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Home > Health Conditions > Esophageal Cancer

Esophageal Cancer

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  • Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality - J Natl Cancer Inst. 2012 Jan 23 - "Garlic and vitamin treatments were associated with non-statistically significant reductions in gastric cancer incidence and mortality. Vitamin treatment was associated with statistically significantly fewer deaths from gastric or esophageal cancer, a secondary endpoint (HR = 0.51, 95% CI = 0.30 to 0.87; P = .014)"
  • Meat Consumption, Cooking Methods, Mutagens, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay - Nutr Cancer. 2012 Jan 13 - "Red meat, lamb, and boiled meat were directly associated with the risk of ESCC, whereas total white meat, poultry, fish, and liver were mainly protective against this malignancy"
  • Macronutrients, vitamins and minerals intake and risk of esophageal squamous cell carcinoma: a case-control study in Iran - Nutr J. 2011 Dec 20;10(1):137 - "ESCC cases consumed significantly more hot foods and beverages and fried and barbecued meals, compared to the controls (p<0.05). After adjusting for potential confounders, the risk of ESCC increased significantly in the highest tertiles of saturated fat [OR:2.88,95%CI:1.15-3.08], cholesterol [OR:1.53, 95%CI: 1.41-4.13], discretionary calorie [OR:1.51, 95%CI: 1.06-3.84], sodium [OR:1.49,95%CI:1.12-2.89] and total fat intakes [OR:1.48, 95%CI:1.09-3.04]. In contrast, being in the highest tertile of carbohydrate, dietary fiber and (n-3) fatty acid intake reduced the ESCC risk by 78%, 71% and 68%, respectively. The most cancer-protective effect was observed for the combination of high folate and vitamin E intakes (OR: 0.02, 95%CI: 0.00-0.87; p<0.001). Controls consumed 623.5 times higher selenium, 5.48 times as much beta-carotene and 1.98 times as much alpha-tocopherol as the amount ESCC cases consumed"
  • Dietary patterns and risk of oesophageal cancers: a population-based case-control study - Br J Nutr. 2011 Sep 7:1-10 - "We conducted a population-based case-control study, which included 365 oesophageal adenocarcinoma (OAC), 426 oesophagogastric junction adenocarcinoma (OGJAC) and 303 oesophageal squamous cell carcinoma (OSCC) cases, with frequency matched on age, sex and geographical location to 1580 controls ... A high score on the meat-and-fat pattern was associated with increased risk of all three cancers: multivariable-adjusted OR 2.12 (95 % CI 1.30, 3.46) for OAC; 1.88 (95 % CI 1.21, 2.94) for OGJAC; 2.84 (95 % CI 1.67, 4.83) for OSCC (P-trend < 0.01 for all three cancers). A high score on the pasta-and-pizza pattern was inversely associated with OSCC risk (OR 0.58, 95 % CI 0.36, 0.96, P for trend = 0.009); and a high score on the fruit-and-vegetable pattern was associated with a borderline significant decreased risk of OGJAC (OR for Q4 v. Q1 0.66, 95 % CI 0.42, 1.04, P = 0.07) and significantly decreased risk of OSCC (OR 0.41, 95 % CI 0.24, 0.70, P for trend = 0.002). High-fat dairy foods appeared to play a dominant role in the association between the meat-and-fat pattern and risk of OAC and OGJAC"
  • Fruits and Vegetables Consumption and Esophageal Squamous Cell Carcinoma: A Case-Control Study - Nutr Cancer. 2011 May 24:1 - "A protective independent effect was observed for the highest tertile of total fruit consumption (OR: 0.13, CI: 0.04-0.45, P value = 0.001). Within the group of fruits, a significant inverse association was observed for bananas and kiwis (P for trends: 0.03 and 0.02, respectively). The risk of SCC decreased monotonically with increasing intake frequency of oranges (P value for trend = 0.01). The effect of total vegetable consumption on esophageal SCC was not significant, although a reduction in risk was observed in the highest tertile of intake (OR: 0.66, CI: 0.23-1.87, P value = 0.43). The results of the present study suggest a reasonable association between fruit consumption and esophageal SCC in a Middle Eastern high-risk population"
  • Strawberries may slow precancerous growth in the esophagus, study suggests - Science Daily, 4/6/11 - "freeze-dried strawberries significantly inhibited tumor development in the esophagus of rats ... daily consumption of strawberries suppressed various biomarkers involved in esophageal carcinogenesis, including cell proliferation, inflammation and gene transcription ... Each of the 36 study participants ate 60 grams (about two ounces) of freeze-dried strawberries daily for six months. The researchers obtained biopsy specimens before and after the strawberry consumption. The results showed that 29 out of 36 participants experienced a decrease in histological grade of the precancerous lesions during the study ... The survival rate of this type of esophageal cancer is very low, with only 10 percent of patients living 5 years after diagnosis"
