest levels of both forms of the
vitamin were 30%-40% less likely to develop prostate cancer as those with
the lowest levels"
- Vitamin E From Food Sources May Reduce Risk of AD
- Medscape, 2/11/05 -
"High intake of vitamin E from food (tocopherol), but not from supplements
(which usually contain α-tocopherol), is inversely associated with Alzheimer
disease ... various tocopherol forms rather than α-tocopherol alone may be
important in the vitamin E protective association with Alzheimer disease"
- Vitamin E In Plant Seeds Could Halt Prostate, Lung Cancer, Says Purdue
Scientist - Science Daily, 12/30/04 -
"gamma-tocopherol, which occurs naturally in walnuts, pecans, sesame seeds,
and in corn and sesame oils, inhibits the proliferation of lab-cultured
human prostate and lung cancer cells"
- Vitamin E in Food May Fight Cancer - WebMD,
12/15/04 - "Most supplements provide
a different form of the vitamin, alpha-tocopherol ... Gamma-tocopherol aced
its lab tests. It inhibited the spread of prostate and lung cancer cells
without hurting the healthy cells ... Mixing several forms of vitamin E --
including gamma-tocopherol -- was even better at blocking cancer's spread"
- Gamma-tocopherol halts cancer cells in lab study -
Nutra USA, 12/15/04 -
"Gamma-tocopherol, found naturally in walnuts, sesame seeds and corn, was
found to hold back the proliferation of lab-cultured human prostate and lung
cancer cells, reports the team from Purdue University in the 13 December
online edition of the Proceedings of the National Academy of Sciences
... This could indicate that the vitamin could be used to target lung and
prostate cancer cells without the damaging side effects of chemotherapy"
- Vitamin E, Heart Disease, and Mortality - Dr.
Murray's Natural Facts, 11/12/04
- Carotech Communication Regarding Johns Hopkins vitamin E Meta-analysis
- NPI Center, 11/12/04 - "a high
dosage of alpha-tocopherol alone has been shown to deplete the body's
gamma-tocopherol. Despite alpha tocopherol's action as an antioxidant, gamma
tocopherol is required to effectively remove the harmful peroxynitrite-derived
nitrating species"
- High-Dose Vitamin E May Shorten Life Span - WebMD,
11/10/04 - "too much vitamin E --
daily doses of 400 IU or more -- actually increases the risk of dying"
- Note: Most vitamin E supplements are the d-alpha tocopherol or
dl-alpha tocopheryl (synthetic) form, which have been shown to deplete serum
gamma tocopherol and alpha tocotrienol. I've been saying for some time
that taking just the d-alpha tocopherol causes more harm than good (item 6
on my home page).
- CRN Questions Conclusions Reached by Researchers in Recent Vitamin E
Meta-Analysis - NPI Center, 11/10/04 -
"Most of the trials involved middle-aged to elderly persons who had heart
disease or other serious conditions or were at risk of disease. The placebo
groups had an ACM rate of 1022/10,000 and the high-dose (defined by the
researchers as 400 IU and up) vitamin E subjects had an ACM increase of
39/10,000"
- Vitamin E: Reducing Diabetes Risk? - Physician's
Weekly, 11/8/04 - "Although the
improvement in insulin resistance was temporary, elevations in alanine transferase
liver enzyme were sustained throughout the study period"
- Vitamin E + Lycopene Fights Prostate Cancer -
WebMD, 9/30/04 -
"a combination treatment with low-dose lycopene and vitamin E had the
strongest effect at slowing tumor growth -- a 73% slowing of growth on the
42nd day of the test ... The next best results came from the low dose of
lycopene alone, which slowed tumor growth by 53% in the same time frame"
- Nourishing Your Noggin - WebMD, 9/22/04 -
"For a long time, people believed that a common component of vitamin E
called alpha tocopherol was most important, but another form called gamma
tocopherol is definitely a protective antioxidant in brain disorders"
- Vitamin E review - ConsumerLab.com, 8/25/04 -
"There are studies underway to determine whether gamma-tocopherol (which is
more abundant in the diet than alpha-tocopherol) may be important for some
of the beneficial effects associated with natural vitamin E in the diet ...
32 products were purchased ... Five vitamin E products failed"
- Vitamin E May Prevent Common Cold - WebMD, 8/17/04
-
"Participants in the vitamin E group who completed the study had
significantly fewer common colds and a 20% lower risk of acquiring a cold
than those in the placebo group"
-
Technical Communication from CAROTECH INC, Edison, NJ (In Response to the
latest Scientific Review on Vitamin E, published in the Archives of Internal
Medicine) - NPI Center, 8/1/04 -
"There are 8 forms of vitamin E in nature - 4 forms of tocopherols and 4
forms of tocotrienols (alpha-, beta-, gamma- and delta-tocopherol and
corresponding tocotrienols). The idea that one single form of vitamin E –
alpha-tocopherol out of eight fractions is the “magic” vitamin E and
assuming that the other forms are worthless denies the very fact that nature
put these seven other tocopherols and tocotrienols out there for a reason"
- Vitamin E Useless in Fighting Heart Disease -
WebMD, 7/28/04 - "vitamin E had no
significant effect in reducing the risk of heart attack, stroke, or
heart-related death"
- Study Shows Vitamins C And E Can Prevent Metabolic Damaage In Extreme
Exercise - Science Daily, 7/15/04 -
"ultramarathon
runners who used supplements of vitamins C and E for six weeks prior to their
races totally prevented the increase in lipid oxidation that is otherwise
associated with extreme exercise"
- Vitamin E May Increase 'Bad' Cholesterol -
HealthDay, 5/3/04 - I feel this guy presents a stupid argument. So let
free radicals do their damage because it may raise LDL. Give me a
break.
- Higher Serum Vitamin E Levels Linked to Lower Prostate Cancer Risk
- Doctor's Guide, 3/30/04 -
"Compared with men in the lowest tertile
of alpha-tocopherol levels, men in the highest
tertile were 53% less likely
to develop prostate cancer (P = .05). Men in the highest
tertile of gamma-tocopherol
were 39% less likely to develop the cancer than those in the lowest
tertile"
- Vitamins C and E May Lower Alzheimer's Risk -
WebMD, 1/20/04
- Vitamin Supplement Use May Reduce Effects Of Alzheimer's Disease
- Doctor's Guide, 1/20/04
- Vitamins E and C May Fend Off Alzheimer's -
HealthDay, 1/19/04 -
"those who took extra vitamin E and C were
about 60 percent less likely to develop dementia
and other memory and thinking problems linked with
Alzheimer's as those who didn't use the two supplements ... The effect
appeared only in people who combined the two vitamins"
- Vitamin E May Improve Omeprazole Treatment of Moderate to Severe Erosive
Oesophagitis - Doctor's Guide, 11/11/03
- Vitamin
E Helps People with Sudden Hearing Loss -
Healthwell Exchange Daily News, 10/2/03 -
"one group received vitamin E, 600 IU two times per day, while the other did
not. Treatment was considered successful when
hearing improved by 75% or more ... At follow-up examinations,
successful treatment was noted in 76% of those receiving vitamin E and 56%
of those not receiving vitamin E"
- Vitamin E Supplements Effective Treatment for Mild Hypertension
- Doctor's Guide, 10/1/03 - "Vitamin
E supplements of 200 IU/day improved the
blood pressure status of 70 mild hypertensive
... Subjects who received vitamin E supplements had a 24% decrease in
systolic blood pressure compared to a 1.6% decrease among placebo controls"
- Vitamin Supplements Improve Blood Vessel Function
- Physician's Weekly, 9/8/03 - "In a
study where children with
hyperlipidemia
were given doses of the antioxidants vitamins C
and E, researchers have found that the supplements can significantly improve
blood vessel function ... the test group received 500 mg of vitamin C and
400 IU of vitamin E daily. Both groups saw an 8% decline in LDL cholesterol
and the test group had significant improvement in endothelial function
comparable to the levels of normal healthy children"
- Age-Related Disease: Reduce Risk with Vitamin E, Exercise
- Physician's Weekly, 8/25/03 -
"Free radical cells, which are unstable molecules that damage cells and are
believed to contribute to the development of various diseases, were
significantly reduced when exercise was combined with taking vitamin E.
Moreover, the combined strategies reduced the risk of obesity, hypertension,
and diabetes, all of which worsen free radical cell damage. The researchers
note that after age 40, the body produces more free radicals and fewer
natural antioxidants to fight them, and taking vitamin E supplements can be
beneficial to the well-being of patients"
- Exercise, Vitamin E Combo Can Slow Aging -
HealthDay, 8/11/03 -
"those who exercised regularly and took vitamin E supplements became
healthier and greatly decreased their levels of a blood marker that signals
destruction of certain cells ... people who didn't exercise, but took
vitamin E, had large decreases in oxidative stress and blood pressure ...
