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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
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Anti-aging Research > B Vitamins.
B Vitamins
Specific Recommendations:
CME/CEM:
General Information:
-
Vitamin B-Complex
- Vitacost Health Library
-
Vitamin B1 (Thiamine)
- Vitacost Health Library
-
Vitamin B2 (Riboflavin)
- Vitacost Health Library
-
Vitamin B3 (Niacin/Niacinamide)
- Vitamin Health Library
-
Vitamin B5 (Pantothenic Acid)
- Vitacost Health Library
-
Vitamin B6 (Pyridoxine)
- Vitacost Health Library
-
Vitamin B9 (Folic Acid)
- Vitacost Health Library - "folic acid
supplementation can interfere with the laboratory diagnosis of vitamin B12
deficiency, possibly allowing the deficiency to progress undetected to the
point of irreversible nerve damage"
-
Vitamin B12
- Vitacost Health Library
-
Biotin
- Vitacost Health Library
-
Inositol
- Vitacost Health Library
-
PABA
- Vitacost Health Library
-
Vitamin B12 Deficiency
- Vitacost Health Library
-
Who should take a B-complex multivitamin?
- drugstore.com
-
B-Vitamins and
Heart Disease - thenutritionreporter.com
Other News:
-
Brief,
High Doses Of Folate -- B Vitamin -- Blunt Damage From Heart Attack -
Science Daily, 3/27/08 - "Long known for its role in
preventing anemia in expectant mothers and spinal birth defects in newborns, the
B vitamin folate, found in leafy green vegetables, beans and nuts has now been
shown to blunt the damaging effects of heart attack when given in short-term,
high doses to test animals ... a high dose of folic acid for humans comparable
to that given the rats would require an average-size adult to swallow more than
200 one-milligram pills per day, "an impractical and unrealistic regimen, even
if the body excretes the excess."" - I debated whether to publish
this. It is a ridiculous amount.
-
Vitamin
B6 and Homocysteine Changes Seen in Women With Rheumatoid Arthritis -
Medscape, 3/25/08 - "those with rheumatoid arthritis are
deficient in vitamin B6 and have elevated levels of homocysteine ... The vitamin
B6 deficit appears to be the result of altered metabolism, not reduced dietary
intake ... dietary intake of B vitamins is not decreased in rheumatoid arthritis
patients, yet they still show a deficit of vitamin B6. Consistent with this
finding, rheumatoid arthritis was also associated with increased levels of
homocysteine. None of the subjects in the study were using B vitamin supplements
... Individuals with rheumatoid arthritis may need to get more B vitamins
through diet, supplements, or fortified foods"
-
Dads-to-Be May Need Folate, Too - WebMD, 3/20/08 -
"Sperm with chromosomal abnormalities called aneuploidy were rare for all of the
men, but they were 18% to 30% rarer in men who reported high folate or folic
acid intake" - See
folic acid products at iHerb
.
-
Folate
Deficiency Associated With Tripling Of Dementia Risk, Study Shows - Science
Daily, 2/5/08 - "Folate deficiency is associated with a
tripling in the risk of developing dementia among elderly people" - See
iHerb
folic acid products.
-
Testosterone Reduces
Visceral Fat Gain in Nonobese Older Men - Medscape, 2/1/08
-
Large
Study Links Folic Acid Supplementation With Reduced Risk Of Preeclampsia During
Pregnancy - Science Daily, 1/23/08 - "preeclampsia
occurred in 2.2 per cent of women who took multivitamins containing folic acid
compared to 5.1 per cent of women who did not"
-
Vitamin B6 may slash colorectal cancer risk - Nutra USA, 1/17/08 -
"High vitamin B6 intakes were reported to reduce the
risk of colorectal cancer by 19 per cent. The protective effect was found to be
higher among 55-year-old individuals (1,001 cases compared to 1,010 controls)" -
[Abstract]
-
CDC to Young Women: Take Folic Acid - WebMD, 1/10/08 -
"All women, especially younger women ages 18-24 years,
need to consume 400 micrograms of folic acid daily through supplements,
fortified foods, or both in addition to a folate-rich diet to prevent serious
birth defects"
-
Folic
Acid and Stroke--Finally Some Good News - Medscape, 1/3/08 -
"the results of this trial were notable for a 25%
relative reduction in the risk for stroke among participants receiving folate
and B vitamins vs placebo"
-
Vitamin
B-12 Function May Be Diminished By Excessive Folate - Science Daily,
12/21/07 - "homocysteine and methylmalonic acid are at
much higher levels in individuals who have a combination of vitamin B12
deficiency and high blood folate levels than in individuals who are also vitamin
B12 deficient but have normal folate levels"
-
Excess folate worsens B12 deficiency effects: study - Nutra USA, 12/19/07 -
"Finding that the combination of high blood folate
levels and low vitamin B12 status is associated with even higher levels of these
compounds is a strong indication that the high folate is interfering with the
action of these B12-containing enzymes, thus resulting in the exacerbation or
worsening of the vitamin B12 deficiency"
-
Folate may reduce depression symptoms for men, says study - Nutra USA,
12/7/07 - "male subjects with the highest average intake
(235 micrograms per 100 kcal) were 50 per cent less likely to have depressive
symptoms than men with the lowest average intake (119 micrograms per 100 kcal)"
- [Abstract]
- See
iHerb
folic acid products.
-
Increased B12 levels could ward off dementia - Nutra USA, 11/16/07 -
"The longitudinal cohort study followed 1648
participants for 10 years, and found a doubling in holotranscobalamin (holoTC)
concentrations was associated with a 30 per cent slower rate of cognitive
decline ... increased levels of the amino acid homocysteine doubled the risk of
dementia or cognitive impairment" - [Abstract]
- See
iHerb
vitamin B12 products.
-
Folic Acid in Preconceptual Period May Have a Preventive Effect on Congenital
Heart Disease - Doctor's Guide, 11/6/07 - "The
recent increase in folic acid intake has resulted in a decrease in the
prevalence of infants born with severe congenital heart disease (CHD),
supporting the idea that folic acid taken preconceptually may prevent CHD"
-
Riboflavin boosts folate's colorectal cancer protection - study - Nutra USA,
10/29/07
-
Mesalamine, Folic Acid Each Cut Colorectal Cancer in Patients With Inflammatory
Bowel Disease - oncologystat.com, 10/24/07 -
"Patients who took at least 1 mg of folic acid daily also had about a 90% cut in
their CRC incidence during follow-up, compared with the controls" - See
iHerb
folic acid products.
-
Folic
Acid Lowers Blood Arsenic Levels, Study Shows - Science Daily, 10/8/07 -
"treatment with 400 micrograms a day of folic acid, the
U.S. recommended dietary allowance, reduced total blood arsenic levels in the
study population by 14 percent"
-
Pantethine: A Better
Cholesterol Treatment? - Dr. Weil, 10/8/07
-
Increased folate may slash breast cancer risk - Nutra USA, 8/9/07 -
"women in the highest average intake group (456
micrograms of folate per day) had a 44 per cent lower risk of invasive breast
cancer than women in the lowest average intake group (160 micrograms of folate
per day)" [Abstract]
-
Vitamin
B1 Deficiency Key To Vascular Problems For Diabetic Patients, Study Suggests
- Science Daily, 8/7/07 - "thiamine concentration in
blood plasma was decreased 76% in type 1 diabetic patients and 75% in type 2
diabetic patients ... the decreased availability of thiamine in vascular cells
in diabetes was linked to a marker of microvascular and macrovascular
complications"
-
Too Much (Good-for-You) Folate Might Be Really Bad - US News and World
Report, 8/5/07 - "Cells use folate to keep their genetic
software—their DNA—in good repair and to make copies of DNA when they divide.
DNA is less likely to develop the sorts of defects that lead to cancer when it's
well maintained, so folate may lower cancer risk in people who are healthy. But
once a defect is present, experts theorize, replicating cancer cells hungrily
gobble up folate to make new copies of their malevolent DNA"
-
Selective Vitamin Supplementation May Improve Cognitive Functions - Clinical
Psychiatry News, 6/07 - "Supplementation with vitamins
B6 and B12 and folate in younger to middle-aged adults improves motor speed and
sequencing ability on neuropsychological tests ... participants who took the
supplements performed the task significantly faster than they had a month
before, which indicated increased motor speed. The placebo group patients had no
improvement on this test ... Among people who entered the trial with vitamin B12
levels on the low end of the normal range, those who received supplementation
significantly improved their performance on the Trail Making Test Parts A and B.
