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Home > Anti-aging Research > B Vitamins.

B Vitamins

Specific Recommendations:

• iHerb or Vitacost folic acid products.
• iHerb or Vitacost Vitamin B12 products.
• Biotin products at iHerb
• Biotin products at Vitacost
• Vitamin Shoppe

CME/CEM:

• Older Adults May Need B12 Dose More Than 200 Times the RDA to Normalize Mild Vitamin Deficiency - Medscape, exp. 5/27/06
• Health Benefits of Folic Acid - PowerPak.com, exp. 11/15/05

General Information:

• Who should take a B-complex multivitamin? - drugstore.com
• B-Vitamins and Heart Disease - thenutritionreporter.com

Other News:

• Folate linked to lower colorectal cancer risk: Study - Nutra USA, 7/6/09 - "A possible explanation for the contradictory results of studies with the vitamin and colorectal cancer may be the difference between the synthetic and natural forms of the vitamin. “The fact that folic acid, which is not a naturally occurring form of the vitamin, is used by food and pharmaceutical industries for fortification and supplementation is potentially of importance,” wrote Tufts University’s Mason in Nutrition Reviews ... On passage through the intestinal wall, folic acid is converted to 5-methyltetrahydrofolate, the naturally circulating form of folate. However, some studies have suggested that oral doses of folic acid in high doses may overwhelm this conversion pathway, leading to measurable levels of folic acid in the blood ... There has been some concern that this oxidized, non-substituted form of folate might feasibly be detrimental because it is not a naturally occurring co-enzymatic form of the vitamin" - [Abstract]
• Metformin Linked to B12 Deficiency - WebMD, 6/8/09 - "40% of type 2 diabetes patients using metformin had vitamin B12 deficiency or were in the low-normal range for the essential vitamin. And 77% of metformin users with vitamin B12 deficiency also had peripheral neuropathy, a common form of nerve damage associated with type 2 diabetes" - See B-12 products at iHerb.
• Folic acid in pregnancy better than thought - MSNBC, 6/1/09 - "Baby-protecting folic acid is getting renewed attention: Not only does it fight spina bifida and some related abnormalities, new research shows it also may prevent premature birth and heart defects"
• Folic Acid Effective In Preventing Congenital Heart Defects, Canadian Research Shows - Science Daily, 5/19/09
• B6 may slash colorectal cancer risk: Harvard study - Nutra USA, 5/5/09 - "increased intakes of vitamin B6 from dietary and supplements may reduce the risk of colorectal cancer by over 20 per cent (Cancer Epidemiol Biomarkers Prev., Vol. 17, pp. 171-182)"
• Folic Acid May Help Treat Allergies, Asthma - Science Daily, 4/30/09 - "People with higher blood levels of folate had fewer IgE antibodies, fewer reported allergies, less wheezing and lower likelihood of asthma ... People with the lowest folate levels (below 8 nanograms per milliliter) had 40 percent higher risk of wheezing than people with the highest folate levels (above 18 ng/ml) ... People with the lowest folate levels had a 30 percent higher risk than those with the highest folate levels of having elevated IgE antibodies, markers of allergy predisposition ... Those with the lowest folate levels had 31 percent higher risk of atopy (allergic symptoms) than people with the highest folate levels ... Those with lowest folate levels had 16 percent higher risk of having asthma than people with the highest folate levels" - See folic acid at iHerb.
• Health Benefits, Consequences Of Folic Acid Dependent On Circumstances - Science Daily, 4/1/09 - "Under most circumstances, adequate intake of folate appears to assume the role of a protective agent against cancer, most notably colorectal cancer. However, in select circumstances in which an individual who harbors a pre-cancerous or cancerous tumor consumes too much folic acid, the additional amounts of folate may instead facilitate the promotion of cancer"
• Folic Acid May Raise Prostate Cancer Risk - WebMD, 3/10/09 - "Men in the study who took high doses of the vitamin had a more than twofold increase in prostate cancer risk, compared to men who did not take folic acid supplements"
• Folate Deficiency May Triple Dementia Risk in the Elderly - Medscape, 3/3/09 - "individuals who were folate deficient at study outset were 3.5 times more likely to develop dementia" - See folic acid products at iHerb.
• Can B Vitamins Lower Risk of Blindness? - WebMD, 2/23/09 - "researchers randomly assigned more than 5,000 women over 40 without signs of age-related macular degeneration to take a combination of 2.5 milligrams of folic acid, 50 milligrams of vitamin B6, and one milligram of vitamin B12 or a placebo every day ... The results showed that women taking the B vitamin supplements had a 34% lower risk of any AMD and a 41% lower risk of AMD with vision loss than the placebo group ... the benefits of the vitamin combination in preventing AMD appeared to emerge about two years after treatment began"
• B Vitamins May Cut Stroke Risk - WebMD, 2/20/09 - "people who took the vitamins were 25% less likely to suffer a stroke over the study period than those who took placebo"
• Vitamin B12 identified As An Effective Canker Sore Therapy, Study Suggests - Science Daily, 2/10/09 - "a nightly dose of vitamin B12 is a simple, effective and low risk therapy to prevent Recurrent Aphthous Stomatitis (RAS), better known as "canker sores." ... received either a dose of 1,000 mcg of B12 by mouth at bedtime or a placebo ... the duration of outbreaks, the number of ulcers, and the level of pain were reduced significantly at five and six months of treatment with vitamin B12, regardless of initial vitamin B12 levels in the blood. During the last month of treatment a significant number of participants in the intervention group reached 'no aphthous ulcers status' (74.1% vs 32.0%; P < .01)." - See vitamin B12 products a iHerb.
• Vitamin B1 Could Reverse Early-stage Kidney Disease In Diabetes Patients - Science Daily, 12/8/08 - "the team show 300 mg of thiamine taken orally each day for three months reduced the rate of albumin excretion in type 2 diabetes patients. The albumin excretion rate was decreased by 41% from the value at the start of the study. The results also showed 35% of patients with microalbuminuria saw a return to normal urinary albumin excretion after being treated with thiamine ... were randomly assigned a placebo or 3 x 100mg tablets of thiamine a day for three months"
• Cyanocobalamin May be Beneficial in the Treatment of Recurrent Aphthous Ulcers Even When Vitamin B12 Levels Are Normal - Am J Med Sci. 2008 Nov;336(5):379-382. - "recurrent aphthous ulcers (RAUs) ... vitamin B12 (cobalamin) ... cobalamin normal group (CNG) ... A significant increase in cobalamin levels was observed after cyanocobalamin treatment in both groups. A significant decrease in aphthous ulcer frequency was also concurrently observed. 96% of the patients showed good response to replacement treatment, 4% of the study population did not respond to the treatment ... Cyanocobalamin treatment maybe beneficial for patients with RAU even when serum cobalamin levels are normal. We suggest that higher serum cobalamin levels should be attained in patients with RAU for mucosal protection" - See iHerb vitamin B12 products.
• Form of Vitamin B3 May Help Alzheimer's - WebMD, 11/4/08 - "Researchers from the University of California, Irvine dissolved nicotinamide in drinking water and fed it to mice with Alzheimer's. The researchers found that nicotinamide prevented mental deficits in mice with Alzheimer's. It also seemed to improve short-term memory of mice without Alzheimer's" - [Science Daily} - See nicotinamide at iHerb.
• Folic Acid Flops in Cancer Study - WebMD, 11/4/08
• Aging - Lack of B12 Linked to Brain Shrinkage - New York Times, 9/8/08 - "The group with the lowest levels of vitamin B12 lost twice as much brain volume as those with the highest levels" - See iHerb vitamin B12 products.
• Vitamin B12 Boasts Brain Benefits - WebMD, 9/8/08 - "None of the people in the study had a vitamin B12 deficiency ... When the researchers compared the results, they found that people who had higher vitamin B12 levels were six times less likely to experience brain shrinkage compared with those who had lower levels of the vitamin in their blood"
• B-vitamin Deficiency May Cause Vascular Cognitive Impairment - Science Daily, 9/2/08 - "Mice fed a diet deficient in folate and vitamins B12 and B6 demonstrated significant deficits in spatial learning and memory compared with normal mice"
• New Evidence On Folic Acid In Diet And Colon Cancer - Science Daily, 9/1/08 - "folate depletion caused increased DNA damage and a cascade of other biological changes linked to an increased cancer risk" - See folic acid products at iHerb.
• Higher Plasma Folate Associated With Lower Colorectal Cancer Mortality - Medscape, 8/5/08 - "In a study that was undertaken to address concerns that folic acid supplements promote tumor growth in patients with a history of colorectal cancer, researchers found that in fact, higher plasma folate levels are associated with a lower risk of colorectal cancer-specific and overall mortality"
• Trends Of Vitamin B6 Status In US Population Sample Identified - Science Daily, 5/20/08 - "Across the study population, we noticed participants with inadequate vitamin B6 status even though they reported consuming more than the Recommended Daily Allowance of vitamin B6, which is less than 2 milligrams per day ... Three quarters of the women who reported using oral contraceptives, but not vitamin B6 supplements, were vitamin B6 deficient"
• Brief, High Doses Of Folate -- B Vitamin -- Blunt Damage From Heart Attack - Science Daily, 3/27/08 - "Long known for its role in preventing anemia in expectant mothers and spinal birth defects in newborns, the B vitamin folate, found in leafy green vegetables, beans and nuts has now been shown to blunt the damaging effects of heart attack when given in short-term, high doses to test animals ... a high dose of folic acid for humans comparable to that given the rats would require an average-size adult to swallow more than 200 one-milligram pills per day, "an impractical and unrealistic regimen, even if the body excretes the excess."" - I debated whether to publish this.  It is a ridiculous amount.
