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Home > Anti-aging Research > Curcumin/Turmeric.

Curcumin/Turmeric (Curcuma longa)

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News & Research:

  • Turmeric (Curcuma longa) - The Natural Pharmacist
  • What is curcumin? - Dr. Murray
  • Indian spice may delay liver damage and cirrhosis, study suggests - Science Daily, 3/24/10 - "The findings showed that the curcumin diet significantly reduced bile duct blockage and curbed liver cell (hepatocyte) damage and scarring (fibrosis) by interfering with several chemical signalling pathways involved in the inflammatory process"
  • Turmeric Cream Decreases Signs of Aging - Medscape, 3/16/10 - "A new moisturizing cream containing turmeric extract, an ingredient found in curry, significantly improves the appearance of facial spots, fine lines, and wrinkles, according to results from 2 split-face studies (1 with an all-white and 1 with an all-Asian patient population) presented here at the American Academy of Dermatology 68th Annual Meeting"
  • Spices may boost breast health: Study - Nutra USA, 12/9/09 - "curcumin, found in turmeric, and piperine, found in black peppers, decreased the number of stem cells while having no effect on normal differentiated cells ... If we can limit the number of stem cells, we can limit the number of cells with potential to form tumours ... normal, non-cancerous stem cells were unaffected by the compounds, which appeared to selectively target the cancer stem cells" - [Abstract]
  • Targeting breast stem cells with the cancer preventive compounds curcumin and piperine - Breast Cancer Res Treat. 2009 Nov 7 - "Both curcumin and piperine inhibited mammosphere formation, serial passaging, and percent of ALDH+ cells by 50% at 5 muM and completely at 10 muM concentration in normal and malignant breast cells. There was no effect on cellular differentiation. Wnt signaling was inhibited by both curcumin and piperine by 50% at 5 muM and completely at 10 muM. Curcumin and piperine separately, and in combination, inhibit breast stem cell self-renewal but do not cause toxicity to differentiated cells. These compounds could be potential cancer preventive agents. Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials"
  • Curry compound kills cancer cells, study shows - MSNBC, 10/28/09 - "Researchers at the Cork Cancer Research Center in Ireland treated esophageal cancer cells with curcumin — a chemical found in the spice turmeric, which gives curries a distinctive yellow color — and found it started to kill cancer cells within 24 hours ... But these cells showed no evidence of suicide, and the addition of a molecule that inhibits caspases and stops this "switch being flicked' made no difference to the number of cells that died, suggesting curcumin attacked the cancer cells using an alternative cell signaling system"
  • Curcumin May Inhibit Nicotine-induced Activation Of Head And Neck Cancers - Science Daily, 10/4/09 - "HNSCC cells were pre-treated with curcumin and then nicotine was introduced. The results of the studies showed that the curcumin was able to block the nicotine from activating cancer ... Although nicotine itself has not been shown to be carcinogenic, it has been shown to encourage the cancer-forming process"
  • Vit D-curcumin combo offers brain health potential - Nutra USA, 7/27/09 - "The curcuminoids were found to enhance binding of beta-amyloid to macrophages, and that vitamin D could strongly stimulate the uptake and absorption of beta-amyloid in macrophages in most of the patients ... Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient" - [Abstract] - See vitamin D products at iHerband curcumin/turmeric products at iHerb.
  • Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors - Menopause. 2009 Jul 22 - "Combined hormone therapy (HT) containing estrogen and progestin (medroxyprogesterone acetate [MPA]) leads to increased risk of breast cancer in postmenopausal women, compared with HT regimens containing estrogen alone or placebo ... Treatment with curcumin delayed the first appearance of MPA-accelerated tumors by 7 days, decreased tumor incidence by the end of the experiment, and reduced tumor multiplicity in DMBA-induced MPA-accelerated tumors. Curcumin also prevented many of the gross histological changes seen in the MPA-treated mammary gland. Immunohistochemical analyses of mammary tumors showed that curcumin decreased MPA-induced VEGF induction in hyperplastic lesions, although it did not affect the levels of estrogen and progesterone receptors"
  • Curcumin May Prevent Clogged Arteries - WebMD, 7/20/09 - "The current study suggests curcumin may thwart the development of atherosclerosis, or clogged arteries, a key risk factor for heart attacks and strokes ... Researchers in France fed 20 mice a diet supplemented with curcumin or a comparison diet not supplemented with curcumin. After 16 weeks, mice fed on the curcumin-based diet had a 26% reduction in fatty deposits in their arteries compared to mice on the comparison diet ... In addition, curcumin appeared to alter the genetic signaling involved in plaque buildup at the molecular level"
  • Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease - Science Daily, 7/15/09 - "The team discovered that curcuminoids enhanced the surface binding of amyloid beta to macrophages and that vitamin D strongly stimulated the uptake and absorption of amyloid beta in macrophages in a majority of patients ... Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient" - See curcumin/turmeric products at iHerb and vitamin D products at iHerb.