Part B includes some assessment of executive function"
-
Folate may reduce liver damage study - Nutra USA, 7/6/07 -
"higher red blood cell folate levels were associated
with a 67 per cent reduced risk of liver cancer" - [Abstract]
- See
iHerb
folic acid products.
-
Folic acid 'reduces
stroke risks' - BBC News, 5/31/07 - "They found the vitamin reduced the relative risk of stroke by an average of 18%
... An even greater risk reduction - 30% - was seen when the treatment lasted
more than 36 months"
-
Folic Acid May Lower Stroke Risk - WebMD, 5/31/07
-
High Folate Intake May Lower AD Risk - Clinical Psychiatry News, 2/07 -
"The risk of AD decreased with
increasing intake of folate but not of vitamins B6 or B12"
-
Folate
And B12 May Influence Cognition In Seniors - Science Daily, 2/12/07 -
"People with normal vitamin B12 status
performed better if their serum folate was high ... But for people with low
vitamin B12 status, high serum folate was associated with poor performance on
the cognitive test ... For seniors, low vitamin B12 status and high serum folate
was the worst combination"
-
Folic acid effects two-faced depending on B12 levels, says study - Nutra
USA, 1/31/07 - "In this study of older
Americans in the age of folic acid fortification, we found direct associations
between high serum folate and both anaemia and cognitive impairment in subjects
with low vitamin B12 status ... Among subjects with normal vitamin B12 status,
on the other hand, high serum folate was associated with protection from
cognitive impairment"
-
Folic Acid Improves
Cognitive Performance in Older Adults - Medscape, 1/19/07 -
"Patients were randomized to either
placebo or 800 µg daily of folic acid for 3 years ... 3 years of treatment with
folic acid conferred on individuals resulted in the performance of someone 4.7
years younger for memory, 1.7 years younger for sensorimotor speed, 2.1 years
younger for information processing speed, and 1.5 years younger for global
cognitive function"
-
Higher
Folate Levels Linked To Reduced Risk For Alzheimer's Disease - Science
Daily, 1/9/07 - "Folate, vitamin B12 and
vitamin B6, are important in the body's processing of homocysteine--therefore,
deficiencies in these nutrients increase homocysteine levels and may contribute
to cardiovascular disease, stroke and dementia ... When the individuals were
divided into four groups based on the total level of folate they took in through
food and supplements and the analysis was adjusted for patient characteristics,
comorbid diseases and B12 and B6 intake, the risk of Alzheimer's disease was
lower in the groups with higher intake" - See
iHerb
or
Vitacost
folic acid products.
-
Folic Acid May Slow
Hearing Loss - WebMD, 1/2/07 - "Half
the study participants got strong folic acid supplements -- 800 micrograms per
day, about twice what one would get in a multivitamin pill ... After three
years, those who got folic acid pills had less low-frequency hearing loss than
did placebo recipients"
-
Poor
Athletic Performance Linked To Vitamin Deficiency - Science Daily, 12/27/06
- "Current national B-vitamin
recommendations for active individuals may be inadequate, and athletes who
follow the recommended daily allowances set by the U.S. government may be
receiving lower amounts of nutrients than there bodies need"
-
Research Affirms the Benefits of Combination of Chromium Picolinate and Biotin
for Improving Blood Sugar in People with Type 2 Diabetes - Doctor's Guide,
12/20/06 - "The 30-day study examined 36
overweight or obese poorly controlled patients with type 2 diabetes taking
Diachrome who were already receiving oral anti-diabetic drug(s). The results
also showed a significantly greater reduction in the total area under the curve
for glucose (AUCg) during the oral glucose tolerance test (OGTT) for the
treatment group (mean change -9.7%) compared with the placebo group (mean change
+5.1%)"
-
Use
Folic Acid To Cut Heart Disease, Say Experts - Science Daily, 11/28/06 -
"The scientific evidence is strong
enough to justify using folic acid as a cheap and simple way of reducing heart
disease and strokes"
-
Folic Acid Modestly
Protects Against Cardiovascular Events - Medscape, 11/27/06 -
"the combined evidence from cohort,
genetic, and randomized controlled studies is indeed strong enough to support a
modest protective effect of this nutrient"
-
Low
Folate Diets Found To Increase Risk Of Colorectal Cancer - Science Daily,
11/14/06 - "None of the mice fed a
control diet developed tumours whereas 1 in 4 mice on the folate-deficient diet
developed at least one tumour"
-
Encouraging Results For Folic Acid As A Cancer Prevention Drug - Science
Daily, 6/12/06 - "31 of 43 patients with
the precancerous laryngeal lesion called leucoplakia demonstrated 50 percent or
greater reduction in the lesion size after six months of taking folate
supplements. In 12 of 31 responders, there was no evidence of the original
lesion ... Folate deficiency is the most common vitamin deficiency in the United
States"
- Vitamin B6
May Help Prevent Colorectal Cancer - Medscape, 6/10/06 -
"There was an inverse association
between vitamin B6 intake and colorectal cancer, with the relative risk (RR)
for the highest quintile vs the lowest quintile being 0.66 ... Vitamin B6
may have a role in colorectal cancer prevention through reduction of
oxidative stress and synthesis of a form of folate required for DNA repair,
synthesis, and methylation"
- Does your heart need more
vitamin B? - MSNBC, 6/2/06
- Folic Acid May
Cut Stroke Deaths - WebMD, 3/13/06 - "In the U.S. and Canada, stroke deaths declined at a faster rate after
mandatory folic acid (also known as folate) fortification"
-
Treating Hair
Loss Naturally - WebMD - "Daly
says he routinely recommends up to 3 mg of biotin daily for his hair loss
patients, while Lessman developed a healthy hair, skin, and nails product
containing 2 mg of biotin per daily dosage, which he believes is the minimum
for healthy hair"
-
Thiamin Deficiency Common in Hospitalized Heart Failure Patients -
Doctor's Guide, 1/13/06 - "Among
patients hospitalized with heart failure, about one in three has deficient
levels of thiamin ... a relatively small dose of thiamin from a
multi-vitamin was protective against developing thiamin deficiency"
- Folic Acid
to Boost Memory? - Dr. Weil, 12/13/05 -
"those who took the folic acid had
memory scores equal to people five and a half years younger"
-
Do you get enough vitamin B-12? - MSNBC, 11/18/05 -
"Now, a new concern about vitamin
B-12 has arisen. It seems that adults over the age of 50 may have a reduced
ability to absorb it ... A high intake of folate from fortified grains can
hide the changes in red blood cells that show a lack of vitamin B-12"
- See
iHerb
or
Vitacost
Vitamin B12 products.
-
Veggies May Keep an Aging Brain Sharp - WebMD, 9/28/05
-
Leafy Green Vegetables May Help Keep Brains Sharp Through Aging -
Science Daily, 9/26/05 - "men who
obtained more folate in their diets showed significantly less of a decline
in verbal fluency skills over the course of three years than did men with
lower dietary folate intake ... High folate levels, both in the diet and in
the blood, also appeared to be protective against declines in another
category of cognitive skills known as spatial copying"
-
Folates More Effective In Limiting Alzheimer's Disease Risk
Than Antioxidants, Other Nutrients - Science
Daily, 8/17/05 -
"folates appear to have
more impact on reducing Alzheimer's risk than vitamin E, a noted
antioxidant, and other nutrients considered for their effect as a
brain-aging deterrent"
- See
iHerb
or
Vitacost
folic acid products.
-
Folate May Reduce Risk of Alzheimer's Disease - WebMD, 8/15/05 -
"older adults whose total folate
intake (diet and supplement) equaled or exceeded the 400 microgram RDA
reduced their chances of developing Alzheimer's disease by 55%" - See
iHerb
or
Vitacost
folic acid products.
-
Supplemental Chromium Picolinate and Biotin Appear to Decrease Blood Glucose
and Lipid Levels in Type 2 Diabetics: Presented at ADA - Doctor's Guide,
6/17/05 - "Our most important
finding is that chromium picolinate and biotin help to decrease hemoglobin
A1c [HbA1c] values in poorly controlled diabetics ... 600 mcg chromium
picolinate and biotin 2 mg/per day" - See
iHerb
or
Vitacost
biotin products.
