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Home > Health Conditions > Cancer Cures?

Cancer Cures?

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  • Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence - EBioMedicine 2023 Mar 10 - "Glioblastoma is one of the most devastating and incurable cancers due to its aggressive behaviour and lack of available therapies, being its overall-survival from diagnosis ∼14-months. Thus, identification of new therapeutic tools is urgently needed. Interestingly, metabolism-related drugs (e.g., metformin/statins) are emerging as efficient antitumour agents for several cancers ... Altogether, metformin and simvastatin reduce aggressiveness features in glioblastomas, being this effect significantly more effective (in vitro/in vivo) when both drugs are combined, offering a clinically relevant opportunity that should be tested for their use in humans" - See metformin at ReliableRX and simvastatin at ReliableRXPharmacy.
  • Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets - Phytother Res 2023 Mar 8 - "Natural plant phytochemicals are effective against different types of diseases, including cancer. Curcumin, a powerful herbal polyphenol, exerts inhibitory effects on cancer cell proliferation, angiogenesis, invasion, and metastasis through interaction with different molecular targets. However, the clinical use of curcumin is limited due to poor solubility in water and metabolism in the liver and intestine. The synergistic effects of curcumin with some phytochemicals such as resveratrol, quercetin, epigallocatechin-3-gallate, and piperine can improve its clinical efficacy in cancer treatment. The present review specifically focuses on anticancer mechanisms related to the co-administration of curcumin with other phytochemicals, including resveratrol, quercetin, epigallocatechin-3-gallate, and piperine. According to the molecular evidence, the phytochemical combinations exert synergistic effects on suppressing cell proliferation, reducing cellular invasion, and inducing apoptosis and cell cycle arrest" - See curcumin at Amazon.com.
  • Ultra-processed foods may increase ovarian, other cancer risks, study says - Washington Post, 2/1/23 - "Many foods go through a moderate amount of processing — such as cheese, salted peanut butter, pasta sauce — but ultra-processed foods have more additives, artificial flavors, colors, sweeteners and preservatives. Typically they are subjected to processing methods to transform their taste, texture and appearance and can include hot dogs, doughnuts, boxed macaroni & cheese, muffins and flavored yogurts ... higher consumption of ultra-processed foods is associated with a greater risk of overall cancer and specifically ovarian and brain cancer ... For every 10 percent increase in ultra-processed food in a person’s diet, there was an increased incidence of 2 percent for cancer overall, and a 19 percent increase for ovarian cancer specifically ... Other studies have shown a link between ultra-processed foods and higher rates of obesity, hypertension, type 2 diabetes and colon cancer"
  • Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis - Nutr Cancer 2023 Jan 30 - "The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention ... Overall, chondroitin and/or glucosamine intake was associated with a lower risk of colorectal cancer (OR = 0.91, 95% CI, 0.87-0.94) and lung cancer (OR = 0.84"  - See glucosamine chondroitin formulas at Amazon.com.
  • The Therapeutic Alliance between Pomegranate and Health Emphasizing on Anticancer Properties - Antioxidants (Basel) 2023 Jan 12 - "Pomegranate is a fruit bearing-plant that is well known for its medicinal properties. Pomegranate is a good source of phenolic acids, tannins, and flavonoids. Pomegranate juice and by-products have attracted the scientific interest due to their potential health benefits. Currently, the medical community has showed great interest in exploiting pomegranate potential as a protective agent against several human diseases including cancer. This is demonstrated by the fact that there are more than 800 reports in the literature reporting pomegranate's anticancer properties" - See pomegranate extract at Amazon.com.
  • Resveratrol induces DNA damage-mediated cancer cell senescence through the DLC1-DYRK1A-EGFR axis - Food Funct 2023 Jan 18 - "Inducing cell senescence is widely regarded as a potent tumor suppression mechanism. Resveratrol has attracted increasing attention for its capacity to prevent and suppress cancer. However, the mechanism of resveratrol on the induction of cancer cell senescence has not been well clarified. Our results showed that resveratrol inhibited cell viability and colony formation and promoted cell senescence along with augmentation of SA-β-gal activity and modulation of senescence-associated molecular markers p53, p21 and LaminB protein in breast and liver cancer cells ... This is the first report to investigate whether resveratrol induces DNA damage-mediated cancer cell senescence through the DLC1-DYRK1A-EGFR axis, which could provide a solid base for resveratrol's application in cancer prevention and clinical treatment as a food additive or adjuvant therapies." - See resveratrol products at Amazon.com.
  • The phenolic components extracted from mulberry fruits as bioactive compounds against cancer: A review - Phytother Res 2023 Jan 2 - "There is growing evidence that mulberry fruits can potentially prevent cancer and other aging-related disorders due to their high concentration of bioactive polyphenolic-rich compounds and macro and micronutrients" - See mulberry leaf extract at Amazon.com.
  • Few Americans aware of cancer risks posed by alcohol: study - Hill, 12/2/22 - "All types of alcoholic beverages, including wine, increase cancer risk ... Studies have shown a link between alcohol intake and cancers of the mouth, throat, voicebox, esophagus, liver, colon and rectum, and breast ... The risks are especially elevated for breast cancer."
  • α-ketoglutarate suppresses immediate early gene expression in cancer cells - Biochem Biophys Res Commun 2022 Nov 11 - "Cancer cells exhibit increased glutamine consumption compared to normal cells, supporting cell survival and proliferation. Glutamine is converted to α-ketoglutarate (αKG), which then enters the tricarboxylic acid cycle to generate ATP. Recently, therapeutic modulation of glutamine metabolism has become an attractive metabolic anti-cancer strategy ... Together, these findings indicate that therapeutic targeting of IEG dysregulation by αKG can be a potentially effective anti-cancer therapeutic strategy for glutamine metabolism inhibitors" - See alpha ketoglutarate at Amazon.com.
  • Anti-diabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1 - J Biol Chem 2022 Nov 7 - "Metformin, an antidiabetic drug, shows some potent anti-tumor effects. However, the molecular mechanism of metformin in tumor suppression has not been clarified. Here we provided evidence using in vitro and in vivo data that metformin inhibited mevalonate pathway by downregulation of HMGCS1, a key enzyme in this pathway. Our results further demonstrated that metformin downregulated HMGCS1 expression through inhibition of transcription factor NRF2. Additionally, we determined that HMGCS1 was highly expressed in human liver and lung cancer tissues and associated with lower survival rates. In summary, our study indicated that metformin suppresses tumorigenesis through inhibition of the NRF2/HMGCS1 axis, which might be a potential target in cancer prevention and treatment." - See metformin at ReliableRX.
  • Metformin, Testosterone Replacement Linked to Reduced Cancer Risk - Medscape, 8/26/22 - "metformin and testosterone replacement therapy were independently and jointly associated with a reduced incidence of prostate cancer, with the greatest reduction with the combination of the two (joint odds ratio [OR],  0.44) ... The two drugs were also inversely associated with a high grade at prostate cancer diagnosis (joint OR, 0.36) and advanced cancer stage (joint OR, 0.47), after multivariate adjustment for factors including age, race/ethnicity, hypogonadism, hypertension, diabetes, insulin use, muscular wasting, and other factors ... Metformin and testosterone replacement therapy were also independently and in combination inversely associated with the incidence of colorectal cancers (joint OR, 0.47); however, the associations with higher grade and advanced stage were not consistent, the authors note" - Note: Good luck with that. Testosterone prescriptions are another one that's like getting a prescription for cocaine. Doctors seem locked in a previous era. See metformin at ReliableRX..
  • Complexity of Tumor Microenvironment: Therapeutic Role of Curcumin and Its Metabolites - Nutr Cancer 2022 Jul 11 - "The tumor microenvironment (TME) is a complex network of cellular and non-cellular components surrounding the tumor ... Curcumin and its metabolites regulate TME by inhibiting the growth of its cellular components such as cancer-associated adipocytes, cancer-associated fibroblast, tumor endothelial cells, tumor-stimulating immune cells, and inducing anticancer immune cells. They also inhibit the interplay of tumor cells to TME by suppressing non-cellular components such as extracellular matrix, and associated tumor promoting signaling-pathways. In addition, curcumin inhibits the inflammatory environment, suppresses angiogenic factors, and increases antioxidant status in TME. Overall, curcumin has the capability to regulate TME components and their interaction with tumor cells" - See curcumin at Amazon.com.
  • Preclinical studies of the antitumor effect of curcumin-loaded polymeric nanocapsules: A systematic review and meta-analysis - Phytother Res 2022 Jul 1 - "Curcumin, a plant-derived compound, has various well-known biological effects (anti-inflammatory, antioxidant, antitumor, among others) as well as some important limitations for formulators, such as poor water solubility and low oral bioavailability. Its nanoencapsulation is reported to overcome these drawbacks and to improve its in vivo efficacy. Here, data from preclinical in vivo studies evaluating the antitumor efficacy of curcumin-loaded polymeric nanocapsules are collected, analyzed, and discussed as a systematic review ... The evidence that curcumin-loaded polymeric nanocapsules inhibits tumor growth (SMD: -3.03; 95% CI: -3.84, -2.21; p < 0.00001) and decreases tumor weight (SMD: -3.96; 95% CI: -6.22, -1.70; p = 0.0006) in rodents is established, regardless of the solid tumor model. To assess the quality of the studies included in the review a bias risk analysis was performed using the SYRCLE's RoB tool. Therefore, encapsulation in polymeric nanocapsules represents an important tool to improve the antitumor effects of curcumin, and this systematic review paves the way for future clinical studies and the translation of curcumin formulations into novel nanomedicines for human cancer treatment" - See nano encapsulation curcumin at Amazon.com.
  • Consumption of flavonoids and risk of hormone-related cancers: a systematic review and meta-analysis of observational studies - Nutr J 2022 May 11 - "The present study suggests evidence that intake of total flavonoids, flavonols, flavones, flavanones, flavan-3-ols and isoflavones would be associated with a lower or higher risk of HRCs, which perhaps provides guidance for diet guidelines to a certain extent" - See blueberry extract at Amazon.com.
  • New study reviews anti-cancer activity of sustained release capsaicin formulations - Science Daily, 5/4/22 - "The nutritional agent capsaicin displayed robust growth-inhibitory activity in a diverse array of human cancers. However, the clinical applications of capsaicin as a viable anti-cancer agent were hindered by three factors -- poor solubility, low bioavailability and spicy flavor ... Oral use of capsaicin is associated with unfavorable side effects such as stomach cramps, nausea, a burning sensation in the gut and gastrointestinal irritation ... A strategy to overcome these drawbacks is the development of different delivery systems, such as encapsulating capsaicin in long-acting sustained release drug delivery systems could allow for more consistent capsaicin levels that could be more efficient as anti-cancer agents" - See capsicum at Amazon.com.
  • Vitamin E can boost immunotherapy responses by reinvigorating dendritic cells - Science Daily, 4/14/22 - "Patients with melanoma who took vitamin E while on anti-PD-1/PD-L1 checkpoint inhibitors had significantly improved survival compared to patients who didn't take vitamin E or multivitamins. This finding was replicated in an independent mixed cohort of patients with breast, colon and kidney cancers. However, patients taking vitamin E while being treated with chemotherapy did not experience the same benefits, suggesting the effects were unique to chemotherapy" - See vitamin E at Amazon.com.
  • Cruciferous vegetable consumption and multiple health outcomes: an umbrella review of 41 systematic reviews and meta-analyses of 303 observational studies - Food Funct 2022 Mar 30 - "Of the 41 meta-analyses, we observed suggestive evidence for beneficial associations between gastric cancer, lung cancer, endometrial cancer, and all-cause mortality. Moreover, 16 associations were supported by weak evidence, including breast cancer, lung cancer, renal cell carcinoma, bladder cancer, prostate cancer, ovarian cancer, endometrial cancer, colon cancer, colorectal adenoma, colorectal neoplasm, non-Hodgkin lymphoma, and total cancer" - See cruciferous vegetables supplements at Amazon.com.
  • Study suggests association between consuming artificial sweeteners and increased cancer risk - Science Daily, 3/24/22 - "enrollees consuming larger quantities of artificial sweeteners, particularly aspartame and acesulfame-K, had higher risk of overall cancer compared to non-consumers (hazard ratio 1.13, 95% confidence interval 1.03 to 1.25). Higher risks were observed for breast cancer and obesity-related cancers"
  • Omega-3 Polyunsaturated Fatty Acids can Reduce IL-6 and TNF Levels in Patients with Cancer - Br J Nutr 2022 Mar 7 - "Omega-3 PUFAs can reduce circulating IL-6 and TNF levels in patients with cancer. Results supported the recommendation of omega-3 PUFAs as adjuvant therapy for patients with cancer, possibly excluding head and neck cancer, owing to their anti-inflammatory properties" - See omega-3 supplements at Amazon.com.
  • Magnesium is essential for the immune system, including in the fight against cancer - Science Daily, 1/19/22 - "Magnesium deficiency is associated with a variety of diseases, such as infections and cancer. Previous studies have shown that cancerous growths spread faster in the bodies of mice when the animals received a low-magnesium diet -- and that their defense against flu viruses was also impaired ... T cells can eliminate abnormal or infected cells efficiently only in a magnesium-rich environment. Specifically, magnesium is important for the function of a T cell surface protein called LFA-1 ... The fact that magnesium is essential for the functioning of T cells may be a highly significant finding for modern cancer immunotherapies. These therapies aim to mobilize the immune system -- in particular cytotoxic T cells -- to fight cancer cells. In experimental models, the researchers were able to show that the immune response of T cells against cancer cells was strengthened by an increase in the local magnesium concentration in tumors" - See magnesium supplements at Amazon.com.
  • Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of TP73 - Food Funct 2021 Dec 13 - "Maritime pine bark is a rich source of polyphenolic compounds and is commonly employed as a herbal supplement worldwide. This study was designed to check the potential of maritime pine tannin extract (MPTE) in anticancer therapy and to determine the underlying mechanism of action. Our results showed that MPTE, containing procyanidin oligomers and lanostane type terpenoids, has an inhibitory effect on cancer cell proliferation through cell cycle arrest in the G2/M phase. Treatment with MPTE also induced apoptosis in a concentration-dependent manner in human cancer cell lines (HeLa and U2OS), as evidenced by the enhanced activation of caspase 3 and the cleavage of PARP along with the downregulation of the antiapoptotic protein ... Overall, our results show that maritime pine tannin extract can play a favorable role in cancer treatment, and can be further explored by the pharmaceutical industry" - See pine bard extract at Amazon.com.
  • Multi-targeted therapy of cancer by omega-3 fatty acids-an update - Cancer Lett 2021 Nov 26 - "Low in dietary ω3 polyunsaturated fatty acid (PUFA) consumption has been associated with increased incidence of cancers. Many basic and clinical studies have been conducted over the last several decades. We previously reviewed multi-targeted therapy of cancer by omega-3 fatty acids in 2008, and since hundreds of new clinical trials are being conducted to validate the effectiveness of ω3 PUFA in cancer therapy. Because of the availability of such large amount of clinical trial data, in this update we summarize clinical data, sort out trials that show promising results, and discuss potential mechanism(s) responsible for the clinical outcomes. It appears that ω3 PUFA mainly affects cancer-associated symptoms, namely cachexia, inflammation, neuropathy, post operative complications and quality of life. Mechanisms responsible for these effects are possible regulation of skeletal muscle protein turnover, inflammatory response and neuron cell survive by ω3 PUFA" - See omega-3 supplements at Amazon.com.
  • Repurposing Natural Dietary Flavonoids in the Modulation of Cancer Tumorigenesis: Decrypting the Molecular Targets of Naringenin, Hesperetin and Myricetin - Nutr Cancer 2021 Nov 5 - "In the past few years flavonoids have been gaining more attention regarding their (still un) exploited anticancer properties. Flavonoids are natural compounds present in fruits, vegetables, and seeds, meaning that they are already present in the daily life of every person, with a described broad-spectrum of pharmacological activities, including anticancer, anti-inflammatory and antioxidant ... Although some mechanisms underlying their activities remain still unclear, they can act as potential inhibitors of key tumorigenic signaling pathways, such as PI3K/Akt/mTOR, p38 MAPK and NF-κB. Simultaneously, they can reset the levels of pro-apoptotic proteins that belong to the Bcl-2 and caspase family and decrease the intracellular levels of ROS and pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6. Together with their synergetic effect they have the potential to become key elements in the prevention and/or treatment of several types of cancer, with the major improvement to the patient life quality, due to their non-existent toxicity" - See flavonoids at Amazon.com.
  • Protein intake and muscle mass maintenance in patients with cancer types with high prevalence of sarcopenia: a systematic review - Support Care Cancer 2021 Oct 25 - "Cancer is associated with muscle wasting. However, optimal protein intake has not been determined, limiting the efficacy of nutritional interventions ... Our findings show that protein intakes below 1.2 g/kg, even when within the recommendations, have been associated with muscle wasting during treatment. Only intakes above 1.4 g/kg have been associated with muscle maintenance. High-quality research is needed to establish an optimal dose response"
  • Cancer is largely preventable, but most people don't know it - Hill, 10/27/21 - "While it's true that some cancers come from inherited mutations or other genetic predispositions, most experts agree that about 70 percent of cancers can be prevented. This could be among the least-known medical facts of our time ... more than half of Americans don't realize that the type of food they eat, as well as the amount of alcohol they drink, play an important role in developing certain cancers ... People also need to know about the relationship between physical inactivity and cancer cell growth — because the science on the subject speaks volumes. Getting in your daily 10,000 steps isn't a bad thing, but it's not enough for cancer prevention. That requires working up a sweat for 20 minutes to half an hour about five days a week. What activity you do — from jogging to biking to vacuuming the house — is less important than ensuring you get to at least a moderate level of intensity. How do you know you're there? Though you may still be able to talk while doing it, you shouldn't have enough extra breath to sing ... It's also time to explain how chronic stress, and the hormones it creates, may decrease immune function — and how to relieve that stress ... don't forget the importance of quality sleep as well as the quantity ... flossing your teeth every day for good dental hygiene, good for you. You're also decreasing your cancer risk, because gum disease has links to cancer"
  • Quercetin and its role in modulating endoplasmic reticulum stress: A review - Phytother Res 2021 Sep 15 - "Quercetin is a plant-derived metabolite belonging to the flavonoids class which presents a range of beneficial effects including anti-inflammatory, cardioprotective, anti-oxidant, anti-obesity, anti-carcinogenic, anti-atherosclerotic, anti-diabetic, anti-hypercholesterolemic, and anti-apoptotic activities. Quercetin also has anti-cancer activity, and can be used as an adjuvant to decrease resistance to cancer chemotherapy. Furthermore, the effect of quercetin can be increased with the help of nanotechnology" - See quercetin at Amazon.com and iHerb.
  • Kaempferol 3-O-gentiobioside, an ALK5 inhibitor, affects the proliferation, migration, and invasion of tumor cells via blockade of the TGF-β/ALK5/Smad signaling pathway - Phytother Res 2021 Sep 12 - "This study provided novel insight into the anticancer effects of KPF-3-O-G and indicated that KPF-3-O-G might be developed as potential therapeutics for cancer treatment after further validation" - See kaempferol at Amazon.com.
  • The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives - Phytother Res 2021 Sep 8 - "Flavonoids constitute one of the most important classes of polyphenols, which have been found to have a wide range of biological activities such as anticancer effects. A large body of evidence demonstrates that morin as a pleiotropic dietary flavonoid possesses potent anticarcinogenic and anticancer activities with minimal toxicity against normal cells. The present review comprehensively elaborates the molecular mechanisms underlying antitumorigenic and anticancer effects of morin. Morin exerts its anticarcinogenic effects through multiple cancer preventive mechanisms, including reduction of oxidative stress, activation of phase II enzymes, induction of apoptosis, attenuation of inflammatory mediators, and downregulation of p-Akt and NF-κB expression. A variety of molecular targets and signaling pathways such as apoptosis, cell cycle, reactive oxygen species (ROS), matrix metalloproteinases (MMPs), epithelial-mesenchymal transition (EMT), and microRNAs (miRNAs) as well as signal transducer and activator of transcription 3 (STAT3), NF-κB, phosphatidylinositol 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), and Hippo pathways have been found to be involved in the anticancer effects of morin" - See flavonoids at Amazon.com and flavonoids at iHerb.com.
  • Rutin: A Flavonoid as an Effective Sensitizer for Anticancer Therapy; Insights into Multifaceted Mechanisms and Applicability for Combination Therapy - Evid Based Complement Alternat Med 2021 Aug 23 - "Rutin is demonstrated to inhibit the proliferation of breast, colon, lung, and prostate cancers and other tumors. Furthermore, rutin alone or in combination with other therapeutic agents has been shown to regulate several signalling pathways involving the Ras/Raf and PI3K/Akt, MAPK, and TGF-β2/Smad2/3Akt/PTEN, etc., which are related to the processes of carcinogenesis and induction of apoptosis. The combination of rutin with other chemotherapy drugs may benefit on prevention of tumor cells by decreasing drug resistance and chemotherapy side effects. Moreover, rutin induces apoptosis synergistically with the therapeutic agent. More in vivo and clinical data are however needed to evaluate the true potential of rutin as an anticancer agent as an adjuvant. The present review highlights the effects of rutin which can be a promising candidate in combination with other antitumor drugs or alone for cancer treatment in vitro. Also, rutin can lead to decrease in drug resistance and chemotherapeutic side effects" - See rutin at Amazon.com and rutin at iHerb.com.
  • Glucosinolate-Enriched Fractions from Maca ( Lepidium meyenii) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines - Nutr Cancer 2021 Jul 20 - "The consumption of glucosinolate (GL)-rich foods, including Brassica vegetables, such as mustard, broccoli, and maca, is associated with decreased risk of developing cancer. The GL content in maca, which is recognized as a "superfood", is approximately 100-times higher than that in other brassicas. Although maca is a potential dietary source of GLs, limited studies have examined the bioactivity of maca GLs using the combination of chemical characterization and bioassays ... These results suggest that the anticancer properties of maca can be attributed to GLs and corroborate the categorization of maca as a "superfood."" - See maca extract at Amazon.com.
  • Statins Linked to Lower Cancer Rate in Heart Failure Patients - Medscape, 6/24/21 - "In this large-population study in heart failure patients, we found a 16% reduction in the incidence of cancer and a 36% reduction in cancer deaths in patients taking statins compared to those not taking statins"
  • Boosting immune system against cancer by resveratrol - Phytother Res 2021 Jun 8 - "Modulation of the immune system is a critical part of anticancer therapies including immunotherapy, chemotherapy, and radiotherapy. The aim of immunomodulation in cancer therapy is boosting immune system cells including CD8+ T lymphocytes and natural killer (NK) cells, as well as suppression of immunosuppressive responses by macrophages and regulatory T cells (Tregs) ... Resveratrol, as a natural agent, has shown ability to modulate the immune system to potentiate antitumor immunity. Resveratrol has been shown to induce the release of anticancer cytokines such as IFN-γ and TNF-α and also inhibits the release of TGF-β. It also can stimulate the polarization of CD4+ T cells and macrophages toward anticancer cells and reduce infiltration and polarization of immunosuppressive cells. Furthermore, resveratrol can sensitize cancer cells to the released dead signals by anticancer immune cells. This review explains how resveratrol can boost the immune system against cancer via modulation of immune cell responses within tumor" - See resveratrol products at Amazon.com.