• Vitamin B6 and Homocysteine Changes Seen in Women With Rheumatoid Arthritis - Medscape, 3/25/08 - "those with rheumatoid arthritis are deficient in vitamin B6 and have elevated levels of homocysteine ... The vitamin B6 deficit appears to be the result of altered metabolism, not reduced dietary intake ... dietary intake of B vitamins is not decreased in rheumatoid arthritis patients, yet they still show a deficit of vitamin B6. Consistent with this finding, rheumatoid arthritis was also associated with increased levels of homocysteine. None of the subjects in the study were using B vitamin supplements ... Individuals with rheumatoid arthritis may need to get more B vitamins through diet, supplements, or fortified foods"
• Dads-to-Be May Need Folate, Too - WebMD, 3/20/08 - "Sperm with chromosomal abnormalities called aneuploidy were rare for all of the men, but they were 18% to 30% rarer in men who reported high folate or folic acid intake" - See folic acid products at iHerb.
• Folate Deficiency Associated With Tripling Of Dementia Risk, Study Shows - Science Daily, 2/5/08 - "Folate deficiency is associated with a tripling in the risk of developing dementia among elderly people" - See iHerb folic acid products.
• Testosterone Reduces Visceral Fat Gain in Nonobese Older Men - Medscape, 2/1/08
• Large Study Links Folic Acid Supplementation With Reduced Risk Of Preeclampsia During Pregnancy - Science Daily, 1/23/08 - "preeclampsia occurred in 2.2 per cent of women who took multivitamins containing folic acid compared to 5.1 per cent of women who did not"
• Vitamin B6 may slash colorectal cancer risk - Nutra USA, 1/17/08 - "High vitamin B6 intakes were reported to reduce the risk of colorectal cancer by 19 per cent. The protective effect was found to be higher among 55-year-old individuals (1,001 cases compared to 1,010 controls)" - [Abstract]
• CDC to Young Women: Take Folic Acid - WebMD, 1/10/08 - "All women, especially younger women ages 18-24 years, need to consume 400 micrograms of folic acid daily through supplements, fortified foods, or both in addition to a folate-rich diet to prevent serious birth defects"
• Folic Acid and Stroke--Finally Some Good News - Medscape, 1/3/08 - "the results of this trial were notable for a 25% relative reduction in the risk for stroke among participants receiving folate and B vitamins vs placebo"
• Vitamin B-12 Function May Be Diminished By Excessive Folate - Science Daily, 12/21/07 - "homocysteine and methylmalonic acid are at much higher levels in individuals who have a combination of vitamin B12 deficiency and high blood folate levels than in individuals who are also vitamin B12 deficient but have normal folate levels"
• Excess folate worsens B12 deficiency effects: study - Nutra USA, 12/19/07 - "Finding that the combination of high blood folate levels and low vitamin B12 status is associated with even higher levels of these compounds is a strong indication that the high folate is interfering with the action of these B12-containing enzymes, thus resulting in the exacerbation or worsening of the vitamin B12 deficiency"
• Folate may reduce depression symptoms for men, says study - Nutra USA, 12/7/07 - "male subjects with the highest average intake (235 micrograms per 100 kcal) were 50 per cent less likely to have depressive symptoms than men with the lowest average intake (119 micrograms per 100 kcal)" - [Abstract] - See iHerb folic acid products.
• Increased B12 levels could ward off dementia - Nutra USA, 11/16/07 - "The longitudinal cohort study followed 1648 participants for 10 years, and found a doubling in holotranscobalamin (holoTC) concentrations was associated with a 30 per cent slower rate of cognitive decline ... increased levels of the amino acid homocysteine doubled the risk of dementia or cognitive impairment" - [Abstract] - See iHerb vitamin B12 products.
• Folic Acid in Preconceptual Period May Have a Preventive Effect on Congenital Heart Disease - Doctor's Guide, 11/6/07 - "The recent increase in folic acid intake has resulted in a decrease in the prevalence of infants born with severe congenital heart disease (CHD), supporting the idea that folic acid taken preconceptually may prevent CHD"
• Riboflavin boosts folate's colorectal cancer protection - study - Nutra USA, 10/29/07
• Mesalamine, Folic Acid Each Cut Colorectal Cancer in Patients With Inflammatory Bowel Disease - oncologystat.com, 10/24/07 - "Patients who took at least 1 mg of folic acid daily also had about a 90% cut in their CRC incidence during follow-up, compared with the controls" - See iHerb folic acid products.
• Folic Acid Lowers Blood Arsenic Levels, Study Shows - Science Daily, 10/8/07 - "treatment with 400 micrograms a day of folic acid, the U.S. recommended dietary allowance, reduced total blood arsenic levels in the study population by 14 percent"
• Pantethine: A Better Cholesterol Treatment? - Dr. Weil, 10/8/07
• Increased folate may slash breast cancer risk - Nutra USA, 8/9/07 - "women in the highest average intake group (456 micrograms of folate per day) had a 44 per cent lower risk of invasive breast cancer than women in the lowest average intake group (160 micrograms of folate per day)"  [Abstract]
• Vitamin B1 Deficiency Key To Vascular Problems For Diabetic Patients, Study Suggests - Science Daily, 8/7/07 - "thiamine concentration in blood plasma was decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients ... the decreased availability of thiamine in vascular cells in diabetes was linked to a marker of microvascular and macrovascular complications"
• Too Much (Good-for-You) Folate Might Be Really Bad - US News and World Report, 8/5/07 - "Cells use folate to keep their genetic software—their DNA—in good repair and to make copies of DNA when they divide. DNA is less likely to develop the sorts of defects that lead to cancer when it's well maintained, so folate may lower cancer risk in people who are healthy. But once a defect is present, experts theorize, replicating cancer cells hungrily gobble up folate to make new copies of their malevolent DNA"
• Selective Vitamin Supplementation May Improve Cognitive Functions - Clinical Psychiatry News, 6/07 - "Supplementation with vitamins B6 and B12 and folate in younger to middle-aged adults improves motor speed and sequencing ability on neuropsychological tests ... participants who took the supplements performed the task significantly faster than they had a month before, which indicated increased motor speed. The placebo group patients had no improvement on this test ... Among people who entered the trial with vitamin B12 levels on the low end of the normal range, those who received supplementation significantly improved their performance on the Trail Making Test Parts A and B. Part B includes some assessment of executive function"
• Folate may reduce liver damage study - Nutra USA, 7/6/07 - "higher red blood cell folate levels were associated with a 67 per cent reduced risk of liver cancer" - [Abstract] - See iHerb folic acid products.
• Folic acid 'reduces stroke risks' - BBC News, 5/31/07 - "They found the vitamin reduced the relative risk of stroke by an average of 18% ... An even greater risk reduction - 30% - was seen when the treatment lasted more than 36 months"
• Folic Acid May Lower Stroke Risk - WebMD, 5/31/07
• High Folate Intake May Lower AD Risk - Clinical Psychiatry News, 2/07 - "The risk of AD decreased with increasing intake of folate but not of vitamins B6 or B12"
• Folate And B12 May Influence Cognition In Seniors - Science Daily, 2/12/07 - "People with normal vitamin B12 status performed better if their serum folate was high ... But for people with low vitamin B12 status, high serum folate was associated with poor performance on the cognitive test ... For seniors, low vitamin B12 status and high serum folate was the worst combination"
• Folic acid effects two-faced depending on B12 levels, says study - Nutra USA, 1/31/07 - "In this study of older Americans in the age of folic acid fortification, we found direct associations between high serum folate and both anaemia and cognitive impairment in subjects with low vitamin B12 status ... Among subjects with normal vitamin B12 status, on the other hand, high serum folate was associated with protection from cognitive impairment"
• Folic Acid Improves Cognitive Performance in Older Adults - Medscape, 1/19/07 - "Patients were randomized to either placebo or 800 µg daily of folic acid for 3 years ... 3 years of treatment with folic acid conferred on individuals resulted in the performance of someone 4.7 years younger for memory, 1.7 years younger for sensorimotor speed, 2.1 years younger for information processing speed, and 1.5 years younger for global cognitive function"
• Higher Folate Levels Linked To Reduced Risk For Alzheimer's Disease - Science Daily, 1/9/07 - "Folate, vitamin B12 and vitamin B6, are important in the body's processing of homocysteine--therefore, deficiencies in these nutrients increase homocysteine levels and may contribute to cardiovascular disease, stroke and dementia ... When the individuals were divided into four groups based on the total level of folate they took in through food and supplements and the analysis was adjusted for patient characteristics, comorbid diseases and B12 and B6 intake, the risk of Alzheimer's disease was lower in the groups with higher intake" - See iHerb or Vitacost folic acid products.
