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Home > Health Conditions > Liver Disease
Liver Disease
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Oral
Tocotrienols Are Transported to Human Tissues and Delay the Progression of the
Model for End-Stage Liver Disease Score in Patients - J Nutr. 2012 Feb 1 -
"The natural vitamin E family is composed of 8 members
equally divided into 2 classes: tocopherols (TCP) and tocotrienols (TE). A
growing body of evidence suggests TE possess potent biological activity not
shared by TCP. The primary objective of this work was to determine the
concentrations of TE (200 mg mixed TE, b.i.d.) and TCP [200 mg α-TCP, b.i.d.)]
in vital tissues and organs of adult humans receiving oral supplementation ...
α-TE was delivered to human brain at a concentration reported to be
neuroprotective in experimental models of stroke. In prospective liver
transplantation patients, oral TE lowered the Model for end-stage liver disease
(MELD) score in 50% of patients supplemented, whereas only 20% of
TCP-supplemented patients demonstrated a reduction in MELD score. This work
provides, to our knowledge, the first evidence demonstrating that orally
supplemented TE are transported to vital organs of adult humans. The findings of
this study, in the context of the current literature, lay the foundation for
Phase II clinical trials testing the efficacy of TE against stroke and end-stage
liver disease in humans" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb
.
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Green Tea
Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced
Obese Rats with Nonalcoholic Steatohepatitis - J Nutr. 2011 Dec 7 -
"Nonalcoholic steatohepatitis (NASH) is characterized by
oxidative stress and inflammatory responses that exacerbate liver injury ...
Adult Wistar rats were fed a low-fat (LF) diet or high-fat (HF) diet containing
no GTE or GTE at 1% or 2% (HF+2GTE) for 8 wk. The HF group had greater (P ≤
0.05) serum alanine (ALT) and aspartate aminotransferases and hepatic lipids
than the LF group. Both GTE groups had lower ALT and hepatic lipid than the HF
group. In liver and epididymal adipose, the HF group had lower glutathione as
well as greater mRNA and protein expression of TNFα and monocyte chemoattractant
protein-1 (MCP-1) and NFκB binding activity than the LF group. Compared to the
HF group, the HF+2GTE group had greater glutathione and lower protein and mRNA
levels of inflammatory cytokines in both tissues. NFκB binding activities at
liver and adipose were also lower, likely by inhibiting the phosphorylation of
inhibitor of NFκB. NFκB binding activities in liver and adipose (P ≤ 0.05; r =
0.62 and 0.46, respectively) were correlated with ALT, and hepatic NFκB binding
activity was inversely related to liver glutathione (r = -0.35). These results
suggest that GTE-mediated improvements in glutathione status are associated with
the inhibition of hepatic and adipose inflammatory responses mediated by NFκB,
thereby protecting against NASH" - See
Jarrow Green Tea
extract at iHerb
.
-
α-Lipoic
acid prevents mild portal endotoxaemia-induced hepatic inflammation and β cell
dysfunction - Eur J Clin Invest. 2011 Nov 16 - "Male
Sprague-Dawley rats were randomly assigned into four groups: those with
intraportal vehicle (saline) or low-dose lipopolysaccharide (LPS) (0.42 ng/kg/min)
infusion, combined with oral administration of vehicle or LA, a potent
antioxidant (60 mg/kg/day) for 4 weeks ... The histopathological examination
showed that inflammatory changes were clearly visible in liver and pancreatic
islets of LPS-infused rats and rarely observed in those cotreated with LA. In
addition, low-dose intraportal LPS infusion also significantly impaired
glucose-stimulated insulin secretion but not affect the systemic insulin
sensitivity and metabolic clearance rate of insulin. LA administration markedly
reversed LPS-induced β cell dysfunction. Conclusions α-Lipoic acid cotreatment
could significantly prevent mild portal endotoxaemia-induced chronic hepatic
inflammation and impaired pancreatic insulin secretion in absence of changing
systemic insulin resistance" - See
alpha lipoic acid products at iHerb
.
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Effect of
folic acid intervention on ALT concentration in hypertensives without known
hepatic disease: a randomized, double-blind, controlled trial - Eur J Clin
Nutr. 2011 Nov 16 - "A total of 480 participants with
mild or moderate essential hypertension and without known hepatic disease were
randomly assigned to three treatment groups: (1) enalapril only (10 mg, control
group); (2) enalapril-FA tablet (10 mg enalapril combined with 0.4 mg of FA, low
FA group); and (3) enalapril-FA tablet (10 mg enalapril combined with 0.8 mg of
FA, high FA group), once daily for 8 weeks ... This report included 455
participants in the final analysis according to the principle of intention to
treat. We found a significant reduction in ALT level in the high FA group
(median (25th percentile, 75th percentile), -0.6 (-6.9, 2.0)IU/l, P=0.0008).
Compared with the control group, the high FA group showed a significantly
greater ALT-lowering response in men (median ALT ratio (ALT at week 8 to ALT at
baseline; 25th percentile, 75th percentile): 0.93 (0.67, 1.06) vs 1.00 (0.91,
1.21), P=0.032), and in participants with elevated ALT (ALT>40 IU/l) at
baseline. There was no difference in ALT lowering between the control and the
low FA group" - See
folic acid products at iHerb
.
-
Combination Antioxidant
Therapy May Help Fatty Liver - Medscape, 11/7/11 - "A combination of vitamin
E and alpha lipoic acid (ALA) can improve the inflammatory and steatosis scores
in patients with nonalcoholic fatty liver disease or nonalcoholic
steatohepatitis ... combination therapy resulted in a 70% difference in change
in tumor necrosis factors-alpha levels from baseline. ... ALA alone or vitamin E
alone were not as effective ... Nonalcoholic fatty liver disease is the most
common liver disease in the world ... In the United States, 20% of the general
population and 75% to 92% of the morbidly obese population suffer from the
disease" - See
Alpha lipoic acid products at iHerb
and
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb .
-
Protective
Effect of Lycopene against Radiation-induced Hepatic Toxicity in Rats - J
Int Med Res. 2011;39(4):1239-52 - "Lycopene supplementation significantly
reduced radiotherapy-induced oxidative liver injury" - See
lycopene products at iHerb.

-
Harvard study supports coffee’s anti-diabetes potential - Nutra USA, 9/21/11
- "Five cups of coffee per day for two months were associated with significant
metabolic benefits and live function ... the metabolic benefits were more
pronounced in caffeinated coffee, a result that supports the hypothesis that
caffeine is responsible for some of the apparent benefits ... Coffee is also a
rich source of polyphenols ... one cup of the stuff could provide 350 milligrams
of phenolics ... Of these, the most abundant compounds in coffee are chlorogenic
acids, making up to 12 per cent of the green coffee bean. The most abundant of
these compounds is caffeic acid ... recruited 45 healthy, overweight coffee
drinking 40 year olds ... volunteers were asked to drink five cups of coffee per
day of instant caffeinated coffee, decaffeinated coffee, or water for eight
weeks ... coffee consumption was associated with a 60% reduction in blood levels
of a compound called interleukin-6, which can promote inflammation, compared
with the water group ... In addition, levels of adiponectin – a hormone released
from fat cells that plays an important role in the regulation of insulin
sensitivity and energy – also decreased in the caffeinated, but not
decaffeinated group" - [Abstract]
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Creatine
Supplementation Prevents the Accumulation of Fat in the Livers of Rats Fed a
High-Fat Diet - J Nutr. 2011 Aug 31 - "In conclusion, creatine
supplementation prevented the fatty liver induced by feeding rats a HF diet,
probably by normalization of the expression of key genes of β-oxidation" - See
creatine products at iHerb.

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Resveratrol
attenuates steatosis in obese Zucker rats by decreasing fatty acid availability
and reducing oxidative stress - Br J Nutr. 2011 Jun 28:1-9 -
"Resveratrol
reduced liver weight and TAG content. It did not modify the activity of lipogenic enzymes but it did increase CPT-Ia and ACO activities. NEFA and ALP
were reduced in both resveratrol-treated groups. AST/GOT was reduced only by the
lowest dose. ALT/GPT, TAG and adiponectin remained unchanged. Resveratrol
reduced liver oxidative stress. This study demonstrates that resveratrol can
protect the liver from NAFLD by reducing fatty acid availability. Moreover,
resveratrol also protects liver from oxidative stress" - See
resveratrol products at iHerb.