-
Vitamin B6 May Help Prevent Colorectal Cancer - Medscape, 6/10/05 -
"those in the highest quintile had a
34% lower risk of colorectal cancer (multivariate rate ratio"
-
High vitamin B intake cuts risk of colorectal cancer - Nutra USA, 6/6/05
-
Vitamin B-6 May Help People Avoid Colon Cancer - WebMD, 5/3/05 -
"The risk of colorectal cancer was
44% lower for the women with the highest blood level of vitamin B-6 compared
with women with the lowest level of vitamin B-6"
-
Fight Osteoporosis: Bone Up On B12 - Science Daily, 4/23/05 -
"This study suggests adequate
vitamin B12 intake is important for maintaining bone mineral density"
-
Folate and Vitamin B12 Prevent Hip Fracture in Stroke Patients -
Medscape, 3/25/05 - "The magnitude
of benefit is similar to that found in trials of alendronate and raloxifene,
with considerably less potential risk. The fact that BMD did not change
suggests the benefit derives from quality, rather than quantity, of bone"
-
B Vitamins
(including Thiamin, Niacin, B-6, B-12, Riboflavin and Folate) review -
ConsumerLab.com, 4/5/05
- Folic acid:
It's not just for your baby’s health - MSNBC, 4/4/05 -
"The younger group of women (ages 25
to 42) who consumed 1000 micrograms of folic acid through foods and
supplements had a 46 percent decrease in their risk of developing
hypertension as compared to those women who consumed less than 200
micrograms ... older group of women (ages 30 to 55) 1000 micrograms of folic
acid was found to decrease risk of developing hypertension to a lesser
extent — 18 percent"
- See
iHerb
or
Vitacost
folic acid products.
- Folic Acid and Vitamin B12 Decrease Risk of Hip Fracture in Stroke Patients
- Doctor's Guide, 3/1/05 - "Patients who took folic acid and vitamin B12 after their stroke had a
reduced risk of hip fracture compared to patients who took placebo"
-
Preventing Heart Disease and Depression with High-Dose Folic Acid - Life
Extension Magazine, 3/05 - "High-dose folic acid—up to 5000 mcg daily—is a scientifically substantiated
and safe nutritional approach to achieving optimal health in men and women
who want to prevent or reverse chronic illness. With demonstrated benefits
in reducing cardiovascular risk factors, preventing and enhancing treatment
outcomes in depression, and preventing cancer, folic acid is highly
indicated as a therapeutic ally for men and women of all ages"
- Folic Acid May Prevent Hypertension in Addition to Reducing the Risk of
Birth Defects - Doctor's Guide, 2/24/05 - "younger women who consumed at least 1,000 micrograms per day of total folic
acid (dietary plus supplemental) had a 46 percent decreased risk of
hypertension, compared with those who consumed less than 200 micrograms a
day of total folic acid. Older women with high total folic acid intake also
had an 18 percent reduced risk of hypertension"
- Folate Lowers Risk of High Blood Pressure - WebMD,
10/11/04 - "Young women with very
low dietary folate who got their folate from vitamin supplements had a 39%
lower risk of
high blood pressure compared with young women
who did not take folate supplements"
- High Vitamin B12 Levels May be Linked to Better Treatment Outcome for Major
Depressive Disorder - Doctor's Guide, 1/5/04 - "Low levels of folate have also been associated with a poor response to
antidepressive therapy ...
patients with greater
HDRS
responses had higher vitamin B12 levels both at baseline (r
= 0.39, P < .001) and at 6 months ... The positive relationship between
higher vitamin B12 levels and improved
HDRS
score was also confirmed by linear regression analysis" - [Abstract]
-
Vitamin B12 might be an answer for depression - Time Magazine, 12/15/03
- "the patients who responded best
to treatment were those who had higher concentrations of B12 in their blood"
- Folic Acid Cuts Children's Cancer - WebMD, 9/29/03
- "neuroblastoma
rates dropped by 60% since folic acid was added to flour"
-
The Chromium Connection - Natural Foods Merchandiser, 9/03 -
"The body requires certain nutrients to control glucose metabolism,
especially
chromium, zinc and vitamins B and
C" - See
iHerb
or
Vitacost
chromium products.
- Cancer Fighter: Vitamin B-6 - Physician's Weekly,
8/11/03 -
"Washington State University researchers suggest that consuming more vitamin
B-6 can ward off cancer. The vitamin converts folate to a form the body can
use to produce thymine, a component of DNA"
- Higher Folate Levels Correlate with Improved Outcome for SSRI-Treated
Geriatric Patients - Doctor's Guide, 7/16/03 -
"Geriatric patients who are treated with the selective
serotonin reuptake inhibitor (SSRI)
sertraline appear to experience greater improvement in depression if they
have higher than normal folate levels at the start of therapy"
- Vegetarian Diet and B12 Deficiency - WebMD,
6/18/03 - "92% of the vegans they
studied -- those who ate the strictest vegetarian diet, which shuns all
animal products, including milk and eggs -- had vitamin B12 deficiency. But
two in three people who followed a vegetarian diet that included milk and
eggs as their only animal foods also were deficient"
- Low Folate Concentrations Associated With Depression
- Doctor's Guide, 5/2/03 -
"Physically healthy people who are
depressed have detectably lower folate status than those who are not
depressed" - See
iHerb
or
Vitacost
folic acid products.
- Adding Folates Alters Methotrexate Treatment In Rheumatoid Arthritics
- Doctor's Guide, 4/21/03 - "The
researchers found the addition of folates to
MTX treatment was strongly linked with lack of
hepatotoxicity"
- B-Vitamins Prove Effective In Relieving Chronic Pain
- Intelihealth, 4/10/03 -
"B-vitamins, such as thiamin (B1), pyridoxine (B6), and cyanocobalamin
(B12), have been proven to be clinically effective in treating various
painful conditions such as lumbago, sciatica, trigeminal neuralgia,
facial paralysis and optic neuritis as acting as an analgesia (pain
reliever)"
- Folate, Vitamin B6 Reduce Breast Cancer Risk Among Moderate Drinkers
- WebMD, 3/4/03 - "They found women
with the highest folate levels were 27% less likely to have
breast cancer than those with the lowest folate
levels. And the reduction in breast cancer risk was much greater among women
who drank about one glass of wine or a cocktail per day. These moderate
drinkers with high folate levels were 89% less likely to develop breast
cancer than those who drank less than one drink per day ... Women with high
levels of vitamin B6 also had about a 30% lower risk of breast cancer than
those with low levels of this nutrient. Although high levels of vitamin B12
seemed to protect premenopausal women against breast cancer, the effect was
not found among postmenopausal women"
- Alzheimer's Disease and Dementia: Vitamins Can Help Prevent
- WebMD, 2/28/03 -
"High levels of a substance in the blood called
homocysteine tops the list of potentially
new risk factors for heart disease,
stroke, and now dementia. A new study
suggests that high homocysteine levels are linked with mental declines
associated with Alzheimer's disease in elderly people ... High homocysteine
levels can be treated very easily with vitamins, including folate,
niacin, and B-12"
- Low Levels of Serum Vitamin B May Be Related to Helicobacter Pylori
Infection - Doctor's Guide, 2/14/03 -
"Of 25 subjects with vitamin B >145-180 pg/mL,
92% were seropositive
... Eighty-nine percent of the 47 subjects with vitamin B greater than
180-250 pg/mL
were found to be seropositive
compared with 51%, 31 out of 61, of subjects with B less than 250 pg/mL"
- [abstract]
- See the abstract. I think they are talking about vitamin B12.
- Canadian Folic Acid Supplementation Cuts in Half the Rate of Neural Tube
Defects - Doctor's Guide, 12/19/02 -
"A Canadian public-health initiative to enrich cereal grain foods with folic
acid has halved the prevalence of neural-tube defects among both unborn and
newborn children"
- Folic Acid Improves Endothelial Function And Blood Pressure In Smokers
- Doctor's Guide, 12/18/02 - "Smokers
were randomly assigned to receive either 5 milligrams of folic acid or
placebo every day ... Mean blood pressure
was significantly reduced from 88 ± 2 to 83 ± 1 mmHg in those patients who
received supplementation" - Seems like they could have tested
non-smokers for the same effect while they were at it. 5 points is
probably half of what you'd get from the standard dose of most
anti-hypertensive medications. - Ben
- Mechanisms Differ Between Depression and Either Vitamin B12 Or Folate
- Doctor's Guide, 12/10/02 - "hyperhomocysteinemia,
vitamin B12 deficiency and, to a lesser extent, folate
deficiency all were related to depressive
disorders"
- I’ve heard
that receiving weekly B-12 shots can help your metabolism. Any truth to it?