  • Cross-sectional observational study - Investigation of vitamin D concentration in Caucasian cancer patients. what is the adequate dose of vitamin D for these patients? - Clin Nutr 2021 Apr 22 - "Vitamin D impairs tumour-related transformation and supports the anticancer function of the immune system. Currently, there are no guidelines on vitamin D supplementation devoted solely to cancer patients. The primary objective of the study was to evaluate the frequency of vitamin D deficiency in Caucasian cancer patients and to characterize the clinical factors that predispose individuals to decreased vitamin D concentration. Secondly, the study aimed to estimate the dose of vitamin D supplementation that would prevent deficiencies in patients with cancer ... Vitamin D deficiency was diagnosed in 66.8% of patients with cancer and even in 31.6% who declared vitamin D supplementation. Older age, male gender, diagnosis of head and neck cancer or squamous cell carcinoma and body mass loss were identified as factors that predispose to vitamin D deficiency. The dose of vitamin D that would prevent deficiency in Caucasian patients with cancer was set at 2250 IU daily" - See vitamin D at Amazon.com.
  • An omega-3 that's poison for tumors - Science Daily, 6/11/21 - "So-called "good fatty acids" are essential for human health and much sought after by those who try to eat healthily. Among the Omega-3 fatty acids, DHA or docosahexaenoic acid is crucial to brain function, vision and the regulation of inflammatory phenomena ... In addition to these virtues, DHA is also associated with a reduction in the incidence of cancer ... the team quickly identified that these acidotic tumour cells responded in diametrically opposite ways depending on the fatty acid they were absorbing. Within a few weeks, the results were both impressive and surprising. "We soon found that certain fatty acids stimulated the tumour cells while others killed them," the researchers explained. DHA literally poisons them ... it's recommended to consume at least 250 mg of DHA per day. But studies show that our diet provides on average only 50 to 100 mg per day. This is well below the minimum recommended intake" - See docosahexaenoic acid at Amazon.com.
  • Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha) - Nutr Cancer 2021;73(6):914-926 - "Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, which remains as one of the most dreadful diseases on the globe ... Through this review, we highlight the importance of W. somnifera in countering the potential oncogenic signaling mediators that are modulated by active constituents of W. somnifera in a variety of cancer types" - See Ashwagandha at Amazon.com.v
  • Theanine and cancer: A systematic review of the literature - Phytother Res 2021 Apr 23 - "A growing literature indicates several health benefits of theanine, a major nonprotein derivative amino acid special to tea, and a nonedible mushroom ... Most of the included in vitro and ex vivo studies reported beneficial effects of theanine on the proliferation, apoptosis, metastasis, migration, and invasion in various cancer cell lines. The in vivo studies also supported the potential impacts of theanine on cancer incidence or progression. Theanine exerted its anticancer function by inhibiting EGFR, VEGFR, Met, and Akt/mTOR, JAK2/STAT3, and ERK/NFκB pathways, as well as activating the intrinsic apoptosis pathway and caspase-independent programmed cell death. In conclusion, the results indicated moderate apoptotic, antimetastatic, antimigration, and anti-invasion effects, along with the mild antiproliferative influence of theanine on cancer" - See theanine at Amazon.com.
  • Green tea compound aids p53, 'guardian of the genome' and tumor suppressor - Science Daily, 2/12/21 - "An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells. Published today in Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery" - See epigallocatechin-3-gallate at Amazon.com.
  • Berberine-A potent chemosensitizer and chemoprotector to conventional cancer therapies - Phytother Res 2021 Feb 8 - "Chemotherapy and radiotherapy are mainstay treatments for cancer patients. However, their clinical outcomes are highly limited by the resistance of malignant tumors to these therapies and the incurrence of serious damages in vital organs. This in turn necessitates the development of adjunct drugs that overcomes chemo/radioresistance in refractory cancers and protects vital organs from the cytotoxic effects of cancer therapies. In recent years, Berberine (BBR), a natural isoquinoline alkaloid has garnered more attention due to its potent chemosensitizing and chemoprotective properties. BBR effectively sensitizes refractory cancers to chemotherapy and radiotherapy by ameliorating the diverse events underlying therapy resistance. Furthermore, it protects the heart, liver, lungs, and kidneys from severe damages caused by these therapies. In this review, we discuss the molecular mechanisms underlying the chemo/radiosensitizing and chemo/radioprotective potential of BBR during cancer treatment." - See berberine at Amazon.com.
  • Vitamin D supplementation: Possible gain in life years combined with cost savings - Science Daily, 2/10/21 - "Three meta-analyses of large clinical studies have been published in recent years on the question of how vitamin D supply affects cancer mortality rates. The studies* came to the same conclusion: cancer mortality is reduced by around 13 percent with vitamin D supplementation -- across all cancers. Only methodologically high-quality randomized trials from all parts of the world were included in the meta-analyses. Exactly what biological mechanisms might underlie this is not yet clear" - See vitamin D at Amazon.com.
  • How exercise stalls cancer growth through the immune system - Science Daily, 10/26/20 - "Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth"
  • Statins may reduce cancer risk through mechanisms separate to cholesterol - Science Daily, 10/13/20 - "Taken together, these results suggest that inhibiting HMGCR with statins may help reduce cancer risk though non-lipid lowering mechanisms, and that this role may apply across cancer sites ... This effect may operate through other properties of statins, including dampening down inflammation or reducing other chemicals produced by the same cellular machinery which synthesises cholesterol"
  • Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics - Nutrients 2020 Aug 5 - "Vitamin C (ascorbate) acts as an antioxidant and enzyme cofactor, and plays a vital role in human health. Vitamin C status can be affected by illness, with low levels being associated with disease due to accelerated turnover ... We recruited 150 fasting patients with cancer (of 199 total recruited) from two cohorts, either prior to cancer surgery or during cancer chemo- or immunotherapy. A significant number of patients with cancer had inadequate plasma ascorbate concentrations. Low plasma status was more prevalent in patients undergoing cancer therapy. Ascorbate status was higher in women than in men, and exercising patients had higher levels than sedentary patients. Our study may prompt increased vigilance of ascorbate status in cancer patients" - See vitamin C products at Amazon.com and vitamin C at iHerb.com.
  • A good vitamin D status can protect against cancer - Science Daily, 6/10/20 - "A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment of colon cancer and blood cancers. In addition, high vitamin D responsiveness can be linked to a smaller cancer risk ... individuals differ in their molecular response or sensitivity to vitamin D supplementation. For example, 25% of the Finnish population seem to be low responders, needing a higher dose of vitamin D supplementation to reach the full clinical benefit. In terms of cancer risk, being a high responder can be expected to have a protective effect" - See vitamin D at Amazon.com and vitamin D at iHerb.
  • A combo of fasting plus vitamin C is effective for hard-to-treat cancers, study shows - Science Daily, 5/12/20 - "while fasting remains a challenging option for cancer patients, a safer, more feasible option is a low-calorie, plant-based diet that causes cells to respond as if the body were fasting. Their findings suggest that a low-toxicity treatment of fasting-mimicking diet plus vitamin C has the potential to replace more toxic treatments ... When used alone, fasting-mimicking diet or vitamin C alone reduced cancer cell growth and caused a minor increase in cancer cell death. But when used together, they had a dramatic effect, killing almost all cancerous cells ... Longo and his colleagues detected this strong effect only in cancer cells that had a mutation that is regarded as one of the most challenging targets in cancer research. These mutations in the KRAS gene signal the body is resisting most cancer-fighting treatments, and they reduce a patient's survival rate. KRAS mutations occur in approximately a quarter of all human cancers and are estimated to occur in up to half of all colorectal cancers ... The research team's prior studies showed that fasting and a fasting-mimicking diet slow cancer's progression and make chemotherapy more effective in tumor cells, while protecting normal cells from chemotherapy-associated side effects. The combination enhances the immune system's anti-tumor response in breast cancer and melanoma mouse models ... At least five clinical trials, including one at USC on breast cancer and prostate cancer patients, are now investigating the effects of the fasting-mimicking diets in combination with different cancer-fighting drugs" - See vitamin C products at Amazon.com and vitamin C at iHerb.com.
  • Daily Aspirin Tied to Lower Risk of Various Digestive Cancers - NYT, 4/21/20 - "Researchers pooled data from 113 studies and found that daily aspirin use among people aged 40 to 75 was associated with a 27 percent reduction in the risk for colorectal cancer, a 36 percent reduction in stomach cancer, a 33 percent reduction in esophageal cancer, a 38 percent reduction in liver and gallbladder cancer, and a 22 percent reduction in pancreatic cancer. For all these tumors, the favorable effect increased with duration of use"
  • Statins starve cancer cells to death - Science Daily, 3/12/20 - "Devreotes and his team began the new study with an unbiased screen of about 2,500 drugs approved by the U.S. Food and Drug Administration (FDA) to see which ones had the best kill rate of cells genetically engineered to have a mutation in a cancer gene called PTEN. The gene codes for an enzyme that suppresses tumor growth. Among the thousands of drugs, statins and in particular pitavastatin, emerged as a top contender in cancer-killing ability. Most of the other drugs had no effect or killed normal and engineered cells at the same rate. Equal concentrations of pitavastatin caused cell death in nearly all of the engineered cells, but very in few normal cells"
    • Pitavastatin - wikipedia.org - "It was patented in 1987 and approved for medical use in 2003.[2] It is available in Japan, South Korea and in India.[3] In the US, it received FDA approval in 2009"
  • Even a Little Alcohol May Raise Cancer Risk - NYT, 12/9/19 - "the equivalent of six ounces of wine, 17 ounces of beer or two ounces of whiskey a day for 10 years increased the relative risk of cancer by 5 percent. After two drinks a day for 40 years, the relative risk of having any cancer increased by 54 percent compared with a nondrinker. The associations were particularly strong for cancers of the mouth, throat, stomach and colon"
  • Low-Dose Aspirin Might Cut Cancer Risk - WebMD, 12/4/19 - "Low-dose aspirin reduced overall cancer death risk by 15% and all-cause death by 19% among more than 146,000 people who participated in a cancer screening trial conducted between 1993 and 2008 ... Overweight folks also experienced a marked decline in their risk of death from gastrointestinal cancer (28%) and colon cancer (34%)"
  • Creatine powers T cells' fight against cancer - Science Daily, 10/18/19 - "Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer ... Taken together, these findings suggest that killer T cells really need creatine to fight cancer ... Without it, they simply can't do their jobs effectively ... These new findings add killer T cells to the list of creatine-dependent cells, all of which utilize two distinct sources of power, much like hybrid cars. The first power source is a metabolic process that is similar to a fuel engine, converting nutrients like glucose, amino acids and lipids into ATP, the energy currency of cells. The secondary power source is creatine, which -- like a hybrid car's battery -- absorbs excess energy (in this case, ATP) and stores it to be released when fuel is in short supply to keep the cells working until more fuel can be burned" - See creatine at Amazon.com.
  • Vitamin D and fish oil show promise in prevention of cancer death and heart attacks - Science Daily, 9/24/19 - "Nearly 26,000 U.S. men and women participated in the nationwide VITAL clinical trial. After more than five years of study and treatment, the results show promising signals for certain outcomes. For example, while Omega-3 fatty acids (fish oil) showed only a small, but nonsignificant, reduction in the primary cardiovascular endpoint of major CVD events, they were associated with significant reductions in heart attacks. The greatest treatment benefit was seen in people with dietary fish intake below the cohort median of 1.5 servings per week but not in those whose intake was above that level. In addition, African-Americans appeared to experience the greatest risk reductions. The heart health benefits are now confirmed by recent meta-analyses of omega-3 randomized trials. ... Similarly, vitamin D supplementation did not reduce major CVD events or total cancer incidence but was associated with a statistically significant reduction in total cancer mortality among those in the trial at least two years. The effect of vitamin D in reducing cancer death is also confirmed by updated meta-analyses of vitamin D trials to date." - See vitamin D at Amazon.com and omega-3 supplements at Amazon.com.
  • Association between vitamin D supplementation and mortality: systematic review and meta-analysis BMJ. 2019 Aug 12;366:l4673 - "Vitamin D supplementation reduced the risk of cancer death by 16%. Additional large clinical studies are needed to determine whether vitamin D3 supplementation is associated with lower all cause mortality" - [Nutra USA] - See vitamin D at Amazon.com.
  • Vitamin D Supplementation and Total Cancer Incidence and Mortality - Medscape, 7/5/19 - "In an updated meta-analysis of RCTs, vitamin D supplementation significantly reduced total cancer mortality but did not reduce total cancer incidence" - See vitamin D at Amazon.com.
  • Timed release of turmeric stops cancer cell growth - Science Daily, 6/20/19 - "A Washington State University research team has developed a drug delivery system using curcumin, the main ingredient in the spice turmeric, that successfully inhibits bone cancer cells while promoting growth of healthy bone cells ... Turmeric has been used in cooking and as medicine for centuries in Asian countries, and its active ingredient, curcumin has been shown to have anti-oxidant, anti-inflammatory and bone-building capabilities. It has also been shown to prevent various forms of cancers ... However, when taken orally as medicine, the compound can't be absorbed well in the body. It is metabolized and eliminated too quickly ... The researchers found that their system inhibited the growth of osteosarcoma cells by 96 percent after 11 days as compared to untreated samples. The system also promoted healthy bone cell growth" - See curcumin products at Amazon.com.
  • Vitamin D could help cancer patients live longer - Science Daily, 6/4/19 - "Vitamin D had a significant effect on lowering the risk of death among those with cancer, but unfortunately it didn't show any proof that it could protect against getting cancer" - See vitamin D at Amazon.com.
  • Products of omega-3 fatty acid metabolism may have anticancer effects - Science Daily, 7/13/18 - "In 2017, the Illinois team identified a new group of omega-3 fatty-acid metabolites called endocannabinoid epoxides, or EDP-EAs. They found that these molecules had anti-inflammatory properties and targeted the same receptor in the body that cannabis does .... in higher concentrations, EDP-EAs did kill cancer cells, but not as effectively as other chemotherapeutic drugs on the market. However, the compounds also combated the osteosarcoma in other ways: They slowed tumor growth by inhibiting new blood vessels from forming to supply the tumor with nutrients, they prevented interactions between the cells, and most significantly, they appeared to stop cancerous cells from migrating" - See fish oil supplements at Amazon.com.
  • Choose Omega-3s from fish over flax for cancer prevention, study finds - Science Daily, 1/26/18 - "overall exposure to marine-based omega-3s reduced the size of the tumours by 60 to 70 per cent and the number of tumours by 30 per cent ... However, higher doses of the plant-based fatty acid were required to deliver the same impact as the marine-based omega-3s ... Omega-3s prevent and fight cancer by turning on genes associated with the immune system and blocking tumour growth pathways ... Besides certain foods containing EPA and DHA, supplements and functional foods, such as omega-3 eggs or DHA milk, can offer similar cancer prevention effects" - See fish oil supplements at Amazon.com.
  • Decongestant revealed as 'highly effective' in starving cancer cells - Science Daily, 11/21/17 - "Patients taking high dosages of NAC saw their levels of the 'transporter' protein fall by more than 80%, drastically reducing the ability of the cancer cells to feed off neighbouring cells" - See n-acetyl cysteine at Amazon.com.
  • Epigallocatechin-3-Gallate: The Prospective Targeting of Cancer Stem Cells and Preventing Metastasis of Chemically-Induced Mammary Cancer in Rats - Am J Med Sci. 2017 Jul;354(1):54-63 - "It was found that epigallocatechin-3-gallate exhibited significant chemopreventive effects and anti-cancer stem cell activity through several pathways, including a significant decrease in the size and number of tumors per rat, significant amelioration of the oxidative stress markers' alterations and significant inhibition of CD44, VEGF, Ki-67 and MMP-2 expression associated with a significantly increased expression of caspase-3 ... Additionally, the combination of epigallocatechin-3-gallate and paclitaxel significantly enhanced the later anticancer efficacy ... Epigallocatechin-3-gallate could be offered as an unprecedented curative strategy to eradicate cancer" - See green tea extract at Amazon.com.
  • Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells - Science Daily, 5/12/17 - "The Salford team recently showed Vitamin C to be up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, but they say that when Vitamin C is combined with an antibiotic, it is up to ten times more effective, making it nearly 100 times more effective than 2-DG ... As Doxycycline and Vitamin C are both relatively non-toxic, this could dramatically reduce the possible side-effects of anti-cancer therapy ... The Salford team also identified eight other drugs that could be used as a "second-punch" after the antibiotic regime, including berberine (a natural product) -- and a number of cheap non-toxic FDA approved drugs" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
  • L-leucine dietary supplementation modulates muscle protein degradation and increases pro-inflammatory cytokines in tumour-bearing rats - Cytokine. 2017 May 8;96:253-260 - "the leucine-supplemented tumour-bearing groups showed improvements in muscle mass and protein content, and in this specific situation, the leucine-rich diet led to an increase on the day in cytokine profile and proteasome subunits mainly on the 14th day, which subsequently had a modulating effect on tumour growth on the 21st day. These results indicate that the presence of leucine in the diet may modulate important aspects of the proteasomal pathway in cancer cachexia and may prevent muscle wasting due to the decrease in the cachexia index" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram) at Amazon.com.
  • High doses of vitamin C to improve cancer treatment passes human safety trial - Science Daily, 3/30/17 - "Clinical trials found that it is safe to regularly infuse brain and lung cancer patients with 800 -- 1000 times the daily recommended amount of vitamin C as a potential strategy to improve outcomes of standard cancer treatments ... This guarded optimism is based on the phase I trial data showing an increase in overall survival of 4-6 months in 11 glioblastoma multiforme patients (18-22 months) versus the 14-16 months survival typically seen with the standard treatment"
  • Does Vitamin D decrease risk of cancer? - Science Daily, 3/28/17 - "Participants were randomly assigned to take either 2000 international units (IU) of vitamin D3 and 1500 mg. of calcium or identical placebos daily for 4 years ... Women who were given vitamin D3 and calcium supplements had 30% lower risk of cancer ... Cedric Garland, a co-investigator at the University of California San Diego said "This is the most important scientific study of this century to date."" - See vitamin D at Amazon.com.
  • Vitamin C effective in targeting cancer stem cells - Science Daily, 3/8/17 - "Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products -- caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid -- and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG ... While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
  • Effects of combined treatment with branched-chain amino acids, citric acid, L-carnitine, coenzyme Q10, zinc, and various vitamins in tumor-bearing mice - Biol Pharm Bull. 2017 Jan 26 - "A functional dietary supplement (FDS) containing Coenzyme Q10, Branched-chain Amino Acids and L-carnitine was administered to tumor-bearing mice, investigating its effects on tumor and muscle tissues ... The median survival time was comparable (21 days in the FDS group vs. 18 days in the control group, p=0.30). However, cumulative food intake was significantly higher in the FDS group than the control group (p=0.011). Metastasis of melanoma to the lung was observed in the control group but not in the FDS group (p=0.043). The weight of the suprahyoid muscles was significantly higher in the FDS group than in the control group (p=0.0045). The weight of the tumor was significantly lower in the FDS group than in the control group (p=0.013). The results possibly suggest oral administration of FDS in tumor-bearing mice enhances the maintenance of suprahyoid muscle mass, resulting in an extended feeding period and suppression of tumor growth and metastasis"
  • Why high-dose vitamin C kills cancer cells - Science Daily, 1/9/17 - "Vitamin C has a patchy history as a cancer therapy, but researchers at the University of Iowa believe that is because it has often been used in a way that guarantees failure ... Most vitamin C therapies involve taking the substance orally. However, the UI scientists have shown that giving vitamin C intravenously -- and bypassing normal gut metabolism and excretion pathways -- creates blood levels that are 100 -- 500 times higher than levels seen with oral ingestion. It is this super-high concentration in the blood that is crucial to vitamin C's ability to attack cancer cells" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
  • Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis - J Natl Cancer Inst. 2016 Oct 30;109(3) - "Epidemiological evidence supports the potential of vitamin B6 as a cancer risk reduction agent and the role of PLP as a cancer screening biomarker, especially for gastrointestinal tumors. However, inconsistent findings from total intake and intervention studies suggest that vitamin B6 might also be an indicator of other dietary protective micronutrients" - See Best Naturals Vitamin B-6 25 mg 250 Tablets at Amazon.com.
  • Higher levels of vitamin D correspond to lower cancer risk - Science Daily, 4/6/16 - "The new PLOS ONE study sought to determine what blood level of vitamin D was required to effectively reduce cancer risk ... Cancer incidence declined with increased 25(OH)D. Women with 25(OH)D concentrations of 40 ng/ml or greater had a 67 percent lower risk of cancer than women with levels of 20 ng/ml or less ... Garland said a broad effort to increase 25(OH)D concentrations to a minimum of 40 ng/ml in the general population would likely and substantially reduce cancer incidence and associated mortality" -  Note:  40 ng/ml equals 100 nmol/l.  They usually used ng/ml in the U.S.  See vitamin D at Amazon.com.
  • The Dietary Inflammatory Index Is Associated with Prostate Cancer Risk in French Middle-Aged Adults in a Prospective Study - J Nutr. 2016 Mar 9 - "Chronic inflammation is one of the mechanisms involved in carcinogenesis. Diet is a major source of pro- and anti-inflammatory compounds ... Consistent with mechanistic data, findings from this study indicated that proinflammatory diets are associated with increased prostate cancer risk and, in low-to-moderate alcohol drinkers, with increased overall and breast cancer risk"
  • Combination chemoprevention with grape antioxidants - Mol Nutr Food Res. 2016 Feb 1 - "Antioxidant ingredients present in grape have been extensively investigated for their cancer chemopreventive effects. However, much of the work has been done on individual ingredients, especially focusing on resveratrol and quercetin. Phytochemically, whole grape represents a combination of numerous phytonutrients. Limited research has been done on the possible synergistic/additive/antagonistic interactions among the grape constituents. Among these phytochemical constituents of grapes, resveratrol, quercetin, kaempferol, catechin, epicatechin, and anthocyanins (cyanidin and malvidin) constitute more than 70% of the grape polyphenols ... While a wealth of information is available individually on cancer chemopreventive/anti-proliferative effects of resveratrol and quercetin, limited information is available regarding the other major constituents of grape ... Based on strong rationale emanating from published studies, it seems probable that a combination of multiple grape-ingredients alone or together with other agents could impart 'additive synergism' against cancer" - See grape seed extract at Amazon.com.
  • Tocopherols in cancer: An update - Mol Nutr Food Res. 2016 Jan 11 - "Large scale clinical trials with α-tocopherol provided inconsistent results regarding the cancer preventive activities of tocopherols ... The experimental data provide strong evidence in support of the anti-cancer activities of δ-tocopherol, γ-tocopherol and the natural tocopherol mixture rich in γ-tocopherol, γ-TmT, over α-tocopherol" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Here's How Sugar Might Fuel the Growth of Cancer - NBC News, 12/31/15 - "Sucrose or table sugar is actually composed of two sugars: glucose and fructose ... Fructose is processed more by the liver, glucose by the pancreas ... When the mice got more fructose, they grew larger tumors and faster ... This supports other findings that have shown pancreatic tumors also thrive on fructose ... It seems that fructose is driving this inflammatory process more than glucose ... It seems from these series of experiments that it really fructose that within the sucrose that is the driver of the tumorigenic process ... Any sugar helped make the tumors grow faster, but fructose did it significantly more"
  • Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway - Mol Nutr Food Res. 2015 Aug 27 - "Resveratrol is a natural occurring polyphenol with several health promoting activities, including anticancer potential ... Resveratrol may have therapeutic potential against myeloproliferative neoplasms associated with the aberrant activation of the JAK2 pathway" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.
  • Fish Oil Enhances T Cell Function and Tumor Infiltration and Is Correlated With a Cancer Prevention Effect in HER-2/neu But Not PyMT Transgenic Mice - Nutr Cancer. 2015 Jul 30 - "FO significantly reduced the incidence and multiplicity of tumors (P < 0.001) in HER-2/neu, but not PyMT mice" - See fish oil supplements at Amazon.com.
  • Omega-3 fatty acids may help improve treatment, quality of life in cancer patients - Science Daily, 7/28/15 - "The study found evidence of activity in response and disease stabilization rates, reduction in liver metastasis volume, and improved quality of life scores in this group of patients" - See fish oil supplements at Amazon.com.