-
Vitamin
E helps diminish a type of fatty liver disease in children, study suggests -
Science Daily, 4/27/11 - "Nonalcoholic fatty liver disease (NAFLD) is the most
common chronic liver disease among U.S. children. NAFLD ranges in severity from steatosis (fat in the liver without injury) to nonalcoholic steatohepatitis or
NASH (fat, inflammation, and liver damage). Fatty liver increases a child's risk
of developing heart disease and liver cirrhosis ... after 96 weeks of treatment,
58 percent of the children on vitamin E no longer had NASH, compared to 41
percent of the children on metformin (a diabetes drug), and 28 percent on
placebo. Vitamin E was better than placebo because it significantly reduced
enlargement and death of liver cells ... These results suggest that vitamin E
improves or resolves NASH in at least half of children, which we previously
showed to be true in adults" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.

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Limiting
carbs, not calories, reduces liver fat faster, researchers find - Science
Daily, 4/19/11 - "Curbing carbohydrates is more
effective than cutting calories for individuals who want to quickly reduce the
amount of fat in their liver ... could have implications for treating numerous
diseases including diabetes, insulin resistance and nonalcoholic fatty liver
disease, or NAFLD. The disease, characterized by high levels of triglycerides in
the liver, affects as many as one-third of American adults. It can lead to liver
inflammation, cirrhosis and liver cancer ... Weight loss, regardless of the
mechanism, is currently the most effective way to reduce liver fat"
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Protective
effect of whey proteins against nonalcoholic fatty liver in rats Lipids
Health Dis. 2011 Apr 13;10(1):57 - "Oral administration of the studied whey
proteins products reduced the final body weight of rats. There was a significant
reduction effect (P<0.05) of the tested proteins on hepatic triglycerides, liver
enzymes (ALT and AST), lipid peroxidation (malondialdehyde level) and serum
glucose. Feeding on whey proteins caused an increase in the reduced glutathione.
Hepatic content of reduced glutathione was not affected by any of the used whey
proteins, but it showed an increasing tendency (P>0.05). Liver histology showed
an improvement of fatty infiltration in hepatocytes from whey protein groups and
gives the histology of liver a normal appearance" - See
whey products at iHerb.

-
Aerobic
exercise may improve non-alcoholic fatty liver disease - Science Daily,
4/13/11 - "A study of 15 obese people with nonalcoholic
fatty liver disease revealed that the daily walks not only increase insulin
sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is
thought to be a marker of liver health ... The improvements are linked to an
increase in the hormone adiponectin ... Adiponectin influences the body's
response to insulin and is associated with a reduced risk of heart attack
because of its anti-inflammatory properties"
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Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats:
improvement by a combination of nutrients - Br J Nutr. 2011 Mar 22:1-8 -
"treatment with a combination of four nutrients, i.e.
R-α-lipoic acid, acetyl-l-carnitine, nicotinamide and biotin, just as with
pioglitazone, significantly improves glucose tolerance, insulin release, plasma
NEFA, skeletal muscle mitochondrial biogenesis and oxidative stress in
Goto-Kakizaki (GK) rats ... A 3-month treatment with the four nutrients
significantly improved most of these abnormalities in GK rats, and the effects
of the nutrient combination were greater than those of pioglitazone for most of
these indices. These results suggest that dietary supplementation with nutrients
that are thought to influence mitochondrial function may be an effective
strategy for improving liver dysfunction in GK diabetic rats"
-
Goto-Kakizaki rat:
Definition from Answers.com - "a strain of
laboratory rats that have an inherited predisposition to develop diabetes"
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Dietary Whey
Protein Lowers the Risk for Metabolic Disease in Mice Fed a High-Fat Diet -
J Nutr. 2011 Feb 10 - "whey protein isolate (WPI) ... Livers from WPI mice had
significantly fewer hepatic lipid droplet numbers and less deposition of nonpolar lipids. Furthermore, WPI improved glucose tolerance and insulin
sensitivity. We conclude that in mice receiving a HF diet, consumption of WPI
results in higher basal metabolic rates and altered metabolism of dietary
lipids. Because WPI mice had less hepatosteatosis and insulin resistance, WPI
dietary supplements may be effective in slowing the development of fatty liver
disease and type 2 diabetes" - See
whey products at iHerb.

-
Oral
acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a
randomized, double-blind, placebo-controlled study - Am J Clin Nutr. 2011
Feb 10 - "Fatigue is frequently reported in hepatic encephalopathy (HE) and may
be related to hyperammonemia. Acetyl-l-carnitine (ALC) offers neuroprotective
benefits and improves mitochondrial energetics and function ... At the end of
the study period, the ALC-treated patients in the HE1 group showed significantly
better improvement than did the placebo group in mental fatigue score (-1.7
compared with -0.3; P < 0.05), the fatigue severity scale (-6.4 compared with
2.3; P < 0.001), 7-d Physical Activity Recall questionnaire score (17.1 compared
with -2.5; P < 0.001), and Short Physical Performance Battery (2.1 compared with
0.2; P < 0.001); the HE2 group showed significantly better improvement in the
fatigue severity scale (-8.1 compared with -5.1; P < 0.001) and 6-min walk test
(19.9 compared with 2.3; P < 0.05). Significant decreases in NH(4)(+) were
observed in both groups (P < 0.001)" - See
acetyl-l-carnitine products at iHerb.

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Hepatic
encephalopathy - NIH - "Hepatic
encephalopathy is a worsening of brain function that occurs when the liver
is no longer able to remove toxic substances in the blood"
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Effects of a
whey protein supplementation on intrahepatocellular lipids in obese female
patients - Clin Nutr. 2011 Jan 31 - "intrahepatocellular
lipids (IHCL) ... 60 g/day whey protein supplement (WPS) for 4-weeks ... total
liver volume (MR) ... IHCL were positively correlated with visceral fat and
total liver volume at inclusion. WPS decreased significantly IHCL by 20.8 ±
7.7%, fasting total TG by 15 ± 6.9%, and total cholesterol by 7.3 ± 2.7%. WPS
slightly increased fat free mass from 54.8 ± 2.2 kg to 56.7 ± 2.5 kg, p =
0.005). Visceral fat, total liver volume, glucose tolerance, creatinine
clearance and insulin sensitivity were not changed" - See
whey products at iHerb.

-
Whey protein holds fat fighting potential, suggests study - Nutra USA,
2/3/11 - "The amount of fat inside liver cells (known as intra-hepatocellular
lipid concentrations – IHCL) in subjects fed a short term high fat diet has been
previously shown to be reduced again through increasing dietary protein intake
... four weeks of supplementation with whey protein led to a significant
decrease in IHCL of 21 percent, whilst fasting plasma triglyceride was observed
to decrease by 15 percent, and total plasma cholesterol concentration decreased
by over 7 percent" - [Abstract]
- See
whey products at iHerb.

-
Specific
populations of gut bacteria linked to fatty liver - Science Daily, 1/31/11 -
"A new research finding showing a strong relationship
between complex microbial ecologies in human intestines and the common but
serious medical condition known as fatty liver illustrates this paradox ...
Choline deficiency also implicates genetics, since many people lack the genes to
efficiently make choline internally ... The implication of the finding is that
these groups of bacteria may be influencing the body's ability to properly use
the choline available in food ... bioinformatics researchers at the University
of North Carolina at Charlotte found a strong correlation between the relative
abundances of two specific classes of bacteria and the development of fatty
liver ... Those patients with the highest abundance of Gammaproteobacteria at
the beginning of the study seemed to have the lowest fatty liver development.
The ones with the least developed the most fatty liver ... Erysipeoltrichi
showed exactly the opposite association, though this relationship was not quite
as strong. So there seemed to be change going on in opposite directions"
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Preventive
Effects of Taurine on Development of Hepatic Steatosis Induced by a
High-Fat/Cholesterol Dietary Habit - J Agric Food Chem. 2010 Dec 2 -
"Nonalcoholic fatty liver (NAFL) is also called hepatic steatosis and has become
an emergent liver disease in developed and developing nations ... taurine (Tau)
... Tau shows preventive effects on the development of hepatic steatosis induced
by a high-fat/cholesterol dietary habit" - See
taurine products at iHerb.

-
Spice in
curry could prevent liver damage - Science Daily, 10/29/10 -
"Curcumin, a
chemical that gives curry its zing, holds promise in preventing or treating
liver damage from an advanced form of a condition known as fatty liver disease
... non-alcoholic steatohepatitis (NASH). Linked to obesity and weight gain,
NASH affects 3 to 4 percent of U.S. adults and can lead to a type of liver
damage called liver fibrosis and possibly cirrhosis, liver cancer and death ...
High levels of leptin activate hepatic stellate cells, which are the cells that
cause overproduction of the collagen protein, a major feature of liver fibrosis.
The researchers found that among other activities, curcumin eliminated the
effects of leptin on activating hepatic stellate cells, which short-circuited
the development of liver damage" - See
curcumin/turmeric products at iHerb.

