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Home > Anti-aging Research > Deprenyl.

Deprenyl (Selegiline, Eldepryl, Emsam, etc.)

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  • Someone asked me about Alzheimer's. Personally, I'd be taking everything in the book to prevent or delay it. People have no idea the burden that puts on the family. An important item is selegiline. I've been taking it for decades for anti-aging.
    • Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group - J Psychiatry Neurosci. 1999 May; 24(3): 234–243 - "A total of 143 subjects completed enough of the trial to be entered in the analysis. Subjects were analyzed by 2 subgroups depending on whether they had a normal or pathologic result of the Clock Drawing Test. Analysis of variance showed significant improvement with selegiline versus placebo among those with a normal result of the Clock Drawing Test on the Mini Mental Status Examination (total score and orientation-place subscale) and among those with a pathologic result of the Clock Drawing Test of Sternberg's Memory Scanning test (for both speed and accuracy), on the Clinical Global Impressions scale as well as in terms of the dominant frequency on electroencephalograms. CONCLUSION: Selegiline has a long-term beneficial effect in Alzheimer's disease on memory modalities that reflect the function of the prefrontal areas of the brain, which are rich in dopamine receptors. The delayed appearance of differences between selegiline and placebo supports the notion that the mechanism of action is through neuronal rescue or neuroprotection. The differential response of patients with normal and pathologic results of the Clock Drawing Test may reflect the fact that the evaluation methods' sensitivity to change depends on the severity of dementia" - See selegiline at ReliableRXPharmacy.
  • Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats - Br J Pharmacol. 2018 Jul 3 - "Certain monoamine-oxidase (MAO) inhibitors have been shown to reduce body weight, although their effect on metabolic parameters have not been investigated. Here we assessed the effect of a widely used, selective MAO-B inhibitor, selegiline, on metabolic parameters in high-fat, high-sucrose diet-induced rat model of obesity ... Male Long-Evans rats were fed with control (CON) or high-fat (20%), high-sucrose (15%) diet (HFS) for 25 weeks. From week 16 groups of animals received subcutaneous injections of 0.25 mg kg-1 selegiline (CON+S and HFS+S) or vehicle (CON, HFS) once daily ,,, Selegiline decreased whole body fat, subcutaneous and visceral adiposity as measured by computer tomography and epididymal fat weight in the HFS group as compared to HFS placebo animals without influencing body weight. Oral glucose tolerance test and insulin tolerance test results showed impaired glucose homeostasis in HFS and HFS+S groups despite unchanged insulin levels in the blood plasma and pancreas. HFS induced expression of Srebp-1c, Glut1, and Mip1α in adipose tissue, which was alleviated by selegiline treatment ... These results suggest the potential benefit of selegiline to mitigate harmful effects of visceral adiposity" - See deprenyl (selegiline) at The Antiaging Store.  I've been taking 5 mg per day since Moby Dick was a minnow.
  • Selegiline transdermal system: a novel treatment option for major depressive disorder - Expert Opin Pharmacother. 2009 Jul;10(10):1665-73 - "Selegiline transdermal system is safe and effective in treating major depressive disorder at the dose range of 6 - 12 mg/24 h, without the need for dietary precautions at the 6 mg/24 h dose. No cases of hypertensive crisis were reported in clinical trials, even without dietary restrictions"
  • Transdermal Selegiline in Major Depression: A Double-Blind, Placebo-Controlled, Parallel-Group Study in Outpatients - Am J Psychiatry, 11/02 - "Transdermal selegiline (20 mg applied once daily by means of a 20-cm2 patch) administered for 6 weeks was an effective and well-tolerated treatment for adult outpatients with major depression. The typical side effects commonly seen with traditional monoamine oxidase inhibitor antidepressants were not observed"
  • MAO inhibitors and oxidant stress in aging brain tissue - Eur Neuropsychopharmacol. 1999 Mar;9(3):247-52 - "By reducing the oxidant stress observed in aging brain, MAO inhibitors, especially deprenyl, may contribute to the control of the aging process."
  • Current status of antioxidant therapy for Alzheimer's Disease - J Am Geriatr Soc. 1998 Dec;46(12):1566-72 - "High dose vitamin E, ginkgo biloba, and selegiline are three putative antioxidants that have been tested in randomized multicenter trial conditions in the US"
  • The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl - Mech Ageing Dev. 1988 Dec;46(1-3):237-62
  • Integrated medicine and the prevention and reversal of memory loss - Altern Ther Health Med. 1998 Nov;4(6):38-43 - "The program includes a diet consisting of 15% fat and supplementation with brain-specific nutrients such as vitamin B complex, vitamin E, ubiquinone, ginkgo biloba, and phosphatidylserine. In addition, stress-relieving meditation, mind-body and cognitive exercise, antiaging drugs like L-deprenyl citrate, as well as hormones such as dehydroepiandrosterone and pregnenolone complete the program"
  • Cortisol is higher in parkinsonism and associated with gait deficit - Acta Neurol Scand. 1998 Feb;97(2):77-85 - "Selegiline was associated with a lower cortisol"
  • Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors - Cancer Lett. 1998 Jan 30;123(2):177-83 - "These results suggest that the administration of deprenyl blocked the development of mammary tumors . . ."