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Home > Health Conditions > Liver Cancer
prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell
proliferation and enhancing apoptosis - Mol Nutr Food Res. 2013 Oct 1 -
"Adult male Wistar rats were subjected to a two-phase
model of hepatocarcinogenesis (initiated-promoted group). Initiated-promoted
animals also received quercetin 10 and 20 mg/kg body weight (IPQ10 and IPQ20
groups, respectively). Antioxidant defenses were modified by quercetin
administration at both doses. However, only IPQ20 group showed a reduction in
number and volume of preneoplastic lesions. This group showed increased
apoptosis and a reduction in the proliferative index" - See
quercetin products at iHerb.
The Effect of Coffee
Consumption on the Development of HCC - Medscape, 8/12/13 -
"a high lifetime coffee consumption (≥20 000 cups) was
an independent protective factor against HCC, in each analyses using healthy and
risky control groups respectively (HCE group, OR 0.56, 95% CI 0.330.95; CLD
group, OR 0.55, 95% CI 0.360.85). However, the high coffee consumption did not
affect the HCC risk in patients with HBV (OR 0.64, 95% CI 0.361.14) after
adjustment for HBeAg status, serum HBV DNA level and antiviral therapy"
consumption delays the hepatitis and suppresses the inflammation related gene
expression in the Long-Evans Cinnamon rat - Clin Nutr. 2013 May 17 -
"Large-scale epidemiological studies have shown that
drinking more than two cups of coffee per day reduces the risks of hepatitis and
liver cancer ... Coffee administration for 25 weeks delayed the occurrence of
hepatitis by two weeks, significantly improved survival, reduced the expression
of inflammatory cytokines, and reduced the incidence of small pre-neoplastic
liver foci in LEC rats ... This study showed the efficacy of coffee in the
prevention of hepatitis and liver carcinogenesis in the LEC model"
Coffee Consumption and Risk
of Liver Cancer - Medscape, 4/22/13 - "searched
Medline, EMBASE, ISI Web of Science and the Cochrane library for studies
published up to May 2012 ... The summary odds ratio (OR) for high vs no/almost
never drinkers was 0.50 (95% confidence interval (CI): 0.420.59), with no
significant heterogeneity across studies (Q = 16.71; P = 0.337; I2 = 10.2%). The
ORs were 0.50 (95% CI: 0.400.63) for casecontrol studies and 0.48 (95% CI:
0.380.62) for cohort studies. The OR was 0.38 (95% CI: 0.250.56) in males and
0.60 (95% CI: 0.331.10) in females. The OR was 0.45 (95% CI: 0.360.56) in
Asian studies and 0.57 (95% CI: 0.440.75) in European studies. The OR was 0.39
(95% CI: 0.280.54) with no adjustment for a history of liver disease and 0.54
(95% CI: 0.460.66) after adjustment for a history of liver disease"
use linked to reduced hepatocellular carcinoma risk and mortality due to chronic
liver disease - Science Daily, 11/28/12 - "Hepatocellular
carcinoma (HCC), the most common type of primary liver cancer, occurs mainly
among patients with CLD ... performed an observational study of 300,504 men and
women aged 50 to 71 years enrolled in the National Institutes of Health-AARP
Diet and Health Study who reported their aspirin and nonaspirin NSAID use and
were followed-up for 10-12 years ... Study participants who used aspirin had a
41% reduced risk of HCC and a 45% reduced risk of death from CLD, whereas those
who used non-aspirin NSAIDs experienced a 26% reduced risk of CLD mortality but
no reduced risk of HCC" - [Abstract]
Metformin and reduced risk
of hepatocellular carcinoma in diabetic patients: a meta-analysis - Scand J
Gastroenterol. 2012 Nov 9 - "Medline and Embase
databases were searched to identify the relevant studies between January 1966
and December 2011 ... the overall prevalence of HCC was 3.40% (562/16,549) in DM
patients. The overall analysis showed a significantly reduced risk of HCC in
metformin users versus nonusers in diabetic patients (relative risk (RR) 0.24,
95% confidence interval (CI) 0.13-0.46, p < 0.001)" - See
metformin at IAS.
E may lower liver cancer risk - Science Daily, 7/17/12 -
"China who were enrolled in the Shanghai Women's Health
Study (SWHS) from 1997-2000 or the Shanghai Men's Health Study (SMHS) from
2002-2006, two population-based cohort studies jointly conducted by the Shanghai
Cancer Institute and Vanderbilt University. Using validated food-frequency
questionnaires, the researchers conducted in-person interviews to gather data on
study participants' dietary habits. They compared liver cancer risk among
participants who had high intake of vitamin E with those with low intake ...