  • Vegetable Intake, but Not Fruit Intake, Was Associated with a Reduction in the Risk of Cancer Incidence and Mortality in Middle-Aged Korean Men - J Nutr. 2015 Apr 15 - "Total vegetable intake was linearly associated with cancer incidence but was nonlinearly associated with cancer mortality; by comparing ≥500 g/d with <100 g/d of total vegetable intake, the multivariable-adjusted RR for total cancer incidence was 0.72 ... No associations were found between total fruit intake and total cancer incidence and mortality"
  • Diet Quality and Survival After Ovarian Cancer: Results From the Women's Health Initiative - J Natl Cancer Inst. 2014 Oct 21;106(11) - "Overall, higher diet quality was associated with lower all-cause mortality after ovarian cancer (hazard ratio [HR] for highest vs lowest tertile = 0.73"
  • Synergistic inhibition of cancer cell proliferation with a combination of δ-tocotrienol and ferulic acid - Biochem Biophys Res Commun. 2014 Oct 3 - "Rice bran consists of many functional compounds and thus much attention has been focused on the health benefits of its components. Here, we investigated the synergistic inhibitory effects of its components, particularly δ-tocotrienol (δ-T3) and ferulic acid (FA), against the proliferation of an array of cancer cells, including DU-145 (prostate cancer), MCF-7 (breast cancer), and PANC-1 (pancreatic cancer) cells. The combination of δ-T3 and FA markedly reduced cell proliferation relative to δ-T3 alone, and FA had no effect when used alone" - Note:  δ is the delta form.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com and ferulic acid at Amazon.com.
  • Prediabetes increases the risk of cancer by 15 percent, study of almost 900,000 people shows - Science  Daily, 9/8/14 - "after controlling for BMI, the presence of prediabetes remained associated with an increased risk of cancer of 22% ... In a site-specific cancer analysis, prediabetes was significantly associated with increased risks of cancer of the stomach/colorectum (relative risk, RR 1.55), liver (RR 2.01), pancreas (RR 1.19), breast (RR 1.19) and endometrium (RR 1.60) (all statistically significant), but not associated with cancer of the bronchus/lung, prostate, ovary, kidney or bladder ... several possible mechanisms could explain the results. First, chronic hyperglycaemia and its related conditions, such as chronic oxidative stress and the accumulation of advanced glycated endproducts (that are made in conditions of excessively high blood sugar) may act as carcinogenic factors. Second, increased insulin resistance leads to increased insulin secretion, which can in turn allow cancer cells to grow and divide ... It should be noted that metformin -- one of several first line therapies available to treat type 2 diabetes -- is now considered as having some 'protective' anticancer properties. Notably, metformin mediates an approximately 30% reduction in the lifetime risk of cancer in diabetic patients. However, whether this is true in prediabetic individuals is not yet known" - See metformin at The Antiaging Store.
  • Vitamin D may raise survival rates among cancer patients - Science Daily, 4/29/14 - "The meta-analysis looked at the results of 25 separate studies that measured vitamin D levels in cancer patients at the time of diagnosis and tracked survival rates. In most of the research, patients had their vitamin D levels tested before they underwent any treatment for cancer. The study found a 10 nmol/L increase in vitamin D levels was tied to a 4 percent increase in survival among people with cancer ... Researchers found the strongest link between vitamin D levels and survival in breast cancer, lymphoma and colorectal cancer" - See vitamin D at Amazon.com.
  • The prognostic value of metformin for cancer patients with concurrent diabetes- a systematic review and meta-analysis - Diabetes Obes Metab. 2014 Jan 27 - "A literature search was performed using the PubMed, EMbase and SciVerse Scopus databases ... metformin was associated with lower risk of all-cause mortality in cancer patients with concurrent diabetes, particularly for breast (pooled relative risk (RR) 0.70, 95% CI 0.55, 0.88; P=0.003), colorectal (RR 0.70, 95% CI 0.59, 0.84; P<0.001), ovarian (RR 0.44, 95% CI 0.30, 0.64; P<0.001) and endometrial cancer (RR 0.49, 95% CI 0.32, 0.73; P=0.001). In addition, metformin was associated with lower risks of cancer-specific mortality" - See metformin at The Antiaging Store.
  • Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia - Cancer Lett. 2014 Jan 21 - "We present here how metformin, an anti-diabetic drug that has attracted a strong interest for its recently discovered anti-cancer properties, can be envisioned as a new adjuvant approach to treat leukemia. Metformin may have a double-edged sword effect i) by acting on the organism to decrease hyperglycaemia and hyperinsulinemia in diabetic patients and ii) at the cellular level, by inhibiting the mTORC1-cancer supporting pathway through AMPK-dependent and independent mechanisms" - See metformin at The Antiaging Store.
  • Calcium + Vitamin D: Surprises From Long-term Follow-up - Medscape, 12/11/13 - "In terms of all cancers, among the women who had low baseline intake of vitamin D, there was a statistically significant 9% reduction in total cancer with supplementation" - See vitamin D at Amazon.com.
  • Antitumor and anti-cachectic effects of shark liver oil and fish oil: comparison between independent or associative chronic supplementation in Walker 256 tumor-bearing rats - Lipids Health Dis. 2013 Oct 16;12(1):146 - "Shark liver oil (SLOil) and fish oil (FOil), which are respectively rich in alkylglycerols (AKGs) and n-3 polyunsaturated fatty acids (PUFAs), are able to reduce the growth of some tumors and the burden of cachexia. It is known that FOil is able to reduce proliferation rate and increase apoptotic cells and lipid peroxidation of tumor cells efficiently ... Weanling male Wistar rats were divided into 4 groups: fed regular chow (C), supplemented (1g/kg body weight) with SLOil (CSLO), FOil (CFO) and both (CSLO + FO) ... Fourteen days after inoculation, SLOil was able to restore cachexia parameters to control levels, similarly to FOil. WSLO rats presented significantly lower tumor weight (40%), greater tumor cell apoptosis (~3-fold), decreased tumor cell proliferation (35%), and higher tumor content of lipid hydroperoxides (40%) than observed in W rats, but FOil showed more potent effects. Supplementation with SLOil + FOil did not promote additive effects" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Red Wine Chemical, Resveratrol, Remains Effective Against Cancer After the Body Converts It - Science Daily, 10/2/13 - "it had previously been thought that levels of the extracted chemical drop too quickly to make it usable in clinical trials ... Enzymes within cells are then able to break it down into resveratrol again -- meaning that levels of resveratrol in the cells are higher than was previously thought ... The study also showed that resveratrol generated from resveratrol sulfate is able to slow the growth of cancer cells by causing them to digest their own internal constituents and stopping them from dividing ... There is a lot of strong evidence from laboratory models that resveratrol can do a whole host of beneficial things -- from protecting against a variety of cancers and heart disease to extending lifespan" - See resveratrol products at Amazon.com.
  • Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue - Medscape, 9/27/13 - "cancer-related fatigue (CRF) ... A multisite, double-blind trial randomized fatigued cancer survivors to 2000mg of American ginseng vs a placebo for 8 weeks ... Multidimensional Fatigue Symptom Inventory–Short Form (MFSI-SF) ... A statistically significant difference was seen at 8 weeks with a change score of 20 (SD = 27) for the ginseng group and 10.3 (SD = 26.1) for the placebo group (P = .003). Greater benefit was reported in patients receiving active cancer treatment vs those who had completed treatment. Toxicities per self-report and CTCAE grading did not differ statistically significantly between arms" - See ginseng at Amazon.com.
  • Serum Antioxidant Nutrients, Vitamin A, and Mortality in US Adults - Cancer Epidemiol Biomarkers Prev. 2013 Jul 29 - "We evaluated all-cause, cancer and cardiovascular mortality risks associated with quintiles (Q1-Q5) of serum antioxidant (vitamins C and E, beta-carotene, and selenium) and vitamin A levels, in 16,008 adult NHANES III (The Third National Health and Nutrition Examination survey, 1988-1994) participants ... median follow-up period of 14.2 years ... We observed a dose-response decrease in cancer and overall mortality risks with higher vitamin C levels. In contrast, for vitamin A, risk of cancer death decreased from Q1-Q2, with no further decline in risk at higher levels. For vitamin E, having levels in Q4 were associated with the lowest cancer mortality risk. Both vitamin A and E had U-shaped associations with all-cause mortality. Cancer mortality risks decreased from Q1-Q2 for beta-carotene and from Q1-Q4 for selenium. However, for beta-carotene and selenium, overall mortality risks decreased from Q1-Q2 but then did not change significantly with higher levels"
  • Effects of Metformin Dose on Cancer Risk Reduction in Patients with Type 2 Diabetes Mellitus: A 6-Year Follow-up Study - Pharmacotherapy. 2013 Jul 17 - "Longitudinal Health Insurance Database ... A total of 65,754 age- and gender-matched patients without diabetes and no previous cancer diagnosis were extracted from the database ... Our results revealed dose-dependent effects of metformin on cancer risk and cancer onset times. A significant decrease in cancer risk was found in the monotherapy group who received more than 360 defined daily doses (DDDs) of metformin (hazard ratio [HR] 0.40, 95% confidence interval [CI] 0.24-0.66). The greatest decrease in cancer risk was observed in patients who took more than 1080 DDDs (HR 0.27, 95% CI 0.09-0.84). Significantly greater dose-dependent effects were seen in patients who used metformin in combination with other antidiabetic drugs" - See metformin at The Antiaging Store.
  • Excess sugar linked to cancer - Science Daily, 2/1/13 - "Dr Garcia Jimenez's laboratory was studying how cells in the intestine respond to sugars and signal to the pancreas to release insulin, the key hormone that controls blood sugar levels. Sugars in the intestine trigger cells to release a hormone called GIP that enhances insulin release by the pancreas ... the ability of the intestinal cells to secrete GIP is controlled by a protein called β-catenin, and that the activity of β-catenin is strictly dependent on sugar levels ... high (but not normal) sugar levels induce nuclear accumulation of β-catenin and leads to cell proliferation"
  • Omega-3 fatty acids in cancer - Curr Opin Clin Nutr Metab Care. 2013 Jan 7 - "Inflammation dictates tumour initiation, progression and growth. Omega-3 fatty acids exert anti-inflammatory effects, and therefore recent studies investigated their role in cancer prevention, in cancer cachexia treatment and in enhancement of antitumour therapies. Limited evidence suggests a role for omega-3 fatty acid supplementation in cancer prevention, but they have been shown to preserve muscle mass and function in cancer patients even during active treatment. During chemotherapy, omega-3 fatty acids may contribute to a reduced inflammatory response, but whether cancer treatment toxicity can be prevented remains to be assessed. Finally, small studies showed that omega-3 fatty acids increase response rate to chemotherapy" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase - Biochem Biophys Res Commun. 2013 Jan 3 - "Systemic administration of resveratrol suppressed tumor growth in EG7 thymoma-bearing mice in an IDO-dependent manner" - See resveratrol products at Amazon.com.
  • Antitumor effects of dietary black and brown rice brans in tumor-bearing mice: Relationship to composition - Mol Nutr Food Res. 2012 Dec 23 - "Black and brown rice brans from Oryza sativa LK1-3-6-12-1 and Chuchung cultivars each contained 21 compounds characterized by GC/MS [gas chromatography–mass spectrometrgas chromatography–mass spectrometry]. Mice fed diets with added rice brans for 2 weeks were intracutaneously inoculated with CT-26 mouse cancer cells and fed the same diet for two additional weeks. Tumor mass was 35 and 19% lower in the black and brown bran-fed groups, respectively" - See brown rice pasta at Amazon.com.
  • Diabetes Drug Metformin May Fight Cancer - WebMD, 12/3/12 - "The study is just one of dozens under way worldwide examining the drug -- which costs just pennies a pill -- as a treatment for breast, colon, prostate, pancreatic, and ovarian cancers ... After five years, 67% of women who took metformin had not died from ovarian cancer, compared to 47% of women without diabetes who did not take the drug ... The survival difference in the two groups was striking ... Every way we looked at this, the metformin group always did better ... If metformin really does fight cancer, it may do so by lowering circulating insulin levels in the blood" - [Science Daily] - See metformin at The Antiaging Store.
  • Raf and PI3K are the Molecular Targets for the Anti-metastatic Effect of Luteolin - Phytother Res. 2012 Nov 21 - "Metastases are the primary cause of human cancer deaths. Luteolin, a naturally occurring phytochemical, has chemopreventive and/or anticancer properties in several cancer cell lines ... An in vivo mouse study showed that oral administration (10 or 50 mg/kg) of luteolin significantly inhibited tumor nodules and tumor volume of lung metastasis induced by intravenous injection of CT-26 cells. Luteolin also inhibited MMP-9 expression and activity in CT-26-induced mouse lung tissue. These results suggest that luteolin may have considerable potential for development as an anti-metastatic agent" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
    • Luteolin - Wikipedia, the free encyclopedia - "Luteolin is a yellow crystalline compound. It is a flavonoid; to be specific, it is one of the more common flavones.[1] From preliminary research, it is thought to play a role in the human body possibly as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune system modulator"
  • Vegetarian diets and the incidence of cancer in a low-risk population - Cancer Epidemiol Biomarkers Prev. 2012 Nov 20 - "cancer incidence among 69,120 participants of the Adventist Health Study-2 ... The multivariate HR of overall cancer risk among vegetarians compared to non-vegetarians was statistically significant (HR=0.92; 95%CI: 0.85, 0.99) for both genders combined. Also, a statistically significant association was found between vegetarian diet and cancers of the gastrointestinal tract (HR=0.76; 95%CI: 0.63, 0.90). When analyzing the association of specific vegetarian dietary patterns, vegan diets showed statistically significant protection for overall cancer incidence (HR=0.84; 95%CI: 0.72, 0.99) in both genders combined and for female-specific cancers (HR=0.66; 95%CI: 0.47, 0.92). Lacto-ovo-vegetarians appeared to be associated with decreased risk of cancers of the gastrointestinal system (HR=0.75; 95%CI: 0.60, 0.92)"
  • Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial - JAMA. 2012 Nov 14;308(18):1871-80 - "A large-scale, randomized, double-blind, placebo controlled trial (Physicians" Health Study II) of 14 641 male US physicians initially aged 50 years or older (mean [SD] age, 64.3 [9.2] years), including 1312 men with a history of cancer at randomization, enrolled in a common multivitamin study that began in 1997 with treatment and follow-up through June 1, 2011 ... In this large prevention trial of male physicians, daily multivitamin supplementation modestly but significantly reduced the risk of total cancer" - I think this was the following which I published last month:
    • Multivitamins Cut Cancer Risk in Men, Study Finds - ABC News, 10/17/12 - "a new study of almost 15,000 men over 50 suggests popping that daily supplement could cut cancer rates by 8 percent ... It's unclear whether the results apply to women or men under 50 ... First, the new study randomly assigned men to two groups, one of which took a daily Centrum Silver® while the other took a placebo pill ... Second, it followed the men, who were 65 years old on average, over 11 years – a longer follow-up than previous studies and sufficient time for cancer to develop ...Other trials have tested a single vitamin such as calcium or vitamin A, E or D in large doses, which is very different from how people normally get the vitamins and minerals they need from food" - Yeah but I wouldn't call Centrum Silver a top of the line supplement.  Click here and click on "Product Labeling" for ingredients.  Some examples; it's only has the synthetic dl-Alpha Tocopheryl Acetate form of vitamin E plus there are 8 forms of that vitamin.  There are over 600 carotenoids and some claim taking just one of those can cause a deficiency of the others, etc.  See Garden of Life, Vitamin Code, 50 & Wiser Men at Amazon.com and Garden of Life, Vitamin Code, 50 & Wiser Women at Amazon.com.
  • Night-Shift Work Ups the Risk for Various Cancers in Men - Medscape, 10/31/12 - "The study compared 3137 men with cancer and 512 matched control subjects who completed a detailed questionnaire about occupational work and lifestyle from 1979 to 1985 ... Compared with men who never worked at night, men who worked night shifts had an increased risk for prostate cancer (odds ratio [OR], 2.77), non-Hodgkin's lymphoma (OR, 2.31), pancreatic cancer (OR, 2.27), rectal cancer (OR, 2.09), colon cancer (OR, 2.03), bladder cancer (OR, 1.74), and lung cancer (OR, 1.76) ... "When I first proposed the light-at-night hypothesis, it linked circadian disturbance to hormone disruption and breast cancer," Dr. Stevens explained. Since then, circadian disruption has been linked to many other adverse effects, it has been demonstrated that melatonin has a direct effect on tumor growth, and some of the latest research he has been involved with has shown that circadian disruption has an epigenetic impact" - See melatonin at Amazon.com.
  • Multivitamins Cut Cancer Risk in Men, Study Finds - ABC News, 10/17/12 - "a new study of almost 15,000 men over 50 suggests popping that daily supplement could cut cancer rates by 8 percent ... It's unclear whether the results apply to women or men under 50 ... First, the new study randomly assigned men to two groups, one of which took a daily Centrum Silver® while the other took a placebo pill ... Second, it followed the men, who were 65 years old on average, over 11 years – a longer follow-up than previous studies and sufficient time for cancer to develop ...Other trials have tested a single vitamin such as calcium or vitamin A, E or D in large doses, which is very different from how people normally get the vitamins and minerals they need from food" - Yeah but I wouldn't call Centrum Silver a top of the line supplement.  Click here and click on "Product Labeling" for ingredients.  Some examples; it's only has the synthetic dl-Alpha Tocopheryl Acetate form of vitamin E plus there are 8 forms of that vitamin.  There are over 600 carotenoids and some claim taking just one of those can cause a deficiency of the others, etc.
  • Mushroom-Derived Compound Lengthens Survival in Dogs With Cancer, Study Suggests - Science Daily, 9/10/12 - "The Coriolus versicolor mushroom, known commonly as the Yunzhi mushroom, has been used in traditional Chinese medicine for more than 2,000 years. The compound in the mushroom that is believed to have immune-boosting properties is polysaccharopeptide, or PSP ... We were shocked ... Prior to this, the longest reported median survival time of dogs with hemangiosarcoma of the spleen that underwent no further treatment was 86 days. We had dogs that lived beyond a year with nothing other than this mushroom as treatment" -  See Yun Zhi at Amazon.com and Coriolus versicolor at Amazon.com
  • Diindolilmethane (DIM) selectively inhibits cancer stem cells - Biochem Biophys Res Commun. 2012 Jun 19 - "Epidemiologic studies repeatedly have shown chemopreventive effects of cruciferous vegetables. Indole-3-carbinol (I3C) and its metabolite diindolylmethane (DIM) were identified in these plants as active ingredients and theirs anti-tumor activities were confirmed in multiple in vitro and in vivo experiments. Here, we demonstrate that DIM is a selective and potent inhibitor of cancer stem cells (CSCs). In several cancer cell lines, DIM inhibited tumor sphere formation at the concentrations 30-300 times lower than concentrations required for growth inhibition of parental cells cultured as adherent culture. We also found that treatment with DIM overcomes chemoresistance of CSCs to cytotoxics, such as paclitaxel, doxorubicin, and SN-38 ... DIM can potentially be used in cancer patients, either alone, or in combinations with existing drugs" - See diindolylmethane at Amazon.com.
  • Metformin may lower cancer risk in people with type 2 diabetes - Science Daily, 6/25/12 - "the odds of getting any type of cancer was 0.62 times less -- an estimated 38 percent relative risk reduction -- with daily continuous use of metformin than for those with no exposure to metformin ... This risk reduction with metformin use extended to certain types of cancers, specifically colon and breast cancer ... Metformin, which is the standard recommended initial treatment of Type 2 diabetes, may protect against cancer because it regulates activity of an enzyme that suppresses cell growth" - See metformin at The Antiaging Store.
  • Ginseng May Banish Cancer Fatigue, New Study Finds - ABC News, 6/4/12 - "Researchers gave 2,000 milligrams of pure ground American ginseng or a placebo pill to 340 patients being treated for cancer and cancer survivors who had finished their treatment. After four weeks, patients reported little change in their cancer-related fatigue. But after eight weeks, the patients taking ginseng reported feeling generally more energized than their sugar pill-popping peers. The response was particularly strong among patients who were currently undergoing cancer treatment ... Some studies have shown that ginseng decreases inflammation and the stress hormone cortisol, both of which may be contributing factors to cancer-related fatigue ... Extracts of ginseng that are alcohol based change a characteristic of the ginseng to be somewhat estrogenic ... Stay with very reputable companies" - See ginseng at Amazon.com.
  • Vitamin E in diet protects against many cancers, study suggests - Science Daily, 4/23/12 - "Our message is that the vitamin E form of gamma-tocopherols, the most abundant form of vitamin E in the American diet, and delta-tocopherols, also found in vegetable oils, are beneficial in preventing cancers while the form of vitamin E, alpha- tocopherol, the most commonly used in vitamin E supplements, has no such benefit ... the most commonly used form of vitamin E supplements, alpha-tocopherol, not only did not prevent prostate cancer, but its use significantly increased the risk of this disease among healthy men" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Aspirin reduces cancer risk: Is it time to include it in cancer prevention guidelines? - Science Daily, 4/9/12 - "In six primary prevention trials of daily low-dose aspirin, randomization to aspirin treatment was associated with an approximately 20% reduction in overall cancer incidence between 3 and 5 years after initiation of the intervention (metaodds ratio [OR] = 0.81; 95% CI 0.67-0.98) and a 30% reduction during follow up more than 5 years after randomization (meta-OR = 0.70; 95% CI 0.56-0.88). Cancer mortality was also reduced during study follow up that happened more than 5 years after the start of aspirin use (meta-OR = 0.63; 95% CI 0.49-0.82) in analyses that included 34 trials of daily aspirin at various doses. Surprisingly, the size of the observed benefit did not increase with daily doses of aspirin above 75-100 mg"
  • Daily Aspirin May Help Prevent and Treat Cancer - WebMD, 3/20/12 - "analyzed data from 51 trials originally designed to examine the impact of daily aspirin on heart attack and stroke risk ... taking a low-dose aspirin every day reduced the risk of death from cancer by 37% after at least five years of use ... In a second study, the researchers examined the impact of daily aspirin therapy on cancer metastasis, or spread, by analyzing newly published data from five other large trials ... Over an average follow-up of six-and-a-half years, daily aspirin use was associated with a 36% reduced risk of cancer with distant spread"
  • n-3 polyunsaturated fatty acids: the potential role for supplementation in cancer - Curr Opin Clin Nutr Metab Care. 2012 Feb 23 - "Low n-3 fatty acids are associated with loss of skeletal muscle, suggesting a need for supplementation ... Recent evidence appears to favour providing n-3 fatty acids early in the disease trajectory, during antineoplastic therapy for preservation of muscle and also to improve treatment tolerance" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Eat your broccoli: Another mechanism discovered by which sulforaphane prevents cancer - Science Daily, 2/28/12 - "it provides not just one, but two ways to prevent cancer through the complex mechanism of epigenetics ... Epigenetics, an increasing focus of research around the world, refers not just to our genetic code, but also to the way that diet, toxins and other forces can change which genes get activated, or "expressed." This can play a powerful role in everything from cancer to heart disease and other health issues ... HDAC inhibitors, such as sulforaphane, can help restore proper balance and prevent the development of cancer. This is one of the most promising areas of much cancer research. But the new OSU studies have found a second epigenetic mechanism, DNA methylation, which plays a similar role" - See sulforaphane at Amazon.com.
  • Vitamin D deficiency common in cancer patients - Science Daily, 10/3/11 - "More than three-quarters of cancer patients have insufficient levels of vitamin D (25-hydroxy-vitamin D) and the lowest levels are associated with more advanced cancer ... Researchers are just starting to examine how vitamin D may impact specific features of cancer, such as the stage or extent of tumor spread, prognosis, recurrence or relapse of disease, and even sub-types of cancer" - See vitamin D at Amazon.com.