  • Asian Spice Could Reduce Breast Cancer Risk In Women Exposed To Hormone Replacement Therapy - Science Daily, 7/13/09 - "curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women after exposure to hormone replacement therapy ... curcumin delayed the first appearance, decreased incidence and reduced multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands"
  • Compound In Turmeric Spice May Stall Spread Of Fat Tissue - Science Daily, 5/22/09 - "supplementing the animals’ high-fat diet with curcumin reduced body-weight gain and total body fat, even though food-intake was not affected, when compared to the nonsupplemented high-fat-diet group ... The curcumin-treated group also had less blood vessel growth in fat tissue. Blood glucose, triglyceride, fatty acid, cholesterol and liver fat levels also were lower"
  • Turmeric Extract Suppresses Fat Tissue Growth In Rodent Models - Science Daily, 5/18/09 - "Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models"
  • Curcumin may cut body fat and weight gain: Mouse study - Nutra USA, 4/27/09 - "The curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain ... Curcumin was also associated with significantly lower cholesterol levels and a reduction in the expression of peroxisome proliferators-activated receptor gamma (PPAR-gamma), a protein that plays a role in metabolic functions" - [Abstract]
  • Turmeric: India's 'Holy Powder' Finally Reveals Its Centuries-old Secret - Science Daily, 4/20/09 - "Using a high-tech instrument termed solid-state NMR spectroscopy, the scientists discovered that molecules of curcumin act like a biochemical disciplinarian. They insert themselves into cell membranes and make the membranes more stable and orderly in a way that increases cells' resistance to infection by disease-causing microbes"
  • Turmeric Ingredient Makes Membranes Behave For Better Health - Science Daily, 3/6/09 - "curcumin acts as a disciplinarian, inserting itself into cell membranes and making them more orderly, a move that improves cells' resistance to infection and malignancy ... The membrane goes from being crazy and floppy to being more disciplined and ordered, so that information flow through it can be controlled"
  • Curry Spice May Thwart Heart Failure - WebMD, 2/26/08
  • Indian Spice In Turmeric Reduces Size Of Hemorrhagic Stroke - Science Daily, 9/22/08 - "This active ingredient of the Indian curry spice, turmeric, not only lowers your chances of getting cancer and Alzheimer's disease, but may reduce the size of a hemorrhagic stroke ... significantly decreases the size of a blood clot"
  • Curcumin Suppresses IgE-Mediated Allergic Response and Mast Cell Activation - Medscape, 6/3/08 - "Two cytokines, TNF-alpha and IL-4, are among those that are critical to allergic inflammation. In studies using the RBL-2H3 tumor mast cell line, the researchers found that curcumin significantly inhibited the antigen-stimulated expression of mRNA for both cytokines, and the secretion of both cytokines in the mast cells, in a dose-dependent manner"
  • Ingredient In Yellow Curry Can Reduce Heart Enlargement And May Prevent Heart Failure - Science Daily, 2/21/08 - "Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure"
  • Turmeric (Curcumin) review - ConsumerLab.com, 2/6/08 - "ConsumerLab.com found a popular brand to contain 18.7 mcg of lead in a daily serving — the highest amount it has ever reported. Another brand was contaminated with 8.3 mcg of lead. These amounts are well above those to which people are normally exposed and should be avoided ... two other products provided only 11.5% and 49.5%, respectively, of expected curcumin compounds. A fifth product did not specify the part of the plant used — a FDA labeling requirement" - Note:  I get the paid version and it was NSI® Nutraceutical® Sciences Institute Superior™ Turmeric Curcuma Longa that contained the 18.7 mcg of lead and Solgar® Standardize Full Potency™ Turmeric Root Extract that contained the 8.3 mcg. There wasn't any that failed that I call "brand name".
  • Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R - Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer"
  • Colon Cancer on curcumin and Vectibix - Johns Hopkins, 8/14/07 - "University of Texas researchers treated some human colorectal cancer cells with neurotensin, with and without curcumin. They confirmed that neurotensin started a chain reaction of chemicals that can increase the growth of cancer and also the migration of cancer cells and that curcumin blocked the process ... Curcumin appears to do this by blocking the biochemical signals sent by neurotensin that contribute to colon cancer cell growth and migration (the spread of cancer to other body sites)"
  • Curry Spice May Counter Alzheimer's - WebMD, 7/16/07 - "In preliminary lab tests, the chemical helped rid the blood of a key ingredient in Alzheimer's brain plaque"
  • Curcumin's anti-cancer mechanism proposed - Nutra USA, 4/13/07
  • A Curry A Day Keeps The Doctor Away? - Science Daily, 1/11/07 - "the chemical compound capsaicin -- which is responsible for the burning sensation when we eat chillies -- can kill cells by directly targeting their energy source ... It could mean that patients could control or prevent the onset of cancer by eating a diet rich in capsaicin"
  • Tasty curry might have a fringe benefit - USA Today, 1/7/07 - "turmeric, one component of curry spice, almost completely prevented joint swelling in rats with arthritis. Other studies have suggested that the spice could protect against diseases such as heart disease, cancer and Alzheimer's ... many people with arthritis take over-the-counter supplements that contain curcumin, the active ingredient in turmeric ... The curcumin in curry seems to shut down genes that trigger the development and the spread of breast cancer"
  • Turmeric Supplements Show Promise in Treating Arthritis - Medscape, 11/17/06 - "This version was used in subsequent experiments and was shown to prevent acute and chronic arthritis ... In addition, turmeric significantly inhibited joint destruction due to arthritis, and inhibited NF-κB, a protein that controls the gene expression of substances that produce an inflammatory response. Turmeric also altered the expression of hundreds of genes involved in joint swelling and destruction and prevented an increase in osteoclasts (cells that break down bone) in joints"
  • Curry spice extract may have anti-arthritis potential - Nutra USA, 10/30/06 - "Cartilage destruction in the tibia of the rats was reduced by 66 per cent, and thigh bone mineral density (BMD) destruction was also reduced by 57 per cent, compared to the control solution"
  • Curry spice 'help for arthritis' - BBC News, 10/30/06 - "The extract appears to work by prevent a protein that controls when genes are switched on or off from being activated in the joint"
  • Spicy Spin on Easing Arthritis - WebMD, 10/30/06 - "Over the next 28 days, the mice in the turmeric group showed less joint inflammation and less joint damage than those in the comparison group ... The turmeric extract apparently curbed certain genes involved in joint inflammation ... The mice in the turmeric group also showed better bone mineral density than those in the comparison group"
  • Chemical Found In Curry May Help Immune System Clear Amyloid Plaques Found In Alzheimer's Disease - Science Daily, 10/3/06 - "curcumin -- a chemical found in curry and turmeric -- may help the immune system clear the brain of amyloid beta, which form the plaques found in Alzheimer's disease"
  • Chemical in Curry May Cut Colon Cancer - WebMD, 8/2/06 - "Each of the patients then received 480 milligrams of curcumin and 20 milligrams of quercetin three times a day for six months ... The results showed that treatment with the curry and onion compounds reduced the average number of polyps by 60%, and decreased their size by 50%" - See iHerb or Vitacosticon curcumin products and iHerb or Vitacosticon quercetin products.
