To address the growing use of ad blockers we now use affiliate links to sites like Amazon.com, streaming services, and others. Affiliate links help sites like QualityCounts.com stay open. Affiliate links cost you nothing but help me support my family. We do not allow paid reviews on this site. As an Amazon Associate I earn from qualifying purchases.  Also, you can donate  to ben@qualitycounts.com via Zelle or PayPal.  Click here for the PayPal QR.  Click here for Bitcoin QR code or Bitcoin address: 39muDw6WpQV8j6EdA8eUBvT5iFDiVpVpiE
Home ReliableRXPharmacy Past Newsletters Amazon.com Contact
 Sign-up for newsletter 
 Newsletter Archive
 Newsletter via RSS Feed
 Research on Supplements
 Health Conditions
 Anti-aging Recommendations
 Insulin and Aging
 QualityCounts.com in Time
 Longevity Affiliates:

Home > Anti-aging Research > Cortisol


Cortisol reducing supplements:

Related Topics:

Popular Supplements thought to Reduce Cortisol:

Medications that may reduce cortisol:

The important news:

  • Oncology Pipeline | Pasireotide (SOM230) - A Multigland Somatostatin Analogue | Novartis Oncology
  • Letrozole, a new oral non-steroidal aromastase inhibitor in treating postmenopausal patients with advanced breast cancer. A pilot study - .oxfordjournals.org - "There was a statistically significant decrease in plasma cortisol, which appeared clinically irrelevant since all values remained within the normal range"
  • Mortality and Morbidity in Cushing's Syndrome in New Zealand - Clin Endocrinol (Oxf). 2011 May 24 - "36 patients died during follow-up compared with 8.8 expected deaths (SMR 4.1, 95%CI 2.9-5.6) ... CS is associated with both high mortality and a high prevalence of co-morbidities, even when biochemical cure rates are between 80-90"
  • Older age memory loss tied to stress hormone receptor in brain - Science Daily, 4/6/11 - "one receptor was activated by low levels of cortisol, which helped memory. However, once levels of this stress hormone were too high they spilled over onto a second receptor. This activates brain processes that contribute to memory impairment ... high levels of the stress hormone in aged mice made them less able to remember how to navigate a maze. The memory recall problem was reversed when the receptor linked to poor memory was blocked ... lowering the levels of these stress hormones will prevent them from activating a receptor in the brain that is bad for memory ... The researchers are currently investigating a new chemical compound which blocks an enzyme -- 11beta-HSD1 -- that is involved in producing stress hormones within cells"
  • High blood cortisol levels significantly increases death rate in patients with acute coronary syndrome - Science Daily, 5/27/10 - "1036 patients with acute coronary syndrome were studied for an average period of 7.7 years. There were no significant differences in the serum cortisol levels between patients with and without acute coronary syndrome. However, the patients with ACS and high cortisol levels had a significantly elevated number of deaths when compared to the patients with ACS and the lowest cortisol levels. 758 total deaths were reported during the follow-up period. The ACS patients with the highest cortisol levels (i.e. the highest 25% serum cortisol) were significantly more likely to die from fatal cardiovascular events than those with the lowest cortisol levels (the lowest 25% serum cortisol). (The hazard ratio for highest versus lowest quartile of SCC was 1.89"
  • The relationship of serum and salivary cortisol levels to male sexual dysfunction as measured by the International Index of Erectile Function - Int J Impot Res. 2009 May 7 - "testosterone (T) and cortisol (F) ... (Total-T, Free-T, Bioavailable-T, Total-F and Bioavailable-F) and salivary hormones (Saliva-T and Saliva-F) ... International Index of Erectile Function (IIEF) ... Free-T and Bioavailable-T showed significant inverse correlations with age (P<0.01). In the group not taking antidepressants, the levels of Bioavailable-F and Saliva-F showed significant inverse correlations with a portion of the IIEF score (P<0.05). However, reductions in Bioavailable-T and Saliva-T showed no association with the IIEF score. In the group taking antidepressants, these hormone levels showed no correlation with IIEF"
  • Effects of phosphatidylserine supplementation on exercising humans - Sports Med. 2006;36(8):657-69 - "S-PtdSer 800 mg/day reduced the cortisol response to overtraining during weight training while improving feeling of well-being and decreasing perceived muscle soreness"
  • Associations of salivary cortisol with cognitive function in the Baltimore memory study - Arch Gen Psychiatry. 2007 Jul;64(7):810-8 - "Higher levels of pretest and mean cortisol as well as the area under the curve of cortisol over the study visit were associated with worse performance (P < .05) in 6 domains (language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, and visual memory). For instance, an interquartile range increase in the area under the curve was equivalent to a decrease in the language score expected from an increase in 5.6 (95% confidence interval, 4.2-7.1) years of age"
  • Chronic Exposure To Stress Hormone Causes Anxious Behavior In Mice - Science Daily, 4/17/06 - "Scientists already knew that many people with depression have high levels of cortisol, a human stress hormone, but it wasn't clear whether that was a cause or effect. Now it appears likely that long-term exposure to cortisol actually contributes to the symptoms of depression"
  • Pharmacologic management of Cushing syndrome : new targets for therapy - Treat Endocrinol. 2005;4(2):87-94 - "Compounds with neuromodulatory properties have been effective in only a limited number of cases of hypothalamic-pituitary-dependent Cushing disease, the most common form of Cushing syndrome. These agents include serotonin antagonists (cyproheptadine, ketanserin, ritanserin), dopamine agonists (bromocriptine, cabergoline), GABA agonists (valproic acid [sodium valproate]), and somatostatin analogs (octreotide). Interesting new avenues at the pituitary level involve the potential use of thiazolidinedione compounds, such as rosiglitazone, and of retinoic acid, which are ligands of different nuclear hormone receptors involved in hypothalamic-pituitary regulation"
  • Diabetes Drugs May Help Cushing's Syndrome - Reuters Wire, 11/07/2002 - "Cushing's syndrome results from high levels of the hormone cortisol, and can cause fat accumulation in the upper body and face, and thinning of the arms and legs. Patients can experience high blood pressure and high blood sugar, along with depression, fatigue, irritability and weakened bones ... a protein called PPAR-gamma, which is found on pituitary gland tumor cells, appears to be linked to overproduction of ACTH ... researchers injected mice with ACTH-secreting pituitary tumor cells and then treated them with commonly used diabetes drugs, rosiglitazone (Avandia) and troglitazone, or an inactive placebo ... There was an 85% reduction in ACTH and a corresponding 96% reduction in their cortisol-like hormone"
  • Mirtazapine Regulates Stress Hormones, Improves Sleep In Depressed Patients - Doctor's Guide, 8/8/01 - "Mirtazipine might be the best option for depressed patients with sleep disturbance and irregularities in stress hormone function ... Depression is often accompanied by sleep disturbance -- subjective and objective -- as well as [hypothalamic-pituitary-adrenal] HPA-axis dysregulation ... Mirtazapine is a treatment that [profoundly affects] the HPA-axis within hours and promotes sleep within days ... They tested the 24-hour urinary free cortisol (UFC) levels of 16 healthy men and 20 men and women with major depression ... mirtazipne significantly reduced UFC concentrations, which is often elevated in depressed patients"
  • Cortisol - Keeping a Dangerous Hormone in Check - Life Extension Magazine, 7/04 - "daily cortisol production increased by 54% from a group of 21- to 30-year-old men to a group of men over 70 ... Phosphatidylserine, DHEA, and ginkgo biloba all have been shown to reduce the amount of cortisol produced during stressful events, and these stress fighters can help retard the negative consequences of this hormone" - See iHerb phosphatidylserine products.
  • The Role of Cortisol and Depression: Exploring New Opportunities for Treatments - Psychiatric Times, 5/04 - "Although glucocorticoid production is essential for survival, overproduction is associated with a significant disruption of cellular functioning, which, in turn, leads to widespread physiological dysfunction ... Cortisol, a glucocorticoid released from the adrenal cortex, is the end product of the HPA axis ... The physiological function of DHEA and its sulphated metabolite (DHEA-S) is unclear, but these circulating corticosteroids have been shown to possess antiglucocorticoid properties, and high cortisol/DHEA ratios are reported to be associated with persistent depression"
  • Why Are So Many Women Depressed? - Scientific America Women's Health: A Life Long Guide, Summer 1998 (see the subtopic "Stress and Cortisol") - "It is unclear whether depression is a cause or a consequence of elevated cortisol levels, but the two are undoubtedly related."
  • Wilson's Reverse T3 Dominance Syndrome - knoxintegrativemed.com - "However, when a person experiences prolonged stress, the adrenal glands respond by manufacturing a large amount of cortisol. Cortisol inhibits the conversion of T4 to T3 and favors the conversion of T4 to RT3. If stress is prolonged, a condition called Reverse T3 Dominance occurs and persists even after the stress passes and cortisol levels fall. Apparently, RT3 itself acts like cortisol and blocks the conversion of T4 to T3"
  • Wilson's Syndrome - providentmedical.com - "We know that elevated amounts of cortisol, the major stress hormone, can block 5 prime deiodinase, keeping T4 from being converted to T3.  This results in most of the T4 being converted into reverse T3, which then needs the available 5 prime deiodinase to be converted into T2."
  • Low-Dose DHEA Increases Androgen, Estrogen Levels in Menopause - Medscape, 12/12/03 - "Cortisol F plasma levels progressively decreased throughout the study." - See iHerb DHEA products.
  • A diet fortified with L-lysine and L-arginine reduces plasma cortisol and blocks anxiogenic response to transportation in pigs - Nutr Neurosci. 2003 Oct;6(5):283-9
  • Fish oil prevents the adrenal activation elicited by mental stress in healthy men - Diabetes Metab. 2003 Jun;29(3):289-295 - "In control conditions, mental stress significantly increased heart rate, mean blood pressure, and energy expenditure. It increased plasma epinephrine from 60.9 +/- 6.2 to 89.3 +/- 16.1 pg/ml (p<0.05), plasma cortisol from 291 +/- 32 to 372 +/- 37 micromol/l ... After 3 weeks of a diet supplemented with n-3 fatty acids, the stimulation by mental stress of plasma epinephrine, cortisol, energy expenditure, and plasma non esterified fatty acids concentrations, were all significantly blunted ... Supplementation with n-3 fatty acids inhibits the adrenal activation elicited by a mental stress" - See Mega Twin EPA at Amazon.com.
  • Disappointing Data Confound Claims For DHEA Effectiveness [against Alzheimer's] - Psychiatric News, 6/6/03 - "DHEA has been reported to reduce cortisol, the so-called "stress hormone," which in response to stress is released in large quantities that have been linked to neuronal stress and damage" -  Does anyone detect bias in that title?  I don't know if DHEA helps Alzheimer's or not but I feel the title should have been something like "Alzheimer's Shows Trend Toward Improvement with DHEA at 3 Months".  Their attitude seems to be that nothing works except what we write prescriptions for.  The way I understand it, Alzheimer's usually gets worse, not better and cholinesterase inhibitors slow the disease, they don't reverse it and three months is a short time to determine if it is working.  For example, see the following  in the same issue of Clinical Psychiatry News.  See iHerb DHEA products. - Ben
  • Light Sleeper, Heavy Gainer - HealthDay, 2/14/03 - "Sleep deprivation can increase production of cortisol, a stress hormone that stimulates the appetite"
  • Stress, Cortisol and Health - Supplement Watch Newsletter, 10/02 - "several lines of evidence have converged to solidify the concept that stress makes us fat (because of cortisol), thins our bones (because of cortisol), shrinks our brains (because of cortisol), suppresses our immune system (because of cortisol), saps our energy levels (because of cortisol), and kills our sex drive (because of cortisol) ... Take a daily multivitamin/multi-mineral supplement - because calcium, magnesium, vitamin C and B-complex vitamins are needed for a proper stress response ... Chief among the supplements with documented cortisol-controlling effects are Phosphatidylserine, Beta-sitosterol, Magnolia bark, Theanine, Epimedium, Ashwagandha and Passionflower"
  • Phosphatidylserine (PS) The Essential Brain Nutrient - Life Extension Magazine, 9/02 - "Among its list of functions, phosphatidylserine stimulates the release of dopamine (a mood regulator that also control physical sensations, and movement), increases the production of acetylcholine (necessary for learning and memory), enhances brain glucose metabolism (the fuel used for brain activity), reduces cortisol levels (a stress hormone), and boosts the activity of nerve growth factor (NGF), which oversees the health of cholinergic neurons"
  • A Supplement to Prevent Alzheimer’s - Dr. Weil, 8/20/02 - "In theory, PS works by strengthening cell membranes thus protecting them and their contents from damage, particularly from the stress hormone cortisol"
  • Testosterone Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 - "We know that as cortisol rises, testosterone levels tend to drop"
  • Hypercortisolemia Cited in Link Between Depression and Cardiovascular Disorders - Doctor's Guide, 4/9/02 - "Depressed patients who are also hypercortisolemic appear to have resistance to insulin and increased visceral fat, possibly accounting for a link between major depression and cardiovascular disorders"
  • Physical and Psychological Effects of Stress - MedicineNet.com, 2/02 - "Under excessive stress, we tend to produce cortisol, the classic anti-stress hormone produced by our body, perhaps to conserve energy. However the side-effect here is sexual dysfunction and infertility as cortisol also inhibits production of the hormones essential for sexual"
  • Errant Enzyme Causes Big Bellies - WebMD, 12/11/01 - "They looked at an enzyme called 11-beta hydroxysteroid dehydrogenase type 1. This enzyme is able to increase the level of cortisol in fat cells without raising the level of cortisol in the blood"
  • Single enzyme to blame for potbellies: study - MSNBC, 12/6/01 - "What they found was that a single enzyme in fat cells that raises levels of cortisol — the “fight or flight” stress hormone — triggers fat accumulation around the belly and its associated ill effects ... The researchers were drawn to the role of cortisol because patients with a rare illness known as Cushing syndrome — who have too much of the steroid hormone in their blood — develop severe obesity concentrated around their middles and become diabetic ... Since overweight people without Cushing syndrome typically don’t have too much cortisol in their bloodstreams, Flier hypothesized that they may be producing high cortisol levels solely in their fat cells — possibly because the enzyme HSD-1, which makes cortisol from an inactive molecule, is overactive ... The level of cortisol in their stomach fat tissue was 15 percent to 30 percent higher than in their non-engineered counterparts" - Note: The way I read this article, the final culprit is still the cortisol and there are ways to reduce cortisol now.
  • Retinoic acid prevents experimental Cushing syndrome - J Clin Invest, October 2001, Volume 108, Number 8, 1123-1131 - "This glucocorticoid excess produces abnormal fat deposition, adrenal hyperplasia, thinning of the skin, hypertension, and psychological disturbances"
  • Sleep Deprivation May Trigger Insulin Resistance - Clinical Psychiatry News, 10/01 - "sleep deprivation leads to the release of tumor necrosis factor-, which triggers cortisol release, and that, in turn, causes insulin resistance"
  • Researchers Explore New Meds for Mood Disorders - Clinical Psychiatry News, 10/01 - "Another approach being developed for patients with high levels of circulating cortisol involves the abortion pill mifepristone ... The findings, to be published this month in the Journal of Clinical Psychopharmacology, suggest that a rapid antidepressant response (approximately 7 days) may occur in some patients"
  • Researchers Hopeful Antidepressant Augmentation Will Improve Remission - Clinical Psychiatry News, 9/01 - "In psychotic depression, a corticosteroid antagonist looks most promising. Mifepristone, which is used to induce abortions but was originally designed as treatment for Cushing's disease, has achieved rapid reversal of symptoms in some 30 psychotically depressed patients, ostensibly by blocking cortisol receptors. The drug is now being investigated in a large double-blind trial, he said"
  • Two studies implying that cortisol is the cause, not the result of depression:
  • Procaine HCI - aidsmap.com, 6/28/01
  • AACE Clinical Practice Guidelines For The Evaluation and Treatment of Male Sexual Dysfunction - American Association of Clinical Endocrinologists - "Other endocrine disorders that may cause libido or erectile difficulties include hypothyroidism, hyperthyroidism, adrenal insufficiency, or excessive levels of adrenal corticosteroids [cortisol]"
  • How You React to Stress May Affect How Your Clothes Fit - WebMD, 1/16/01 - "fat created by cortisol is the "deep-belly" kind, which, one expert says, is known to increase health risks"
  • RU-486 could aid variety of ills - MSNBC, 11/2/00 - "RU-486's ability to block the action of a different hormone cortisol has prompted doctors to try it for psychotic depression. In addition to feeling sad and worthless, people with this devastating condition have distorted thinking and often suffer delusions or hallucinations. Many
    become suicidal.

