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Anti-aging Research > Curcumin/Turmeric.
Curcumin/Turmeric (Curcuma longa)
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Specific Recommendations:
News & Research:
-
Turmeric
- Vitacost Health Library
- Turmeric (Curcuma longa)
- The Natural Pharmacist
- What
is curcumin? - Dr. Murray
-
Curry Spice May Thwart Heart Failure - WebMD, 2/26/08
-
Ingredient In Yellow Curry Can Reduce Heart Enlargement And May Prevent
Heart Failure - Science Daily, 2/21/08 - "Eating
curcumin, a natural ingredient in the spice turmeric, may dramatically
reduce the chance of developing heart failure"
-
Turmeric
(Curcumin) review - ConsumerLab.com, 2/6/08 -
"ConsumerLab.com found a popular brand to contain 18.7 mcg of lead in a
daily serving — the highest amount it has ever reported. Another brand was
contaminated with 8.3 mcg of lead. These amounts are well above those to
which people are normally exposed and should be avoided ... two other
products provided only 11.5% and 49.5%, respectively, of expected curcumin
compounds. A fifth product did not specify the part of the plant used — a
FDA labeling requirement" - Note: I get the paid version and it
was NSI® Nutraceutical® Sciences Institute Superior™ Turmeric Curcuma Longa
that contained the 18.7 mcg of lead and Solgar® Standardize Full Potency™
Turmeric Root Extract that contained the 8.3 mcg. There wasn't any that
failed that I call "brand name".
-
Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating
growth inhibition of colon cancer cells by modulating EGFR and IGF-1R -
Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to
the conventional chemotherapeutic agent(s)/regimen could be an effective
therapeutic strategy for colorectal cancer"
-
Colon Cancer on curcumin and Vectibix - Johns Hopkins, 8/14/07 -
"University of Texas researchers treated some human
colorectal cancer cells with neurotensin, with and without curcumin. They
confirmed that neurotensin started a chain reaction of chemicals that can
increase the growth of cancer and also the migration of cancer cells and
that curcumin blocked the process ... Curcumin appears to do this by
blocking the biochemical signals sent by neurotensin that contribute to
colon cancer cell growth and migration (the spread of cancer to other body
sites)"
-
Curry Spice May Counter Alzheimer's - WebMD, 7/16/07 -
"In preliminary lab tests, the chemical helped rid
the blood of a key ingredient in Alzheimer's brain plaque"
-
Curcumin's anti-cancer mechanism proposed - Nutra USA, 4/13/07
-
A
Curry A Day Keeps The Doctor Away? - Science Daily, 1/11/07 -
"the chemical compound capsaicin --
which is responsible for the burning sensation when we eat chillies -- can
kill cells by directly targeting their energy source ... It could mean that
patients could control or prevent the onset of cancer by eating a diet rich
in capsaicin"
-
Tasty curry might have a fringe benefit - USA Today, 1/7/07 -
"turmeric, one component of curry
spice, almost completely prevented joint swelling in rats with arthritis.
Other studies have suggested that the spice could protect against diseases
such as heart disease, cancer and Alzheimer's ... many people with arthritis
take over-the-counter supplements that contain curcumin, the active
ingredient in turmeric ... The curcumin in curry seems to shut down genes
that trigger the development and the spread of breast cancer"
-
Turmeric Supplements Show Promise in Treating Arthritis - Medscape,
11/17/06 - "This version was used in
subsequent experiments and was shown to prevent acute and chronic arthritis
... In addition, turmeric significantly inhibited joint destruction due to
arthritis, and inhibited NF-κB, a protein that controls the gene expression
of substances that produce an inflammatory response. Turmeric also altered
the expression of hundreds of genes involved in joint swelling and
destruction and prevented an increase in osteoclasts (cells that break down
bone) in joints"
-
Curry spice extract may have anti-arthritis potential - Nutra USA,
10/30/06 - "Cartilage destruction in
the tibia of the rats was reduced by 66 per cent, and thigh bone mineral
density (BMD) destruction was also reduced by 57 per cent, compared to the
control solution"
-
Curry spice 'help for arthritis' - BBC News, 10/30/06 -
"The extract appears to work by
prevent a protein that controls when genes are switched on or off from being
activated in the joint"
-
Spicy Spin on
Easing Arthritis - WebMD, 10/30/06 -
"Over the next 28 days, the mice in
the turmeric group showed less joint inflammation and less joint damage than
those in the comparison group ... The turmeric extract apparently curbed
certain genes involved in joint inflammation ... The mice in the turmeric
group also showed better bone mineral density than those in the comparison
group"
-
Chemical Found In Curry May Help Immune System Clear Amyloid Plaques Found
In Alzheimer's Disease - Science Daily, 10/3/06 -
"curcumin -- a chemical found in curry and turmeric -- may help the immune
system clear the brain of amyloid beta, which form the plaques found in
Alzheimer's disease"
-
Chemical in Curry
May Cut Colon Cancer - WebMD, 8/2/06 -
"Each of the patients then received
480 milligrams of curcumin and 20 milligrams of quercetin three times a day
for six months ... The results showed that treatment with the curry and
onion compounds reduced the average number of polyps by 60%, and decreased
their size by 50%" - See
iHerb
or
Vitacost
curcumin products and
iHerb
or
Vitacost
quercetin products.