  • Curry And Cauliflower Could Halt Prostate Cancer - Science Daily, 1/15/06 - "The bottom line is that PEITC and curcumin, alone or in combination, demonstrate significant cancer-preventive qualities in laboratory mice, and the combination of PEITC and curcumin could be effective in treating established prostate cancers"
  • Turmeric for Breast Cancer Prevention? - Dr. Weil, 12/2/05
  • Spice Ingredient May Cut Breast Cancer Spread - WebMD, 10/17/05
  • Early Study Shows Spice Stunts Deadly Spread To Lungs - Science Daily, 10/16/05 - "Curcumin ... inhibits metastasis to the lungs of mice with breast cancer ... Treatment using Taxol alone only "modestly reduced" the incidence of metastases, while the group using curcumin alone and curcumin plus Taxol "significantly reduced" both the incidence and numbers of visible lung metastases"
  • Potent Spice Works To Block Growth Of Melanoma In Lab Test - Science Daily, 7/14/05
  • Curry Spice May Fight Skin Cancer - WebMD, 7/11/05 - "curcumin, the yellow pigment found in the spice turmeric, kills and stops the growth of melanoma skin cancer cells in laboratory tests"
  • Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 - "Less than a quarter of the mice in the curcumin-plus-Taxol group had cancer that spread to the lungs. So did half of the curcumin group. In comparison, cancer spread to the lungs in three-fourths of the Taxol group and almost all (95%) mice that got no treatment"
  • Does a New Pill Contain the Fountain of Youth? - ABC News, 6/2/05 - "It is a combination of five plant ingredients. Two of them are pretty commonplace — green tea and turmeric, a spice used in Indian cooking"
  • Curry Spice May Fight Alzheimer's Disease - WebMD, 1/5/05 - "the curry pigment curcumin slows the formation of, and even destroys, accumulated plaque deposits in mouse brains"
  • Food for thought: Can diet protect memory? - MSNBC, 12/6/04 - "research increasingly suggests that diet may be important in preventing Alzheimer's ... older dogs fed a diet rich in antioxidants over several years were able to perform tasks — and learn new tricks — far better than fellow canines fed a normal diet ... scientists believe that curcumin, a spice used in India and known for its anti-inflammatory effects, may prevent memory loss"
  • Can Curcumin Prevent Alzheimer's Disease? - Life Extension Magazine, 12/04
  • The Case for Curry: Turmeric as Medical Treatment - Natural Foods Merchandiser, 6/04
  • Curry May Protect Aging Brain - WebMD, 4/19/04 - "Small doses of curry could help protect the brain against Alzheimer's disease -- at least that's the effect in rats"
  • Asian spice shows strong antioxidant powers - Nutra USA, 4/19/04
  • Curcumin Update - Life Extension Magazine, 2/04
  • Preventing Breast Cancer Recurrence? - Dr. Weil, 10/13/03
  • Try Turmeric for MS? - Dr. Weil, 8/12/03
  • Curcumin helpful in multiple sclerosis model - Dr. Murray, 1/1/03
  • Herb Mix Nixes Prostate Cancer in Lab - WebMD, 12/13/02 - "A number of recent studies point to COX-2 as an important factor in cancer-cell growth. In the Columbia studies, Zyflamend decreased COX-2 activity about as well as a potent COX-2-inhibiting drug ... The herbal mix is called Zyflamend, from New Chapter Inc., and has 10 herbs: holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano, and Scutellaria biacalensis"
  • Can Herbs Combat Inflammation? - Dr. Weil, 12/3/02 - "Take 400 to 600 milligrams of turmeric extracts (available in tablets or capsules) three times per day or as directed on the product label. Whole turmeric is more effective than isolated curcumin, its major constituent. Look for products standardized for 95% curcuminoids. Be patient: the full benefit takes two months to develop. Don’t use turmeric if you have gallstones or bile duct dysfunction" - See iHerb and Vitacosticon turmeric products.