  • Olive oil intake is inversely related to cancer prevalence: A systematic review and a meta-analysis of 13800 patients and 23340 controls in 19 observational studies - Lipids Health Dis. 2011 Jul 30;10(1):127 - "Dietary fat, both in terms of quantity and quality, has been implicated to cancer development, either positively or negatively. The aim of this work was to evaluate whether olive oil or monounsaturated fat intake was associated with the development of cancer. A systematic search of relevant studies, published in English, between 1990 and March 1, 2011, was performed through a computer-assisted literature tool (i.e., Pubmed). In total 38 studies were initially allocated; of them 19 case-control studies were finally studied (13800 cancer patients and 23340 controls were included). Random effects meta-analysis was applied in order to evaluate the research hypothesis. It was found that compared with the lowest, the highest category of olive oil consumption was associated with lower odds of having any type of cancer (log odds ratio = -0.41, 95%CI -0.53, -0.29, Cohran's Q=47.52, p=0.0002, I-sq=62%); the latter was irrespective of the country of origin (Mediterranean or non-Mediterranean). Moreover, olive oil consumption was associated with lower odds of developing breast cancer (logOR=-0,45 95%CI -0.78 to -0.12), and a cancer of the digestive system (logOR=-0,36 95%CI -0.50 to -0.21), compared with the lowest intake.The strength and consistency of the findings states a hypothesis about the protective role of olive oil intake on cancer risk. However, it is still unclear whether olive oil's monounsaturated fatty acid content or its antioxidant components are responsible for its beneficial effects" - Note:  That last sentence has been my question on many of the olive oil studies.  I still use my olive oil mayonnaise made with the extra light plus I take the olive oil extract capsules.  I'm not going to suffer through the taste of the extra virgin olive oil.  See olive leaf extract at Amazon.com.
  • Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms - Int J Cancer. 2011 Jul 25 - "These results suggest that luteolin possesses therapeutic potential to control the proliferation of MDR cancers without affecting the physiological function of drug transporters in the body tissues"
  • Low-carbohydrate, high-protein diets may reduce both tumor growth rates and cancer risk - Science Daily, 6/14/11 - "The first diet, a typical Western diet, contained about 55 percent carbohydrate, 23 percent protein and 22 percent fat. The second, which is somewhat like a South Beach diet but higher in protein, contained 15 percent carbohydrate, 58 percent protein and 26 percent fat. They found that the tumor cells grew consistently slower on the second diet ... As well, mice genetically predisposed to breast cancer were put on these two diets and almost half of them on the Western diet developed breast cancer within their first year of life while none on the low-carbohydrate, high-protein diet did. Interestingly, only one on the Western diet reached a normal life span (approximately 2 years), with 70 percent of them dying from cancer while only 30 percent of those on the low-carbohydrate diet developed cancer and more than half these mice reached or exceeded their normal life span ... tumor cells, unlike normal cells, need significantly more glucose to grow and thrive. Restricting carbohydrate intake can significantly limit blood glucose and insulin, a hormone that has been shown in many independent studies to promote tumor growth in both humans and mice"
  • Induction of Apoptosis by γ-Tocotrienol in Human Cancer Cell Lines and Leukemic Blasts From Patients: Dependency on Bid, Cytochrome c, and Caspase Pathway - Nutr Cancer. 2011 Jun 9:1 - "Tocotrienols (Toc3) have been suggested to possess anticancer effects besides antioxidant and antiinflammatory effects. Previous studies have demonstrated that Toc3 induce apoptosis in epithelial carcinoma. However, the effects of Toc3 on malignant hematopoietic cells have not yet been thoroughly investigated. We investigated Toc3-induced apoptosis in human hematological cancer cell lines. α-, δ-, and γ-Toc3 induced concentration-dependent apoptosis, and γ-Toc3 demonstrated more effective induction than the other Toc3 derivatives in HL-60 cells. γ-Toc3 may have induced apoptosis by activation of the caspase cascade, cytochrome c (Cyt.c) release, Bid cleavage, and mitochondorial membrane depolarization in HL-60, NB-4, Raji, and SY-5Y cells. Furthermore, 10-30 μM γ-Toc3 showed cytotoxicity for leukemic cells from various patients regardless of lymphoblastic, myeloblastic, or relapsed leukemia, but the cytotoxic effect was weak in normal mononuclear cells, interestingly. γ-Toc3 may have a role in cancer prevention and potential for treating hematological malignancies" - Note:  The γ is the gamma symbol.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo - Nutr Cancer. 2011 Jun 8:1 - "The mechanism by which cancer mediates muscle atrophy has been delineated in the past 3 decades and includes a prominent role of tumor-derived cytokines, such as IL-6, TNFα, and IL-1. These cytokines interact with their cognate receptors on muscle to activate the downstream transcription factor NF-κB and induce sarcomere proteolysis. Experimentally, inhibiting NF-κB signaling largely prevents cancer-induced muscle wasting, indicating its prominent role in muscle atrophy. Resveratrol, a natural phytoalexin found in the skin of grapes, has recently been shown to inhibit NF-κB in cancer cells, which led us to hypothesize that it might have a protective role in cancer cachexia. Therefore, we investigated whether daily oral resveratrol could protect against skeletal muscle loss and cardiac atrophy in an established mouse model. We demonstrate resveratrol inhibits skeletal muscle and cardiac atrophy induced by C26 adenocarcinoma tumors through its inhibition of NF-κB (p65) activity in skeletal muscle and heart. These studies demonstrate for the first time the utility of oral resveratrol therapy to provide clinical benefit in cancer-induced atrophy through the inhibition of NF-κB in muscle. These findings may have application in the treatment of diseases with parallel pathophysiologies such as muscular dystrophy and heart failure" - See resveratrol products at Amazon.com.
  • Supplement found to improve quality of life for female cancer survivors - Science Daily, 6/6/11 - "Interested in quality of life issues for female cancer survivors, Kathryn M. Greven, M.D., a radiation oncologist at Wake Forest Baptist, first learned of the supplement, called ArginMax for WomenTM, from a small study conducted at Stanford University that found that it improved sexual function. Sexual dysfunction is prevalent in female cancer survivors, so Greven set out to see if the supplement could produce the same benefit in this population. She found that, while taking the supplement did not result in any improvement in sexual function for female cancer survivors, the supplement did improve their overall quality of life ... The FACT-G questionnaire measures overall quality of life and has been used in research of all cancer types. It evaluates physical, emotional, social and functional well-being ... the study findings did reveal an across-the-board boost in measures of overall quality of life for the patients who were randomized to take ArginMaxTM. The FACT-G questionnaires showed improvements in both physical and functional well being among the participants taking the supplement ... Bothersome symptoms such as lack of energy, pain, nausea, and sleeplessness were all improved, as were measures of functional well-being, for example the ability to perform normal activities at home or work. Simply, they reported a greater enjoyment of life, without any additional side effects from the supplement ... ArginMaxTM is made from a patented formula containing a proprietary blend of L-arginine, ginseng, ginkgo, and 14 vitamins and minerals noted for boosting energy and circulation and optimizing hormonal balance. A separate Men's formula also is available" - See ArginMax products at Amazon.com.
  • Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression - Int J Cancer. 2011 Feb 3 - "Ninety percent of cancer-mediated deaths are due to metastasis of the tumor; however, the mechanisms controlling metastasis remain poorly understood. Thus, no therapy targeting this process has yet been approved. Chemokines and their receptors are mediators of chronic inflammation and have been linked to the metastasis of numerous cancers. More recently, the Cysteine X Cysteine (CXC) chemokine receptor 4 (CXCR4) has emerged as a key mediator of tumor metastasis; therefore, identification of inhibitors of this receptor has the potential to abrogate metastasis. In this report, we demonstrate that acetyl-11-keto-β-boswellic acid (AKBA), a component of the therapeutic plant Boswellia serrata, can downregulate CXCR4 expression in pancreatic cancer cells. The reduction in CXCR4 induced by this terpenoid was found to be cell-type specific, as its expression was also abrogated in leukemia, myeloma and breast cancer cell lines. Neither proteasome inhibitors nor lysosomal stabilization could prevent the AKBA-induced reduction in CXCR4 expression. This downregulation occurred at the transcriptional level. Suppression of CXCR4 by AKBA was accompanied by the inhibition of pancreatic cancer cell invasion, which is induced by CXCL12, the ligand for CXCR4. In addition, abrogation of the expression of chemokine receptor by AKBA was found in human pancreatic tissues from orthotopic animal model. AKBA also abolished breast tumor cell invasion, and this effect correlated with the disappearance of both the CXCR4 messenger RNA and CXCR4 protein. Overall, our results show that AKBA is a novel inhibitor of CXCR4 expression and, thus, has the potential to suppress the invasion and metastasis of cancer cells" - See boswellia at Amazon.com
  • Does selenium prevent cancer? It may depend on which form people take - Science Daily, 3/16/11 - "Hugh Harris and colleagues note that although the Nutritional Prevention of Cancer clinical trial showed that selenium reduced the risk of cancer, a later study called the Selenium and Vitamin E Cancer Prevention Trial did not show a benefit. A major difference between the trials was the form of selenium that was used. To find out whether different types of selenium have different chemopreventive properties, the researchers studied how two forms -- SeMet and MeSeCys -- are processed in human lung cancer cells ... The researchers found that MeSeCys killed more lung cancer cells than SeMet did. Also, lung cancer cells treated with MeSeCys processed the selenium differently than than cells treated with SeMet"
  • Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia - Cancer Lett. 2011 Mar 10 - "Cachexia, also known as wasting syndrome notably with skeletal muscle atrophy, costs nearly one-third of all cancer deaths in man. (-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenolic component in green tea, is a potent preventive against cachexia as well as cancers ... EGCG was demonstrated to be able to retard tumor progression as well as to prevent body weight from loss, because EGCG attenuates skeletal muscle leukocytic infiltration and down-regulates tumor-induced NF-κB and E3-ligases in muscle. In mice, the dosages optimized against cachexia were determined to be 0.2mg/mouse/day for prevention and to be 0.6mg/mouse/day for treatment. Anti-cachexia effects were assessed using the LLC tumor model. Mice with the same body weight were divided into groups, including control, tumor bearing, and tumor-bearing but receiving water or EGCG in both prevention and treatment experiments. RT-PCR was used to assess mRNA expressions of NF-κB, MuRF 1, and MAFbx. The intracellular NF-κB, MuRF 1 and MAFbx were determined and quantified by immunofluorescence and Western blotting, respectively. Our results conclude EGCG regulates the expressions of NF-κB as well as downstream mediators, MuRF 1 and MAFbx, so EGCG may be an appropriate agent to be included in ensemble therapeutics of the tumor-induced muscle atrophy" - See green tea extract at Amazon.com.
  • The Effect of Green Tea Extract and EGCG on the Signaling Network in Squamous Cell Carcinoma - Nutr Cancer. 2011 Mar 3:1 - "These results suggested that GTE and EGCG target multiple pathways or global networks in cancer cells, which resulted in collective inhibition of cancer cell growth" - See green tea extract at Amazon.com.
  • Markedly higher vitamin D intake needed to reduce cancer risk, researchers say - Science Daily, 2/22/11 - "We found that daily intakes of vitamin D by adults in the range of 4000-8000 IU are needed to maintain blood levels of vitamin D metabolites in the range needed to reduce by about half the risk of several diseases -- breast cancer, colon cancer, multiple sclerosis, and type 1 diabetes ... Most scientists who are actively working with vitamin D now believe that 40 to 60 ng/ml is the appropriate target concentration of 25-vitamin D in the blood for preventing the major vitamin D-deficiency related diseases ... only 10 percent of the US population has levels in this range, mainly people who work outdoors" - See vitamin D at Amazon.com.
  • Epigallocatechin Gallate (EGCG), a Major Component of Green Tea, is a Dual Phosphoinositide-3-kinase/mTOR Inhibitor - Biochem Biophys Res Commun. 2011 Feb 4 - "The PI3K signaling pathway is activated in a broad spectrum of human cancers, either directly by genetic mutation or indirectly via activation of receptor tyrosine kinases or inactivation of the PTEN tumor suppressor ... The potency of EGCG against PI3K and mTOR is within physiologically relevant concentrations. In addition, EGCG inhibits cell proliferation and AKT phosphorylation at Ser473 in MDA-MB-231 and A549 cells. Molecular docking studies show that EGCG binds well to the PI3K kinase domain active site, agreeing with the finding that EGCG competes for ATP binding. Our results suggest another important molecular mechanism for the anticancer activities of EGCG" - See green tea extract at Amazon.com.
  • The Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch Tumors - Nutr Cancer. 2011 Feb 2:1 - "Epidemiological studies have consistently demonstrated the protective effects of dietary phytochemicals against cancer risk. Quercetin, a ubiquitous dietary flavonoid, has attracted considerable attention owing to its potent antioxidant and antiproliferative activities ... Simultaneous administration of quercetin to DMBA-painted hamsters reduced tumor incidence and tumor burden, while posttreatment of quercetin resulted in a significant tumor growth delay. In addition, quercetin administration induced cell cycle arrest and apoptosis and blocked invasion and angiogenesis. We found a positive correlation between the inhibition of HDAC-1 and DNMT1 by quercetin and its anticancer properties. A dietary phytochemical such as quercetin that modulates a plethora of molecules offers promise as an ideal candidate for multitargeted cancer prevention and therapy" - See quercetin at Amazon.com.
  • Protective properties of green tea uncovered - Science Daily, 1/5/11 - "Regularly drinking green tea could protect the brain against developing Alzheimer's and other forms of dementia ... The study, published in the academic journal Phytomedicine, also suggests this ancient Chinese remedy could play a vital role in protecting the body against cancer" - See green tea extract at Amazon.com.
  • A Heat-Stable Extract From Mucuna Stimulates the Differentiation of Bone Marrow Cells Into Dendritic Cells and Induces Apoptosis in Cancer Cells - Nutr Cancer. 2010 Dec 16:1 - "Pine cone extract is known to induce differentiation of human mononuclear cells into dendritic cells (DCs) and also to induce apoptosis in human cancer cells. In the present study, we screened edible plants that contain components with biological activities similar to or more potent than those of pine cone extract. We found that Mucuna (Mucuna pruviens var. utilis) contains a DC differentiation/maturation-inducing activity and a component that induces apoptosis in human cancer cell lines. Mucuna extract specifically stimulated differentiation of BM cells to immature DCs. Marked production of IL-6 was observed by sequential treatment with at least 10 μg/mL of Mucuna extract followed by LPS. The sequential treatment with Mucuna extract followed by LPS produced a much higher ratio of IL-12 to IL-6 and a lower ratio of TNF-α to IL-6 than that obtained by sequential treatment with a medicinal mushroom Phellinus linteus extract and then LPS. The DC differentiation/maturation activity and the component inducing apoptosis in cancer cells were separable by column chromatography" - See Mucuna pruriens at Amazon.com.
    • Dendritic cell - Wikipedia - "Dendritic cells (DCs) are immune cells that form part of the mammalian immune system. Their main function is to process antigen material and present it on the surface to other cells of the immune system, thus functioning as antigen-presenting cells. They act as messengers between the innate and adaptive immunity"
  • Aspirin Cuts Death Rate From Several Common Cancers - Medscape, 12/7/10 - "The researchers showed a 21% reduction in the number of deaths caused by cancer among those who had taken aspirin, compared with those who had not ... The investigation also showed that the benefits of taking aspirin increased over time. After 5 years, death rates were shown to fall by 34% for all cancers and by 54% for gastrointestinal cancers ... This 20-year follow-up established that the risk for cancer death remained 20% lower among those who had been allocated aspirin than among those who had not for all solid cancers, including lung, prostate, brain, bladder, and kidney cancers, and by 35% for gastrointestinal cancers ... The fall in the risk for death broke down according to individual types of cancer: 60% for esophageal cancer, 40% for colorectal cancer, 30% for lung cancer, and 10% for prostate cancer" - Note:  There are also downsides to aspirin.  Some examples:
    • Regular analgesic use increases hearing loss in men, study finds - Science Daily, 3/1/10 - "For aspirin, regular users under 50 and those aged 50-59 years were 33% more likely to have hearing loss than were nonregular users, but there was no association among men aged 60 years and older. For NSAIDs, regular users aged under 50 were 61% more likely, those aged 50-59 were 32% more likely, and those aged 60 and older were 16% more likely to develop hearing loss than nonregular users of NSAIDs. For acetaminophen, regular users aged under 50 were 99% more likely, regular users aged 50-59 were 38% more likely, and those aged 60 and older were 16% more likely to have hearing loss than nonregular users of acetaminophen"
    • Regular use of aspirin increases risk of Crohn's disease by 5 times, study finds - Science Daily, 5/4/10 - "the researchers discovered that those taking aspirin regularly for a year or more were around five times more likely to develop Crohn's disease"
  • Influence of diet enriched with Conjugated Linoleic Acids on their distribution in tissues of rats with DMBA induced tumors - Lipids Health Dis. 2010 Nov 2;9(1):126 - "Animals were divided into four groups depending on the diet supplementation (oil or Bio-C.L.A. (Pharma Nord Denmark) given intragastrically) and presence or absence of carcinogenic agent (7,12-dimethylbenz[a]antharcene) ... Diet enriched with CLA decreased the cancer morbidity (67% in Bio-C.L.A. compared to 88% in oil) and delayed the cancer induction" - See conjugated linoleic acid at Amazon.com.
  • Flavonoids, proanthocyanidins, and cancer risk: a network of case-control studies from Italy - Nutr Cancer. 2010 Oct;62(7):871-7 - "Total flavonoids, flavanones, and flavonols were inversely related to oral and laryngeal cancers (ORs, respectively 0.56 and 0.60 for total flavonoids; 0.51 and 0.60 for flavanones; and 0.62 and 0.32 for flavonols). Flavanols were also inversely related to laryngeal cancer (OR = 0.64), whereas flavanones were inversely related to esophageal cancer (OR = 0.38). A reduced risk of colorectal cancer was found for high intake of anthocyanidins (OR = 0.67), flavonols (OR = 0.64), flavones (OR = 0.78), and isoflavones (OR = 0.76). Inverse relations with breast cancer were found for flavones (OR = 0.81) and flavonols (OR = 0.80). Flavonols (OR = 0.63) and isoflavones (OR = 0.51) were inversely associated to ovarian cancer, whereas flavonols (OR = 0.69) and flavones (OR = 0.68) were inversely associated to renal cancer. No association between flavonoids and prostate cancer emerged. We found inverse associations between proanthocyanidins and colorectal cancer. These associations appeared stronger for proanthocyanidins with a higher degree of polymerization (OR = 0.69 for ≥ 10 mers)" - See bioflavonoids at Amazon.com.
  • Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival - Am J Clin Nutr. 2010 Sep 29 - "Plasma arginine concentrations are lower in patients with cancer, which indicates that arginine metabolism may be disturbed in these patients. Arginine supplementation has been associated with positive effects on antitumor mechanisms and has been shown to reduce tumor growth and to prolong survival. Furthermore, the prognosis of patients with head and neck cancer remains disappointing. Insufficient intake frequently leads to malnutrition, which contributes to high morbidity and mortality rates ... The group receiving arginine-enriched nutrition had a significantly better overall survival (P = 0.019) and better disease-specific survival (P = 0.022). Furthermore, the arginine-supplemented group had a significantly better locoregional recurrence-free survival (P = 0.027). No significant difference in the occurrence of distant metastases or occurrence of a second primary tumor was observed between the groups" - See L-arginine products at Amazon.com.
  • Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Chronic inflammation plays pivotal roles in both cancer and cardiovascular diseases. A large body of evidence suggests that high intake of cruciferous vegetables is closely related with low risk of these disorders ... Taken all together, adhesion molecules are confirmed to be the novel targets of sulphoraphane in preventing inflammatory insult to endothelial cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the subsequent expression of adhesion molecules. These data suggested a novel inflammatory pathway mediated by sulphoraphane" - See sulforaphane at Amazon.com.
  • Curcuminoids Suppress the Growth and Induce Apoptosis through Caspase-3-Dependent Pathways in Glioblastoma Multiforme (GBM) 8401 Cells - J Agric Food Chem. 2010 Sep 7 - "The results observed with proliferation inhibition (y = 94.694e(-0.025x), R(2) = 0.9901, and n = 6) and apoptosis (y = 0.9789e(-0.0102x), R(2) = 0.99854, and n = 3) depend upon the amount of curcuminoid treatment in the cancer cells" - See curcumin products at Amazon.com.
  • Metformin Might Prevent Colorectal, Lung Cancers - Medscape, 9/3/10 - "The chance observation that diabetes patients taking metformin have a 40% reduced risk for cancer triggered intense research interest in this old off-patent drug ... After about 10% of the mouse lifespan — about 12 weeks — with the highest dose in the drinking water, we found a 33% reduction in tumor multiplicity and a 34% reduction in tumor size in the mice. In mice that did not get metformin, 100% got tobacco carcinogen-induced lung tumors ... metformin might prevent tumors by reducing levels of insulin and IGF-1" - See my Insulin and Aging page.  There are a lot of studies pointing toward insulin being a major cause of aging and caner.  See metformin at The Antiaging Store.
  • {gamma}-Tocotrienol but not {gamma}-tocopherol blocks STAT3 cell signaling pathway through induction of protein tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents - J Biol Chem. 2010 Aug 18 - "We found that gamma-T3 but not gamma-tocopherol, the most common saturated form of Vitamin E, inhibited constitutive activation of STAT3 in a dose- and time-dependent manner and this inhibition was not cell type specific. gamma-T3 also inhibited STAT3 DNA binding ... This vitamin also sensitized the tumor cells to the apoptotic effects of thalidomide and bortezomib. Overall, our results suggest that gamma-T3 is a novel blocker of STAT3 activation pathway in both in vitro and in vivo and thus may have potential in prevention and treatment of cancers" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death - Cancer Lett. 2010 Jul 26 - "NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These findings indicate that the combination of Cu(II) and thiols generates cytotoxic ROS that induce apoptosis in cancer cells. They also indicate a fourth class of anti-neoplastic metal-binding compounds, the "ROS generators"" - See n-acetyl cysteine at Amazon.com.
  • Cutting fat and calories can lower cancer risk in dogs and people - Science Daily, 7/22/10 - "As many as 1 out of 3 cancer deaths in both humans and dogs could be prevented by reducing Omega-6 fatty acids and cutting calories ... Omega-6, such as corn oil, vegetable oil and grain-fed red meat. Too much Omega-6 fatty acid can lead to inflammation, which creates an environment conducive to cancer in dogs and people ... obesity in both dogs and humans limits the production of adiponectin, a hormone that has been shown to inhibit cancer cell growth. He recommended reducing calories, particularly those from sugar, which has the additional danger of not only causing obesity, but also feeding cancer cells and encouraging their growth ... the ideal blend of fiber for dog food is about 75 to 80 percent insoluble and 20 to 25 percent soluble. In addition, adding quality prebiotics to pet foods can enhance their gut health"
  • Short Telomeres Tied to Cancer Risk - Medscape, 7/9/10 - "short telomere length was associated with a 60% increased risk for subsequent cancer"
  • HDL Cholesterol and Cancer - Medscape, 6/15/10 - "even after adjustment for multiple variables, there was a 36% lower risk of cancer for every 10-mg/dL increase in HDL cholesterol" - See niacin at Amazon.com.
  • Researchers fishing for cancer cure discover active DHA derivatives - Science Daily, 3/1/10 - "Results showed that DHA killed the cancer cells, but that the toxic derivatives produced by DHA were even more effective at killing the cancer cells. This suggests that DHA could become a new agent for treating neuroblastoma and possibly many other cancers" - See Jarrow Max DHA at Amazon.com.