• Folic Acid May Slow Hearing Loss - WebMD, 1/2/07 - "Half the study participants got strong folic acid supplements -- 800 micrograms per day, about twice what one would get in a multivitamin pill ... After three years, those who got folic acid pills had less low-frequency hearing loss than did placebo recipients"
• Poor Athletic Performance Linked To Vitamin Deficiency - Science Daily, 12/27/06 - "Current national B-vitamin recommendations for active individuals may be inadequate, and athletes who follow the recommended daily allowances set by the U.S. government may be receiving lower amounts of nutrients than there bodies need"
• Research Affirms the Benefits of Combination of Chromium Picolinate and Biotin for Improving Blood Sugar in People with Type 2 Diabetes - Doctor's Guide, 12/20/06 - "The 30-day study examined 36 overweight or obese poorly controlled patients with type 2 diabetes taking Diachrome who were already receiving oral anti-diabetic drug(s). The results also showed a significantly greater reduction in the total area under the curve for glucose (AUCg) during the oral glucose tolerance test (OGTT) for the treatment group (mean change -9.7%) compared with the placebo group (mean change +5.1%)"
• Use Folic Acid To Cut Heart Disease, Say Experts - Science Daily, 11/28/06 - "The scientific evidence is strong enough to justify using folic acid as a cheap and simple way of reducing heart disease and strokes"
• Folic Acid Modestly Protects Against Cardiovascular Events - Medscape, 11/27/06 - "the combined evidence from cohort, genetic, and randomized controlled studies is indeed strong enough to support a modest protective effect of this nutrient"
• Low Folate Diets Found To Increase Risk Of Colorectal Cancer - Science Daily, 11/14/06 - "None of the mice fed a control diet developed tumours whereas 1 in 4 mice on the folate-deficient diet developed at least one tumour"
• Encouraging Results For Folic Acid As A Cancer Prevention Drug - Science Daily, 6/12/06 - "31 of 43 patients with the precancerous laryngeal lesion called leucoplakia demonstrated 50 percent or greater reduction in the lesion size after six months of taking folate supplements. In 12 of 31 responders, there was no evidence of the original lesion ... Folate deficiency is the most common vitamin deficiency in the United States"
• Vitamin B6 May Help Prevent Colorectal Cancer - Medscape, 6/10/06 - "There was an inverse association between vitamin B6 intake and colorectal cancer, with the relative risk (RR) for the highest quintile vs the lowest quintile being 0.66 ... Vitamin B6 may have a role in colorectal cancer prevention through reduction of oxidative stress and synthesis of a form of folate required for DNA repair, synthesis, and methylation"
• Does your heart need more vitamin B? - MSNBC, 6/2/06
• Folic Acid May Cut Stroke Deaths - WebMD, 3/13/06 - "In the U.S. and Canada, stroke deaths declined at a faster rate after mandatory folic acid (also known as folate) fortification"
• Treating Hair Loss Naturally - WebMD - "Daly says he routinely recommends up to 3 mg of biotin daily for his hair loss patients, while Lessman developed a healthy hair, skin, and nails product containing 2 mg of biotin per daily dosage, which he believes is the minimum for healthy hair"
• Thiamin Deficiency Common in Hospitalized Heart Failure Patients - Doctor's Guide, 1/13/06 - "Among patients hospitalized with heart failure, about one in three has deficient levels of thiamin ... a relatively small dose of thiamin from a multi-vitamin was protective against developing thiamin deficiency"
• Folic Acid to Boost Memory? - Dr. Weil, 12/13/05 - "those who took the folic acid had memory scores equal to people five and a half years younger"
• Do you get enough vitamin B-12? - MSNBC, 11/18/05 - "Now, a new concern about vitamin B-12 has arisen. It seems that adults over the age of 50 may have a reduced ability to absorb it ... A high intake of folate from fortified grains can hide the changes in red blood cells that show a lack of vitamin B-12" - See iHerb or Vitacost Vitamin B12 products.
• Veggies May Keep an Aging Brain Sharp - WebMD, 9/28/05
• Leafy Green Vegetables May Help Keep Brains Sharp Through Aging - Science Daily, 9/26/05 - "men who obtained more folate in their diets showed significantly less of a decline in verbal fluency skills over the course of three years than did men with lower dietary folate intake ... High folate levels, both in the diet and in the blood, also appeared to be protective against declines in another category of cognitive skills known as spatial copying"
• Folates More Effective In Limiting Alzheimer's Disease Risk Than Antioxidants, Other Nutrients - Science Daily, 8/17/05 - "folates appear to have more impact on reducing Alzheimer's risk than vitamin E, a noted antioxidant, and other nutrients considered for their effect as a brain-aging deterrent" - See iHerb or Vitacost folic acid products.
• Folate May Reduce Risk of Alzheimer's Disease - WebMD, 8/15/05 - "older adults whose total folate intake (diet and supplement) equaled or exceeded the 400 microgram RDA reduced their chances of developing Alzheimer's disease by 55%" - See iHerb or Vitacost folic acid products.
• Supplemental Chromium Picolinate and Biotin Appear to Decrease Blood Glucose and Lipid Levels in Type 2 Diabetics: Presented at ADA - Doctor's Guide, 6/17/05 - "Our most important finding is that chromium picolinate and biotin help to decrease hemoglobin A1c [HbA1c] values in poorly controlled diabetics ... 600 mcg chromium picolinate and biotin 2 mg/per day" - See iHerb or Vitacost biotin products.
• Vitamin B6 May Help Prevent Colorectal Cancer - Medscape, 6/10/05 - "those in the highest quintile had a 34% lower risk of colorectal cancer (multivariate rate ratio"
• High vitamin B intake cuts risk of colorectal cancer - Nutra USA, 6/6/05
• Vitamin B-6 May Help People Avoid Colon Cancer - WebMD, 5/3/05 - "The risk of colorectal cancer was 44% lower for the women with the highest blood level of vitamin B-6 compared with women with the lowest level of vitamin B-6"
• Fight Osteoporosis: Bone Up On B12 - Science Daily, 4/23/05 - "This study suggests adequate vitamin B12 intake is important for maintaining bone mineral density"
• Folate and Vitamin B12 Prevent Hip Fracture in Stroke Patients - Medscape, 3/25/05 - "The magnitude of benefit is similar to that found in trials of alendronate and raloxifene, with considerably less potential risk. The fact that BMD did not change suggests the benefit derives from quality, rather than quantity, of bone"
• B Vitamins (including Thiamin, Niacin, B-6, B-12, Riboflavin and Folate) review - ConsumerLab.com, 4/5/05
• Folic acid: It's not just for your baby’s health - MSNBC, 4/4/05 - "The younger group of women (ages 25 to 42) who consumed 1000 micrograms of folic acid through foods and supplements had a 46 percent decrease in their risk of developing hypertension as compared to those women who consumed less than 200 micrograms ... older group of women (ages 30 to 55) 1000 micrograms of folic acid was found to decrease risk of developing hypertension to a lesser extent — 18 percent" - See iHerb or Vitacost folic acid products.
• Folic Acid and Vitamin B12 Decrease Risk of Hip Fracture in Stroke Patients - Doctor's Guide, 3/1/05 - "Patients who took folic acid and vitamin B12 after their stroke had a reduced risk of hip fracture compared to patients who took placebo"
• Preventing Heart Disease and Depression with High-Dose Folic Acid - Life Extension Magazine, 3/05 - "High-dose folic acid—up to 5000 mcg daily—is a scientifically substantiated and safe nutritional approach to achieving optimal health in men and women who want to prevent or reverse chronic illness. With demonstrated benefits in reducing cardiovascular risk factors, preventing and enhancing treatment outcomes in depression, and preventing cancer, folic acid is highly indicated as a therapeutic ally for men and women of all ages"
• Folic Acid May Prevent Hypertension in Addition to Reducing the Risk of Birth Defects - Doctor's Guide, 2/24/05 - "younger women who consumed at least 1,000 micrograms per day of total folic acid (dietary plus supplemental) had a 46 percent decreased risk of hypertension, compared with those who consumed less than 200 micrograms a day of total folic acid. Older women with high total folic acid intake also had an 18 percent reduced risk of hypertension"
• Folate Lowers Risk of High Blood Pressure - WebMD, 10/11/04 - "Young women with very low dietary folate who got their folate from vitamin supplements had a 39% lower risk of high blood pressure compared with young women who did not take folate supplements"
• High Vitamin B12 Levels May be Linked to Better Treatment Outcome for Major Depressive Disorder - Doctor's Guide, 1/5/04 - "Low levels of folate have also been associated with a poor response to antidepressive therapy ... patients with greater HDRS responses had higher vitamin B12 levels both at baseline (r = 0.39, P < .001) and at 6 months ... The positive relationship between higher vitamin B12 levels and improved HDRS score was also confirmed by linear regression analysis" - [Abstract]
• Vitamin B12 might be an answer for depression - Time Magazine, 12/15/03 - "the patients who responded best to treatment were those who had higher concentrations of B12 in their blood"
• Folic Acid Cuts Children's Cancer - WebMD, 9/29/03 - "neuroblastoma rates dropped by 60% since folic acid was added to flour"
• The Chromium Connection - Natural Foods Merchandiser, 9/03 - "The body requires certain nutrients to control glucose metabolism, especially chromium, zinc and vitamins B and C" - See iHerb or Vitacost chromium products.
• Cancer Fighter: Vitamin B-6 - Physician's Weekly, 8/11/03 - "Washington State University researchers suggest that consuming more vitamin B-6 can ward off cancer. The vitamin converts folate to a form the body can use to produce thymine, a component of DNA"
• Higher Folate Levels Correlate with Improved Outcome for SSRI-Treated Geriatric Patients - Doctor's Guide, 7/16/03 - "Geriatric patients who are treated with the selective serotonin reuptake inhibitor (SSRI) sertraline appear to experience greater improvement in depression if they have higher than normal folate levels at the start of therapy"
• Vegetarian Diet and B12 Deficiency - WebMD, 6/18/03 - "92% of the vegans they studied -- those who ate the strictest vegetarian diet, which shuns all animal products, including milk and eggs -- had vitamin B12 deficiency. But two in three people who followed a vegetarian diet that included milk and eggs as their only animal foods also were deficient"
• Low Folate Concentrations Associated With Depression - Doctor's Guide, 5/2/03 - "Physically healthy people who are depressed have detectably lower folate status than those who are not depressed" - See iHerb or Vitacost folic acid products.
• Adding Folates Alters Methotrexate Treatment In Rheumatoid Arthritics - Doctor's Guide, 4/21/03 - "The researchers found the addition of folates to MTX treatment was strongly linked with lack of hepatotoxicity"
• B-Vitamins Prove Effective In Relieving Chronic Pain - Intelihealth, 4/10/03 - "B-vitamins, such as thiamin (B1), pyridoxine (B6), and cyanocobalamin (B12), have been proven to be clinically effective in treating various painful conditions such as lumbago, sciatica, trigeminal neuralgia, facial paralysis and optic neuritis as acting as an analgesia (pain reliever)"
• Folate, Vitamin B6 Reduce Breast Cancer Risk Among Moderate Drinkers - WebMD, 3/4/03 - "They found women with the highest folate levels were 27% less likely to have breast cancer than those with the lowest folate levels. And the reduction in breast cancer risk was much greater among women who drank about one glass of wine or a cocktail per day. These moderate drinkers with high folate levels were 89% less likely to develop breast cancer than those who drank less than one drink per day ... Women with high levels of vitamin B6 also had about a 30% lower risk of breast cancer than those with low levels of this nutrient. Although high levels of vitamin B12 seemed to protect premenopausal women against breast cancer, the effect was not found among postmenopausal women"
• Alzheimer's Disease and Dementia: Vitamins Can Help Prevent - WebMD, 2/28/03 - "High levels of a substance in the blood called homocysteine tops the list of potentially new risk factors for heart disease, stroke, and now dementia. A new study suggests that high homocysteine levels are linked with mental declines associated with Alzheimer's disease in elderly people ... High homocysteine levels can be treated very easily with vitamins, including folate, niacin, and B-12"
• Low Levels of Serum Vitamin B May Be Related to Helicobacter Pylori Infection - Doctor's Guide, 2/14/03 - "Of 25 subjects with vitamin B >145-180 pg/mL, 92% were seropositive ... Eighty-nine percent of the 47 subjects with vitamin B greater than 180-250 pg/mL were found to be seropositive compared with 51%, 31 out of 61, of subjects with B less than 250 pg/mL" - [abstract] - See the abstract.  I think they are talking about vitamin B12.