Cells, tissues and organs are damaged by the oxidation caused by free
radicals. Previous research has shown that free radicals play a role in the
development of cancer, obstructed arteries, Alzheimer's disease and some 200
other diseases, as well as the aging process itself"
-
Vitamins E and C Lower Kids' Heart Risks - WebMD, 8/11/03
- Can Vitamins Help Kids With High Cholesterol? -
HealthDay, 8/11/03 -
"All of the participants followed the National Cholesterol Education Program
Step II diet for the entire six months of the study ... After an initial
six-week period, the participants were randomly assigned to receive either
500 milligrams of vitamin C and 400
international units of vitamin E per day or placebos for the next six weeks
... The diet had no effect on endothelial dysfunction ... The vitamin
supplements, however, improved endothelial function to almost normal levels"
- [Abstract]
-
E and C May Give Older Women a Mental Edge - Natural Foods Merchandiser,
8/03 - "The
women who had taken vitamin C
and E supplements for more than 10 years scored an average of 1.5 years
younger in cognitive function than those not
taking vitamins. The results were even more marked for those with low
dietary vitamin E intake: Women with the lowest 30 percent of dietary
vitamin E intake who did not take supplements tested two years older in
mental function than women who compensated for low dietary intake with
antioxidant supplements"
-
Protecting Muscle Mass As You Age - Life Extension Magazine, 8/03 -
"researchers gave both young (age 23 to 35) and elderly (age 66 to 78) men
who were in an intensive exercise program either 1000 IU of vitamin E or a
placebo daily for three months. The results showed that both the young and
older men who were taking the daily vitamin E supplements had significantly
less biochemical markers of free radical damage when compared to the men who
were taking placebo"
- Vitamin E, Exercise Prevent Aging Damage - WebMD,
7/31/03 - "Whether they exercised or
not, those taking vitamin E pills had the same reduction in harmful
substances known as free radicals -- unstable molecules that damage cells
and are believed to contribute to the development of some 200 different
diseases, many of them age-related. The levels of a blood marker that
signals free-radical damage were cut in half ... Basically, vitamin E
prevents free radicals from bumping into cell walls and destroying them"
- What do you
think of the new study showing that antioxidants don’t cut the risk of heart
disease - Dr. Weil, 7/14/03 -
"If you want to supplement your diet, take a product that provides as many
members of this family of protective pigments as possible: alpha-carotene,
lutein, zeaxanthin, lycopene, etc. As for vitamin E, most studies use
synthetic alpha-tocopherol. I recommend using natural vitamin E supplements
that provide all four tocopherols and all four tocotrienols"
-
Alpha-Tocopheryl Succinate Seen as Auxiliary Cancer Treatment -
AltMedicine.com, 5/22/03 -
"alpha-tocopheryl succinate has inhibited and killed both human and rodent
cancer
cells in test tubes (in vitro) and later in the living body of rodents (in
vivo)—without causing normal cells to proliferate. So far, tests in living
human bodies have not been conducted"
-
NOW Foods Introduces Advanced Gamma E Complex - NPI Center, 5/22/03 -
"Gamma and alpha tocopherols must
both be present in the correct ratios to provide Vitamin E’s broad range of
benefits"
-
Delta-tocotrienol - The 21st Century Vitamin E? - Dr. Murray's
Newsletter, 3/19/03
- Vitamin E Protects Against Neurotoxicity From Cisplatin
- Medscape, 3/10/03 - "Among 27
patients who completed six cycles of
cisplatin chemotherapy, the incidence of
neurotoxicity was 30.7% in
the group receiving vitamin E compared with 85.7% in the
unsupplemented
group (P
< .01), and the neurotoxicity
that did occur in the supplemented group was less severe (P
< .01)."
- Is there
anything that I can do to aid recovery and reduce soreness [from exercise]?
- Dr. Murray - "Take 3,000-8,000 mg
of vitamin C and 400-800 IU of vitamin E in
divided doses daily"
- Vitamins C and E may enhance effectiveness of insulin for diabetes
- University of California at Irvine, 1/29/03 -
"Boosting
insulin with
vitamins C and E may improve the drug's effectiveness for treating
diabetes ... the popular antioxidant supplements not only enhance
insulin's ability to reduce blood sugar, but also lower the risks of organ
damage that can occur despite insulin treatments"
- Bad Boy in the Blood: CRP - WebMD, 1/15/03 -
"You can lower your CRP levels by doing the same things you would do to
lower your cholesterol levels: lose weight, eat fewer calories and a very
low fat diet, take the cholesterol-lowering drugs known as
statins, and the natural form of vitamin E"
- Vitamins C and E Improve Outcome in Critically Ill Surgical Patients
- New Hope Natural Media, 1/9/03 -
"Five-hundred and ninety-five people admitted to a surgical intensive care
unit (ICU), 91% of whom were victims of trauma, were randomly assigned to
receive standard care (control group) or standard care plus
vitamins C and E. Vitamin E was given
orally in the amount of 1,000
IU
three times per day, and vitamin C was given intravenously in the amount of
1,000 mg three times per day ... The incidence of multiple organ failure was
significantly lower (by 57%) in the group receiving antioxidants than in the
control group (2.7% vs. 6.1%). In addition, the average length of stay in
the ICU was significantly lower (by 17%) in the antioxidant group.
After 28 days, the mortality rate was 44% lower in the antioxidant group
than in the control group (1.3% vs. 2.4%), but this difference was not
statistically significant"
- Antioxidant Vitamins Improve Surgical Outcomes -
Medscape, 12/20/02 - "Compared with
patients receiving standard care, those who received antioxidant
supplementation with alpha-tocopherol and
ascorbate
had a shorter duration of mechanical ventilation and length of ICU stay, and
lower relative risk (RR) of pulmonary morbidity (RR, 0.81; 95% confidence
interval [CI], 0.60 - 1.1) and of multiple organ failure (RR, 0.43; 95% CI,
0.19 - 0.96)"
- HRT, Vitamins C & E Don't Help Heart - WebMD,
11/19/02 - "New research offers
still more evidence that hormone replacement therapy does more harm that
good in older women with heart disease, and it also raises doubts about the
safety of the antioxidant vitamins E and C"
-
How many international units of vitamin E are in the Gamma E
Tocopherol/Tocotrienol product? - Life Extension Magazine, 11/02 -
"The only form of vitamin E that has a standard conversion formula from
milligrams to international units is alpha tocopherol. The other forms of
vitamin E, beta, gamma and delta, do not have a conversion formula and are
therefore listed in milligrams on the bottle ... The point to remember is to
make sure that your daily total intake of vitamin E contains at least 20%
gamma tocopherol. A study in Proceedings of the National Academy of Sciences
(April 1997) suggests that it could be dangerous to take high doses of alpha
tocopherol without also consuming gamma tocopherol"
- Dietary Intake Of Vitamin E May Reduce Risk Of Parkinson's Disease
- Intelihealth, 10/22/02 - maybe the reason supplements didn't work is
because most supplements only have the alpha form, which has been shown to
lower the gamma.
-
Antioxidants May Reduce Alzheimer's Disease Risk - Clinical Psychiatry
News, 10/02 - "Use of vitamins E and
C together—which is what most subjects did—was
associated with an eightfold reduction in prevalence and a fivefold lower
incidence of Alzheimer's disease"
-
More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical
Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy
for reducing Alzheimer's disease (AD) risk
that includes low fat intake and high consumption of
fish and antioxidants, along with
vitamin E,
folic acid, and
vitamins B6 and B12 supplements"
-
Newly Discovered Benefits of Gamma Tocopherol - Life Extension Magazine,
10/02 - "Since taking large doses of
alpha tocopherol depletes plasma levels of
gamma tocopherol, the health-conscious consumer who takes only alpha
tocopherol supplements needs to seriously reconsider this practice ...
Likewise, most vitamin E supplements provide only alpha tocopherol. New
evidence strongly suggests that this is inadequate supplementation ... men
with the highest plasma levels of gamma tocopherol (the top quintile) had
only one-fifth the risk of prostate cancer compared with the men with the
lowest plasma levels" - I still feel that taking only the alpha can do
more harm than good. Here's the referenced Am J Clin Nutr abstract:
- gamma-tocopherol, the major form of vitamin E in the US diet, deserves
more attention - Am J Clin Nutr 2001
Dec;74(6):714-22 -
"Both gamma-tocopherol and
gamma-CEHC, but not alpha-tocopherol, inhibit cyclooxygenase activity
and, thus, possess antiinflammatory properties. Some human and animal
studies indicate that plasma concentrations of gamma-tocopherol are
inversely associated with the incidence of cardiovascular disease and
prostate cancer. These distinguishing features of gamma-tocopherol and
its metabolite suggest that gamma-tocopherol may contribute
significantly to human health in ways not recognized previously. This
possibility should be further evaluated, especially considering that
high doses of alpha-tocopherol deplete plasma and tissue
gamma-tocopherol, in contrast with supplementation with
gamma-tocopherol, which increases both"
- Vitamins C And E Support Breathing Following An Operation
- Intelihealth, 9/12/02 -
"Patients who have recently undergone an operation experience less breathing
problems after being given a cocktail of vitamins
C and E"
- Vitamin E Is Important For Early Prevention Of Cardiovascular Disease In
Middle-Aged Women - Intelihealth, 8/23/02 -
"Low intakes of vitamin E were significantly associated with plaques in the
carotid bifurcations, which are the sites where most early atherosclerosis
begins. Women with the lowest intakes and plasma concentrations of vitamin E
were more than twice as likely to have this type of plaque"
- Natural
Remedies for Osteoarthritis: Now, More than Ever -
New Hope Natural Media, 8/15/02 -
"Other natural substances that have been reported to relieve the symptoms of
OA include vitamin E (600 to 1,200
IU per
day), Devil's claw,
cat's claw and ginger root"
- A Better
Anti-Oxidant Formula? - Dr. Weil, 8/13/02
- High Dose Vitamin E Appears to Reduce Alzheimer's Risk
- Doctor's Guide, 7/24/02 -
"An analysis of data from the Baltimore Longitudinal Study of Aging suggests
that vitamin E intake is associated with a statistically significant
reduction in the risk of Alzheimer's disease
(AD) ... People with the highest quartile of vitamin E intake, 46.5 mg, had
a 26 percent reduction in risk for developing AD."