  • Improved Survival in Patients with End-stage Cancer Treated with Coenzyme Q(10) and Other Antioxidants: a Pilot Study - J Int Med Res. 2009;37(6):1961-1971 - "This pilot study evaluated the survival of patients with end-stage cancer who received supplements of coenzyme Q(10) and a mixture of other antioxidants (e.g. vitamin C, selenium, folic acid and beta-carotene) ... Median predicted survival was 12 months (range 3 - 29 months), whereas median actual survival was 17 months (1 - 120 months), which is > 40% longer than the median predicted survival. Mean actual survival was 28.8 months versus 11.9 months for mean predicted survival. Ten patients (24%) survived for less time than predicted, whereas 31 (76%) survived for longer. Treatments were very well tolerated with few adverse effects" - See ubiquinol products at Amazon.com.
  • The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells - Nutr Cancer. 2010;62(1):116-21 - "We first confirmed and extended the results of others showing that the inhibitory action of CLA on proliferation is dependent on the cell type as well as the structure of the isomer, the 10,12 isomer being a more potent inhibitor than the 9,11 isomer in the concentration range 25-100 microM. By Western analysis, we showed that 10,12 CLA downregulated FAS expression in all of the cell lines in a concentration-dependent manner, but the 9,11 isomer had no effect. Both isomers inhibited FAS enzyme activity, but 10,12 CLA was again more potent than the 9,11 isomer. Our results suggest that downregulation of FAS by 10,12 CLA, but not by the 9,11 isomer, as well as inhibition of FAS enzyme activity by both isomers, may contribute to growth inhibition of cancer cells but only at relatively high concentrations" - Note:  I wish they would state brand names instead of leaving the reader with trying to figure which brand correlates with which isomers.  See conjugated linoleic acid at Amazon.com.
  • Vitamin D Supplementation and Cancer Prevention - Medscape, 12/8/09 - "The relative risk for the development of cancer at the study's end was 0.402 for the calcium plus vitamin D group (P = .013) and 0.532 for the calcium-only group (P = .063) ... This translated to a predicted 35% reduced risk of cancer for every 25-nmol/L (10-ng/mL) increase in serum 25-hydroxyvitamin D. The authors concluded that improving vitamin D nutritional status substantially reduced all-cancer risk in postmenopausal women and that baseline and treatment-induced serum 25-hydroxyvitamin D concentrations were strong predictors of cancer risk" - See vitamin D at Amazon.com.
  • Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 - "Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases" - See resveratrol products at Amazon.com.
  • Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of gamma-Interferon-Induced JAK-PKC-delta-STAT1 Signaling in Human Oral Cancer Cells - J Agric Food Chem. 2009 Nov 24 - "In this study, (-)-epigallocatechin-3-gallate (EGCG), the major constituent of green tea, is found to significantly inhibit the expression of IDO in human oral cancer cell lines ... This study indicates that EGCG is a potential drug for immune and target therapy to enhance cancer therapy by increasing antitumor immunity" - See green tea extract at Amazon.com.
  • HDL Cholesterol Inversely Associated With Cancer Risk - Doctor's Guide, 11/16/09 - "The investigators found a significant inverse relationship between baseline HDL-C levels and the rate of incident cancer, reporting that every 10 mg/dL increase in HDL-C was associated with a 24% (95% CI: 1%-41%) relative reduction in the cancer rate ... They also found a significant inverse relationship between baseline LDL-C and the rate of incident cancer, with every 10-mg/dL reduction in LDL-C associated with a 14% (95% CI: 9%-18%) relative increase in the cancer rate ... There was a significant direct relationship between both age and BMI and rate of incident cancer, with every 5-year increase in age associated with a 28% (95% CI: 16%-42%) relative increase in cancer (P < .001) and every 1-kg/m2 increase in BMI associated with an 18% (95% CI: 6%-31%) relative increase in the cancer rate"
  • Link Between Alcohol And Cancer Explained: Alcohol Activates Cellular Changes That Make Tumor Cells Spread - Science Daily, 10/26/09
  • Diabetes Drug Fights Breast Cancer - WebMD, 9/14/09 - "And in mice carrying human breast cancers, metformin made standard chemotherapy vastly more effective. Mice treated with the combination remain cancer-free for four months, unlike mice treated with either drug alone ... A lot of data shows lower cancer risk -- not just breast cancer -- in people taking metformin for diabetes ... This drug at low doses can be considered a very good candidate for cancer prevention before a person has any cancer at all" - Note:  I've been taking metformin for years for anti-aging.  See my Insulin and Aging page.  See metformin at IAS.
  • Natural Compounds, Chemotherapeutic Drugs May Become Partners In Cancer Therapy - Science Daily, 9/7/09 - "New research shows that chlorophyllin -- a water-soluble derivative of chlorophyll, the green pigment found in most plants -- may be 10 times more potent at killing colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancer treatment" - See chlorophyllin at Amazon.com.
  • Red-wine Polyphenol Called Resveratrol Demonstrates Significant Health Benefits - Science Daily, 6/11/09 - "The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more ... Resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection ... The simplest explanation is that resveratrol turns on the cell's own survival pathways, preventing damage to individual cells ... Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells ... Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death" - See resveratrol products at Amazon.com.
  • New Model Of Cancer Development: Low Vitamin D Levels May Have Role - Science Daily, 5/22/09 - "previous theories linking vitamin D to certain cancers have been tested and confirmed in more than 200 epidemiological studies, and understanding of its physiological basis stems from more than 2,500 laboratory studies ... Vitamin D may halt the first stage of the cancer process by re-establishing intercellular junctions in malignancies having an intact vitamin D receptor ... Vitamin D levels can be increased by modest supplementation with vitamin D3 in the range of 2000 IU/day" - See vitamin D at Amazon.com.
  • Naturally Occurring Compounds Selectively Deplete Mutant P53 In Tumor Cells - Science Daily, 4/20/09 - "This study demonstrates for the first time that phenethyl isothiocyante (PEITC), a naturally-occurring compound, can selectively deplete mutant p53. The authors also made an intriguing observation that the depletion of mutant p53 in human cancer cells is accompanied by restoration of the wild type p53. PEITC is a member of the isothiocyanate family compounds found in cruciferous vegetables, such as watercress, broccoli and cabbage. PEITC has been shown to have cancer preventive activity"
  • Omega-3 Kills Cancer Cells - Science Daily, 4/1/09 - "Docosahexanoic acid (DHA), an omega-3 fatty acid found in fish oils, has been shown to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects ... at the molecular level, DHA acts by reducing leukocytosis (white blood cell accumulation), systemic inflammation, and oxidative stress – all processes that have been linked with tumour growth" - See Jarrow Max DHA at Amazon.com.
  • Health Benefits, Consequences Of Folic Acid Dependent On Circumstances - Science Daily, 4/1/09 - "Under most circumstances, adequate intake of folate appears to assume the role of a protective agent against cancer, most notably colorectal cancer. However, in select circumstances in which an individual who harbors a pre-cancerous or cancerous tumor consumes too much folic acid, the additional amounts of folate may instead facilitate the promotion of cancer"
  • Tocotrienol build-up in tumours ‘critical’ for anti-cancer benefits: Study - Nutra USA, 3/31/09 - "the effects of gamma- and delta-tocotrienol on mouse cancer cells ... the diet supplemented with 0.1 per cent gamma-tocotrienol or 0.1 per cent delta-tocotrienol for four weeks ... In conclusion, our results suggested that accumulation is critical for the anti-tumour activity of tocotrienols" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.  Note:  If gamma-tocotrienol is critical for preventing cancer and alpha vitamin E (the form found nearly always in supplements) reduces the gamma, it seems like alpha vitamin E would increase cancer risks. See:
  • Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo - J Nutr Biochem. 2008 Sep 26 - "In C3H/HeN mice implanted with MH134, it was found that gamma-T3 and delta-T3 feeding significantly delayed tumor growth ... Intriguingly, we found that T3 was detected in tumor, but not in normal tissues. These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression - Lipids Health Dis. 2009 Mar 17;8(1):8 - "Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both in vitro and in vivo conditions ... Combination therapy using drugs with other, complementary targets and GLA could lead to gains in treatment efficacy in this notoriously difficult to treat tumour" - See borage oil at Amazon.com.
  • Support For Adjunctive Vitamin C Treatment In Cancer - Science Daily, 3/5/09 - "Challem points out two main problems with the study: the oxidized form of vitamin C (dehydroascorbic acid) and not actual vitamin C (ascorbic acid) was used; and in the mouse experiments, the animals were given toxic doses of dehydroascorbic acid, a compound that is not used as a dietary supplement in humans ... This study and the subsequent headlines [it generated] were a grievous disservice to physicians and patients with cancer ... considerable positive research…has shown striking benefits from high-dose vitamin C (ascorbic acid) in cancer cells and animals—and in actual human beings"
  • 1 in 3 Common Cancers May Be Preventable - WebMD, 2/26/09 - "eating a nutritious diet, being physically active, and keeping body fat under control may prevent: ... 38% of breast cancers ... 45% of colorectal cancers ... 36% of lung cancers ... 39% of pancreatic cancers ... 47% of stomach cancers ... 69% of esophageal cancers ... 63% of cancers of the mouth, pharynx, or larynx ... 70% of endometrial cancers ... 24% of kidney cancers ... 21% of gallbladder cancers ... 15% of liver cancers ... 11% of prostate cancers"
  • Excessive Dietary Fat Caused 300 Percent Increase in Metastasizing Tumor Cells In Animal Models - Science Daily, 2/25/09 - "Researchers at Purdue University have precisely measured the impact of a high-fat diet on the spread of cancer, finding that excessive dietary fat caused a 300 percent increase in metastasizing tumor cells in laboratory animals"
  • Blueberries May Shrink Tumors in Babies - WebMD, 1/21/09 - "Mice with blood vessel tumors that were fed the blueberry extract lived twice as long as mice that did not get the substance and had tumors 60% smaller than mice that did not receive blueberry extract treatment ... Oral administration of blueberry extract represents a potential therapeutic strategy for treating endothelial cell tumors in children" - See blueberry extracts at Amazon.com.
  • Broccoli Compound Targets Key Enzyme In Late-stage Cancer - Science Daily, 12/14/08 - "The new findings are the first to explain how indole-3-carbinol (I3C) stops cell growth, and thus provides the basis for designing improved versions of the chemical that would be more effective as a drug and could work against a broader range of breast as well as prostate tumors ... I3C inhibits the enzyme elastase, which at high levels in breast cancer cells heralds a poor prognosis: decreased response to chemotherapy, reduced response to endocrine treatment and reduced survival rates" - See indole 3 carbinol at Amazon.com.
    Physical Activity, Sleep May Cut Cancer Risk - WebMD, 11/17/08 - "Among the most physically active women younger than 65 -- women who reported getting about an hour a day of moderate physical activity -- cancer was 47% rarer for those who got at least seven hours of nightly sleep. Those findings held regardless of other cancer risk factors"
  • Pectin Power: Why Fruits And Vegetables May Protect Against Cancer's Spread - Science Daily, 10/13/08 - "They have shown that a fragment released from pectin, found in all fruits and vegetables, binds to and is believed to inhibit galectin 3 (Gal3), a protein that plays a role in all stages of cancer progression" - See pectin supplements at Amazon.com.
  • Unpopular veggies vital for cancer protection: Study - Nutra USA, 10/7/08 - "Significant inhibition of all the cancer cell lines tested – stomach, lung, breast, kidney, skin, pancreas, prostate, and brain – was observed for all the extracts from cruciferous vegetables, such as broccoli, kale, Brussels sprouts, and curly cabbage, and vegetables of the genus Allium, such as garlic ... These chemopreventive effects are likely related to the formation of organosulfur compounds following mechanical disruption of these vegetables, namely isothiocyanates from cruciferous and a series of allyl sulfur molecules from Allium vegetables"
  • Coffee consumption and the risk of cancer: An overview - Cancer Lett. 2008 Sep 30 - "Habitual coffee drinking has been associated with a reduced risk of mortality and chronic diseases, including cancer. The favourable influence of coffee is supported by several plausible mechanisms due to the presence of a variety of biological compounds such as caffeine, diterpenes, caffeic acid, polyphenols as well as volatile aroma and heterocyclic substances. Current evidence suggests that coffee consumption is associated with a reduced risk of liver, kidney, and to a lesser extent, premenopausal breast and colorectal cancers, while it is unrelated to prostate, pancreas and ovary cancers. Coffee drinking may still help reduce death due to liver cancer"
  • Black Raspberries Slow Cancer By Altering Hundreds Of Genes - Science Daily, 8/27/08 - "examined the effect of freeze-dried black raspberries on genes altered by a chemical carcinogen in an animal model of esophageal cancer ... The carcinogen affected the activity of some 2,200 genes in the animals’ esophagus in only one week, but 460 of those genes were restored to normal activity in animals that consumed freeze-dried black raspberry powder as part of their diet during the exposure"
  • Mushroom extract demonstrates immunity benefits - Nutra USA, 8/25/08 - "measured the production of two cytokines – Interferon (IFN-y) and Tumor Necrosis Factor (TNF-a) – for 30 and 60 days ... These cytokines are produced by white blood cells and used by the body to prevent the growth of abnormal and cancerous cells ... the production of IFN-y and TNF-a increased within four weeks of taking the recommended of AHCC and continued to boost the immune system for at least four weeks after AHCC consumption stopped" - See AHCC at Amazon.com.
  • Dietary Supplement Use in Cancer Care: Help or Harm (.pdf) - Hematol Oncol Clin North Am. 2008 Aug 1;22(4):581-617 - "Immune Modulation ..."
  • Vitamin C Injections Slow Tumor Growth In Mice - Science Daily, 8/4/08 - "high concentrations of ascorbate had anticancer effects in 75 percent of cancer cell lines tested, while sparing normal cells. In their paper, the researchers also showed that these high ascorbate concentrations could be achieved in people" - Note:  I was taking about 8 grams of vitamin C per day when I had neck cancer.  Maybe that's what saved me.
  • Magnolia Compound Hits Elusive Target In Cancer Cells - Science Daily, 7/11/08 - "A natural compound from magnolia cones blocks a pathway for cancer growth that was previously considered "undruggable," ... has been studying the compound honokiol ... We found that it is particularly potent against tumors with activated Ras" - See honokiol at Amazon.com.
  • Chinese Red Yeast Rice Is Good For Your Heart, Study Suggests - Science Daily, 6/9/08 - "a partially purified extract of Chinese red yeast rice, Xuezhikang (XZK), reduced the risk of repeat heart attacks by 45%, revascularization (bypass surgery/angioplasty), cardiovascular mortality and total mortality by one-third and cancer mortality by two-thirds" - See red yeast rice at Amazon.com.
  • Exercise Cuts Cancer Death In Men - Science Daily, 5/29/08 - "Men who walked or cycled for at least 30 minutes a day had an increased survival from cancer with 33 per cent, than the men who exercised less or did nothing at all ... a more extensive programme of walking and cycling for between 60 and 90 minutes and a day, led to a l6 per cent lower incidence of cancer. But these activities only led to a five per cent reduction in cancer rates among the men who walked or cycled for 30 minutes day, a finding which could be due to chance"
  • To Block The Carcinogens, Add A Touch Of Rosemary When Grilling Meats - Science Daily, 5/21/08 - "Rosemary, a member of the mint family and a popular seasoning on its own, also has benefits as a cancer prevention agent. Apply it to hamburgers and it can break up the potentially cancer-causing compounds that can form when the meat is cooked ... Rosemary’s antioxidant content makes this method possible thanks to the presence of phenolic compounds. Those compounds – rosmarinic acid, carnosol and carnosic acid – block the HCAs before they can form during heating"
  • Dietary flavonoid intake and risk of cancer in postmenopausal women: The Iowa Women's Health Study - Int J Cancer. 2008 May 19 - "After multivariable adjustment, lung cancer incidence was inversely associated with intakes of flavanones (HR = 0.68; 95% CI: 0.53-0.86, all results highest vs. lowest quintile) and proanthocyanidins (HR = 0.75; 95% CI: 0.57-0.97). Among current and past smokers, those with intakes in the highest quintile for flavanones (HR = 0.66; 95% CI: 0.50-0.86), and proanthocyanidins (HR = 0.66; 95% CI; 0.49-0.89) had significantly lower lung cancer incidence than those in the lowest quintile. Similar associations were not seen in never smokers. Isoflavone intake was inversely associated with overall cancer incidence (HR = 0.93, 95% CI: 0.86-1.00). This study provides further support for a beneficial effect of flavonoid intake on lung cancer risk, especially among current and past smokers" - See bioflavonoids at Amazon.com.
  • Vitamin D and cancer: maintaining levels key to protection? - Nutra USA, 5/12/08 - "After adjusting for various potential confounding factors, the researchers report that people with the highest level of 25(OH)D (76.3 nanomoles per litre) were 55 per cent less likely to die form fatal cancer than those with the lowest levels (18.1 nmol/L)" - [Abstract] - See vitamin D at Amazon.com.
  • Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography - Cancer Epidemiol Biomarkers Prev. 2008 May 7 - "After adjustment for possible confounders, the Cox proportional hazard ratio (95% confidence interval) of the fourth 25(OH)D quartile was 0.45 (0.22-0.93) when compared with the first quartile and the hazard ratio per increase of 25 nmol/L in serum 25(OH)D concentrations was 0.66 (0.49-0.89)" - See vitamin D at Amazon.com.
  • Curcumin and cancer: An "old-age" disease with an "age-old" solution - Cancer Lett. 2008 May 5 - "The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus an "old-age" disease such as cancer requires an "age-old" treatment" - See curcumin products at Amazon.com.
  • Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography - Cancer Epidemiol Biomarkers Prev. 2008 May 7 - "our data suggest that low levels of 25(OH)D are associated with increased risk of fatal cancer in patients referred to coronary angiography and that the maintenance of a sufficient vitamin D status might therefore be a promising approach for the prevention and/or treatment of cancer" - See vitamin D at Amazon.com.
  • Multi-targeted prevention and therapy of cancer by proanthocyanidins - Cancer Lett. 2008 May 3 - "A wide variety of botanicals, mostly dietary flavonoids or polyphenolic substances, have been reported to possess substantial anti-carcinogenic and antimutagenic activities because of their antioxidant and anti-inflammatory properties. Proanthocyanidins are considered as one of them, and are abundantly available in various parts of the plants, such as fruits, berries, bark and seeds. Their modes of action were evaluated through a number of in vitro and in vivo studies which showed their potential role as anti-carcinogenic agent. We summarize and highlight the latest developments on anti-carcinogenic activities of proanthocyanidins from different sources, specifically from grape seeds, and their molecular targets, such as NF-kappaB, mitogen-activated protein kinases, PI3K/Akt, caspases, cytokines, angiogenesis and cell cycle regulatory proteins and other check points, etc. Although the bioavailability and metabolism data on proanthocyanidins is still largely unavailable, certain reports indicate that at least monomers and smaller oligomeric procyanidins are absorbed in the gut. The modulation of various molecular targets by proanthocyanidins in vitro and in vivo tumor models suggests their importance, contribution and mechanism of action to the prevention of cancers of different organs" - See grape seed extract at Amazon.com and Pycnogenol at Amazon.comSome say the grape seed extract if the same as Pycnogenol without the patent markup.
  • Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 - "Overall, women who engaged in recreational exercise 30 to 150 minutes per week were 50% less likely to have breast cancer than women who exercised less than a half hour per week ... People who ate quercetin-rich foods at least four times a week, on average, were 51% less likely to have lung cancer than those who ate none"
  • Extracts From Reishi Mushroom And Green Tea Shows Synergistic Effect To Slow Sarcoma - Science Daily, 4/8/08 - "Both the reishi mushroom (Ganoderma lucidum; Lingzhi) and green tea have long held a place in traditional medicine in China and other Asian countries, for the general promotion of health and long life and for the treatment of specific diseases. More recent scientific studies have confirmed that both enhance the body¹s immune functions and hold the potential for treatment and prevention of many types of cancer" - See reishi at Amazon.com and green tea extract at Amazon.com.
  • Dehydroascorbic acid as an anti-cancer agent - Cancer Lett. 2008 Mar 28 - "dehydroascorbic acid has the remarkable ability to eliminate the aggressive mouse tumours, L1210, P388, Krebs sarcoma, and Ehrlich carcinoma"
    • Dehydroascorbic acid - Wikipedia - "Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid"
  • Mounting Evidence Shows Red Wine Antioxidant Kills Cancer - Science Daily, 3/25/08 - "Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function ... The new study also showed that when the pancreatic cancer cells were doubly assaulted -- pre-treated with the antioxidant, resveratrol, and irradiated -- the combination induced a type of cell death called apoptosis, an important goal of cancer therapy" - [WebMD] - See resveratrol products at Amazon.com.
  • Indole-3-carbinol as a chemopreventive and anti-cancer agent - Cancer Lett. 2008 Feb 29 - "Indole-3-carbinol and its metabolite 3,3'-diindoylmethane (DIM) target multiple aspects of cancer cell-cycle regulation and survival including Akt-NFkappaB signaling, caspase activation, cyclin-dependent kinase activities, estrogen metabolism, estrogen receptor signaling, endoplasmic reticulum stress, and BRCA gene expression. This broad spectrum of anti-tumor activities in conjunction with low toxicity underscores the translational value of indole-3-carbinol and its metabolites in cancer prevention/therapy. Furthermore, novel anti-tumor agents with overlapping underlying mechanisms have emerged via structural optimization of indole-3-carbinol and DIM, which may provide considerable therapeutic advantages over the parental compounds with respect to chemical stability and anti-tumor potency. Together, these agents might foster new strategies for cancer prevention and therapy" - See indole 3 carbinol at Amazon.com and diindolylmethane at Amazon.com.
  • beta-Sitosterol induces G(2)/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways - Cancer Lett. 2008 Feb 29 - "beta-Sitosterol (SITO) is a potentially valuable candidate for cancer chemotherapy ... results suggest that SITO induces endoreduplication by promoting spindle microtubule dynamics through the Bcl-2 and PI3K/Akt signaling pathways" - See beta sitosterol at Amazon.com.
  • Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults - Arch Intern Med. 2008 Feb 25;168(4):404-10 - "we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality"
  • A Ray Of Sunshine In The Fight Against Cancer: Vitamin D May Help - Science Daily, 2/13/08 - "It sounds too good to be true … a little inexpensive pill that could block the development of some cancers, strengthen bones, prevent multiple sclerosis and alleviate winter depression ... But it’s not science fiction. The “new aspirin” could be Vitamin D ... during the winter, Canadians take at least 1,000 units a day of Vitamin D" - See vitamin D at Amazon.com.
  • Sunlight: Good for Bad for Cancer Risk? - WebMD, 1/7/08 - "In populations with similar skin types, the incidence of all kinds of skin cancer increases from north to south, they found ... The incidence of internal cancers -- colon, lung, breast, and prostate -- also increased from north to south. But Setlow's team found that those who lived in southern latitudes -- and who made more vitamin D from sun exposure -- were much less likely to die from those cancers than were the northern latitude residents" - See vitamin D at Amazon.com.
  • Is There an Anticancer Diet? - WebMD, 12/6/07 - "Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and cauliflower seem to reduce bladder cancer risk by about 40%"
  • Chemoprevention, Naturally: Findings On Plant-derived Cancer Medicines - Science Daily, 12/6/07 - "rats fed a diet containing Polyphenon E, a standardized green tea polyphenol preparation, are less than half as likely to develop colon cancer ... After 34 weeks, rats that received Polyphenon E developed 55 percent fewer tumors compared to the control rats that did not receive Polyphenon E. Moreover, the tumors were 45 percent smaller in rats treated with green tea extract" - See green tea extract at Amazon.com.
  • Diet And Cancer Prevention: New Evidence For The Protective Effects Of Fruits And Veggies - Science Daily, 12/6/07
  • Night Shift Work May Cause Cancer - WebMD, 11/30/07 - "They note that shift work may raise cancer risk by suppressing production of melatonin, a chemical involved in the circadian rhythm" - See melatonin at Amazon.com.