• Canadian Folic Acid Supplementation Cuts in Half the Rate of Neural Tube Defects - Doctor's Guide, 12/19/02 - "A Canadian public-health initiative to enrich cereal grain foods with folic acid has halved the prevalence of neural-tube defects among both unborn and newborn children"
• Folic Acid Improves Endothelial Function And Blood Pressure In Smokers - Doctor's Guide, 12/18/02 - "Smokers were randomly assigned to receive either 5 milligrams of folic acid or placebo every day ... Mean blood pressure was significantly reduced from 88 ± 2 to 83 ± 1 mmHg in those patients who received supplementation" - Seems like they could have tested non-smokers for the same effect while they were at it.  5 points is probably half of what you'd get from the standard dose of most anti-hypertensive medications. - Ben
• Mechanisms Differ Between Depression and Either Vitamin B12 Or Folate - Doctor's Guide, 12/10/02 - "hyperhomocysteinemia, vitamin B12 deficiency and, to a lesser extent, folate deficiency all were related to depressive disorders"
• I’ve heard that receiving weekly B-12 shots can help your metabolism. Any truth to it? - Dr. Weil, 12/4/02
• Argument Strengthens For Folic Acid To Reduce Homocysteine Level - Doctor's Guide, 11/26/02 - "A decrease in serum homocysteine of 3 micromol/l, which can be achieved by a daily intake of about 0.8 mg folic acid, should reduce the risk of ischaemic heart disease by 16 percent, deep vein thrombosis by 25 percent, and stroke by 24 percent" - See iHerb or Vitacost folic acid products.
• Folic Acid for Your Heart - WebMD, 11/22/02 - "By increasing folic acid intake and thus decreasing homocysteine, the researchers say the risk of heart disease would drop by 16%, blood clots in the legs by 25%, and stroke by 24%" - See iHerb or Vitacost folic acid products.
• Folic Acid Could Prevent Heart Disease - Intelihealth, 11/22/02
• More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy for reducing Alzheimer's disease (AD) risk that includes low fat intake and high consumption of fish and antioxidants, along with vitamin E, folic acid, and vitamins B6 and B12 supplements"
• Low Folic Acid Linked to Miscarriage - WebMD, 10/15/02
• B Vitamins Protect Heart Patients: The Best Evidence Yet - New Hope Natural Media, 9/12/02
• Folic Acid May Have Benefits for Smokers - Doctor's Guide, 9/13/02 - "randomised to four weeks of folic acid 5 mg/day or placebo ... Results showed that folic acid reduced homocysteine concentrations (10.8+/-0.6 versus 7.9+/-0.5 µmol/L, p<0.001) and there was a significant reduction in blood pressure (mean BP 88+/-2 versus 83+/-1 mmHg, p<0.01) ... Benefits also seem to be largely independent of the lowering of homocysteine concentrations"
• Homocysteine-Lowering Therapy [folic acid, vitamin B12 and vitamin B6] Improves Revascularisation, Angioplasty Outcome - Doctor's Guide, 8/28/02
• Natural Remedies for Osteoarthritis: Now, More than Ever - New Hope Natural Media, 8/15/02 - "Some doctors recommend niacinamide (vitamin B3)"
• Older Vegetarians Should Take Extra Vitamin B12 - Doctor's Guide, 8/7/02 - "Forty-two percent of participants had definite vitamin B12 deficiency, defined as vitamin B12 level less than 150 pmol/L and MMA ³ 0.4 µmol/L. Another 32.8 percent of the women had possible vitamin B12 deficiency" - See iHerb or Vitacost Vitamin B12 products.
• Folate Supplements May Help Restore Endothelial Function In Type 2 Diabetics - Doctor's Guide, 8/1/02
• New Views on Atherosclerosis - Life Extension Magazine, 8/02 - "A drug company has patented a product called FOLTX that cardiologists are now prescribing to their patients for the purpose of lowering homocysteine. Each tablet of FOLTX contains: 2.5 mg of folic acid, 1.0 mg of vitamin B12, 25 mg of vitamin B6.  The cost for 90 tablets of FOLTX from www.drugstore.com is $38.08—or about double the retail price of these same potencies of vitamins when purchased in a health food store"
• Folic Acid Fights Colon Cancer - WebMD, 7/19/02
• Folic Acid Supplement Reduces Cell Proliferation In High Risk Colorectal Cancer Patients - Doctor's Guide, 7/18/02 - "Patients at high risk of colorectal cancer could cut their risk dramatically with a daily supplement of 2 mg of folic acid" - See iHerb or Vitacost folic acid products.
• Higher Folate Levels May Help Protect Against Vascular Disease in Children with Diabetes - Doctor's Guide, 7/18/02 - "High folate levels may protect children with type I diabetes from vascular damage"
• Dietary Folate May Reduce Stroke Risk - Medscape, 7/5/02
• Biotin Supplement Needed During Pregnancy - New Hope Natural Media, 6/20/02 - "Preliminary studies have suggested that biotin in large amounts (such as 5 to 16 mg per day) can help control blood sugar levels or improve nerve damage in diabetics. In a study of individuals with dry, splitting nails, supplementation with 2.5 mg of biotin per day improved the quality of the nails in 63% of those treated. Improvement was seen after an average of two months, although some individuals did not see results until they had taken biotin for four months." - Note:  Biotin is expensive so most multi's cut you short on that B vitamin.
• Herbal Assisted Weight Loss Causes Neurological Ailment In Woman - Intelihealth, 6/11/02 - "The disorder is known to stem from a deficiency of vitamin B1, or thiamine, essential for carbohydrate metabolism"
• An Anti-Atherosclerosis Aid For Adults With Hyperhomocysteinemia? - Doctor's Guide, 6/7/02 - "One year of folic acid supplementation was found to be linked with a significant increase in the subjects' mean plasma folate levels and a significant decline in their homocysteine levels ... Study authors suggest the findings demonstrate long-term folic acid improves arterial endothelial function and has potential implications for prevention of atherosclerosis in people with hyperhomocysteinemia"
• Women Unaware of Folic Acid Benefits - WebMD, 6/4/02 - "only 31% of women between the ages of 18 and 45 take a folic acid supplement every day, despite the fact that the vitamin has been shown to dramatically reduce the risk of serious birth defects ... In fact, only 10% of women realize that the B vitamin folic acid must be taken prior to pregnancy to prevent birth defects of the brain and spine known as neural tube defects ... it takes about a month for the vitamin to provide the maximum benefit"
• Low Vitamin B Status Prevalent In Alzheimer Patients - Doctor's Guide, 6/4/02 - "low vitamin B6 status is prevalent in patients with AD"
• Vitamins Fight Alzheimer's - WebMD, 5/28/02 - "There's new evidence that a substance found in blood can cause the type of brain and blood vessel deterioration that leads to dementia. But those same studies also show that taking certain vitamins can lower levels of this substance -- homocysteine -- and ward off the damage, possibly preventing Alzheimer's disease ... This is exciting information, because homocysteine levels can be reduced by taking the vitamins B6, B12, and folic acid"
• Homocysteine Levels Higher, Serum Vitamin B12 Lower In Vegetarians - Doctor's Guide, 5/27/02 - "Vegetarians have considerably higher levels of total plasma homocysteine, greater prevalence of hyperhomocysteinemia and lower levels of serum vitamin B12 than do non-vegetarians"
• Serum Folate And Estradiol Levels Interact In Alzheimer's Disease - Doctor's Guide, 5/13/02 - "a high ratio of estradiol to total estrogens is linked with AD. At the same time, in women with a high ratio, the severity of dementia is lower in those with high serum folate levels ... If this association is causal, then supplementation with folic acid may have a role in future studies of estrogen replacement therapy (ERT) in Alzheimer's disease (AD)"
• Homocysteine, B Vitamins Associated With Cognitive Function In The Elderly - Doctor's Guide, 5/10/02
• Adjunct Folinic Acid For Depressed Patients With Inadequate SSRI Response - Doctor's Guide, 5/8/02 - "Investigators report that patient folate levels rose. Hamilton Depression Rating Scale-17 (HAM-D-17) scores among 16 patients who completed the study decreased"
• Foods Rich In Folate May Reduce Risk Of Stroke - Intelihealth, 5/3/02
• Folate Fights Stroke and Heart Disease - WebMD, 5/2/02 - "people who consumed at least 300 mcg of folate every day had a 20% lower risk of stroke and a 13% lower risk of cardiovascular disease than those consuming less than 136 mcg of folate per day ... Folate is also thought to offset risk of cardiovascular disease, by reducing levels of homocysteine in the blood. Homocysteine is linked with higher risk of atherosclerosis because it damages arteries, but vitamins B-6 and B-12, as well as folic acid, have been found to prevent that damage from occurring"
• Foods Rich In Folate May Reduce Risk Of Stroke - Intelihealth, 5/2/02
• Nutrition Affects Thinking in Elderly - WebMD, 4/25/02 - "In this study of healthy elderly people, higher concentrations of folic acid and vitamin B-12 were associated with increased memory and thinking ability"
• Supplements Boost Sperm Count - WebMD, 3/20/02 - "Researchers found that the men with fertility problems who took 5 mg of folic acid a day and 66 mg of zinc sulfate a day for 26 weeks had a 74% increase in total normal sperm count"
• Folic Acid May Help Prevent Alzheimer's - WebMD, 3/1/02
• Folic Acid Possibly A Key Factor In Alzheimer's Disease Prevention - Intelihealth, 3/1/02
