|
|
|
Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
Home >
Anti-aging Research >
Antidepressants > SAM-e
SAM-e (S-adenosylmethionine)
Related Topics:
Specific Recommendations:
News & Research:
-
Adding Nutritional Supplement to Antidepressant Therapy May Boost Response in
Refractory Depression - Medscape, 8/18/10 - "significantly more SAMe-treated
than placebo-treated patients (36.1% vs 17.6%) experienced a clinical response
on the 17-item Hamilton Depression Rating Scale (HAM-D), which was the primary
study outcome. Remission rates (ie, HAM-D score of ≤7) were also higher with
SAMe than with placebo (25.8% vs 11.7%)"
-
Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary
Liver Cancer In Rats - Science Daily, 7/30/09 -
"A new study investigated the effectiveness of S-adenosylmethionine (SAMe)
in the prevention and treatment of hepatocellular carcinoma (HCC) or primary
liver cancer. SAMe, a widely available nutritional supplement, with little
known side effects, was found to be effective in preventing the formation of
HCC in rats" - [Abstract]
-
Can SAM-e Hurt My Heart? - Dr. Weil, 10/10/08 -
"Since SAM-e is ultimately converted in the body to homocysteine, it is
theoretically possible that taking it could elevate homocysteine levels. But
that doesn't happen. In fact, SAM-e actually appears to lower homocysteine
by helping the body metabolize it"
-
SAMe review - ConsumerLab.com, 4/26/07
-
Report: Same - Life Extension Magazine, 4/07
-
Improvement of aggressive behavior and quality of life impairment following
S-Adenosyl-Methionine (SAM-e) augmentation in schizophrenia - Eur
Neuropsychopharmacol. 2008 Sep 26 - "Eighteen
patients with chronic schizophrenia were randomly assigned to receive either
SAM-e (800 mg) or placebo for 8 weeks in double-blind fashion. Results
indicated some reduction in aggressive behavior and improved quality of life
following SAM-e administration. Female patients showed improvement of
depressive symptoms"
-
8 natural
pain relievers - MSNBC, 9/14/08 - "Capsaicin:
For arthritis, shingles, or neuropathy ... InflaThera or Zyflamend: For
arthritis ... Aquamin: For osteoarthritis ... SAM-e (S adenosylmethionine):
For osteoarthritis ... Fish oil: For joint pain from arthritis or autoimmune
disorders ... Methylsulfonyl-methane (MSM): For osteoarthritis"
-
Patients Seek Natural Alternatives to NSAIDs - Clinical Psychiatry News,
7/05 - "SAMe appeared to be as
effective as NSAIDs in reducing pain and improving functionality with fewer
adverse effects than NSAIDS"
-
SAMe - A Natural Compound that Offers Safe, Effective Relief from
Depression, Osteoarthritis, and Liver Disease - Life Extension Magazine,
1/05 - "SAMe
offers arthritis relief without the side effects associated with NSAIDs.
Given its safety and tolerability record, SAMe supplementation is
recommended for anyone interested in maintaining optimal liver function.
Finally, SAMe is a valuable and effective tool for managing depression,
offering a safe, effective alternative to prescription medications"
- SAMe
Bioavailability and Lack of Toxicity in Humans -
Medscape, 12/16/04
-
Small Study Shows SAMe May Improve Treatment Of Depression - Science
Daily, 12/9/04
- Dietary Supplement Ups Antidepressant Effect -
WebMD, 12/2/04 - "Half the patients
in the study reported significant improvement in symptoms when they took
SAMe along with their prescription antidepressant for six weeks. Forty-three
percent reported having no depression symptoms at all six weeks after adding
the dietary supplement to their treatment"
-
S-Adenosylmethionine (SAMe) - A Very Important Natural Product
- Dr. Murray's Natural Facts, 6/2/04 -
"SAMe is perhaps the most effective natural antidepressant (although a
strong argument could be made for the extract of St. John's wort
standardized to contain 0.3% hypericin)" - See
iHerb
or
Vitacost
SAMe products.
- Supplement SAM-e Helps Beat Depression - WebMD,
5/5/04 - "When SAM-e was added to
their usual medication, half of the patients improved and 43% went into
remission, Alpert reports. "These are quite strong responses and remission
rates for a population that failed traditional therapy.""