- Dr. Weil, 12/4/02
- Argument Strengthens For Folic Acid To Reduce Homocysteine Level
- Doctor's Guide, 11/26/02 - "A
decrease in serum
homocysteine of 3 micromol/l,
which can be achieved by a daily intake of about 0.8 mg folic acid, should
reduce the risk of ischaemic
heart disease by 16 percent,
deep vein thrombosis by 25 percent, and stroke
by 24 percent" - See
iHerb
or
Vitacost
folic acid products.
-
Folic Acid for Your Heart - WebMD, 11/22/02 -
"By increasing folic acid intake and thus decreasing
homocysteine, the researchers say the risk of
heart disease would drop by 16%,
blood clots in the legs by 25%, and stroke
by 24%" - See
iHerb
or
Vitacost
folic acid products.
- Folic Acid Could Prevent Heart Disease -
Intelihealth, 11/22/02
-
More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical
Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy
for reducing Alzheimer's disease (AD) risk
that includes low fat intake and high consumption of
fish and antioxidants, along with
vitamin E, folic acid, and vitamins B6 and B12
supplements"
-
Low Folic Acid Linked to Miscarriage - WebMD, 10/15/02
- B
Vitamins Protect Heart Patients: The Best Evidence Yet
- New Hope Natural Media, 9/12/02
- Folic Acid May Have Benefits for Smokers -
Doctor's Guide, 9/13/02 - "randomised
to four weeks of folic acid 5 mg/day or placebo ... Results showed that folic
acid reduced homocysteine concentrations
(10.8+/-0.6 versus 7.9+/-0.5 µmol/L, p<0.001) and there was a significant
reduction in blood pressure (mean BP 88+/-2
versus 83+/-1 mmHg, p<0.01) ... Benefits also seem to be largely independent
of the lowering of homocysteine concentrations"
- Homocysteine-Lowering Therapy [folic acid, vitamin B12 and vitamin B6]
Improves Revascularisation, Angioplasty Outcome -
Doctor's Guide, 8/28/02
- Natural
Remedies for Osteoarthritis: Now, More than Ever -
New Hope Natural Media, 8/15/02 -
"Some doctors recommend niacinamide (vitamin B3)"
- Older Vegetarians Should Take Extra Vitamin B12 -
Doctor's Guide, 8/7/02 - "Forty-two
percent of participants had definite
vitamin B12 deficiency, defined as vitamin B12
level less than 150 pmol/L and MMA ł 0.4 µmol/L. Another 32.8 percent of the
women had possible vitamin B12 deficiency" - See
iHerb
or
Vitacost
Vitamin B12 products.
- Folate Supplements May Help Restore Endothelial Function In Type 2 Diabetics
- Doctor's Guide, 8/1/02
-
New Views on Atherosclerosis - Life Extension Magazine, 8/02 -
"A drug company has patented a product called
FOLTX that cardiologists are
now prescribing to their patients for the purpose of lowering
homocysteine. Each tablet of
FOLTX contains: 2.5 mg of
folic acid, 1.0 mg of vitamin B12, 25 mg of vitamin B6. The cost for
90 tablets of FOLTX
from
www.drugstore.com
is $38.08—or about double the retail price of these same potencies of
vitamins when purchased in a health food store"
-
Folic Acid Fights Colon Cancer - WebMD, 7/19/02
- Folic Acid Supplement Reduces Cell Proliferation In High Risk Colorectal
Cancer Patients - Doctor's Guide, 7/18/02 -
"Patients at high risk of
colorectal cancer could cut their risk
dramatically with a daily supplement of 2 mg of folic acid" - See
iHerb
or
Vitacost
folic acid products.
- Higher Folate Levels May Help Protect Against Vascular Disease in Children
with Diabetes - Doctor's Guide, 7/18/02 -
"High folate levels may protect children with type I
diabetes from vascular damage"
- Dietary Folate May Reduce Stroke Risk - Medscape,
7/5/02
- Biotin
Supplement Needed During Pregnancy - New Hope
Natural Media, 6/20/02 -
"Preliminary studies have suggested that biotin in large amounts (such as 5
to 16 mg per day) can help control blood sugar levels or improve nerve
damage in diabetics. In a study of individuals with dry, splitting nails,
supplementation with 2.5 mg of biotin per day improved the quality of the
nails in 63% of those treated. Improvement was seen after an average of two
months, although some individuals did not see results until they had taken
biotin for four months." - Note: Biotin is expensive so most multi's cut you short on that B vitamin.
- Herbal Assisted Weight Loss Causes Neurological Ailment In Woman
- Intelihealth, 6/11/02 -
"The disorder is known to stem from a deficiency of vitamin B1, or thiamine,
essential for carbohydrate metabolism"
- An Anti-Atherosclerosis Aid For Adults With Hyperhomocysteinemia?
- Doctor's Guide, 6/7/02 -
"One year of folic acid supplementation was found to be linked with a
significant increase in the subjects' mean plasma folate levels and a
significant decline in their homocysteine
levels ... Study authors suggest the findings demonstrate long-term folic
acid improves arterial endothelial function and has potential implications
for prevention of atherosclerosis in people with hyperhomocysteinemia"
-
Women Unaware of Folic Acid Benefits - WebMD, 6/4/02 -
"only 31% of women between the ages of 18 and 45 take a folic acid
supplement every day, despite the fact that the vitamin has been shown to
dramatically reduce the risk of serious birth defects ... In fact, only 10%
of women realize that the B vitamin folic acid must be taken prior to
pregnancy to prevent birth defects of the brain and spine known as neural
tube defects ... it takes about a month for the vitamin to provide the
maximum benefit"
- Low Vitamin B Status Prevalent In Alzheimer Patients
- Doctor's Guide, 6/4/02 -
"low vitamin B6 status is prevalent in patients with
AD"
-
Vitamins Fight Alzheimer's - WebMD, 5/28/02 -
"There's new evidence that a substance found in blood can cause the type of
brain and blood vessel deterioration that leads to
dementia. But those same studies also show
that taking certain vitamins can lower levels of this substance --
homocysteine -- and ward off the damage, possibly preventing Alzheimer's
disease ... This is exciting information, because homocysteine levels can be
reduced by taking the vitamins B6, B12, and folic acid"
- Homocysteine Levels Higher, Serum Vitamin B12 Lower In Vegetarians
- Doctor's Guide, 5/27/02 -
"Vegetarians have considerably higher levels of total plasma
homocysteine, greater prevalence of
hyperhomocysteinemia and
lower levels of serum vitamin B12 than do non-vegetarians"
- Serum Folate And Estradiol Levels Interact In Alzheimer's Disease
- Doctor's Guide, 5/13/02 - "a high
ratio of
estradiol to total estrogens is linked with
AD. At the same time, in women with a high ratio, the severity of
dementia is lower in those with high serum folate levels ... If this
association is causal, then supplementation with folic acid may have a role
in future studies of estrogen replacement therapy (ERT)
in Alzheimer's disease (AD)"
- Homocysteine, B Vitamins Associated With Cognitive Function In The Elderly
- Doctor's Guide, 5/10/02
- Adjunct Folinic Acid For Depressed Patients With Inadequate SSRI Response
- Doctor's Guide, 5/8/02 -
"Investigators report that patient folate levels rose. Hamilton
Depression Rating Scale-17 (HAM-D-17) scores among 16 patients who
completed the study decreased"
-
Foods Rich In Folate May Reduce Risk Of Stroke - Intelihealth, 5/3/02
-
Folate Fights Stroke and Heart Disease - WebMD, 5/2/02 -
"people who consumed at least 300 mcg of folate every day had a 20% lower
risk of stroke
and a 13% lower risk of cardiovascular
disease than those consuming less than 136 mcg of folate per day ...