• In Praise of Folic Acid - Time Magazine, 2/25/02 - "folic acid plays a crucial role in the development of just about every cell in the body ... subjects who had high levels of a particular amino acid called homocysteine in their blood were twice as likely to develop Alzheimer's as those who didn't. The finding is important because one of the easiest ways to lower homocysteine levels is to get plenty of folic acid ... There is no risk of overdose, although high levels of folic acid can mask the signs of pernicious anemia in people who have developed the disorder" - The way I understand it, taking vitamin B12 with the folic acid will avoid that problem. - Ben
• New Alzheimer's Risk Factor Identified - WebMD, 2/13/02 - "High blood levels of a substance called homocysteine have been linked to an increased risk for both heart attack and stroke. Now, new research finds it to be a major risk factor for Alzheimer's disease and other age-related dementias ... It is known that B-vitamins like folic acid, B-6, and B-12 lower homocysteine levels"
• Mix B-12 and Folic Acid for Heart Health - WebMD, 1/18/02 - "Folic acid alone reduces the level of a potentially harmful amino acid in the blood, called "homocysteine." When elevated, homocysteine has been shown to raise the risk of heart disease and stroke. In fact, some heart experts consider homocysteine to be a very important risk factor ... But adding vitamin B-12 to the mix "is likely to be much more effective in lowering homocysteine concentrations,""
• Vitamin B12 Plus Folic Acid Significantly Reduces Homocysteine Levels - Doctor's Guide, 1/17/02 - "This finding suggests that a fortification policy based on folic acid and vitamin B12, rather than folic acid alone, is likely to be much more effective in lowering homocysteine concentrations"
• Folic Acid [deficiency] Linked to Parkinson's Disease - WebMD, 1/17/02 - "The latest research shows that mice on a low-folic-acid diet are much more likely to get Parkinson's disease than mice on a normal diet ... The researchers were able to finger homocysteine as the likely culprit behind the loss of brain cells"
• Pregnancy Vitamins Cut Leukemia in Kids - WebMD, 12/6/01 - "Moms who used both folic acid and iron supplements in pregnancy were 60% less likely to have a child develop leukemia"
• Folic acid and vitamin B12 save lives and money - Life Extension Magazine, 11/01 - "supplementation with folic acid and vitamin B12 would result in a tremendous increase in health and longevity of the American population at a low cost, while saving 24 billion dollars in healthcare costs over the coming decade ... folic acid could lower homocysteine by 25%; the addition of vitamin B12 led to a further 7% drop"
• The Wizard is Oz - Life Extension Magazine, 11/01 - "Best-selling author and nutritional guru to the rich and famous, Oz Garcia is singing the praises of the Life Extension Foundation and its products in his newest book, The Healthy High Tech Body, published in September 2001 ... Supplements at the top of Garcia's list of recommendations ... DHA ... NADH ... Alpah Lipoic Acid ... Acetyl-L-Carnitine ... An expanded list of his recommendations includes lycopene, gamma tocopherol, vinpocetine, SAMe, folic acid, carnosine, glutathione, DMAE, Huperzine A, probiotics, MSM, secretagogues, arginine pyroglutamate, IP-6, bioflavonoid formulas and grape skin/seed extracts"
• Folate Cost-Effective For Prevention Of Coronary Artery Reblockage - Intelihealth, 11/29/01 - "The vitamin therapy included a combination of folic acid (also known as folate or vitamin B9), vitamin B12, and vitamin B6. Patients who received the vitamins had significantly lower levels of homocysteine, and lower rates of restenosis and cardiac complications"
• High Dose Oral Folic Acid Acutely Improves Endothelial Function in Coronary Artery Disease - Doctor's Guide, 11/14/01 - "Although high-dose folic acid (5 mg daily) improves endothelial function in CAD patients, it is controversial as to whether this improvement is due to homocysteine lowering or other direct actions of folic acid"
• Can a Mix of Chromium and Biotin Help Diabetics Control Blood Sugar? - WebMD, 10/15/01
• Memory vitamins - Life Extension Magazine, 9/01 - "Folate and vitamin B12 work together to enhance cognition"
• Folic Acid Doesn't Increase Miscarriage Risk - WebMD, 9/6/01
• Pharmaceutical Drugs Deplete Folic Acid - Nutrition Science News, 9/01
• Many Women Still Don't Take Folic Acid Before Conception - WebMD, 9/5/01
• Folic Acid/Vitamin B12 Show Potential as Heart Disease Treatments - Doctor's Guide, 8/22/01
• Battling Heart Disease with B Vitamins - Life Extension Magazine, 8/01 - "Studies to date have shown that folic acid alone may reduce heart disease risk by as much as 30% to 40%, primarily through its ability to lower homocysteine. In fact, folic acid has been deemed the mainstay of treatment for hyperhomocysteinaemia (elevated homocysteine).(5) However, folic acid works best when teamed up with vitamin B12, which enhances the benefits of folic acid supplementation"
• Could Nicotinamide And Vitamin E Have Synergistic Effect And Reduce Insulin Usage? - Doctor's Guide, 7/11/01 - "The combination of nicotinamide and vitamin E might have a synergistic effect in lowering daily insulin usage among newly diagnosed Type 1 diabetics"
• Alzheimer's Disease May Be Linked to Deficiencies in Vitamin B12 or Folate - Doctor's Guide, 5/8/01
• Folic Acid May Reduce Age-Related Memory Problems - WebMD, 4/27/01 - "High homocysteine levels were independently associated with poor performance on the memory tests, as were low levels of the vitamin folic acid. Folic acid, or folate, has been shown to significantly lower homocysteine levels ... a cocktail of three vitamin supplements -- folic acid, B12, and B6 -- can dramatically lower homocysteine levels, even in those who get the recommended levels of the vitamins in their diets ... Homocysteine levels naturally increase as you age ... Jacobsen, 62, recommends taking 400-800 mcg of folic acid every day and 25-100 mg of vitamin B6. He says it is not clear if B12 supplementation is beneficial in younger people, but it does appear to benefit those over 50. He takes 500 mcg of B12 each day"
• Decreased Memory After Age 60 Linked To High Homocysteine Levels - Doctor's Guide, 4/26/01 - "High circulating levels of homocysteine, especially with increasing age, have been associated with cognitive impairment. In recent studies, Alzheimer disease and dementia after multiple strokes have been linked to extremely high serum homocysteine concentrations ... The folate status of the participants was an important consideration because folate has been shown to significantly modify homocysteine levels"
• Multivitamin With Folic Acid May Reduce Homocysteine More Than With Folic Acid Alone - Doctor's Guide, 4/20/01 - "the supplement containing 800 micrograms of folic acid reduced homocysteine levels by nearly 50 percent while the supplement containing 160 micrograms of folic acid had no significant effect above placebo"
• Pre-conception Advice on Folic Acid Supplementation Recommended - Doctor's Guide, 4/16/01 - "Only about one-quarter of pregnant women currently begin folic acid supplementation early enough to reduce the risk of neural tube defects"
• Synthetic Folate Trumps Food Form - Nutrition Science News, 3/01 -"folic acid may reduce the risk of cardiovascular disease via its ability to reduce homocysteine, an undesirable blood protein. It also prevents birth defects, which a new finding says may be attributed, in part, to folic acid's ability to reduce circulating homocysteine levels ... natural folic acid does not match up to synthetic"
• Sustain the Brain - Nutrition Science News, 2/01
• Vitamins May Help Patients With High Homocysteine Levels - Doctor's Guide, 12/18/00
• Folic Acid and Vitamin B-12 May Help Prevent Heart Disease - WebMD, 12/11/00
• Vitamin B12: Surprising New Findings - Life Extension Magazine, 12/00
• Study confirms benefits of folic acid in pregnancy - CNN, 11/30/00
• Folic Acid Strikes Again, Study Shows Vitamin Protects Against Birth Defects Linked to Common Drugs - WebMD, 11/29/00
• Folic Acid Supplementation Reduces Methotrexate Complications - Doctor's Guide, 10/30/00
• Americans May Be Low in B12 - Nutrition Science News, 10/00
• Women Need a Folic Acid Fix - WebMD, 10/3/00
• Folic Acid Reduces Defects - Intelihealth, 10/3/00
• Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00 - "Another sad case of drug-induced nutrient deficiency involves the depletion of folic acid (also known as folate and folacin) by a myriad of commonly used drugs. These include aspirin and other salicylates, ibuprofen, indomethacin and other non-steroidal anti-inflammatories. Celebrex unfortunately also depletes folic acid. Methotrexate, used in the treatment of rheumatoid arthritis and various cancers such as leukemia and lymphoma, is notorious for depleting folic acid. Likewise, the use of corticosteroids, barbiturates such as phenobarbitol, sulfa drugs such as Bactrim, certain antibiotics, diuretics and oral contraceptives can cause a deficiency of folic acid. The widely used anticonvulsive drug Dilantin (phenytoin) and related drugs also deplete folic acid."
• Folic Acid and the Heart Turning Into Fast Friends - WebMD, 8/31/00
• 3 B's Block Cardiovascular Disease - Nutrition Science News, 7/00
• Fish Oil, Vitamin B-12 May Offer Relief During That Time of the Month - WebMD, 6/20/00
• Nicostatin (Niacin/Lovastatin) Reduces Cholesterol, Triglyceride Levels - Doctor's Guide, 3/16/00
• Niaspan (Niacin Extended-Release) Raises HDL Twice As Much as Gemfibrozil - Doctor's Guide, 3/14/00 (Note: Extended release niacin has been shown to cause liver damage).