Vitamin E intake from diet and vitamin E supplement use were both associated
with a lower risk of liver cancer. This association was consistent among
participants with and without self-reported liver disease or a family history of
liver cancer" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
Metformin for Liver Cancer
Prevention in Patients with Type 2 Diabetes: A Systematic Review and
Meta-Analysis - J Clin Endocrinol Metab. 2012 Apr 20 -
"In meta-analyses, metformin was associated with an
estimated 62% reduction in the risk of liver cancer among patients with type 2
diabetes ... When restricting the analysis to the four studies related to
hepatocellular carcinoma, metformin was again associated with a significantly
lower cancer risk (odds ratio 0.30, 95% confidence interval 0.17, 0.52; P <
0.001), and there was evidence of significant heterogeneity between these four
studies" - See
metformin at IAS.
Spectroscopic Characterization of Lycopene Extract from Lycopersicum esculentum
(Tomato) and Its Evaluation as a Chemopreventive Agent Against Experimental
Hepatocarcinogenesis in Mice - Phytother Res. 2012 May 25 -
"The present study was designed to characterize the
lycopene extract (LycT) prepared from tomatoes (Lycopersicum esculentum) and
then to evaluate its chemopreventive efficacy in N-diethylnitrosamine (NDEA)-induced
experimental hepatocarcinogenesis in female Balb/c mice ... In the animal study,
reduction in tumour incidence (42.05%), tumour burden (1.39) and tumour
multiplicity (3.42) was observed upon LycT pretreatment to NDEA-treated animals.
Histopathological analysis unravelled that the increased survival rate in LycT + NDEA-treated
animals was due to the delay in the formation of aggressive tumour nodules.
These observations indicate that lycopene seems to be an able candidate for
chemoprevention in hepatocarcinogenesis resulting from NDEA insults" -
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
Metformin may protect against liver cancer - Science Daily, 3/31/12 -
"chemically induced liver tumors in mice. The mice
taking metformin displayed minimal tumor activity, while the control mice
displayed significant tumor growth ... Girnun's team also showed that metformin
prevented liver cancer in part by inhibiting lipid synthesis in the liver, a
process known to promote cancer" - See
metformin at IAS.
consumption and reduced risk of hepatocellular carcinoma: findings from the
Singapore Chinese Health Study - Cancer Causes Control. 2011 Jan 22 -
"High levels of coffee or caffeine consumption were
associated with reduced risk of HCC (p for trend < 0.05). Compared with
non-drinkers of coffee, individuals who consumed three or more cups of coffee
per day experienced a statistically significant 44% reduction in risk of HCC
(hazard ratio 0.56, 95% confidence interval, 0.31-1.00, p = .049) after
adjustment for potential confounders and tea consumption"
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3
signalling pathway in human hepatocellular carcinoma: potential role as an
anti-proliferative, pro-apoptotic and chemosensitizing agent - Br J
Pharmacol. 2010 Dec 30 - "Overall, these results suggest
that γ-tocotrienol is a novel blocker of the STAT3 activation pathway, with a
potential role in future therapies for HCC and other cancers" - Note: The
γ symbol stands for gamma.
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at iHerb.
Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies
for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical
Trial - Anticancer Res. 2010 Dec;30(12):5145-5151 -
"arabinoxylan rice bran (MGN-3) in conjunction with an interventional therapy
(IT) for the treatment of hepatocellular carcinoma patients ... Patients in the
IT+MGN-3 group showed: (i) lower recurrence of the disease, 31.6% (12/38), as
compared to 46.7% (14/30) for the control; (ii) higher survival after the second
year, 35%, as compared to 6.7% for the control; (iii) significantly lower
alpha-fetoprotein level, a 38% decrease (p=0.0001), as compared to baseline
value, while the control showed no significant change; and (iv) a significant
decrease in tumor volume, in contrast to the control, which showed no
significant change. When the results were analyzed according to each IT
modality, MGN-3+IT sub-groups displayed a greater response to treatment, in
every aspect examined, than the IT sub-groups alone. However, the patients in
the MGN-3+TOCE+PEIT sub-group demonstrated greater reduction in AFP levels and
longer survival time than the MGN-3+TOCE sub-group" - See
arabinoxylan at iHerb.