-
Olive
oil protects liver from oxidative stress, rat study finds - Science Daily,
10/29/10 - "researchers separated the rats into a control group, an olive oil
group, and 6 groups that were exposed to the herbicide
'2,4-Dichlorophenoxyacetic acid' with or without either whole olive oil, or one
of two oil extracts -- the hydrophilic fraction or the lipophilic fraction. All
rats given the herbicide showed signs of significant liver damage. However,
extra virgin olive oil and hydrophilic fraction intake induced a significant
increase in antioxidant enzyme activity and a decrease in markers of liver
damage ... The hydrophilic fraction of olive oil seems to be the effective one
in reducing toxin-induced oxidative stress, indicating that hydrophilic extract
may exert a direct antioxidant effect on hepatic cells" - See
olive leaf extracts at iHerb.

-
Exercise
counteracts fatty liver disease in rats fed on fructose-rich diet -
Lipids Health Dis. 2010 Oct 14;9(1):116 - "The
fructose-fed rats showed decreased insulin sensitivity, and the
late-exercise training protocol counteracted this alteration. There was no
difference between the groups in levels of serum ALT, whereas AST and liver
lipids increased in the fructose-fed sedentary group when compared with the
other groups. Serum triglycerides concentrations were higher in the
fructose-fed trained groups when compared with the corresponding control
group"
-
Oral vitamin
D replacement is effective in chronic liver disease Gastroenterol Clin Biol.
2010 Aug 27 - "25[OH]D was suboptimal in 101/158 (64%), including severe
deficiency in 24 patients (15%). Vitamin D deficiency occurred in liver disease
of all aetiologies, including patients with only mild liver disease. 25[OH]D
increased by 60.0% (19.11+/-13.20nmol/l) in patients with deficiency after
vitamin D replacement and decreased by 25.2% (-18.33+/-12.02nmol/l) in
non-treated initially replete patients over a median of 4 months ...
CONCLUSIONS: Vitamin D deficiency improves with oral vitamin D supplementation
and levels fall without supplementation. Chronic liver disease patients are at
very high risk of vitamin D deficiency regardless of etiology or severity" - See
vitamin D products at iHerb.

-
Coffee
and the liver: a potential treatment for liver disease? - Eur J
Gastroenterol Hepatol. 2010 Aug 26 - "Several
studies consistently show that coffee drinkers have a reduced risk of
abnormal liver function tests, cirrhosis and hepatocellular carcinoma. There
is a clear dose response to this benefit"
-
Intake of
n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a
cross-sectional study in Japanese men and women - Eur J Clin Nutr. 2010 Aug
4 - "The prevalence of NAFLD was 45.3% in men and 17.5% in women. In comparison
with the first tertile, multivariate adjusted odds ratios (95% confidence
intervals) for the presence of NAFLD in the second and third tertiles for men
taking eicosapentaenoic acid (EPA) were 0.59 (0.31-1.14) and 0.45 (0.23-0.90),
respectively, (P for linear trend=0.024), and the multivariate adjusted odds
ratios (95% confidence intervals) for the presence of NAFLD in the second and
third tertiles for men taking EPA+docosahexaenoic acid (DHA) were 0.44
(0.23-0.86) and 0.48 (0.24-0.95), respectively, (P for linear trend=0.035).
However, there was no significant relation between NAFLD and each of these
nutrients in women.Conclusions:Dietary EPA and EPA+DHA may be independent and
preventive nutrients for NAFLD in Japanese men" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb.
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Finally, Vitamin E May Work -- And It's in the Liver - Medscape, 7/6/10 -
"We used to call this "fatty liver"; now it's got a fancier name -- it's
"nonalcoholic steatohepatitis." ... It turned out that only the Vitamin E group
managed to reach that level of significance" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at iHerb.

-
High
fructose, trans fats lead to significant liver disease, says study -
Science Daily, 6/22/10 - "mice fed the normal
calorie chow diet remained lean and did not have fatty liver disease. Mice
fed high calorie diets (trans-fat alone or a combination of trans-fat and
high fructose) became obese and had fatty liver disease ... it was only the
group fed the combination of trans-fat and high fructose which developed the
advanced fatty liver disease which had fibrosis ... This same group also had
increased oxidative stress in the liver, increased inflammatory cells, and
increased levels of plasma oxidative stress markers"
-
Blueberry ameliorates hepatic fibrosis, study finds - Science Daily, 6/17/10
- "An increasing number of natural substances have been studied to explore if
they have protective effects on the liver. Blueberries have unique effects on
human retinal, brain and tumor cells, but reports about the effects of
blueberries on liver diseases are lacking ... The authors suggest that blueberry
consumption is beneficial for hepatic diseases (including fibrosis)" - See
blueberry extracts at iHerb.

-
Chromium
attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice
- Biochem Biophys Res Commun. 2010 May 27 - "Chromium supplementation prevented
progression of NAFLD and the beneficial effects were accompanied by reduction of
hepatic triglyceride accumulation, elevation of hepatic lipid catabolic enzyme,
improvement of glucose and lipid metabolism, suppression of inflammation as well
as resolution of oxidative stress, probably through enhancement of insulin
signaling. Our findings suggest that chromium could serve as a hepatoprotective
agent against NAFLD" - See
ChromeMate® products at iHerb.

-
Effects
of a 1-year dietary intervention with n-3 polyunsaturated fatty
acid-enriched olive oil on non-alcoholic fatty liver disease patients: a
preliminary study - Int J Food Sci Nutr. 2010 May 13 -
"Consumption of olive oil enriched with n-3 PUFA
demonstrated a significant improvement of liver echo-texture and of the
Doppler Perfusion Index after 12 months (after: 0.19 +/- 0.02 vs. pre: 0.15
+/- 0.03; P < 0.05), whereas no significant changes were seen at the end of
follow-up in controls. Moreover, patients who consumed the olive oil
enriched with n-3 PUFA showed a significant amelioration of liver enzymes,
and of triglycerides (post: 132.8 +/- 63.7 vs. pre: 164.5 +/- 85.5 mg/dl; P
= 0.04) in a general linear model adjusted for age and gender.
Interestingly, patients reported to have a significant increase of
adiponectin levels (post: 1,487.9 +/- 96.7 vs. pre: 1,143 +/- 24.8 mug/ml; P
= 0.04)"
-
Vitamin E may be new boon for liver disease - MSNBC, 4/28/10 -
"In the study
published online in the New England Journal of Medicine, 247 adults with
advanced fatty liver disease were randomly assigned to take a high dose of
vitamin E (800 international units), the diabetes drug Actos or dummy pills for
nearly two years ... Biopsies before and after treatment showed that liver
function improved in 43 percent of those in the vitamin E group compared with 19
percent in the placebo group ... participants on the diabetes drug Actos also
improved, but to a lesser degree and with a drawback: gaining 10 pounds on
average, which remained even after they stopped taking the drug" - See
Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb
.
-
Indian
spice may delay liver damage and cirrhosis, study suggests - Science Daily,
3/24/10 - "The findings showed that the curcumin diet
significantly reduced bile duct blockage and curbed liver cell (hepatocyte)
damage and scarring (fibrosis) by interfering with several chemical signalling
pathways involved in the inflammatory process" - See
curcumin/turmeric products at iHerb.