• Gemfibrozil-Niacin Combination Greatly Increases Good Cholesterol - Doctor's Guide, 3/10/00
• Niacin for Achy Joints - Nutrition Science News, 11/99
• Folic Acid May Fight Down Syndrome - Intelihealth, 9/29/99
• Study Links Vitamin B Deficiency To Risk Of Stroke In Younger Women - Doctor's Guide, 8/30/99
• Study Finds "New" Cholesterol (Homocysteine) Is Key To Heart Disease - Intelihealth, 5/19/99
• Thiamine Deficiency Linked To Malaria - Doctor's Guide, 2/12/99
• March of Dimes promotes B vitamin to curb birth defects - CNN, 1/28/99
• Folic Acid During Pregnancy Does Not Cause Multiple Births - Doctor's Guide, 1/22/99
• Thiamine's Mood-Mending Qualities - Nutrition Science News, 1/99
• Elevated Homocysteine Levels May Be Possible Risk Factor For Alzheimer Disease - Doctor's Guide, 10/20/98
• Study: Vitamin B-6 may help reduce heart disease - CNN, 7/20/98
• Homocysteine A Possible Risk Factor For Alzheimer's - Doctor's Guide, 4/29/98
• Study: Folic acid boost could save 50,000 lives a year - CNN, 4/9/98
• Report Urges Supplemental Folic Acid For Women of Childbearing Age - Doctor's Guide, 4/8/98
• Natural Sugar-Phosphate Compound Shows Promise In Cancer - Doctor's Guide, 3/30/98 (See IP-6)
• B-Vitamins May Reduce Vessel Damage In Stroke Patients - Doctor's Guide, 2/9/98
• Advice to childbearing-age women: Take more folic acid - CNN, 2/18/97

Abstracts:

• Folate intake and the risk of colorectal cancer in a Korean population - Eur J Clin Nutr. 2009 Jun 24 - "Cases were more frequently found to have a family history of CRC among first-degree relatives, to consume more alcohol, to be more likely current smokers and less likely to participate in vigorous physical activity than the controls. In the overall data for men and women combined, multivariate ORs (95% confidence interval (CI), P for trend) comparing the highest vs the lowest quartile of dietary folate intake were: 0.47 (0.32-0.69, < 0.001) for CRC, 0.42 (0.26-0.69, < 0.001) for colon cancer and 0.48 (0.28-0.81, 0.007) for rectal cancer. An inverse association was also found in women with dietary folate intake: 0.36 (0.20-0.64, < 0.001) for CRC, 0.34 (0.16-0.70, 0.001) for colon cancer and 0.30 (0.12-0.74, 0.026) for rectal cancer, but not in men. In addition, the total folate intake of women was strongly associated with a reduced risk of rectal cancer (OR, 0.38; 95% CI, 0.17-0.88; P for trend=0.04). ... We found a statistically significant relationship between higher dietary folate intake and reduced risk of CRC, colon cancer and rectal cancer in women. A significant association is indicated between higher total folate intake and reduced risk of rectal cancer in women"
• Prospective study of plasma vitamin B6 and risk of colorectal cancer in men - Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1197-202 - "plasma PLP levels were significantly inversely associated with risk of colorectal cancer; compared with men in the lowest quartile, those with PLP in quartiles 2 to 4 had relative risks (95% confidence interval) of 0.92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; P(trend) = 0.01), respectively"
• Prospective Study of Plasma Vitamin B6 and Risk of Colorectal Cancer in Men - Cancer Epidemiol Biomarkers Prev. 2009 Mar 31 - "plasma PLP levels were significantly inversely associated with risk of colorectal cancer; compared with men in the lowest quartile, those with PLP in quartiles 2 to 4 had relative risks (95% confidence interval) of 0.92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; Ptrend = 0.01), respectively. In conclusion, vitamin B6 may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers"
• Selenium, folate, and colon cancer - Nutr Cancer. 2009;61(2):165-78 - "High levels of serum selenium and reported folate jointly were associated with a substantially reduced risk of colon cancer"
• Vitamin B(12) may be more effective than nortriptyline in improving painful diabetic neuropathy - Int J Food Sci Nutr. 2009 Feb 12:1-6 - "In conclusion, vitamin B(12) is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy" - See vitamin B12 products a iHerb.
• High-Dose B Vitamin Supplementation and Progression of Subclinical Atherosclerosis. A Randomized Controlled Trial - Stroke. 2008 Dec 31 - "high-dose B vitamin supplementation (5 mg folic acid+0.4 mg vitamin B12+50 mg vitamin B6) or matching placebo for 3.1 years ... High-dose B vitamin supplementation significantly reduces progression of early-stage subclinical atherosclerosis (carotid artery intima media thickness) in well-nourished healthy B vitamin "replete" individuals at low risk for cardiovascular disease with a fasting tHcy >/=9.1 micromol/L"
• Cobalamin deficiency: Neurological aspects in 27 cases - Rev Neurol (Paris). 2008 Dec 2 - "Combined medullar sclerosis, together with peripheral sensory neuropathies, is the most common neurological manifestation observed in cobalamin deficiency. Biermer's disease is the predominant cause ... cobalamin (B12 vitamin) ... Dysautonomia revealed cobalamin deficiency in three patients with a good and fast response to the cobalamin therapy in all cases ... Outcome was very good in 46% of patients after vitamin replacement, particularly if treatment was started rapidly" - See B12 products at iHerb.
• Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease: A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension - Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We examined the efficacy of a vitamin/nutriceutical formulation (folate, vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl-L-carnitine) in a 12-month, open-label trial with 14 community-dwelling individuals with early-stage Alzheimer's disease. Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox 1 and 2). Family caregivers reported improvement in multiple domains of the Neuropsychiatric Inventory (NPI) and maintenance of performance in the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL). Sustained performance was reported by caregivers for those participants who continued in an 16-month extension. Performance on the NPI was equivalent to published findings at 3 to 6 months for donepezil and exceeded that of galantamine and their historical placebos. Participants demonstrated superior performance for more than 12 months in NPI and ADL versus those receiving naproxen and rofecoxib or their placebo group. This formulation holds promise for treatment of early-stage Alzheimer's disease prior to and/or as a supplement for pharmacological approaches"
• Raised homocysteine and low folate and vitamin B-12 concentrations predict cognitive decline in community-dwelling older Japanese adults - Clin Nutr. 2008 Oct 1 - "Reduced folate and vitamin B-12 concentrations were independently associated with cognitive decline"
• Vitamin B12 status and rate of brain volume loss in community-dwelling elderly - Neurology. 2008 Sep 9;71(11):826-32 - "Linear regression analysis showed that associations with vitamin B(12) and holoTC remained significant after adjustment for age, sex, creatinine, education, initial brain volume, cognitive test scores, systolic blood pressure, ApoE epsilon4 status, tHcy, and folate. Using the upper (for the vitamins) or lower tertile (for the metabolites) as reference in logistic regression analysis and adjusting for the above covariates, vitamin B(12) in the bottom tertile (<308 pmol/L) was associated with increased rate of brain volume loss (odds ratio 6.17 ... Low vitamin B(12) status should be further investigated as a modifiable cause of brain atrophy and of likely subsequent cognitive impairment in the elderly" - See iHerb vitamin B12 products.
• Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer? Results from Model-Based Predictions - Cancer Epidemiol Biomarkers Prev. 2008 Jun 6 - "Changes in colorectal cancer risk in response to folic acid supplementation are likely a complex function of treatment start, duration, and effect on cell proliferation and mutations rates. Predicted colorectal cancer incidence rates under supplementation are mostly higher than rates without folic acid supplementation unless supplementation is initiated early in life (before age 20 years). To the extent to which this model predicts reality, it indicates that the effect on cancer risk when starting folic acid supplementation late in life is small, yet mostly detrimental"
• Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles - Breast Cancer Res Treat. 2008 Apr 22 - "Tamoxifen (TAM) ... TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer ... A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN" - See coenzyme Q10 products at iHerb.
• Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial - Cancer Causes Control. 2008 Mar 6 - "Low dietary folate intake has been associated with colorectal cancer risk and adenoma recurrence. A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk ... In general, no statistically significant associations were found between quartile of folate intake (dietary or total) and adenoma recurrence ... No significant interaction was noted for total folate and MTHFR genotype, though an increased risk of recurrence noted for the MTHFR CT genotype was statistically significant only for those individuals with below median intake of total folate"
• Is folic acid good for everyone? - Am J Clin Nutr. 2008 Mar;87(3):517-33 - "Folate has a dual effect on cancer, protecting against cancer initiation but facilitating progression and growth of preneoplastic cells and subclinical cancers"
• Hepatoprotective effect of vitamin b(12) on dimethylnitrosamine-induced liver injury - Biol Pharm Bull. 2008 Feb;31(2):309-11 - "Vitamin B(12) decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils ... vitamin B(12) could be an effective hepatoprotective agent" - Note:  Aspartate aminotransferase is the AST reading on blood tests and alanine aminotransferase is the ALT.
• Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease - Acta Cardiol. 2007 Dec;62(6):579-85 - "either folic acid 5 mg or NAC 600 mg or placebo daily for eight weeks ... endothelium-dependent dilation (EDD) ... Folic acid and NAC therapies decreased plasma homocysteine (from 21.7 +/- 8.7 micromol/l to 12.5 +/- 2.5 micromol/l, P < 0.001; from 20.9 +/- 7.6 micromol/l to 15.6 +/- 4.3 micromol/l, P = 0.03, respectively), and increased EDD (6.7 +/- 6.1% P = 0.002, 4.4 +/- 2.6% P < 0.001, respectively) compared with placebo. There was no significant difference in improving EDD between the folic acid and the NAC group"
• Dietary vitamin b6 intake and the risk of colorectal cancer - Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82 - "Moderately strong inverse and dose-dependent associations in the whole sample were found between CRC risk and the intake of dietary and total vitamin B6 in all three models [model III: odds ratio (OR), 0.77; 95% confidence interval (95% CI), 0.61-0.98; P for trend = 0.03; OR, 0.86; 95% CI, 0.69-1.07; P for trend = 0.12]. In addition, meta-analyses of published studies showed inverse associations between vitamin B6 and CRC (combined relative risk, 0.81; 95% CI, 0.68-0.96; test for overall effect P = 0.01; combined odds ratio, 0.67; 95% CI, 0.60-0.75; test for overall effect P < 0.00001)"
• Folic acid supplementation in early second trimester and the risk of preeclampsia - Am J Obstet Gynecol. 2008 Jan;198(1):45.e1-7 - "Supplementation of multivitamins containing folic acid was associated with increased serum folate (on average 10.51 micromol/L), decreased plasma homocysteine (on average 0.39 micromol/L), and reduced risk of preeclampsia (adjusted odds ratio, 0.37; 95% confidence interval, 0.18-0.75)" - See iHerb folic acid products.
