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Anti-aging Research > Curcumin/Turmeric.
Curcumin/Turmeric (Curcuma longa)
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Specific Recommendations:
News & Research:
- Turmeric (Curcuma longa)
- The Natural Pharmacist
- What
is curcumin? - Dr. Murray
-
Indian
spice may delay liver damage and cirrhosis, study suggests - Science Daily,
3/24/10 - "The findings showed that the curcumin diet
significantly reduced bile duct blockage and curbed liver cell (hepatocyte)
damage and scarring (fibrosis) by interfering with several chemical signalling
pathways involved in the inflammatory process"
-
Turmeric
Cream Decreases Signs of Aging - Medscape, 3/16/10 - "A new moisturizing
cream containing turmeric extract, an ingredient found in curry, significantly
improves the appearance of facial spots, fine lines, and wrinkles, according to
results from 2 split-face studies (1 with an all-white and 1 with an all-Asian
patient population) presented here at the American Academy of Dermatology 68th
Annual Meeting"
-
Spices may boost breast health: Study - Nutra USA, 12/9/09 -
"curcumin, found in turmeric, and piperine, found in
black peppers, decreased the number of stem cells while having no effect on
normal differentiated cells ... If we can limit the number of stem cells, we
can limit the number of cells with potential to form tumours ... normal,
non-cancerous stem cells were unaffected by the compounds, which appeared to
selectively target the cancer stem cells" - [Abstract]
-
Targeting breast stem
cells with the cancer preventive compounds curcumin and piperine -
Breast Cancer Res Treat. 2009 Nov 7 - "Both curcumin
and piperine inhibited mammosphere formation, serial passaging, and percent
of ALDH+ cells by 50% at 5 muM and completely at 10 muM concentration in
normal and malignant breast cells. There was no effect on cellular
differentiation. Wnt signaling was inhibited by both curcumin and piperine
by 50% at 5 muM and completely at 10 muM. Curcumin and piperine separately,
and in combination, inhibit breast stem cell self-renewal but do not cause
toxicity to differentiated cells. These compounds could be potential cancer
preventive agents. Mammosphere formation assays may be a quantifiable
biomarker to assess cancer preventive agent efficacy and Wnt signaling
assessment can be a mechanistic biomarker for use in human clinical trials"
-
Curry compound
kills cancer cells, study shows - MSNBC, 10/28/09 - "Researchers at the Cork
Cancer Research Center in Ireland treated esophageal cancer cells with curcumin
— a chemical found in the spice turmeric, which gives curries a distinctive
yellow color — and found it started to kill cancer cells within 24 hours ... But
these cells showed no evidence of suicide, and the addition of a molecule that
inhibits caspases and stops this "switch being flicked' made no difference to
the number of cells that died, suggesting curcumin attacked the cancer cells
using an alternative cell signaling system"
-
Curcumin May Inhibit Nicotine-induced Activation Of Head And Neck Cancers
- Science Daily, 10/4/09 - "HNSCC cells were
pre-treated with curcumin and then nicotine was introduced. The results of
the studies showed that the curcumin was able to block the nicotine from
activating cancer ... Although nicotine itself has not been shown to be
carcinogenic, it has been shown to encourage the cancer-forming process"
-
Vit D-curcumin combo offers brain health potential - Nutra USA, 7/27/09
- "The curcuminoids were found to enhance binding of
beta-amyloid to macrophages, and that vitamin D could strongly stimulate the
uptake and absorption of beta-amyloid in macrophages in most of the patients
... Since vitamin D and curcumin work differently with the immune system, we
may find that a combination of the two or each used alone may be more
effective — depending on the individual patient" - [Abstract]
- See
vitamin D products at iHerb
 and
curcumin/turmeric products at iHerb.