-
High
fructose corn syrup linked to liver scarring, research suggests -
Science Daily, 3/22/10 - "The researchers found only
19 percent of adults with NAFLD reported no intake of fructose-containing
beverages, while 52 percent consumed between one and six servings a week and
29 percent consumed fructose-containing beverages on a daily basis"
-
Pomegranate oil-seaweed mix may improve liver health and waist size -
Nutra USA, 1/25/10 - "Results showed that body weight was significantly
reduced by an average of 5.5 kg in people in the NAFLD group and 4.9 kg in
the normal liver function group. Women in the placebo group lost an average
of 1.4 kilos. In addition, women with NAFLD experienced improvements in
waist circumference, body and liver fat content, liver enzymes, and serum
triglycerides" - [Abstract]
- 5.5 kg is 12.1 pounds - See
Garden of Life, FucoThin, Natural Fat Burner, 180 Softgels (200 mg of Xanthigen Proprietary Blend)
at iHerb.
-
The
effects of Xanthigen in the weight management of obese premenopausal women with
non-alcoholic fatty liver disease and normal liver fat - Diabetes Obes Metab.
2010 Jan;12(1):72-81 - "Xanthigen-600/2.4 mg (300 mg PSO + 300 mg brown seaweed
extract containing 2.4 mg fucoxanthin) resulted in statistically significant
reduction of body weight (5.5 +/- 1.4 kg NAFLD group and 4.9 +/- 1.2 kg NLF
group, p < 0.05), waist circumference (NAFLD group only), body (3.5 +/- 1.9 kg
NAFLD group, p < 0.001; 3.6 +/- 0.7 kg NLF group, p < 0.05) and liver fat
content, liver enzymes (NAFLD group only), serum triglycerides and C-reactive
protein. Weight loss and reduction in body and liver fat content occurred
earlier in patients with NLF than in patients with NAFLD. Fucoxanthin (> 2.4 mg)
and Xanthigen-400/1.6 mg (200 mg PSO + 200 mg brown seaweed extract containing
1.6 mg fucoxanthin) significantly increased REE in NAFLD subjects compared to
placebo. CONCLUSIONS: Xanthigen promoted weight loss, reduced body and liver fat
content, and improved liver function tests in obese non-diabetic women.
Xanthigen and Fucoxanthin also increased REE. This product may be considered a
promising food supplement in the management of obesity" - See
Garden of Life, FucoThin, Natural Fat Burner, 180 Softgels (200 mg of Xanthigen Proprietary Blend)
at iHerb.
-
Review
article: omega-3 fatty acids - a promising novel therapy for non-alcoholic
fatty liver disease - Aliment Pharmacol Ther. 2009 Dec 30 -
"Non-alcoholic fatty liver disease (NAFLD) affects
10-35% of the adult population worldwide; there is no consensus on its
treatment ... Omega-3 fatty acids are important regulators of hepatic gene
transcription. Animal studies demonstrate they reduce hepatic steatosis,
improve insulin sensitivity and reduce markers of inflammation. Clinical
trials in human subjects generally confirm these findings but have
significant design inadequacies. Conclusions Omega-3 fatty acids are a
promising treatment for NAFLD which require to be tested in randomised
placebo controlled trials" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Review supports omega-3 for liver health - Nutra USA, 1/6/10 -
"A review of four human studies found that the fatty
acids could improve liver health and function, and increase insulin
sensitivity in people suffering from fatty liver, a condition that is
usually symptomless but said to increase the risk for liver inflammation,
and ultimately results in liver failure" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Milk
thistle herb protects cancer patients from chemotherapy-associated liver
toxicity - Science Daily, 12/27/09 - "Fifty
children with ALL were enrolled in the study and were randomized to receive
milk thistle or placebo for 28 days. At the start of the study, all of the
children had evidence of liver inflammation as measured by elevations in
blood levels of the liver enzymes, aspartate amino transferase (AST) and
amino alanine transferase (ALT). When the investigators performed liver
function tests on the children at day 56 (28 days after receiving the herb
or placebo), children receiving milk thistle had improvements in their liver
enzymes compared with children receiving a placebo. Specifically, the group
that took milk thistle had significantly lower levels of AST and a trend
towards significantly lower levels of ALT. Taking milk thistle also seemed
to help keep fewer patients from having to lower the dose of their
medications: chemotherapy doses were reduced in 61 percent of the group
receiving milk thistle, compared with 72 percent of the placebo group. In
addition, milk thistle appeared to be safe for consumption" - See
silymarin (milk thistle) products at iHerb
.
-
Herb May Treat Chemotherapy Liver Damage - WebMD, 12/14/09 -
"The youths who
took milk thistle had significantly lower levels of AST and a trend toward
significant lower levels of ALT, the researchers say ... Milk thistle also
seemed to help keep fewer patients from having to lower the dose of their
chemotherapy drugs ... Chemotherapy doses were reduced in 61% of those on milk
thistle, compared to 72% in the placebo group. Milk thistle appeared to be safe
for consumption, the researchers write" - See
silymarin (milk thistle) products at iHerb
.
-
Antifibrotic effects of green tea - Science Daily, 11/18/09 -
"The researchers drew a conclusion that green tea
may protect liver cells and reduce the deposition of collagen fibers in the
liver. Green tea provides a safe and effective strategy for improving
hepatic fibrosis" - See
Jarrow green tea extract at iHerb
.
-
Medication Effective For Acute Liver Failure In Early Stages Of Disease, Study
Suggests - Science Daily, 10/8/09 - "Researchers found that 52 percent of
acute liver failure patients in mild to moderate comas survived when treated
with NAC, compared to just 30 percent of those treated with only a placebo. In
patients experiencing more severe coma, treatment with NAC did not result in a
significant difference in survival rates" - See
NAC products at iHerb.