decreases cholangiocarcinogenesis in hamsters by suppressing
inflammation-mediated molecular events related to multistep carcinogenesis -
Int J Cancer. 2010 Sep 7 - "Cholangiocarcinoma (CCA) is a highly metastatic
tumor linked to liver fluke infection and consumption of
nitrosamine-contaminated foods, and is a major health problem especially in
South-Eastern Asia ... Our results suggest that curcumin exhibits an
anticarcinogenic potential via suppression of various events involved in
multiple steps of carcinogenesis, which is accounted for by its ability to
suppress proinflammatory pathways" - See
curcumin/turmeric products at iHerb.
the liver: a potential treatment for liver disease? - Eur J Gastroenterol
Hepatol. 2010 Aug 26 - "Several studies consistently
show that coffee drinkers have a reduced risk of abnormal liver function tests,
cirrhosis and hepatocellular carcinoma. There is a clear dose response to this
Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation
associated with diet-induced obesity in mice - Biochem Pharmacol. 2009 Dec
1;78(11):1391-400 - "CoQ10 supplementation decreased the
global hepatic mRNA expression of inflammatory and metabolic stresses markers
without changing obesity and tissue lipid peroxides compared to HFF mice"
Jarrow Ubiquinol at iHerb.
consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study -
Cancer Causes Control. 2009 Sep 19 - "Over 9 years of
follow-up, among 325,947 accrued person-years, the total incidence of liver
cancer was 247 cases. We found that green tea consumption was inversely
associated with the incidence of liver cancer. In men, the multivariate-adjusted
HRs (95% CIs) for liver cancer incidence with different green tea consumption
categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53-1.30) for 1-2
cups/day, 1.11 (0.73-1.68) for 3-4 cups/day, and 0.63 (0.41-0.98) for >/=5
cups/day (p for trend = 0.11). The corresponding data among women were 1.00
(reference), 0.68 (0.35-1.31), 0.79 (0.44-1.44), 0.50 (0.27-0.90)" - See
Jarrow green tea extract at iHerb.
Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary Liver
Cancer In Rats - Science Daily, 7/30/09 - "A new
study investigated the effectiveness of S-adenosylmethionine (SAMe) in the
prevention and treatment of hepatocellular carcinoma (HCC) or primary liver
cancer. SAMe, a widely available nutritional supplement, with little known side
effects, was found to be effective in preventing the formation of HCC in rats"
- [Abstract] - See
SAM-e products at iHerb.
in the chemoprevention and treatment of hepatocellular carcinoma in a rat model
- Hepatology. 2009 Apr 6 - "SAMe is effective in
preventing HCC establishment but ineffective in treating established HCC because
of induction of hepatic methyltransferases, which prevents SAMe level to reach
high enough to kill liver cancer cells. SAMe's chemopreventive effect may be
related to its proapoptotic action and its ability to inhibit angiogenes"
SAM-e products at iHerb.
Protects against Ethanol-Induced Oxidative Stress in Rat Liver - J Agric
Food Chem. 2009 Jun 23 - "Red wine (RW) is rich in
polyphenolic antioxidants, often reported as hepatoprotective agents ...
Six-month-old Wistar rats were treated with RW or EtOH; controls were pair-fed.
EtOH increased 8-hydroxy-2'-deoxyguanosine and decreased reduced and oxidized
glutathione. These animals also displayed stimulated superoxide dismutase,
catalase, and glutathione reductase activities. RW treatment decreased
malondialdehyde and reduced glutathione levels. Glutathione-S-transferase and
selenium-dependent glutathione peroxidase activities were stimulated and
glutathione reductase activity was inhibited by RW intake. No modifications were
detected in nuclear factor-kappa B or alkaline phosphatase activities. EtOH
consumption induced fibrosis in portal spaces and hepatocyte lipid accumulation
that were absent with RW treatment. This paper highlights the importance of RW
nonalcoholic components and the relevance of biological matrix in the study of
EtOH oxidative effects"
lycopene and tomato extract supplementations inhibit nonalcoholic
steatohepatitis-promoted hepatocarcinogenesis in rats - Int J Cancer. 2009
Jun 23 - "Epidemiological and experimental studies
provide supportive evidence that lycopene (LY), a major carotenoid from tomatoes
and tomato products, may act as a chemopreventive agent against certain types of
cancers. We recently showed that high-fat diet (HFD)-induced nonalcoholic
steatohepatitis (NASH) promoted diethylnitrosamine (DEN)-initiated
hepatocarcinogenesis in a rat model ... tomato extract (TE) ... These data
indicate that LY and TE can inhibit NASH-promoted hepatocarcinogenesis mainly as
a result of reduced oxidative stress, which could be fulfilled through different
mechanisms" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
Suppresses Proliferation and Motility of Hepatocellular Carcinoma Cells by
Activating Steroid and Xenobiotic Receptor - Endocr J. 2009 Jun 24 -
"These results suggest that the activation of SXR could
contribute to tumor suppressive effects of vitamin K2 on HCC cells" - See
vitamin K products at iHerb.
Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by
Hepatitis Virus Infection Status - Cancer Epidemiol Biomarkers Prev. 2009
Jun;18(6):1746-1753 - "Compared with almost never
drinkers, increased coffee consumption was associated with a reduced risk of
liver cancer in all subjects (hazard ratio for <1, 1-2, and >/=3 cups/d;
P(trend) = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in
those with either or both HCV and HBV infection. In contrast, no association was
observed between green tea consumption and the risk of liver cancer in all
Coffee Consumption Associated With Lower Liver Cancer Risk - Science Daily,
6/26/08 - "0-1 cup, 2-3 cups, 4-5 cups, 6-7 cups, and 8
or more cups per day ... The researchers noted a significant inverse association
between coffee drinking and the risk of primary liver cancer. They found that
the multivariable hazards ratio of liver cancer dropped for each group that
drank more coffee. It fell from 1.00, to .66, to .44, to .38 to .32
Coffee May Curb Liver Cancer - WebMD, 8/2/07
Attempt to Evaluate the Effect of Vitamin K(3) Using as an Enhancer of
Anticancer Agents - Biol Pharm Bull. 2008;31(6):1270-1273 -
"These findings suggest that VK(3) induces G(2)/M arrest
by inhibition of cyclin B/cdk1 complex formation, and is thus useful as an
enhancer of G(2) phase-dependent drugs in hepatic cancer chemotherapy" -
vitamin K products at iHerb.
Flavonoid intake and liver cancer: a case-control study in Greece - Cancer
Causes Control. 2008 Mar 19 - "hepatocellular carcinoma
(HCC) ... Flavone intake, mostly derived from spinach and peppers, was inversely
associated with both virus positive (P-trend, 0.049) and virus negative
(P-trend, 0.084) HCC"
K(2) suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43
- Cancer Lett. 2008 Jan 29 - "The anti-cancer potential
of vitamin K(2) (VK(2)) in hepatoma has gained considerable attention" - See
vitamin K2 products at iHerb.
Scientific Evidence Of The Significant Anti-cancer Effect Of Milk Thistle -
Science Daily, 11/14/07 - "Their research results
indicate that silibinin can be used to prevent the development of liver cancer,
one of the most common cancers worldwide" - See
Silymarin products at iHerb.
Drinking Related To Reduced Risk Of Liver Cancer - Science Daily, 8/1/07 -
"hepatocellular carcinoma (HCC) ... The results showed a
41 percent reduction of HCC risk among coffee drinkers compared to those who
never drank coffee"
Folate may reduce liver damage study - Nutra USA, 7/6/07 -
"higher red blood cell folate levels were associated
with a 67 per cent reduced risk of liver cancer" - [Abstract]
folic acid products.
Blood folate levels and risk of liver damage and hepatocellular carcinoma in a
prospective high-risk cohort - Cancer Epidemiol Biomarkers Prev. 2007
Jun;16(6):1279-82 - "When comparing persons in the
lowest quartile RBC folate to persons in all other quartiles, the analysis found
that higher RBC folate levels were associated with reduced risk of
hepatocarcinogenesis (odds ratio, 0.33" - See
folic acid products.