  • Molecular basis of the potential of vitamin D to prevent cancer - Curr Med Res Opin. 2007 Nov 21 - "Research strongly supports the view that efforts to improve vitamin D status would have significant protective effects against the development of cancer. The clinical research community is currently revising recommendations for optimal serum levels and for sensible levels of sun exposure, to levels greater than previously thought. Currently, most experts in the field believe that intakes of between 1000 and 4000 IU will lead to a more healthy level of serum 25(OH)D, in the range of 75 nmol/L that will offer significant protect effects against cancers of the breast, colon, prostate, ovary, lungs, and pancreas. The first randomized trial has shown significant protection against breast cancer, and other clinical trials will follow and ultimately lead to improved public health policies and significantly fewer cancers" - See vitamin D at Amazon.com.
  • Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products - Nutr Cancer. 2007;57(1):78-87 - "Zyflamend inhibited receptor activator of NF-kappa B ligand-induced osteoclastogenesis, suppressed tumor necrosis factor (TNF)-induced invasion, and potentiated the cytotoxicity induced by TNF and chemotherapeutic agents, all of which are known to require NF-kappa B activation. Zyflamend suppressed NF-kappa B activation induced by both TNF and cigarette smoke condensate. The expression of NF-kappa B-regulated gene products involved in antiapoptosis (inhibitor-of-apoptosis protein 1/2, Bcl-2, Bcl-xL, FADD-like interleukin-1betaconverting enzyme/caspase-8 inhibitory protein, TNF receptor-associated factor-1, and survivin) and angiogenesis (vascular endothelial growth factor, cyclooxygenase-2, intercellular adhesion molecule, and matrix metalloproteinase-9) was also down-regulated by Zyflamend. This correlated with potentiation of cell death induced by TNF and chemotherapeutic agents. Overall, our results indicate that Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products" - See Zyflamend at Amazon.com.
  • Antioxidants Could Provide All-purpose Radiation Protection - Science Daily, 11/5/07 - "Inositol and inositol hexaphosphate (IP6) protected both human skin cells and a skin cancer-prone mouse from exposure to ultraviolet B (UVB) radiation, the damaging radiation found in sunlight ... Twenty-three percent of treated mice developed tumors, compared to 51 percent of untreated, or control mice, which developed tumors. Moreover, the mice in the treated group that did develop cancer had only half as many tumors as the control mice" - See IP-6 products at Amazon.com.  Note:  IP-6 was one of the supplements I took when they told me I only had a small chance of survival from neck cancer.  Click here for the full story.  I still take it.
  • Chemical In Red Wine, Fruits And Vegetables May Stop Cancer, Heart Disease, Depending On The Dose - Science Daily, 10/30/07 - "very high doses of antioxidant polyphenols shut down and prevent cancerous tumors by cutting off the formation of new blood vessels needed for tumor growth ... the same polyphenols play a beneficial role for those with diseased hearts and circulatory systems by facilitating blood vessel growth ... the amount of polyphenols necessary to obtain an anti-cancer effect is the equivalent of drinking about a bottle of red wine each day" - See grape seed extract at Amazon.com.
  • Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: Their inhibition by resveratrol - Cancer Lett. 2007 Oct 3 - "Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in various cellular events, including tumor invasion and metastasis ... Collectively, these results show that LPA under hypoxic condition enhances cell migration through the sequential induction of HIF-1alpha and VEGF, and that this enhancement is efficiently blocked by resveratrol" - See resveratrol products at Amazon.com.
  • How Vitamin C Stops Cancer - Science Daily, 9/10/07 - "Both of these cancers produce high levels of free radicals that can be suppressed by feeding the mice supplements of antioxidants, either vitamin C or N-acetylcysteine (NAC) ... Some rapidly growing tumors consume enough energy to easily suck out the available oxygen in their vicinity, making HIF-1 absolutely critical for their continued survival. But HIF-1 can only operate if it has a supply of free radicals. Antioxidants remove these free radicals and stop HIF-1, and the tumor, in its tracks" - See vitamin C products at Amazon.com.
  • Compound In Broccoli Could Boost Immune System, Says Study - Science Daily, 8/20/07 - "This study shows that there is a whole new universe of cancer regulation related to DIM ... There are virtually no other agents known that can both directly shut down the growth of cancer cells and enhance the function of the immune system at the same time" - See diindolylmethane at Amazon.com.
  • Coenzyme Q10 Summary - U. of Texas Alternative Medicine - See ubiquinol at Amazon.com.
  • Green Tea Boosts Production Of Detox Enzymes, Rendering Cancerous Chemicals Harmless - Science Daily, 8/10/07 - "In a study of 42 people, the concentrate -- composed of chemicals known as green tea catechins in amounts equal to that found in 8-16 cups of green tea -- boosted production of the enzymes, which belong to the glutathione S-transferase (GST) family, by as much as 80 percent in some participants ... GST enzymes are believed to be crucial to the body's defense against cancer-causing chemicals and other toxins, according to the study's lead investigator, H.-H. Sherry Chow, Ph.D., a research associate professor at the University of Arizona. They modify the cancer-causing molecules that would otherwise damage cellular DNA, thus rendering them inert" - See green tea extract at Amazon.com.  My favorite is green tea extract at Amazon.com.
  • Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial - Am J Clin Nutr. 2007 Jun;85(6):1586-91 - "Improving calcium and vitamin D nutritional status substantially reduces all-cancer risk in postmenopausal women"
  • Cancer Benefit From Vitamin D? - WebMD, 6/8/07 - "Women in the four-year study took 1,500 milligrams of calcium supplementation either alone or with 1,100 International Units (IU) of vitamin D each day ... women who took both supplements wound up with nearly 60% less risk of cancers at the end of the study compared with women who took placebo" - vitamin D at Amazon.com.
  • Can Aspirin Help Keep Cancer At Bay? - Science Daily, 4/16/07 - "those who said they regularly used aspirin had a 16 percent reduced risk of developing cancer more than a decade later, as well as a 13 percent reduced risk of dying from cancer over this same time period, compared to women who did not use aspirin. But there was no statistically significant impact on cancer incidence or mortality among women who used non-aspirin NSAIDs"
  • Broccoli, soy anti-cancer benefits suggested - Nutra USA, 4/16/07 - "this attraction between CXCR4 and CXCL12 draws cancer cells to the organs they spread to ... exposure with either DIM or genistein cut movement by 80 per cent"
  • DCA: Cancer Breakthrough or Urban Legend? - ABC News, 2/5/07 - "In one group of rats where DCA was given after the injected tumors had been allowed to grow, the tumors immediately (in the authors' words) decreased in size"
  • A Curry A Day Keeps The Doctor Away? - Science Daily, 1/11/07 - "the chemical compound capsaicin -- which is responsible for the burning sensation when we eat chillies -- can kill cells by directly targeting their energy source ... It could mean that patients could control or prevent the onset of cancer by eating a diet rich in capsaicin" - See curcumin products at Amazon.com.
  • Body Composition May Be Key Player In Controlling Cancer Risks - Science Daily, 1/3/07 - "This study suggests that body composition, being lean as opposed to being obese, has a greater protective effect against cancer"
  • Research shows benefits of cranberries -MSNBC, 11/20/06 - "Cranberries may prevent tumors from growing rapidly or starting in the first place ..." - See cranberry supplements at Amazon.com.
  • Onion and garlic use and human cancer - Am J Clin Nutr. 2006 Nov;84(5):1027-32 - "The multivariate ORs for the highest category of onion and garlic intake were, respectively, 0.16 and 0.61 for cancer of the oral cavity and pharynx, 0.12 and 0.43 for esophageal cancer, 0.44 and 0.74 for colorectal cancer, 0.17 and 0.56 for laryngeal cancer, 0.75 and 0.90 for breast cancer, 0.27 and 0.78 for ovarian cancer, 0.29 and 0.81 for prostate cancer, and 0.62 and 0.69 for renal cell cancer" - See garlic supplements at Amazon.com.
  • Aspirin May Be Newest Cancer Drug - WebMD, 10/2/06 - "In test-tube studies, the researchers find that aspirin does what some of the most cutting-edge new anticancer drugs do. It seems to keep newborn cancers from growing the blood vessels they need to become full-blown tumors -- a process called angiogenesis ... anticancer effect may not be due to blocking Cox enzymes at all"
  • Sun Exposure Cuts Cancer Risk at 16 Sites, Study Says - Medscape, 8/15/06 - "solar ultraviolet B irradiance is associated with reduced risk at 16 sites of cancer through production of vitamin D. These cancers include 6 sites of gastrointestinal cancers, 3 cancers of female sites, 3 urogenital cancers, 2 types of lymphomas, and 2 upper aerodigestive tract cancers"
  • Encouraging Results For Folic Acid As A Cancer Prevention Drug - Science Daily, 6/12/06 - "31 of 43 patients with the precancerous laryngeal lesion called leucoplakia demonstrated 50 percent or greater reduction in the lesion size after six months of taking folate supplements. In 12 of 31 responders, there was no evidence of the original lesion ... Folate deficiency is the most common vitamin deficiency in the United States"
  • Broccoli, Cauliflower And Genetic Cancer - Science Daily, 5/18/06 - "cruciferous vegetables ... are abundant in sulforaphane (SFN) ... those mice fed with an SFN-supplemented diet developed significantly fewer and smaller tumors"
  • Product Review of Supplements for Cancer Prevention (Green Tea, Lycopene, and Selenium) - ConsumerLab.com, 4/20/06
  • Vitamin D May Prevent Cancer Risk - Medscape, 4/10/06 - "For each 25-nmol/L increase in predicted level of 25(OH)D, the risk for cancer decreased by 17%. Higher 25(OH)D levels were associated with a significantly decreased risk for colorectal cancer (RR, 0.63), pancreatic cancer (RR, 0.49), esophageal cancer (RR, 0.37), oral and pharyngeal cancer (RR, 0.30), and leukemia (RR, 0.44). There were no significant relationships between other types of cancer and 25(OH)D levels" - See vitamin D at Amazon.com.
  • Vitamin D May Protect Against Cancer - WebMD, 4/4/06 - "At least half of American adults suffer from vitamin D deficiencies that place them at increased risk of cancer ... taking at least 1,000 international units (IU) of vitamin D daily can slash the risk of breast, colon, and other cancers" - See vitamin D at Amazon.com.
  • Vitamin D and Cancer: A Goldilocks Paradox? - Medscape, 3/30/06 - "In laboratory models, vitamin D reduces cell proliferation and increases cell differentiation, improves cell adhesion, and inhibits cancer progression and metastasis"
  • Vitamin D - Cancer Prevention and Other New Uses - Life Extension Magazine, 3/06 - "Once considered little more than a compound that promotes healthy bones, vitamin D is now recognized as an important weapon in the fight against cancer ... While the Institute of Medicine suggests 400-600 IU of vitamin D daily, the American Medical Women’s Association (AMWA) advises that all men and women over the age of 50 should consume 800-1000 IU of vitamin D each day"
  • Ginkgo Biloba Extract: More Than Just For Memory? - Science Daily, 2/24/06 - "treating mice with an extract of leaves of Ginkgo biloba both before and after implanting human breast or brain (glioma) tumors decreased expression of a cell receptor associated with invasive cancer. This decreased expression slowed the growth of the breast tumors by 80 percent as long as the extract was used, compared to untreated mice" - See ginkgo biloba at Amazon.com.
  • Grapefruit flavonoid could repair DNA, may protect against cancer - Nutra USA, 2/15/06 - "Naringenin, a flavonoid found in grapefruit and oranges, helped to repair damaged DNA in cancer cells"
  • Broccoli chemical's cancer check - BBC News, 2/7/06 - "A chemical in vegetables such as broccoli, cauliflower and cabbage can boost DNA repair in cells and may stop them becoming cancerous ... Vegetables such as broccoli were found to contain a compound called I3C" - See indole-3-carbinol at Amazon.com.
  • How to get vitamin D? - USA Today, 1/29/06 - "Adults who consume 1,000 international units (IU) of vitamin D daily might lower their risks of colon, breast and ovarian cancers by up to 50% ... Essentially no one in the United States is getting that"
  • Vitamin D Needed To Cut Cancer Risk, Researchers Say - Science Daily, 12/28/05 - "Taking 1,000 international units (IU) of vitamin D3 daily appears to lower an individual's risk of developing certain cancers – including colon, breast, and ovarian cancer – by up to 50 percent" - See vitamin D at Amazon.com.
  • The Nude Mouse Tale: Omega-3 Fats Save The Life Of A Terminal Cancer Patient - Science Daily, 11/14/05 - "In 2000 he was told by his doctor he had only a few months to live ... But five years later, he is still alive, and has even gained a little weight ... It was a nutritional intervention, drastically increasing the patient’s intake of omega-3 fatty acids" - See Mega Twin EPA at Amazon.com.
  • A Shopping Cart of Cancer Fighters - Intelihealth, 10/31/05 - "Broccoli sprouts, cabbage, ginkgo biloba and garlic appear to have a role in preventing a variety of cancers"
  • Compounds Found In Cruciferous Vegetables Block Lung Cancer Progression - Science Daily, 9/15/05 - "A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells"
  • Study: Vitamin C May Fight Cancer - WebMD, 9/12/05 - "Vitamin C appeared to boost production of hydrogen peroxide, which killed cancer cells and left healthy cells unharmed ... The levels of vitamin C were so high that they could only be achieved through IV infusions"
  • Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 - "Less than a quarter of the mice in the curcumin-plus-Taxol group had cancer that spread to the lungs. So did half of the curcumin group. In comparison, cancer spread to the lungs in three-fourths of the Taxol group and almost all (95%) mice that got no treatment" - See curcumin at Amazon.com.
  • Scientists: Sunshine May Prevent Cancer - CBS 2 Chicago, 5/21/05 - "vitamin D increasingly seems important for preventing and even treating many types of cancer ... In the last three months alone, four separate studies found it helped protect against lymphoma and cancers of the prostate, lung and, ironically, the skin. The strongest evidence is for colon cancer"
  • Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 - "During a six-year period, women who used statins reduced their risk of breast cancer by more than half (51%) compared with nonusers ... Statin users were 48% less likely to develop lung cancer than nonusers ... statin use reduces the rate of prostate cancer by 54%" - See Zocor at International Anti-aging Systems.
  • Chocolate compound stops cancer cell cycle in lab - Nutra USA, 4/18/05 - "the breast cancer cells stopped dividing when treated with pentamer and that all four proteins were inactivated ... the novel aspect here is that a pattern of several regulatory proteins are jointly deactivated, probably greatly enhancing the inhibitory effect compared to targeting any one of the proteins singly"
  • Grapes May Stop Cancer Cells - WebMD, 3/31/05 - "We are getting direct evidence that these components in grapes work synergistically in fighting cancer"
  • Flavonoids work together to inhibit cancer cells - Nutra USA, 3/30/05 - "Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells"
  • Cancer-Enabling Enzyme Can Be Blocked Naturally: Danish Research Confirms Cancer Breakthrough Approach by Matthias Rath, M.D - Life Extension Foundation, 3/21/05 - "Vitamin C, the amino acids L-lysine and L-proline, and a green tea extract known as Epigallocatechin Gallate (EGCG) work together to synergistically block the spread of cancer cells through connective tissue"
  • Green Tea Extract Shows Potential As An Anti-cancer Agent - Science Daily, 2/23/05 - "green tea extract interrupts a process that is crucial in allowing bladder cancer to become invasive and spread to other areas of the body" - See green tea extract at Amazon.com.
  • Green Tea's Record Against Cancer Grows - WebMD, 2/15/05 - "In effect, the green tea extract may keep the cancer cells confined and localized, where they are easier to treat and the prognosis is better ... you should drink four cups a day. Green tea supplements are also available, and at least one study has shown that you may actually get more powerful antioxidants from supplements than from drinking tea" - See green tea extract at Amazon.com.
  • Dog's tale of survival opens door in cancer research - USA Today, 7/24/02 - "The treatment is a cocktail of so-called anti-angiogenic drugs, which have been widely researched for more than a decade and work by starving tumors of their blood supply. Researchers say the three-drug combination, which Haber mixed into Navy's regular dog food, targets the cancer from many angles ... When researchers heard that Navy was cancer-free after receiving a cocktail of drugs already approved by the Food and Drug Administration — Celebrex, tamoxifen (sold as Nolvadex) and doxycycline — the treatment became known as the Navy Protocol ... Navy's treatment, though experimental, cost $2,000"
  • Carrots may help ward off cancer - BBC News, 2/9/05 - "After 18 weeks, rats who ate carrots along with their ordinary feed, and those given feed and falcarinol supplement were one third less likely to develop full-scale tumours than rats who were given just ordinary feed"
  • Popular Arthritis Drug [Celebrex] KO's Lung Cancer - WebMD, 5/21/02 - "In a small study of 16 patients with early cancer than had not spread beyond the lungs, patients who took Celebrex along with chemotherapy benefited from the treatment, and the cancer virtually disappeared in five patients ... In eight other patients, tumors shrank, and four more patients had stable disease ... The expected complete clinical response rate -- meaning that tumors are no longer visible by X-ray -- with the chemotherapy alone "is just 1%, so these results were very encouraging."" - See my COX-2 inhibitor page for natural COX-2 inhibitors.
  • Vitamin E in Food May Fight Cancer - WebMD, 12/15/04 - "Most supplements provide a different form of the vitamin, alpha-tocopherol ... Gamma-tocopherol aced its lab tests. It inhibited the spread of prostate and lung cancer cells without hurting the healthy cells ... Mixing several forms of vitamin E -- including gamma-tocopherol -- was even better at blocking cancer's spread"  - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Citrus Shows Promise For Certain Childhood Cancer - Science Daily, 12/1/04 - "Orange juice and other citrus contain potent natural compounds – limonoids – which showed dramatic results in killing certain cancer cells"
  • An Apple a Day for Cancer Prevention - WebMD, 10/18/04 - "exposed cancer cells to various antioxidants found in apples ... one type of antioxidant, called procyanidins, triggered a series of cell signals that resulted in cancer cell death ... Rats getting "apple water" for six weeks had half the number of precancerous lesions in their colons compared with rats eating the regular diet ... compared the cancer patients' diets with a group of people without cancer ... Those who ate both green leafy and cruciferous vegetables got "particularly strong" cancer prevention protection"
  • Plant food combo offers higher cancer protection - Nutra USA, 7/19/04 - "rats fed a combination of tomatoes and broccoli had markedly less prostate tumour growth than rats who ate diets containing either food alone"
  • Healthy Lifestyle Can Lower Cancer Risk - WebMD, 7/7/04 - "The nine guidelines to better ensure a cancer-free life are:"
  • Modulation of carcinogen metabolism and DNA interaction by calcium glucarate in mouse skin - Toxicol Sci. 2004 May;79(1):47-55. Epub 2004 Feb 19 - "Cag exerted its antitumor effect possibly by inhibiting the carcinogen-DNA binding, which appears to be due to reduced DNA synthesis and AHH activity"
  • Women: Walk Away From Cancer - WebMD, 3/29/04
  • Green Tea's Cancer-Fighting Target Found - WebMD, 3/15/04 - "the antioxidant, known as EGCG, binds to a protein found on tumor cells and dramatically slows their growth ... the antioxidant required to produce these anticancer effects was equivalent to those found in the body after drinking only two to three cups of green tea"  - See green tea extract at Amazon.com.
  • Intentional Weight Loss of 20 Pounds or More Linked to Decreased Cancer Risk - Doctor's Guide, 12/1/03 - "Compared with women who never had any weight loss episodes of 20 or more pounds, women who had ever experienced intentional weight loss of 20 or more pounds, but not unintentional weight loss, had an 11% reduced risk for any type of cnacer"
  • Cancer Fighter: Vitamin B-6 - Physician's Weekly, 8/11/03 - "Washington State University researchers suggest that consuming more vitamin B-6 can ward off cancer. The vitamin Converts folate to a form the body can use to produce thymine, a component of DNA"
  • Pizza Prevents Cancer? It's Part of the Mediterranean Diet - WebMD, 7/21/03 - "Gallus and colleagues sifted through diet surveys completed by 5,500 Italians ... regular pizza eaters had 34% less risk of oral cavity and pharyngeal cancer, 59% less risk of esophageal cancer, and 25% less risk of colon cancer ... Italian pizza is less than 50% crust, 20% tomato sauce, 20% mozzarella cheese, and 4% olive oil ... There's less refined carbohydrates, plus cooked tomatoes, which are a rich source of lycopene, a natural chemical that has been shown in numerous studies to protect against cancer ... We think that there's a specific compound in cooked tomatoes that is protective"
  • Detoxifying cancer causing agents to prevent cancer - Integr Cancer Ther. 2003 Jun;2(2):139-44 - "There is now growing evidence for the possible control of different stages of the cancer induction by inhibiting beta-glucuronidase with D-glucaric acid derivatives, especially with its salts (D-glucarates) ... the consumption of fruits and vegetables naturally rich in D-glucaric acid or self-medication with D-glucaric acid derivatives such as calcium D-glucarate offers a promising cancer prevention approach"
  • Alpha-Tocopheryl Succinate Seen as Auxiliary Cancer Treatment - AltMedicine.com, 5/22/03 - "alpha-tocopheryl succinate has inhibited and killed both human and rodent cancer cells in test tubes (in vitro) and later in the living body of rodents (in vivo)—without causing normal cells to proliferate. So far, tests in living human bodies have not been conducted"
  • Fruits: Cancer-Fighting Foods - WebMD, 2/19/03 - "Compared with those who ate the least fruit as children, those who ate the most were about 40% less likely to get cancer 60 years later ... a variety of nutritional factors might explain fruit's protective effects, such as their high antioxidant, fiber, and vitamin Content. But when they looked at the cancer-fighting impact of vitamins C, E, and beta carotene separately, no single nutrient emerged as the winner"
  • 70 Percent Of Cancer Is Preventable - thesandiegochannel.com, 2/4/03 - "We have good evidence that breast cancer, prostate cancer, and colon cancer are related to increased dietary fat and too many calories ... As far as something to add to your lifestyle -- physical activity. This can cut your risk of colon and other cancers by as much as a half"
  • In Praise of Spirulina - CancerDecisions.com, 12/12/02 - "In a 2002 Japanese study, 12 adult males were administered an oral hot water extract of spirulina, and the number and activity of their natural killer (NK) cells was measured before and after treatment. (NK cells destroy tumor cells by binding to them and delivering lethal chemicals that kill on contact.) At the study's end, there was a significant increase in the production and cancer-killing ability of these subjects' NK cells ... Spirulina also shows potential for decreasing the adverse effects of both chemotherapy and radiation" - See spirulina at Amazon.com.
  • Nutrients Are Key to Preventing Cancer - Intelihealth, 12/3/02 - "Cancer doesn't just arise overnight. A few tiny cells gone wrong slowly grow over decades. Whether the result is a life-threatening tumor depends on genes and environment including food ... Up to 35 percent of cancers are related to dietary habits ... people who eat lots of fruits and vegetables generally are skinnier. Obesity increases risks of cancers of the uterus, gallbladder and possibly colon and prostate, while a large weight gain after reaching adulthood is linked to breast cancer ... Not everybody gets equal benefit from nutrient-rich diets, a discrepancy that probably points to genetic variability. For example, scientists studying lung cancer rates in part of China found people with the lowest cancer risks also were genetically deficient in an enzyme that metabolizes certain nutrients in cruciferous vegetables"
  • Ability To Cope With Stress May Play A Role In Cancer Progression - Intelihealth, 11/2/02 - "Studies have shown that people who adopt active coping strategies have better immune function and lower cortisol levels, and just the opposite for people who use passive coping strategies"
  • Soy, Cow's Milk May Fight Breast Cancer - WebMD, 9/27/02 - "A combination of soy and cow's milk could have some beneficial, anti-cancer nutrients ... She explains that conjugated linoleic acid, or CLA, is the key to the cow's role in cancer prevention. CLA is a minor fatty acid found in milk and milk products and beef ... He says he thinks the most potent cancer-fighting component of soy is a compound called genistein ... He demonstrated that by feeding rats a diet containing genistein before exposing them to a cancer-causing drug. The number of breast tumors was reduced by 50%" - See conjugated linoleic acid at Amazon.com.