-
Regular Aerobic Exercise Reduces Health Concerns Associated With Fatty Liver
- Science Daily, 9/9/09
-
Liver
Carbohydrate and Lipid Metabolism of Insulin-Deficient Mice Is Altered by
trans-10, cis-12 Conjugated Linoleic Acid - J Nutr. 2009 Aug 19 -
"Feeding mice the trans-10, cis-12 (t10c12)
conjugated linoleic acid (CLA) isomer is associated with lipodystrophy,
insulin resistance, hyperinsulinemia, and liver steatosis. It has been
hypothesized that CLA-induced liver steatosis is the result of increased
hepatic lipogenesis stimulated by high insulin levels. We studied the
effects of a 12-d t10c12CLA treatment (1 g/100 g diet) on liver carbohydrate
and lipid metabolism in control and streptozotocin (STZ)-injected mice. STZ
mice were characterized by insulin deficiency, hypertriglyceridemia, and
depletion of liver triglyceride and glycogen. Remarkably, feeding t10c12CLA
to diabetic mice (STZ-CLA) normalized these variables. Reconstitution of fat
stores in the livers of STZ-CLA mice was associated with lower fatty acid
(FA) oxidation rates and greater malonyl-CoA concentration than in STZ mice.
FA translocase and VLDL receptor mRNA levels were greater in STZ-CLA than in
STZ mice, suggesting that t10c12CLA increased liver lipid uptake.
Phosphoenolpyruvate carboxykinase mRNA levels and AMP kinase phosphorylation
were lower in STZ-CLA than in STZ mice, indicating that t10c12CLA may reduce
glucogenic activity and promote glycogenesis in diabetic mice. Because
glycemia and glucokinase expression were not modified by t10c12CLA
treatment, we postulated that glycogen accumulation is likely not the result
of an effect of t10c12CLA on plasma glucose utilization, but rather is due
to the contribution of lactate, the concentration of which was higher in
muscle of STZ-CLA mice. The results demonstrate that t10c12CLA stimulates
liver lipid accumulation in the absence of insulin and, thus, suggest that
t10c12CLA can improve liver carbohydrate and lipid metabolism in type I
diabetic mice" - See
CLA products at iHerb
.
-
Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary
Liver Cancer In Rats - Science Daily, 7/30/09 -
"A new study investigated the effectiveness of S-adenosylmethionine (SAMe)
in the prevention and treatment of hepatocellular carcinoma (HCC) or primary
liver cancer. SAMe, a widely available nutritional supplement, with little
known side effects, was found to be effective in preventing the formation of
HCC in rats" - [Abstract]
- See
SAM-e products at iHerb
.
-
S-adenosylmethionine
in the chemoprevention and treatment of hepatocellular carcinoma in a rat
model - Hepatology. 2009 Apr 6 - "SAMe is
effective in preventing HCC establishment but ineffective in treating
established HCC because of induction of hepatic methyltransferases, which
prevents SAMe level to reach high enough to kill liver cancer cells. SAMe's
chemopreventive effect may be related to its proapoptotic action and its
ability to inhibit angiogenes" - See
SAM-e products at iHerb
.
-
Curcumin
suppresses expression of low-density lipoprotein (LDL) receptor, leading to
the inhibition of LDL-induced activation of hepatic stellate cells - Br
J Pharmacol. 2009 Jul 7 - "This curcumin, a
constituent of turmeric, may be useful in preventing
hypercholesterolemia-associated hepatic fibrogenesis" - See
curcumin/turmeric products at iHerb
.
-
Fish
Oil-Based Lipid Emulsions Prevent and Reverse Parenteral
Nutrition-Associated Liver Disease: The Boston Experience - JPEN J
Parenter Enteral Nutr. 2009 Jul 1 - "Parenteral
nutrition-associated liver disease (PNALD) is the most prevalent and most
severe complication of long-term parenteral nutrition. Its underlying
pathophysiology, however, largely remains to be elucidated. The currently
approved parenteral lipid emulsions in the United States contain safflower
or soybean oils, both rich in omega-6 polyunsaturated fatty acids (PUFAs).
Mounting evidence indicates that the omega-6 PUFAs originating from plant
oils in these lipid emulsions may play a role in the onset of liver injury.
Fish oil-based lipid emulsions, in contrast, are primarily composed of
omega-3 PUFAs, thus providing a promising alternative. The authors review
the literature on the role of lipid emulsions in the onset of PNALD and
discuss prevention and treatment strategies using a fish oil- based lipid
emulsion. They conclude that a fish oil-based emulsion is hepatoprotective
in a murine model of PNALD, and it appears to be safe and efficacious for
the treatment of this type of liver disease in children" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver
cells - Eur J Clin Invest. 2009 Jun 8 - "In
hepatocytes from normal rats, the quercetin-induced decrease in both de novo
fatty acid and TAG synthesis, with a consequent reduction in VLDL-TAG
formation, may represent a potential mechanism contributing to the reported
hypotriacylglycerolemic effect of quercetin" - See
quercetin products at iHerb
.
-
Combination of vitamin K(2) and angiotensin-converting enzyme inhibitor
ameliorates cumulative recurrence of hepatocellular carcinoma - J
Hepatol. 2009 May 15 - "A 48-month follow-up
revealed that the combination treatment with VK and ACE-I markedly inhibited
the cumulative recurrence of HCC in association with suppression of the
serum level of the vascular endothelial growth factor (VEGF); a central
angiogenic factor. The serum level of lectin-reactive alpha-fetoprotein was
also suppressed almost in parallel with VEGF. These beneficial effects were
not observed with single treatment using VK or ACE-I" - See
vitamin K products at iHerb
.
-
Two
Glasses Of Wine A Day Helps To Reduce Quantity Of Fat In Liver - Science
Daily, 5/12/09 - "Alter four weeks, samples of liver
and blood were taken from individuals of the three different groups for
their subsequent analysis. It was shown that in the third group - the one
treated with resveratrol -, infiltration of liver fat dropped in comparison
with group two. After this and a number of other analyses, the researcher
concluded that resveratrol reduces the severity of ESNA in models with rats
because, in the animals treated with resveratrol, the percentage of the
cells of affected liver cells was notably less in non-treated animals"
- See
Jarrow Resveratrol 100 at iHerb
.
-
Fatty Liver Disease: The Next Big Thing - Science Daily, 4/19/09 -
"New research in The Journal of Physiology connects
low aerobic capacity to another serious condition – non-alcoholic fatty
liver disease (NAFLD) – and suggests that the resulting liver problems play
a crucial step developing obesity-related illnesses ... Sufferers of NAFLD
accumulate fat in their livers and have high levels of fat in their blood,
amplifying the risk-factors of obesity. The disease leads to a form of liver
damage called fibrosis, similar to the results of alcohol abuse"
-
Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via
Sirt1-FOXO1 signaling pathway - Biochem Biophys Res Commun. 2009 Mar
13;380(3):644-9 - "Our results suggest that
resveratrol may attenuate fat deposition by inhibiting SREBP1 expression via
Sirt1-FOXO1 pathway and thus may have application for the treatment of
NAFLD" - See
Jarrow Resveratrol 100 at iHerb
.
-
Why
Diets High In High-fructose Corn Syrup (found In Soda And Processed Foods)
Can Lead To Insulin Resistance - Science Daily, 3/3/09 -
"mice on a high-fructose diet were protected from
insulin resistance when a gene known as transcriptional coactivator PPARg
coactivator-1b (PGC-1b) was "knocked down" in the animals' liver and fat
tissue ... Fructose is much more readily metabolized to fat in the liver
than glucose is and in the process can lead to nonalcoholic fatty liver
disease ... NAFLD in turn leads to hepatic insulin resistance and type II
diabetes"
-
Fat-free Diet Reduces Liver Fat In Fat-free Mice, Researchers Report -
Science Daily, 2/13/09
-
Omega-3 Fatty Acids Prevent Medical Complications Of Obesity, Study Suggests
- Science Daily, 2/12/09 - "Our study shows for the
first time that lipids called protectins and resolvins derived from omega-3
fatty acids can actually reduce the instance of liver complications, such as
hepatic steatosis and insulin resistance, in obese people"
- See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Aspirin May Prevent Liver Damage That Afflicts Millions, Study Finds -
Science Daily, 1/26/09 - "Simple aspirin may prevent
liver damage in millions of people suffering from side effects of common
drugs, alcohol abuse, and obesity-related liver disease"
-
New
Therapeutic Properties Of N-acetyl-L-cysteine Discovered - Science
Daily, 1/19/09 - "N-acetyl-L-cysteine (NAC) combined
with mesalamine produces a significant improvement in patients suffering
from ulcerative colitis ... N-acetyl-L-cysteine, is a drug normally used for
the treatment of chronic obstructive pulmonary disease (COPD) and to
minimize the effects of cold and flu. Its hepatic protective properties also
make this drug a useful tool in paracetamol intoxications ...
N-acetyl-L-cysteine reduced the negative effects caused by azathioprine, a
immunosuppressant of clinical use, on the liver" - See
NAC products at iHerb
.
-
How Did
Glycine Significantly Decrease Liver Injury? - Science Daily, 10/31/08 -
"Recent studies demonstrated that dietary glycine
protected both the lung and liver against lethal doses of endotoxin in rat or
other animals and improved graft survival after liver transplantation" -
See
L-glycine products at iHerb
.
-
Bilberry extract may ease the damages of stress: study - Nutra USA,
10/28/08 - "Mice supplemented with an anthocyanin-rich
bilberry extract (Mirtoselect, Indena) at doses of 50, 100, and 200
milligrams per kilograms per day experienced lower ALT levels than
non-supplemented restrained animals (17.23 versus 107.68 units per litre,
respectively)"
-
Low-carb
Diets Alter Glucose Formation By The Liver - Science Daily, 10/20/08 -
"a low-carbohydrate diet changes hepatic energy
metabolism. When carbohydrates are restricted, the liver relies more on
substances like lactate and amino acids to form glucose, instead of glycerol
... They suggest that the shift in glucose metabolism associated with a low