-
Curcumin
delays development of medroxyprogesterone acetate-accelerated
7,12-dimethylbenz[a]anthracene-induced mammary tumors - Menopause. 2009
Jul 22 - "Combined hormone therapy (HT) containing
estrogen and progestin (medroxyprogesterone acetate [MPA]) leads to
increased risk of breast cancer in postmenopausal women, compared with HT
regimens containing estrogen alone or placebo ... Treatment with curcumin
delayed the first appearance of MPA-accelerated tumors by 7 days, decreased
tumor incidence by the end of the experiment, and reduced tumor multiplicity
in DMBA-induced MPA-accelerated tumors. Curcumin also prevented many of the
gross histological changes seen in the MPA-treated mammary gland.
Immunohistochemical analyses of mammary tumors showed that curcumin
decreased MPA-induced VEGF induction in hyperplastic lesions, although it
did not affect the levels of estrogen and progesterone receptors"
-
Curcumin May Prevent Clogged Arteries - WebMD, 7/20/09 -
"The current study suggests curcumin may thwart the
development of atherosclerosis, or clogged arteries, a key risk factor for
heart attacks and strokes ... Researchers in France fed 20 mice a diet
supplemented with curcumin or a comparison diet not supplemented with
curcumin. After 16 weeks, mice fed on the curcumin-based diet had a 26%
reduction in fatty deposits in their arteries compared to mice on the
comparison diet ... In addition, curcumin appeared to alter the genetic
signaling involved in plaque buildup at the molecular level"
-
Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's
Disease - Science Daily, 7/15/09 - "The team
discovered that curcuminoids enhanced the surface binding of amyloid beta to
macrophages and that vitamin D strongly stimulated the uptake and absorption
of amyloid beta in macrophages in a majority of patients ... Since vitamin D
and curcumin work differently with the immune system, we may find that a
combination of the two or each used alone may be more effective — depending
on the individual patient" - See
curcumin/turmeric products at iHerb
and
vitamin D products at iHerb.
-
Asian Spice Could Reduce Breast Cancer Risk In Women Exposed To Hormone
Replacement Therapy - Science Daily, 7/13/09 -
"curcumin, a popular Indian spice derived from the turmeric root, could
reduce the cancer risk for women after exposure to hormone replacement
therapy ... curcumin delayed the first appearance, decreased incidence and
reduced multiplicity of progestin-accelerated tumors in an animal model.
Curcumin also prevented the appearance of gross morphological abnormalities
in the mammary glands"
-
Compound In Turmeric Spice May Stall Spread Of Fat Tissue - Science
Daily, 5/22/09 - "supplementing the animals’
high-fat diet with curcumin reduced body-weight gain and total body fat,
even though food-intake was not affected, when compared to the
nonsupplemented high-fat-diet group ... The curcumin-treated group also had
less blood vessel growth in fat tissue. Blood glucose, triglyceride, fatty
acid, cholesterol and liver fat levels also were lower"
-
Turmeric Extract Suppresses Fat Tissue Growth In Rodent Models - Science
Daily, 5/18/09 - "Curcumin, the major polyphenol
found in turmeric, appears to reduce weight gain in mice and suppress the
growth of fat tissue in mice and cell models"
-
Curcumin may cut body fat and weight gain: Mouse study - Nutra USA,
4/27/09 - "The curcumin suppression of angiogenesis
in adipose tissue together with its effect on lipid metabolism in adipocytes
may contribute to lower body fat and body weight gain ... Curcumin was also
associated with significantly lower cholesterol levels and a reduction in
the expression of peroxisome proliferators-activated receptor gamma
(PPAR-gamma), a protein that plays a role in metabolic functions" - [Abstract]
-
Turmeric: India's 'Holy Powder' Finally Reveals Its Centuries-old Secret
- Science Daily, 4/20/09 - "Using a high-tech
instrument termed solid-state NMR spectroscopy, the scientists discovered
that molecules of curcumin act like a biochemical disciplinarian. They
insert themselves into cell membranes and make the membranes more stable and
orderly in a way that increases cells' resistance to infection by
disease-causing microbes"
-
Turmeric Ingredient Makes Membranes Behave For Better Health - Science
Daily, 3/6/09 - "curcumin acts as a disciplinarian,
inserting itself into cell membranes and making them more orderly, a move
that improves cells' resistance to infection and malignancy ... The membrane
goes from being crazy and floppy to being more disciplined and ordered, so
that information flow through it can be controlled"
-
Curry Spice May Thwart Heart Failure - WebMD, 2/26/08
-
Indian Spice In Turmeric Reduces Size Of Hemorrhagic Stroke - Science
Daily, 9/22/08 - "This active ingredient of the
Indian curry spice, turmeric, not only lowers your chances of getting cancer
and Alzheimer's disease, but may reduce the size of a hemorrhagic stroke ...