  • Dietary Antioxidant and Mineral Intake in Humans Is Associated with Reduced Risk of Esophageal Adenocarcinoma but Not Reflux Esophagitis or Barrett' Esophagus - J Nutr. 2010 Aug 11 - "We found that overall antioxidant index, a measure of the combined intake of vitamin C, vitamin E, total carotenoids, and selenium, was associated with a reduced risk of EAC [odds ratio (OR) = 0.57; 95% CI = 0.33-0.98], but not BE (OR = 0.95; 95% CI = 0.53-1.71) or RE (OR = 1.60; 95% CI = 0.86-2.98), for those in the highest compared with lowest category of intake. Those in the highest category of vitamin C intake had a lower risk of EAC (OR = 0.37; 95% CI = 0.21-0.66; P-trend = 0.001) and RE (OR = 0.46; 95% CI = 0.24-0.90; P-trend = 0.03) compared with those in the lowest category. Vitamin C intake was not associated with BE, and intake of vitamin E, total carotenoids, zinc, copper, or selenium was not associated with EAC, BE, or RE. In conclusion, the overall antioxidant index was associated with a reduced risk of EAC. Higher dietary intake of vitamin C was associated with a reduced risk of EAC and RE. These results suggest that antioxidants may play a role in the pathogenesis of RE and EAC and may be more important in terms of progression rather than initiation of the disease process"
  • Curry compound kills cancer cells, study shows - MSNBC, 10/28/09 - "Researchers at the Cork Cancer Research Center in Ireland treated esophageal cancer cells with curcumin — a chemical found in the spice turmeric, which gives curries a distinctive yellow color — and found it started to kill cancer cells within 24 hours ... But these cells showed no evidence of suicide, and the addition of a molecule that inhibits caspases and stops this "switch being flicked' made no difference to the number of cells that died, suggesting curcumin attacked the cancer cells using an alternative cell signaling system" - See curcumin/turmeric products at iHerb.
  • Citrus fruit and cancer risk in a network of case-control studies - Cancer Causes Control. 2009 Oct 24 - "The ORs for the highest versus lowest category of citrus fruit consumption were 0.47 (95% confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI, 0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95% CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal cancer"
  • Effects of Dietary Fiber, Fats, and Meat Intakes on the Risk of Barrett's Esophagus - Nutr Cancer. 2009;61(5):607-16 - "Higher intakes of omega-3-fatty-acids [cases vs. population controls; OR = 0.46, 95% CI = 0.22-0.97, 4th vs. 1st quartiles of intake], polyunsaturated fat, total fiber (OR = 0.34, 95% CI = 0.15-0.76), and fiber from fruits and vegetables (OR = 0.47 95% CI = 0.25-0.88) were associated with a lower risk of Barrett's esophagus. Higher meat intakes were associated with a lower risk of long-segment Barrett's esophagus (OR = 0.25, 95% CI = 0.09-0.72). In contrast, higher trans-fat intakes were associated with increased risk (OR = 1.11; 95% CI = 1.03-1.21 per g/day). Total fat intake, barbecued foods, and fiber intake from sources other than fruits and vegetables were not associated with Barrett's esophagus"
  • Omega-3 Fatty Acids May Benefit Cancer Patients Undergoing Major Operations - Science Daily, 4/10/09 - "A randomised controlled trial showed omega-3 fatty acids given as part of an oral nutritional supplement resulted in the preservation of muscle mass in patients undergoing surgery for oesopahageal cancer, a procedure normally associated with significant weight loss and quality of life issues ... Patients given the standard supplement without omega 3 lost a significant amount of weight comprising 100% muscle mass. In fact 68% of patients suffered ‘clinically severe’ weight loss post surgery in the standard group (without omega 3) versus only 8% in the omega 3 group" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
  • Study: Drinking Too-Hot Tea May Raise Esophageal Cancer Risk - WebMD, 3/26/09 - "hot tea drinkers were twice as likely as warm or lukewarm tea drinkers to have esophageal cancer"
  • Wine May Cut Risk of Esophageal Cancer - WebMD, 3/2/09 - "Esophageal cancer rates have increased over the last three decades, due to a more than 500% increase of a subtype of the cancer linked to acid reflux disease, known as esophageal adenocarcinoma ... drinking as little as one glass of wine a day was associated with a 56% decrease in the risk for developing Barrett's esophagus ... About 5% of the U.S. population is estimated to have Barrett's, but most are never diagnosed. People with the condition have about a 30- to 40-fold higher risk of developing esophageal adenocarcinoma than the general population ... Wine is high in antioxidants and other studies have shown that people who eat plenty of antioxidant-rich fruits and vegetables are less likely to have Barrett's esophagus and esophageal cancer"