- Vitamin
E an Effective Treatment for Eczema - New Hope
Natural Media, 7/11/02
- Negative Results in Antioxidant-Heart Study Challenged: A Healthnotes
Newswire Opinion - New Hope Natural Media, 7/11/02
- "Nutrients work in the body as a
team, and all of them must be present in adequate amounts in order to
promote good health. If magnesium, for example, were the weakest link in the
nutritional chain, one would not expect antioxidants to do much good until
the magnesium deficiency was corrected ... Rather than testing only one or a
few nutrients at a time, researchers should use a supplement that contains
all of the nutrients known to promote heart health" - Some of my
concerns: All the vitamin E studies I've read have only used the alpha
tocopherol and taking only the alpha has been shown to
significantly lower the gamma tocopherol. I also feel that the
studies using only beta carotene are pointless. Beta carotene is just
one of over 600 carotenoids and many researchers believe that taking mega
doses of just one carotenoid can cause of deficiency of the others.
- Link Found Between Vitamin E Intake and Immunoglobulin E In Treatment Of
Atopic Dermatitis - Doctor's Guide, 5/31/02 -
"Dietary vitamin E (VE)
could be an excellent tool in treating
atopic
dermatitis"
- Lipoprotein Alterations Impair Vitamin E In Patients With Parenchymal Liver
Cirrhosis - Doctor's Guide, 5/21/02 -
"Significant increases were seen in the plasma maximal oxidation rate in
cirrhotic patients, which was inversely related to the serum
concentration of vitamin E"
-
What's Wrong With Vitamin E? - Life Extension Magazine, 5/02 -
"Most vitamin E supplements consist primarily of alpha tocopherol. Recent
studies indicate that a lot more than alpha tocopherol is needed to protect
against degenerative disease ... To obtain optimal health benefits from
vitamin E, a mixture of tocopherols (alpha, beta, delta, and gamma) and
tocotrienols (alpha, beta, delta, and gamma) are required ...In an animal
model of aging, tocotrienols extended lifespan by 19% ... studies indicate
that high dose alpha-tocopherol supplementation considerably decreases the
absorption of gamma-tocopherol and reduces the effects of tocotrienols"
-
Does Vitamin E Prevent Breast Cancer? - Life Extension Magazine, 5/02 -
"premenopausal
women with a family history who consumed the highest quantity of vitamin E
enjoyed a 43% reduction in
breast cancer incidence compared to only a 16%
risk reduction for women without a family history of breast cancer.[11]
Based on this study, vitamin E appears to protect against genetic-
predisposed breast cancer better than environmental-induced breast cancer.
(Note that nutrients like
indole-3-carbinol may specifically protect against
environmental breast carcinogens.)"
-
Vitamin E Eases Aching Muscles - WebMD, 4/26/02
-
Vitamins Help After Heart Transplant - WebMD, 3/28/02 -
"The plaque-fighting benefits of the
antioxidant supplements were even greater than those found using statin
medications, which have already been shown to slow hardening of the arteries
after transplants. Previous research has shown that antioxidants, such as
vitamin C and E, can promote heart health
by reducing blood clots and keeping the blood vessels flexible"
- Few Vitamins Effectively Prevent or Reverse Skin Damage
- Medscape, 3/02 - "New laboratory
studies suggest vitamin E helps inactivate free radicals, making them less
likely to cause damage"
- How Vitamin E Works - Nutrition Science News,
12/01
-
Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's
Guide, 11/14/01 -
"increasing levels of serum beta- carotene
were associated with significant reductions in systolic
blood pressure, while increasing levels of serum
vitamin C were associated with significant reductions in diastolic
pressure ... In contrast, serum levels of vitamin E were associated with
significant increases in diastolic blood pressure"
-
Everbody's Getting Alzheimer's, Decline Can Happen Fast in Those Over 65
- WebMD, 11/12/01 - "We know that
dementia is extremely common, especially as we age ... He recommends 800IU
twice a day for people who are already have dementia; for older people at
risk, 400IU twice a day. Younger people and people at low risk are advised
to take 400 IU
once a day"
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah
Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene, gamma
tocopherol, vinpocetine, SAMe,
folic acid, carnosine,
glutathione, DMAE, Huperzine A,
probiotics, MSM,
secretagogues, arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
- Vitamin E Prevents - Nutrition Science News, 11/01
- Zinc, Antioxidants Prevent Some Forms of Vision Loss
- WebMD, 10/12/01 - "people at risk
of losing more sight due to a condition called "age-related macular
degeneration" (AMD) could prevent further vision loss by taking a
combination of zinc and antioxidants, including vitamins C and E and
beta-carotene ... The antioxidants were taken once a day at a dose of 500 mg
of vitamin C, 400 IU
of vitamin E, and 15 mg of beta-carotene. Zinc was given as 80 mg of zinc
oxide along with 2 mg of copper in the form of cupric oxide to prevent
anemia, which can occur from too much zinc ... the high levels of dietary
supplements that were taken in this study are very difficult to achieve from
diet alone"
-
A Prescription for Alarm - Nutrition Science News, 9/01 -
"Taking natural vitamin E supplements to reduce levels of C-reactive
protein, an inflammatory compound that increases the risk of heart disease
by 4.5 times. Heart disease is increasingly viewed as a disease of
blood-vessel inflammation"
-
Antioxidants Resolve Radiation Side Effects - Nutrition Science News,
9/01
- Could
Nicotinamide And Vitamin E Have Synergistic Effect And Reduce Insulin Usage?
- Doctor's Guide, 7/11/01 - "The
combination of nicotinamide and vitamin E might have a synergistic effect in
lowering daily insulin usage among newly diagnosed Type 1 diabetics"
-
Vitamin E May Help Prevent Menopause Bone Loss - WebMD, 6/28/01 -
"Treating these rats with vitamin E at a dose comparable to 400 IU in humans
was just as good as estrogen treatment in restoring bone density and weight"
-
Newer Agents Offer Better Hot Flash Control In Breast Cancer Patients -
Doctor's Guide, 4/4/01 - "If hot
flashes are mild and/or the patient is risk averse, vitamin E (800 IU/day)
is reasonable to try, because it is safe, inexpensive, and has some
demonstrated efficacy"
-
The Prediabetic Epidemic - Nutrition Science News, 3/01 -
"Supplements to Regulate Glucose and Insulin ...
Alpha-Lipoic Acid ... Vitamin E ... A British study of 2,000 subjects
with carefully diagnosed heart disease found that people taking 400800 IU
natural vitamin E daily for an average of 18 months had a 77 percent lower
prevalence of heart attacks, compared with people taking placebos ...
Vitamin C ...
Chromium ...
Silymarin" - (I assume that the natural form includes gamma
tocopheryls whereas most US studies I have read use only the alpha, which
has been shown to lower gamma. That's why I feel there is conflicting
studies with vitamin E. - Ben)
-
Vitamin E 2000 - Nutrition Science News, 3/01
-
High-Dose Vitamin E May Help Hearts - WebMD, 3/1/01 -
"Rimm led a study of vitamin E supplements (100 IU/day) in 38,884 men aged
40-75 without heart disease. Those who received vitamin E had a 25%
reduction in risk of heart disease."
