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Anti-aging Research > Silymarin
Silymarin (Silybum
marianum)/Milk Thistle
Specific Recommendations:
News & Research:
-
Milk
thistle extract stops lung cancer in mice, study shows - Science Daily,
11/15/11 - "Compared to these multi-million dollar drugs, naturally-occurring silibinin blocked not only the expression of COX2 and iNOS, but also the
migration of existing lung cancer cells"
-
Milk
thistle herb protects cancer patients from chemotherapy-associated liver
toxicity - Science Daily, 12/27/09 - "Fifty
children with ALL were enrolled in the study and were randomized to receive
milk thistle or placebo for 28 days. At the start of the study, all of the
children had evidence of liver inflammation as measured by elevations in
blood levels of the liver enzymes, aspartate amino transferase (AST) and
amino alanine transferase (ALT). When the investigators performed liver
function tests on the children at day 56 (28 days after receiving the herb
or placebo), children receiving milk thistle had improvements in their liver
enzymes compared with children receiving a placebo. Specifically, the group
that took milk thistle had significantly lower levels of AST and a trend
towards significantly lower levels of ALT. Taking milk thistle also seemed
to help keep fewer patients from having to lower the dose of their
medications: chemotherapy doses were reduced in 61 percent of the group
receiving milk thistle, compared with 72 percent of the placebo group. In
addition, milk thistle appeared to be safe for consumption"
-
Herb May Treat Chemotherapy Liver Damage - WebMD, 12/14/09 -
"The youths who
took milk thistle had significantly lower levels of AST and a trend toward
significant lower levels of ALT, the researchers say ... Milk thistle also
seemed to help keep fewer patients from having to lower the dose of their
chemotherapy drugs ... Chemotherapy doses were reduced in 61% of those on milk
thistle, compared to 72% in the placebo group. Milk thistle appeared to be safe
for consumption, the researchers write"
-
Scientific Evidence Of The Significant Anti-cancer Effect Of Milk Thistle -
Science Daily, 11/14/07 - "Their research results
indicate that silibinin can be used to prevent the development of liver cancer,
one of the most common cancers worldwide"
-
Milk Thistle
Supplements review - ConsumerLab.com, 6/13/07 - "our
tests showed one supplement to have only 20% of the expected amount of silymarin
compounds — the key active components of milk thistle. Four other products
provided no more than two-thirds of their expected amounts. Another fell short
by 16%. And one supplement failed to identify the part of milk thistle used — a
FDA labeling requirement"
-
Milk Thistle May
Help Treat Diabetes - WebMD, 10/31/06 -
"At the study's start, the patients
had similar blood sugar levels and blood sugar control ... But after taking
the tablets for four months, the milk thistle group showed better blood
sugar control and cholesterol and triglyceride levels"
-
Milk thistle extract could help diabetes control - Nutra USA, 10/30/06 -
"fasting glucose levels of the
supplementation group decreased from 156 milligrams per decilitre (mg/dL) of
blood to 133 mg/dL, while the placebo group's fasting glucose levels
increased from 167 to 188 mg/dL" - See
iHerb
or
Vitacost
silymarin products.
-
Milk Thistle May
Slow Lung Cancer - WebMD, 6/20/06 -
"They found smaller lung tumors in
the mice with silibinin in their diets, compared with those consuming no
silibinin. They also had fewer large lung tumors"
-
Misinformed about Milk Thistle? - Dr. Weil, 5/1/06
-
Milk Thistle May
Not Cut Liver Disease - WebMD, 12/27/05
-
A New Weapon to Fight Prostate Cancer
- Life Extension Magazine, 11/05 - "Scientists have
shown that milk thistle extracts possess anti-cancer actions on human
prostate carcinoma in vitro and in vivo. Many of the mechanisms by which
silymarin compounds interfere with prostate cancer progression have been
identified. The scientists who conducted the most recent study stated that,
in addition to isosilybin B, there might be other silymarin compounds that
are effective as well"
-
Milk thistle "does not" lower mortality - Nutra USA, 5/3/05
-
Milk Thistle Supplements review - ConsumerLab.com, 10/28/04
-
Silibinin: The Herbal Extract that Protects the Liver - Life Extension
Magazine, 12/03 - "The extract from
the seeds of milk thistle contains
silibinin, a substance with
powerful liver-protection effects. In addition,
silibinin
can help reduce inflammation, diminish oxidation and free radical damage and
enhance health in other ways"
-
Can I take silymarin for my liver continuously, or do I need to take breaks
as with some other herbs? - drjanson.com, 3/03
- Silybin-Beta-Cyclodextrin Reduces Glucose, Triglyceride Levels In Diabetes
With Liver Disease - Doctor's Guide, 11/12/02 - "Fasting blood glucose levels decreased by 14.7 percent from baseline in
patients receiving
silybin-beta-cyclodextrin ...