  • Chemopreventive Agents In Black Raspberries Identified - Science Daily, 1/8/09 - "anthocyanins, a class of flavonoids in black raspberries, inhibited growth and stimulated apoptosis in the esophagus of rats treated with an esophageal carcinogen" - [Nutra USA]
  • Plasma homocysteine, folate, and vitamin B12 levels in patients with laryngeal cancer - Arch Otolaryngol Head Neck Surg. 2008 Dec;134(12):1328-33 - "The mean (SD) level of total homocysteine in patients with laryngeal carcinoma was 2.84 (1.62) mg/L vs 0.99 (0.24) mg/L in the control group"
  • Green tea drinking, high tea temperature and esophageal cancer in high- and low-risk areas of Jiangsu Province, China: A population-based case-control study - Int J Cancer. 2008 Nov 6 - "Results showed that ever drinking green tea elevated OR in both counties (Dafeng OR = 1.2, 95% CI = 0.9-1.5; Ganyu: OR = 1.9, 95% CI = 1.4-2.4). Drinking tea at high temperature was found to increase cancer risk in both areas (Dafeng: OR = 1.9, 95% CI = 1.2-2.9; Ganyu OR = 3.1 95% CI = 2.2-4.3). However, after further adjustment for tea temperature, ever drinking tea was not related to cancer in either county (Dafeng: OR = 1.0, 95% CI = 0.7-1.3; Ganyu: OR = 1.3, 95% CI = 0.9-1.7). For dose-response relationships, we observed positive relationship with monthly consumption of tea (p for trend = 0.067) and tea concentration (p for trend = 0.006) after further adjustment for tea temperature. In conclusion, green tea drinking was not inversely associated with esophageal cancer in this study. However, drinking tea at high temperatures significantly increased esophageal cancer risk. There was no obvious difference of green tea drinking between low- and high-risk areas"
  • Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model - Int J Cancer. 2008 Oct 20 - "oxidative stress subsequent to gastroesophageal reflux is an important driving force of esophageal adenocarcinoma (EAC) formation in the esophagogastroduodenal anastomosis (EGDA) rat model. This study investigated the possible tumor inhibitory effects of 2 antioxidants, alpha-tocopherol (389 and 778 ppm), N-acetylcysteine (NAC, 500 and 1,000 ppm), and their combination (389 and 500 ppm, respectively), as well as an antacid therapeutic agent, omeprazole (1,400 ppm) ... alpha-Tocopherol dose-dependently decreased the incidence of EAC (p = 0.03), with 778 ppm alpha-tocopherol reducing the incidence of EAC to 59% (16/27) in comparison with 84% (26/31) in the control group (p = 0.04). Supplementation of alpha-tocopherol also increased the serum concentration of alpha-tocopherol. NAC at 500 and 1,000 ppm did not significantly decrease EAC incidence; however, the combination of alpha-tocopherol 389 ppm and NAC 500 ppm significantly reduced the incidence of EAC to 55% (15/27) (p = 0.02). alpha-Tocopherol alone or in combination with NAC significantly reduced the number of infiltrating cells positively stained for 4-hydroxynonenal. Omeprazole showed only a slight nonsignificant inhibitory effect at the dose given"
  • Black Raspberries Slow Cancer By Altering Hundreds Of Genes - Science Daily, 8/27/08 - "examined the effect of freeze-dried black raspberries on genes altered by a chemical carcinogen in an animal model of esophageal cancer ... The carcinogen affected the activity of some 2,200 genes in the animals’ esophagus in only one week, but 460 of those genes were restored to normal activity in animals that consumed freeze-dried black raspberry powder as part of their diet during the exposure"
  • (-)-Epigallocatechin-3-gallate (EGCG) inhibits HGF-induced invasion and metastasis in hypopharyngeal carcinoma cells - Cancer Lett. 2008 Jul 14 - "Hepatocyte growth factor (HGF) has recently attracted a considerable amount of attention as a stromal-derived mediator in tumor-stromal interactions, particularly because of its close involvement in cancer invasion and metastasis, and (-)-epigallocatechin-3-gallate (EGCG) can modulate the cell signaling associated with angiogenesis, metastasis, and migration of cancer cells ... EGCG at physiologically relevant concentration (1muM) suppressed HGF-induced tumor motility and MMP-9 and uPA activities, and the suppression of Akt and Erk pathway by EGCG was one of the downstream mechanisms to facilitate EGCG-induced anti-invasion effects. These results suggest that EGCG may serve as a therapeutic agent to inhibit HGF-induced invasion in hypopharyngeal carcinoma patients" - I took six capsules per day of green tea extract when I had my neck cancer.  Maybe that's what saved me.  See Jarrow green tea at iHerb.