carbohydrate diet could be beneficial in individuals with non-alcoholic
fatty liver disease (NAFLD) due to improved disposal of hepatic fat"
-
Resveratrol Prevents Fat Accumulation In Livers Of 'Alcoholic' Mice
- Science Daily, 10/14/08 - "The
accumulation of fat in the liver as a result of chronic alcohol
consumption could be prevented by consuming resveratrol, according
to a new study with mice. The research found that resveratrol
reduced the amount of fat produced in the liver of mice fed alcohol
and, at the same time, increased the rate at which fat within the
liver is broken down" - [WebMD] - See
Jarrow Resveratrol 100 at iHerb
.
-
Vitamin D Deficiency Common In Patients With IBD, Chronic Liver Disease
- Science Daily, 10/13/08 - "analyzed
vitamin D
levels of 504
inflammatory bowel disease patients ...
almost 50 percent of the patients were Vitamin D deficient at some point,
with 11 percent being severely deficient ... 92.4 percent of chronic liver
patients had some degree of vitamin D deficiency and at least one third were
severely deficient. Severe vitamin D deficiency was more common among
cirrhotics" -
See
vitamin D products at iHerb
.
-
Patients With IBD, Chronic Liver Disease at Increased Risk of Vitamin D
Deficiencies - Doctor's Guide, 10/7/08 -
"conducted analysed vitamin D levels of 504 patients with IBD ...
researchers found almost 50% of the patients were vitamin D deficient at
some point, with 11% being severely deficient ... with hepatitis C virus
(HCV) ... 92.4% of the patients had some degree of vitamin D deficiency and
at least one-third was severely deficient" - See
vitamin D products at iHerb
.
-
Can
Taurine Be A Potent Antioxidant Drug In The Future? - Science Daily,
9/19/08 - "Taurine is a potent antioxidant with
hepatoprotective effects. Organelle based changes in hepatocytes after
taurine treatment in experimental liver fibrosis were searched
systematically and organelle injury scores decreased were found to decrease
significantly" - See
taurine products at iHerb
.
-
Protective Effects of
Bilberry (Vaccinium myrtillus L.) Extract on Restraint Stress-Induced Liver
Damage in Mice - J Agric Food Chem. 2008 Aug 9 -
"Bilberry extract (containing 42.04% anthocyanins) was oral administrated to
mice at 50, 100, and 200 mg/(kg.day) for five days, which remarkably
decreased plasma ALT level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg.day)
and thus alleviated stress-induced liver damage. In addition, bilberry
extracts increased glutathione (GSH) and vitamin C levels and significantly
decreased MDA and nitric oxide (NO) levels in the liver tissues. These
results suggest that bilberry extract plays an important role in protecting
against restraint stress-induced liver damage by both scavenging free
radicals activity and lipid peroxidation inhibitory effect. This study
showed the beneficial health effects of bilberry extract through its
antioxidative action" - See
bilberry products at iHerb
.
-
Red wine keeps liver healthy, suggests new study - Nutra USA, 5/22/08 -
"People who drank up to one glass of wine a day saw
the risk of liver disease due to Non-Alcoholic Fatty Liver Disease (NAFLD)
cut in half ... In contrast, compared with wine drinkers, people who
reported modest consumption of beer or spirits had over four times the odds
of having suspected NAFLD"
-
Fast-Food Liver Damage Can Be Reversed, Experts Say - Science Daily,
4/30/08 - "Diets high in fast food can be highly
toxic to the liver and other internal organs, but that damage can be
reversed ... You can likely reverse the damage to your liver and other vital
organs if you simply give up the unhealthy lifestyle"
-
Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated
postmenopausal breast cancer women with special reference to blood chemistry
profiles - Breast Cancer Res Treat. 2008 Apr 22 -
"Tamoxifen (TAM) ... TAM also has estrogenic
activity on liver and endometrium causing severe oxidative stress with
various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN)
are well-known potent antioxidants and protective agents against many
diseases including cancer ... A statistically significant alteration in
various blood chemistry parameters, such as serum total bilirubin (S. BIL),
serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate
transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid
(UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases
(LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group,
was favorably reverted back to near normal levels on combinatorial therapy
with CoRN" - See
coenzyme Q10 products at iHerb
.
-
Hepatoprotective effect of vitamin b(12) on dimethylnitrosamine-induced
liver injury - Biol Pharm Bull. 2008 Feb;31(2):309-11 -
"Vitamin B(12) decreased the blood levels of
aspartate aminotransferase and alanine aminotransferase, and clearly
inhibited the overaccumulation of collagen fibrils ... vitamin B(12) could
be an effective hepatoprotective agent" - Note: Aspartate
aminotransferase is the AST reading on blood tests and alanine
aminotransferase is the ALT. See
iHerb
vitamin B12 products.
-
Green Tea Extract Protects Leptin-Deficient, Spontaneously Obese Mice from
Hepatic Steatosis and Injury - J Nutr. 2008 Feb;138(2):323-331 -
"Histologic evaluation showed a significant
reduction in hepatic steatosis in GTE-fed obese mice only and histologic
scores were correlated with hepatic lipid concentration (r = 0.84; P <
0.05), which was reduced dose dependently by GTE. GTE protected against
hepatic injury as suggested by 30-41% and 22-33% lower serum alanine
aminotransferase and aspartate aminotransferase activities, respectively"
- Note: Alanine aminotransferase is the "ALT" you see on blood tests
and aspartate aminotransferase is the "AST" you see on blood tests.
See
Jarrow green tea at iHerb
.
-
Green tea shows benefits against fatty liver - Nutra USA, 1/22/08 -
"the obese mice fed the GTE-supplemented diets had
23 to 25 per cent less body than the obese mice fed the non-supplemented
diet. Moreover, the lean mice fed the GTE-supplemented diets had 11 to 20
per cent less body than their lean counterpart on the non-supplemented diet
... Measurements of the blood enzymes alanine aminotransferase and aspartate
aminotransferase, used as markers of liver damage, showed that
GTE-supplementation was associated with 30 to 41 per cent and 22 to 33 per
cent lower activities, respectively" - [Abstract]
- Note: Alanine aminotransferase is the "ALT" you see on blood tests
and aspartate aminotransferase is the "AST" you see on blood tests.
See
Jarrow green tea at iHerb
.
-
Treatment With NAC Is Associated With Better Outcomes For Children With
Liver Failure, Study Suggests - Science Daily, 1/3/08 -
"The children who received NAC spent fewer days in
intensive care, and in the hospital overall. 43 percent survived with their
native liver, compared to 22 percent of children who did not receive NAC.
And death rates while awaiting transplant, after transplant, and after ten
years were notably lower in children who had received NAC" - See
NAC products at iHerb
.
-
Dietary lipoic acid-dependent changes in the activity and mRNA levels of
hepatic lipogenic enzymes in rats - Br J Nutr. 2007 Dec 7;:1-9 -
"Lipoic acid profoundly decreased serum and liver
concentrations of TAG, and also lowered serum concentrations of phospholipid
and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic
effect of this compound was also observed. Lipoic acid dose-dependently
decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate
lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase
in the liver despite that reductions were considerably attenuated in the
NADPH-producing enzymes. This compound also dose-dependently lowered the
mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5-
and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered
serum concentrations of insulin and leptin, but increased those of
adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence
decreases serum and liver lipid levels. Alterations in serum concentrations
of insulin and (or) adiponectin may trigger this consequence" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
at iHerb
.
-
Quick-burning Carbs May Cause Fatty Liver: Low-glycemic Diet Protected Mice
- Science Daily, 9/21/07 - "After six months, the
mice weighed the same. However, mice on the low-glycemic index diet were
lean, with normal amounts of fat in throughout their bodies. Mice on the
high-glycemic index diet had twice the normal amount of fat in their bodies,
blood and livers"
-
Starchy diet 'may damage liver' - BBC News, 9/21/07 -
""High-glycaemic" foods - rapidly digested by the
body - could be causing "fatty liver", increasing the risk of serious
illness ... After six months on the diet, the mice weighed the same, but
those on the high GI diet had twice the normal amount of fat in their
bodies, blood and livers"
-
The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty
Liver Disease: A Pilot Study - Dig Dis Sci. 2007 Apr 5 -
"silybin
conjugated with vitamin E and
phospholipids could be used as a complementary
approach to the treatment of patients with chronic liver damage"
-
Zinc and the Liver: An Active Interaction - Dig Dis Sci. 2007 Apr 6 -
"zinc could protect against liver
diseases"
-
Sugar intake may hurt liver - Reuters, 10/31/06 -
"fatty liver disease was more common in
the group given sugar water, especially when exposed to a type of sugar called
fructose ... These data support the hypothesis that high fructose consumption
may not only (damage) the liver through over-feeding, but may be directly"
toxic"
-
Obesity and Fatty Liver disease - MedicineNet.com -
"Doctors also are using
medications to treat non alcoholic fatty liver disease. For example,
insulin-sensitizing agents, such as the thiazolidinediones,
pioglitazone (Actos)
and rosiglitazone
(Avandia), and metformin (Glucophage) not
only help to control blood glucose in patients with diabetes, but they
also improve enzyme levels in patients with non alcoholic fatty liver
disease" - See pioglitazone or rosiglitazone at
OffshoreRx.com, XlPharmacy
or