Garlic compounds may stop liver cancer growth - Nutra USA, 5/4/06 -
"A one per cent solution of each garlic
extracts appeared to inhibit the growth of the tumour completely"
Omega-3s could stop liver cancer cells growth - Nutra USA, 4/3/06 -
"Both omega-3 fatty acids had a
dose-dependent inhibitory effect"
More evidence coffee may cut risk of liver cancer - Nutra USA, 8/4/05 -
"those who drink coffee occasionally
reduced their risk by almost 30 per cent, while those drinking one or more
cups a day had a risk of just 0.58 compared with the non-drinkers"
- Studies Examine Coffee Drinking And Risk Of Liver And Colorectal Cancers - Science Daily, 2/23/05 -
"People who drank coffee on a daily or almost daily basis had
about half the risk of HCC [hepatocellular carcinoma] compared with those who never drank coffee"
- Can Coffee Protect Against Common Cancers? - WebMD, 2/15/05 -
"Recent studies have shown that regular coffee consumption may lower the risk of developing
diseases such as diabetes and Parkinson's ... people who drank coffee every day or almost daily had about half the liver cancer risk as those who never drank coffee. The more coffee people drank the lower their risk"
Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver -
JAMA. 2004 Jul 21;292(3):358-61 - "Hepatocellular
carcinoma was detected in 2 of the 21 women given vitamin K2 and 9 of the 19 women in the control group ... the risk ratio for the development of hepatocellular carcinoma in patients given vitamin K2 was 0.13" - See
Vitamin K2 products at iHerb.
- Research Finds Tumor Preventive Qualities, Damage Reversal, In Green Tea - Intelihealth, 10/29/03 -
"At the same time, we see the value of green tea
polyphenols in reducing excretion of 8-OHdG. All of this is good news for the prevention and early detection of liver cancer" - See
green tea products.
- Adding Folates Alters Methotrexate Treatment In Rheumatoid Arthritics - Doctor's Guide, 4/21/03 -
"The researchers found the addition of
folates to MTX treatment was strongly linked with lack of hepatotoxicity" - See
iHerb folic acid products.
- Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 -
"Companies that manufacture selenium supplements will now
be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium
supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers" - See
iHerb selenium products.
- Wow, You Coulda Had Some Lycopene! - Cancer Decisions Newsletter , 1/7/03 -
"Lycopene may also help prevent liver cancer, according to findings from a
study presented at the American Association for Cancer Research meeting in October 2002. Hoyoku Nishino, MD, of the Kyoto Prefectural University of Medicine, Japan, presented the results of this five-year clinical study examining the protective role of lycopene and other nutrients in people at high risk of liver
cancer. There was a 50 percent decrease in hepatocellular carcinoma (HCC or liver cancer) in participants who daily consumed 10 milligrams of tomato lycopene plus other tomato phytonutrients, 10 milligrams of carotenes (30 percent alpha, 60 percent beta-carotene), and 50 milligrams of alpha-tocopherols and another
form of vitamin E, tocotrienols" - See
iHerb lycopene products. My favorite is
Lyco-Sorb, which has the brand name Lyc-O-Mato.
- Cancer Researchers Keen on Tomatoes - WebMD, 11/11/02 -
"For example, a five-year Japanese study shows daily use of a supplement that contained a combination of natural tomato
extract, beta-carotene, and vitamin E might be an effective way to reduce the risk of liver cancer in those at risk. Researchers found that patients who received the supplement had a 50% suppression of liver cancer" - See
lycopene products. My favorite is
Lyco-Sorb, which has the brand name Lyc-O-Mato.
- Vitamin K Therapy Slows Spread of Liver Cancer - Doctor's Guide, 5/29/02 -
"Results show that 59 percent of patients treated with
vitamin K-II were alive at two years compared to 29 percent of those who were not given vitamin K-II (p=0.14). Invasion of the cancer into the portal vein occurred in 2 percent of the vitamin K-II treated group at one year and in 13 percent at two years,
compared to 21 and 55 percent of controls, respectively" - See
Vitamin K2 products at iHerb. Vitamin K3 (menadione sodium bisulfite) is put in animal foods and animal vitamins. Places that sell it in bulk are
http://www.dyets.com/ordering.htm ($156/kilogram). A company at 360-387-0129 called me and said they sell it also.