-
Curry And Cauliflower Could Halt Prostate Cancer - Science Daily,
1/15/06 - "The bottom line is that
PEITC and curcumin, alone or in combination, demonstrate significant
cancer-preventive qualities in laboratory mice, and the combination of PEITC
and curcumin could be effective in treating established prostate cancers"
- Turmeric
for Breast Cancer Prevention? - Dr. Weil, 12/2/05
-
Spice Ingredient May Cut Breast Cancer Spread - WebMD, 10/17/05
-
Early Study Shows Spice Stunts Deadly Spread To Lungs - Science Daily,
10/16/05 - "Curcumin ... inhibits
metastasis to the lungs of mice with breast cancer ... Treatment using Taxol
alone only "modestly reduced" the incidence of metastases, while the group
using curcumin alone and curcumin plus Taxol "significantly reduced" both
the incidence and numbers of visible lung metastases"
-
Potent Spice Works To Block Growth Of Melanoma In Lab Test - Science
Daily, 7/14/05
-
Curry Spice May Fight Skin Cancer - WebMD, 7/11/05 -
"curcumin, the yellow pigment found
in the spice turmeric, kills and stops the growth of melanoma skin cancer
cells in laboratory tests"
-
Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 -
"Less than a quarter of the mice in
the curcumin-plus-Taxol group had cancer that spread to the lungs. So did
half of the curcumin group. In comparison, cancer spread to the lungs in
three-fourths of the Taxol group and almost all (95%) mice that got no
treatment"
-
Does a New
Pill Contain the Fountain of Youth? - ABC News, 6/2/05 -
"It is a combination of five plant
ingredients. Two of them are pretty commonplace — green tea and turmeric, a
spice used in Indian cooking"
-
Curry Spice May Fight Alzheimer's Disease - WebMD, 1/5/05 -
"the curry pigment curcumin slows the formation of, and even destroys,
accumulated plaque deposits in mouse brains"
- Food for
thought: Can diet protect memory? - MSNBC, 12/6/04
- "research
increasingly suggests that diet may be important in preventing
Alzheimer's ... older dogs fed a diet rich in antioxidants over several
years were able to perform tasks — and learn new tricks — far better than
fellow canines fed a normal diet ... scientists believe that curcumin, a
spice used in India and known for its anti-inflammatory effects, may prevent
memory loss"
-
Can Curcumin Prevent Alzheimer's Disease? - Life Extension Magazine,
12/04
- The Case for Curry: Turmeric as Medical Treatment
- Natural Foods Merchandiser, 6/04
- Curry May Protect Aging Brain - WebMD, 4/19/04 -
"Small doses of curry could help protect the brain against
Alzheimer's disease -- at least that's the effect in rats"
-
Asian spice shows strong antioxidant powers - Nutra USA, 4/19/04
-
Curcumin Update - Life Extension Magazine, 2/04
- Preventing
Breast Cancer Recurrence? - Dr. Weil, 10/13/03
- Try Turmeric
for MS? - Dr. Weil, 8/12/03
-
Curcumin
helpful in multiple sclerosis model - Dr. Murray, 1/1/03
-
Herb Mix Nixes Prostate Cancer in Lab - WebMD, 12/13/02 -
"A number of recent studies point to COX-2 as an important factor in
cancer-cell growth. In the Columbia studies, Zyflamend
decreased COX-2 activity about as well as a potent COX-2-inhibiting drug ...