SuperSaverMeds.com.
- Avandia Positively Impacts On Factors Linked With Insulin Resistance - Doctor's Guide, 9/18/00
- "Increased deposits of fat around
the internal organs and in the liver are commonly associated with insulin
resistance and are found in many type 2 diabetes patients ... Avandia helps
prevent accumulation of fat around the internal organs and significantly
reduces hepatic fat"
Is
Coffee or Tea Good for Your Liver? - Medscape, 10/2/06 -
"The consumption of coffee and tea
is associated with a reduced risk of CLD"
-
Nutritional
Support in Chronic Liver Disease - Doctor's Guide, 4/21/06
-
Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic
steatosis in patients with non-alcoholic fatty liver disease: a pilot study
- Aliment Pharmacol Ther. 2006 Apr 15;23(8):1143-51 - "non-alcoholic fatty liver disease (NAFLD)
... Supplementation with n-3 PUFA improves biochemical, ultrasonographic and
haemodynamic features of liver steatosis. Our study supports the efficacy of
n-3 PUFA as a new therapeutic approach in the treatment of NAFLD"
-
Coffee and Tea Can Reduce Risk of Chronic Liver Disease - Doctor's
Guide, 12/2/05 - "people at high
risk for liver injury may be able to reduce their risk for developing
chronic liver disease significantly by drinking more than two cups of coffee
or tea daily. This preventative effect was only seen in people at higher
risk for liver disease due to heavy alcohol intake, being overweight or
having diabetes or iron overload"
-
Component Of Green Tea Protects Injured Livers In Mice - Science Daily,
3/9/05
-
Food Can Have Powerful Effect on Health - WebMD, 5/17/04 -
"people who drank more than two cups of coffee a day were about half as likely to have
elevated liver enzyme blood tests compared with those who consumed less than a cup a day. And when divided into five groups according to the total amount of caffeine consumed, people in the highest group had about one-third the risk of liver damage than those in the lowest group"
- Looking for a Liver Cure? - Dr. Weil, 5/13/04
- Weight Loss Helpful in Chronic Liver Disease - Medscape, 2/20/04
-
A
New Era for SAMe - Life Extension Magazine, 6/03
- SAMe Beneficial in Treating Osteoarthritis, Depression, and Liver Disease - New Hope Natural Media, 12/12/02
- Milk Thistle's Liver-Protective Properties - Nutrition Science News, 10/99
- Can Cirrhosis be Prevented? - Nutrition Science News, 1/99
-
SAMe
- Part 3: The Liver Super- Nutrient - Life Extension Magazine, 6/97
CME/CEM:
General Information:
-
Liver Disease - American Academy of Family Physicians
- Liver Disease - emedicine.com
-
Liver Disease - FamilyDoctor.org
- Treatments for liver disorders
- Medifocus.com
Other News:
-
Low
Testosterone as an Independent Predictor of Mortality in Men with Chronic
Liver Disease - Clin Endocrinol (Oxf). 2012 Jan 27 -
"in a Cox proportional hazard model, both low total
(p= 0.02) and free testosterone (p= 0.007) remained predictive of death
independently of established prognostic factors, such as the Model for End
Stage Liver Disease (MELD) score, and serum sodium levels. A decrease in TT
by 1 nmol/L and in cFT by 10 pmol/L was associated with an 8% increase in
mortality"
-
Abnormal liver tests associated with increased death rates in people over 75
- Science Daily, 8/2/11 - "The study covered liver
tests for abnormal levels of asparate transaminase (AST), alkaline
phosphatase (ALP) and bilirubin, with patients being followed up for an
average of just over seven years. The elderly patients with the abnormal
liver tests were compared with patients with normal liver tests ... Abnormal
AST was associated with a sevenfold increased risk of death from liver
disease and a 56% increase in cancer risk ... Abnormal ALP was associated
with nearly a six-fold increased risk of death from liver disease. It also
raised the risk of death from a number of other illnesses: heart disease
(34%), cancer (61%) and respiratory disease (58%) ... Patients who had two
or more elevated liver tests faced a 54% increased risk of all-cause
mortality and the risk of dying from cancer doubled. They were 17 times more
likely to die from liver disease than patients with no abnormal liver tests"
-
Obesity greater risk for fatty liver than moderate amounts of alcohol, study
suggests - Science Daily, 5/30/11 - "It turned
out that the amount of fat in the liver was linked with obesity and insulin
resistance and was almost not at all affected by the red wine. Specifically,
after three months, none of the the wine drinkers had developed fatty liver
or elevated liver transaminases"
-
Plasma
adiponectin-an independent indicator of liver fat accumulation -
Metabolism. 2011 May 10 - "Adiponectin is a very
strong predictor for liver brightness, even after adjustment for the
numerous other metabolic risk factors, markers of inflammation, and novel
obesity-related peptide hormones. Whether low adiponectin levels predict to
liver fat accumulation remains to be explored in a future prospective
follow-up of this cohort"
-
Fatty liver: How a serious problem arises - Science Daily, 4/6/11 -
"Up to 80 percent of obese people develop fatty
liver disease, which is regarded a typical characteristic of the dangerous
metabolic syndrome. Deposition of fat in the liver may lead to chronic liver
inflammation and even to liver cancer. In addition, fatty liver is
considered to be an independent risk factor for coronary heart disease and
atherosclerosis"
-
New
data show non-alcoholic fatty liver disease will reach epidemic status in
the US - Science Daily, 4/2/11 - "if the current
rates of obesity and diabetes continue for another two decades, the
prevalence of NAFLD in the US is expected to increase by 50% in 2030"
-
A
Molecular Link Between Sleep and Liver Fat - nih.gov, 3/21/11 -
"As many as 1 in 4 Americans are estimated to have
excess liver fat, which can lead to inflammation and damage that could
eventually cause liver failure. Fat production in the liver is known to be
affected by circadian rhythms. Past studies have shown that disrupting
circadian rhythms in mice causes the animals to develop excess liver fat.
They also suffer from obesity, diabetes and metabolic syndrome ... during
the day, when mice are asleep and fasting, HDAC3 and rev-erbα help prevent
the liver from producing fat. As predicted, when either protein was removed
from the mouse liver, the fat metabolism genes became active regardless of
time or activity level. This led to a rapid buildup of fat in the liver ...
This may explain in part why altered circadian rhythms in people who do
shift work is associated with metabolic disorders"
-
Mayo
researchers find mortality rates from liver diseases underestimated -
Science Daily, 1/1/10 - "Statistics from the Centers
for Disease Control and Prevention (CDC) rank mortality related to chronic
liver disease and cirrhosis as the 12th most common cause of death in adults
in the U.S. Using a modified definition that includes diseases such as viral
hepatitis, liver cancer and obesity-related fatty liver disease (liver
diseases), Mayo Clinic-led researchers have found that liver-related
mortality is as high as fourth for some age groups [45 and 64 years], and
eighth overall"
-
High doses of ursodeoxycholic acid ineffective for NASH patients, study
suggests - Science Daily, 7/20/10
-
Non-alcoholic fatty liver disease associated with high mortality rates -
Science Daily, 2/1/10
-
Drinking Coffee Slows Progression Of Liver Disease In Chronic Hepatitis C
Sufferers, Study Suggests - Science Daily, 10/24/09 -
"Patients with chronic hepatitis C and advanced
liver disease who drink three or more cups of coffee per day have a 53%
lower risk of liver disease progression than non-coffee drinkers"
-
Second-hand Smoking Results In Liver Disease, Study Finds - Science
Daily, 9/10/09
-
Fat
In The Liver -- Not The Belly -- May Be A Better Marker For Disease Risk
- Science Daily, 8/25/09 - "Having too much liver
fat is known as nonalcoholic fatty liver disease ... when fat collects in
the liver, people experience serious metabolic problems such as insulin
resistance, which affects the body's ability to metabolize sugar. They also
have increases in production of fat particles in the liver that are secreted
into the bloodstream and increase the level of triglycerides"
-
Liver Disease 'Shrunk' By Blood-pressure Drug - Science Daily, 6/2/09 -
"analysed a small clinical trial of losartan, a drug
normally prescribed for hypertension, on 14 patients in Spain, who had
Hepatitis C ... Half of the patients in the trial saw the scars in their
liver shrink allowing the organ to repair itself ... Researchers believe
that the drug blocks the signalling pathway so that the liver myofibroblasts
die, removing the source of scar tissue. As the scar tissue breaks up, the
damaged area of the liver is repaired by the body"
-
Environmental Pollution Increases Risk Of Liver Disease, Study Finds -
Science Daily, 5/29/09
-
Statin Drugs May Protect Against Cancer And Also Result in Fewer Gallbladder
Removals - Science Daily, 5/5/09 - "The research
team found a significant inverse association between having statin
prescriptions filled and the risk of developing HCC. There was a trend
toward stronger risk reduction with longer and more frequent statin
prescriptions"
-
Daily Drinking Rather Than Binge Drinking Is Biggest Risk Factor In Serious
Liver Disease, New Study Finds - Science Daily, 3/20/09
-
Iron
Overload: An Important Co-factor In The Development Of Liver Disease In
Alcoholics - Science Daily, 2/24/09 - "A high
prevalence of iron overload was found in alcoholics, which appeared to be
related to the development of liver disease [odds ration for having liver
disease in alcoholics with transferrin saturation greater than 45% was 2.2
(95% CI 1.37-3.54)]"
-
Hepatitis C Is Killing Liver Cells - Science Daily, 2/5/09
-
Tobacco Smoke And Alcohol Harm Liver Worse As Combo - Science Daily,
2/3/09
-
Fat-free Diet Reduces Liver Fat In Fat-free Mice, Researchers Report -
Science Daily, 2/3/09
-
Fatty Liver Disease Medication May Have No Effect - Science Daily,
1/13/09
-
Antibiotics: Single Largest Class Of Drugs Causing Liver Injury -