  • Avoiding Weight Gain Has A Major Role In Cancer Prevention - Doctor's Guide, 9/13/02 - "Obesity is linked to colon, breast (in postmenopausal women), endometrium, kidney, and oesophagus ... associations with cancer risk could be explained by alterations in the metabolism of endogenous hormones, including sex steroids, insulin, and insulin-like growth factors. These can lead to distortion of the normal balance between cell proliferation, differentiation, and apoptosis"
  • Experts outline convincing evidence on diet and cancer - USA Today, 9/13/02 - "Poor diet is thought to account for about 30% of cancer"
  • Aspirin Lowers Pancreatic Cancer Risk - WebMD, 8/6/02 - "A new study shows regular use of aspirin might lower your risk of one of the deadliest forms of cancer ... women who used aspirin cut their risk of developing pancreatic cancer nearly in half ... the more aspirin use a woman reported, the less likely she was to develop pancreatic cancer ... Other NSAIDs did not have the same effect"
  • Sunlight, A Cancer Protector In The Guise Of A Villain? - Intelihealth, 8/6/02 - "Their theory was that vitamin D, which the skin produces when exposed to sunshine, somehow prevents the growth of malignant cells ... researchers are looking into vitamin D as a possible remedy. Clinical trials in people are now under way, testing whether the vitamin or similar compounds can treat tumors or bolster chemotherapy"
  • Novel Method of Enhancing Anti-Fat Effects of CLA - Life Extension Magazine, 8/02 - "CLA is not just for fat-loss. Studies show it may help protect against many diseases including atherosclerosis and cancer ... CLA is also able to inhibit the growth of prostate cancer. CLA, as the article went on to say, can be considered a powerful prostate cancer preventative, as well as a partial treatment" - See conjugated linoleic acid at Amazon.com.
  • Green Tea Cancer Benefits Detailed - USA Today, 7/9/02 - "polyphenols in green tea help eliminate free radicals ... Hsu discovered the polyphenols actually separate healthy cells containing the P-57 protein from cancer cells, which lack the protein. While the healthy cells are sent to safety, the polyphenols attack the cancer cells ... The polyphenols go after the cancer cells' mitochondria, the main energy source in cells. The destruction of the mitochondria weakens the cancer cells, and eventually leads to their death" - See green tea extract at Amazon.com.
  • A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine, 7/02 - "Imagine a natural substance so smart it can tell the difference between a cancer cell and a normal cell; so powerful it can stop chemicals in their tracks; and so strong it can enable DNA to walk away from lethal doses of radiation virtually unscathed. Curcumin has powers against cancer so beneficial that drug companies are rushing to make drug versions. Curcumin is all this and more" - See curcumin at Amazon.com.
  • Vitamin K Therapy Slows Spread of Liver Cancer - Doctor's Guide, 5/29/02 - "Results show that 59 percent of patients treated with vitamin K-II were alive at two years compared to 29 percent of those who were not given vitamin K-II (p=0.14). Invasion of the cancer into the portal vein occurred in 2 percent of the vitamin K-II treated group at one year and in 13 percent at two years, compared to 21 and 55 percent of controls, respectively" - Vitamin K3 (menadione sodium bisulfite) is put in animal foods and animal vitamins. Places that sell it in bulk are http://www.dyets.com/ordering.htm ($156/kilogram).  A company at 360-387-0129 called me and said they sell it also.  Also see liver cancer.
  • Black Raspberries Fight Cancer - WebMD, 5/3/02 - "Earlier studies have shown that blueberries and strawberries also have cancer-preventing properties. But black raspberries seem to work even better. Berries are chock full of antioxidants, chemicals that help block tumors from forming. Antioxidants sop up cancer-causing molecules called free radicals -- damaging substances produced from your body's everyday functions"
  • Common Foods Help Prevent Cancer - WebMD, 4/10/02 - "found that regular green tea drinking cut cancer risk in half ... men who ate more than two servings of tomato sauce per week had a 23% lower risk of prostate cancer than men who ate less than one serving a week"
  • Exposure To Sunlight Lowers Risks Of Four Cancers - Doctor's Guide, 4/4/02 - "exposure to sunlight contributes to non-melanoma skin cancer. "By contrast, several ecological studies suggest that sunlight may protect against female breast, ovarian, prostate, and colon cancer, all diseases that contribute to a substantially higher proportion of cancer mortality in the western industrialized world." ... Some studies have suggested an association between circulating vitamin D in blood, which is largely derived from sunlight, or dietary vitamin D and colorectal, prostate and female breast cancers"
  • The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 - Br J Cancer 2002 Mar 4;86(5):774-8 - "This observation provides a novel explanation for the cancer preventative properties of resveratrol. It demonstrates that a natural dietary cancer preventative agent can be converted to a compound with known anticancer activity by an enzyme that is found in human tumours"
  • Sun May Protect Against Some Cancers - WebMD, 3/14/02 - "new findings from an independent researcher suggest that getting too little sun may increase the risk of dying from a host of other cancers ... Sunlight exposure increases the body's production of vitamin D. People who get lower amounts of sunlight exposure therefore manufacture lower amounts of vitamin D. Grant says vitamin D may have a protective effect and taking vitamin D supplements might offer adequate protection to people who get little natural sunlight"
  • New research shows how broccoli beats cancer - Life Extension Magazine, 11/01 - "Sulforaphane is most highly concentrated in broccoli, as well as in other cruciferous vegetables, such as Brussels sprouts, cabbage and cauliflower ... animal studies to date have shown that sulforaphane can dramatically reduce the number of malignant tumors, reproduction, growth rate and size, as well as delay cancer onset"
  • Unlocking the power of curcumin - Life Extension Magazine, 9/01 - "research is discovering that curcumin is a powerful carcinogenic inhibitor, slowing cancerous cell proliferation by inducing apoptosis, a pre-programmed set of processes within a cell that results in its death"
  • Report: An Innovative Approach to Cancer Therapy - Life Extension Foundation, 8/01 - "For cancer patients the main anti-cancer supplements are pancreatic enzymes"
  • Study: Power Lines May Aid Cancer Cells - Intelihealth, 10/29/01 - "electromagnetic fields disrupted the functioning of the hormone melatonin in individual cells ... Scientists have accepted since 1987 that the substance suppresses the multiplication of cancer cells ... They exposed two batches of the [breast cancer] cell to two different levels of electromagnetic field ... In both cases, the ability of melatonin to suppress the growth of the cancer cells was found to have declined. In some cells with smaller concentrations of melatonin, the suppressive effect was entirely absent"
  • Red Wine, Coffee, and Almonds May Lower Prostate Cancer Risk, Protective Effect Linked to Dietary Boron - WebMD, 4/5/01 - "men who consumed the greatest amount of boron were 64% less likely to develop prostate cancer, when compared with men who consumed the least amount of boron"
  • Vitamin B12: Surprising New Findings - Life Extension Magazine, 12/00 - "High levels of homocysteine are consistently linked with DNA damage ... the accepted standard for vitamin B12 sufficiency (i.e., plasma concentration <150 pmol/L) may not be adequate to minimize chromosome damage rates"
  • Ulcer Therapy, Vitamins May Team Up to Prevent Stomach Cancer, Drugs Halted, Healed Abnormalities With Cancer Potential - WebMD, 12/8/00 - "people who took the three-drug combination alone or in combination with vitamin C and/or beta carotene were three to five times more likely than people who received no treatment to have a reduction in the size of precancerous stomach abnormalities."
  • Flaxseed Lignans Show - Nutrition Science News, 10/00 - "The plant lignans found in flax, namely matairesinol and secoisolariciresinol, must be converted by gut bacteria to mammalian lignans, namely enterolactone and enterodiol. These mammalian lignans have been shown to have chemoprotective effects in cell and animal studies ... Epidemiological studies show breast cancer patients have low urinary excretion of enterolcatone and enterodiol, suggesting that consumption of lignans may exert cancer-preventive or protective effects"
  • Astragalus Asserts Immunity - Nutrition Science News, 10/00 - "breast cancer patients given a combination of astragalus and ligustrum as an adjunct to irradiation treatments showed a statistically significant decrease in deaths from one in two to one in 10 ... In another study of patients with advanced non-small-cell lung cancer, the effectiveness of conventional chemotherapy (chemotherapeutic regimen not reported) was compared to the effectiveness of chemotherapy in conjunction with the same astragalus-ligustrum preparation. Those with squamous carcinoma of the lung showed a significant increase in mean survival time from 204 to 465 days"
  • Studies Suggest Eating Garlic Does Protect Against Cancers - WebMD, 10/4/00 - "studies suggest that there may be a 30 to 50% reduction in colorectal cancer in people who eat a lot of garlic"
  • Diet Tips To Stave Off Cancer - Intelihealth, 9/5/00 - "Make sure two-thirds of your plate is filled with fruits, vegetables, grains and beans and only one-third is devoted to meat, poultry or fish"
  • Chemicals in apples slow cancer growth in lab tests, scientists report - CNN, 8/30/00 - "The stronger the concentration of apple extract, the slower the rate of reproduction among the cancer cells ... The anti-cancer effect, a spokesman said, was strongest in extracts made from unpeeled apples"
  • One More Reason To Eat Your Broccoli, Chemical Compounds Found to Prevent Lung Cancer - WebMD, 8/25/00 - "The protection comes from chemicals known as isothiocyanates that are found in these vegetables ... men with no detectable levels of isothiocyanates had a 36% greater chance of developing lung cancer than those who did have the chemical in their bodies ... isothiocyanates inactivate certain cancer-causing chemicals in tobacco smoke. The compounds may also work as antioxidants to help prevent natural damage to cells in the body"
  • CLA and Cancer - Life Extension Magazine, 4/00 - "feeding CLA to female rats while they were young and still developing conferred life-long protection against breast cancer"
  • Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals - Am J Clin Nutr. 1997 Dec;66(6 Suppl):1523S-1529S - "Conjugated linoleic acid is unique in the sense that concentrations < or = 1% are sufficient for producing significant cancer protection and that this effect seems to be independent of the other fatty acids." - see my CLA page
  • Natural Sugar-Phosphate Compound Shows Promise In Cancer - Doctor's Guide, 3/30/98  - "What if a common, naturally occurring substance could shrink tumors, stop their growth, even make cancer cells normal again? A University of Maryland School of Medicine researcher is finding that it can." - see my IP-6 page
  • Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 - "The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases"

Other News:

  • Glucose control is a key factor for reduced cancer risk in obesity and type 2 diabetes - Science Daily, 12/6/21 - "the results show a 60% reduction in cancer risk in the group where normal glucose control was maintained over 10 years"
  • Is there an association between a history of military service and cancer diagnosis? Results from a US national-level study of self-reported outcomes - Cancer Causes Control 2020 Oct 16 - "Compared to men with no military service history, men with a military service history were older (median of 65 [IQR 56, 74] vs. 53 [IQR 41, 62] years, p < 0.0001), more commonly Caucasian (71.4% vs. 61.4%, p < 0.0001), born in the US (95.6% vs. 79.5%, p < 0.0001), attained higher education level and annual household income (p < 0.0001), and consisted of more smokers(58.3% vs. 44.5%, p < 0.0001). The age-adjusted comparison demonstrated a higher cancer prevalence in men with military service history (20.5% vs. 7.6%, p < 0.0001). Specifically, genitourinary, dermatological, gastrointestinal, and hematological cancers were generally more prevalent. Adjusting for all available confounders, multivariable models showed that military service history was associated with 1.56 (95% CI 1.20-2.03), and 1.57 (95% CI 1.07-2.31) increased odds of having any cancer, and specifically genitourinary cancer, respectively"
  • Dozens of non-oncology drugs can kill cancer cells - Science Daily, 1/20/20 - "They found nearly 50 non-cancer drugs -- including those initially developed to lower cholesterol or reduce inflammation -- that killed some cancer cells while leaving others alone ... Some of the compounds killed cancer cells in unexpected ways. "Most existing cancer drugs work by blocking proteins, but we're finding that compounds can act through other mechanisms," said Corsello. Some of the four-dozen drugs he and his colleagues identified appear to act not by inhibiting a protein but by activating a protein or stabilizing a protein-protein interaction. For example, the team found that nearly a dozen non-oncology drugs killed cancer cells that express a protein called PDE3A by stabilizing the interaction between PDE3A and another protein called SLFN12 -- a previously unknown mechanism for some of these drugs ... For example, the anti-inflammatory drug tepoxalin, originally developed for use in people but approved for treating osteoarthritis in dogs, killed cancer cells by hitting an unknown target in cells that overexpress the protein MDR1, which commonly drives resistance to chemotherapy drugs ... For example, the alcohol dependence drug disulfiram (Antabuse) killed cell lines carrying mutations that cause depletion of metallothionein proteins. Compounds containing vanadium, originally developed to treat diabetes, killed cancer cells that expressed the sulfate transporter SLC26A2" - Reminds me of this from 18 years ago but we never heard anything further about it:
    • Dog's tale of survival opens door in cancer research - USA Today, 7/24/02 - "The treatment is a cocktail of so-called anti-angiogenic drugs, which have been widely researched for more than a decade and work by starving tumors of their blood supply. Researchers say the three-drug combination, which Haber mixed into Navy's regular dog food, targets the cancer from many angles ... When researchers heard that Navy was cancer-free after receiving a cocktail of drugs already approved by the Food and Drug Administration — Celebrex, tamoxifen (sold as Nolvadex) and doxycycline — the treatment became known as the Navy Protocol ... Navy's treatment, though experimental, cost $2,000"
  • New chemical weapon to combat cancer - Science Daily, 10/23/19 - "C2 -- which consists of four products (tubacin, CI-994, erlotinib and dasatinib) -- is developing a new and highly promising mechanism of action ... During our in vitro tests, we found that C2 killed up to 20 times more cancer cells than other combinations, while sparing healthy cells"
  • How diabetes can increase cancer risk: DNA damaged by high blood sugar - Science Daily, 8/25/19 - "Exposure to high glucose levels leads to both DNA adducts and the suppression of their repair, which in combination could cause genome instability and cancer" - Note:  I suspected that a long time ago which is why I take diabetes medications (metformin and generic Actos) even though I'm not diabetic.  It's been said for a long time that sugar fuels cancer.
  • Cancer Survivors May Have Lower Odds for Dementia - WebMD, 6/21/19 - "There are theories as to why the pattern exists: Some of the mechanisms that allow cancer cells to grow and spread may, in the brain, protect cells from dying ... Glymour's team points to the example of an enzyme called PIN1: Its activity is enhanced in cancer, but decreased in Alzheimer's. Among other roles, the enzyme is thought to help prevent the buildup of abnormal proteins in the brain that are the hallmark of Alzheimer's"
  • Flight Attendants May Have Higher Cancer Rates - Medscape, 6/26/18 - "flight attendants were 51 percent more likely to develop breast cancer. They also had more than double the risk of melanoma and more than quadruple the odds of being diagnosed with other forms of skin cancer ... Scientists have long suspected that flight attendants' cancer risk might be affected by their exposure to naturally occurring radiation at high altitudes, shift work, time zone changes that disrupt sleep cycles, and poor cabin air quality"
  • Female night shift workers may have increased risk of common cancers - Science Daily, 1/8/18 - "Overall, long-term night shift work among women increased the risk of cancer by 19 percent. When analyzing specific cancers, the researchers found that this population had an increased risk of skin (41 percent), breast (32 percent), and gastrointestinal cancer (18 percent) compared with women who did not perform long-term night shift work"
  • Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta-analysis - Int J Cancer. 2016 May 13 - "In a meta-analysis of 10 studies, statin use was associated with improved recurrence-free survival (RFS) (HR 0.64; 95% CI 0.53- 0.79, I2 = 44%). Furthermore, this RFS benefit appeared to be confined to use of lipophilic statins (HR 0.72; 95% CI 0.59- 0.89) as hydrophilic statin use was not associated with improvement in RFS (HR 0.80; 95% CI 0.44- 1.46). Statin users similarly showed improved overall survival in a meta-analysis with substantial heterogeneity (8 studies, HR 0.66; 95% CI 0.44-0.99, I2 = 89%). Statin users also had improved cancer-specific survival, although this relationship was measured with less precision (6 studies, HR 0.70"
    • Which Statin Is Right for My Patient? - Medscape, 8/28/07 - "Atorvastatin, lovastatin, and simvastatin are lipophilic, whereas pravastatin, rosuvastatin, and fluvastatin are more hydrophilic"
  • Study: Up to 90 percent of cancers not ‘bad luck,’ but due to lifestyle choices, environment - Washington Post, 12/17/15 - "Led by a team at Stony Brook, the research used four approaches, including stem cell experiments, computer modeling and molecular "fingerprinting" of cancers, to conclude that 70 to 90 percent of your lifetime cancer risk could be due to external factors"
  • High hemoglobin A1c levels within the non-diabetic range are associated with the risk of all cancers - Int J Cancer. 2015 Nov 6 - "Compared to individuals without known diabetes and HbA1c levels of 5.0-5.4%, the HRs for all cancers were 1.27 (95% confidence interval, 1.07-1.52); 1.01 (0.90-1.14); 1.28 (1.09-1.49); and 1.43 (1.14-1.80) for individuals without known diabetes and HbA1c levels <5.0%, 5.5-5.9%, 6.0-6.4%, and ≥6.5%, respectively, and 1.22 (1.02-1.47) for individuals with known diabetes. The lowest HbA1c group had the highest risk of liver cancer, and HbA1c levels were linearly associated with the risk of all cancers after excluding liver cancer ... our findings corroborate the notion that glycemic control in individuals with high HbA1c levels may be important not only to prevent diabetes but also to prevent cancer"
  • Statins and Lower Cancer Mortality; Risk Cut by Up to a Half - Medscape, 6/10/15 - "statin use was associated with a 22% reduction in deaths from various cancer types in women and a 55% reduction in deaths from bone/connective tissue cancers. The study in men looked at statin use together with the antidiabetes medication metformin and found a 40% reduction in prostate cancer mortality, with the effect more pronounced in men with obesity/metabolic syndrome ... the researchers speculate that statins interfere with cell growth and metastasis by blocking cholesterol production, thereby affecting molecular pathways and the inflammatory response"
  • Cancer Rates Higher in Type 1 and Type 2 Diabetes - WebMD, 12/16/14 - "It's not likely that insulin is the driving force behind the cancers ... Instead, they suggest that high blood sugar, which doctors call hyperglycemia, may be a contributing factor" - Note:  I wouldn't take that as written in stone.  It's like what came first, the chicken or the egg (high blood sugar or high insulin in the form of insulin resistance)?
  • Dose effect of thiazolidinedione on cancer risk in type 2 diabetes mellitus patients: a six-year population-based cohort study - J Clin Pharm Ther. 2014 Mar 24 - "The adjusted HRs for those prescribed TZD were 0.74 (95% CI 0.43-1.26, P = 0.27), 0.39 (95% CI 0.33-0.45, P < 0.001) and 0.49 (95% CI 0.27-0.89, P = 0.02), respectively, relative to non-DM patients, DM patients prescribed other anti-DM drugs besides TZDs and DM patients not prescribed any anti-DM drugs. In addition, the effects of TZDs were shown to be significantly dose dependent (P for trend < 0.001). The risk of breast, brain, colorectal, ear-nose-throat, kidney, liver, lung, lymphatic, prostate, stomach, and uterus cancer was significantly lower in those prescribed TZDs"
  • Diets Heavy in Meat Boost Risk for Certain Cancers - Medscape, 1/10/14 - "smoking and diets rich in animal products have the strongest correlations with cancer incidence rates ... The strongest correlation with animal products was seen in cancers of the female breast, corpus uteri, kidney, ovaries, pancreas, prostate, testicles, and thyroid, and in multiple myeloma ... alcohol consumption was found to be significantly correlated with only colorectal cancer ... Added sweeteners were also associated with an increased incidence of brain cancer in women, and in corpus uteri, pancreatic, and prostate cancers. Cereals were associated with a decreased incidence of kidney and prostate cancer ... there is a 15- to 30-year lag between diet and cancer incidence ... animal fat is an important risk factor for lung cancer ... higher latitudes (where there is less UVB, and consequently less vitamin D absorption) were associated with higher rates of cancer"
  • Lowered Cancer Risk With ACE Inhibitors/ARBs: A Population-Based Cohort Study - J Clin Hypertens (Greenwich). 2013 Nov 8 - "Using the Taiwan National Health Insurance Research Database, 297,688 eligible study patients with essential hypertension were identified. According to their antihypertensive prescriptions, the study patients were stratified into an ACE inhibitor group, an ARB group, or a control group ... In the ACE inhibitor group compared with the control group, the hazard ratio was 0.51 (95% confidence interval, 0.39-0.68). In the ARB group compared with the control group, the hazard ratio was 0.8 (95% confidence interval, 0.65-0.97). Regular use of ACE inhibitors/ARBs was not associated with an increased risk of cancer development and was actually found to decrease overall cancer risk in this study"
  • Some Diabetes Drugs May Affect Cancer Risk in Women - WebMD, 12/6/13 - "Cleveland Clinic researchers analyzed data from more than 25,600 women and men with type 2 diabetes ... The drugs included "insulin sensitizers," which lower blood sugar and insulin levels in the body by increasing the muscle, fat and liver's response to insulin. The other drugs analyzed were "insulin secretagogues," which lower blood sugar by stimulating beta cells in the pancreas to make more insulin ... The use of insulin sensitizers in women was associated with a 21 percent decreased cancer risk compared to insulin secretagogues, the investigators found. Furthermore, the use of a specific insulin sensitizer called thiazolidinedione was associated with a 32 percent decreased cancer risk in women compared to sulphonylurea, an insulin secretagogue ... there were no significant differences between men who used insulin sensitizers or secretagogues"
  • Diabetes increases risk of developing and dying from breast and colon cancer - Science Daily, 9/27/13 - "analyzed results from 20 trials that had taken place between 2007 and 2012, involving more than 1.9 million patients with breast or colon cancer, with or without diabetes ... patients with diabetes had a 23% increased risk of developing breast cancer and a 38% increased risk of dying from the disease compared to non-diabetic patients. Diabetic patients had a 26% increased risk of developing colon cancer and a 30% increased risk of dying from it compared to non-diabetic patients"
  • Statin use and reduced cancer-related mortality - N Engl J Med. 2012 Nov 8 - "Multivariable-adjusted hazard ratios for statin users, as compared with patients who had never used statins, were 0.85 (95% confidence interval [CI], 0.83 to 0.87) for death from any cause and 0.85 (95% CI, 0.82 to 0.87) for death from cancer"
  • Cancer mortality according to lipid-lowering drugs and lipoproteins in a general population - Curr Med Res Opin. 2011 Sep 7 - "The beneficial effect of lipid-lowering drugs (LLD) on cardiovascular risk is established, but long term safety data remain scarce. Our aim was to assess 10-year risk of cancer mortality according to blood lipoprotein levels and LLD exposure, in a general population ... There were 3262 participants and 177 deaths were recorded over the 10-year period (78 due to a cancer). The sample comprised 64% of normolipidaemic, 25% of untreated dyslipidaemic and 11% of dyslipidaemic subjects treated with LLD (4% statins, 6% fibrates and 1% other hypolipidaemic drugs). After adjustment for centre, age, gender, smoking, gamma-glutamyl transpeptidase and mean corpuscular volume, the hazard ratios (HR) for cancer mortality in subjects with non-HDL cholesterol <3.5 mmol/L (135 mg/dL) and in those with HDL cholesterol <0.90 mmol/L (35 mg/dL) were 2.74 (95% confidence interval: 1.66-4.52, p < 0.001) and 2.83 (1.62-4.96, p < 0.001), respectively. The adjusted HR for cancer mortality was 0.31 (0.11-0.86, p = 0.025) in people on LLD compared to untreated subjects. Conclusions: In the present study, we confirm the significant association between low cholesterol and cancer mortality without finding any harmful signal regarding cancer risk associated with the use of LLD"
  • Simple sugar, lactate, is like 'candy for cancer cells': Cancer cells accelerate aging and inflammation in the body to drive tumor growth - Science Daily, 5/26/11 - "lactate is like "candy" for cancer cells. And cancer cells are addicted to this supply of "candy." ... We've essentially shown for the first time that there is lactate shuttle in human tumors ... If lethal cancer is a disease of "accelerated aging" in the tumor's connective tissue, then cancer patients may benefit from therapy with strong antioxidants and anti-inflammatory drugs ... Antioxidant therapy will "cut off the fuel supply" for cancer cells." Antioxidants also have a natural anti-inflammatory action"
  • How inflammation can lead to cancer - Science Daily, 4/19/11 - "inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155) ... This, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can lead to cancer ... It is believed that cancer is caused by an accumulation of mutations in cells of the body ... Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally"
  • Biophysicist targeting IL-6 to halt breast, prostate cancer - Science Daily, 4/19/11 - "There is an inherent connection between inflammation and cancer ... In the case of breast cancers, a medical review systematically tabulated IL-6 levels in various categories of cancer patients, all showing that IL-6 levels elevated up to 40-fold, especially in later stages, metastatic cases and recurrent cases ... The current research offers us an exciting new therapeutic paradigm: targeting tumor microenvironment and inhibiting tumor stem cell renewal, leading to a really effective way to overcome breast tumor drug resistance, inhibiting tumor metastasis and stopping tumor recurrence" - Note:  See the "Alternative News" section of my IL-6 page and my inflammation page for ways to reduce IL-6.