• Vitamin B6 treatment for tardive dyskinesia: a randomized, double-blind, placebo-controlled, crossover study - J Clin Psychiatry. 2007 Nov;68(11):1648-54 - "The mean decrease in ESRS clinical global impression scores from baseline to endpoint was 2.4 points in patients treated with vitamin B(6) and 0.2 points in patients treated with placebo (p < .0001). The mean decrease in the parkinsonism subscale score was 18.5 points and 1.4 points, respectively (p < .00001), and the mean decrease in the dyskinesia subscale score was 5.2 points and -0.8 points, respectively ... Vitamin B(6) appears to be effective in reducing symptoms of TD. The specific mechanisms by which vitamin B(6) attenuates symptoms of TD are not clear"
• Association of folate intake with the occurrence of depressive episodes in middle-aged French men and women - Br J Nutr. 2007 Dec 6;:1-5 - "the risk of experiencing recurrent depressive episodes (two or more) during the follow-up was strongly reduced in men with high folate intake (OR 0.25 (95 % CI 0.06, 0.98) for the highest tertile v. the lowest" - See iHerb folic acid products.
• Low vitamin B-12 status and risk of cognitive decline in older adults - Am J Clin Nutr. 2007 Nov;86(5):1384-91 - "concentrations of holoTC (a marker of reduced vitamin B-12 status), tHcy, and MMA predicted cognitive decline, but folate did not. A doubling in holoTC concentrations (from 50 to 100 pmol/L) was associated with a 30% slower rate of cognitive decline (-0.137 to -0.083), whereas a doubling in tHcy (from 10 to 20 mumol/L) or MMA (from 0.25 to 0.50 mumol/L) was associated with >50% more rapid cognitive decline (-0.090 to -0.169) and (-0.104 to -0.169), respectively" - See iHerb vitamin B12 products.
• Low vitamin B-12 status and risk of cognitive decline in older adults - Am J Clin Nutr. 2007 Nov;86(5):1384-91 - "Low vitamin B-12 status was associated with more rapid cognitive decline"
• Homocysteine, vitamins, and vascular disease prevention - Am J Clin Nutr. 2007 Nov;86(5):1563S-8S - "Dietary deficiency of vitamin B-6 and folic acid and absorptive deficiency of vitamin B-12, which result from traditional food processing or abnormal absorption of B vitamins, are important factors in causing elevations in blood homocysteine. Numerous clinical and epidemiologic studies have established elevated blood homocysteine as a potent independent risk factor for vascular disease in the general population. Dietary improvement, providing abundant vitamin B-6, folic acid, and cobalamin, may prevent vascular disease by lowering blood homocysteine. The dramatic decline in cardiovascular mortality in the United States since 1950 may possibly be attributable in part to voluntary fortification of the food supply with vitamin B-6 and folic acid. Fortification of the US food supply with folic acid in 1998, as mandated by the US Food and Drug Administration, was associated with a further decline in mortality from vascular disease, presumably because of increased blood folate and decreased blood homocysteine in the population"
• Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels - Atherosclerosis. 2007 Oct 16 - "Retinal vein occlusion (RVO) is one of the most common retinal vascular disorders ... Blood levels of vitamin B6, folate and Hcy, but not of vitamin B12, were found to be significantly different in patients as compared to healthy subjects. At the univariate analysis, the lowest tertile of vitamin B6 [odds ratio (OR) 4.03; 95% confidence interval (CI) 2.58-6.31; P<0.0001)] and folate (OR 6.13; 95% CI 3.85-9.76, P<0.0001), and the highest tertile of Hcy (OR 8.08; 95% CI 5.05-12.92, P<0.0001) were found to be significantly associated with RVO. Moreover, at multivariate analysis, after adjustment for traditional cardiovascular risk factors, Hcy, and circulating levels of vitamins, respectively, the lowest tertile of vitamin B6 (OR 3.29; 95% CI 1.89-5.70, P<0.0001) and folate (OR 5.41; 95% CI 3.08-9.51, P<0.0001) and the highest tertile of Hcy (OR 2.58; 95% CI 1.12-5.94, P<0.0001) maintained their significant association with RVO"
• Augmenting antidepressants with folate: a clinical perspective - J Clin Psychiatry. 2007;68 Suppl 10:4-7 - "Folate in particular has been found to further reduce symptoms in patients with depression when used in conjunction with an antidepressant, and because folate is a water-soluble B vitamin, its safety and tolerability are well established. This strategy would typically be used in patients with low plasma or red blood cell folate levels. Folate augmentation may be used (1) to enhance the efficacy of antidepressants in nonresponders, (2) to enable those who partially respond to antidepressant monotherapy to achieve remission, and (3) to alleviate residual symptoms during antidepressant treatment" - See iHerb folic acid products.
• The role of folate in depression and dementia - J Clin Psychiatry. 2007;68 Suppl 10:28-33 - "folate deficiencies may be caused by improper absorption and utilization, often due to genetic polymorphisms. Individuals, therefore, can have insufficient levels or lack needed forms of folate, despite adequate intake. Supplementation with the active form of folate, methyltetrahydrofolate, which is more readily absorbed, may be effective in the prevention and treatment of both depression and dementia" - iHerb folic acid products.
• B Vitamin Plasma Levels and the Risk of Ischemic Stroke and Transient Ischemic Attack in a German Cohort - Stroke. 2007 Sep 20 - "Our data suggest that low vitamin B12 plasma levels, particularly in combination with low folate levels, increase the risk of cerebral ischemia. This effect may be mediated at least partly through elevations of homocysteine levels"
• Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn's disease - Inflamm Bowel Dis. 2007 Sep 20 - "Vitamin B(12) abnormalities are common in patients with CD and patients with a prior ileal or ileocolonic resection are at particular risk" - See iHerb Vitamin B12 products.
• Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders - Fortschr Neurol Psychiatr. 2007 Sep;75(9):e1-e18 - "Elevated concentration of total homocysteine (Hcy) in plasma (> 12 micromol/l) is a risk factor for several diseases of the central nervous system. Epidemiological studies have shown a dose-dependent relationship between concentrations of Hcy and the risk for neurodegenerative diseases. Hcy is a marker for B-vitamin deficiency (folate, B (12), B (6)). Hyperhomocysteinemia (HHcy) causes hypomethylation which is an important mechanism that links Hcy to dementia ... Current evidence suggests that Hcy-lowering treatment has a positive effect for the secondary and primary prevention of stroke. HHcy is very common in patients with Parkinson disease particularly those who receive L-dopa treatment. Furthermore, a positive association has been reported between HHcy and multiple sclerosis. Moreover, HHcy and vitamin B deficiency are reported to have a causal role in depression, and epilepsy. In addition several anti-epileptic drugs cause secondary HHcy. Therefore, sufficient intakes of the vitamins are recommended for patients who have already developed neuropsychiatric diseases. Vitamin B deficiency should be suspected in children with development disorders, failure to thrive and unexplained neurological manifestations. Elderly people are also an important at-risk group where vitamin B deficiency and HHcy have been linked to neurodegenerative diseases. Treatment with folate, B (12), and B (6) can improve cerebral function. Preventive vitamin B supplementation and sufficient intake seem very important for secondary and primary prevention of neuropsychiatric disorders, especially in subjects with a low intake or status of the vitamins"
• Plasma folate concentration and cognitive performance: Rotterdam Scan Study - Am J Clin Nutr. 2007 Sep;86(3):728-34 - "After multivariate adjustment, the mean change in test score per 1-SD increase in plasma folate was 0.05 (95% CI: 0.01, 0.09) for global cognitive function, 0.08 (95% CI: 0.04, 0.13) for psychomotor speed, and 0.02 (95% CI: -0.04, 0.07) for memory function ... The odds ratio relating a 1-SD increase in plasma folate to the presence compared with the absence of severe white matter lesions was 0.79 (95% CI: 0.66, 0.94), whereas no relation was seen between folate status and hippocampal or amygdalar volume" - See iHerb folic acid products.
• Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: The Rotterdam Study - one. 2007 Aug 17 - "As compared to the three lowest quartiles, individuals in the highest quartile of age- and energy-adjusted dietary pyridoxine intake had a decreased risk of non-vertebral fractures (HR=0.77, 95% CI=0.65-0.92, p=0.005) and of fragility fractures (HR=0.55"
• Folate: in vitro and in vivo effects on VLDL and LDL oxidation - Int J Vitam Nutr Res. 2007 Jan;77(1):66-72 - "folic acid supplementation reduced tHcy and protected both VLDL and LDL against oxidation. These findings provide further support for the use of folic acid supplements to aid in the prevention of atherosclerosis"
• High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort - Am J Clin Nutr. 2007 Aug;86(2):434-43 - "Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59" - See iHerb folic acid products.
• Efficacy of folic acid supplementation in stroke prevention: a meta-analysis - Lancet. 2007 Jun 2;369(9576):1876-82 - "Folic acid supplementation significantly reduced the risk of stroke by 18%"
• Correlations between folate, B12, homocysteine levels, and radiological markers of neuropathology in elderly post-stroke patients - J Am Coll Nutr. 2007 Jun;26(3):272-8 - "folate deficiency and hyperhomocysteinemia are prevalent in elderly post-stroke patients. These two conditions are strongly and independently associated with the development of brain atrophy"
• Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort - Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1279-82 - "When comparing persons in the lowest quartile RBC folate to persons in all other quartiles, the analysis found that higher RBC folate levels were associated with reduced risk of hepatocarcinogenesis (odds ratio, 0.33" - See iHerb folic acid products.
• Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients - Curr Med Res Opin. 2007 Jun 29 - "Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis"
• Low Intake of Vitamin B-6 Is Associated with Increased Risk of Colorectal Cancer in Japanese Men - J Nutr. 2007 Jul;137(7):1808-1814 - "We observed a significant inverse association between vitamin B-6 intake and colorectal cancer in men. Compared with the lowest quartile, the multivariate hazard ratio (95% [CI]) in the highest quartile of intake was 0.69"
• Effect of folic Acid on endothelial function following acute myocardial infarction - Am J Cardiol. 2007 Feb 15;99(4):476-81 - "6-week treatment with high-dose folic acid improves endothelial function in post-AMI patients, independent from homocysteine status. Folic acid can be recommended to improve postinfarction endothelial dysfunction in patients with normo- and hyperhomocysteinemia"
• Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial - Lancet. 2007 Jan 20;369(9557):208-16 - "Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age"
• Vitamin B6 supplementation increases immune responses in critically ill patients - Eur J Clin Nutr. 2006 Oct;60(10):1207-13 - "T-lymphocyte and T-helper cell numbers and the percentage of T-suppressor cell significantly increased on day 14 in the B6 -50 group. Total lymphocyte count, T-helper and T-suppressor cell numbers, the percentage of T-lymphocyte cells and T-suppressors significantly increased in the B6 -100 group at the 14th day"
• B-vitamins reduce plasma levels of beta amyloid - Neurobiol Aging. 2006 Nov 17 - "Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (Abeta40). We randomized 299 older men to treatment with 2mg of folate, plus 25mg of B6 and 400mug of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Abeta40 was 7.0pg/ml (8.4) in the vitamin group (4.9%), and 26.8pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Abeta40 and have a role in the prevention of AD"
• High- but not low-dose folic acid improves endothelial function in coronary artery disease - Eur J Clin Invest. 2006 Dec;36(12):850-9 - "Both 400 microg day(-1) and 5 mg day(-1) FA significantly increased plasma folate and decreased plasma Hcy. The FMD improved significantly after 6 weeks' treatment of 5 mg day(-1) FA but did not correlate with the reduction in Hcy. There was no change in FMD in either the 400 microg FA or placebo group"
• Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering - Vasc Med. 2006 May;11(2):101-9 - "2 weeks of folic acid supplementation can improve endothelial dysfunction in type 2 diabetics independent of homocysteine-lowering" - See iHerb or Vitacost folic acid products.
• Folate and vitamin b6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus - Pediatrics. 2006 Jul;118(1):242-53 - "High-dose folate and vitamin B(6) normalized endothelial dysfunction in children with type 1 diabetes. This effect was maintained over 8 weeks, with no additional benefit from combination treatment"
• Loss of vision as a presenting sign of cobalamin deficiency: An eye-opener - Eur J Intern Med. 2006 Jul;17(4):292-4 - "We describe a patient who presented with loss of vision that turned out to be caused by cobalamin deficiency. Both her vision and her visual field improved upon supplementation of cobalamin. It is, therefore, important to consider cobalamin deficiency as a treatable cause of loss of vision" - Note:  Cobalamin is vitamin B12.
• Older Adults May Need B12 Dose More Than 200 Times the RDA to Normalize Mild Vitamin Deficiency - Medscape, 5/26/06 - "As both methylmalonyl-coenzyme A (MMA) and homocysteine are metabolized by vitamin B12, elevated levels of these compounds in the plasma can reflect vitamin deficiency ... One analysis yielded 500 μg of vitamin B12 as the minimum dose necessary to produce the greatest effect on MMA levels. There was little additional benefit in using daily doses of vitamin B12 of more than 500 μg"
• Effect of nicotinamide on newly diagnosed type 1 diabetic children - Acta Pharmacol Sin. 2006 Jun;27(6):724-7 - "even low doses of oral NA given to children with newly diagnosed type 1 diabetes may reduce insulin requirements and prolong the honeymoon period"
• Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials - Fam Pract. 2006 Apr 3 - "The evidence derived from these limited studies suggests that 2000 microg doses of oral vitamin B12 daily and 1000 microg doses initially daily and thereafter weekly and then monthly may be as effective as intramuscular administration in obtaining short-term haematological and neurological responses in vitamin B12-deficient patients"
• Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype - Am J Clin Nutr. 2005 Jul;82(1):26-31 - "5 mg folic acid/d ... Folic acid reduced brachial pulse pressure by 4.7 ... Folic acid is a safe and effective supplement that targets large artery stiffness and may prevent isolated systolic hypertension" - See iHerb or Vitacost folic acid products.
• Reducing toxicity of methotrexate with folic acid - Z Rheumatol. 2005 Jun;64(5):353-8 - "Folate supplementation should, therefore, be routinely prescribed to every patient taking low-dose methotrexate" - See iHerb or Vitacost folic acid products.
• Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products - CMAJ. 2005 Jun 7;172(12):1569-73 - "Vitamin B12 deficiency is surprisingly common among patients with vascular disease, and, in the setting of folic acid fortification, low serum vitamin B12 levels are a major determinant of elevated homocysteine levels and increased carotid plaque area"
• Oral Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency  - Arch Intern Med. 2005;165:1167-1172 - "The lowest dose of oral cyanocobalamin required to normalize mild vitamin B12 deficiency is more than 200 times greater than the recommended dietary allowance, which is approximately 3 µg daily"
• Folate and brain function in the elderly - Curr Opin Clin Nutr Metab Care. 2004 Nov;7(6):659-664 - "folate status does predict response to antidepressant treatment in older individuals. Cognitive decline and some forms of dementia, including Alzheimer's disease, are associated with lower folate levels. Supplementation with folic acid can provide cognitive benefits in some circumstances"
• Vitamin B6 level is associated with symptoms of depression - Psychother Psychosom. 2004 Nov-Dec;73(6):340-3 - "A low plasma level of PLP was significantly associated with the depression score"
• Folate treatment and insulin resistance -  Eur J Endocrinol. 2004 Oct;151(4):483-9 - "Folate and B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with the metabolic syndrome, suggesting that folic acid had several beneficial effects on cardiovascular disease risk factors"
• Folate for depressive disorders - J Psychopharmacol. 2004 Jun;18(2):251-6 - "adding folate reduced Hamilton Depression Rating Scale (HDRS) scores on average by a further 2.65 points ... The remaining study found no statistically significant difference when folate alone was compared with trazodone"  - See iHerb or Vitacost folic acid products.
• Vitamin B(12) (cobalamin) deficiency in elderly patients - CMAJ. 2004 Aug 3;171(3):251-259 - "VITAMIN B(12) OR COBALAMIN DEFICIENCY occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective"
• Role of vitamins in the risk, prevention, and treatment of breast cancer - Curr Opin Obstet Gynecol. 2004 Feb;16(1):19-25 - "High intake of folate or adequate circulating levels of folate may reduce the risk of breast cancer. Adequate folate levels may be particularly important for women who are at higher risk of breast cancer because of high alcohol consumption. The inverse association between vitamin D and risk of breast cancer needs to be evaluated in more studies" - See iHerb or Vitacost folic acid products.
• High vitamin B12 level and good treatment outcome may be associated in major depressive disorder - BMC Psychiatry. 2003 Nov 27 - "Higher vitamin B12 levels significantly associated with a better outcome" - See iHerb or Vitacost Vitamin B12 products.
• Dietary Folate and Depressive Symptoms Are Associated in Middle-Aged Finnish Men -J Nutr. 2003 Oct;133(10):3233-3236 - "The participants were grouped into thirds according to their dietary folate intake. Those in the lowest third of energy-adjusted folate intake had a higher risk of being depressed [odds ratio (OR) 1.67, 95% CI = 1.19-2.35, P = 0.003] than those in the highest folate intake third ... There were no associations between the intake of cobalamin, pyridoxine or riboflavin, and depression. These results indicate that nutrition may have a role in the prevention of depression" - See iHerb or Vitacost folic acid products.
• Early response to oral cobalamin therapy in older patients with vitamin B12 deficiency - Ann Med Interne (Paris) 2003 Mar;154(2):91-5 - "Our findings suggest that cyanocobalamin given orally during one week may be an effective treatment for cobalamin deficiency related to food-cobalamin malabsorption and nutritional deficiency and may avoid painful intra-muscular injections in older patients"
• Oral vitamin B12 can change our practice - Postgrad Med J 2003 Apr;79(930):218-9 - "Forty patients previously maintained on vitamin B12 injections were given 1000 micro g of oral cyanocobalamin daily for up to 18 months. All the patients maintained satisfactory serum B12 levels"
• Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain Fortification - Stroke 2003 May 8 - "Low B6 but not tHcy was strongly associated with cerebrovascular disease in this postfortification, folate-replete sample"
• Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study - Am. Journ. of Clin. Nutri., 5/03 - "In older adults, daily supplementation with folic acid effectively lowers plasma homocysteine concentrations, and a daily dose of ~ 400 µg is the minimum dose required for adequate homocysteine reduction" - See iHerb or Vitacost folic acid products.
• Interrelationship of homocysteine-cobalamin-folate indices in human subjects of various ages: can hyper-homocyteinemia be relieved with B-12 supplementation? - Mo Med 2003 Mar-Apr;100(2):155-8 - "Thirty-nine of the subjects who had hyperhomocysteinemia were daily given 100 mcg B-12 for three months ... B-12 supplementation is effective in alleviating hyperhomocysteinemia"
• Depression and Folate Status in the US Population - Psychotherapy and Psychosomatics 2003;72:80-87 - "Low folate status was found to be most characteristic of recently recovered subjects, and a large proportion of such subjects were folate deficient. Conclusions: Low folate status was detectable in depressed members of the general US population. Folate supplementation may be indicated during the year following a depressive episode"
• Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people - Neurosci Lett 2003 May 8;341(3):173-6 - "We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume ... These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration"
• Clinical manifestations of the mouth revealing Vitamin B12 deficiency before the onset of anemia - Ann Dermatol Venereol 2003 Feb;130(2):191-4 - "Vitamin B12 deficiency revealed by stomatodynia, glossitis and erosions in the mouth ... the majority of cases of Vitamin B12 deficiency reported in the literature were only discovered several months or years after their onset, or were treated for other causes. Vitamin B12 deficiency leads to severe neuropathies. The neurological damage is reversible when replacement therapy is initiated early. Since the oral signs appear before the modification in the systemic markers of deficiency, it is crucial that these signs be recognized and diagnosed before the occurrence of severe after effects" - See iHerb or Vitacost Vitamin B12 products.
• Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease - Am J Clin Nutr. 1999 Nov;70(5):881-7
• Prolonged treatment with slow release nicotinic acid in patients with type II hyperlipidemia - Pol Arch Med Wewn. 1997 Nov;98(11):391-9

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