-
Cardiologists Take Vitamin E and Recommend it to Their Patients -
Council for Responsible Nutrition, 1/31/01
-
Antioxidant Vitamins Block Homocysteine's Acute Toxic Effects -
Nutrition Science News, 12/00
-
Vitamins C and E May Reduce Risk, Complications of Diabetes - WebMD,
11/15/00
- Vitamin E
Supplements May Help Prevent Stroke In Men With Hypertension - Doctor's
Guide, 11/6/00
- Vitamin E
Reduces Levels Of Protein That Predicts Heart Disease - Doctor's Guide,
10/24/00
-
Combining alpha- and gamma-tocopherol for maximum antioxidant effect -
Life Extension Magazine, 10/00
-
Diabetic Kids May Benefit From Daily Vitamin E - WebMD, 9/26/00
- E
Gets an 'A' at Lowering Risk of Diabetes Complications - WebMD, 7/11/00
- Vitamin E
Works As Anti-Inflammatory Agent In Type II Diabetes
- Doctor's Guide, 7/10/00 - "A high
intake of vitamin E can help reduce heart disease and stroke risk in type II
diabetics"
-
Fat-Soluble Vitamin Absorption Not Threatened by Fat Cutbacks - WebMD,
5/19/00
-
Vitamin E May Prevent Narrowing of the Arteries - Medscape, 4/19/00
- Some Drugs
May Protect Against Alzheimer's, Others Might Increase Risk - Doctor's
Guide, 4/12/00
- Diet May
Prevent Alzheimer's Disease - Doctor's Guide, 4/9/00
-
Contradictory reports on vitamin E raise questions - CNN, 3/29/00
-
Americans Need E - Nutrition Science News, 1/00
-
Cocktails & Vitamin E Improve Memory - Nutrition Science News, 11/99
-
Vitamin E May Lower Cancer Risk - Intelihealth, 10/19/99
-
Essential Nutrients for Endurance Athletes - Nutrition Science News,
5/99
-
Vitamin E may reduce risk of stroke - CNN, 4/21/99
- Vitamins May
Reduce Stroke Risk - Doctor's Guide, 4/20/99
-
Brain Blood Flow, Alzheimer Linked - Intelihealth, 1/26/99
-
Understanding E - Nutrition Science News,
1/99
-
Vitamin E: Weighing the Tocopherols -
Nutrition Science News, 1/99
- Natural
Vitamin E The Supplement Of Choice For Pregnant Women - Doctor's Guide,
3/24/98
- Vitamin E
May Prevent Prostate Cancer
- Doctor's Guide, 3/18/98 -
"long-term use of a moderate-dose vitamin E supplement substantially reduced
prostate cancer incidence and deaths in male smokers"
-
Study: Vitamin E reduces prostate cancer risk, deaths - CNN, 3/17/98
- Vitamin E
May Reduce Smoking Damage In Pregnant Women - Doctor's Guide, 2/5/98
- Vitamins C
And E Temporarily Block Some Harmful Effects Of High-Fat Meal - Doctor's
Guide, 11/25/97
- Vitamin E
May Enhance Effectiveness Of Colorectal Cancer Drug
- Doctor's Guide, 11/20/97
- Vitamin
Supplements May Reduce Colon Cancer Risk - Doctor's Guide, 11/6/97
- Vitamin E
May Prevent Colon Cancer - Doctor's Guide, 11/5/97
- Antioxidant
Vitamins May Improve Cardiac Patient Outcomes - Doctor's Guide, 6/3/97
- Military
Program Proposes Saving Money Through Vitamin Supplementation
- Doctor's Guide, 5/22/97 - "A new
report by the National Defense Council Foundation finds that the federal
government could save up to $6.3 billion annually by increasing the health
of active and retired military personnel through a anti-aging program that
includes the use of vitamin supplementation"
- Vitamin E
Supplements Provide Some Benefit To Immune System In Elderly - Doctor's
Guide, 5/7/97
-
Report: Vitamin E, Parkinson's drug slow Alzheimer's disease - CNN,
4/23/97
- Studies
Indicate Vitamin E May Slow Aging - Doctor's Guide, 3/5/97
- Vitamin E
Protects Against Heart Attacks, Reports Study -
Doctor's Guide, 1/29/97
Abstracts:
-
Low vitamin
and carotenoid levels are related to cerebral white matter lesions - J Nutr
Health Aging. 2013;17(5):456-60 - "To determine the
effects of vitamins and carotenoids on brain white matter lesions (WMLs), we
examined the associations between WMLs with vitamin and carotenoid levels in
Japanese middle-aged and elderly subjects ... Deep white matter lesions (DWLs)
... Lower gamma-tocopherol levels were significantly associated with DWLs in all
subjects. While lower gamma-tocopherol and vitamin C levels were significantly
associated with DWLs in males, lower delta-tocopherol levels were associated
with DWLs in females. The associations between DWLs and lower gamma- and
delta-tocopherol and vitamin C levels were independent of age, hypertension, or
smoking. However, the associations between DWLs and lower alfa-tocopherol were
not significant following adjustments for smoking" - Note: Most
supplements only contain alfa-tocopherol which had no affect. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Atorvastatin
improves erectile dysfunction in patients initially irresponsive to Sildenafil
by the activation of endothelial nitric oxide synthase - Int J Impot Res.
2013 Jan 17 - "This study aimed at comparing the effects
of atorvastatin and vitamin E on erectile dysfunction in patients initially
irresponsive to sildenafil, with investigation into the underlying possible
mechanisms. Sixty patients were randomly divided into three groups: the
atorvastatin group received 80 mg daily, the vitamin E group received 400 IU
daily and the control group received placebo capsules ... glutathione peroxidase
(GPO) ... nitric oxide (NO) ... Both atorvastatin and vitamin E showed a
statistically significant GPO increase (P<0.05) and a statistically significant
IL-6 decrease (P<0.05). Only atorvastatin showed a statistically significant
increase in NO (15.19%, P<0.05), eNOS (20.58%, P<0.01), IIEF-5 score (53.1%,
P<0.001) and Rigiscan rigidity parameters (P<0.01), in addition to a
statistically significant decrease in CRP (57.9%, P<0.01). However, SOD showed a
statistically significant increase only after vitamin E intake (23.1%, P<0.05).
Both atorvatstain and vitamin E had antioxidant and anti-inflammatory
activities. Although activating eNOS by atorvastatin was the real difference,
and expected to be the main mechanism for NO increase and for improving erectile
dysfunction"
-
Associations
of intake of antioxidant vitamins and fatty acids with asthma in pre-school
children - Public Health Nutr. 2012 Oct 1:1-6 -
"Compared with children with the lowest intake tertile for vitamin C and vitamin
E, those in the highest were significantly inversely associated with asthma;
adjusted OR (95 % CI) were 0.35 (0.14, 0.88) and 0.32 (0.12, 0.85),
respectively. A statistically significant trend was also observed. Fruit intake
showed an inverse but insignificant association with asthma. There were no
associations of any type of fatty acids with asthma" - See
Garden of Life, Vitamin Code, Raw Vitamin C, 60 UltraZorbe Veggie Caps at iHerb
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Tocopherols and
tocotrienols plasma levels are associated with cognitive impairment -
Neurobiol Aging. 2012 Oct;33(10):2282-90 - "Vitamin E
includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential
neuroprotective activity. α-Tocopherol has mainly been investigated in relation
to cognitive impairment ... Low plasma tocopherols and tocotrienols levels are
associated with increased odds of MCI and AD" - [Nutra
USA]
-
Effects of
vitamin E on bone turnover markers among US postmenopausal women - J Bone
Miner Res. 2012 Feb 3 - "Increased oxidative stress and
inflammation resulting from aging and declining estrogen levels can lead to
increased bone loss in postmenopausal women. Alpha- and gamma-tocopherol, the
two predominant isomers of vitamin E, have antioxidant and anti-inflammatory
properties, but their effects on bone metabolism have not been well studied in
humans. We examined the associations between dietary and total (diet and
supplements) alpha-tocopherol intake, serum alpha- and gamma-tocopherol levels
and their ratio, and bone turnover markers (BTMs) among postmenopausal women
aged ≥45 years ... serum bone-specific alkaline phosphatase (BAP), a biomarker
of bone formation, and urinary N-telopeptides/creatinine (uNTx/Cr), a biomarker
of bone resorption ... Participants had a mean age of 65.5 ± 0.6 years and over
45% used vitamin E (alpha-tocopherol) supplements in the past month. Vitamin E
supplement users had significantly lower serum gamma-tocopherol, higher serum
alpha-tocopherol levels and higher ratio of serum alpha- to gamma-tocopherol
than nonusers. High serum gamma-tocopherol levels and low ratio of serum alpha-
to gamma-tocopherol were associated with increased BAP levels (P < 0.01 for
both). There were no associations between any of the vitamin E variables and
uNTx/Cr. In conclusion, we hypothesize that gamma-tocopherol may uncouple bone
turnover, resulting in more bone formation than resorption. Vitamin E
supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol
levels and may have negative effects on bone formation. Further research is
needed to investigate the potential anabolic effect of gamma-tocopherol from
food sources on bone" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Oral
Tocotrienols Are Transported to Human Tissues and Delay the Progression of the
Model for End-Stage Liver Disease Score in Patients - J Nutr. 2012 Feb 1 -
"The natural vitamin E family is composed of 8 members
equally divided into 2 classes: tocopherols (TCP) and tocotrienols (TE). A
growing body of evidence suggests TE possess potent biological activity not
shared by TCP. The primary objective of this work was to determine the
concentrations of TE (200 mg mixed TE, b.i.d.) and TCP [200 mg α-TCP, b.i.d.)]
in vital tissues and organs of adult humans receiving oral supplementation ...