    They have very, very disturbing and crazy thoughts ... and they have no ability to suppress them, said Joseph K. Belanoff, a California psychiatrist who is chief executive officer of Corcept Therapeutics Inc., a small pharmaceutical company. Corcept is sponsoring a study of RU-486 for psychotic depression.

    Several lines of evidence have led researchers to suspect that some of the symptoms of psychotic depression are caused by an excess of cortisol in the brain. Cortisol levels rise in response to stress and may be abnormally elevated in depressed individuals. Similar symptoms can occur in patients with Cushing's syndrome, an overabundance of cortisol usually caused by a tumor, and RU-486 has cured the mental disturbance in some
    such cases.

    Our feeling has been that a lot of the cognitive problems and delusions that you see in some of the patients are due to the [cortisol], said Alan F. Schatzberg, chairman of the psychiatry department at Stanford University School of Medicine, where researchers are conducting a study that will test RU-486 on 30 patients with psychotic depression.

    RU-486 or other cortisol-blocking drugs may be better alternatives than ... some of the typical treatments such as antipsychotic drugs or electric shock therapy, he said."
  • Neuroscience finds foggy link between depression and memory loss - CNN, 4/18/00 - "Studies show that prolonged depression or stress leads to elevated levels of cortisol, a "stress" hormone produced by the adrenal glands. This in turn appears to shrink or atrophy the hippocampus, the sea-horse shaped part of the brain associated with many kinds of memory and learning."
  • STGI Announces Anticort's FDA Phase I/II is Moving Forward - aegis.com, 7/28/99 - "Procaine (the active ingredient of Anticort(TM)) has been used clinically for more than 40 years, primarily as the local injectable anesthetic Novocaine. Despite the widespread use of procaine, reports of side effects have been rare, and are usually associated with excessive dosage, rapid absorption or inadvertent intravascular injection ... For the pharmacokinetics study, participants will receive Anticort(TM) at a single oral dose of 200 mg (cohort A), 400 mg (cohort B), 600 mg (cohort C) or 800 mg (cohort D). For the 8-week continuous dosing study, participants will receive 200 mg (1 pill per day; cohort A), 400 mg (1 pill twice daily; cohort B), 600 mg (1 pill three times daily; cohort C) or 800 mg (2 pills twice daily; cohort D). To ensure the safety of each dose level, these cohorts will be enrolled sequentially"
  • Study Supports Role Of Anticort In Treating Alzheimer's, HIV - Doctor's Guide, 4/17/98 - "Cortisol's role as a cause of disease is most recently confirmed in a study to be published in the May issue of the journal Nature Neuroscience. Authored by Dr. Sonia Lupien of McGill University, the study reports that high levels of cortisol play a key role in Alzheimer's, memory loss, shrinkage of the brain and aging. Dr. Lupien also states that such illnesses might be prevented with medications to reduce elevated cortisol levels."
  • Georgetown Researchers Report Development of New Way to Control Excess Cortisol Levels - Georgetown University Medical Center, 6/12/00 - "Although more work is needed to understand how Anticort works, these results clearly indicate that we now have a powerful tool to control the stress response and its detrimental effects on the body"
  • Endocrinology of Aging - Medscape, 3/00 - "Excessive lifelong adrenal cortisol feedback on the brain may exacerbate the aging-associated loss in neuronal synapses and plasticity"
  • Hypericum, Drug Interatcions, and Liver Effects  - MedHerb.com, 2/00 - "Endogenous hormones metabolized by the CYP3A enzyme system - estradiol, estriol, testosterone, cortisol"
  • The Neurobiology of Depression - Scientific America, 6/98 - "When a threat to physical or psychological well-being is detected, the hypothalamus amplifies production of corticotropin-releasing factor (CRF), which induces the pituitary to secrete ACTH. ACTH then instructs the adrenal gland atop each kidney to release cortisol"
  • Acetyl-L-carnitine in Alzheimer disease: a short-term study on CSF neurotransmitters and neuropeptides - Alzheimer Dis Assoc Disord 1995 Fall;9(3):128-31 - "beta-endorphins significantly decreased after treatment; plasma cortisol levels matched this reduction. Since both CSF beta-endorphins and plasma cortisol decreased, one possible explanation is that ALCAR reduced the AD-dependent hypothalamic-pituitary-adrenocortical (HPA) axis hyperactivity"
  • Psychotic Depression - healthyplace.com - "Researchers aren't exactly sure what causes major depressive disorder with psychotic features (psychotic depression), but it's frequently associated with high levels in the blood of a hormone called cortisol"
  • Gerovital GH-3 information - International Antiaging Systems - "It is also known that Gerovital-H3 can help reduce cortisol levels, the hormone responsible for stress and a rare hormone in that it is one of the few that increases with age. It is believed that high-cortisol levels lead to accelerated aging because cortisol “attacks” the hypothalamus, the area of the brain that “controls” the endocrine system. Ironically cortisol may run out-of-control due to its ability to damage the hypothalamus that controls the adrenal glands that produce cortisol!" - Note:  I'm not a doctor but the way I understand it, GH-3 (procaine HCl) reduces 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) activity.  This is what statins do to lower cholesterol.  Cortisol is made from cholesterol therefore less cholesterol equals less cortisol.  The company making Anticort (procaine HCl), stopped after phase II studies.  See J Pharmacol Exp Ther. 2003 Dec;307(3):1148-57. Epub 2003 Oct 14.  - Ben

Effects of cortisol on thyroid:

  • central hypothyroidism---fibromyalgia, hypothyroidism, thyroid hormone resistance - drlowe.com - "During stress (such as surgery or an auto accident), the adrenal glands increase their secretion of cortisol. The increase in cortisol inhibits the thyroid system in two ways: (1) it decreases TSH secretion by the pituitary gland, and (2) it decreases conversion of T4 to T3"
  • Wilson's Reverse T3 Dominance Syndrome - knoxintegrativemed.com - "However, when a person experiences prolonged stress, the adrenal glands respond by manufacturing a large amount of cortisol. Cortisol inhibits the conversion of T4 to T3 and favors the conversion of T4 to RT3. If stress is prolonged, a condition called Reverse T3 Dominance occurs and persists even after the stress passes and cortisol levels fall. Apparently, RT3 itself acts like cortisol and blocks the conversion of T4 to T3"
  • Wilson's Syndrome - providentmedical.com - "We know that elevated amounts of cortisol, the major stress hormone, can block 5 prime deiodinase, keeping T4 from being converted to T3.  This results in most of the T4 being converted into reverse T3, which then needs the available 5 prime deiodinase to be converted into T2."
  • Wilson's Thyroid Syndrome - "Conversion of T4 to T3 can also be impaired by glucocorticoids" - Maybe that is the mechanism by which cortisol causes depression, and if so, could T3 then cure the depression? - Ben, Related article:
  • Use OF T3 Thyroid Hormone to Treat Depression - DrMirkin.com, 5/11/01 - "some people become depressed when they take just T4 and their depression can be cured when they take both thyroid hormones, T3 and T4"

Alternative News:

  • Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study - Antioxidants (Basel) 2022 Oct 28 - "Pomegranates are known to possess anti-hypertensive, anti-atherogenic and cardioprotective effects mainly due to their pleiotropic effects on various cellular pathways, especially those triggered by oxidative stress ... Urinary total phenolics excretion and antioxidant capacity were significantly increased after 14 and 28 days of PE intake. At day 28, there were also statistically significant decreases in systolic and diastolic blood pressure (BP), pulse wave velocity, body fat and fat mass, as well as an increase in lean body mass. Significant changes in the placebo group were not found. Glucocorticoid levels showed a significant decrease in saliva cortisol at day 28 (morning) in the PE group, and cortisol/cortisone ratio was significantly decreased following 28 days of PE intake at morning, noon, and evening. Urine free cortisol was significantly reduced at day 14. These findings suggest that pomegranate extract intake may improve antioxidant and oxidative stress status and play a beneficial role in the attenuation of some cardiovascular risk factors" - See pomegranate extract at Amazon.com.
  • Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men - Eur J Clin Nutr 2021 Aug 4 - "Lactococcus lactis subsp. cremoris (YRC3780), which is isolated from kefir, has been associated with anti-allergic effects in humans ... Our study suggests that daily intake of YRC3780 improves the HPA axis response to acute psychological stress, which might be associated with a decrease in morning cortisol levels" - See kefir at Amazon.com.
  • The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professional youth soccer players: a double blind, randomized, placebo-controlled trial - J Int Soc Sports Nutr 2021 Mar 4 - "Betaine supplementation may enhance body composition outcomes when supplemented chronically during an exercise program. The purpose of this study was to evaluate the effect of betaine supplementation on development-related hormones, body composition, and anthropometrics in professional youth soccer players during a competitive season ... Twenty-nine players (age, 15.45 ± 0.25 years) were matched based upon position and then randomly assigned to a betaine group (2 g/day; n = 14, BG) or placebo group ... testosterone to cortisol ratio (T/C) ... Betaine supplementation increased testosterone levels and T/C ratio in youth professional soccer players during a competitive season. Betaine supplementation had no negative effects on growth (height and weight) and may attenuate reductions in testosterone due to intense training during puberty" - Note:  I which they would state whether it's betaine hydrochloride [HCl] or betaine anhydrous (trimethylglycine (TMG)).  It must be TMG because HCL is for digestion. - See betaine hydrochloride products at Amazon.com and betaine anhydrous (TMG) at Amazon.com.
    • Betaine HCl – Remembering the Basics - edu.emersonecologics.com - "Trimethylglycine (TMG) is a popular molecule in the betaine family – consisting of the amino acid glycine with three methyl groups attached. TMGs main uses are as either a primary (reducing homocysteine into L-methionine for cardio-protection) or secondary (affecting folate and SAMEe metabolism) methyl donor. For clarity it’s important to remember that the terms “TMG” and “betaine” are used interchangeably ... While still in the same molecular family, betaine hydrochloride [HCl] is a very different molecule. It is a protonated form of TMG, meaning it will give up or transfer a proton and a chloride ion in an aqueous solution (liquid). This makes betaine HCl a very good dietary source of hydrochloric or gastric acid"
  • Long-Term Effect of Combination of Creatine Monohydrate Plus β-Hydroxy β-Methylbutyrate (HMB) on Exercise-Induced Muscle Damage and Anabolic/Catabolic Hormones in Elite Male Endurance Athletes - Biomolecules. 2020 Jan 15;10(1) - "randomized into four different groups: placebo group (PLG; n = 7), CrM group (CrMG; 0.04 g/kg/day of CrM; n = 7), HMB group (HMBG; 3 g/day of HMB; n = 7), and CrM-HMB group (CrM-HMBG; 0.04 g/kg/day of CrM plus 3 g/day of HMB; n = 7) ... we observed significant differences in CrM-HMBG with respect to PLG, CrMG, and HMBG on testosterone (p = 0.006; η2p = 0.454) and the testosterone/cortisol ratio (T/C; p = 0.032; η2p = 0.349). Moreover, we found a synergistic effect of combined supplementation on testosterone (CrM-HMBG = -63.85% vs. CrMG + HMBG = -37.89%) and T/C (CrM-HMBG = 680% vs. CrMG + HMBG = 57.68%) and an antagonistic effect on cortisol (CrM-HMBG = 131.55% vs. CrMG + HMBG = 389.99%). In summary, the combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation. Moreover, this combination presented a synergistic effect on testosterone and T/C and an antagonistic effect on cortisol compared with the sum of individual or isolated supplementation" - [Nutra USA] - See creatine at Amazon.com and  HMB at Amazon.com.
  • A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients - Medscape, 5/9/19 - "A relative increase in cortisol may reflect the presence of stress and stimulate muscle catabolism, whereas a relative decrease in DHEA-S may cause a decrease in the anabolic action of DHEA on muscle; the combination of these factors may lead to sarcopenia" - See 7-keto DHEA at Amazon.com.
  • Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study - Benef Microbes. 2019 Apr 19 - "One hundred and eleven (n=111; DR7 n=56, placebo n=55) stressed adults were recruited based on moderate stress levels using the PSS-10 questionnaire. The consumption of DR7 (1×109 cfu/day) for 12 weeks reduced symptoms of stress (P=0.024), anxiety (P=0.001), and total psychological scores (P=0.022) as early as 8 weeks among stressed adults compared to the placebo group as assessed by the DASS-42 questionnaire. Plasma cortisol level was reduced among DR7 subjects as compared to the placebo, accompanied by reduced plasma pro-inflammatory cytokines, such as interferon-γ and transforming growth factor-α and increased plasma anti-inflammatory cytokines, such as interleukin 10 (P<0.05). DR7 better improved cognitive and memory functions in normal adults (>30 years old), such as basic attention, emotional cognition, and associate learning (P<0.05), as compared to the placebo and young adults (<30 years old). The administration of DR7 enhanced the serotonin pathway, as observed by lowered expressions of plasma dopamine β-hydroxylase (DBH), tyrosine hydroxylase (TH), indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine receptor-6, while stabilising the dopamine pathway as observed via stabilised expressions of TH and DBH over 12 weeks as compared to the placebo" - [Nutra USA] - See probiotic products at Amazon.com.
  • Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial - Eur J Nutr. 2019 Feb 22 - "Subjects were randomized to be treated with indistinguishable tablets (2 per day, to be taken after dinner) containing 800 mg phytosomal curcumin (Curserin®: 200 mg curcumin, 120 mg phosphatidylserine, 480 mg phosphatidylcholine and 8 mg piperine from Piper nigrum L. dry extract) for 8 weeks ... After 56-day treatment, the curcumin-treated group experienced a significant improvement in fasting plasma insulin (FPI), HOMA index, waist circumference, blood pressure, triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index of liver steatosis and serum cortisol compared to the baseline. FPI, TG, liver transaminases, fatty liver index and serum cortisol level also significantly improved compared with the placebo-treated group. Compared to the baseline, at the end of the study placebo group experienced an improvement only in FPG and TG ... supplementation with a phytosomal preparation of curcumin containing phosphatidylserine and piperine could improve glycemic factors, hepatic function and serum cortisol levels in subjects with overweight and impaired fasting glucose" - [Nutra USA] - See curcumin products at Amazon.com, phosphatidylserine at Amazon.com, phosphatidylcholine at Amazon.com and piperine extract at Amazon.com.
  • Cannot sleep due to stress? Here is the cure - Science Daily, 9/5/17 - "Octacosanol reduced corticosterone level in blood plasma, which is a stress marker. The octacosanol-administered mice also showed normal sleep, which was previously disturbed due to stress. They therefore claim that the octacosanol mitigates stress in mice and restores stress-affected sleep to normal in mice. The sleep induced by octacosanol was similar to natural sleep and physiological in nature. However, authors also claimed that octacosanol does not affect sleep in normal animals. These results clearly demonstrated that octacosanol is an active compound that has potential to reduce stress and to increase sleep, and it could potentially be useful for the therapy of insomnia caused by stress" - See policosanol at Amazon.com.
  • A probiotic stress fix - Science Daily, 3/27/17 - "U.S. sailors and Marines face continuous periods of excessive stress in "fight-or-flight" situations, triggering surges of chemical messengers called neurotransmitters, often known as an adrenaline rush. While these surges are important for relaying messages in the brain, prolonged high levels can cause long-term health problems, including anxiety and susceptibility to infection ... Tae Seok Moon, an engineer in the School of Engineering & Applied Science at Washington University in St. Louis, is working to create a probiotic from a commercially-available, beneficial bacterial strain of Escherichia coli after receiving a three-year, $508,635 grant from the Office of Naval Research's 2017 Young Investigator Program ... We tend to think the gut and the brain are separate, but recently, more researchers think they are connected through the microbiota-gut-brain axis" - See probiotic products at Amazon.com.  Note:  It sounds like the military has finally figured out that high stress increases cortisol.  I was an army helicopter pilot in Vietnam for 17 months then an aircraft carrier jet pilot in the navy.  My cortisol was through the roof for years after I retired.  Military endocrinologists basically told be "tough, now get lost".
  • Supplementation with macular carotenoids reduces psychological stress, serum cortisol, and sub-optimal symptoms of physical and emotional health in young adults - Nutr Neurosci. 2017 Feb 15:1-11 - "Oxidative stress and systemic inflammation are the root cause of several deleterious effects of chronic psychological stress. We hypothesize that the antioxidant and anti-inflammatory capabilities of the macular carotenoids (MCs) lutein, zeaxanthin, and meso-zeaxanthin could, via daily supplementation, provide a dietary means of benefit ... Supplementation with the MCs significantly reduces stress, cortisol, and symptoms of sub-optimal emotional and physical health" - See carotenoids supplement at Amazon.com.
  • Clinical Study Shows AstaReal(R) Astaxanthin Effective in Reducing both Mental and Physical Fatigue - yonhapnews.co.kr, 11/7/16 - "AstaReal® astaxanthin significantly reduced perceived symptoms of mental and physical fatigue compared to the placebo. These included improvements in clarity of thinking, concentration, motivation, and mood. Irritation and feeling of body heaviness were reduced. In the calculation test, an increase in errors observed in the placebo during the second half of the test was almost eliminated in the astaxanthin group. Supplementation with astaxanthin also significantly reduced salivary cortisol, a biomarker for stress" - [Nutra USA] - See astaxanthin at Amazon.com.
  • Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial - J Evid Based Complementary Altern Med. 2016 Apr 6 - "A total of 52 subjects under chronic stress received either Ashwagandha (300 mg) or placebo twice daily. Primary efficacy measures were Perceived Stress Scale and Food Cravings Questionnaire. Secondary efficacy measures were Oxford Happiness Questionnaire, Three-Factor Eating Questionnaire, serum cortisol, body weight, and body mass index. Each subject was assessed at the start and at 4 and 8 weeks. The treatment with Ashwagandha resulted in significant improvements in primary and secondary measures. Also, the extract was found to be safe and tolerable. The outcome of this study suggests that Ashwagandha root extract can be used for body weight management in adults under chronic stress" - [Nutra USA] - See Ashwagandha at Amazon.com.
  • Vitamin D pill a day may improve exercise performance and lower risk of heart disease - Science Daily, 11/1/15 - "Previous studies suggest that vitamin D can block the action of enzyme 11-βHSD1, which is needed to make the "stress hormone" cortisol. High levels of cortisol may raise blood pressure by restricting arteries, narrowing blood vessels and stimulating the kidneys to retain water. As Vitamin D may reduce circulating levels of cortisol, it could theoretically improve exercise performance and lower cardiovascular risk factors ... gave 13 healthy adults matched by age and weight 50μg of vitamin D per day or a placebo over a period of two weeks ... Adults supplementing with vitamin D had lower blood pressure compared to those given a placebo, as well as having lower levels of the stress hormone cortisol in their urine. A fitness test found that the group taking vitamin D could cycle 6.5km in 20 minutes, compared to just 5km at the start of the experiment. Despite cycling 30% further in the same time, the group taking vitamin D supplements also showed lower signs of physical exertion" - See vitamin D at Amazon.com.
  • DHA Supplements May Reduce Stress in Pregnant Women - Medscape, 11/7/14 - "The reduction in cortisol output may improve the uterine environment for the developing fetus ... Researchers randomly assigned the women to receive either 450 mg of DHA per day or a placebo ... At 30 weeks of pregnancy, perceived stress was significantly lower among participants supplementing with DHA compared with among women receiving the placebo (P = .029). In addition, cortisol output in response to a stressful situation was 20% lower in the women who received the supplement than in the placebo group ... high levels of psychological and environmental stress during pregnancy are linked to developmental problems in children, including increased anxiety, difficulty paying attention, and impaired learning" - See docosahexaenoic acid at Amazon.com.
  • A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study - Lipids Health Dis. 2014 Jul 31;13(1):121 - "randomly allocated to one of three study arms (placebo, PAS 200 and PAS 400 per day, respectively) ... Compared to placebo, a supplementation with a daily dose of PAS 400 was effective in normalizing the ACTH (p = 0.010), salivary (p = 0.043) and serum cortisol responses (p = 0.035) to the TSST in chronically high but not in low stressed subjects (all p > 0.05). Compared to placebo, supplementation with PAS 200 did not result in any significant differences in these variables" - See phosphatidylserine at Amazon.com.
  • Oxytocin promotes social behavior in infant rhesus monkeys - Science Daily, 4/28/14 - " In another test, the researchers found that after exposure to oxytocin, monkeys had lower levels of cortisol in their saliva. Cortisol is produced by the adrenal glands in response to stress. Lower cortisol levels after oxytocin exposure indicate that oxytocin may also function to diminish anxiety" - See Oxy Pro (Oxytocin) Nasal Spray at International Anti-aging Systems.
  • Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats - Behav Brain Res. 2014 Feb 3 - "Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in specific brain proteins ... The present study attempts to explore the mechanisms underlying the antidepressant-like action of resveratrol by measuring serum corticosterone levels and the content of brain derived neurotrophic factor (BDNF) in the hippocampus and amygdala of rats exposed to the chronic unpredictable mild stress (CUMS). Male Wistar rats were subjected to the CUMS protocol for a period of 5 weeks to induce depressive-like behavior. Resveratrol treatment (20, 40 and 80mg/kg/i.p. 5 weeks) significantly reversed the CUMS-induced behavioral abnormalities (reduced sucrose preference, increased immobility time and decreased locomotor activity) and the elevated serum corticosterone levels observed in stressed rats. Additionally, five-weeks of CUMS exposure significantly decreased BDNF levels in the hippocampus and amygdala, and was accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB), while resveratrol treatment normalized these levels. All of these effects of resveratrol were essentially identical to that observed with the established antidepressant, desipramine" - Note: "decreased ... the elevated serum corticosterone levels".  That might mean it lowers cortisol.  See resveratrol products at Amazon.com.
  • Probiotics a Potential Treatment for Mental Illness - Medscape, 11/19/13 - "although human studies are still largely lacking, they did find some with promising results on behavior, including 1 showing that healthy volunteers who received Lactobacillus helveticus R0052 plus B longum for 30 days reported significantly lower stress levels than those who received placebo, as well as significantly reduced urinary free cortisol levels ... Another study of 124 volunteers (mean age, 61.8 years) showed that those who consumed probiotic-containing yogurt for 3 weeks had significantly improved mood compared with those who received placebo ... the term "psychobiotic" was created as recent studies have begun to explore a possible link between probiotics and behavior ... As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid [GABA] and serotonin, which act on the brain-gut axis ... a study of human patients with chronic fatigue syndrome showed that those who consumed an active strain of L casei 3 times a day had significantly higher improvement scores on anxiety measures than did those who received matching placebo" - See probiotic products at Amazon.com.
  • Effects of Soy, Whey Protein Supplementation Post-Exercise - Science Daily, 10/12/13 - "Our main findings demonstrate that 14 days of supplementation with soy protein does appear to partially blunt serum testosterone. In addition, whey influences the response of cortisol following an acute bout of resistance exercise by blunting its increase during recovery"
  • Effect of Magnolia officinalis and Phellodendron amurense (Relora(R)) on cortisol and psychological mood state in moderately stressed subjects - J Int Soc Sports Nutr. 2013 Aug 7;10(1):37 - "Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense) barks are medicinal plants commonly used as traditional remedies for reducing stress and anxiety ... assessed salivary cortisol exposure and psychological mood state in 56 subjects (35 men and 21 women) screened for moderate stress and supplemented with a standardized/patented MP combination (Relora(R), Next Pharmaceuticals) or Placebo for 4 weeks ... After 4 weeks of supplementation, salivary cortisol exposure was significantly (p<0.05) lower (-18%) in the Relora group compared to Placebo. Compared to Placebo, the Relora group had significantly better (p<0.05) mood state parameters, including lower indices of Overall Stress (-11%), Tension (-13%), Depression (-20%), Anger (-42%), Fatigue (-31%), and Confusion (-27%), and higher indices of Global Mood State (+11%) and Vigor (+18%)" - Note: The biggest affect was on anger (-42%).  See Relora at Amazon.com.
  • Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo-controlled trial in abstinent alcoholics - Mol Nutr Food Res. 2013 Feb 6 - "Behavioral distress and dysfunctions of hypothalamic-pituitary-adrenocortical (HPA) axis play a central role in alcohol abuse. Omega-3 fatty acids are proposed as having antistress, regulatory effects on HPA responsiveness ... doubleblind, placebo-controlled trial was performed in male alcoholics undergoing residential rehabilitation program, to evaluate the effects of 3-week supplementation with fish-oil providing eicosapentaenoic (60 mg/day) and docosahexaenoic acid (252 mg/day) on perceived stress/anxiety and HPA activity, assessed by measuring saliva basal cortisol levels at various daytimes ... In conclusion, an elevated omega-3 intake may reduce distress symptoms and basal cortisol secretion in abstinent alcoholics, thus providing a valid subsidiary measure to increase the efficacy of rehabilitation programs in ethanol addicts" - Note:  I'm wondering why they chose such a low dose.  That's not even the amount of omega-3 in the average capsule on one good fish oil capsule.  See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Oxytocin, Social Sharing and Recovery from Trauma - Science Daily, 12/18/12 - "'social sharing of emotions' (SSE) ... SSE, like the neuropeptide oxytocin (OT) -- known variously as 'the hug hormone', 'the moral molecule' and 'the natural love drug' -- has a calming and bonding function in humans. So a team of researchers decided to examine whether it followed that administering oxytocin might ease this therapeutic and powerful 'social sharing of emotions' ... What they found was that OT did not make people more talkative -- the word counts in the letters were the same -- but it did increase the participants' willingness to share the specific component that is responsible for the therapeutic effects of social sharing: emotions. As the researchers note, "the findings are the more remarkable because they were obtained among men, who may be less inclined than women to express their emotions." ... there may be further implications for human health, related to OT's antagonistic effect on the stress hormone cortisol" - See Oxytocin Factor or Oxy Pro (Oxytocin) Nasal Spray at International Anti-aging Systems.
  • Nutrient in eggs and meat may influence gene expression from infancy to adulthood - Science Daily, 9/20/12 - "Consuming greater amounts of choline -- a nutrient found in eggs and meat -- during pregnancy may lower an infant's vulnerability to stress-related illnesses, such as mental health disturbances, and chronic conditions, like hypertension, later in life ... More choline in the mother's diet led to a more stable HPA axis and consequently less cortisol in the fetus ... Pressman joined a team led by Marie Caudill, Ph.D., R.D., professor in the Division of Nutritional Sciences at Cornell, in studying 26 pregnant women in their third trimester who were assigned to take 480 mg of choline per day, an amount slightly above the standard recommendation of 450 mg per day, or about double that amount, 930 mg per day. The choline was derived from the diet and from supplements and was consumed up until delivery" - See citicholine at Amazon.com.
  • Ginseng May Banish Cancer Fatigue, New Study Finds - ABC News, 6/4/12 - "Some studies have shown that ginseng decreases inflammation and the stress hormone cortisol, both of which may be contributing factors to cancer-related fatigue" - See ginseng at Amazon.com.
  • Rhodiola rosea: Nature’s anti-depressant - Fox News, 3/7/12 - "Many studies support what even the ancient Chinese emperors knew - that Rhodiola rosea gives a terrific lift to body and mind. In one study of people with stress-related fatigue conducted in Sweden, the Rhodiola exerted an anti-fatigue effect, increased mental performance, decreased the stress hormone cortisol in the blood, and reduced stress overall ... In another study reported in The Journal of Alternative and Complementary Medicine, Rhodiola rosea caused improvement in patients with generalized anxiety disorder. Yet another study of depressed people in Armenia showed significant improvement in overall mood as a result of taking Rhodiola rosea extract" - See Rhodiola rosea at Amazon.com.
  • Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism - Biochem Biophys Res Commun. 2011 Dec 7 - "Results suggest that resveratrol can prevent glucocorticoid-induced muscle wasting and that this effect is at least in part SIRT1-dependent" - Note:  I think what they are saying is that resveratrol may help prevent muscle loss due to high cortisol.  Stress increases cortisol.  Exercise may be partially defeating as far as muscle tone in that it increases cortisol.  That's just my theory.  See resveratrol products at Amazon.com.
  • Omega-3 supplements show benefits against anxiety: Human data - Nutra USA, 9/14/11 - "the Ohio State researchers recruited 68 medical students to participate in their parallel group, placebo-controlled, double-blind trial. The med students were given either placebo capsules or omega-3 capsules containing 2085 mg of EPA (eicosapentaenoic acid) and 348 mg DHA (docosahexanoic acid) ... Results showed a 14% reduction in levels of the production of pro-inflammatory interleukin 6 (IL-6), as well as a 20% reduction in anxiety symptoms in the omega-3 group, compared to the placebo group ... Proinflammatory cytokines promote secretion of corticotropin-releasing hormone (CRH), a primary gateway to hormonal stress responses; CRH also stimulates the amygdala, a key brain region for fear and anxiety. Accordingly, alterations in inflammation could also influence anxiety" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.  Note:  CRH increases cortisol.  See:
  • Grapefruit juice and liquorice increase cortisol availability in patients with Addison's disease - Eur J Endocrinol. 2011 Sep 6 - "Compared to the ordinary treatment, the median AUC for serum cortisol increased with liquorice (53783 vs. 50882, p<0.05) and GFJ (60661 vs. 50882, p<0.05). Cortisol levels in serum were also elevated 2.6h after tablet ingestion (liquorice 223 vs. 186 nmol/L, p<0.05; GFJ 337 vs. 186 nmol/L, p<0.01). Liquorice increased the median urinary cortisol/cortisone-ratio (0.43 vs 0.21, p<0.00001), whereas GFJ increased the (aTHF+THF)/THE-ratio (0.55 vs 0.43, p<0.05)" - Note:  From my readings, most have too much cortisol already.  I've read where licorice increases it.  Licorice and grapefruit juice sounds like an unlikely combination but people might want to be aware of it.
  • Preventive Action of Panax ginseng Roots in Hypercortisolism-induced Impairment of Hippocampal Neurons in Male C57BL/6N Mice - Phytother Res. 2011 Aug;25(8):1242-5 - "An increasing number of people suffering from hypercortisolism are at risk of developing hippocampus impairment and mental disorders. The aim of this study was to investigate whether the water extract of Panax ginseng roots (GWE) could prevent hypercortisolism-induced adverse consequences. Hypercortisolism was experimentally induced by repeated corticosterone injection in male mice. Treatment with corticosterone alone resulted in a significant decrease in hippocampus neurofilament light chain (NF-L) protein expression and induced depression-like behavior. Serum corticosterone was significantly increased in the corticosterone-treated mice. Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced or partially antagonized the effects induced by corticosterone toward the normal values of the controls; however, it failed to normalize increased corticosterone levels in corticosterone-treated mice. Overall, ginseng conclusively exhibited a protective action against hypercortisolism-induced impairment of hippocampal neurons" - See ginseng at Amazon.com.
  • Vitamin A Decreases Pre-receptor Amplification of Glucocorticoids in Obesity: Study on the Effect of Vitamin A on 11beta-Hydroxysteroid Dehydrogenase Type 1 Activity in Liver and Visceral Fat of WNIN/Ob Obese Rats - Nutr J. 2011 Jun 23;10(1):70 - "11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of inactive glucocorticoids to active glucocorticoids and its inhibition ameliorates obesity and metabolic syndrome. So far, no studies have reported the effect of dietary vitamin A on 11beta-HSD1 activity in visceral fat and liver under normal and obese conditions. Here, we studied the effect of chronic feeding of vitamin A-enriched diet (129mg/kg diet) on 11beta-HSD1 activity in liver and visceral fat of WNIN/Ob lean and obese rats ... Control groups received stock diet containing 2.6mg vitamin A/kg diet, where as experimental groups received diet containing 129mg vitamin A/Kg diet for 20 weeks ... Vitamin A supplementation significantly decreased body weight, visceral fat mass and 11beta-HSD1 activity in visceral fat of WNIN/Ob obese rats. Hepatic 11beta-HSD1 activity and gene expression were significantly reduced by vitamin A supplementation in both the phenotypes. CCAAT/enhancer binding protein alpha(C/EBPalpha), the main transcription factor essential for the expression of 11beta-HSD1, decreased in liver by vitamin A fed-obese rats, but not in lean rats. Liver X receptor alpha (LXR alpha), a nuclear transcription factor which is known to downregulate 11beta-HSD1 gene expression was significantly increased by vitamin A supplementation in both the phenotypes" - Note:  See my 11beta-HSD1 page.  11beta-HSD1 goes hand in hand with cortisol.
  • Fish Oil Lowers Cortisol and Body Fat Levels - Vital Choice, 12/13/10 - "Black tea is shown to rapidly normalize cortisol levels after stress ... Fish oil has also been found to improve body composition in preliminary clinical studies … an outcome attributed to various physiological effects of omega-3s ... In tests performed at the end of the six-week study, members of the fish oil group showed significantly lower cortisol levels" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects - Br J Nutr. 2010 Oct 26:1-9 - "In the preclinical study, rats were daily administered PF for 2 weeks and subsequently tested in the conditioned defensive burying test, a screening model for anti-anxiety agents. In the clinical trial, volunteers participated in a double-blind, placebo-controlled, randomised parallel group study with PF administered for 30 d and assessed with the Hopkins Symptom Checklist (HSCL-90), the Hospital Anxiety and Depression Scale (HADS), the Perceived Stress Scale, the Coping Checklist (CCL) and 24 h urinary free cortisol (UFC). Daily subchronic administration of PF significantly reduced anxiety-like behaviour in rats (P < 0.05) and alleviated psychological distress in volunteers, as measured particularly by the HSCL-90 scale (global severity index, P < 0.05; somatisation, P < 0.05; depression, P < 0.05; and anger-hostility, P < 0.05), the HADS (HADS global score, P < 0.05; and HADS-anxiety, P < 0.06), and by the CCL (problem solving, P < 0.05) and the UFC level (P < 0.05). L. helveticus R0052 and B. longum R0175 taken in combination display anxiolytic-like activity in rats and beneficial psychological effects in healthy human volunteers" - Note, in case you missed it, it's saying that it also reduced cortisol. See probiotics at Amazon.com.
  • Dietary fatty acid composition alters 11beta-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue - Lipids Health Dis. 2010 Oct 8;9(1):111 - "The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) amplifies intracellular glucocorticoid action by converting inactive glucocorticoids to their active forms in vivo. Adipose-specific overexpression of 11beta-HSD1 induces metabolic syndrome in mice, whereas 11beta-HSD1 null mice are resistant to it. Dietary trans and saturated fatty acids (TFAs and SFAs) are involved in the development of metabolic syndrome, whereas polyunsaturated fatty acids (PUFA) offer protection against this. Here, we report the effects of chronic feeding of different diets containing vanaspati (TFA rich), palm oil (SFA rich) and sunflower oil (PUFA rich) at 10%level on 11beta-HSD1 gene expression in rat retroperitoneal adipose tissue. 11beta-HSD1 gene expression was significantly higher in TFA rich diet-fed rats compared to SFA rich diet-fed rats, which in turn was significantly higher than PUFA rich diet-fed rats. Similar trend was observed in the expression of CCAAT-enhancer binding protein-alpha (C/EBP-alpha), the main transcription factor required for the expression of 11beta-HSD1. We propose that TFAs and SFAs increase local amplification of glucocorticoid action in adipose tissue by upregulating 11beta-HSD1 by altering C/EBP--gene expression. The increased levels of glucocorticoids in adipose tissue may lead to development of obesity and insulin resistance, thereby increasing the risk of developing metabolic syndrome" - Note:  11beta-HSD1 goes hand in hand with cortisol.
  • Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice - Br J Pharmacol. 2010 Sep;161(1):113-26 - "11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome. Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple biological activities ... Emodin is a potent and selective 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively. Single oral administration of emodin inhibited 11beta-HSD1 activity of liver and fat significantly in mice. Emodin reversed prednisone-induced insulin resistance in mice, whereas it did not affect dexamethasone-induced insulin resistance, which confirmed its inhibitory effect on 11beta-HSD1 in vivo. In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism, and lowered blood glucose and hepatic PEPCK, and glucose-6-phosphatase mRNA. CONCLUSIONS AND IMPLICATIONS This study demonstrated a new role for emodin as a potent and selective inhibitor of 11beta-HSD1 and its beneficial effects on metabolic disorders in DIO mice. This highlights the potential value of analogues of emodin as a new class of compounds for the treatment of metabolic syndrome or type 2 diabetes" - Note:  (11beta-HSD1) goes hand in hand with cortisol.  It seems like what came first, the chicken or the egg.  I googled emodin and didn't see any reliable places that sold it.  One article said that it was in some resveratrol products and that the emodin was what caused the stomach problems.
  • Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans - Biomed Res. 2007 Apr;28(2):85-90 - "the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects"
  • Black Tea Soothes Away Stress - Science Daily, 10/4/06 - "the study participants – who drank a black tea concoction four times a day for six weeks – were found to have lower levels of the stress hormone cortisol in their blood after a stressful event, compared with a control group who drank the fake or placebo tea for the same period of time"
  • Cortisol, Stress, and Health - Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3 fatty acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ... Rhodiola rosea: 100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day, standardized extract ... DHEA: 25-50 mg/day (any hormone supplementation should be monitored by your physician)"
  • Can You Slim Down with Cortisol Blockers? - Dr. Weil, 10/7/04
  • A botanical to beat 'stress-eaters' - Nutra USA, 4/15/04 - "Relora appears to promote weight maintenance and decrease stress arousal as demonstrated by decreased evening cortisol and decreased systolic blood pressure" - See iHerb Relora products.
  • Is Stress Making You Fat? - Dr. Weil, 1/16/04 - "In addition to the link to weight gain, elevated cortisol levels can have adverse effects on the immune system, memory, and sugar metabolism ... women with a high waist-to-hip ratio, whether they were overweight or slim, secreted more cortisol under stress and also reported more stress in their daily lives than women with low waist-to-hip ratios ... caffeine can elevate levels of cortisol"
  • Alterations in Stress Cortisol Reactivity in Depressed Preschoolers Relative to Psychiatric and No-Disorder Comparison Groups - Archives of General Psychiatry, 12/03 - "the first investigation of HPA axis reactivity in very young children with a clinical depressive syndrome ... Depressed preschoolers displayed a pattern of increasing cortisol levels throughout the assessment in response to both separation and frustration stressors"
  • Low-Dose DHEA Increases Androgen, Estrogen Levels in Menopause - Medscape, 12/12/03 - "Cortisol F plasma levels progressively decreased throughout the study. Both groups also experienced significantly reduced LH and FSH plasma levels"
  • Stress-Busting Help Comes From Hormone - WebMD, 8/2/04 - "The people who reported fewer symptoms and who performed best at their military tasks had "significantly higher" levels of the hormone DHEA-S compared with cortisol" [Abstract] - See iHerb DHEA products.
  • Exercise Boosts Physical/Mental Health in Diabetics, Breast Cancer Patients, Healthy Males - Doctor's Guide, 6/22/01 - "Researchers found minimal decreases in glucose levels when exercise occurred in the morning, afternoon or evening hours, but found dramatic decreases when subjects exercised at night. Increases in levels of the hormones cortisol and thyrotropin were greater in the evening and night."
  • It is Never Too Late to Regenerate Your Brain - Life Extension Magazine, 6/01 - "Lower your stress, lower your cortisol levels and it is likely that your brain can regenerate its powers to learn and remember"
  • Stress: The Hidden Factor For Weight Gain - Nutrition Science News, 4/01 - "Under stress, the body excretes corticotrophin-releasing hormone and adrenalin. This reaction stimulates the release of cortisol from the adrenal cortex. In turn, cortisol, a glucocorticoid, stimulates glucose release into the bloodstream, which, during periods of chronic stress, creates an excessive release of insulin. Insulin, which is part of the endocrine system, is a fat-storage hormone that overrides the stress signal from adrenalin to burn fat. The excess release of insulin gives the body the message to store fat in the abdomen"
  • Clinical Trial Update: STGI Announces Anticort's FDA Phase I/II is Moving Forward - Business Wire, 7/28/99 (same article as above dead link)
  • Sports Science - An Answer To Intense Training - Health & Nutrition Breakthroughs, 7/98 - "The research team found that, compared to placebo, the plasma cortisol response to exercise was about 16 percent lower for the 400 mg dose of PS and 30 percent lower for the 800 mg dose."
  • Anti-Cortisols May Offer New Hope For Retinitis Pigmentosa - Doctor's Guide, 11/17/97 - "According to Sapse, RP can be treated initially with a cocktail of anti-cortisol nutritional compounds including vitamin A, zinc, ginkgo biloba and acetyl-L-carnitine . . ."
  • Findings Show Cortisol's Major Role in AIDS and Other Diseases - Doctor's Guide, 6/21/96 - "Anticort, (to lower cortisol) a high dose form of stabilized procaine HCL, is being successfully tested in pilot clinical studies in Brazil and the U.S., in HIV+ and AIDS populations ... Researchers have already started to explore the therapeutic benefits of such an approach through the use of anti-cortisol drugs, such as RU-486, DHEA, Ketaconazole, Anticort and Tianeptine"
  • Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. II. Relation to suicide, psychosis, and depressive symptoms - Arch Gen Psychiatry 1984 Apr;41(4):379-87 - "Serum cortisol levels were significantly higher after administration of 5-hydroxytryptophan (5-HTP), 200 mg orally"
  • Study 20 - The Hypericum Homepage - "Both serum-cortisol and serum-prolactin were lowered significantly after three weeks of treatment with hypericum extract in male rats."