- S-Adenosyl Methionine May Be As Efficacious As Celecoxib in Management of
Knee Osteoarthritis, But Onset of Action Is Slower
- Doctor's Guide, 5/4/04 -
"During the first month of phase 1,
celecoxib was significantly more effective in reducing pain than was SAMe
(P= .024); however, by the second month of phase 1, patients in both groups
had significant pain improvement from baseline (PS</i>] < .01), and no
significant difference in pain was observed between groups"
-
A New Era for SAMe - Life Extension Magazine, 6/03
- Cirque choreographer promotes new twist on joint health
- USA Today, 9/9/03
- S-Adenosyl-L-Methionine Results Similar to Imipramine in Major Depression
- Doctor's Guide, 12/30/02 - "A
total of 146 patients received 400 milligrams per day of intramuscular
SAMe and 147 received 150 mg/d of oral
imipramine ... SAMe and imipramine did not differ significantly on any
efficacy measure, either main or secondary ... Adverse events were
significantly less in patients treated with SAMe compared to those treated
with imipramine" - Note: There seems to be conflicting studies
on whether oral SAMe is poorly absorbed. I've added absorption studies
near the bottom of my SAMe page. Maybe the difference is "Enteric
coating" tablets.
- SAMe
Beneficial in Treating Osteoarthritis, Depression, and Liver Disease
- New Hope Natural Media, 12/12/02 -
"More than 100 human studies have been published in medical journals showing
that SAMe
is a safe, effective treatment and, in the cases of
depression and osteoarthritis, works as
well as conventional medications"
-
SAM-e Same As Drugs - Functional Foods & Nutraceuticals, 12/02
- Supplement [SAM-e] Found Effective As Antidepressant
- Intelihealth, 11/6/02 - "The
dietary supplement SAMe is about as effective as older, conventional
antidepressants in treating
depression, a preliminary, government-funded study says. It also finds
SAMe to be comparable to non-steroidal anti-inflammatory medications in
treating the pain of osteoarthritis. Such drugs include aspirin, ibuprofen
and naproxen"
- Expert Panel Finds SAMe Promising - WebMD,
10/10/02 - "As a treatment for
depression, SAMe was shown to be as effective as
antidepressants, and more effective
than placebo. SAMe
also had fewer side effects when compared with standard antidepressants ...
As a treatment for
osteoarthritis, SAMe
had fewer digestive side effects than anti-inflammatory drugs like
ibuprofen, yet was effective in relieving pain ...
SAMe
is a natural substance for the body, it's not a designer drug, and therefore
can be carried in, absorbed into pathways," ... The L-dopa medication that
patients take for Parkinson's makes them unusually
SAMe-deficient "because
L-dopa consumes vast quantities of
SAMe, like a sponge, it mops
up all the SAMe
in the body." - See
iHerb
or
Vitacost
SAMe products.
- Government Report Concludes: Dietary Supplement SAM-e Equally Effective as
Prescription Drugs for Depression, Osteoarthritis
- Vitacost/Business Wire, 10/3/02
-
SAMe aids arthritis without side effects - Life Extension Magazine,
10/02
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah
Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene,
gamma tocopherol, vinpocetine, SAMe, folic
acid, carnosine,
glutathione, DMAE, Huperzine A,
probiotics, MSM,
secretagogues, arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
-
Some SAMe Supplements Found Lacking, About Half Had Less of the Active
Ingredient Than Labels Implied - WebMD. 5/29/01 -
"ConsumerLab.com found that about half the 13 products it tested were
accurately labeled as to their SAMe content. Some brands alleged to contain
200 mg actually had about half that, because manufacturers factored in not
just the weight of "free" SAMe -- the "therapeutic" portion -- but also an
inactive SAMe ingredient"
- Caution in Treating PD Depression - Nutrition
Science News, 5/01 - "SAMe
depletes dopamine and can produce PD-like changes in animals, causing cell
degeneration in the nigra
and striatum areas of the brain"
-
Diet, Supplements, Exercise and Sauna - Life Extension Magazine, 9/99 -
"TMG, on the other hand, is very effective at raising the levels of SAMe and
lowering homocysteine."
-
SAMe Needs The B's - Nutrition Science News, 7/00 -
"users of this wonder pill should be aware that through the natural
metabolism of SAMe, the amino acid homocysteine is created--a situation that
can lead to artery damage and even heart disease. . . . .others have
demonstrated that by simply upping one's intake of the vitamins B6, B12 and
folic acid, this potential hazard can be avoided." - Note:
TMG is a precursor to SAM-e and lowers homocysteine instead of raising
it.
-
Depression Protocol - Life Extension Foundation
-
Newsweek magazine, 3/22/99
"...SAM-e appears comparable to
state-of-the-art treatments for both conditions [arthritis and depression].