significantly decreases the size of a blood clot"
-
Curcumin Suppresses IgE-Mediated Allergic Response and Mast Cell Activation
- Medscape, 6/3/08 - "Two cytokines, TNF-alpha and
IL-4, are among those that are critical to allergic inflammation. In studies
using the RBL-2H3 tumor mast cell line, the researchers found that curcumin
significantly inhibited the antigen-stimulated expression of mRNA for both
cytokines, and the secretion of both cytokines in the mast cells, in a
dose-dependent manner"
-
Ingredient In Yellow Curry Can Reduce Heart Enlargement And May Prevent
Heart Failure - Science Daily, 2/21/08 - "Eating
curcumin, a natural ingredient in the spice turmeric, may dramatically
reduce the chance of developing heart failure"
-
Turmeric
(Curcumin) review - ConsumerLab.com, 2/6/08 -
"ConsumerLab.com found a popular brand to contain 18.7 mcg of lead in a
daily serving — the highest amount it has ever reported. Another brand was
contaminated with 8.3 mcg of lead. These amounts are well above those to
which people are normally exposed and should be avoided ... two other
products provided only 11.5% and 49.5%, respectively, of expected curcumin
compounds. A fifth product did not specify the part of the plant used — a
FDA labeling requirement" - Note: I get the paid version and it
was NSI® Nutraceutical® Sciences Institute Superior™ Turmeric Curcuma Longa
that contained the 18.7 mcg of lead and Solgar® Standardize Full Potency™
Turmeric Root Extract that contained the 8.3 mcg. There wasn't any that
failed that I call "brand name".
-
Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating
growth inhibition of colon cancer cells by modulating EGFR and IGF-1R -
Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to
the conventional chemotherapeutic agent(s)/regimen could be an effective
therapeutic strategy for colorectal cancer"
-
Colon Cancer on curcumin and Vectibix - Johns Hopkins, 8/14/07 -
"University of Texas researchers treated some human
colorectal cancer cells with neurotensin, with and without curcumin. They
confirmed that neurotensin started a chain reaction of chemicals that can
increase the growth of cancer and also the migration of cancer cells and
that curcumin blocked the process ... Curcumin appears to do this by
blocking the biochemical signals sent by neurotensin that contribute to
colon cancer cell growth and migration (the spread of cancer to other body
sites)"
-
Curry Spice May Counter Alzheimer's - WebMD, 7/16/07 -
"In preliminary lab tests, the chemical helped rid
the blood of a key ingredient in Alzheimer's brain plaque"
-
Curcumin's anti-cancer mechanism proposed - Nutra USA, 4/13/07
-
A
Curry A Day Keeps The Doctor Away? - Science Daily, 1/11/07 -
"the chemical compound capsaicin --
which is responsible for the burning sensation when we eat chillies -- can
kill cells by directly targeting their energy source ... It could mean that
patients could control or prevent the onset of cancer by eating a diet rich
in capsaicin"
-
Tasty curry might have a fringe benefit - USA Today, 1/7/07 -
"turmeric, one component of curry
spice, almost completely prevented joint swelling in rats with arthritis.