Other News:

  • FDA Approves Levoketoconazole for Cushing Syndrome - Medscape, 1/4/22 - "Levoketoconazole inhibits cortisol synthesis. The FDA approval was based on efficacy and safety data from two phase 3 studies involving a total of 166 patients with endogenous Cushing syndrome. In both the open-label, single-arm SONICS study and the randomized, placebo-controlled LOGICS trial, the drug significantly reduced and normalized mean urinary free cortisol levels and improved several secondary endpoints ... The most common adverse reactions (occurring in > 20%) include nausea/vomiting, hypokalemia, hemorrhage/contusion, systemic hypertension, headache, hepatic injury, abnormal uterine bleeding, erythema, fatigue, abdominal pain/dyspepsia, arthritis, upper respiratory infection, myalgia, arrhythmia, back pain, insomnia/sleep disturbances, and peripheral edema"
  • Elevated stress hormones linked to higher risk of high blood pressure and heart events - Science Daily, 9/13/21 - "Adults with normal blood pressure and high levels of stress hormones were more likely to develop high blood pressure and experience cardiovascular events compared to those who had lower stress hormone levels ... Studies have shown that cumulative exposure to daily stressors and exposure to traumatic stress can increase cardiovascular disease risk. A growing body of research refers to the mind-heart-body connection, which suggests a person's mind can positively or negatively affect cardiovascular health, cardiovascular risk factors and risk for cardiovascular disease events, as well as cardiovascular prognosis over time ... Norepinephrine, epinephrine and dopamine are molecules known as catecholamines that maintain stability throughout the autonomic nervous system -- the system that regulates involuntary body functions such as heart rate, blood pressure and breathing. Cortisol is a steroid hormone released when one experiences stress and is regulated by the hypothalamic-pituitary-adrenal axis, which modulates stress response ... Over a median of 6.5-year follow-up period, every time the levels of the four stress hormones doubled was associated with a 21-31% increase in the risk of developing hypertension ... During a median of 11.2-years of follow-up, there was a 90% increased risk of cardiovascular events with each doubling of cortisol levels. There was no association between cardiovascular events and catecholamines"
  • Keep your friends close, cortisol levels low for life - Science Daily, 6/30/21 - "Across both age groups, those working with familiar partners had consistently lower cortisol levels than those working with unfamiliar partners"
  • Mild Cortisol Excess Increases Mortality in Adrenal Incidentaloma - Medscape, 5/24/21 - "Researchers found a linear increase in mortality risk with increasing cortisol values up to 200 nmol/L (7.25 µg/dL) following DST ... Over 14 years, 16.2% (170 patients) died. Compared with cortisol less than 50 nmol/L (1.8 µg/dL) following DST, adjusted hazard ratios for mortality were 2.30 and 3.04 for cortisol levels 83 to 137 nmol/L (3-5 µg/dL) and 138 nmol/L (5 µg/dL) or greater, respectively, and both were significant ... Among the patients who died, causes of death were cardiovascular disease in 38%, cancer in 30%, infection in 4%, and other diseases in 28% ... Patients with post-DST cortisol levels of 83 nmol/L (3 µg/dL) or higher had increased cardiovascular mortality, while those with levels of 50-82 nmol/L (1.8-3.0 µg/dL) did not. In contrast, mortality rates from cancer, infection, and other diseases didn't vary across groups"
  • Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study - J Clin Endocrinol Metab 2021 Apr 5 - "While hypercortisolism may be associated with AF, this association has not yet been ascertained causally ... Evidence derived from the MR study suggests a positive association between plasma cortisol and risk of AF, likely mediated through SBP and WC"
  • First Approval for Osilodrostat for Cushing Syndrome, in EU - Medscape, 11/15/19 - "Osilodrostat is an oral cortisol synthesis inhibitor that specifically works to control or normalize elevated cortisol levels by inhibiting 11β-hydroxylase, an enzyme responsible for the final step of cortisol biosynthesis in the adrenal gland ... Its mechanism of action is similar to that of metyrapone, an older Cushing's drug, but osilodrostat has a longer plasma half-life and is more potent against 11β-hydroxylase"
  • Cortisol in Hair May Help Diagnose Teen Depression - Medscape, 8/8/19 - "These results, when graphed, showed a u-shaped curve. Hair cortisol levels on the lower and higher end of the distribution predicted depressive symptoms in a diverse sample of youth"
  • Stress hormones promote breast cancer metastasis - Science Daily, 3/13/19 - "Concentrations of the stress hormones cortisol and corticosterone were higher in mice with metastases that in those with no metastases. The scientists show that increased levels of these stress hormones activate the GR, which cause increased colonization and heterogeneity of the cancer cells -- and ultimately, shortened survival"
  • Biotin supplements caused misleading test results, almost led to unnecessary procedure - Science Daily, 5/18/18 - "The patient in the case report took a 5000 mcg dose of biotin daily ... In this patient's case, "The negative clinical impact included weeks of psychological distress concerning the possibilities of hypercortisolemia or a testosterone-producing tumor. Most significantly, these abnormal test results nearly resulted in an unnecessary invasive procedure for a complex patient with a hypercoagulable state," the case report says. Hypercortisolemia is a condition involving a prolonged excess of cortisol -- a steroid hormone -- in blood"
  • Cortisol excess hits natural DNA process and mental health hard - Science Daily, 3/28/17 - "High concentrations of the stress hormone, Cortisol, in the body affect important DNA processes and increase the risk of long-term psychological consequences ... The condition is characterized by abdominal obesity, fat deposits in the face and neck, high blood pressure and diabetes. To a high extent, the affected individuals also risk suffering from chronic fatigue syndrome, anxiety, depression and cognitive impairment ... Even if the physical symptoms improve after an operation on the tumor, our previous studies show that the psychiatric problems largely often persist. Some patients will never return to working life and may not even venture out into society for everyday activities"
  • PTSD risk can be predicted by hormone levels prior to deployment, study says - Science Daily, 3/7/17 - "Seminal research in the 1980s connected abnormal cortisol levels to an increased risk for PTSD, but three decades of subsequent research produced a mixed bag of findings, dampening enthusiasm for the role of cortisol as a primary cause of PTSD ... However, new findings published in the journal Psychoneuroendocrinology point to cortisol's critical role in the emergence of PTSD, but only when levels of testosterone -- one of most important of the male sex hormones -- are suppressed ... Prior attempts to link PTSD to cortisol may have failed because the powerful effect that testosterone has on the hormonal regulation of stress was not taken into account ... Before deployment, soldiers' stress responses were tested in a stressful CO2 inhalation challenge. "Healthy stress responses showed a strong cortisol increase in response to the stressor, whereas abnormal stress responses showed a blunted, nonresponsive change in cortisol ... soldiers who had an abnormal cortisol response to the CO2 inhalation challenge were more likely to develop PTSD from war-zone stress. However, soldiers who had an elevated testosterone response to the CO2 inhalation challenge were not likely to develop PTSD, regardless of the soldiers' cortisol response"
  • Stress Can Make the Pounds Accumulate - NYT, 3/1/17 - "After controlling for age, sex, ethnicity, smoking, diabetes and other factors that might be linked to obesity, they found that the higher the level of cortisol, the greater the body weight, B.M.I. and waist circumference. Higher cortisol levels were also associated with persistence of obesity over time"
  • Stress hormone measured in hair linked to persistent obesity, study finds - ABC News, 2/23/17 - "Scientists found those who had higher hair cortisol levels had a tendency to be larger and weigh more. In general, they also had the largest waists, were the heaviest in weight and had the highest body mass indexes (BMI)" -  See my cortisol page for ways to reduce it.
  • For cops, exposure to stressful situations dysregulates cortisol pattern - Science Daily, 2/6/17 - "If you experience chronic stress or high stress situations, the cortisol can no longer adjust normally like this. So what happens with people under a lot of stress, the cortisol flattens out. For some people it goes down and others it goes up and stays up. That's called the dysregulation of the HPA axis"
  • Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus - J Clin Endocrinol Metab. 2016 Jul 26 - "Metformin increases whole body cortisol generation by 11βHSD1 probably through an indirect mechanism, potentially offsetting other metabolic benefits of metformin"
  • Why exercise may not help obese shed much weight: Exercise can elevate stress response and make it more difficult to become slim - Science Daily, 5/12/14 - "The research covered 17 inactive people with a body mass index greater than 35 who took part in a 22 week programme for lifestyle change which involved exercise, diet and seminars ... Despite their efforts, the participants lost less weight than expected from the amount of keep-fit they did and the changes they made to their eating habits ... The scientists believe this could be related to cortisol ... those participants who lost the most weight had the lowest level of morning cortisol"
  • Saliva Test May Spot Depression Risk in Male Teens - WebMD, 2/20/14 - "boys with high levels of a stress hormone called cortisol were 14 times more likely to be diagnosed with clinical depression later ... Girls with high cortisol levels were only four times more likely to receive such a diagnosis ... This is the emergence of a new way of looking at mental illness"
  • Exposure to Cortisol-Like Medications Before Birth May Contribute to Emotional Problems, Brain Changes - Science Daily, 10/31/13 - "cortisol-like drugs called glucocorticoids are administered frequently to women in preterm labor to accelerate their babies' lung maturation prior to birth ... excessive glucocorticoid levels may have effects on brain development, perhaps contributing to emotional problems later in life ... researchers then divided the children into two groups: those who were exposed to glucocorticoids prenatally and those who were not ... children with fetal glucocorticoid exposure showed significant cortical thinning, and a thinner cortex also predicted more emotional problems. In one particularly affected part of the brain, the rostral anterior cingulate cortex, it was 8-9% thinner among children exposed to glucocorticoids"
  • Efficacy of medical treatment in Cushing's disease: a systematic review - Clin Endocrinol (Oxf). 2013 Oct 1 - "Pasireotide was the only treatment to be assessed in a randomized trial and was supported by a 'moderate' level of evidence. Response rates with pasireotide from three prospective studies were 17-29%. The remaining medications were supported by a 'low' or 'very low' level of evidence. The highest response rates were reported in small retrospective studies of metyrapone (75%, one study) and mitotane (72%, one study). Response rates were 25-50% for cabergoline (four studies) and 45% for ketoconazole (one study). Among studies that included patients with other forms of Cushing's syndrome, response rates were 53-88% for ketoconazole (three studies), 70% for mitotane (one study), 57% for metyrapone (one study) and 38-60% for mifepristone. Again, all of these medications are supported by a 'low' level of evidence"
  • Plasma cortisol in Alzheimer's disease with or without depressive symptoms - Med Sci Monit. 2013 Aug 19;19:681-9 - "Cortisol is presumed to be a risk factor for stress- and age-related disorders, such as depressive disorder and Alzheimer's disease (AD) ... Plasma cortisol concentration was measured in 80 AD patients (35 of them with depressive symptoms), 27 elderly depressive patients without AD, and 37 elderly controls ... Compared to controls, a significant increase of mean plasma cortisol was found in AD patients but not in depressive patients. Plasma cortisol was positively correlated with cognitive impairment in AD patients. We confirmed a U-shaped association between plasma cortisol and major depression and a linear association between plasma cortisol and AD without depressive symptoms. Significantly increased relative risk of disease in people with high plasma cortisol was found for AD with depressive symptoms and for AD with mild dementia"
  • Hair Cortisol Reveals Stress, Predicts CVD in Seniors - Medscape, 4/23/13 - "We found a 2.7-times increased risk of cardiovascular disease in our participants in the highest hair cortisol quartile compared to participants in the lowest quartile"
  • Cortisone can increase risk of acute pancreatitis - Science Daily, 2/25/13 - "people treated with cortisone in tablet form ran a 70 per cent higher risk of developing acute pancreatitis"
  • Medical Treatment of Cushing's Disease - J Clin Endocrinol Metab. 2013 Jan 23 - "Medical therapy for CD can be classified into pituitary-directed, adrenal-blocking, and glucocorticoid receptor-antagonizing drugs. Recent studies demonstrate that somatostatin receptor subtype 5 (sst(5)) and dopamine receptor subtype 2 (D(2)) are frequently (co-)expressed by corticotroph adenomas. Pituitary-directed therapy with pasireotide and cabergoline, targeting sst(5) and D(2), respectively, is successful in approximately 25-30% of patients. Adrenal-blocking drugs can be effective by inhibiting steroidogenic enzyme activity. Finally, the glucocorticoid receptor antagonist mifepristone induces clinical and metabolic improvement in the majority of patients. Each drug can have important side effects that may impair long-term treatment. Generally, patients with moderate to severe hypercortisolism need combination therapy to normalize cortisol production"
  • Exercise Can Slow Onset of Alzheimer's Memory Loss: Scientists Identify Link - Science Daily, 1/25/13 - "the stress hormone CRF -- or corticotrophin-releasing factor -- may have a protective effect on the brain from the memory changes brought on by Alzheimer's disease ... CRF is most associated with producing stress and is found in high levels in people experiencing some forms of anxiety and depressive diseases. Normal levels of CRF, however, are beneficial to the brain, keeping the mental faculties sharp and aiding the survival of nerve cells. Unsurprisingly then, studies have shown that people with Alzheimer's disease have a reduced level of CRF ... interrupting the hormone from binding on to the CRFR1 receptor blocked the improvement of memory normally promoted by exercise. However, in mice with Alzheimer's a repeated regime of moderate exercise restored the normal function of the CRF system allowing its memory enhancing effects. The results are in line with the idea that regular exercise is a means of improving one's ability to deal with everyday stress in addition to keeping mental abilities keen"
    • Corticotropin-releasing hormone - Wikipedia, the free encyclopedia - "Corticotropin-releasing hormone (CRH), originally named corticotropin-releasing factor (CRF)"