α-TE was delivered to human brain at a concentration reported to be
neuroprotective in experimental models of stroke. In prospective liver
transplantation patients, oral TE lowered the Model for end-stage liver disease
(MELD) score in 50% of patients supplemented, whereas only 20% of
TCP-supplemented patients demonstrated a reduction in MELD score. This work
provides, to our knowledge, the first evidence demonstrating that orally
supplemented TE are transported to vital organs of adult humans. The findings of
this study, in the context of the current literature, lay the foundation for
Phase II clinical trials testing the efficacy of TE against stroke and end-stage
liver disease in humans" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Vitamin E is
a MIF Inhibitor - Biochem Biophys Res Commun. 2012 Jan 18 -
"Macrophage
migration inhibitory factor (MIF) is known to contribute to the pathogenesis of
inflammatory hyperalgesia and neuropathic pain ... Vitamin E inhibits not only
the enzymatic activity of MIF but more importantly the biological function of
MIF. Our findings suggest that Vitamin E may be attenuating hyperalgesia and
reducing neuropathic pain at least in part by inhibiting MIF activity"
-
Vitamin E
and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention
Trial (SELECT) - JAMA. 2011 Oct 12;306(14):1549-56 - "Oral selenium (200
μg/d from L-selenomethionine) with matched vitamin E placebo, vitamin E (400
IU/d of all rac-α-tocopheryl acetate) with matched selenium placebo, both
agents, or both matched placebos for a planned follow-up of a minimum of 7 and
maximum of 12 years ... This report includes 54,464 additional person-years of
follow-up and 521 additional cases of prostate cancer since the primary report.
Compared with the placebo (referent group) in which 529 men developed prostate
cancer, 620 men in the vitamin E group developed prostate cancer (hazard ratio
[HR], 1.17; 99% CI, 1.004-1.36, P = .008); as did 575 in the selenium group (HR,
1.09; 99% CI, 0.93-1.27; P = .18), and 555 in the selenium plus vitamin E group
(HR, 1.05; 99% CI, 0.89-1.22, P = .46). Compared with placebo, the absolute
increase in risk of prostate cancer per 1000 person-years was 1.6 for vitamin E,
0.8 for selenium, and 0.4 for the combination" - Note: The study used rac-α-tocopheryl
acetate. See my vitamin E page for several articles regarding taking only
one of the eight forms of vitamin E. See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Natural
Vitamin E {alpha}-Tocotrienol Protects Against Ischemic Stroke by Induction of
Multidrug Resistance-Associated Protein 1 - Stroke. 2011 Jun 30 -
"α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural
vitamin E that is Generally Recognized As Safe certified by the U.S. Food and
Drug Administration ... This work recognizes MRP1 as a protective factor against
stroke. Furthermore, findings of this study add a new dimension to the current
understanding of the molecular bases of α-TCT neuroprotection in 2 ways: by
identifying MRP1 as a α-TCT-sensitive target and by unveiling the general
prospect that oral α-TCT may regulate miR expression in stroke-affected brain
tissue" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Induction of
Apoptosis by γ-Tocotrienol in Human Cancer Cell Lines and Leukemic Blasts From
Patients: Dependency on Bid, Cytochrome c, and Caspase Pathway - Nutr
Cancer. 2011 Jun 9:1 - "Tocotrienols (Toc3) have been suggested to possess
anticancer effects besides antioxidant and antiinflammatory effects. Previous
studies have demonstrated that Toc3 induce apoptosis in epithelial carcinoma.
However, the effects of Toc3 on malignant hematopoietic cells have not yet been
thoroughly investigated. We investigated Toc3-induced apoptosis in human
hematological cancer cell lines. α-, δ-, and γ-Toc3 induced
concentration-dependent apoptosis, and γ-Toc3 demonstrated more effective
induction than the other Toc3 derivatives in HL-60 cells. γ-Toc3 may have
induced apoptosis by activation of the caspase cascade, cytochrome c (Cyt.c)
release, Bid cleavage, and mitochondorial membrane depolarization in HL-60,
NB-4, Raji, and SY-5Y cells. Furthermore, 10-30 μM γ-Toc3 showed cytotoxicity
for leukemic cells from various patients regardless of lymphoblastic,
myeloblastic, or relapsed leukemia, but the cytotoxic effect was weak in normal
mononuclear cells, interestingly. γ-Toc3 may have a role in cancer prevention
and potential for treating hematological malignancies" - Note: The γ is
the gamma symbol.
-
A Dietary
Mixture Containing Fish Oil, Resveratrol, Lycopene, Catechins, and Vitamins E
and C Reduces Atherosclerosis in Transgenic Mice - J Nutr. 2011 Mar 16 -
"Chronic inflammation and proatherogenic lipids are important risk factors of
cardiovascular disease (CVD). Specific dietary constituents such as polyphenols
and fish oils may improve cardiovascular risk factors and may have a beneficial
effect on disease outcomes ... AIDM was evaluated in an inflammation model, male
human C-reactive protein (CRP) transgenic mice, and an atherosclerosis model,
female ApoE*3Leiden transgenic mice. Two groups of male human-CRP transgenic
mice were fed AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for
6 wk. The effects of AIDM on basal and IL-1β-stimulated CRP expression were
investigated. AIDM reduced cytokine-induced human CRP and fibrinogen expression
in human-CRP transgenic mice. In the atherosclerosis study, 2 groups of female
ApoE*3Leiden transgenic mice were fed an atherogenic diet supplemented with AIDM
[0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 16 wk. AIDM
strongly reduced plasma cholesterol, TG, and serum amyloid A concentrations
compared with placebo. Importantly, long-term treatment of ApoE*3Leiden mice
with AIDM markedly reduced the development of atherosclerosis by 96% compared
with placebo. The effect on atherosclerosis was paralleled by a reduced
expression of the vascular inflammation markers and adhesion molecules
inter-cellular adhesion molecule-1 and E-selectin. Dietary supplementation of
AIDM improves lipid and inflammatory risk factors of CVD and strongly reduces
atherosclerotic lesion development in female transgenic mice" - See
resveratrol products at iHerb,
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb,
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex, 60 Softgels
at iHerb,
Green tea products at iHerb
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by
increasing intracellular dihydrosphingosine and dihydroceramide - Int J
Cancer. 2011 Mar 11 - "Although cell-based studies have shown that γ-tocotrienol
(γTE) exhibits stronger anticancer activities than other forms of vitamin E
including γ-tocopherol (γT), the molecular bases underlying γTE-exerted effects
remains to be elucidated ... In agreement with these cell-based studies, γTE
inhibited LNCaP xenograft growth by 53% (P<0.05), compared with 33% (P = 0.07)
by γT, in nude mice. These findings provide a molecular basis of γTE-stimulated
cancer-cell death and support the notion that elevation of intracellular
dihydroceramide and dihydrosphingosine is likely a novel anticancer mechanism"
-
Effect of
vitamins C and E on antioxidant status of breast-cancer patients undergoing
chemotherapy - J Clin Pharm Ther. 2011 Jan 4 - "VCE
(vitamin C 500 mg tablet and vitamin E 400 mg gelatin capsule ... The untreated
group showed significantly lower levels of antioxidant enzymes (P<0·001) and
reduced glutathione (P<0·001), and more extensive lipid peroxidation (P<0·001)
and DNA damage than healthy controls. Similar but less pronounced patterns were
observed in the patients receiving chemotherapy alone. The group of patients
receiving VCE supplementation had all the marker levels moving towards normal
values. Activities of superoxide dismutase, catalase, glutathione-S-transferase
and glutathione reductase, and the levels of reduced glutathione were
significantly increased (P<0·01) while, the levels of malondialdehyde and DNA
damage were significantly (P<0·01) reduced in the VCE supplemented group
relative to those of patients receiving chemotherapy alone as well as relative
to the pretreatment levels"
-
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3
signalling pathway in human hepatocellular carcinoma: potential role as an
anti-proliferative, pro-apoptotic and chemosensitizing agent - Br J
Pharmacol. 2010 Dec 30 - "Overall, these results suggest
that γ-tocotrienol is a novel blocker of the STAT3 activation pathway, with a
potential role in future therapies for HCC and other cancers" - Note: The
γ symbol stands for gamma.
See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Tocotrienols
inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of
female mice - Lipids Health Dis. 2010 Dec 16;9(1):143 -
"The present results
clearly demonstrate that alpha-, gamma-, or delta-tocotrienol treatments inhibit
the chymotrypsin-like activity of 20S rabbit muscle proteasomes ... These
results represent a novel approach by using natural products, such as
tocotrienols as proteasome modulators, which may lead to the development of new
dietary supplements of tocotrienols for cardiovascular diseases as well as
others that are based on inflammation" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
Effects of
supplementation with tocotrienol-rich fraction on immune response to tetanus
toxoid immunization in normal healthy volunteers - Eur J Clin Nutr. 2010 Sep
22 - "Volunteers supplemented with TRF showed a significantly (P<0.05) enhanced
production of interferon-γ and interleukin (IL)-4 by the mitogen or
TT-stimulated leukocytes compared with the control group. Volunteers from the
TRF group produced significantly (P<0.05) lower amounts of IL-6 compared with
the placebo group. Anti-TT IgG production was also significantly (P<0.05)
augmented in the TRF-supplemented group compared with the placebo group" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
-
The value of
tocotrienols in the prevention and treatment of cancer - J Am Coll Nutr.