Other studies have suggested that the spice could protect against diseases
such as heart disease, cancer and Alzheimer's ... many people with arthritis
take over-the-counter supplements that contain curcumin, the active
ingredient in turmeric ... The curcumin in curry seems to shut down genes
that trigger the development and the spread of breast cancer"
-
Turmeric Supplements Show Promise in Treating Arthritis - Medscape,
11/17/06 - "This version was used in
subsequent experiments and was shown to prevent acute and chronic arthritis
... In addition, turmeric significantly inhibited joint destruction due to
arthritis, and inhibited NF-κB, a protein that controls the gene expression
of substances that produce an inflammatory response. Turmeric also altered
the expression of hundreds of genes involved in joint swelling and
destruction and prevented an increase in osteoclasts (cells that break down
bone) in joints"
-
Curry spice extract may have anti-arthritis potential - Nutra USA,
10/30/06 - "Cartilage destruction in
the tibia of the rats was reduced by 66 per cent, and thigh bone mineral
density (BMD) destruction was also reduced by 57 per cent, compared to the
control solution"
-
Curry spice 'help for arthritis' - BBC News, 10/30/06 -
"The extract appears to work by
prevent a protein that controls when genes are switched on or off from being
activated in the joint"
-
Spicy Spin on
Easing Arthritis - WebMD, 10/30/06 -
"Over the next 28 days, the mice in
the turmeric group showed less joint inflammation and less joint damage than
those in the comparison group ... The turmeric extract apparently curbed
certain genes involved in joint inflammation ... The mice in the turmeric
group also showed better bone mineral density than those in the comparison
group"
-
Chemical Found In Curry May Help Immune System Clear Amyloid Plaques Found
In Alzheimer's Disease - Science Daily, 10/3/06 -
"curcumin -- a chemical found in curry and turmeric -- may help the immune
system clear the brain of amyloid beta, which form the plaques found in
Alzheimer's disease"
-
Chemical in Curry
May Cut Colon Cancer - WebMD, 8/2/06 -
"Each of the patients then received
480 milligrams of curcumin and 20 milligrams of quercetin three times a day
for six months ... The results showed that treatment with the curry and
onion compounds reduced the average number of polyps by 60%, and decreased
their size by 50%" - See
iHerb
or
Vitacost
curcumin products and
iHerb
or
Vitacost
quercetin products.
-
Curry And Cauliflower Could Halt Prostate Cancer - Science Daily,
1/15/06 - "The bottom line is that
PEITC and curcumin, alone or in combination, demonstrate significant
cancer-preventive qualities in laboratory mice, and the combination of PEITC
and curcumin could be effective in treating established prostate cancers"
- Turmeric
for Breast Cancer Prevention? - Dr. Weil, 12/2/05
-
Spice Ingredient May Cut Breast Cancer Spread - WebMD, 10/17/05
-
Early Study Shows Spice Stunts Deadly Spread To Lungs - Science Daily,
10/16/05 - "Curcumin ... inhibits
metastasis to the lungs of mice with breast cancer ... Treatment using Taxol
alone only "modestly reduced" the incidence of metastases, while the group
using curcumin alone and curcumin plus Taxol "significantly reduced" both
the incidence and numbers of visible lung metastases"
-
Potent Spice Works To Block Growth Of Melanoma In Lab Test - Science
Daily, 7/14/05
-
Curry Spice May Fight Skin Cancer - WebMD, 7/11/05 -
"curcumin, the yellow pigment found
in the spice turmeric, kills and stops the growth of melanoma skin cancer
cells in laboratory tests"
-
Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 -
"Less than a quarter of the mice in
the curcumin-plus-Taxol group had cancer that spread to the lungs. So did
half of the curcumin group. In comparison, cancer spread to the lungs in
three-fourths of the Taxol group and almost all (95%) mice that got no
treatment"
-
Does a New
Pill Contain the Fountain of Youth? - ABC News, 6/2/05 -
"It is a combination of five plant
ingredients. Two of them are pretty commonplace — green tea and turmeric, a
spice used in Indian cooking"