  • FDA Approves Pasireotide for Cushing's Disease - Medscape, 12/17/12 - "the US Food and Drug Administration has approved pasireotide diaspartate injection for the treatment of patients with Cushing's disease for whom surgery has been unsuccessful or who are not surgical candidates ... Pasireotide is administered twice daily ... a year-long double-blind phase 3 trial in which 162 patients were randomly assigned to receive either 600 or 900 μg subcutaneously delivered pasireotide twice daily ... Twelve (15%) participants in the lower-dose group and 21 (26%) of the higher-dosage group met the trial's primary endpoint (free urinary cortisol levels at or below the upper limit of normal with no dose increase at month 6) ... Although those success rates were relatively low, nearly 60% of 103 patients for whom urinary free cortisol levels were available at baseline and at 6 months had cortisol reductions of at least 50% ... nearly three quarters of the study participants experienced hyperglycemia-related adverse events, leading to 6% leaving the study and 46% requiring a new glucose-lowering medication"
  • Bodybuilding myth debunked: Growth-promoting hormones don't stimulate strength - Science Daily, 6/14/12 - "anabolic hormones -- long thought to be essential for building a muscular frame -- do not influence muscle protein synthesis, the process that leads to bigger muscles ... In the first study, researchers examined the responses of both male and female participants to intense leg exercise. Despite a 45-fold difference in testosterone increase, men and women were able to make new muscle protein at exactly the same rate ... In the second study ... The men experienced gains in muscle mass that ranged from virtually nothing to more than 12 pounds, yet their levels of testosterone and growth hormone after exercise showed no relationship to muscle growth or strength gain ... Surprisingly, the researchers noted that cortisol -- considered to have the opposite effect of anabolic hormones because it reduces protein synthesis and breaks down tissue -- was related to the gain in muscle mass" - Note:  That may be true about cortisol but looking at it another way, cortisol could be an indicator of how much you're working out.
  • Prevalence and associated factors of subclinical hypercortisolism in patients with resistant hypertension - J Hypertens. 2012 Mar 7 - "Patients with resistant hypertension had a relatively high prevalence of subclinical hypercortisolism, and its presence is associated with several markers of worse cardiovascular prognosis"
  • Cushing's Drug Benefits Some, but Has New Adverse Effects - Medscape, 3/7/12 - "Pasireotide normalized cortisol levels in 20% of patients with Cushing's disease who participated in a year-long phase 3 trial ... However, the drug also led to hyperglycemia-related adverse events in almost three quarters of the participants ... The median percentage change from baseline at 6 months was −47.9% (95% CI, −74.1% to −40.7%) in the low-dose group, and −47.9− (95% CI, −66.9% to −35.5%) in the 900-μg group. The median percentage change at 12 months in the low-dose group was −67.6% (95% CI, −72.7% to −42.4%) and −62.4% (95% CI, −78.7% to −38.5%) in the high-dose group"
  • A unique on-off switch for hormone production - Science Daily, 2/23/12
  • Does depression contribute to the aging process? - Science Daily, 2/21/12 - "telomere length was shorter in the depressed patients, which confirmed prior findings. Importantly, they also discovered that shorter telomere length was associated with a low cortisol state in both the depressed and healthy groups ... stress plays an important role in depression, as telomere length was especially shortened in patients exhibiting an overly sensitive HPA axis. This HPA axis response is something which has been linked to chronic stress and with poor ability to cope with stress" - Note:  I'm not sure if that's correct because depressed people usually have high cortisol, not low cortisol.  I read somewhere that PTSD was associated with low cortisol.
  • New Treatment for Cushing's Disease - Medscape, 1/23/12 - "Pasireotide is a somatostatin analogue that attaches to somatostatin receptors in the pituitary and block the release of adrenocorticotrophin. In clinical trials, pasireotide was shown to reduce the levels of cortisol in the urine by at least 50% in 41% of patients treated with a 900-μg dose, and in 34% of patients treated with a 600-μg dose"
  • Depression and chronic stress accelerates aging - Science Daily, 11/9/11 - "The telomere is the outermost part of the chromosome. With increasing age, telomeres shorten, and studies have shown that oxidative stress and inflammation accelerates this shortening. On this basis it has been suggested that telomere length is a measure of biological aging, and telomere length has subsequently been linked to age-related diseases, unhealthy lifestyle, and longevity. The research team shows that shorter telomere length is associated with both recurrent depression and cortisol levels indicative of exposure to chronic stress"
  • Stress hormones may increase cardiovascular risks for shift workers - Science Daily, 10/3/11 - "working in shifts leads to changes in long-term cortisol levels, suggesting that the stress hormone cortisol might be one of the factors contributing to the increased cardiovascular risks of shift workers ... In this study, researchers collected hair samples from 33 shift workers and 89 day workers"
  • Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients - Metabolism. 2011 Jun 23 - "11-β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol, mainly in the liver and visceral adipose tissue (VAT), and has been implicated in several metabolic disorders. The absence of systemic hypercortisolism in central obesity could be due to increased inactivation of cortisol to its tetrahydrometabolites by the hepatic enzymes 5α- and 5β-reductases ... Forty-one patients were recruited (age, 41.8 +/- 10.6 years; body mass index, 42.1 +/- 6.6 kg/m(2); 71% women). The expression of hepatic 5α- and 5β-reductases was positively correlated (r = +0.53, P = .004), and their expression levels were correlated with hepatic 11β-HSD1 expression (r = +0.61, P < .001 for 5α-reductase and r = +0.50, P < .001 for 5β-reductase). Hepatic 5α-reductase was associated with insulin (r = +0.34, P = .015). Visceral adipose tissue 11β-HSD1 expression was associated with glucose (r = +0.37, P = .025) and insulin (r = +0.54, P = .002). Our results showed that 5α-reductase and VAT 11β-HSD1 expressions were associated with insulinemia. These findings suggest that overexpression of 5α-reductase, through a higher inactivation of cortisol in the liver, could have a protective role in preserving hepatic sensitivity to insulin. The overexpression of liver reductases in obesity could be an adaptive response to an increase in cortisol production by the liver and visceral 11β-HSD1 to avoid systemic hypercortisolism"
  • New method to measure cortisol could lead to better understanding of development of common diseases - Science Daily, 5/2/11 - "Currently the standard method to measure cortisol levels is to take a blood or saliva sample. However, since cortisol is released in a circadian rhythm and with pulses throughout the day, levels can fluctuate considerably, meaning it is difficult to estimate an individual's long-term exposure to cortisol through blood and saliva tests alone ... hair cortisol levels correlated positively with waist to hip ratio (r=0.425, p=0.003) and waist circumference (r=0.392, p=0.007), meaning people with higher exposure to cortisol showed higher abdominal obesity ... measuring the amount of cortisol in hair can potentially be used to monitor a person's long-term exposure to cortisol"
  • Caffeinated Coffee Does Not Acutely Affect Energy Intake, Appetite, or Inflammation but Prevents Serum Cortisol Concentrations from Falling in Healthy Men - J Nutr. 2011 Feb 23 - "Our aim in this crossover study was to investigate the acute effects of caffeinated and decaffeinated coffee consumption on appetite feelings, energy intake, and appetite-, inflammation-, stress-, and glucose metabolism-related markers. Sixteen healthy men (age range, 21-39 y; BMI range, 19.7-28.6 kg/m(2)) received in a random order on 3 separate occasions a standard breakfast snack with 200 mL of either caffeinated coffee (3 mg caffeine/kg body weight), decaffeinated coffee, or water (control). Before intervention (-15 min) and at standard time points following breakfast consumption (0, 15, 30, 60, 90, 120, 150, and 180 min), participants recorded their appetite feelings and we collected blood samples for measurements of circulating glucose, insulin, cortisol, and appetite- and inflammation-related markers. At 180 min, participants consumed a meal ad libitum. The appetite-related ratings, the appetite plasma hormonal responses as well as the plasma glucose, serum insulin, and plasma and serum inflammatory marker responses did not show an overall intervention effect or a time x intervention interaction. Ad libitum energy intake did not differ among the 3 interventions. However, a significant intervention effect (P = 0.04) and a time x intervention interaction (P-interaction = 0.02) were found for serum cortisol; cortisol concentrations were significantly higher following the caffeinated coffee intervention, compared to control, at 60 min and thereafter. In conclusion, the usually consumed amount of caffeinated coffee does not have short-term effects on appetite, energy intake, glucose metabolism, and inflammatory markers, but it increases circulating cortisol concentrations in healthy men"
  • Association of Diurnal Patterns in Salivary Cortisol with All-Cause and Cardiovascular Mortality: Findings from the Whitehall II Study - J Clin Endocrinol Metab. 2011 Feb 23 - "We assessed all-cause, cardiovascular, and noncardiovascular death. Results: There were 139 deaths, 32 of which were deaths due to cardiovascular disease, during a mean follow-up period of 6.1 yr. Flatter slopes in cortisol decline across the day were associated with increased risk of all-cause mortality (hazard ratio for 1 sd reduction in slope steepness 1.30; 95% confidence interval (CI) = 1.09-1.55). This excess mortality risk was mainly driven by an increased risk of cardiovascular deaths (hazard ratio = 1.87; 95% confidence interval = 1.32-2.64). The association with cardiovascular deaths was independent of a wide range of covariates measured at the time of cortisol assessment. There was no association between morning cortisol, the cortisol awakening response, and mortality outcomes. Conclusions: These findings demonstrate, for the first time, the relationship between a flatter slope in cortisol levels across the day and an increased risk of cardiovascular disease mortality in a nonclinical population"
  • Simple spit and blood tests might detect burnout before it happens - Science Daily, 2/21/11 - "In addition to professional and personal suffering, burnout puts distressed workers at further risk of physical and psychological problems if ignored ... We hypothesized that healthy workers with chronic stress and with mild burnout symptoms would have worse physiological dysregulations and lower cortisol levels -- a profile consistent with burnout ... Cortisol is a stress hormone involved in our bodies stress response and naturally as part of our body's daily rhythm. Cortisol levels are often high in people suffering from depression, while it tends to be low in cases of burnout. Too much cortisol can be as bad as too little when it comes to both mental and physical health ... Critically, people with burnout are often treated with anti-depressant medications that lower cortisol levels. If cortisol is already lower than it should be, this course of treatment could represent a therapeutic mistake. "The use of an allostatic load index gives researchers and clinicians a window to see how chronic stress is straining the person"
  • Cortisol, dehydroepiandrosterone sulphate, their ratio and hypertension: evidence of associations in male veterans from the Vietnam Experience Study - J Hum Hypertens. 2011 Feb 10 - "Cortisol and the cortisol:DHEAS ratio were positively associated with hypertension (P<0.001), whereas DHEAS was negatively associated; the latter relationship was attenuated to non-significance (P=0.06) in models that adjusted for age, sociodemographics, place of service, health behaviours and BMI. The present analyses provide confirmation of a positive association between cortisol and the cortisol:DHEAS ratio and population hypertension"
  • Behavioral problems linked to cortisol levels: Study finds intervention needed as soon as behavioral problems appear - Science Daily, 2/9/11 - "Some youngsters with behavioral problems have abnormally high levels of cortisol, while others with identical problems have abnormally low levels ... Cortisol levels were abnormally high around the time problem behaviours began, but abnormally low when they had been present for a long time ... Problem behaviours were classified as either "internalizing" (depression and anxiety) or "externalizing" (aggression, attentional problems) ... Youngsters who developed depression-like symptoms or anxiety problems in adolescence had high levels of cortisol. However, those who developed symptoms earlier had abnormally low cortisol levels. The conclusion? Cortisol levels go up when individuals are first stressed by depression or anxiety, but then decline again if they experience stress for an extended period"
  • Why Women Feel Colder Than Men - CBS Chicago, 2/8/11 - "Women conserve more heat around their core organs, which means less heat circulates throughout the rest of their body ... It can often lead to a tug-of-war over the thermostat. That fight can get worse at night, when our bodies produce less cortisol ... cortisol is a very powerful hormone. It’s your fight hormone. So it keeps you warm, gets your adrenaline roaring and helps with body warming"
  • Persistent organic pollutants affect the stress hormone cortisol - Science Daily, 12/28/10 - "persistent organic pollutants (POPs), such as PCB and mixtures of different POPs, affect the way the adrenal cortex functions and thereby the synthesis of the stress hormone cortisol ... altered cortisol balance during early life may lead to a predisposition to develop several diseases in adulthood, such as diabetes and cardiovascular diseases"
  • Promising drug candidate reverses age-related memory loss in mice - Science Daily, 10/12/10 - "Such memory loss has been linked with high levels of 'stress' steroid hormones known as glucocorticoids which have a deleterious effect on the part of the brain that helps us to remember. An enzyme called 11beta-HSD1 is involved in making these hormones and has been shown to be more active in the brain during aging ... We found that life-long partial deficiency of 11beta-HSD1 prevented memory decline with aging. But we were very surprised to find that the blocking compound works quickly over a few days to improve memory in old mice suggesting it might be a good treatment for the already elderly ... We previously showed that carbenoxolone, an old drug that blocks multiple enzymes including 11beta-HSD1, improves memory in healthy elderly men and in patients with type 2 diabetes after just a month of treatment, so we are optimistic that our new compounds will be effective in humans. The next step is to conduct further studies with our preclinical candidate to prove that the compound is safe to take into clinical trials, hopefully within a year"
  • High stress hormone levels linked to increased cardiovascular mortality - Science Daily, 9/9/10 - "urinary cortisol did not increase the risk of non-cardiovascular mortality but did increase cardiovascular mortality risk. The third of the subjects with the highest urinary cortisol had a five-fold increased risk of dying of cardiovascular disease"