And unlike the leading drug therapies, it lacks significant side effects.
Dr. Richard Brown [co-author of "Stop Depression Now"] a Columbia University
Psychiatrist describes it as the 'best anti-depressant I've ever
prescribed." "...it's cheaper than many prescription remedies. And if it
lives up to its promise, it may be more valuable."
-
The link between homocysteine levels and SAMe, plus... - Life Extension
Magazine, 1/01
-
S-adenosyl-L-methionine as an Antidepressant, Results of a MEDLINE Search
- Ivan Goldberg, MD
- SAMe
- IAS
-
SAM-e: The antidepressant celebrity - CNN, 10/14/99
-
SAMe Part 4: Treatment for Arthritis - Life Extension Magazine, 9/97
-
SAMe - Part 3: The Liver Super- Nutrient - Life Extension Magazine, 6/97
-
S-Adenosylmethionine (SAMe) - Part 2: Fast-Acting Natural Antidepressant
- Life Extension Magazine, 4/97
-
S-Adenosylmethionine (SAMe) An Exciting New Antiaging Therapy - Life
Extension Magazine, 3/97
Abstracts:
-
S-Adenosyl
Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for
Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind,
Randomized Clinical Trial - Am J Psychiatry. 2010 Jul 1 -
"These
preliminary results suggest that SAMe can be an effective, well-tolerated, and
safe adjunctive treatment strategy for SRI nonresponders with major depressive
disorder and warrant replication"
-
S-adenosylmethionine
in the chemoprevention and treatment of hepatocellular carcinoma in a rat
model - Hepatology. 2009 Apr 6 - "SAMe is
effective in preventing HCC establishment but ineffective in treating
established HCC because of induction of hepatic methyltransferases, which
prevents SAMe level to reach high enough to kill liver cancer cells. SAMe's
chemopreventive effect may be related to its proapoptotic action and its
ability to inhibit angiogenes"
-
Dietary
Supplement S-Adenosyl-l-Methionine (AdoMet) Effects on Plasma Homocysteine
Levels in Healthy Human Subjects: A Double-Blind, Placebo-Controlled,
Randomized Clinical Trial - J Altern Complement Med. 2009 May 7 -
"S-adenosyl-l-methionine (AdoMet), a commonly used
nutritional supplement ... AdoMet at a daily dose of 800 mg for 4 weeks does
not appear to significantly affect Hcy levels in the blood"
-
Efficacy
of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease:
A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension -
Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We
examined the efficacy of a vitamin/nutriceutical formulation (folate,
vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and
acetyl-L-carnitine) in a 12-month, open-label trial with 14
community-dwelling individuals with early-stage Alzheimer's disease.
Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox
1 and 2). Family caregivers reported improvement in multiple domains of the
Neuropsychiatric Inventory (NPI) and maintenance of performance in the
Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL).
Sustained performance was reported by caregivers for those participants who
continued in an 16-month extension. Performance on the NPI was equivalent to
published findings at 3 to 6 months for donepezil and exceeded that of
galantamine and their historical placebos. Participants demonstrated
superior performance for more than 12 months in NPI and ADL versus those
receiving naproxen and rofecoxib or their placebo group. This formulation
holds promise for treatment of early-stage Alzheimer's disease prior to
and/or as a supplement for pharmacological approaches"
-
S-adenosylmethionine blood levels in major depression: changes with drug
treatment - Acta Neurol Scand Suppl. 1994;154:15-8
-
S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical
studies - Acta Neurol Scand Suppl. 1994;154:7-14
-
Oral S-adenosylmethionine in depression: a randomized, double-blind,
placebo-controlled trial - Am J Psychiatry. 1990 May;147(5):591-5
-
The antidepressant potential of oral S-adenosyl-l-methionine
- Acta Psychiatr Scand. 1990 May;81(5):432-6
Absorption Information:
-
Intestinal absorption of S-adenosyl-L-methionine -
J Pharmacol Exp Ther 1979 Jun;209(3):323-6
- SAM-e (S-Adenosylmethionine) - James South -
"Because SAMe tablets are enterically
coated, they should NOT be cut in half to achieve a lower dose- the SAMe may
then break down before absorption"
Note: There seems to be conflicting studies
on whether oral SAMe is poorly absorbed. Maybe the difference is "Enteric
coating" tablets.
Other possible
SAM-e suppliers:
Related Searches:
Recommended Reading:
70503
|