-
Curry Spice May Fight Alzheimer's Disease - WebMD, 1/5/05 -
"the curry pigment curcumin slows the formation of, and even destroys,
accumulated plaque deposits in mouse brains"
- Food for
thought: Can diet protect memory? - MSNBC, 12/6/04
- "research
increasingly suggests that diet may be important in preventing
Alzheimer's ... older dogs fed a diet rich in antioxidants over several
years were able to perform tasks — and learn new tricks — far better than
fellow canines fed a normal diet ... scientists believe that curcumin, a
spice used in India and known for its anti-inflammatory effects, may prevent
memory loss"
-
Can Curcumin Prevent Alzheimer's Disease? - Life Extension Magazine,
12/04
- The Case for Curry: Turmeric as Medical Treatment
- Natural Foods Merchandiser, 6/04
- Curry May Protect Aging Brain - WebMD, 4/19/04 -
"Small doses of curry could help protect the brain against
Alzheimer's disease -- at least that's the effect in rats"
-
Asian spice shows strong antioxidant powers - Nutra USA, 4/19/04
-
Curcumin Update - Life Extension Magazine, 2/04
- Preventing
Breast Cancer Recurrence? - Dr. Weil, 10/13/03
- Try Turmeric
for MS? - Dr. Weil, 8/12/03
-
Curcumin
helpful in multiple sclerosis model - Dr. Murray, 1/1/03
-
Herb Mix Nixes Prostate Cancer in Lab - WebMD, 12/13/02 -
"A number of recent studies point to COX-2 as an important factor in
cancer-cell growth. In the Columbia studies, Zyflamend
decreased COX-2 activity about as well as a potent COX-2-inhibiting drug ...
The herbal mix is called
Zyflamend, from New Chapter
Inc., and has 10 herbs: holy basil, turmeric,
ginger, green tea, rosemary,
hu
zhang, Chinese goldthread,
barberry, oregano, and Scutellaria
biacalensis"
- Can Herbs
Combat Inflammation? - Dr. Weil, 12/3/02 -
"Take 400 to 600 milligrams of turmeric extracts (available in tablets or
capsules) three times per day or as directed on the product label. Whole
turmeric is more effective than isolated curcumin, its major constituent.
Look for products standardized for 95% curcuminoids. Be patient: the full
benefit takes two months to develop. Don’t use turmeric if you have
gallstones or bile duct dysfunction" - See
iHerb
and
Vitacost
turmeric products.
- Curry Spice Takes Burn Out of Radiation - WebMD,
10/10/02 - "The study showed that
curcumin, the substance in turmeric that gives it and the dishes it flavors
a characteristic yellow color, is a natural anti-inflammatory compound. It
works in ways similar to the popular Cox-2 inhibiting drugs, including
aspirin and Celebrex"
-
A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine,
7/02 - "Imagine a natural substance
so smart it can tell the difference between a cancer cell and a normal cell;
so powerful it can stop chemicals in their tracks; and so strong it can
enable DNA to walk away from lethal doses of radiation virtually unscathed.
Curcumin has powers against cancer so beneficial that drug companies are
rushing to make drug versions. Curcumin is all this and more"
- An Indian
Spice for Alzheimer’s? - Dr. Weil, 6/12/02 -
"Curcumin blocked the accumulation of beta-amaloid
plaque and also appeared to reduce inflammation related to
Alzheimer’s disease in
neurologic
tissue. The rats fed curcumin also performed better on
memory tests than rats on normal diets ... Researchers at the University
of Illinois have also found that it helps prevent plaque formation. And
preliminary studies at Vanderbilt University suggest that curcumin may block
the progression of multiple sclerosis ... only low
dose curcumin reduced plaque in the Alzheimer’s disease studies ... Turmeric
appears to have significant anti-inflammatory
and cancer-protective effects as well"
-
I would like to know if curcumin is safe for long-term use - Life
Extension Magazine, 3/02
-
Are you aware of any studies relating to oral curcumin and serum cholesterol
levels? - Life Extension Magazine, 1/02
-
question regarding your new cholesterol-lowering supplement, Policosanol
- Life Extension Magazine, 11/01 -
"In the Journal of Molecular Cell Biochemistry, curcumin has been
demonstrated, in vivo, to decrease triglycerides and increase HDL."
