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Home > Anti-aging Research > Selenium

Selenium (Cimicifugae racemosae rhizoma)

Specific Recommendations (for organic selenium):

• Selenium products at iHerb
• Selenium products at Vitacost
• Drugstore.com/GNC selenium products

General Information:

• Selenium - Vitacost Health Library
• Selenium Summary - M. D. Anderson Cancer Center
• Is Selenium Deficiency Behind Ebola and AIDS - thenutritionreporter.com

News & Research:

• Selenium Danger? - Dr. Weil, 9/11/08
• Diet And Medications May Assist Prevention Of Prostate Cancer - Science Daily, 9/24/07 - "dutasteride, has reduced by 50 percent the number of cancerous biopsies among men with benign prostatic hypertrophy ... In one study of selenium, the incidence of prostate cancer was reduced by 49 percent over ten years ... Data already suggests novel uses of statins, commonly prescribed cholesterol-lowering agents, and insulin modulating drugs, such as metformin or the glitazones" - See dutasteride at OffshoreRX.com.
• Low selenium levels may be weakening muscles - Nutra USA, 8/27/07 - "people with the lowest plasma concentrations were 69, 94 and 94 per cent more likely to have poor hip, knee, and grip strength, compared to those with the highest selenium levels" - [Abstract]
• Selenium Supplements: Diabetes Risk - WebMD, 7/9/07 - "During the study, 58 participants in the selenium group reported being diagnosed with type 2 diabetes, compared with 39 people taking the placebo"
• Selenium - Important Health Benefits from an Overlooked Trace Mineral - Life Extension Magazine, 11/06 - "As scientists continue to discover the many ways in which oxidative stress is related to inflammation and its destructive consequences—from atherosclerosis to prostate, lung, colon, and other cancers—the disease-preventive powers of selenium are likely to receive even greater scrutiny"
• More support that selenomethionine most bioavailable form - Nutra USA, 6/15/06
• Selenium-protein Deficiency Raises Prostate Cancer Risk - Science Daily, 5/23/06 - "Selenium, an essential dietary mineral that can act as an antioxidant when incorporated into proteins, has been shown in many studies to reduce the incidence of cancers -- notably lung, colorectal and prostate"
• Low Selenium Levels Might Raise Odds of Knee Osteoarthritis - Doctor's Guide, 11/21/05 - "low toenail selenium levels correlated positively to increased risk of radiographic knee osteoarthritis"
• Low selenium linked to higher risk of osteoarthritis - Nutra USA, 11/14/05 - "Those with the highest selenium levels faced a 40 per cent lower risk of knee osteoarthritis than those in the lowest-selenium group"
• Selenomethionine More Bioavailable Than Selenite - Natural Products Industry Insider, 4/21/05
• Selenomethionine has superior bioavailability, suggests study - Nutra USA, 4/19/05 - "selenomethionine is twice as bioavailabile as selenium in the form of selenite"
• Getting Serious about Selenium - Life Extension Magazine, 12/04
• Selenium May Lower Colon Cancer Risk - WebMD, 11/16/04 - "participants with the highest blood levels of selenium were 34% less likely to develop a new adenoma compared with those with the lowest selenium blood levels"
• Selenium and Prostate Cancer - Physician's Weekly, 6/14/04 - "higher levels of selenium may slow prostate cancer tumor progression"
• When Good Antioxidants Are Bad - WebMD, 6/14/04
• Antioxidant Enzyme Containing Selenium, A Major Dietary Supplement, Could Promote Type 2 Diabetes - Science Daily, 6/11/04
• Selenium Reduces Prostate Cancer Risk - Natural Foods Merchandiser, 1/04
• Selenium Supplements May Reduce Breast Cancer Risk in Some - WebMD, 6/16/03 - "a certain version of the gene was associated with a higher breast cancer risk. That same gene was also less responsive to selenium stimulation ... that means people with this genetic variation may benefit from selenium supplements but they require a higher dose to achieve selenium's protective effect against cancer"
• Selenium May Lower Risk Of Esophageal Cancer In People With Barrett's Esophagus - Intelihealth, 5/21/03 - "Higher serum selenium levels appear to be associated with a reduced risk of progression toward esophageal cancer among people with Barrett's esophagus"
• Selenium May Inhibit Progression Toward Esophageal Cancer In Patients With Barrett's Esophagus - Doctor's Guide, 5/21/03
• Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 - "Companies that manufacture selenium supplements will now be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers"
• Selenium May Fight Prostate Damage - WebMD, 2/4/03 - "About 80% of the prostate cells in dogs fed a normal diet had extensive DNA damage compared with only about 57% in the selenium-treated dogs ... dogs fed the enriched diet also had a twofold increase in the number of prostate cells that had undergone a process that removes damaged cells, called apoptosis, which is associated with a lower risk of cancer"
• Mineral [selenium] Cuts Bladder Cancer in Smokers - WebMD, 11/1/02
• High Selenium Consumption May Protect Ex-Smokers From Bladder Cancer - Intelihealth, 10/31/02
• Few Vitamins Effectively Prevent or Reverse Skin Damage - Medscape, 3/02 - "Recent animal studies have found that when selenium is taken orally or through the skin in the form of L-selenomethionine, it provided protection against both everyday and excessive UV damage"
• Staying Young Forever, Putting new research findings into practice - Life Extension Foundation, 12/99
• Intake Of Apples And Selenuim Affects Incidence Of Asthma - Intelihealth, 12/13/01 - "Eating at least two or more apples per week and a higher intake of the essential metal selenium can protect against asthma in adults, according to British researchers ... They reported on a population-based, case-control study to determine whether asthma is less common and less severe in adults who consume more dietary antioxidants"
• Low Selenium Levels Linked With Increased Prostate Cancer Risk - Intelihealth, 12/6/01
• Selenium May Help Prevent Prostate Cancer - Doctor's Guide, 11/30/01 - "Men with low blood levels of selenium -- a trace element supplied in certain foods and supplements -- are four to five times more likely to contract prostate cancer ... the researchers concluded that the results support the hypothesis that supplemental selenium may reduce the risk of prostate cancer. Because selenium in blood decreases with patient age, supplementation may be beneficial to older men"
• Selenium Supplementation May Benefit Patients With Thyroiditis - Doctor's Guide, 6/22/01
• Selenium: New entry in fight against prostate cancer - CNN, 6/16/99
• Selenium Mimics Insulin - Nutrition Science News, 6/01
• Essential Nutrients for Endurance Athletes - Nutrition Science News, 5/99
• Selenium: Antioxidant & Cancer Quencher - Nutrition Science News, 3/99
• Can Selenium Stop Prostate Cancer? - Nutrition Science News, 3/99
• Study: Mineral selenium cuts risk of prostate cancer - CNN, 8/22/98
• Selenium-Based Antihypertensive May Lead To New Family Of Therapeutic Agents - Doctor's Guide, 11/11/97 - "The biochemistry and pharmacology of selenium are subjects of intense current interest because of evidence that a deficiency of the trace nutrient may play a role in diseases as diverse as cancer, heart disease, arthritis and AIDS. Selenium is an antioxidant involved in many important enzyme processes"
• Selenium Is Found to Reduce Cancer Mortality by 50 Percent - Life Extension Magazine, 6/97
• Selenium may lower several cancer risks - CNN, 12/24/96