Folate is also thought to offset risk of cardiovascular disease, by reducing
levels of homocysteine in the blood.
Homocysteine is linked with higher risk of atherosclerosis because it
damages arteries, but vitamins B-6 and B-12, as well as folic acid, have
been found to prevent that damage from occurring"
-
Foods Rich In Folate May Reduce Risk Of Stroke - Intelihealth, 5/2/02
-
Nutrition Affects Thinking in Elderly - WebMD, 4/25/02 -
"In this study of healthy elderly people, higher concentrations of folic
acid and vitamin B-12 were associated with increased
memory and thinking ability"
-
Supplements Boost Sperm Count - WebMD, 3/20/02 -
"Researchers found that the men with fertility problems who took 5 mg of
folic acid a day and 66 mg of zinc sulfate a day for 26 weeks had a 74%
increase in total normal sperm count"
-
Folic Acid May Help Prevent Alzheimer's - WebMD, 3/1/02
- Folic Acid Possibly A Key Factor In Alzheimer's Disease Prevention
- Intelihealth, 3/1/02
-
In
Praise of Folic Acid - Time Magazine, 2/25/02 -
"folic acid plays a crucial role in the development of just about every cell
in the body ... subjects who had high levels of a particular amino acid
called homocysteine in their blood were
twice as likely to develop Alzheimer's as
those who didn't. The finding is important because one of the easiest ways
to lower homocysteine levels is to get plenty of folic acid ... There is no
risk of overdose, although high levels of folic acid can mask the signs of
pernicious anemia in people who have developed the disorder" - The
way I understand it, taking vitamin B12 with the folic acid will avoid that
problem. - Ben
-
New Alzheimer's Risk Factor Identified - WebMD, 2/13/02 -
"High blood levels of a substance called homocysteine have been linked to an
increased risk for both heart attack and stroke. Now, new research finds it
to be a major risk factor for Alzheimer's disease and other age-related
dementias ... It is known that B-vitamins like folic acid, B-6, and B-12
lower homocysteine levels"
-
Mix B-12 and Folic Acid for Heart Health - WebMD, 1/18/02 -
"Folic acid alone reduces the level of a potentially harmful amino acid in
the blood, called "homocysteine." When elevated, homocysteine has been shown
to raise the risk of heart disease and stroke. In fact, some heart experts
consider homocysteine to be a very important risk factor ... But adding
vitamin B-12 to the mix "is likely to be much more effective in lowering
homocysteine concentrations,""
- Vitamin B12 Plus Folic Acid Significantly Reduces Homocysteine Levels
- Doctor's Guide, 1/17/02 -
"This finding suggests that a fortification policy based on folic acid and
vitamin B12, rather than folic acid alone, is likely to be much more
effective in lowering homocysteine concentrations"
-
Folic Acid [deficiency] Linked to Parkinson's Disease - WebMD, 1/17/02 -
"The latest research shows that mice on a low-folic-acid diet are much more
likely to get Parkinson's disease than mice on a normal diet ... The
researchers were able to finger homocysteine as the likely culprit behind
the loss of brain cells"
-
Pregnancy Vitamins Cut Leukemia in Kids - WebMD, 12/6/01 -
"Moms who used both folic acid and iron supplements in pregnancy were 60%
less likely to have a child develop leukemia"
-
Folic acid and vitamin B12 save lives and money - Life Extension
Magazine, 11/01 - "supplementation
with folic acid and vitamin B12 would result in a tremendous increase in
health and longevity of the American population at a low cost, while saving
24 billion dollars in healthcare costs over the coming decade ... folic acid
could lower homocysteine by 25%; the
addition of vitamin B12 led to a further 7% drop"
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah
Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene,
gamma tocopherol, vinpocetine, SAMe, folic
acid, carnosine,
glutathione, DMAE, Huperzine A,
probiotics, MSM,
secretagogues, arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
- Folate Cost-Effective For Prevention Of Coronary Artery Reblockage
- Intelihealth, 11/29/01 - "The
vitamin therapy included a combination of folic acid (also known as
folate or vitamin B9),
vitamin B12, and vitamin B6. Patients who received the vitamins had
significantly lower levels of homocysteine, and lower rates of restenosis
and cardiac complications"
- High Dose
Oral Folic Acid Acutely Improves Endothelial Function in Coronary Artery
Disease - Doctor's Guide, 11/14/01 -
"Although high-dose folic acid (5 mg daily) improves endothelial function in
CAD patients, it is controversial as to whether this improvement is due to
homocysteine lowering or other direct actions of folic acid"
-
Can a Mix of Chromium and Biotin Help Diabetics Control Blood Sugar? -
WebMD, 10/15/01
-
Memory vitamins - Life Extension Magazine, 9/01 -
"Folate and vitamin B12 work together to enhance cognition"
-
Folic Acid Doesn't Increase Miscarriage Risk - WebMD, 9/6/01
-
Pharmaceutical Drugs Deplete Folic Acid - Nutrition Science News, 9/01
-
Many Women Still Don't Take Folic Acid Before Conception - WebMD, 9/5/01
- Folic
Acid/Vitamin B12 Show Potential as Heart Disease Treatments
- Doctor's Guide, 8/22/01
-
Battling Heart Disease with B Vitamins - Life Extension Magazine, 8/01 -
"Studies to date have shown that folic acid alone may reduce heart disease
risk by as much as 30% to 40%, primarily through its ability to lower
homocysteine. In fact, folic acid has been deemed the mainstay of treatment
for hyperhomocysteinaemia (elevated homocysteine).(5) However, folic acid
works best when teamed up with vitamin B12, which enhances the benefits of
folic acid supplementation"
- Could
Nicotinamide And Vitamin E Have Synergistic Effect And Reduce Insulin Usage?
- Doctor's Guide, 7/11/01 - "The
combination of nicotinamide and vitamin E might have a synergistic effect in
lowering daily insulin usage among newly diagnosed Type 1 diabetics"
- Alzheimer's
Disease May Be Linked to Deficiencies in Vitamin B12 or Folate
- Doctor's Guide, 5/8/01
-
Folic Acid May Reduce Age-Related Memory Problems - WebMD, 4/27/01 -
"High homocysteine levels were independently associated with poor
performance on the memory tests, as were low levels of the vitamin folic
acid. Folic acid, or folate, has been shown to significantly lower
homocysteine levels ... a cocktail of three vitamin supplements -- folic
acid, B12, and B6 -- can dramatically lower homocysteine levels, even in
those who get the recommended levels of the vitamins in their diets ...
Homocysteine levels naturally increase as you age ... Jacobsen, 62,
recommends taking 400-800 mcg of folic acid every day and 25-100 mg of
vitamin B6. He says it is not clear if B12 supplementation is beneficial in
younger people, but it does appear to benefit those over 50. He takes 500
mcg of B12 each day"
- Decreased
Memory After Age 60 Linked To High Homocysteine Levels - Doctor's Guide,
4/26/01 - "High circulating levels
of homocysteine, especially with
increasing age, have been associated with cognitive impairment. In recent
studies, Alzheimer disease and dementia
after multiple strokes have been linked to extremely high serum homocysteine
concentrations ... The folate status of the
participants was an important consideration because folate has been shown to
significantly modify homocysteine levels"
-
Multivitamin With Folic Acid May Reduce Homocysteine More Than With Folic
Acid Alone - Doctor's Guide, 4/20/01 -
"the supplement containing 800 micrograms of folic acid reduced homocysteine
levels by nearly 50 percent while the supplement containing 160 micrograms
of folic acid had no significant effect above placebo"
-
Pre-conception Advice on Folic Acid Supplementation Recommended -
Doctor's Guide, 4/16/01 - "Only
about one-quarter of pregnant women currently begin folic acid
supplementation early enough to reduce the risk of neural tube defects"
-
Synthetic Folate Trumps Food Form - Nutrition Science News, 3/01 -"folic
acid may reduce the risk of cardiovascular disease via its ability to reduce
homocysteine, an undesirable blood protein. It also prevents birth defects,
which a new finding says may be attributed, in part, to folic acid's ability
to reduce circulating homocysteine levels ... natural folic acid does not
match up to synthetic"
-
Sustain the Brain - Nutrition Science News, 2/01
-
Vitamins May Help Patients With High Homocysteine Levels - Doctor's
Guide, 12/18/00
-
Folic Acid and Vitamin B-12 May Help Prevent Heart Disease - WebMD,
12/11/00
-
Vitamin B12: Surprising New Findings - Life Extension Magazine, 12/00
-
Study confirms benefits of folic acid in pregnancy - CNN, 11/30/00
-
Folic Acid Strikes Again, Study Shows Vitamin Protects Against Birth Defects
Linked to Common Drugs - WebMD, 11/29/00
-
Folic Acid Supplementation Reduces Methotrexate Complications - Doctor's
Guide, 10/30/00
-
Americans May Be Low in B12 - Nutrition Science News, 10/00
-
Women Need a Folic Acid Fix - WebMD, 10/3/00
-
Folic Acid Reduces Defects - Intelihealth, 10/3/00
-
Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00
- "Another sad case of drug-induced
nutrient deficiency involves the depletion of folic acid (also known as
folate and folacin) by a myriad of commonly used drugs. These include
aspirin and other salicylates, ibuprofen, indomethacin and other
non-steroidal anti-inflammatories. Celebrex unfortunately also depletes
folic acid. Methotrexate, used in the treatment of rheumatoid arthritis and
various cancers such as leukemia and lymphoma, is notorious for depleting
folic acid. Likewise, the use of corticosteroids, barbiturates such as
phenobarbitol, sulfa drugs such as Bactrim, certain antibiotics, diuretics
and oral contraceptives can cause a deficiency of folic acid. The widely
used anticonvulsive drug Dilantin (phenytoin) and related drugs also deplete
folic acid."