-
Unlocking the power of curcumin - Life Extension Magazine, 9/01 -
"research is discovering that curcumin
is a powerful carcinogenic inhibitor, slowing cancerous cell proliferation
by inducing apoptosis, a pre-programmed set of processes within a cell that
results in its death"
-
Curcumin protects against mammary tumors in rats - Life Extension
Magazine, 8/01
-
Cholesterol Reduction - Life Extension Magazine -
"human volunteers taking curcumin showed a 29% increase in beneficial HDL
cholesterol in only 7 days. Total cholesterol also fell 11.6% and lipid peroxidation was reduced by 33% ..." & other studies
-
Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science
News, 8/00 - "dose-dependent
treatment of the cells with curcumin suppressed both BA- and PMA-mediated
induction of COX-2 protein, genetic COX-2 expression (as measured by mRNA),
and the synthesis of prostaglandin E2. Most impressive, however, was the
discovery that curcumin directly inhibited the enzymatic activity of COX-2"
-
Cancer Prevention Diet - Nutrition Science News, 8/99 -
"Research suggests that curcumin, the bright yellow flavonoid present in
turmeric (Curcuma longa) roots, selectively inhibits thromboxane production
while sparing prostacyclin. Thromboxane is a potent inflammatory
compound produced by the body in response to injury or irritation. It causes
blood vessels to constrict and the blood to clot, while prostacyclin is an
inflammatory mediator that can respond to tissue injury without leading to
further inflammation. Inhibiting thromboxane prevents excessive inflammatory
response and reduces damage to vascular endothelia. Curcumin has also been
shown to inhibit tobacco smoke mutagenicity, suggesting it may help protect
the vascular endothelia from damage caused by smoking"
-
Chemopreventive effects of carotenoids and curcumin on mouse colon
carcinogenesis - Life Extension Magazine, 6/99
- Turmeric and in-vitro NOS Levels in Acute and Chronic Wounds
- Medscape, 3/99
Abstracts:
-
Curcumin
promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma
cells through an miRNA signaling pathway - Biochem Biophys Res Commun. 2010
Jul 10 - "Curcumin extracted from the rhizomes of C.
longa L has been shown to have inhibitory effects on cancers through its
anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates
that curcumin can overcome drug resistance to classical chemotherapies. Thus,
the mechanisms underlying the antitumor activities of curcumin require further
study. In our study, we first demonstrated that curcumin had anti-cancer effects
on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies
showed that curcumin altered miRNA expression; in particular, significantly
downregulated the expression of miR-186 * in A549/DDP. In addition, transfection
of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and
overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis
in A549/DDP cells. These observations suggest that miR-186 * may serve as a
potential gene therapy target for refractory lung cancer that is sensitive to
curcumin"
-
Curcumin
inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1
expression - Lipids Health Dis. 2010 Apr 19;9(1):40 -
"Curcumin inhibits cholesterol uptake through
suppression of NPC1L1 expression in the intestinal cells"
-
Curcumin
improves insulin resistance in skeletal muscle of rats - Nutr Metab
Cardiovasc Dis. 2010 Mar 12 - "Curcumin improves
muscular insulin resistance by increasing oxidation of fatty acid and glucose,
which is, at least in part, mediated through LKB1-AMPK pathway"
-
Synergistic
role of curcumin with current therapeutics in colorectal cancer: minireview
- Nutr Cancer. 2009 Nov;61(6):842-6 - "Despite the use of surgical resection and
aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma
develop recurrent disease, highlighting the need for improved therapies.
Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma
longa) with no discernable toxicity, has been shown to inhibit the growth of
transformed cells and colon carcinogenesis at the initiation, promotion, and
progression stages in carcinogen-induced rodent models. In a Phase I clinical
trial, curcumin has been found to be extremely well tolerated and effective ...