  • Chronic drinking increases levels of stress hormones, leading to neurotoxicity - Science Daily, 9/7/10 - "Both drinking and withdrawal from chronic drinking can raise circulating glucocorticoid levels, known as cortisol in humans and corticosterone in rodents. Prolonged and high concentrations of glucocorticoids can have damaging effects on neuronal function and cognition"
  • Hair provides proof of the link between chronic stress and heart attack - Science Daily, 9/3/10 - "Cortisol is considered to be a stress hormone. Its secretion is increased during times of stress. Traditionally it's been measured in serum, urine and saliva, but that only shows stress at the time of measurement, not over longer periods of time. Cortisol is also captured in the hair shaft"
  • Urinary Cortisol and Six-Year Risk of All-Cause and Cardiovascular Mortality - J Clin Endocrinol Metab. 2010 Aug 25 - "During a mean follow-up of 5.7 (SD = 1.2) yr, 183 persons died, of whom 41 died from cardiovascular disease. After adjustment for sociodemographics, health indicators, and baseline cardiovascular disease, urinary cortisol did not increase the risk of noncardiovascular mortality, but it did increase cardiovascular mortality risk. Persons in the highest tertile of urinary cortisol had a five times increased risk of dying of cardiovascular disease (hazard ratio = 5.00; 95% confidence interval = 2.02-12.37). This effect was found to be consistent across persons with and without cardiovascular disease at baseline"
  • Marriage and committed romance reduce stress-related hormone production - Science Daily, 8/17/10 - "We found that unpaired individuals of both sexes had higher cortisol levels than married individuals"
  • Cabergoline monotherapy in the long-term treatment of Cushing's disease - Eur J Endocrinol. 2010 Aug 11 - "Within 3-6 months, complete response was achieved in 11 patients (36.6%) and partial response in 4 (13.3%). After longer term therapy, 9 patients (30%) remain with a complete response after a mean of 37 months (range from 12-60 months) with a mean dose of 2.1 mg/wk of cabergoline. Two patients escaped after 2 and 5 years of complete response, but one transiently renormalized UFC after an increase in cabergoline dosage. No long-term response was maintained in 4 initial partial responders. Conclusions: Cabergoline monotherapy can provide an effective long-term medical therapy for selected patients with CD, but requires close follow-up for dose adjustments"
  • Link between depression, abdominal obesity confirmed by new study - Science Daily, 6/9/10 - "cortisol, a stress hormone, is related to depression and abdominal obesity. "So, there is reason to suspect that people who are depressed would have higher levels of abdominal obesity versus other parts of the body because of elevated cortisol,""
  • Partial restoration of GH responsiveness to ghrelin in Cushing's disease after 6 months of ketoconazole treatment: comparison with GHRP-6 and GHRH - Eur J Endocrinol. 2009 Aug 20
  • Stress Raises Belly Fat, Heart Risks - WebMD, 8/6/09 - "Even compared to other monkeys with the same body mass index and weight, CT scans showed that the stressed monkeys had a great deal more belly fat. And when the researchers looked at the animals' arteries, they found plaque clogging the arteries of the stressed monkeys ... it's not how much fat you have, but where it is located ... Over time, high cortisol levels cause belly fat to accumulate. It also makes individual fat cells get larger ... When you have lots more fat in visceral fat cells and all the characteristics of the metabolic syndrome, each of these things promotes atherosclerosis"
  • Symptoms Of Depression In Obese Children Linked To Elevated Cortisol - Science Daily, 6/11/09 - "There is evidence in adults that abnormal regulation of cortisol plays a role in both obesity and depression ... Cortisol levels in the saliva in the afternoon and evening correlated positively with symptoms of depression ... The more depressive symptoms that subjects reported, the higher the cortisol levels at those times"
  • Depression Raises Risk for Type 2 Diabetes - WebMD, 6/8/09 - "Depressed participants who were not being treated had significantly greater insulin resistance than study participants who were not depressed. But treatment for depression appeared to improve insulin sensitivity ... There are several theories about how depression may contribute to type 2 diabetes, but the most widely cited theory involves the stress hormone cortisol ... Cortisol is a key player in blood sugar metabolism and insulin sensitivity ... High cortisol levels are also associated with increased fat deposits around the abdomen, or belly fat, which is a risk factor for type 2 diabetes"
  • Asperger's Syndrome: Stress Hormone a Clue - Science Daily, 4/2/09
  • Work the Night Shift? Beware Diabetes - WebMD, 3/2/09 - "The 8.6 million Americans who work the night shift are at increased risk of obesity, diabetes, and heart disease. Why? ... much of the body's biological clock -- its circadian rhythm -- keeps day-shift time even when a person goes on the night shift ... Cortisol -- the so-called stress hormone that affects blood pressure and blood sugar -- rose and dropped at the wrong time"
  • Why some soldiers are cool under fire - MSNBC, 2/16/09 - "Blood samples taken from soldiers in the training programs showed those who fared best under extreme stress had lower levels of the stress hormone cortisol and higher levels of neuropeptide y, a chemical that dampens the body's stress response"
  • Symptoms Of Depression Associated With Increase In Abdominal Fat - Science Daily, 12/1/08 - "There are several mechanisms by which depression might increase abdominal fat, they note. Chronic stress and depression may activate certain brain areas and lead to increased levels of the hormone cortisol, which promotes the accumulation of visceral fat. Individuals with depression may have unhealthier lifestyles, including a poor diet, that could interact with other physiological factors to produce an increase in abdominal obesity" - Cortisol is like the chicken and the egg with depression.  They don't seem to know whether it is the cause or result.
  • Cushing's Syndrome Induced by Misuse of Moderate- to High-Potency Topical Corticosteroids (December) - Ann Pharmacother. 2008 Nov 18 - "Continuous use of moderate- to high-potency topical corticosteroids over several months can contribute to Cushing's syndrome"
  • Cortisol And Fatty Liver: Researchers Find Cause Of Severe Metabolic Disorders - Science Daily, 9/11/08 - "The researchers in Herzig's team specifically switched off the cortisol receptor in the livers of mice, thus blocking the hormone's effect. As a result, the triglyceride level in the livers of the experimental animals dropped considerably"
  • Effects of mirtazapine on dehydroepiandrosterone-sulfate and cortisol plasma concentrations in depressed patients - J Psychiatr Res. 2008 Aug 13 - "Mirtazapine significantly reduced both COR and DHEA-S concentrations, but had no impact on the COR/DHEA-S ratio"
  • Salivary cortisol is related to atherosclerosis of carotid arteries - J Clin Endocrinol Metab. 2008 Aug 5 - "area under the curve (AUC), which is a measure of total cortisol exposure while awake, and the slope, which is a measure of diurnal cortisol decline. Results: Total cortisol exposure while awake (AUC) was associated with higher plaque scores (beta = 0.08 per SD of AUC, 95% CI; 0.00 - 0.17, p-value = 0.04) in a fully adjusted linear regression model. Persons with an AUC in the highest tertile had a higher number of plaques of carotid arteries compared to those in the lowest tertile (3.08 versus 2.80 ... Our results support the hypothesis that increased total cortisol exposure is independently associated with atherosclerosis of the carotid arteries"
  • Stress Hormone Found To Regulate Brain Neurotransmission - Science Daily, 8/7/08 - "When we are subjected to a stress, our adrenal glands secrete hormones that affect our entire body. One of these hormones, cortisol, enables us to adapt physically and mentally to the stimulus. Following a major or repeated stress that the individual has no control over, however, cortisol is secreted in great quantities over a long period of time. This hypersecretion has damaging effects on the individual, to the point of accelerating aging and facilitating the onset of illnesses such as depression"
  • Depression can trigger diabetes, study suggests - MSNBC, 6/17/08 - "Depressed people were 42 percent more likely to develop diabetes ... depression also pushes up the levels of stress hormones such as cortisol ... Elevated cortisol levels can impair insulin sensitivity in the body and encourage belly fat, a risk factor for diabetes"
  • New Clue on Brain Problems and Diabetes - WebMD, 2/18/08 - "Too much of a stress-related hormone may be at the root of memory and other common brain-related diabetes complications ... increases in the stress hormone caused a drop in brain cell regeneration and a decline in memory formation in the rats. But normalizing the levels of the stress hormone reversed many of these negative effects and restored relatively normal brain function, regardless of changes in insulin production"
  • Stress Hormone Impacts Memory, Learning In Diabetic Rodents - Science Daily, 2/17/08 - "A new study in diabetic rodents finds that increased levels of a stress hormone produced by the adrenal gland disrupt the healthy functioning of the hippocampus, the region of the brain responsible for learning and short-term memory. Moreover, when levels of the adrenal glucocorticoid hormone corticosterone (also known as cortisol in humans) are returned to normal, the hippocampus recovers its ability to build new cells and regains the "plasticity" needed to compensate for injury and disease and adjust to change"
  • Patients With Mild Cushing Syndrome May Benefit From Adrenalectomy - Science Daily, 12/8/07 - "Diabetes and hypertension improved considerably in most affected patients after adrenalectomy. In addition, all eight patients who reported easy bruising before surgery noted resolution of the problem, and seven of the nine patients lost weight. Fat accumulation around the neck disappeared and muscle weakness improved, often markedly ... patients with subclinical Cushing syndrome rarely have enough cortisol in their urine to raise concern ... The cutoff values are intentionally set high so that we minimize the false positives"
  • Depression Associated With Low Bone Mineral Density - Medscape, 12/3/07 - "The novelty of this study is the fact that these women were not severely depressed ... Depression is considered a disease of chronic stress, Dr. Cizza said, with attendant increases in the stress hormone cortisol, and cytokines produced by the immune system. "Those substances are helpful to fight stress, but if there is too much cortisol or cytokines, there are side effects," he said. "One of the side effects is bone loss, so it was obvious to ask the question, 'do women with depression have low bone mass?'""
  • Feeling Stressed? How Your Skin, Hair And Nails Can Show It - Science Daily, 11/12/07 - "When a person becomes stressed, the level of the body’s stress hormone (cortisol) rises. This in turn causes an increase in oil production, which can lead to oily skin, acne and other related skin problems ... stress has a negative effect on the barrier function of the skin, resulting in water loss that inhibits the skin’s ability to repair itself after an injury"
  • Blood Pressure Drug Curbs Brain Damage From Alzheimer's, Depression And Schizophrenia - Science Daily, 11/6/07 - "Prazosin, also prescribed as an antipsychotic medication, appears to block the increase of steroid hormones known as glucocorticoids ... Scientists believe stress activates a neurochemical response in the brain that triggers the release of glucocorticoids in the brain, and that high levels of glucocorticoids in blood serum are associated with such psychiatric conditions as schizophrenia, depression, PTSD and Alzheimer's disease"
  • Relationship between cortisol and physical performance in older persons - Clin Endocrinol (Oxf). 2007 Jun 7 - "Physical performance is negatively associated with high cortisol levels in older persons"
  • Screening of Cushing's syndrome in adult patients with newly diagnosed diabetes mellitus - Clin Endocrinol (Oxf). 2007 Jun 4 - "unknown CS is not rare among patients with diabetes mellitus ... early diagnosis and treatment of CS may provide the opportunity to improve the prognosis of diabetes"
  • Low Cortisol Caused by Quetiapine - Doctor's Guide, 5/23/07 - "Quetiapine's 5-HT2 receptor blocking properties are thought to cause a strong inhibitory effect on ACTH and cortisol secretion" - Maybe Seroquel (quetiapine) might be way for people with high cortisol to reduce it but quetiapine has its own problems such as increased risk of diabetes and increased weight.
  • Relation of Cortisol Levels and Bone Mineral Density Among Premenopausal Women With Major Depression - Medscape, 5/4/07 - "a lower BMD and increased bone resorption were found in women with mild depression. Major depression had important effects on BMD and bone turnover markers. Depression should be considered among risk factors for osteoporosis in premenopausal women, therefore it may be useful to assess BMD values of MDD patients, and to treat them in cases of lower BMD values"
  • Scientists Unravel Clue In Cortisol Production - Science Daily, 4/24/07
  • Depression May Trigger Diabetes In Older Adults - Science Daily, 4/23/07 - "Carnethon theorizes that the culprit responsible for diabetes in persons who are depressed is a high level of a stress hormone, cortisol"
  • Salivary Cortisol Levels May Be a Biomarker for Late-Life GAD - Medscape, 3/6/07 - "The GAD group showed elevated basal levels compared with the control group. There was also a positive correlation between cortisol levels and severity of GAD"
  • Cortisol Secretion in Patients With Type 2 Diabetes: Relationship with chronic complications - Diabetes Care. 2007 Jan;30(1):83-8 - "the degree of cortisol secretion is related to the presence and number of diabetes complications"
  • Cortisol-cause and cure for metabolic syndrome? - Diabet Med. 2006 Dec;23(12):1281-8 - "reducing cortisol action may provide a novel therapeutic approach in the metabolic syndrome. There is substantial evidence that circulating cortisol concentrations are higher in people with hypertension and glucose intolerance ... Promising preclinical data suggest that novel 11beta-HSD1 inhibitors will have a role in lowering intracellular cortisol levels as a treatment for the metabolic syndrome"
  • Salivary Cortisol Response to Prednisolone Challenge Helps Understand Treatment-Resistant Depression - Doctor's Guide, 9/19/06 - "prednisolone is a better corticosteroid than dexamethasone to assess the HPA axis because it binds to 2 different receptors, not only the glucocorticoid receptors but also the mineralocorticoid receptors, providing a more physiological approach"
  • Reactions to Stress May Affect Brain Aging - Medscape, 8/14/06 - "the adrenal stress hormone cortisol appears to play an important role in mediating the effects of stress on the brain ... Although acute stress seems to enhance immune function and improve memory, chronic stress has the opposite effect and may even lead to disorders that become more prevalent with aging, such as depression, diabetes, and cognitive impairment"
  • Chronic Stress, Depression and Cortisol Levels Are Potential Risk Indicators for Periodontal Disease - Doctor's Guide, 5/31/06 - "being a caregiver to relatives with dementia, hypercortisolemia (overproduction of cortisol) or stress were associated with elevated plaque levels and increased gingival bleeding in a study that examined adults aged 50 years and older"
  • Antiglucocoticoid treatments for depression - Aust N Z J Psychiatry. 2006 May;40(5):402-5 - "Both preclinical and clinical studies report encouraging results which suggest that lowering circulating cortisol levels or blocking the effects of elevated cortisol with antagonists, which may up-regulate glucocorticoid receptors, has therapeutic benefits in terms of improvements in depressive symptoms and some domains of neurocognitive function"