-
Folic Acid and the Heart Turning Into Fast Friends - WebMD, 8/31/00
-
3 B's Block Cardiovascular Disease - Nutrition Science News, 7/00
-
Fish Oil, Vitamin B-12 May Offer Relief During That Time of the Month -
WebMD, 6/20/00
- Nicostatin
(Niacin/Lovastatin) Reduces Cholesterol, Triglyceride Levels - Doctor's
Guide, 3/16/00
- Niaspan
(Niacin Extended-Release) Raises HDL Twice As Much as Gemfibrozil -
Doctor's Guide, 3/14/00 (Note: Extended release niacin
has been shown to cause liver damage).
-
Gemfibrozil-Niacin Combination Greatly Increases Good Cholesterol -
Doctor's Guide, 3/10/00
-
Niacin for Achy Joints - Nutrition Science News, 11/99
-
Folic Acid May Fight Down Syndrome - Intelihealth, 9/29/99
- Study Links
Vitamin B Deficiency To Risk Of Stroke In Younger Women
- Doctor's Guide, 8/30/99
-
Study Finds "New" Cholesterol (Homocysteine) Is Key To Heart Disease -
Intelihealth, 5/19/99
- Thiamine
Deficiency Linked To Malaria - Doctor's Guide, 2/12/99
-
March of Dimes promotes B vitamin to curb birth defects - CNN, 1/28/99
- Folic Acid
During Pregnancy Does Not Cause Multiple Births - Doctor's Guide,
1/22/99
-
Thiamine's Mood-Mending Qualities -
Nutrition Science News, 1/99
- Elevated
Homocysteine Levels May Be Possible Risk Factor For Alzheimer Disease -
Doctor's Guide, 10/20/98
-
Study: Vitamin B-6 may help reduce heart disease - CNN, 7/20/98
- Homocysteine
A Possible Risk Factor For Alzheimer's - Doctor's Guide, 4/29/98
-
Study: Folic acid boost could save 50,000 lives a year - CNN, 4/9/98
- Report Urges
Supplemental Folic Acid For Women of Childbearing Age - Doctor's Guide,
4/8/98
- Natural
Sugar-Phosphate Compound Shows Promise In Cancer - Doctor's Guide,
3/30/98 (See IP-6)
- B-Vitamins
May Reduce Vessel Damage In Stroke Patients - Doctor's Guide, 2/9/98
-
Advice to childbearing-age women: Take more folic acid - CNN, 2/18/97
Abstracts:
-
Effect
of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal
breast cancer women with special reference to blood chemistry profiles -
Breast Cancer Res Treat. 2008 Apr 22 - "Tamoxifen (TAM)
... TAM also has estrogenic activity on liver and endometrium causing severe
oxidative stress with various biochemical derangements. Coenzyme Q(10),
Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective
agents against many diseases including cancer ... A statistically significant
alteration in various blood chemistry parameters, such as serum total bilirubin
(S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate
pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric
acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases
(LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was
favorably reverted back to near normal levels on combinatorial therapy with CoRN"
- See
coenzyme Q10 products at iHerb
.
-
Folate
and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial - Cancer
Causes Control. 2008 Mar 6 - "Low dietary folate intake
has been associated with colorectal cancer risk and adenoma recurrence. A C/T
transition at position 677 in the gene encoding methlylenetetrahydrofolate
reductase (MTHFR C677T) has been reported to interact with folate intake to
modulate colorectal adenoma recurrence or cancer risk ... In general, no
statistically significant associations were found between quartile of folate
intake (dietary or total) and adenoma recurrence ... No significant interaction
was noted for total folate and MTHFR genotype, though an increased risk of
recurrence noted for the MTHFR CT genotype was statistically significant only
for those individuals with below median intake of total folate"
-
Is folic acid good for
everyone? - Am J Clin Nutr. 2008 Mar;87(3):517-33 -
"Folate has a dual effect on cancer, protecting against cancer initiation but
facilitating progression and growth of preneoplastic cells and subclinical
cancers"
-
Hepatoprotective effect of vitamin b(12) on dimethylnitrosamine-induced liver
injury - Biol Pharm Bull. 2008 Feb;31(2):309-11 -
"Vitamin B(12) decreased the blood levels of aspartate aminotransferase and
alanine aminotransferase, and clearly inhibited the overaccumulation of collagen
fibrils ... vitamin B(12) could be an effective hepatoprotective agent" -
Note: Aspartate aminotransferase is the AST reading on blood tests and
alanine aminotransferase is the ALT.
-
Effects
of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial
function in patients with coronary artery disease - Acta Cardiol. 2007
Dec;62(6):579-85 - "either folic acid 5 mg or NAC 600 mg
or placebo daily for eight weeks ... endothelium-dependent dilation (EDD) ...
Folic acid and NAC therapies decreased plasma homocysteine (from 21.7 +/- 8.7
micromol/l to 12.5 +/- 2.5 micromol/l, P < 0.001; from 20.9 +/- 7.6 micromol/l
to 15.6 +/- 4.3 micromol/l, P = 0.03, respectively), and increased EDD (6.7 +/-
6.1% P = 0.002, 4.4 +/- 2.6% P < 0.001, respectively) compared with placebo.
There was no significant difference in improving EDD between the folic acid and
the NAC group"
-
Dietary
vitamin b6 intake and the risk of colorectal cancer - Cancer Epidemiol
Biomarkers Prev. 2008 Jan;17(1):171-82 - "Moderately
strong inverse and dose-dependent associations in the whole sample were found
between CRC risk and the intake of dietary and total vitamin B6 in all three
models [model III: odds ratio (OR), 0.77; 95% confidence interval (95% CI),
0.61-0.98; P for trend = 0.03; OR, 0.86; 95% CI, 0.69-1.07; P for trend = 0.12].
In addition, meta-analyses of published studies showed inverse associations
between vitamin B6 and CRC (combined relative risk, 0.81; 95% CI, 0.68-0.96;
test for overall effect P = 0.01; combined odds ratio, 0.67; 95% CI, 0.60-0.75;
test for overall effect P < 0.00001)"
-
Folic
acid supplementation in early second trimester and the risk of preeclampsia
- Am J Obstet Gynecol. 2008 Jan;198(1):45.e1-7 -
"Supplementation of multivitamins containing folic acid was associated with
increased serum folate (on average 10.51 micromol/L), decreased plasma
homocysteine (on average 0.39 micromol/L), and reduced risk of preeclampsia
(adjusted odds ratio, 0.37; 95% confidence interval, 0.18-0.75)" - See
iHerb
folic acid products.