  • Black Raspberries and Esophageal Cancer - Medscape, 12/10/07 - "Most important, 8-epiprostaglandin F2α (8-isoprostane) declined significantly after berry consumption (P < .05), with dramatic individual level declines occurring in 58% of the study patients" - See raspberry extracts at iHerb.
  • Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries - Int J Cancer. 2007 Jun 20 - "consumption of rancid butter, rancid sheep fat and preserved meat not spicy (mainly quaddid) were associated with significantly increased risk of NPC, while consumption of cooked vegetables and industrial preserved fish was associated with reduced risk. Other foods such as fresh citrus fruits and spicy preserved meat (mainly osban) in childhood, industrial made olive condiments in adulthood, were marginally associated. In multivariate analyses, only rancid butter, rancid sheep fat and cooked vegetables were significantly associated with NPC"
  • Fiber intake and risk of adenocarcinomas of the esophagus and stomach - Cancer Causes Control. 2007 Jun 12 - "Compared to subjects in the lowest quartile of fiber intake, subjects in the highest quartile of intake showed odd ratios of 0.44 (95% CI = 0.26-0.76) for esophageal adenocarcinoma (P trend = 0.004) and 0.58 (95% CI = 0.38-0.88) for gastric cardia adenocarcinoma ... High intake of fiber was associated with significant reduced risks of esophageal and gastric cardia adenocarcinoma"
  • Flavonoids and laryngeal cancer risk in Italy - Ann Oncol. 2007 Mar 19 - "Significant inverse relations were found for the highest versus the lowest quintile of intake for flavan-3-ols (OR = 0.64), flavanones (OR = 0.60), flavonols (OR = 0.32) and total flavonoids (OR = 0.60)"
  • Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay - Nutr Cancer. 2006;56(2):149-57 - "The odds ratio (OR) for high intake of linoleic acid was 1.4 (95% confidence interval, CI = 1.2-1.6), whereas lycopene displayed a strong protective effect (OR = 0.7; 95% CI = 0.6-0.9)" - Note:  Linoleic acid is an omega-6 oil found in most cooking oils like soy and corn oil.
  • Broccoli fights cancer-causing bacteria in humans - Nutra USA, 11/3/05
  • Zinc Deficiency Linked to Increased Risk of Less-Common Form of Esophageal Cancer - Doctor's Guide, 2/16/05 - "zinc deficiency in humans is associated with an increased risk of developing esophageal squamous cell carcinoma, an often-fatal form of esophageal cancer that has about 7,000 cases a year"
  • Selenium May Lower Risk Of Esophageal Cancer In People With Barrett's Esophagus - Intelihealth, 5/21/03 - "Higher serum selenium levels appear to be associated with a reduced risk of progression toward esophageal cancer among people with Barrett's esophagus"
  • Selenium May Inhibit Progression Toward Esophageal Cancer In Patients With Barrett's Esophagus - Doctor's Guide, 5/21/03
  • Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 - "Companies that manufacture selenium supplements will now be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers" - See iHerb and Vitacosticon selenium products.
  • Broccoli Beats Ulcers, Cancer - WebMD, 5/28/02
  • Nutrients May Influence Risk Of Stomach And Esophageal Cancer - Intelihealth, 11/8/01 - "patients who consumed high amounts of fiber, beta-carotene, folate, and vitamin C (found primarily in plant-based foods) were significantly less likely to develop cancer of the esophagus or stomach than those who consumed low amounts of these nutrients. Those who took vitamin C supplements were also less likely to develop certain types of stomach cancer. In contrast, those who consumed high amounts of foods of animal origin, including dietary cholesterol, animal protein, and vitamin B12, were significantly more likely to develop these cancers than those who consumed low amounts of such nutrients"
  • Hypericin May Be Potential Candidate For Treating Esophageal Cancer - Doctor's Guide, 5/22/01 - "Hypericin, the active ingredient in St. John’s Wort, a popular herbal remedy for depression, may be a potential candidate for treating esophageal and other tumors"

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