The herbal mix is called
Zyflamend, from New Chapter
Inc., and has 10 herbs: holy basil, turmeric,
ginger, green tea, rosemary,
hu
zhang, Chinese goldthread,
barberry, oregano, and Scutellaria
biacalensis"
- Can Herbs
Combat Inflammation? - Dr. Weil, 12/3/02 -
"Take 400 to 600 milligrams of turmeric extracts (available in tablets or
capsules) three times per day or as directed on the product label. Whole
turmeric is more effective than isolated curcumin, its major constituent.
Look for products standardized for 95% curcuminoids. Be patient: the full
benefit takes two months to develop. Don’t use turmeric if you have
gallstones or bile duct dysfunction" - See
iHerb
and
Vitacost
turmeric products.
- Curry Spice Takes Burn Out of Radiation - WebMD,
10/10/02 - "The study showed that
curcumin, the substance in turmeric that gives it and the dishes it flavors
a characteristic yellow color, is a natural anti-inflammatory compound. It
works in ways similar to the popular Cox-2 inhibiting drugs, including
aspirin and Celebrex"
-
A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine,
7/02 - "Imagine a natural substance
so smart it can tell the difference between a cancer cell and a normal cell;
so powerful it can stop chemicals in their tracks; and so strong it can
enable DNA to walk away from lethal doses of radiation virtually unscathed.
Curcumin has powers against cancer so beneficial that drug companies are
rushing to make drug versions. Curcumin is all this and more"
- An Indian
Spice for Alzheimer’s? - Dr. Weil, 6/12/02 -
"Curcumin blocked the accumulation of beta-amaloid
plaque and also appeared to reduce inflammation related to
Alzheimer’s disease in
neurologic
tissue. The rats fed curcumin also performed better on
memory tests than rats on normal diets ... Researchers at the University
of Illinois have also found that it helps prevent plaque formation. And
preliminary studies at Vanderbilt University suggest that curcumin may block
the progression of multiple sclerosis ... only low
dose curcumin reduced plaque in the Alzheimer’s disease studies ... Turmeric
appears to have significant anti-inflammatory
and cancer-protective effects as well"
-
I would like to know if curcumin is safe for long-term use - Life
Extension Magazine, 3/02
-
Are you aware of any studies relating to oral curcumin and serum cholesterol
levels? - Life Extension Magazine, 1/02
-
question regarding your new cholesterol-lowering supplement, Policosanol
- Life Extension Magazine, 11/01 -
"In the Journal of Molecular Cell Biochemistry, curcumin has been
demonstrated, in vivo, to decrease triglycerides and increase HDL."