- Schisandra Berries More Than a Liver Aid - Nutrition Science News, 1/01
- Chemicals in apples slow cancer growth in lab tests, scientists report - CNN, 8/30/00
- Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 -
"The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity
after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases"
Medications and the Risk of Hepatocellular Cancer: A Systematic Review and
Meta-Analysis - Am J Gastroenterol. 2013 Feb 5 -
"anti-diabetic medications (ADMs) ... performed a systematic review and
meta-analyses of studies evaluating the effect of metformin,
thiazolidinediones (TZDs), sulfonylureas, and/or insulin on the risk of HCC
... Meta-analysis of observational studies showed a 50% reduction in HCC
incidence with metformin use (n=8 studies; OR 0.50, 95% CI 0.34-0.73), 62%
and 161% increase in HCC incidence with sulfonylurea (n=8 studies; OR 1.62,
95% CI 1.16-2.24) or insulin use (n=7; OR 2.61, 95% CI 1.46-4.65),
respectively. TZDs did not modify the risk of HCC (n=4; OR 0.54, 95% CI
0.28-1.02). There was considerable heterogeneity across studies, which was
partly explained by study setting, location, and whether the studies
adjusted for the concomitant use of other ADMs"
Combination of two drugs reverses liver tumors, study suggests - Science
Novel therapeutic approach for liver cancer identified - Science Daily,
Radioembolization improves chance of survival for liver cancer patients,
study suggests - Science Daily, 8/22/11
Liver Cancer Linked to Metabolic Syndrome - Medscape, 7/28/11 -
"hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (ICC) ... metabolic syndrome was significantly more
common in individuals who developed HCC (37.1%) and ICC (29.7%) than in a
comparison group (17.1%; P < .0001). Even after multiple logistic regression
analyses, metabolic syndrome remained significantly associated with an
increased risk for both HCC (odds ratio, 2.13; P < .0001) and ICC (odds
ratio, 1.56; P < .0001)"
Metabolic syndrome increases risk of both major types of primary liver
cancer - Science Daily, 7/21/11 - "metabolic
syndrome was present in 37% of persons who subsequently developed HCC and
30% of persons who developed ICC, compared to 17% of persons who didn't
develop either cancer. Analyses showed metabolic syndrome was significantly
associated with increased risk of HCC (odds ratio=2.13) and ICC (odds
ratio=1.56). Individual components of metabolic syndrome -- impaired fasting
glucose level, dyslipoproteinemia, obesity and hypertension -- were more
common among persons who developed either HCC or ICC patients than among
persons who did not"
Celecoxib May Fight
Liver Cancer - Medscape, 5/24/11
Metabolic syndrome may increase risk for liver cancer - Science Daily,
4/3/11 - "metabolic syndrome, a constellation of
conditions that increases the risk of heart disease and diabetes, may also
increase the risk of the two most common types of liver cancer ... The
prognosis for liver cancer is only marginally better than the prognosis for
pancreatic cancer, with a five-year survival of approximately 10 percent ...
the persons with liver cancer were significantly more likely than
cancer-free persons to have a prior history of metabolic syndrome: 37.1
percent of patients with hepatocellular carcinoma had pre-existing metabolic
syndrome, as did 29.7 percent of patients with intraheptic carcinoma; only
17.1 percent of the cancer-free adults had metabolic syndrome"
Liver cancer in cirrhotic patients effectively treated with radiofrequency
ablation, study suggests - Science Daily, 12/16/10
Adiponectin shows potential in blocking obesity-related carcinogenesis -
Science Daily, 10/19/10 - "our results suggest an
attractive molecular strategy employing adiponectin analogues for potential
therapy of metastatic HCC ... With the prevalence of obesity in the U.S.,
our study could significantly improve overall survival for a vast number of
obese liver cancer patients by using adiponectin to inhibit growth,
invasion, and migration of HCC cells"
Recent Advances in the
Treatment of Hepatocellular Carcinoma: Abstract and Introduction -
Science Daily, 4/26/10
Radiology procedure may help increase long-term survival in patients with
severe liver cancer - Science Daily, 11/20/09