Existing data suggest that curcumin in combination with chemotherapy is a
superior strategy for treatment of gastrointestinal cancer"
-
Curcumin
suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta
and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children
and adults with inflammatory bowel disease - Br J Nutr. 2009 Nov 2:1-9 -
"We conclude that curcumin, a naturally occurring
food substance with no known human toxicity, holds promise as a novel
therapy in IBD"
-
Curcumin
synergizes with resveratrol to inhibit colon cancer - Nutr Cancer.
2009;61(4):544-53 - "the combination of curcumin and
resveratrol was found to be more effective in inhibiting growth of
p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and
in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either
agent alone. Analysis by Calcusyn software showed synergism between curcumin
and resveratrol. The inhibition of tumors in response to curcumin and/or
resveratrol was associated with the reduction in proliferation and
stimulation of apoptosis accompanied by attenuation of NF-kappaB activity.
In vitro studies have further demonstrated that the combinatorial treatment
caused a greater inhibition of constitutive activation of EGFR and its
family members as well as IGF-1R. Our current data suggest that the
combination of curcumin and resveratrol could be an effective
preventive/therapeutic strategy for colon cancer"
-
1α,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate
Amyloid-β Clearance by Macrophages of Alzheimer's Disease Patient - J
Alzheimers Dis. 2009 May 11 - "1,25D3 strongly
stimulated Abeta phagocytosis and clearance while protecting against
apoptosis. Certain synthetic curcuminoids in combination with 1,25D3 had
additive effects on phagocytosis in Type I but not Type II macrophages. In
addition, we investigated the mechanisms of 1,25D3 and curcuminoids in
macrophages. The 1,25D3 genomic antagonist analog MK inhibited 1,25D3 but
not curcuminoid effects, suggesting that 1,25D3 acts through the genomic
pathway. In silico, 1,25D3 showed preferential binding to the genomic pocket
of the vitamin D receptor, whereas bisdemethoxycurcumin showed preference
for the non-genomic pocket. 1,25D3 is a promising hormone for AD
immunoprophylaxis because in Type I macrophages combined treatment with
1,25D3 and curcuminoids has additive effects, and in Type II macrophages
1,25D3 treatment is effective alone. Human macrophages are a new paradigm
for testing immune therapies for AD" - See
vitamin D products at iHerband
curcumin/turmeric products at iHerb.
-
Curcumin
sensitizes human colorectal cancer to capecitabine by modulation of cyclin
D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model
- Int J Cancer. 2009 May 26 - "Because of the poor
prognosis and the development of resistance against chemotherapeutic drugs,
the current treatment for advanced metastatic colorectal cancer (CRC) is
ineffective. Whether curcumin (a component of turmeric) can potentiate the
effect of capecitabine against growth and metastasis of CRC was investigated
... In nude mice, the combination of curcumin and capecitabine was found to
be more effective than either agent alone in reducing tumor volume (p =
0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation
index (p = 0.001 vs. control) and microvessel density marker CD31. The
combination treatment was also highly effective in suppressing ascites and
distant metastasis to the liver, intestines, lungs, rectum and spleen. This
effect was accompanied by suppressed expression of activated NF-kappaB and
NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1,
COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that
curcumin sensitizes CRC to the antitumor and antimetastatic effects of
capecitabine by suppressing NF-kappaB cell signaling pathway"
-
Curcumin
suppresses expression of low-density lipoprotein (LDL) receptor, leading to
the inhibition of LDL-induced activation of hepatic stellate cells - Br
J Pharmacol. 2009 Jul 7 - "This curcumin, a
constituent of turmeric, may be useful in preventing
hypercholesterolemia-associated hepatic fibrogenesis" - See
curcumin/turmeric products at iHerb.