  • Curry Spice Takes Burn Out of Radiation - WebMD, 10/10/02 - "The study showed that curcumin, the substance in turmeric that gives it and the dishes it flavors a characteristic yellow color, is a natural anti-inflammatory compound. It works in ways similar to the popular Cox-2 inhibiting drugs, including aspirin and Celebrex"
  • A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine, 7/02 - "Imagine a natural substance so smart it can tell the difference between a cancer cell and a normal cell; so powerful it can stop chemicals in their tracks; and so strong it can enable DNA to walk away from lethal doses of radiation virtually unscathed. Curcumin has powers against cancer so beneficial that drug companies are rushing to make drug versions. Curcumin is all this and more"
  • An Indian Spice for Alzheimer’s? - Dr. Weil, 6/12/02 - "Curcumin blocked the accumulation of beta-amaloid plaque and also appeared to reduce inflammation related to Alzheimer’s disease in neurologic tissue. The rats fed curcumin also performed better on memory tests than rats on normal diets ... Researchers at the University of Illinois have also found that it helps prevent plaque formation. And preliminary studies at Vanderbilt University suggest that curcumin may block the progression of multiple sclerosis ... only low dose curcumin reduced plaque in the Alzheimer’s disease studies ... Turmeric appears to have significant anti-inflammatory and cancer-protective effects as well"
  • I would like to know if curcumin is safe for long-term use - Life Extension Magazine, 3/02
  • Are you aware of any studies relating to oral curcumin and serum cholesterol levels? - Life Extension Magazine, 1/02
  • question regarding your new cholesterol-lowering supplement, Policosanol - Life Extension Magazine, 11/01 - "In the Journal of Molecular Cell Biochemistry, curcumin has been demonstrated, in vivo, to decrease triglycerides and increase HDL."
  • Unlocking the power of curcumin - Life Extension Magazine, 9/01 - "research is discovering that curcumin is a powerful carcinogenic inhibitor, slowing cancerous cell proliferation by inducing apoptosis, a pre-programmed set of processes within a cell that results in its death"
  • Curcumin protects against mammary tumors in rats - Life Extension Magazine, 8/01
  • Cholesterol Reduction - Life Extension Magazine - "human volunteers taking curcumin showed a 29% increase in beneficial HDL cholesterol in only 7 days. Total cholesterol also fell 11.6% and lipid peroxidation was reduced by 33% ..." & other studies
  • Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science News, 8/00 - "dose-dependent treatment of the cells with curcumin suppressed both BA- and PMA-mediated induction of COX-2 protein, genetic COX-2 expression (as measured by mRNA), and the synthesis of prostaglandin E2. Most impressive, however, was the discovery that curcumin directly inhibited the enzymatic activity of COX-2"
  • Cancer Prevention Diet - Nutrition Science News, 8/99 - "Research suggests that curcumin, the bright yellow flavonoid present in turmeric (Curcuma longa) roots, selectively inhibits thromboxane production while sparing prostacyclin. Thromboxane is a potent inflammatory compound produced by the body in response to injury or irritation. It causes blood vessels to constrict and the blood to clot, while prostacyclin is an inflammatory mediator that can respond to tissue injury without leading to further inflammation. Inhibiting thromboxane prevents excessive inflammatory response and reduces damage to vascular endothelia. Curcumin has also been shown to inhibit tobacco smoke mutagenicity, suggesting it may help protect the vascular endothelia from damage caused by smoking"
  • Chemopreventive effects of carotenoids and curcumin on mouse colon carcinogenesis - Life Extension Magazine, 6/99
  • Turmeric and in-vitro NOS Levels in Acute and Chronic Wounds - Medscape, 3/99

Abstracts:

  • Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway - Biochem Biophys Res Commun. 2010 Jul 10 - "Curcumin extracted from the rhizomes of C. longa L has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the antitumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186 * in A549/DDP. In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186 * may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin"
  • Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression - Lipids Health Dis. 2010 Apr 19;9(1):40 - "Curcumin inhibits cholesterol uptake through suppression of NPC1L1 expression in the intestinal cells"
  • Curcumin improves insulin resistance in skeletal muscle of rats - Nutr Metab Cardiovasc Dis. 2010 Mar 12 - "Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway"
  • Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview - Nutr Cancer. 2009 Nov;61(6):842-6 - "Despite the use of surgical resection and aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma develop recurrent disease, highlighting the need for improved therapies. Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma longa) with no discernable toxicity, has been shown to inhibit the growth of transformed cells and colon carcinogenesis at the initiation, promotion, and progression stages in carcinogen-induced rodent models. In a Phase I clinical trial, curcumin has been found to be extremely well tolerated and effective ... Existing data suggest that curcumin in combination with chemotherapy is a superior strategy for treatment of gastrointestinal cancer"
  • Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease - Br J Nutr. 2009 Nov 2:1-9 - "We conclude that curcumin, a naturally occurring food substance with no known human toxicity, holds promise as a novel therapy in IBD"
  • Curcumin synergizes with resveratrol to inhibit colon cancer - Nutr Cancer. 2009;61(4):544-53 - "the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Analysis by Calcusyn software showed synergism between curcumin and resveratrol. The inhibition of tumors in response to curcumin and/or resveratrol was associated with the reduction in proliferation and stimulation of apoptosis accompanied by attenuation of NF-kappaB activity. In vitro studies have further demonstrated that the combinatorial treatment caused a greater inhibition of constitutive activation of EGFR and its family members as well as IGF-1R. Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer"
  • 1α,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid-β Clearance by Macrophages of Alzheimer's Disease Patient - J Alzheimers Dis. 2009 May 11 - "1,25D3 strongly stimulated Abeta phagocytosis and clearance while protecting against apoptosis. Certain synthetic curcuminoids in combination with 1,25D3 had additive effects on phagocytosis in Type I but not Type II macrophages. In addition, we investigated the mechanisms of 1,25D3 and curcuminoids in macrophages. The 1,25D3 genomic antagonist analog MK inhibited 1,25D3 but not curcuminoid effects, suggesting that 1,25D3 acts through the genomic pathway. In silico, 1,25D3 showed preferential binding to the genomic pocket of the vitamin D receptor, whereas bisdemethoxycurcumin showed preference for the non-genomic pocket. 1,25D3 is a promising hormone for AD immunoprophylaxis because in Type I macrophages combined treatment with 1,25D3 and curcuminoids has additive effects, and in Type II macrophages 1,25D3 treatment is effective alone. Human macrophages are a new paradigm for testing immune therapies for AD" - See vitamin D products at iHerband curcumin/turmeric products at iHerb.
  • Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model - Int J Cancer. 2009 May 26 - "Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated ... In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31. The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway"
  • Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells - Br J Pharmacol. 2009 Jul 7 - "This curcumin, a constituent of turmeric, may be useful in preventing hypercholesterolemia-associated hepatic fibrogenesis" - See curcumin/turmeric products at iHerb.
  • Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice - J Nutr. 2009 May;139(5):919-25 - "Supplementing the high-fat diet of mice with curcumin did not affect food intake but reduced body weight gain, adiposity, and microvessel density in adipose tissue, which coincided with reduced expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2. Curcumin increased 5'AMP-activated protein kinase phosphorylation, reduced glycerol-3-phosphate acyl transferase-1, and increased carnitine palmitoyltransferase-1 expression, which led to increased oxidation and decreased fatty acid esterification ... Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity"
  • Curcumin and cancer: An "old-age" disease with an "age-old" solution - Cancer Lett. 2008 May 5 - "The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus an "old-age" disease such as cancer requires an "age-old" treatment"
  • Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells - Int J Cancer. 2008 Apr 3 - "Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL"
  • Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus - J Biol Chem. 2008 Mar 24 - "Administration of curcumin to adult mice resulted in a significant increase in the number of newly-generated cells in the dentate gyrus of hippocampus, indicating that curcumin enhances adult hippocampal neurogenesis"
  • Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model - Cancer Lett. 2008 Mar 12 - "Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer"
  • The combination of epigallocatechin gallate and curcumin suppresses ERalpha-breast cancer cell growth in vitro and in vivo - Int J Cancer. 2007 Dec 20 - "Tumor volume in the EGCG + curcumin treated mice decreased 49% compared to vehicle control mice (p < 0.05), which correlated with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the tumors. Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment. Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERalpha- breast cancer and that regulation of VEGFR-1 may play a key role in this effect"
  • Effect of Curcumin on Inflammation and Oxidative Stress in Cisplatin-Induced Experimental Nephrotoxicity - J Agric Food Chem. 2007 Nov 15 - "curcumin has a protective effect on cisplatin-induced experimental nephrotoxicity, and this effect is attributed to its direct anti-inflammatory and strong antioxidant profile. Hence, curcumin has a strong potential to be used as a therapeutic adjuvant in cisplatin nephrotoxicity" - See Curcumin/turmeric products at iHerb.
  • Curcumin for chemoprevention of colon cancer - Cancer Lett. 2007 Apr 18 - "Overwhelming in vitro evidence and completed clinical trials suggests that curcumin may prove to be useful for the chemoprevention of colon cancer in humans"

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