2010 Jun;29(3 Suppl):324S-333S - "Tocopherols and tocotrienols represent the 2
subgroups that make up the vitamin E family of compounds, but only tocotrienols
display potent anticancer activity" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Palm
oil-derived natural vitamin E alpha-tocotrienol in brain health and disease
- J Am Coll Nutr. 2010 Jun;29(3 Suppl):314S-323S - "the scientific literature on
tocotrienols accounts for roughly 1% of the total literature on vitamin E, thus
warranting further investment and investigation" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Intake
of fatty acids and antioxidants and pancreatic cancer in a large
population-based case-control study in the San Francisco Bay Area - Int J
Cancer. 2010 Oct 15;127(8):1893-904 - "Positive associations were observed for
high levels of the 8 individual saturated fatty acids (4th vs. 1st quartile: ORs
ranged from 1.6 to 2.6; all p(trend) < 0.01), monounsaturated palmitoleic and
oleic fatty acids [OR = 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI: 1.1-1.9); both
p(trend) < 0.01], and polyunsaturated linolenic acid [OR = 1.5 (95% CI:
1.1-2.0); p(trend) = 0.02]. Inverse associations were observed for high levels
of gadolic acid [4th vs. 1st quartile: OR = 0.68 (95% CI: 0.50-0.92); p(trend) =
0.007] and omega-3 fatty acids [>or=0.85 g/day vs. 1st quartile: OR = 0.47 (95%
CI: 0.25-0.90)]. An inverse association was also observed for high total intake
of vitamin C [4th vs. 1st quartile: OR = 0.69 (95% CI: 0.51-0.94); p(trend) =
0.004] and of vitamin E [OR = 0.67 (95% CI: 0.49-0.92); p(trend) = 0.01]"
-
{gamma}-Tocotrienol but not {gamma}-tocopherol blocks STAT3 cell signaling
pathway through induction of protein tyrosine phosphatase SHP-1 and sensitizes
tumor cells to chemotherapeutic agents - J Biol Chem. 2010 Aug 18 -
"We
found that gamma-T3 but not gamma-tocopherol, the most common saturated form of
Vitamin E, inhibited constitutive activation of STAT3 in a dose- and
time-dependent manner and this inhibition was not cell type specific. gamma-T3
also inhibited STAT3 DNA binding ... This vitamin also sensitized the tumor
cells to the apoptotic effects of thalidomide and bortezomib. Overall, our
results suggest that gamma-T3 is a novel blocker of STAT3 activation pathway in
both in vitro and in vivo and thus may have potential in prevention and
treatment of cancers" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Mixed
Tocotrienols Inhibit Prostate Carcinogenesis in TRAMP Mice - Nutr Cancer.
2010 Aug;62(6):789-94 - "mixed-tocotrienol-fed groups had a lower incidence of
tumor formation along with a significant reduction in the average wet weight of
genitourinary apparatus. Furthermore, mixed tocotrienols significantly reduced
the levels of high-grade neoplastic lesions as compared to the positive
controls. This decrease in levels of high-grade neoplastic lesions was found to
be associated with increased expression of proapoptotic proteins BAD (Bcl(2)
antagonist of cell death) and cleaved caspase-3 and cell cycle regulatory
proteins cyclin dependent kinase inhibitors p21 and p27. In contrast, the
expression of cyclins A and E were found to be decreased in mixed-tocotrienol
groups. Taken together, our results show that by modulating cell cycle
regulatory proteins and increasing expression of proapoptotic proteins, mixed
tocotrienols suppress prostate tumorigenesis in the TRAMP mice" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Dietary
Antioxidants and Long-term Risk of Dementia - Arch Neurol. 2010
Jul;67(7):819-25 - "Compared with participants in the lowest tertile of vitamin
E intake, those in the highest tertile were 25% less likely to develop dementia
(hazard ratio, 0.75"
-
Gamma-tocotrienol as an effective agent in targeting prostate cancer stem
cell-like population - Int J Cancer. 2010 Jul 8 - "Emerging evidence
supports that prostate cancer originates from a rare sub-population of cells,
namely prostate cancer stem cells (CSCs). Conventional therapies for prostate
cancer are believed to mainly target the majority of differentiated tumor cells
but spare CSCs, which may account for the subsequent disease relapse after
treatment. Therefore, successful elimination of CSCs may be an effective
strategy to achieve complete remission from this disease. Gamma-tocotrienols
(gamma-T3) is one of the vitamin-E constituents which have been shown to have
anticancer effects against a wide-range of human cancers. Recently, we have
reported that gamma-T3 treatment not only inhibits prostate cancer cell invasion
but also sensitizes the cells to docetaxel-induced apoptosis, suggesting that
gamma-T3 may be an effective therapeutic agent against advanced stage prostate
cancer. Here, we demonstrate for the first time that gamma-T3 can down-regulate
the expression of prostate CSC markers (CD133/CD44) in androgen independent (AI)
prostate cancer cell lines (PC-3 & DU145), as evident from western blotting
analysis. Meanwhile, the spheroid formation ability of the prostate cancer cells
was significantly hampered by gamma-T3 treatment. In addition, pre-treatment of
PC-3 cells with gamma-T3 was found to suppress tumor initiation ability of the
cells. More importantly, while CD133-enriched PC-3 cells were highly resistant
to docetaxel treatment, these cells were as sensitive to gamma-T3 treatment as
the CD133-depleted population. Our data suggest that gamma-T3 may be an
effective agent in targeting prostate CSCs, which may account for its anticancer
and chemosensitizing effects reported in previous studies" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.
-
Gamma
Tocopherol Upregulates the Expression of 15-S-HETE and Induces Growth Arrest
Through a PPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells
- Nutr Cancer. 2009;61(5):649-62 - "These data
demonstrate that the growth arrest mediated by gamma-tocopherol follows a
PPAR-gamma-dependent mechanism" - See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
delta-Tocotrienol Suppresses VEGF Induced Angiogenesis whereas alpha-Tocopherol
Does Not - J Agric Food Chem. 2009 Aug 25 -
"Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained
considerable attention as a potent antiangiogenic agent. However, the
majority of vitamin E research has focused on tocopherol (Toc) ... We showed
delta-T3 (2.5-5 muM) completely abolished proliferation, migration and tube
formation of human umbilical vein endothelial cells (HUVECs), whereas a
similar dose of alpha-Toc had no such effects. delta-T3 suppressed VEGF
receptor 2 (VEGFR-2) signaling, and activated caspases in HUVECs. In
addition, via an in vivo mouse Matrigel plug angiogenesis assay, we found
that delta-T3 (30 mug), but not alpha-Toc, inhibited tumor cell-induced
vessel formation. In summary, our results demonstrate delta-T3 has superior
antiangiogenic activities to alpha-Toc, and provide insights into the
different mechanisms responsible for this effect of T3 and Toc" - See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Antioxidant vitamins and the risk of endometrial cancer: a dose-response
meta-analysis - Cancer Causes Control. 2009 Jul;20(5):699-711 -
"Based on case-control data, the random-effects
summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98)
per 1,000 mcg/1,000 kcal (I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI:
0.73-0.98) per 50 mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E:
0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
-
Multivitamin use and telomere length in women - Am J Clin Nutr. 2009
Jun;89(6):1857-63 - "After age and other potential
confounders were adjusted for, multivitamin use was associated with longer
telomeres. Compared with nonusers, the relative telomere length of leukocyte
DNA was on average 5.1% longer among daily multivitamin users (P for trend =
0.002). In the analysis of micronutrients, higher intakes of vitamins C and
E from foods were each associated with longer telomeres, even after
adjustment for multivitamin use. Furthermore, intakes of both nutrients were
associated with telomere length among women who did not take multivitamins"
-
Specific accumulation of gamma- and delta-tocotrienols in tumor and their
antitumor effect in vivo - J Nutr Biochem. 2008 Sep 26 -
"In C3H/HeN mice implanted with MH134, it was found
that gamma-T3 and delta-T3 feeding significantly delayed tumor growth ...
Intriguingly, we found that T3 was detected in tumor, but not in normal
tissues. These results, to our knowledge, are the first demonstration of
specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3
accumulation is critical for the antitumor activities of T3" - See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
The
response of gamma vitamin E to varying dosages of alpha vitamin E plus
vitamin C - Metabolism. 2009 Apr;58(4):469-78 -
"vitamin E has several isomers, with the alpha form being available via
dietary supplements and the gamma form being available via dietary
foodstuffs. The gamma form of vitamin E demonstrates several superior
properties (such as trapping reactive nitrogen species and detoxifying
nitrogen dioxide) compared with alpha vitamin E. All clinical trials have
used the alpha isomer, with little concern that this isomer of vitamin E may
actually suppress the gamma isomer of vitamin E ... The results demonstrate
that alpha vitamin E levels increased in proportion to the dose
administered. However, at every dose of alpha vitamin E, gamma vitamin E
concentration was significantly suppressed ... Our results suggest that all
prospective cardiovascular clinical trials that used vitamin E
supplementation actually suppressed the beneficial antioxidant gamma isomer
of vitamin E" - Dah!! I've been saying that for years.