-
Unlocking the power of curcumin - Life Extension Magazine, 9/01 -
"research is discovering that curcumin
is a powerful carcinogenic inhibitor, slowing cancerous cell proliferation
by inducing apoptosis, a pre-programmed set of processes within a cell that
results in its death"
-
Curcumin protects against mammary tumors in rats - Life Extension
Magazine, 8/01
-
Cholesterol Reduction - Life Extension Magazine -
"human volunteers taking curcumin showed a 29% increase in beneficial HDL
cholesterol in only 7 days. Total cholesterol also fell 11.6% and lipid peroxidation was reduced by 33% ..." & other studies
-
Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science
News, 8/00 - "dose-dependent
treatment of the cells with curcumin suppressed both BA- and PMA-mediated
induction of COX-2 protein, genetic COX-2 expression (as measured by mRNA),
and the synthesis of prostaglandin E2. Most impressive, however, was the
discovery that curcumin directly inhibited the enzymatic activity of COX-2"
-
Cancer Prevention Diet - Nutrition Science News, 8/99 -
"Research suggests that curcumin, the bright yellow flavonoid present in
turmeric (Curcuma longa) roots, selectively inhibits thromboxane production
while sparing prostacyclin. Thromboxane is a potent inflammatory
compound produced by the body in response to injury or irritation. It causes
blood vessels to constrict and the blood to clot, while prostacyclin is an
inflammatory mediator that can respond to tissue injury without leading to
further inflammation. Inhibiting thromboxane prevents excessive inflammatory
response and reduces damage to vascular endothelia. Curcumin has also been
shown to inhibit tobacco smoke mutagenicity, suggesting it may help protect
the vascular endothelia from damage caused by smoking"
-
Chemopreventive effects of carotenoids and curcumin on mouse colon
carcinogenesis - Life Extension Magazine, 6/99
- Turmeric and in-vitro NOS Levels in Acute and Chronic Wounds
- Medscape, 3/99
Abstracts:
-
Curcumin and cancer: An "old-age" disease with an "age-old" solution -
Cancer Lett. 2008 May 5 - "The activity of curcumin
reported against leukemia and lymphoma, gastrointestinal cancers,
genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous
cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma
reflects its ability to affect multiple targets. Thus an "old-age" disease
such as cancer requires an "age-old" treatment"
-
Curcumin
induces cell-arrest and apoptosis in association with the inhibition of
constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma
cells - Int J Cancer. 2008 Apr 3 -
"Interestingly, curcumin caused cell cycle arrest in G2-M and a significant
reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered
cell death by apoptosis, as evidenced by the activation of caspase-3 and
caspase-9, changes in nuclear morphology and phosphatidylserine
translocation. The above findings provide a mechanistic rationale for the
potential use of curcumin as a therapeutic agent for patients with HL"
-
Curcumin stimulates proliferation of embryonic neural progenitor cells and
neurogenesis in the adult hippocampus - J Biol Chem. 2008 Mar 24 -
"Administration of curcumin to adult mice resulted
in a significant increase in the number of newly-generated cells in the
dentate gyrus of hippocampus, indicating that curcumin enhances adult
hippocampal neurogenesis"
-
Effects of curcumin on bladder cancer cells and development of urothelial
tumors in a rat bladder carcinogenesis model - Cancer Lett. 2008 Mar 12
- "Exposure of human bladder cancer cells to
curcumin resulted in the induction of apoptotic cell death and caused cells
to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein
was downregulated by the curcumin treatment together with enhancement of the
Bax and p53 expression. The inhibitory activities of curcumin were stronger
than those of cisplatin and could not be prevented by catalase pretreatment
in T24 cells. Clonal assay indicated large-dose and short-term curcumin was
lethal to bladder cancer cells. Moreover, the in vivo study revealed
curcumin did induce apoptosis in situ, inhibit and slow the development of
bladder cancer. These observations suggest that curcumin could prove an
effective chemopreventive and chemotherapy agent for bladder cancer"
-
The combination of epigallocatechin gallate and curcumin suppresses ERalpha-breast
cancer cell growth in vitro and in vivo - Int J Cancer. 2007 Dec 20 -
"Tumor volume in the EGCG + curcumin treated mice
decreased 49% compared to vehicle control mice (p < 0.05), which correlated
with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the
tumors. Curcumin treatment significantly decreased tumor protein levels of
EGFR and Akt, however the expression of these proteins was not further
decreased following combination treatment. Therefore, these results
demonstrate that the combination of EGCG and curcumin is efficacious in both
in vitro and in vivo models of ERalpha- breast cancer and that regulation of
VEGFR-1 may play a key role in this effect"
-
Effect of Curcumin on Inflammation and Oxidative Stress in Cisplatin-Induced
Experimental Nephrotoxicity - J Agric Food Chem. 2007 Nov 15 -
"curcumin has a protective effect on cisplatin-induced
experimental nephrotoxicity, and this effect is attributed to its direct
anti-inflammatory and strong antioxidant profile. Hence, curcumin has a
strong potential to be used as a therapeutic adjuvant in cisplatin
nephrotoxicity" - See
Curcumin/turmeric products at iHerb.
-
Curcumin for chemoprevention of colon cancer - Cancer Lett. 2007 Apr 18
- "Overwhelming in vitro evidence
and completed clinical trials suggests that curcumin may prove to be useful
for the chemoprevention of colon cancer in humans"
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