  • Cortisol correlates with metabolic disturbances in a population study of type 2 diabetic patients - Eur J Endocrinol. 2006 Feb;154(2):325-31 - "The degree of severity of several clinical measures of type 2 diabetes correlates with cortisol concentrations. Moreover, the results provide evidence for a positive relationship between metabolic disturbances and cortisol concentrations that are within the accepted normal range"
  • Long-Term Stress May Shrink the Brain - WebMD, 5/20/05 - "Previous studies have already shown that stress hormones, such as cortisol, can increase the risk of heart disease and other ailments, but a new study shows that stress hormones may also shrink the brain"
  • Obesity and cortisol status - Horm Metab Res. 2005 Apr;37(4):193-7 - "Tissue hypercortisolism, due to increased intracellular activity of 11beta-HSD-1, which catalyzes reduction of cortisone to cortisol, has been reported in obese mice and humans"
  • Metyrapone May Be Effective as Additive Treatment of Major Depression - Medscape, 12/6/04 - "Alterations of the hypothalamic-pituitary-adrenal (HPA) axis are the most consistent pathological endocrine findings in depression"
    • Metyrapone - NetDoctor.co.uk - "Metyrapone works by stopping the natural production of a steroid hormone called cortisol"
  • Feds Sue Marketers Over Ads For Diet Pill - Intelihealth, 10/8/04
  • Dexamethasone Suppression Test Can Indicate Suicide Risk - Clinical Psychiatry News, 9/04 - "A positive DST at any point back then seems to indicate an increased suicide risk down the road"
  • Child’s Cortisol Level May Signal Depression Risk - Psychiatric News, 12/19/03 - "But even if individuals who were especially vulnerable to depression because of an abnormal cortisol response were identified, what could be done to keep them from developing depression? Using cognitive-behavioral therapy to teach them how to better deal with stress is one possibility, Feder said. Also, drugs are being developed to counter excessive cortisol secretion, and such drugs might likewise benefit individuals with this risk factor, she added"
  • Increased Cortisol Levels Linked to Decrease in Attention - Medscape, 8/11/03 - "Corticosteroids may be responsible for cognitive complaints symptoms in patients who take high doses of the medication chronically"
  • Steroid-Treated Patients Have High Risk of Cardiovascular Event - Doctor's Guide, 6/23/03
  • Schizophrenia Drugs Linked to Diabetes - WebMD, 6/3/03 - "close to 25% of them developed high blood sugar levels while taking Clozaril, the first of these newer schizophrenia medications -- called "atypical antipsychotics." ... people with schizophrenia have a four- to six-fold risk of diabetes compared with the general population ... One possible explanation: Those with schizophrenia typically have higher levels of cortisol, known as the "stress hormone," because the body releases it during times of agitation. And high cortisol levels can cause problems in the way blood sugar is metabolized"
  • Mirtazapine Attenuates Hypothalamic-pituitary-adrenocortical Axis Hyperactivity in Depressed Patients - Doctor's Guide, 4/17/03 - "it has been shown to have an acute inhibiting effect on cortisol secretion in healthy subjects ... Apparently, mirtazapine rapidly attenuates HPA axis hyperactivity in depressed patients via direct pharmaco-endocrinological effects. However, this amelioration of HPA system dysregulation is not necessarily related to clinical improvement" - Click here for a previous study.
  • New Stress-Buster Drugs Block Hormone Binding - Clinical Psychiatry News, 4/03 - "A new class of anxiety-relieving drugs—agents that interrupt core hypothalamic-pituitary-adrenal (HPA) stress signals—will emerge in the next 2-3 years ... In his HPA axis model of depression, the affected individual has a blunted ability to counterregulate in response to stress-induced cortisol increases, and thus is unable to turn off the fight-or-flight HPA mechanism. The result is constant anxiety and overreaction to external stimuli, followed by a sense of learned helplessness and loss of motivation. Many symptoms of deeply entrenched depressionanxiety, loss of appetite, reduced libido, elevated heart rate, hypertension, and dyslipidemia—point to HPA dysregulation ... People with melancholic depression do tend to produce abnormally high levels of CRH. These individuals also have elevated levels of cortisol"
  • Nighttime Salivary Cortisol Test Has Excellent Specificity and Sensitivity - Doctor's Guide, 4/7/03 - "Pseudo-Cushing's may result from obesity, depression, anxiety, poorly controlled diabetes, alcoholism, liver disease, or excessive exercise ... The salivary cortisol test had "100% specificity for ruling out pseudo-Cushing's," ... the test provides the opportunity for long-distance monitoring and follow-up. The patient can collect a sample and mail it to a laboratory for measurement"
  • Videoscopic Adrenalectomy Reduces Operative Trauma - Doctor's Guide, 4/3/03
  • Belly full of danger - USA Today, 2/25/03 - "people with wide girths are more likely to have large amounts of deep-hidden belly fat around their organs. It might be the most dangerous kind of fat and could increase a person's risk of diabetes, heart disease, stroke and some types of cancer ... visceral or intra-abdominal fat, is linked to high cholesterol, high insulin, high triglycerides, high blood pressure and other problems ... So far, physical activity and weight loss appear to be the key ... It's very likely that genes, sex hormones and stress hormones (cortisol) play a role"
  • How Your Mind Can Heal Your Body - Time Magazine, 1/20/03 - "More and more doctors—and patients—recognize that mental states and physical well-being are intimately connected. An unhealthy body can lead to an unhealthy mind, and an illness of the mind can trigger or worsen diseases in the body. Fixing a problem in one place, moreover, can often help the other ... Somehow depression makes the body less responsive to insulin, the hormone that processes blood sugar—plausibly through the action of cortisol, a hormone that can interfere with insulin sensitivity and that is often elevated in depressed patients ... Cortisol may also make depressed patients more prone to osteoporosis ... Cizza estimates that some 350,000 women get osteoporosis each year because of depression. Cortisol appears to interfere with the ability of the bones to absorb calcium and offset the natural calcium loss that comes with menopause and aging"
  • New Vistas in Antidepressant Development - Medscape, 11/21/02 - "The evidence for corticotropin-releasing factor (CRF) hypersecretion in depression and certain anxiety disorders is compelling ... CRF is transported to the anterior pituitary via the hypothalamo-hypophyseal portal system where it promotes the release of adrenocorticotropic hormone (ACTH) into the general circulation, which in turn stimulates the production and release of cortisol from the adrenal cortex ... Numerous studies have revealed that the direct injection of CRF into the CNS of laboratory animals produces effects reminiscent of the cardinal symptoms of depression, including decreased libido"
  • Ability To Cope With Stress May Play A Role In Cancer Progression - Intelihealth, 11/2/02 - "Studies have shown that people who adopt active coping strategies have better immune function and lower cortisol levels, and just the opposite for people who use passive coping strategies"
  • Chronic Stress And Metabolic Syndrome Linked - Doctor's Guide, 11/27/02 - "While the 24-hour cortisol metabolite and normetanephrine (three-methoxynorepinephrine) outputs were higher among cases than controls, HRV and total power were lower among cases" - Makes sense.  Stress increases cortisol, cortisol causes high blood sugar.  Also see my metabolic syndrome and stress pages. - Ben
  • Post-Adrenalectomy Radiosurgery Helpful In Adrenocorticotropic Hormone-Producing Pituitary Adenomas - Doctor's Guide, 11/13/02
  • Diabetes Drugs May Help Cushing's Syndrome - Reuters Wire, 11/07/2002 - "Cushing's syndrome results from high levels of the hormone cortisol, and can cause fat accumulation in the upper body and face, and thinning of the arms and legs. Patients can experience high blood pressure and high blood sugar, along with depression, fatigue, irritability and weakened bones ... a protein called PPAR-gamma, which is found on pituitary gland tumor cells, appears to be linked to overproduction of ACTH ... researchers injected mice with ACTH-secreting pituitary tumor cells and then treated them with commonly used diabetes drugs, rosiglitazone (Avandia) and troglitazone, or an inactive placebo ... There was an 85% reduction in ACTH and a corresponding 96% reduction in their cortisol-like hormone"
  • Exercise, Eating to Enhance Memory? - Dr. Weil, 9/26/02 - "Dr. Khalsa explains that in addition to age, chronic stress can harm the hippocampus via the release of high levels of the hormone cortisol from the adrenal gland"
  • Secondary Causes of Osteoporosis Higher in Fracture Patients - Doctor's Guide, 9/23/02 - "The most common cause of secondary osteoporosis is corticosteroid excess, whereas others include malignancy, gastric surgery, alcoholism, and anticonvulsant therapy use. Prior studies have shown that as many as 30 percent of postmenopausal women exposed to corticosteroids demonstrate causes of secondary osteoporosis"
  • Sertraline Effects Differ in Depressed Women - Doctor's Guide, 6/6/02 - "The investigators say four-week sertraline therapy increased plasma cortisol levels in the depressed patients"
  • Stress Hormone Behind Bad Skin - WebMD, 5/17/02 - "In response to stress, the brain signals production of several hormones. One of them is stress hormone, which makes the oil glands in the skin go into overdrive. Triggering of the stress system can also lead to hair loss, skin aging, and other skin problems" - I believe they are talking about cortisol.
  • Apolipoprotein E May Modulate Cortisol Production - Clinical Psychiatry News, 4/02 - "increased cortisol has been associated with a higher risk of a number of age-linked diseases, including diabetes mellitus, hypertension, and osteoporosis. In Alzheimer's disease, increased cortisol levels may lower the threshold for damage or death of hippocampal neurons"
  • Early to bed, kids better handle stress - USA Today, 3/14/02 - "Prolonged output of cortisol can: Raise blood pressure and heart rate. Weaken immune response, so that colds and other viruses take hold more easily. Make it harder to concentrate when challenged"
  • Managing Stress Key To Success - Intelihealth, 2/26/02 - "an overload of adrenaline and other stress hormones such as dopamine and cortisol can inhibit brain centers that control recollection of memory. That includes physical movements, from finding chords on the piano to skating triple flips"
  • Study: Women Cope Better With Stress - Intelihealth, 11/14/01 - "Men with higher levels of cortisol, a hormone produced during stress, recalled fewer words than males with lower levels"
  • The 'Language of Love' Good for Marriage -- and Health - WebMD, 8/28/01 - "positive interactions between couples can boost immunity and reduce the risk of heart disease by keeping stress hormones low ... language can affect cortisol levels ... women with cortisol increases were two to three times more likely to be divorced within 10 years"
  • Hormone Levels Could Spell D-I-V-O-R-C-E in Future - WebMD, 8/24/01 - "those who had the highest levels of three out of four key stress hormones during initial interviews were the most likely to be divorced 10 years later ... The hormones included epinephrine (better known as adrenalin, or the "fight-or-flight" hormone), norepinephrine, ACTH, and cortisol"
  • New Antidepressant Class May be On Its Way - Doctor's Guide, 8/9/01 - "A new class of antidepressants, which antagonize corticotropin releasing hormone 1 receptors, may be available soon"
  • Denial Speeds Progression To AIDS - Doctor's Guide, 4/2/01 - "The new study also linked higher average blood level of the stress hormone cortisol to speedier progression to AIDS"
  • Stress Linked to Functional Hypothalamic Amenorrhea - Doctor's Guide, 6/21/01 - "Increased levels of the stress hormone cortisol are clearly elevated in the bloodstream of child-bearing-aged women who have stopped menstruating"
  • Pattern of Corticotrophin-Releasing Hormone Increase Signifies Fetal Distress - Doctor's Guide, 6/21/01 - "The most plausible hypothesis is that stress leads to an increase in cortisol levels in the fetus and this then stimulates the placenta to make more CRH"
  • Frequent Flyer Beware: Jet Lag Is Bad for the Memory, Brain Cell and Memory Loss Related to Increased Stress Hormone - WebMD, 5/22/01 - "Over the long haul, Cho believes that elevated cortisol due to shifting time zones is responsible for both the loss of brain cells and the memory impairment. The higher the elevations in cortisol levels, the smaller the temporal lobe volumes on MRI"
  • Stressed Moms May Deliver Early - WebMD, 4/6/01 - "when traumatic or emotional situations occur, levels of the body's stress hormones, including cortisol, increase ... stressful events in the first few weeks of pregnancy may put them at risk for having a baby with birth defects of the face, lips, or heart"
  • How You React to Stress May Affect How Your Clothes Fit - WebMD, 1/16/01 - "fat created by cortisol is the "deep-belly" kind, which, one expert says, is known to increase health risks"
  • Denial Speeds Progression To AIDS - Doctor's Guide, 8/1/00 - "The new study also linked higher average blood level of the stress hormone cortisol to speedier progression to AIDS"
  • Neuroscience finds foggy link between depression and memory loss - CNN, 4/18/00 - "Studies show that prolonged depression or stress leads to elevated levels of cortisol, a "stress" hormone produced by the adrenal glands. This in turn appears to shrink or atrophy the hippocampus, the sea-horse shaped part of the brain associated with many kinds of memory and learning."
  • Why Are So Many Women Depressed? - Scientific America Women's Health: A Life Long Guide, Summer 1998 (see the subtopic "Stress and Cortisol") - "It is unclear whether depression is a cause or a consequence of elevated cortisol levels, but the two are undoubtedly related."
  • Study Supports Role Of Anticort In Treating Alzheimer's, HIV - Doctor's Guide, 4/17/98 - "Cortisol's role as a cause of disease is most recently confirmed in a study to be published in the May issue of the journal Nature Neuroscience. Authored by Dr. Sonia Lupien of McGill University, the study reports that high levels of cortisol play a key role in Alzheimer's, memory loss, shrinkage of the brain and aging. Dr. Lupien also states that such illnesses might be prevented with medications to reduce elevated cortisol levels."
  • Antifungal Drug May Be New Treatment For Chronic Kidney Disease - Doctor's Guide, 4/1/97 - "chronic kidney diseases progressed fastest in patients whose adrenal glands produced a large amount of cortisol, the body's principal steroid hormone, and slowest in patients whose adrenal glands produced little cortisol"
  • Anticort Aids Treatment - Doctor's Guide, 2/11/97
  • NIMH Links Depression to Bone Loss - Doctor's Guide, 10/16/96 - "Excess cortisol secretion, a common feature of some forms of depression, is known to cause bone loss"
  • Findings Show Cortisol's Major Role in AIDS and Other Diseases - Doctor's Guide, 6/21/96 - "Anticort, a high dose form of stabilized procaine HCL, is being successfully tested in pilot clinical studies in Brazil and the U.S., in HIV+ and AIDS populations."

Cushing's syndrome is caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. I've talked to doctors who implied that it was black and white, i.e. you have Cushing's or you don't.  My personal opinion, and I'm not a doctor, is that there is a linear gray area in between.

cushings.gif (8338 bytes)