Plasma triglycerides concentrations
dropped from a mean 186 to 111 mg/dl at six months in those that received
silybin-beta-cyclodextrin"
- See
iHerb
or
Vitacost
silymarin products.
- Pharmacology of Silymarin - Medscape, 1/02
-
Liver And Kidney Protection - Courtesy of Silibinin - Life Extension
Magazine, 6/00 - "We live in an age
of toxic overload. Silibinin, the chief active ingredient in milk thistle
extract, is one of our best defenses against this constant chemical assault.
Silibinin is highly effective at protecting the liver, the pancreas and the
kidneys from toxic damage, an ever-increasing danger due to our exposure to
harmful chemicals. In addition, silibinin has been shown to have various
other health benefits, including cancer prevention. The right dosage is
extremely important for effectiveness. People who complain that herb
products do not deliver as promised typically use products that contain only
ineffective, miniscule doses of the main active ingredient. Fortunately,
more and more herbal extracts, including silibinin, are now available in
guaranteed potency form, and in sufficient dosage to produce results."
-
Can Silibinin Arrest Cancer Cells Growth? - Life Extension Magazine,
6/00 - "It has been established that
silibinin is an effective scavenger of various free radicals, including
hydroxyl and peroxyl radicals, and the hypochlorite ion that originates in
neutrophils (Mira 1994). While it constitutes an important antibacterial
defense, the hypochlorite radical is also extremely damaging to normal
cells, and must be quickly "disarmed." Unchecked, the hypochlorite ion can
even chlorinate DNA bases. In the presence of iron, it creates the hydroxyl
radical, which can also directly attack DNA ... Silibinin has been found to
protect red blood vessels and stabilize their membranes through inhibition
of lipid peroxidation. In addition, silibinin increases the activity of the
antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase in
human red blood cells (Altorjay 1992). Another study found that silymarin
normalized low SOD activity and altered immunoreactivity in the lymphocytes
(a common type of white blood cell) of patients with alcoholic liver
cirrhosis"
- Milk
Thistle - Compiled by Chad Bradshaw, Pharm.D
-
The Prediabetic Epidemic - Nutrition Science News, 3/01 -
"Supplements to Regulate Glucose and Insulin ...
Alpha-Lipoic Acid ...
Vitamin E ... Vitamin
C ... Chromium ... Silymarin is an
antioxidant extract of the herb milk thistle (Silybum marianum). It has been
shown to reduce all of the major indicators of diabetes, including blood
sugar, insulin, glycosuria, and glycosylated hemoglobin. Researchers
achieved these results with 800 mg daily of a standardized silymarin extract
given for one year. The benefits appeared consistently after about 60 days,
and all diabetic signs improved further over the course of a year. However,
lower doses are probably sufficient in combination with other supplements
... Supplement tips: With other supplements, 200400 mg/day of a
standardized extract of silymarin should help maintain normal glucose
levels"
-
Milk Thistle's Liver-Protective Properties - Nutrition Science News,
10/99
- Milk Thistle Fruit - Nutrition Science News, 10/99
- Can Cirrhosis be Prevented? - Nutrition Science
News, 1/99
- Artichoke
Family Shows Promise in Preventing Skin Cancer -
Doctor's Guide, 4/27/97 - "Only 25% of the silymarin-treated mice developed tumors compared to 100% of
the control group mice"
Abstracts:
-
Silibinin prevents amyloid beta peptide-induced memory impairment and
oxidative stress in mice - Br J Pharmacol. 2009 Jun 22 -
"Silibinin (silybin), a flavonoid derived from the
herb milk thistle (Silybum marianum), has been shown to have antioxidative
properties; however, it remains unclear whether silibinin improves Abeta-induced
neurotoxicity ... Silibinin prevented the memory impairment induced by Abeta(25-35)
in the Y-maze and novel object recognition tests. Repeated treatment with
silibinin attenuated the Abeta(25-35)-induced accumulation of
malondialdehyde and depletion of glutathione in the hippocampus ...
Silibinin prevents memory impairment and oxidative damage induced by Abeta(25-35)
and may be a potential therapeutic agent for Alzheimer's disease"
-
The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty
Liver Disease: A Pilot Study - Dig Dis Sci. 2007 Apr 5 -
"silybin conjugated with vitamin E
and phospholipids could be used as a complementary approach to the treatment
of patients with chronic liver damage"
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