-
Vitamin B6 treatment for tardive dyskinesia: a randomized, double-blind,
placebo-controlled, crossover study - J Clin Psychiatry. 2007
Nov;68(11):1648-54 - "The mean decrease in ESRS clinical
global impression scores from baseline to endpoint was 2.4 points in patients
treated with vitamin B(6) and 0.2 points in patients treated with placebo (p <
.0001). The mean decrease in the parkinsonism subscale score was 18.5 points and
1.4 points, respectively (p < .00001), and the mean decrease in the dyskinesia
subscale score was 5.2 points and -0.8 points, respectively ... Vitamin B(6)
appears to be effective in reducing symptoms of TD. The specific mechanisms by
which vitamin B(6) attenuates symptoms of TD are not clear"
-
Association of folate intake with the occurrence of depressive episodes in
middle-aged French men and women - Br J Nutr. 2007 Dec 6;:1-5 -
"the risk of experiencing recurrent depressive episodes
(two or more) during the follow-up was strongly reduced in men with high folate
intake (OR 0.25 (95 % CI 0.06, 0.98) for the highest tertile v. the lowest" - See
iHerb
folic acid products.
-
Low vitamin B-12 status and risk of cognitive decline in older adults - Am J
Clin Nutr. 2007 Nov;86(5):1384-91 -
"concentrations of holoTC (a marker of reduced vitamin B-12 status), tHcy, and
MMA predicted cognitive decline, but folate did not. A doubling in holoTC
concentrations (from 50 to 100 pmol/L) was associated with a 30% slower rate of
cognitive decline (-0.137 to -0.083), whereas a doubling in tHcy (from 10 to 20
mumol/L) or MMA (from 0.25 to 0.50 mumol/L) was associated with >50% more rapid
cognitive decline (-0.090 to -0.169) and (-0.104 to -0.169), respectively"
- See
iHerb
vitamin B12 products.
-
Low vitamin B-12 status and risk of cognitive decline in older adults - Am J
Clin Nutr. 2007 Nov;86(5):1384-91 - "Low vitamin B-12
status was associated with more rapid cognitive decline"
-
Homocysteine, vitamins, and vascular disease prevention - Am J Clin Nutr.
2007 Nov;86(5):1563S-8S - "Dietary deficiency of vitamin
B-6 and folic acid and absorptive deficiency of vitamin B-12, which result from
traditional food processing or abnormal absorption of B vitamins, are important
factors in causing elevations in blood homocysteine. Numerous clinical and
epidemiologic studies have established elevated blood homocysteine as a potent
independent risk factor for vascular disease in the general population. Dietary
improvement, providing abundant vitamin B-6, folic acid, and cobalamin, may
prevent vascular disease by lowering blood homocysteine. The dramatic decline in
cardiovascular mortality in the United States since 1950 may possibly be
attributable in part to voluntary fortification of the food supply with vitamin
B-6 and folic acid. Fortification of the US food supply with folic acid in 1998,
as mandated by the US Food and Drug Administration, was associated with a
further decline in mortality from vascular disease, presumably because of
increased blood folate and decreased blood homocysteine in the population"
-
Low vitamin B6 and folic acid levels are associated with retinal vein occlusion
independently of homocysteine levels - Atherosclerosis. 2007 Oct 16 -
"Retinal vein occlusion (RVO) is one of the most common
retinal vascular disorders ... Blood levels of vitamin B6, folate and Hcy, but
not of vitamin B12, were found to be significantly different in patients as
compared to healthy subjects. At the univariate analysis, the lowest tertile of
vitamin B6 [odds ratio (OR) 4.03; 95% confidence interval (CI) 2.58-6.31;
P<0.0001)] and folate (OR 6.13; 95% CI 3.85-9.76, P<0.0001), and the highest
tertile of Hcy (OR 8.08; 95% CI 5.05-12.92, P<0.0001) were found to be
significantly associated with RVO. Moreover, at multivariate analysis, after
adjustment for traditional cardiovascular risk factors, Hcy, and circulating
levels of vitamins, respectively, the lowest tertile of vitamin B6 (OR 3.29; 95%
CI 1.89-5.70, P<0.0001) and folate (OR 5.41; 95% CI 3.08-9.51, P<0.0001) and the
highest tertile of Hcy (OR 2.58; 95% CI 1.12-5.94, P<0.0001) maintained their
significant association with RVO"
-
Augmenting antidepressants with folate: a clinical perspective - J Clin
Psychiatry. 2007;68 Suppl 10:4-7 - "Folate in particular
has been found to further reduce symptoms in patients with depression when used
in conjunction with an antidepressant, and because folate is a water-soluble B
vitamin, its safety and tolerability are well established. This strategy would
typically be used in patients with low plasma or red blood cell folate levels.
Folate augmentation may be used (1) to enhance the efficacy of antidepressants
in nonresponders, (2) to enable those who partially respond to antidepressant
monotherapy to achieve remission, and (3) to alleviate residual symptoms during
antidepressant treatment" - See
iHerb
folic acid products.
-
The role of folate in depression and dementia - J Clin Psychiatry. 2007;68
Suppl 10:28-33 - "folate deficiencies may be caused by
improper absorption and utilization, often due to genetic polymorphisms.
Individuals, therefore, can have insufficient levels or lack needed forms of
folate, despite adequate intake. Supplementation with the active form of folate,
methyltetrahydrofolate, which is more readily absorbed, may be effective in the
prevention and treatment of both depression and dementia" -
iHerb
folic acid products.
-
B Vitamin Plasma Levels and the Risk of Ischemic Stroke and Transient Ischemic
Attack in a German Cohort - Stroke. 2007 Sep 20 -
"Our data suggest that low vitamin B12 plasma levels, particularly in
combination with low folate levels, increase the risk of cerebral ischemia. This
effect may be mediated at least partly through elevations of homocysteine
levels"
-
Prevalence of and risk factors for vitamin B(12) deficiency in patients with
Crohn's disease - Inflamm Bowel Dis. 2007 Sep 20 -
"Vitamin B(12) abnormalities are common in patients with CD and patients with a
prior ileal or ileocolonic resection are at particular risk" - See
iHerb
Vitamin B12 products.
-
Review of the role of hyperhomocysteinemia and B-vitamin deficiency in
neurological and psychiatric disorders - Fortschr Neurol Psychiatr. 2007
Sep;75(9):e1-e18 - "Elevated concentration of total
homocysteine (Hcy) in plasma (> 12 micromol/l) is a risk factor for several
diseases of the central nervous system. Epidemiological studies have shown a
dose-dependent relationship between concentrations of Hcy and the risk for
neurodegenerative diseases. Hcy is a marker for B-vitamin deficiency (folate, B
(12), B (6)). Hyperhomocysteinemia (HHcy) causes hypomethylation which is an
important mechanism that links Hcy to dementia ... Current evidence suggests
that Hcy-lowering treatment has a positive effect for the secondary and primary
prevention of stroke. HHcy is very common in patients with Parkinson disease
particularly those who receive L-dopa treatment. Furthermore, a positive
association has been reported between HHcy and multiple sclerosis. Moreover,
HHcy and vitamin B deficiency are reported to have a causal role in depression,
and epilepsy. In addition several anti-epileptic drugs cause secondary HHcy.
Therefore, sufficient intakes of the vitamins are recommended for patients who
have already developed neuropsychiatric diseases. Vitamin B deficiency should be
suspected in children with development disorders, failure to thrive and
unexplained neurological manifestations. Elderly people are also an important
at-risk group where vitamin B deficiency and HHcy have been linked to
neurodegenerative diseases. Treatment with folate, B (12), and B (6) can improve
cerebral function. Preventive vitamin B supplementation and sufficient intake
seem very important for secondary and primary prevention of neuropsychiatric
disorders, especially in subjects with a low intake or status of the vitamins"
-
Plasma folate concentration and cognitive performance: Rotterdam Scan Study
- Am J Clin Nutr. 2007 Sep;86(3):728-34 - "After
multivariate adjustment, the mean change in test score per 1-SD increase in
plasma folate was 0.05 (95% CI: 0.01, 0.09) for global cognitive function, 0.08
(95% CI: 0.04, 0.13) for psychomotor speed, and 0.02 (95% CI: -0.04, 0.07) for
memory function ... The odds ratio relating a 1-SD increase in plasma folate to
the presence compared with the absence of severe white matter lesions was 0.79
(95% CI: 0.66, 0.94), whereas no relation was seen between folate status and
hippocampal or amygdalar volume" - See
iHerb
folic acid products.