Abstracts:

• Serum selenium and serum lipids in US adults - Am J Clin Nutr. 2008 Aug;88(2):416-23 - "Elevated serum selenium was associated with elevated serum concentrations of total cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols, apo B, and apo A-I among US adults, a selenium-replete population"
• Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats - Br J Nutr. 2008 Feb 28;:1-6 - "tocopherol group (T group, positive control), selenite group (SE group, representing the inorganic Se group) and seleno-yeast group (SY group, representing the organic Se group) ... MAO-B activity showed a significant decrease in the T, SE and SY groups in rat brains but no significant change could be noted in the rat livers. In conclusion, the present study indicates that inorganic or organic Se supplementation can decrease the brain MAO-B enzyme activity in adult rats and can be accomplished by the effect of the Se antioxidation capability"
• Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults - Arch Intern Med. 2008 Feb 25;168(4):404-10 - "we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality"
• Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study - Am J Clin Nutr. 2007 Aug;86(2):347-52 - "participants in the lowest versus the highest quartile of plasma selenium were at higher risk of poor hip strength [odds ratio (OR): 1.69; 95% CI: 1.02, 2.83; P = 0.04, P for linear trend = 0.04], knee strength (OR: 1.94; 95% CI: 1.18, 3.19; P = 0.009, P for linear trend = 0.01), and grip strength (OR: 1.94; 95% CI: 1.19, 3.16; P = 0.008, P for linear trend = 0.08)"
• Effects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes: A Randomized Trial - Ann Intern Med. 2007 Jul 9 - "During an average follow-up of 7.7 years (SD, 2.7), type 2 diabetes developed in 58 selenium recipients and 39 placebo recipients (incidence, 12.6 cases per 1000 person-years vs. 8.4 cases per 1000 person-years, respectively; hazard ratio, 1.55"
• Serum selenium and risk of prostate cancer--a nested case-control study - Am J Clin Nutr. 2007 Jan;85(1):209-17 - "higher serum selenium was associated with lower risks in men reporting a high (more than the median: 28.0 IU/d) vitamin E intake"
• Selenium is inversely associated with bladder cancer risk: A report from the Belgian case-control study on bladder cancer - Int J Urol. 2006 Sep;13(9):1180-4 - "This case-control study suggests an inverse association between serum selenium concentration and bladder cancer risk"
• Selenium supplementation and colorectal adenomas: An analysis of the nutritional prevention of cancer trial - Int J Cancer. 2005 Oct 10 - "In addition to being associated with a reduced risk of incident CRC [colorectal cancers], selenium supplementation was associated with a significantly reduced risk of prevalent adenomas, but only among subjects with either a low baseline selenium level or among current smokers"
• Effectiveness of selenium supplements in a low-selenium area of China - Am J Clin Nutr. 2005 Apr;81(4):829-34 - "Selenium as selenomethionine had nearly twice the bioavailability of selenium as selenite"
• Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy - Gynecol Oncol. 2004 May;93(2):320-327 - "we conclude that there are beneficial effects caused by ingesting selenium, as a supportive element in chemotherapy"
• Selenium in the Immune System - J. Nutr. 133:1457S-1459S, May 2003 - "Selenium as an essential component of selenocysteine-containing protein is involved in most aspects of cell biochemistry and function. As such, there is much potential for selenium to influence the immune system"
• Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial - Br J Urol. 1998 May;81(5):730-4
• Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group - JAMA. 1996 Dec 25;276(24):1957-63
• Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps - Cancer Epidemiol Biomarkers Prev. 1993 Jan-Feb;2(1):41-6

Other possible selenium suppliers:

Related Searches:

• Doctor's Guide search of selenium
• Doctor's Guide (2) search of selenium
• Intelihealth search of selenium
• Life Extension Foundation search
• Medline search of selenium
• Medscape search of selenium
• The Natural Pharmacist search of selenium
• Nutrition Science News search
• WebMD search of selenium

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