Science Daily, 12/8/08 - "Antibiotics are the single
largest class of agents that cause idiosyncratic drug-induced liver injury
(DILI) ... DILI is the most common cause of death from acute liver failure
and accounts for approximately 13 percent of cases of acute liver failure in
the U.S"
- Pioglitazone Improves
Fatty Liver Disease in Nondiabetics - Medscape, 11/5/08
-
New Imaging Technology Accurately Identifies A Broad Spectrum Of Liver
Disease - Science Daily, 11/1/08
-
Angiotensin
receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class
option? - Adv Ther. 2008 Oct 29 - "Nonalcoholic fatty liver disease (NAFLD)
... nonalcoholic steatohepatitis (NASH) ... In our opinion there are two major
advantages of ARBs that make them a possible therapeutic option for treating
NASH and MS: their specific antihypertensive effect, and their impact on liver
fibrosis. In light of this, and based on the current evidence (including
existent human studies), we can speculate that some ARBs like telmisartan,
candesartan, and losartan can be beneficial in treating NASH/NAFLD and its
consequences, and further larger controlled clinical trials will bring
consistent data into this field"
-
Cortisol And Fatty Liver: Researchers Find Cause Of Severe Metabolic
Disorders - Science Daily, 9/11/08 - "The
researchers in Herzig's team specifically switched off the cortisol receptor
in the livers of mice, thus blocking the hormone's effect. As a result, the
triglyceride level in the livers of the experimental animals dropped
considerably"
-
Normal ALT Levels May Mask Advanced Fibrosis In Liver Disease Patients -
Science Daily, 9/4/08
-
The effects of 8 months of metformin on circulating GGT and ALT levels in
obese women with polycystic ovarian syndrome - Int J Clin Pract. 2008
Jun 19 - "treated with metformin 1500 or 2550 mg/day
for 8 months ... Mean weight, serum ALT and GGT decreased from 100.3 to 96.6
kg (p < 0.0001), 29.7 to 25.8 U/l (p = 0.012) and 21.4 to 16.9 U/l (p <
0.0001) respectively ... In women with baseline ALT > 29.7 U/l (median), ALT
reduction was highly significant (p = 0.005); however in those with baseline
ALT < 29.7 U/l, ALT did not change despite similar weight reduction. There
was no difference in reductions in ALT and GGT when the two metformin doses
were compared"
-
Belly Fat May Affect Liver Function - Science Daily, 6/10/08 -
"It has been shown that people who store body fat in
their abdomens are at greater risk to develop diabetes and other chronic
illnesses, but why this happens has remained unclear ... Our study found
lipid release from abdominal fat was substantially elevated during the
night, which may be a primary mechanism leading to insulin resistance, a
strong risk factor for type 2 diabetes"
-
Elevated Liver Enzymes Linked to Development of Diabetes - Medscape,
6/9/08 - "Compared with individuals in the lowest
quintile of GGT, the adjusted hazard ratios (HRs) for incident diabetes were
1.13 for quintile 2, 1.67 for quintile 3, 2.77 for quintile 4, and 2.67 for
quintile 5 (p for linear trend < 0.001). For ALT, the corresponding HRs were
0.93, 1.28, 1.35, and 1.93, respectively"
-
Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease -
Science Daily, 5/29/08 - "For patients with type 2
diabetes, a condition called non-alcoholic fatty liver disease (NAFLD) may
be an important risk factor for diabetes-related chronic kidney disease
(CKD)"
-
Elevated AST, ALT Linked to Higher Future Mortality Rate - Medscape,
4/1/08 - "An abnormal AST up to 2 times ULN was
associated with a 32% increased risk of death, and more than 2 times ULN was
linked to a 78% increase in risk ... An abnormal ALT up to 2 times ULN was
associated with a 21% increase in mortality risk, and more than 2 times ULN
was associated with a 59% increase in risk ... patients with normal AST or
ALT had a lower than expected risk of death (SMR 0.95 for AST and 0.61 for
ALT)"
-
Elevated Liver Enzymes Associated With Higher Future Mortality - Science
Daily, 3/4/08 - "Liver enzymes include aspartate
aminotransferase (AST) and alanine aminotransferase (ALT), and high
concentrations in the blood tend to indicate liver disease ... elevated AST
was associated with a significantly increased standardized mortality rate
(SMR). Elevated ALT was also associated with a higher SMR. The SMRs ranged
between 1.21 and 1.78 ... elevated serum AST and ALT may be markers of
cardiovascular diseases (nearly 34 percent of the deaths in the study
population were due to cardiovascular causes)"
-
Fatty Fast Food, Idleness May Vex Liver - WebMD, 2/13/08 -
"The students were asked to gain 5% to 15% of their
body weight in a month by eating at least two daily meals at fast-food
restaurants and adopting a sedentary lifestyle ... On average, the students
gained 14 pounds, added 2.6 inches to their waistline, and padded their body
fat percentage by 3.7% during the study ... Blood samples provided by the
students throughout the study show a spike in levels of the liver enzyme
alanine aminotransferase (ALT). ALT levels rose quickly -- typically within
a week -- after the students started the fast-food diet"
- Liver damage
'could be reversed' - BBC News, 12/27/07
-
Association between serum TSH, free T4 and serum liver enzyme activities in
a large cohort of unselected outpatients - Clin Endocrinol (Oxf). 2007
Oct 17 - "GGT and ALT concentrations increased
steadily across the increasing TSH categories (P < 0.0001 for trends),
ranging from mean values of 36 to 62 U/l for GGT and from 29 to 41 U/l for
ALT, respectively. Similarly, there was a negative, graded, relationship
between serum GGT and ALT concentrations and free T4 categories"
-
Liver dysfunction in paediatric obesity: a randomized, controlled trial of
metformin - Acta Paediatr. 2007 Sep;96(9):1326-32 -
"In obese adolescents fed ad libitum, metformin (a)
prevented the rise in ALT concentrations that were observed in
placebo-treated subjects at the 3 to 5 month time-points (p < 0.05); (b)
reduced (p < 0.01) the percentage of all ALT values exceeding 40 U/L; and
(c) caused a modest (10%) but statistically significant (p < 0.05) reduction
in serum ALT in Caucasian subjects. Metformin had no effect on ALT levels or
the ALT to AST ratio in the five African American adolescents enrolled in
the study ... metformin might reduce the rates or severity of liver
dysfunction in selected high-risk adolescents"
-
Fatty Liver and the Metabolic Syndrome - Medscape, 3/1/07
-
The association between non-alcoholic fatty liver disease and insulin
resistance in 20 obese children and adolescents - Acta Paediatr. 2007
Jan;96(1):109-12 - "The high
prevalence of insulin resistance we found in children with NAFLD confirms
the suggestion that there may be an association between insulin resistance
and NAFLD in obese children"
-
Elevated ALT Levels Predict Risk of Death From Liver Cancer - Medscape,
11/2/06 - "Upper limits of normal
range from 30 IU/L to 60 IU/L, depending on the laboratory. "We want to
reset it southward of 30 IU/L," ... ALT levels are a reflection of the
general vascular condition ... If the level is above 30, then that person
probably has a problem — fatty liver or some vascular disease, including
occlusive coronary artery disease"
-
Drug 'may reverse liver disease' - BBC News, 9/26/06
-
Combating Fatigue Associated with Liver Disease - Doctor's Guide,
5/25/05
-
New
Ways To Ease Liver Disease - Science Daily, 3/21/05
-
Chronic Liver Failure To Be Treated Using Stem Cell Therapy - Science Daily, 11/15/04
- Stem Cells Can Convert to Liver Tissue, Help Restore Damaged Organ - Doctor's Guide, 6/2/04
- Intra-Arterial Folinic Acid and 5-Flurouracil Effective in Locally Advanced Hepatocarcinoma - Doctor's Guide, 5/19/04
- Obesity Epidemic Invades the Liver - Doctor's Guide, 5/14/04
- Chronic Liver Disease Patients May Have Impaired Driving Skills - Doctor's Guide, 10/31/03
- High-Fat Diet May Protect Liver in Morbidly Obese Patients - Doctor's Guide, 10/30/03
- Liver Function Test Correlates with Histologic Stage and Clinical Status in Patients with Hepatitis C-Related Chronic Liver Disease - Doctor's Guide, 2/20/03
- Hepatitis E Vaccine Recommended For Patients With Chronic Liver Disease - Doctor's Guide, 8/5/02
- Living Liver Donors Report High Satisfaction - Doctor's Guide, 6/24/02
- Recombinant Human Factor VIIa Enables Coagulation in Patients with Advanced Liver Disease - Doctor's Guide, 5/23/02
- Elevated Liver Enzymes in Obese Children - Doctor's Guide, 5/21/02 -
"Childhood obesity may
set the stage for liver damage, with elevated liver enzymes a warning sign ... Of the 90 percent of obese children who did not show elevated enzymes, "all probably had fatty liver" and were at risk for liver damage"
- Pulsatility Index May Help Predict Outcome in Liver Disease Patients - Doctor's Guide, 4/17/02
- New Diabetes Drugs Still Pose Liver Risks - WebMD, 3/19/02
- Steroid Withdrawal Accelerates Bone Mass Recovery After Successful Liver Transplantation - Doctor's Guide, 3/12/02
- Doctors Aware of Acetaminophen-Related Liver Risk, Must Educate Public - Doctor's Guide, 6/18/01
- FDA Probes New Acetaminophen Worry - Intelihealth, 3/27/01 -
"There are warnings not to take it if you consume more than three alcoholic drinks ...
acetaminophen overdoses could be a bigger cause of liver failure than some prescription drugs recently banned for liver poisoning, such as the diabetes medicine Rezulin ... He tracked more than 300 acute liver failure cases at 22 hospitals and linked 38 percent to acetaminophen ... In a second database tracking 307
adults suffering severe liver injury - not full-fledged failure - at six hospitals, Lee linked acetaminophen to 35 percent of cases ... initial symptoms are flu-like and doctors may not promptly test for acetaminophen's hallmark sky-high liver enzymes"
- Scanty Truncal Hair Distribution Occurs in Patients With Alcoholic Liver Disease - Doctor's Guide, 10/18/00
- Women More Likely To Develop Alcohol-Related Liver Disease - Doctor's Guide, 12/9/97
- CFC Alternative Causes Liver Disease - Doctor's Guide, 8/22/97
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