-
Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and
obesity in C57/BL mice - J Nutr. 2009 May;139(5):919-25 -
"Supplementing the high-fat diet of mice with
curcumin did not affect food intake but reduced body weight gain, adiposity,
and microvessel density in adipose tissue, which coincided with reduced
expression of vascular endothelial growth factor (VEGF) and its receptor
VEGFR-2. Curcumin increased 5'AMP-activated protein kinase phosphorylation,
reduced glycerol-3-phosphate acyl transferase-1, and increased carnitine
palmitoyltransferase-1 expression, which led to increased oxidation and
decreased fatty acid esterification ... Our findings suggest that dietary
curcumin may have a potential benefit in preventing obesity"
-
Curcumin and cancer: An "old-age" disease with an "age-old" solution -
Cancer Lett. 2008 May 5 - "The activity of curcumin
reported against leukemia and lymphoma, gastrointestinal cancers,
genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous
cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma
reflects its ability to affect multiple targets. Thus an "old-age" disease
such as cancer requires an "age-old" treatment"
-
Curcumin
induces cell-arrest and apoptosis in association with the inhibition of
constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma
cells - Int J Cancer. 2008 Apr 3 -
"Interestingly, curcumin caused cell cycle arrest in G2-M and a significant
reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered
cell death by apoptosis, as evidenced by the activation of caspase-3 and
caspase-9, changes in nuclear morphology and phosphatidylserine
translocation. The above findings provide a mechanistic rationale for the
potential use of curcumin as a therapeutic agent for patients with HL"
-
Curcumin stimulates proliferation of embryonic neural progenitor cells and
neurogenesis in the adult hippocampus - J Biol Chem. 2008 Mar 24 -
"Administration of curcumin to adult mice resulted
in a significant increase in the number of newly-generated cells in the
dentate gyrus of hippocampus, indicating that curcumin enhances adult
hippocampal neurogenesis"
-
Effects of curcumin on bladder cancer cells and development of urothelial
tumors in a rat bladder carcinogenesis model - Cancer Lett. 2008 Mar 12
- "Exposure of human bladder cancer cells to
curcumin resulted in the induction of apoptotic cell death and caused cells
to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein
was downregulated by the curcumin treatment together with enhancement of the
Bax and p53 expression. The inhibitory activities of curcumin were stronger
than those of cisplatin and could not be prevented by catalase pretreatment
in T24 cells. Clonal assay indicated large-dose and short-term curcumin was
lethal to bladder cancer cells. Moreover, the in vivo study revealed
curcumin did induce apoptosis in situ, inhibit and slow the development of
bladder cancer. These observations suggest that curcumin could prove an
effective chemopreventive and chemotherapy agent for bladder cancer"
-
The combination of epigallocatechin gallate and curcumin suppresses ERalpha-breast
cancer cell growth in vitro and in vivo - Int J Cancer. 2007 Dec 20 -
"Tumor volume in the EGCG + curcumin treated mice
decreased 49% compared to vehicle control mice (p < 0.05), which correlated
with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the
tumors. Curcumin treatment significantly decreased tumor protein levels of
EGFR and Akt, however the expression of these proteins was not further
decreased following combination treatment. Therefore, these results
demonstrate that the combination of EGCG and curcumin is efficacious in both
in vitro and in vivo models of ERalpha- breast cancer and that regulation of
VEGFR-1 may play a key role in this effect"
-
Effect of Curcumin on Inflammation and Oxidative Stress in Cisplatin-Induced
Experimental Nephrotoxicity - J Agric Food Chem. 2007 Nov 15 -
"curcumin has a protective effect on cisplatin-induced
experimental nephrotoxicity, and this effect is attributed to its direct
anti-inflammatory and strong antioxidant profile. Hence, curcumin has a
strong potential to be used as a therapeutic adjuvant in cisplatin
nephrotoxicity" - See
Curcumin/turmeric products at iHerb.
-
Curcumin for chemoprevention of colon cancer - Cancer Lett. 2007 Apr 18
- "Overwhelming in vitro evidence
and completed clinical trials suggests that curcumin may prove to be useful
for the chemoprevention of colon cancer in humans"
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