  • Avoiding or controlling diabetes may reduce cancer risk and mortality - Science Daily, 4/3/11 - "Previous epidemiologic studies have shown an association between diabetes and an increased risk for cancers including colorectal, liver and pancreas ... As for mortality, diabetes was associated with an 11 percent increased risk in women and a 17 percent increased risk in men ... diabetes was associated with a significant increase in risk for colon, rectal and liver cancers among men and women. In men, diabetes was associated with an increased risk for pancreatic and bladder cancers; in women, it was associated with an increased risk for stomach, anal and endometrial cancers. No association was found between diabetes and lung, skin or other cancers"
  • Physical symptoms prevalent no matter what stage of cancer including remission - Science Daily, 10/11/10
  • Stress accelerates breast cancer progression in mice, researchers find - Science Daily, 9/15/10 - "stress is biologically reprogramming the immune cells that are trying to fight the cancer, transforming them instead from soldiers protecting the body against disease into aiders and abettors. The study found a 30-fold increase in cancer spread throughout the bodies of stressed mice compared to those that were not stressed ... Beta blockers, used in this study to shut down the stress pathways in the mice, are currently being examined in several large breast cancer databases for their role in potential prevention of recurrence and cancer spread ... using beta blockers in stressed mice prevented the same cancer progression seen in the stressed mice that did not receive medication"
  • Experts explore emerging evidence linking diabetes and cancer - Science Daily, 6/16/10 - "Possible mechanisms for a direct link between diabetes and cancer include hyperinsulinemia, hyperglycemia, and inflammation"
  • The impact of alcohol consumption on the risk of cancer among men: A 20-year follow-up study from Finland - Eur J Cancer. 2010 May 3 - "About 6.7% of the cancer cases in this cohort were due to alcohol consumption"
  • Excessive alcohol consumption may lead to increased cancer risk - Science Daily, 4/21/10 - "Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening ... Telomeres are found at the region of DNA sequences at the end of a chromosome, and are important for the genetic stability of cells. As people age, telomere length shortens progressively ... Since telomere shortening is thought to increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer ... telomere length was dramatically shortened in those who consumed heavy amounts of alcohol; telomere length was nearly half as long as telomere length in the non-abusers (0.41 vs. 0.79 relative units)"
  • Insulin used to treat diabetes may be linked to increased cancer risk, review suggests - Science Daily, 3/2/10 - "Research suggests that metformin, which is used to treat some patients with diabetes, may provide a protective effect, while insulin and/or certain insulin analogues may promote tumour growth ... Diabetic patients were 30 per cent more likely to develop colorectal cancer ... Women with diabetes had a 20 per cent greater risk of developing breast cancer ... People with diabetes had an 82 per cent higher risk of developing pancreatic cancer" -  Note:  See my Insulin and Aging page.  I think it's like what came first the chicken or the egg.  I don't believe they know whether it's the insulin or the high blood sugar.  This seems to support that it's the high insulin.
  • Increased Cancer Risk Seen With Higher Blood Glucose Levels - Medscape, 1/28/10 - "in men, each 1 mmol/L (18 mg/dL) increment in blood glucose level was associated with a 5% increase in incident cancer risk and a 15% increase in fatal cancer risk ... In women, each 1 mmol/L increase in blood glucose level was associated with an 11% increase in incident cancer risk and a 21% increase in fatal cancer risk ... For men, there were glucose-related increases in the risks of incident and fatal cancer of the liver, gallbladder, and respiratory tract; incident thyroid cancer and multiple myeloma; and fatal rectal and colon cancer .... For women, there were glucose-related increases in the risks of incident and fatal pancreatic and stomach cancer; incident urinary bladder cancer and endometrial cancer; and fatal cervical and uterine corpus cancer. In women, there was also an inverse association of blood glucose with incident thyroid cancer risk ... For men and women combined, higher glucose increased the risk of death from oropharyngeal and esophageal cancers"
  • Metformin associated with lower cancer mortality in type 2 diabetes (ZODIAC-16) - Diabetes Care. 2009 Nov 16 - "Median follow-up time was 9.6 years, average age at baseline was 68 years, and average HbA1c was 7.5%. Five hundred seventy patients died, of which 122 from malignancies. SMR for cancer mortality was 1.47 (95%CI 1.22-1.76). In patients taking metformin compared to patients not taking metformin at baseline, the adjusted hazard ratio (HR) for cancer mortality was 0.43 (95%CI 0.23-0.80), and the HR with every increase of 1 gram of metformin was 0.58 (95%CI 0.36-0.93) ... In general, patients with type 2 diabetes are at increased risk for cancer mortality. In our group, metformin use was associated with lower cancer mortality when compared to non-metformin use. Although the design cannot be conclusive about causality, our results suggest a protective effect of metformin on cancer mortality"
  • Low Cholesterol May Be Marker of Undiagnosed Cancer - Medscape, 11/5/09 - "This finding supports the idea that the low serum cholesterol levels that we detected as a possible risk factor may actually have been the result of undiagnosed cancers," he added. "In addition, we observed a greater decline in total serum cholesterol from baseline to 3 years, specifically among the cases that were diagnosed in the early half of the observation, as opposed to the latter portion ... higher HDL cholesterol levels were associated with a decreased risk for cancer (>55.3 vs <36.2 mg/dL; RR for the highest vs the lowest quintile, 0.89; 95% CI, 0.83 - 0.97; P = .01). This inverse association of HDL cholesterol was evident for cancers of the lung, prostate, liver, and hematopoietic system"
  • Cholesterol-lowering Medicines May Be Effective Against Cancer - Science Daily, 11/2/09 - "Our results support the idea that statins can be used in more ways than just to lower cholesterol," says Pilon. "Not least that they can prevent the growth of cancer cells caused by lipid-modified proteins, but also that they can be effective in the treatment of diabetes and neurological disorders such as Parkinson's."
  • Diabetes Drug Shows Promise In Fighting Lethal Cancer Complication - Science Daily, 9/24/09 - "in an animal study, a diabetes drug that promotes insulin sensitivity slowed the progression of muscle wasting and fat loss, the main consequences of a syndrome called cachexia ... Research suggests that cachexia is responsible for between one-fifth and one-third of all cancer deaths ... These data provide evidence that in mice with colon cancer tumors, insulin resistance may be involved in the development of cachexia rather than occur as a result of cachexia ... Within eight days, the mice with cancer receiving the rosiglitazone showed more sensitivity to insulin than did the mice with tumors that received no medication. The insulin sensitivity of the medicated mice matched that of mice without tumors ... In addition to stopping fat and muscle loss, the rosiglitazone also dramatically reduced two biological markers present when proteins break down, particularly in muscles, and a third marker that indicates cells are eating their own amino acids in an attempt to survive" - Note:  I don't know why they did this study with rosiglitazone.  That's the one that may be connected to heart disease.  Pioglitazone is the same class of drug and is not connected to heart disease.  I take it for anti-aging also.  See my Insulin and Aging page.
  • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes - Diabetes Care. 2009 Jun 29 - "Activation of AMPK can suppress tumour formation and inhibit cell growth, in addition to lowering blood glucose levels. We tested the hypothesis that metformin reduces the risk of cancer in people with type 2 diabetes ... Cancer was diagnosed among 7.3% of 4,085 metformin users compared with 11.6% of 4,085 comparators, with median times to cancer of 3.5 years and 2.6 years respectively (p < 0.001). The unadjusted hazard ratio for cancer was 0.46 (0.40-0.53). After adjusting for sex, age, BMI, HbA1c, deprivation, smoking and other drug use, there was still a significantly reduced risk of cancer associated with metformin: 0.63 (0.53-0.75)" - See metformin at The Antiaging Store.
  • Common Diabetes Drug May 'Revolutionize' Cancer Therapies: Unexpected T-cell Breakthrough - Science Daily, 6/4/09 - "We used metformin, which is known to operate on fatty-acid metabolism, to enhance this process, and have shown experimentally in mice that metformin increases T-cell memory as well as the ensuing protective immunity of an experimental anti-cancer vaccine"
  • 'Cancer hope' from diabetes drug - BBC News, 6/3/09 - "Tests on mice found metformin, used for Type 2 diabetes, helps the body's T-cells work more effectively"
  • New Anti-cancer Drug: 200 Times More Active In Killing Tumor Cells - Science Daily, 3/25/09 - "In humans, compounds like BPH-715 and zoledronate have an added benefit in fighting cancer: They spur the proliferation of immune cells called gamma delta T-cells, which aid in killing tumor cells ... The new drugs are about 200 times more effective than the drugs used in recent clinical trials at killing tumor cells and in activating gamma delta T-cells to kill tumor cells ... They also prevent tumor progression in mice much better than do existing bisphosphonate molecules" - Note:  I sounds like hope with terminal cancer, something I was looking for when they inaccurately told me I had terminal neck cancer.
  • 'Miracle Dog' Beats Aggressive Cancer - WebMD, 3/23/09 - "the drug is made of a cancer-killing substance called nitric oxide, which is attached to vitamin B12. Substances called receptors on a cell's surface attract the vitamin and help it enter the cell. Cancer cells grow abnormally fast with extra B12 receptors. NO-Cbl spots these receptors, sneaks into cancer cells, and releases the nitric oxide, which kills the cancer cells from within"
  • Million Women Study Shows Even Moderate Alcohol Consumption Associated With Increased Cancer Risk - Science Daily, 2/24/09 - "Low to moderate alcohol consumption among women is associated with a statistically significant increase in cancer risk and may account for nearly 13 percent of the cancers of the breast, liver, rectum, and upper aero-digestive tract combined"
  • ACE Inhibitors May Protect Diabetics From Cancer, Peptic Ulcer - Medscape, 12/19/08 - "There was a significant association between ACE inhibitor use and the risk for cancer, with an adjusted odds ratio of 0.59 ... The rate of cancer among users of ACE inhibitors was 10% vs 15% for nonusers ... There was also a significant association between ACE inhibitor use and peptic ulcer disease, with an odds ratio of 0.68 ... The rate of peptic ulcer disease among ACE inhibitor users was 12% vs 16% among nonusers"
  • Key Mechanism Behind Cancer Spread Is Explained - Science Daily, 10/30/08
  • Palms Can Foretell Cancer - WebMD, 9/23/08 - "The symptoms: curling or thickening of the palm with swelling of the fingers, making the hand look wooden. It's called PFPAS -- palmar fasciitis and polyarthritis syndrome"
  • Untapped Potential Of Antidepressants For Cancer - Science Daily, 9/11/08 - "Antidepressants work by affecting levels of chemicals known as prostaglandins. These are ephemeral, infinitesimal signallers self-regulating every cell in the body, including those serving mood and immunity ... Prostaglandins are responsible, paradoxically, for both cell function and dysfunction. Excessive prostaglandin synthesis depresses immune function and may induce cancer ... An ideal anticancer agent would inhibit prostaglandins in such a manner as to shut down the pathogenesis of cancer. The article indicates that antidepressants have such properties"
  • Modafinil Reduces Severe Cancer Fatigue - Clinical Psychiatry News, 8/08 - "Among those with severe fatigue at baseline, patients on modafinil had significantly greater reductions in fatigue, compared with those on placebo" - See modafinil at International Anti-aging Systems.
  • Treatment Can Make Cancer Stronger - WebMD, 6/10/08 - "About half of patients are cured -- that is, all of their tumor cells die ... The other half of the time, some tumor cells survive treatment. These cancer cells are more aggressive than they were before treatment"
  • Narcolepsy Drug Fights Cancer Fatigue - WebMD, 6/4/08 - "The narcolepsy drug Provigil may help to relieve the debilitating fatigue often experienced by cancer patients undergoing chemotherapy ... patients taking the drug who had the most severe fatigue at the beginning of the study demonstrated significant improvement, compared with those in the placebo group" - See Provigil (modafinil) at OffshoreRx1.com.
  • Link Between Inflammation, Cancer Confirmed - Science Daily, 6/2/08 - "Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer ... Researchers have long known that inflammation produces cytokines (immune response chemicals that encourage cell proliferation and suppress cell death), which can lead to cancer"
  • The Good And Bad Side Of Anti-cancer Compounds - Science Daily, 4/10/08
  • ROSIGLITAZONE AND RISK OF CANCER. A META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS - Diabetes Care. 2008 Mar 28 - "The incidence of malignancies was significantly lower in rosiglitazone-treated patients than in control groups (0.23[0.19-0.26] vs. 0.44[0.34-0.58] cases/100 patient*years" - Note:  I was taking rosiglitazone when I had my neck cancer.  Maybe that's one of the things that saved me.  I've since switched to pioglitazone (as an anti-aging measure to prevent AGEs, I don't have diabetes).
  • Strengthening The Tumor-fighting Ability Of T Cells - Science Daily, 3/24/08
  • The Association Between Statins and Cancer Incidence in a Veterans Population - J Natl Cancer Inst. 2008 Jan 8 - "After multivariable adjustment, a statistically significantly decreased risk of all cancers was also associated with increasing statin use"
  • Statin Drugs May Cut Cancer Risk - WebMD, 1/8/08 - "The veterans were followed for five years, on average. During that time, 9% of those taking statins were diagnosed with cancer, compared with 13% of those not taking statins, VA records show"
  • Eating More Red And Processed Meats Linked To Greater Risk For Bowel And Lung Cancer, Findings Suggest - Medscape, 12/10/07 - "people who eat a lot of red and processed meats have greater risk of developing colorectal and lung cancer than people who eat small quantities. They also indicate that a high red meat intake is associated with an increased risk of esophageal and liver cancer and that 1 in 10 colorectal and 1 in 10 lung cancers could be avoided if people reduced their red and processed meat intake to the lowest quintile"
  • Decrease in Cancer Risk for Pill Users - WebMD, 9/11/07 - "researchers found a 12% decreased risk of any cancer in oral contraceptive users compared with women who never used birth control pills"
  • Diabetes Drug Kills Some Cancer Cells - Science Daily, 8/14/07 - "Four weeks later, the p53-deficient tumors in mice treated with metformin were half the size of the p53 deficient tumors in control mice"
  • Stress May Help Cancer Cells Stay Alive - Doctor's Guide, 4/10/07 - "the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to cell death"
  • Gum Disease Ups Pancreatic Cancer Risk - WebMD, 1/16/07 - "subjects who reported gum disease were 64% more likely to have pancreatic cancer ... Michaud and colleagues suggest that long-standing gum infections trigger a body-wide immune response: inflammation. Inflamed tissues give off chemical signals that promote tumor growth"
  • Personalized Cancer Vaccine Improves Disease Free Survival - Doctor's Guide, 10/20/06 - "administration of the BiovaxID™ anti-cancer vaccine formulation resulted in long-lasting remission in NHL patients"
  • FDA OKs New Cancer Pain Drug - WebMD, 9/27/06
  • Cephalon Receives FDA Approval of Fentora(TM) (fentanyl buccal tablet) for the Management of Breakthrough Pain in Patients with Cancer - Doctor's Guide, 9/26/06
  • Blood Pressure Drugs Counter Cancer? - WebMD, 5/23/06 - "After crunching the numbers, the risk reduction in veterans taking ACE inhibitors was 53% for colon cancer, 52% for pancreatic cancer, and 46% for esophageal cancer"
  • Equivalent Of 2-4 Drinks Daily Fuels Blood Vessel Growth, Encourages Cancer Tumors In Mice - Science Daily, 4/4/06 - "the tumors of the mice that ingested alcohol ... were nearly twice as heavy compared to the mice that did not have alcohol ..."
  • Missing Link Ties Cancer to Chronic Infection - WebMD, 8/5/04 - "Infections provoke an immune response from the body. Part of this response is inflammation. Inflamed tissues swell, redden, and leak fluids full of chemical signals to the immune system"
  • Cholesterol Drugs May Prevent Cancer - WebMD, 6/2/03 - "Overall, taking statins reduces risk of developing cancer by 20%, but that protection increases to 36% for people who take statins for four years or more ... But the benefit stops about six months after the patient stops taking the drug" - Note:  Red yeast rice is a non-prescription statin.
  • New Cancer Vaccine Starves Tumors - WebMD, 11/5/02 - "Mice that were given the vaccine showed slowed blood vessel growth and were able to fend off tumors when injected with three different types of cancer cells (melanoma, colon, and lung)"
  • Closing In on Cancer, No magic bullet yet, but the drugs are getting smarter - Time Magazine, 5/21/01 - "current drug trials, even for new cancer treatments, are based on the old chemotherapy model. Success is measured by how much tumors shrink--or disappear--within a few days or weeks. Because angiogenesis inhibitors work on the blood vessels that feed tumors rather than on the tumors themselves, they usually take longer, sometimes as much as a few months, to show any effect"
  • Temodar (Temozolomide) Promising For A Variety of Cancers - Doctor's Guide, 5/15/01
  • New Generation Agent, ZD0473, Shows Promise In Resistant Tumors - Doctor's Guide, 5/15/01
  • Two New Vaccines Use the Immune System to Fight Cancer, Experimental Approach Boosts the Body's Ability to Fight Disease - WebMD, 5/14/01 - "It may be that one of the best weapons against cancer is already flowing in your veins -- immune cells called T-cells. Cancer researchers have been working for years to find a way to train these cells to fight cancer. And now two new studies suggest it may be possible to make a cancer vaccine using this 'in-house' force"
  • Leukemia pill [Gleevec] shows promise against stomach cancer - CNN, 5/14/01 - "A study of 148 GIST patients showed 59 percent went into remission, and the results were even better in those with the most common type of mutation"
  • New Cancer Drugs Disappointing - Intelihealth, 5/14/01
  • Doctors Encouraged By Cancer Drug - Intelihealth, 5/13/01 - "they expect the medicine to become a standard treatment for colon cancer and probably other tumors, as well ... The latest treatment, code-named IMC-C225, produced no cures, but it did shrink tumors by at least half in nearly one-quarter of patients with end-stage colon cancer"
  • Health Focus: Imagine Beating Cancer With A Pill - Intelihealth, 5/2/01
  • Giving the Immune System a Second Chance to Kill Cancers - WebMD, 4/30/01 - "What happens is we get tolerance. The [antitumor] arm of the immune system just ignores the tumor and lets it go. Our challenge is to overcome this ... take a patient's own tumor cells, irradiate them until they are dead, and -- very soon after autologous bone marrow transplant -- use them to vaccinate the person against the tumor"
  • A Peek at the Future of Cancer Therapy, New Drugs Aim at the Molecular Heart of Cancer - WebMD, 4/24/01 - "Far more impressive are results from a human study in Germany. In recently released results from this preliminary study, the drug was given to about 30 people with a wide range of cancers -- breast cancer, colon cancer, rectal cancer, melanoma, esophageal cancer, gastric cancer, and even cancer of the appendix. Most patients received 100 mg of the drug twice a day, every day. There was no toxicity. And over three to 28 weeks of observation, none of the cancers got worse"
  • Breast implants linked to brain, lung cancer - USA Today, 4/24/01 - "those who had received cosmetic breast implants were more than twice as likely to develop or die of brain cancer, the studies found"
  • Two-Step Titration Helps Switch Cancer Pain Patients From Intravenous To Transdermal Fentanyl - Doctor's Guide, 4/22/01 - "Slowly switching cancer patients from intravenous to transdermal fentanyl in a two-step approach prevents pain crises"
  • Number Of Cancer Drugs In The Pipeline Surges - Intelihealth, 4/12/01 - "Among the drugs are vaccines that trigger the immune system to attack cancer cells, monoclonal antibodies that seek out and destroy cancer cells, other antibodies that deliver a toxic payload to cancer cells, and small molecules that set off a reaction in cancer cells known as programmed cell death"
  • Cancer Pain Finally Gets Some Attention - Intelihealth, 4/11/01
  • Cancers Linked To Fat, Inactivity - Intelihealth, 4/6/01 - "Up to one-third of cancers of the colon, breast, kidney and digestive tract are attributable to too much weight gain and too little exercise"
  • Experimental Drug [Glivec] Cures Stomach Cancer, Report Says - Intelihealth, 4/6/01 - "a 55-year-old Finnish woman whose incurable stomach cancer had spread like a brushfire through her abdomen. Every time a growth was surgically removed, several would erupt in its place. Her frustrated doctors at Helsinki University concluded she was beyond the reach of chemotherapy and radiation ... Within two weeks the tumors began to shrink ... the Finnish woman is in good health, living a normal life despite having a cancer that previously was always lethal"
  • Guidelines released for cancer pain treatment - CNN, 4/4/01
  • The Future of Cancer Therapy Is Specific, Drugs Will Target Only Molecules Involved in Cancer - WebMD, 4/4/01
  • Autologous Hapten-Dinitrophenyl Offered As New Approach To Cancer Therapy - Doctor's Guide, 3/30/01 - "hapten, dinitrophenyl, appears to be comparable to high dose interferon for the treatment of a number of cancers ... there is no apparent reason why this therapeutic approach should not be offered to a larger number of patients, or to its development as a standard cancer therapy"
  • 'Blood Biopsies' Can Replace Some Cancer Operations, Docs Turn to Blood Draws to Detect Recurrence, Assess Treatment - WebMD, 3/29/01
  • New Technique Lets Doctors Make Quicker, Better Treatment Decisions - WebMD, 3/26/01
  • Heparin May Reduce Cancer's Spread - WebMD, 3/12/01 - "This study on mice shows that (injectable) heparin prevents platelets from sticking to the cancer cells, making them more vulnerable to the immune system's natural cleanup action"
  • Cancer pill (Glivec) speeds through testing - CNN, 3/1/01 - "In 88 percent of patients their white blood cell counts fell to normal levels. Almost half the patients had what's called a cytogenic response -- the genetic defect for the disease was reduced or could not be seen."
  • Studies link lymph vessels to cancer growth - CNN, 2/1/01- "Preventing the growth of lymph vessels, not just blood vessels, may be a way to doctors to treat cancer, according to three new studies on human cancer growth cell in mice."
  • Cancer Prevention Trump Card Clearly in Your Hands, Environmental Factors Play Bigger Role Than Heredity - WebMD, 7/12/00 - "Most cancer is caused by environmental and lifestyle factors such as diet, smoking, drinking alcohol, and being overweight"