Cases Of Liver Cancer Reduced In Younger Population Vaccinated For Hepatitis
B - Science Daily, 9/16/09 - "A 20-year
follow-up study revealed a dramatic drop in liver cancer cases among 6- to
19-year-olds who were vaccinated for the hepatitis B virus at birth"
Microwave Technique Successful In Treatment Of Liver Tumors, Surgeon Shows
- Science Daily, 5/14/09
Hypothyroidism In Women Associated With Liver Cancer - Science Daily,
5/8/09 - "Women with a history of hypothyroidism
face a significantly higher risk of developing liver cancer ... Whether and
why hypothyroidism causes HCC is not clear ... However, the association
between hypothyroidism and NASH can be explained by the underlying
hyperlipidemia, decreased fatty acid oxidation insulin resistance and lipid
peroxidation in patients with hypothyroidism"
Targeting The Protein AEG1 Impairs Human Liver Cancer Growth In Mice -
Science Daily, 2/16/09
Advanced Liver Cancer Patients Live Longer By Taking Anti-cancer Drug
Sorafenib - Science Daily, 7/23/08
Virus-Based Drug Attacks Liver Cancer - WebMD, 6/5/08
Sutent, Tykerb May Curb Liver Cancer - Science Daily, 4/16/08
Combining Liver Cancer Treatments Doubles Survival Rates, Study Suggests
- Science Daily, 4/15/08
Sunitinib May Slow Growth And Spread Of Liver Cancer - Science Daily,
High-energy Ultrasound Sharpens View Of Liver Tumors - Science Daily,
Radio Waves Fire Up Nanotubes Embedded In Tumors, Destroying Liver Cancer
- Science Daily, 11/1/07
ScienceDaily: Improving Liver Cancer Diagnosis - Science Daily, 10/5/07
Sorafenib Boosts Survival in Patients With Advanced Liver Cancer -
Doctor's Guide, 9/28/07
Test Improves Detection Of Liver Cancer - Science Daily, 8/8/07
Liver Cancer Is More Prevalent In Males Than In Females - Science Daily,
7/5/07 - "By eliminating IL-6, we reduced the
incidence of liver cancer in the males by close to 90%"
Sorafenib for Advanced Liver Cancer - Medscape, 6/11/07
Liver cancer: Kidney drug buys time - USA Today, 6/4/07
Sorafenib is Well-Tolerated in Liver Cancer - Doctor's Guide, 11/17/06
Elevated ALT Levels Predict Risk of Death From Liver Cancer - Medscape,
11/2/06 - "Upper limits of normal
range from 30 IU/L to 60 IU/L, depending on the laboratory. "We want to
reset it southward of 30 IU/L," ... ALT levels are a reflection of the
general vascular condition ... If the level is above 30, then that person
probably has a problem fatty liver or some vascular disease, including
occlusive coronary artery disease"
Anti-Inflammatory Drug Prevents Liver Cancer in at-Risk Liver Patients -
Doctor's Guide, 9/12/06
FDA Grants Orphan Drug Designation to Nexavar (Sorafenib) for the Treatment
of Hepatocellular Carcinoma - Doctor's Guide, 4/26/06
Chemoembolization Effective in Destroying Liver Tumors - Doctor's Guide,
Metastatic Cancer in the Liver Controlled With Treatment of Yttrium-90
Microspheres - Doctor's Guide, 4/4/06
Yttrium-90 Controls Liver Cancer Over Long Term - Doctor's Guide, 4/4/06
Radiofrequency Ablation Equivalent to Open Surgery in Survival of Isolated
Liver Cancer - Doctor's Guide, 4/3/06
Intraoperative Ultrasound Better Than CT or PET In Detecting Liver
Metastases - Doctor's Guide, 3/27/06
Hepatocellular Carcinoma Treatment Options Remain Limited, but New Avenues
Are Being Explored: Presented at HEP DART - Doctor's Guide, 12/20/05
Magnetic Resonance-Guided Laser Ablation Effective for Treating Liver
Metastases - Doctor's Guide, 11/30/05
Survival Unaffected by Interferon Alpha-2b after Surgical Resection for
Liver Cancer - Doctor's Guide, 11/15/05
Precision Radiation Therapy Yields Rare Success For Liver Tumors -
Science Daily, 10/24/05
Treating Liver Metastases in Colorectal Cancer: An Expert Interview With
Michael Choti, MD - Medscape, 6/16/05
Unique Dual Treatment For Liver Cancer Packs Curative Punch - Science
Expandable Electrodes Safe And Effective For Radiofrequency Ablation Of
Liver Tumors - Science Daily, 5/22/05
Expandable Electrodes Safe and Effective for Radiofrequency Ablation of
Liver Tumors - Doctor's Guide, 5/17/05
Transcatheter Arterial Chemoembolization Has Minimal Toxicity in Inoperable
Liver Cancer - Doctor's Guide, 4/6/05
Radiologists Offer Non-surgical Treatment For Early-stage Liver Cancer -
Science Daily, 3/5/05