They're finally catching on. See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
gamma-Tocopherol-enriched mixed tocopherol diet inhibits prostate
carcinogenesis in TRAMP mice - Int J Cancer. 2008 Oct 27 -
"8 week old TRAMP males were fed 0.1%
gamma-T-enriched mixed tocopherol diet that contained 20-fold higher levels
of gamma-tocopherol, and roughly 3-fold higher levels of alpha-tocopherol
... Treatment with gamma-T-enriched mixed tocopherols significantly
suppressed the incidence of palpable tumor and Prostate Intraepithelial
Neoplasia (PIN) development without affecting the expression of the
transgene (SV-40) ... gamma-T-enriched mixed tocopherols significantly
up-regulated the expression of Nrf2 and its related detoxifying and
antioxidant enzymes thereby suppressing PIN and tumor development" -
Note: One previous study was done with alpha-tocopherol. I
cannot understand why they did that when the previous research also
supported the gamma unless they didn't do any homework at all before
planning the study. See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
The
effect of vitamin E on the treatment of menstrual migraine - Med Sci
Monit. 2009 Jan;15(1):CR16-19 - "Vitamin E is
effective in relieving symptoms due to menstrual migraine"
-
Effect
of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal
adenocarcinoma formation in a rat surgical model - Int J Cancer. 2008
Oct 20 - "oxidative stress subsequent to
gastroesophageal reflux is an important driving force of esophageal
adenocarcinoma (EAC) formation in the esophagogastroduodenal anastomosis
(EGDA) rat model. This study investigated the possible tumor inhibitory
effects of 2 antioxidants, alpha-tocopherol (389 and 778 ppm), N-acetylcysteine
(NAC, 500 and 1,000 ppm), and their combination (389 and 500 ppm,
respectively), as well as an antacid therapeutic agent, omeprazole (1,400
ppm) ... alpha-Tocopherol dose-dependently decreased the incidence of EAC (p
= 0.03), with 778 ppm alpha-tocopherol reducing the incidence of EAC to 59%
(16/27) in comparison with 84% (26/31) in the control group (p = 0.04).
Supplementation of alpha-tocopherol also increased the serum concentration
of alpha-tocopherol. NAC at 500 and 1,000 ppm did not significantly decrease
EAC incidence; however, the combination of alpha-tocopherol 389 ppm and NAC
500 ppm significantly reduced the incidence of EAC to 55% (15/27) (p =
0.02). alpha-Tocopherol alone or in combination with NAC significantly
reduced the number of infiltrating cells positively stained for
4-hydroxynonenal. Omeprazole showed only a slight nonsignificant inhibitory
effect at the dose given"
-
Efficacy
of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease:
A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension -
Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We
examined the efficacy of a vitamin/nutriceutical formulation (folate,
vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and
acetyl-L-carnitine) in a 12-month, open-label trial with 14
community-dwelling individuals with early-stage Alzheimer's disease.
Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox
1 and 2). Family caregivers reported improvement in multiple domains of the
Neuropsychiatric Inventory (NPI) and maintenance of performance in the
Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL).
Sustained performance was reported by caregivers for those participants who
continued in an 16-month extension. Performance on the NPI was equivalent to
published findings at 3 to 6 months for donepezil and exceeded that of
galantamine and their historical placebos. Participants demonstrated
superior performance for more than 12 months in NPI and ADL versus those
receiving naproxen and rofecoxib or their placebo group. This formulation
holds promise for treatment of early-stage Alzheimer's disease prior to
and/or as a supplement for pharmacological approaches"
-
Antioxidant treatment
with alpha-tocopherol improves erectile function in hypertensive rats -
Hypertens Res. 2008 May;31(5):1007-13 - "Treatment
with 24 mg alpha-tocopherol decreased TBARS levels and increased SOD
activity in the serum and corpus cavernosum. Relaxation in response to
acetylcholine chloride in the corpus cavernosum was improved with
alpha-tocopherol treatment at each dose. These results suggest that
alpha-tocopherol treatment increases the diminished relaxation in the corpus
cavernosum of SHRs by improving neuronal or endothelial function related to
nitric oxide and carbon monoxide. This, in turn, indicates that antioxidant
therapy may play a role in treatment for ED in hypertensive patients"
-
Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk
- Int J Cancer. 2008 Jun 10 - "When we entered the
other tocopherols in our model, only the association with dietary
alpha-tocopherol intake remained significant; i.e., increasing intake of
dietary alpha-tocopherol accounted for 34-53% reductions in lung cancer
risk"
-
alpha- and gamma-Tocopherol prevent age-related transcriptional alterations
in the heart and brain of mice - J Nutr. 2008 Jun;138(6):1010-8 -
"In the heart, both tocopherol-supplemented diets
were effective in inhibiting the expression of genes previously associated
with cardiomyocyte hypertrophy and increased innate immunity. In the brain,
induction of genes encoding ribosomal proteins and proteins involved in ATP
biosynthesis was observed with aging and was markedly prevented by the
mixture of alphaT and gammaT supplementation but not by alphaT alone. These
results demonstrate that middle age-onset dietary supplementation with
alphaT and gammaT can partially prevent age-associated transcriptional
changes and that these effects are tissue and tocopherol specific"
-
Dietary carotenoids, vitamins C and e, and risk of cataract in women: a
prospective study - Arch Ophthalmol. 2008 Jan;126(1):102-9 -
"In these prospective observational data from a
large cohort of female health professionals, higher dietary intakes of
lutein/zeaxanthin and vitamin E from food and supplements were associated
with significantly decreased risks of cataract"
-
Alpha-tocopherol supplementation prevents the exercise-induced reduction of
serum paraoxonase 1/arylesterase activities in healthy individuals - Eur
J Clin Nutr. 2007 Sep 19 - "Alpha-T supplementation
may result in protection of the enzyme PON 1/Aryl activities from free
radical production"
-
Reduction of DNA damage in older healthy adults by Tri E((R)) Tocotrienol
supplementation - Nutrition. 2007 Sep 19 - "Tri
E((R)) Tocotrienol supplementation may be beneficial by reducing DNA damage
as indicated by a reduction in DNA damage, SCE frequency, and urinary
8-OHdG" - See my favorite
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.
-
Alpha-tocopherol supplementation prevents the exercise-induced reduction of
serum paraoxonase 1/arylesterase activities in healthy individuals - Eur
J Clin Nutr. 2007 Sep 19 - "Alpha-T supplementation
may result in protection of the enzyme PON 1/Aryl activities from free
radical production"
-
Vitamin E dietary supplementation significantly affects multiple risk
factors for cardiovascular disease in baboons - Am J Clin Nutr. 2007
Sep;86(3):597-603 - "vitamin E caused 2 paradoxical
effects on HDL metabolism: higher apolipoprotein A-I (apo A-I)
concentrations and lower HDL sizes ... They also show 2 apparently
paradoxical effects on HDL metabolism: lower HDL(2), which is mediated by
genes, and higher apo A-I, which is not. These effects have contrasting
associations with CVD risk and may help account for the mixed results from
clinical trials of dietary vitamin E"
-
Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis
patients - J Ren Nutr. 2007 Sep;17(5):296-304 -
"gamma tocopherol (308 mg) and DHA (800 mg) ... In the treatment group, but
not in the placebo group, there were significant decreases in IL-6 (21.4 +/-
3.5 to 16.8 +/- 3.7 pg/mL), white blood cell (WBC) count (7.4 +/- 0.3 to 6.9
+/- 0.4 10(3)/microL), and neutrophil fraction of WBCs (4.8 +/- 0.3 to 4.4
+/- 0.3 10(3)/microL), at P < .05 for all"
-
Supplemental and dietary vitamin e intakes and risk of prostate cancer in a
large prospective study - Cancer Epidemiol Biomarkers Prev. 2007
Jun;16(6):1128-35 - "dietary
gamma-tocopherol, the most commonly consumed form of vitamin E in the United
States, was significantly inversely related to the risk of advanced prostate
cancer (for highest versus lowest quintile: RR, 0.68"
-
Supplementation with vitamins C and e improves arterial stiffness and
endothelial function in essential hypertensive patients - Am J
Hypertens. 2007 Apr;20(4):392-7 -
"Combined treatment with vitamins C and E has beneficial effects on
endothelium-dependent vasodilation and arterial stiffness in untreated,
essential hypertensive patients"
-
Effect of the main dietary antioxidants (carotenoids, gamma-tocopherol,
polyphenols, and vitamin C) on alpha-tocopherol absorption - Eur J Clin
Nutr. 2007 Jan 31 - "Naringenin,
carotenoids and probably gamma-tocopherol can impair alpha-tocopherol
absorption whereas vitamin C and phenolic acids have no effect"
-
The effect of vitamin E on blood pressure in individuals with type 2
diabetes: a randomized, double-blind, placebo-controlled trial - J
Hypertens. 2007 Jan;25(1):227-34 -
"Treatment with alpha-tocopherol significantly increased systolic BP [7.0
(5.2, 8.8) mmHg, P < 0.0001], diastolic BP [5.3 (4.0, 6.5) mmHg, P <
0.0001], pulse pressure [1.8 (0.6, 3.0) mmHg, P < 0.005] and heart rate [2.0
(0.6, 3.3) bpm, P < 0.005] versus placebo. Treatment with mixed tocopherols
significantly increased systolic BP [6.8 (4.9, 8.6) mmHg, P < 0.0001],
diastolic BP [3.6 (2.3, 4.9) mmHg, P < 0.0001], pulse pressure [3.2 (2.0,
4.4) mmHg, P < 0.0001] and heart rate [1.8 (0.5, 3.2) bpm, P < 0.01] versus
placebo"
-
Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C
Human Prostate Cancer Cells in Nude Mice
- J Nutr. 2006 May;136(5):1287-93 -
"lycopene combined with vitamin E may inhibit the growth of prostate cancer"
-
Supplementation with mixed tocopherols increases serum and
blood cell {gamma}-tocopherol but does not alter biomarkers of platelet
activation in subjects with type 2 diabetes - Am J
Clin Nutr. 2006 Jan;83(1):95-102 - "Supplementation with
alpha-tocopherol decreased red blood cell gamma-tocopherol, whereas mixed
tocopherols increased both serum alpha-tocopherol and serum and cellular
gamma-tocopherol"
-
Vitamin E Supplementation in Alzheimer's Disease, Parkinson's
Disease, Tardive Dyskinesia, and Cataract: Part 2 (December)
- Ann Pharmacother. 2005 Nov 15 - "We encourage
patients to supplement with vitamin E-rich foods. The use of a daily
multivitamin, which usually contains 30 IU of alpha-tocopherol, may be
beneficial; however, we discourage individual vitamin E supplements that
usually contain 400 IU of alpha-tocopherol"
-
The therapeutic impacts of tocotrienols in type 2 diabetic patients with
hyperlipidemia - Atherosclerosis. 2005 Oct;182(2):367-74 -
"tocotrienol rich fraction (TRF) ...