-
Effect of dietary B vitamins on BMD and risk of fracture in elderly men and
women: The Rotterdam Study - one. 2007 Aug 17 - "As
compared to the three lowest quartiles, individuals in the highest quartile of
age- and energy-adjusted dietary pyridoxine intake had a decreased risk of
non-vertebral fractures (HR=0.77, 95% CI=0.65-0.92, p=0.005) and of fragility
fractures (HR=0.55"
-
Folate: in vitro and in vivo effects on VLDL and LDL oxidation - Int J Vitam
Nutr Res. 2007 Jan;77(1):66-72 - "folic acid
supplementation reduced tHcy and protected both VLDL and LDL against oxidation.
These findings provide further support for the use of folic acid supplements to
aid in the prevention of atherosclerosis"
-
High folate intake is associated with lower breast cancer incidence in
postmenopausal women in the Malmo Diet and Cancer cohort - Am J Clin Nutr.
2007 Aug;86(2):434-43 - "Compared with the lowest
quintile, the incidence of invasive breast cancer was reduced in the highest
quintile of dietary folate intake (HR: 0.56; 95%
CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements
(HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate
equivalents (HR: 0.59" - See
iHerb
folic acid products.
-
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
- Lancet. 2007 Jun 2;369(9576):1876-82 - "Folic acid supplementation significantly reduced the risk of stroke by 18%"
-
Correlations between folate, B12, homocysteine levels, and radiological
markers of neuropathology in elderly post-stroke patients - J Am Coll
Nutr. 2007 Jun;26(3):272-8 - "folate deficiency and
hyperhomocysteinemia are prevalent in elderly post-stroke patients. These
two conditions are strongly and independently associated with the
development of brain atrophy"
-
Blood folate levels and risk of liver damage and hepatocellular carcinoma in
a prospective high-risk cohort - Cancer Epidemiol Biomarkers Prev. 2007
Jun;16(6):1279-82 - "When comparing persons in the
lowest quartile RBC folate to persons in all other quartiles, the analysis
found that higher RBC folate levels were associated with reduced risk of
hepatocarcinogenesis (odds ratio, 0.33" - See
iHerb
folic acid products.
-
Effects of folic acid and vitamin B complex on serum C-reactive protein and
albumin levels in stable hemodialysis patients - Curr Med Res Opin. 2007
Jun 29 - "Folic acid and vitamin B complex
co-administration effectively lowers tHcy and hs-CRP levels and increases
albumin levels in stable hemodialysis subjects, underscoring their potential
benefit to attenuate the state of inflammation and possibly improve the
nutritional status in patients on hemodialysis"
-
Low Intake of Vitamin B-6 Is Associated with Increased Risk of Colorectal
Cancer in Japanese Men - J Nutr. 2007 Jul;137(7):1808-1814 -
"We observed a significant inverse association
between vitamin B-6 intake and colorectal cancer in men. Compared with the
lowest quartile, the multivariate hazard ratio (95% [CI]) in the highest
quartile of intake was 0.69"
-
Effect of folic Acid on endothelial function following acute myocardial
infarction - Am J Cardiol. 2007 Feb 15;99(4):476-81 -
"6-week treatment with high-dose
folic acid improves endothelial function in post-AMI patients, independent
from homocysteine status. Folic acid can be recommended to improve postinfarction endothelial dysfunction in patients with normo- and
hyperhomocysteinemia"
-
Effect of 3-year folic acid supplementation on cognitive function in older
adults in the FACIT trial: a randomised, double blind, controlled trial
- Lancet. 2007 Jan 20;369(9557):208-16 -
"Folic acid supplementation for 3
years significantly improved domains of cognitive function that tend to
decline with age"
-
Vitamin B6 supplementation increases immune responses in critically ill
patients - Eur J Clin Nutr. 2006 Oct;60(10):1207-13 -
"T-lymphocyte and T-helper cell
numbers and the percentage of T-suppressor cell significantly increased on
day 14 in the B6 -50 group. Total lymphocyte count, T-helper and
T-suppressor cell numbers, the percentage of T-lymphocyte cells and
T-suppressors significantly increased in the B6 -100 group at the 14th day"
-
B-vitamins reduce plasma levels of beta amyloid - Neurobiol Aging. 2006
Nov 17 - "Elevated plasma
homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus
B vitamins may have a role in the prevention of AD. The objective of this
study was to determine if tHcy lowering vitamins decrease the circulating
levels of A-beta protein 1-40 (Abeta40). We randomized 299 older men to
treatment with 2mg of folate, plus 25mg of B6 and 400mug of B12, or placebo.
After 2 years of treatment the mean (S.E.) increase of Abeta40 was 7.0pg/ml
(8.4) in the vitamin group (4.9%), and 26.8pg/ml (7.7) (18.5%) in the
placebo group. We conclude that B vitamins may decrease the plasma level of
Abeta40 and have a role in the prevention of AD"
-
High- but not low-dose folic acid improves endothelial function in coronary
artery disease - Eur J Clin Invest. 2006 Dec;36(12):850-9 -
"Both 400 microg day(-1) and 5 mg
day(-1) FA significantly increased plasma folate and decreased plasma Hcy.
The FMD improved significantly after 6 weeks' treatment of 5 mg day(-1) FA
but did not correlate with the reduction in Hcy. There was no change in FMD
in either the 400 microg FA or placebo group"
-
Folic acid improves endothelial dysfunction in type 2 diabetes--an effect
independent of homocysteine-lowering - Vasc Med. 2006 May;11(2):101-9 -
"2 weeks of folic acid
supplementation can improve endothelial dysfunction in type 2 diabetics
independent of homocysteine-lowering" - See
iHerb
or
Vitacost
folic acid products.
-
Folate and vitamin b6 rapidly normalize endothelial dysfunction in children
with type 1 diabetes mellitus - Pediatrics. 2006 Jul;118(1):242-53 -
"High-dose folate and vitamin B(6)
normalized endothelial dysfunction in children with type 1 diabetes. This
effect was maintained over 8 weeks, with no additional benefit from
combination treatment"
-
Loss of vision as a presenting sign of cobalamin deficiency: An eye-opener
- Eur J Intern Med. 2006 Jul;17(4):292-4 -
"We describe a patient who presented
with loss of vision that turned out to be caused by cobalamin deficiency.
Both her vision and her visual field improved upon supplementation of
cobalamin. It is, therefore, important to consider cobalamin deficiency as a
treatable cause of loss of vision" - Note: Cobalamin is vitamin
B12.
-
Older Adults May Need
B12 Dose More Than 200 Times the RDA to Normalize Mild Vitamin Deficiency
- Medscape, 5/26/06 - "As both methylmalonyl-coenzyme A (MMA) and homocysteine are metabolized by vitamin
B12, elevated levels of these compounds in the plasma can reflect vitamin
deficiency ... One analysis yielded 500 μg of vitamin B12 as the minimum
dose necessary to produce the greatest effect on MMA levels. There was
little additional benefit in using daily doses of vitamin B12 of more than
500 μg"
-
Effect of nicotinamide on newly diagnosed type 1 diabetic children -
Acta Pharmacol Sin. 2006 Jun;27(6):724-7 -
"even low doses of oral NA given to
children with newly diagnosed type 1 diabetes may reduce insulin
requirements and prolong the honeymoon period"
-
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12
deficiency: a systematic review of randomized controlled trials - Fam
Pract. 2006 Apr 3 - "The evidence
derived from these limited studies suggests that 2000 microg doses of oral
vitamin B12 daily and 1000 microg doses initially daily and thereafter
weekly and then monthly may be as effective as intramuscular administration
in obtaining short-term haematological and neurological responses in vitamin
B12-deficient patients"
-
Folic acid supplementation for 3 wk reduces pulse pressure
and large artery stiffness independent of MTHFR genotype
- Am J Clin Nutr. 2005 Jul;82(1):26-31 -
"5 mg folic acid/d ... Folic acid reduced brachial pulse pressure by 4.7 ...
Folic acid is a safe and effective supplement that targets large artery
stiffness and may prevent isolated systolic hypertension" - See
iHerb
or
Vitacost
folic acid products.
-
Reducing toxicity of methotrexate with folic acid
- Z Rheumatol. 2005 Jun;64(5):353-8 -
"Folate supplementation should,
the
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