Chemotherapy Can Rescue Inoperable Colorectal Liver Metastases -
Doctor's Guide, 3/4/05
- Radiofrequency Ablation Appears to Be Effective Non-Surgical Treatment for Early-Stage Liver Cancer - Doctor's Guide, 2/16/05
- Hepatic Artery Infusion Chemoembolisation Beneficial in Patients With Liver Cancer - Doctor's Guide, 2/3/05
- MRI Shows Liver Tumors Freezing In Real Time - Science Daily, 12/8/04
- Liver Metastases Destroyed by Cold Ablation - Doctor's Guide, 12/1/04
- Radiofrequency Ablation Appears to be Safe for Treating Liver Tumors Pushing on Gastrointestinal Tract - Doctor's Guide, 11/3/04
- Energy Blocker' Kills Big Tumors In Rats - Science Daily, 10/18/04
- Novel Yttrium-90 Microspheres (TheraSphere) Deliver High Radiation Levels Yet Protects Normal Tissue in Non-Resectable Liver Carcinoma - Doctor's Guide, 3/31/04
- Combo Treatment for Liver Cancer Is Effective - WebMD, 3/30/04
- Chemoembolisation + Radio Frequency Ablation May Offers Durable Local Control for Liver Tumours - Doctor's Guide, 3/30/04
- Chemoembolization Plus Radiofrequency Ablation Effective for Local Control of Liver Cancer - Medscape, 3/29/04
- Interferon-Alpha May Be Safe, Effective In Preventing Hepatocellular Carcinoma Recurrence After Ablation Therapy - Doctor's Guide, 1/30/04
- Laser-Induced Thermotherapy May Be Better Than Surgery for Liver Metastases - Doctor's Guide, 12/5/03
- Chemotherapy Delivered Into Hepatic Artery Highly Effective for Liver Metastases - Doctor's Guide, 12/4/03
- Study Establishes Effectiveness of Radiofrequency Ablation for Treatment of Primary Liver Cancer - Doctor's Guide, 11/6/03
- Topical Testosterone Gel Appears to Benefit Patients Awaiting Liver Transplant - Doctor's Guide, 10/29/03
- Transarterial Chemoembolization Prepares Liver Metastases for Laser Tx - Medscape, 10/28/03
- Outpatient Combination Treatment Shrinks Liver Tumors To Acceptable Size For Laser Procedure - Doctor's Guide, 10/28/03
- Fatty Liver Increases Cancer Risk - Doctor's Guide, 3/27/03
- A New Approach For Un-Resectable Colorectal Liver Metastases - Doctor's Guide, 3/21/03
- Aggressive Therapy of Liver Metastases Appears Cost-Effective - Doctor's Guide, 12/5/02
- Pilot Study Suggests Photodynamic Therapy Effective for Liver Metastases - Doctor's Guide, 12/5/02
- New Ultrasound Technique Improves Differentiation of Benign and Malignant Liver Lesions - Doctor's Guide, 12/2/02
- Intra-Arterial Delivery System Localises Treatment of Hepatocellular Carcinoma - Doctor's Guide, 11/22/02
- Chemoembolization May Be Treatment of Choice in Liver Cancer Subgroup - Medscape, 11/6/02
- Effective Therapy Still Lacking For Resectable Hepatocellular Carcinoma - Doctor's Guide, 10/14/02
- Laparoscopic Resection Of Small Left Lateral or Anterior Segments of Right Liver Tumours Safe - Doctor's Guide, 7/16/02
- Chemoembolization Improves Survival in Liver Cancer - Medscape, 5/22/02
- Fotemustine Prolongs Survival in Patients with Liver Metastases from Ocular Melanoma - Doctor's Guide, 5/20/02
- Chemoembolisation Adds Survival Time In Untreatable Liver Cancer - Doctor's Guide, 5/20/02
- Environmental Factors Could Play Hypermethylation Role In Cancer - Doctor's Guide, 5/16/02
- Brachytherapy Demonstrates Promise in Tough-to-Treat Liver Cancer - Doctor's Guide, 2/4/02
- New Electrolysis Treatment For Liver Cancer Continues to Impress - Doctor's Guide, 11/8/01
- Hepatitis C Drug May Help Stop Liver Cancer Recurrence, Interferon Alpha, Given After Surgery, Shows Promise - WebMD, 5/30/01 -
"The drug, called interferon alpha, appears to help prevent the return
of liver cancer in people with hepatitis C who have had a tumor removed surgically"
- New Treatment, TheraSphere, May Be Welcome Alternative For Inoperable Liver Cancer - Doctor's Guide, 5/15/01 -
"TheraSphere is a unique new targeted therapy that spares healthy tissue while providing
radiation directly to liver tumors"
- Scientists Coax Liver Cells Into Growing On Silicon Chip - Intelihealth, 5/10/01
- Hepatic Artery Chemotherapy Improves Survival In Patients With Liver Metastases - Doctor's Guide, 5/19/00
- Chemotherapy Delivered Directly To Liver Tumours Can Extend Lives - Doctor's Guide, 3/22/99
- New Radiation Procedure Targets Liver Cancer - Doctor's Guide, 6/1/98