After 60 days of TRF treatment, subjects showed an average decline of 23,
30, and 42% in serum total lipids, TC, and LDL-C, respectively ... daily
intake of dietary TRF by type 2 diabetics will be useful in the prevention
and treatment of hyperlipidemia and atherogenesis"
-
Vitamin E at high doses improves survival, neurological performance and
brain mitochondrial function in aging male mice - Am J Physiol Regul
Integr Comp Physiol. 2005 Jul 14 -
"Male mice receiving vitamin E (5.0 g alpha-tocopherol acetate/kg of food)
from 28 wk of age showed a 40 % increased median lifespan ... and 17 %
increased maximal lifespan, whereas female mice equally supplemented
exhibited only 14 % increased median lifespan ... Vitamin E-supplemented
male mice showed a better performance in the tightrope (neuromuscular
function) and the T-maze (exploratory activity) tests" - [eurekalert.org]
-
Vitamin E in the primary prevention of cardiovascular disease and cancer:
the Women's Health Study: a randomized controlled trial - JAMA. 2005 Jul
6;294(1):56-65
-
The effect of gamma-tocopherol administration on alpha-tocopherol levels and
metabolism in humans - Eur J Clin Nutr. 2005 Jun 1 -
"The plasma alpha-tocopherol
concentration decreased significantly during gamma-tocopherol
administration"
-
Vitamins E and C are safe across a broad range of intakes - Am J Clin
Nutr. 2005 Apr;81(4):736-45 -
"vitamin E supplements appear safe for most adults in amounts </=1600 IU
(1073 mg RRR-alpha-tocopherol or the molar equivalent of its esters) and
that vitamin C supplements of </=2000 mg/d are safe for most adults"
-
A randomized trial of antioxidant vitamins to prevent second primary cancers
in head and neck cancer patients - J Natl Cancer Inst. 2005 Apr
6;97(7):481-8 - "alpha-Tocopherol
supplementation produced unexpected adverse effects on the occurrence of
second primary cancers and on cancer-free survival"
-
Effects of long-term vitamin E supplementation on cardiovascular events and
cancer: a randomized controlled trial - JAMA. 2005 Mar
16;293(11):1338-47
-
Dietary intake of vitamin C and vitamin E and the development of
hypertensive disorders of pregnancy - Eur J Obstet Gynecol Reprod Biol.
2005 Mar 1;119(1):67-71 - "Low
vitamin E intake was associated with a significant increase in the risk of
hypertensive disorders of pregnancy"
-
Vitamin E and respiratory tract infections in elderly nursing
home residents: a randomized controlled trial -
JAMA. 2004 Aug 18;292(7):828-36
- Supplementation of Diets with alpha-Tocopherol Reduces Serum Concentrations
of gamma- and delta-Tocopherol in Humans - J Nutr.
2003 Oct;133(10):3137-40 -
"Despite promising evidence from in
vitro experiments and observational studies, supplementation of diets with
alpha-tocopherol has not reduced the risk of cardiovascular disease and
cancer in most large-scale clinical trials. One plausible explanation is
that the potential health benefits of alpha-tocopherol supplements are
offset by deleterious changes in the bioavailability and/or bioactivity of
other nutrients ... Compared with placebo, supplementation with
alpha-tocopherol reduced serum gamma-tocopherol concentrations by a median
change of 58% ... and reduced the number of individuals with detectable
delta-tocopherol concentrations ... In view of the potential benefits of
gamma- and delta-tocopherol, the efficacy of alpha-tocopherol
supplementation may be reduced due to decreases in serum gamma- and
delta-tocopherol levels. Additional research is clearly warranted" -
This is what I've been saying for years yet they still do nearly all the
studies with the alpha-tocopherol.
- Vitamin E supplementation increases LDL resistance to ex vivo oxidation in
hemodialysis patients - "Int J Vitam Nutr Res.
2003 Jul;73(4):290-6 -
"Since oral vitamin E supplementation
prevents oxidative stress and significantly increases LDL resistance to ex
vivo oxidation, supplementation by natural antioxidants such as vitamin E
may be beneficial in hemodialysis
patients"
- Oral Antioxidant Therapy Improves Endothelial Function in Type 1 but not
Type 2 Diabetes Mellitus - Am J Physiol Heart Circ
Physiol. 2003 Dec;285(6):H2392-8. Epub 2003 Jul 24 -
"subjects were randomized to oral vitamin C 1000 mg and vitamin E 800 IU
daily or matching placebo for six months ... Oral antioxidant therapy
improves EDV
in T1 but not T2 diabetes" - The measurement of Vitamin E in IUs
shows that they are still using d-alpha-tocopherol or worse, the
dl-alpha-tocopherol instead of mixed tocopherols including the tocotrienols
in studies. Just for starters, the d-alpha lowers gamma.
- Gamma-Tocopherol, the new vitamin E? - AJCN,
3/1/03
- Non-nutritive bioactive food constituents of plants: tocopherols (vitamin E)
- Int J Vitam Nutr Res 2003 Mar;73(2):89-94 -
"in food, gamma- and delta-tocopherol
are a more potent antioxidant than alpha-tocopherol. Tocopherols as a group
are the key antioxidants in human cell membranes and are also important in
protecting the LDL particles"
- Vitamin E prevents changes in the cornea and conjunctiva due to vitamin A
deficiency - Graefes Arch Clin Exp Ophthalmol 2003
Apr;241(4):287-97 -
"The present study suggests that
vitamin E has a protective effect against the corneal and conjunctival
damage caused by vitamin A deficiency"
-
High-dose antioxidant supplements and cognitive function in
community-dwelling elderly women - Am. J. of Clin. Nutr., 4/03 -
"Long-term, current users of vitamin E with
vitamin C had significantly better mean performance, as judged by a
global score that combined individual test scores, than did women who had
never used vitamin E or C (P = 0.03); there was a trend for increasingly
higher mean scores with increasing durations of use (P = 0.04). These
associations were strongest among women with low dietary intakes of
alpha-tocopherol. Benefits were less consistent for women taking vitamin E
alone, with no evidence of higher scores with longer durations of use. Use
of specific vitamin C supplements alone had little relation to performance
on our cognitive tests"
-
Mixed tocopherols inhibit platelet aggregation in humans: potential
mechanisms - AJCN, 3/1/03 -
"ADP-induced platelet aggregation decreased significantly in the mixed
tocopherol group but not in the alpha-tocopherol and control groups ...
Effects of mixed tocopherols were associated with increased NO release, ecNOS
activation, and SOD protein content in platelets, which may contribute to
the effect on platelet aggregation"
-
Antioxidants and Risk of Alzheimer Disease - JAMA, 11/13/02 -
"Dr Morris and colleagues1 and Dr Engelhart and colleagues2 found an inverse
relationship between intake of vitamin E from food, but not from
supplements, with risk of Alzheimer disease (AD).3 I would like to
suggest a mechanism for this finding. The predominant dietary form of
vitamin E, gamma-tocopherol, but not the form found in supplements,
alpha-tocopherol, has been demonstrated to inhibit cyclooxygenase 2 (COX-2)
production of prostaglandin E2
in macrophages and epithelial cells"
- Association between alpha-tocopherol, gamma-tocopherol, selenium, and
subsequent prostate cancer - J Natl Cancer Inst.
2000 Dec 20;92(24):2018-23 -
"For gamma-tocopherol, men in the
highest fifth of the distribution had a fivefold reduction in the risk of
developing prostate cancer than men in the lowest fifth" - [Full
Article]
-
Effect of oral supplementation with D-alpha-tocopherol on the vitamin E
content of human low density lipoproteins and resistance to oxidation -
J Lipid Res. 1991 Aug;32(8):1325-32 -
"gamma-Tocopherol significantly
decreased in plasma and LDL during vitamin E (alpha-tocopherol)
supplementation"
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