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Colon Cancer

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Alternative News:

• The Omega-3 Polyunsaturated Fatty Acid Eicosapentaenoic Acid Inhibits Mouse MC-26 Colorectal Cancer Cell Liver Metastasis Via Inhibition Of Prostaglandin E(2) -Dependent Cell Motility - Br J Pharmacol. 2012 Feb 2 - "Treatment with 5% (w/w) EPA-FFA was associated with a reduced MC-26 mouse CRC cell liver tumour burden compared with control animals (median liver weight 1.62g versus 1.03g; P < 0.034). Administration of 5% EPA-FFA was also linked to a significant increase in tumour EPA incorporation and lower intra-tumoral PGE(2) levels (with concomitant increased production of PGE(3) ). Liver tumours from 5% EPA-FFA treated mice demonstrated decreased bromodeoxyuridine-positive CRC cell proliferation and reduced phosphorylated extracellular signal-related kinase 1/2 expression at the invasive edge of tumours. A concentration-dependent reduction in MC-26 CRC cell Transwell® migration following EPA-FFA treatment (50-200µM) in vitro was rescued by exogenous PGE(2) (10µM) and PGE(1) -alcohol (1µM). Conclusions:  EPA-FFA inhibits MC-26 CRC cell liver metastasis. EPA incorporation is associated with a 'PGE(2) to PGE(3) switch' in liver tumours. Inhibition of PGE(2) -EP4 receptor-dependent CRC cell motility likely contributes to the anti-neoplastic activity of EPA" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Regular use of vitamin and mineral supplements could reduce the risk of colon cancer, study suggests - Science Daily, 2/3/12 - "Rats fed a high-fat plus low-fibre diet and exposed to carcinogens developed pre-cancerous lesions; whereas, rats undergoing similar treatment, but provided with daily multivitamin and mineral supplements, showed a significant (84%) reduction in the formation of pre-cancerous lesions and did not develop tumours ... The authors conclude that "multivitamin and mineral supplements synergistically contribute to the cancer chemopreventative potential"
• Fish Oil Supplement Alters Markers of Inflammatory and Nutritional Status in Colorectal Cancer Patients - Nutr Cancer. 2012 Feb 1 - "The supplemented group (SG) consumed 2 g of fish oil containing 600 milligrams of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for 9 wk ... Patients supplemented with fish oil (SG) showed a clinically relevant decrease in the C-reactive protein/albumin relation (P = 0.005). Low doses of fish oil supplement can positively modulate the nutritional status and the C-reative protein/albumin ratio" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Dietary intake of PUFAs and colorectal polyp risk - Am J Clin Nutr. 2012 Jan 25 - "n-6 PUFAs were not associated with adenomatous or hyperplastic polyps in either men or women. Marine-derived n-3 PUFAs were associated with reduced risk of colorectal adenomas in women only, with an adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of α-linolenic acid was associated with an increased risk of hyperplastic polyps in men (P-trend = 0.03), which was not seen in women" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Preoperative Probiotics Decrease Postoperative Infectious Complications of Colorectal Cancer - Am J Med Sci. 2011 Dec 23 - "The preoperative oral bifid triple viable probiotics minimize the postoperative occurrence of infectious complications, with possible mechanisms attributed to the maintenance of the intestinal flora and restriction of bacterial translocation from the intestine. It was representative of the enhancement of systemic/localized immunity and concurrent attenuation of systemic stress response" - See probiotic products at iHerb.
• Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health Initiative - Eur J Clin Nutr. 2011 Dec 14 - "Previous cohort studies examining the association of serum antioxidant levels and risk of colorectal cancer have used a single (baseline) measurement only. In the present study, we assessed the association of serum levels of eight antioxidant nutrients in relation to risk of colorectal cancer, using repeated measurements ... Serum antioxidants measured at baseline generally showed no association with risk of colorectal cancer, although serum β-carotene at baseline showed a non-significant inverse association with colon cancer alone. Furthermore, using the repeated measurements of β-carotene, the average of all measurements was inversely associated with risk of both colorectal and colon cancer: HRs for highest vs lowest tertile 0.54, 95% CI 0.31-0.96, and 0.47, 95% CI 0.25-0.88, respectively. No associations were seen with other antioxidant nutrients in the repeated measure analyses" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex, 60 Softgels at iHerb.
• High-Fiber Diet Linked to Lower Colon Cancer Risk - WebMD, 11/11/11 - "Total fiber intake, as well as fiber from whole grains and from cereals, was most strongly linked with a reduction in colorectal cancer risk ... The evidence was weaker for fiber from fruits, vegetables, and legumes"
• Health risk from eating well-done meat may be underestimated - Science Daily, 11/1/11 - "the incidence of intestinal tumours increased from 31 per cent to 80 per cent in "human-like" mice who consumed substances from meat crust (i.e. the surface formed during heat-treatment) ... Heat-processing of food can lead to the formation of carcinogenic substances. The formation of carcinogenic substances -- so-called food mutagens -- usually occurs at high temperatures when frying or grilling"
• Dietary patterns may be linked to increased colorectal cancer risk in women - Science Daily, 10/24/11 - "High red meat intake, fish intake, sugar-sweetened beverage intake, but low coffee, whole grains and high-fat dairy intake, when taken as a whole, seemed to be associated with higher levels of C-peptide in the blood ... C-peptide is a marker of insulin secretion that can be measured in a person's blood. High levels of insulin may promote cell growth and multiplication. One of the major characteristics of cancer is aberrant cell growth. Higher levels of C-peptide, and therefore insulin, may promote cancer cell growth ... Colon cancer seems to be one of the cancers that are sensitive to insulin ... women who most often consumed high amounts of red meat, fish and sugar-sweetened beverages and low amounts of high-fat dairy, coffee and whole grains had a 35 percent increased risk for colorectal cancer"
• Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue - Br J Nutr. 2011 Sep 30:1-12 - "Modulation of the cellular response by the administration of probiotic bacteria may be an effective strategy for preventing or inhibiting tumour growth. We orally pre-inoculated mice with probiotics Lactobacillus acidophilus NCFM (La) for 14 d. Subcutaneous dorsal-flank tumours and segmental orthotopic colon cancers were implanted into mice using CT-26 murine colon adenocarcinoma cells. On day 28 after tumour initiation, the lamina propria of the colon, mesenteric lymph nodes (MLN) and spleen were harvested and purified for flow cytometry and mRNA analyses. We demonstrated that La pre-inoculation reduced tumour volume growth by 50.3 %, compared with untreated mice at 28 d after tumour implants (2465.5 (sem 1290.4) v. 4950.9 (sem 1689.3) mm3, P < 0.001)" - See probiotic products at iHerb.
• Low-Dose Dietary Resveratrol Has Differential Effects on Colorectal Tumorigenesis in Adiponectin Knockout and Wild-Type Mice - Nutr Cancer. 2011 Sep 29 - "Obesity is associated with a decrease in the antiinflammatory hormone, adiponectin, and increases in the circulating concentrations of multiple proinflammatory cytokines. These changes contribute to colon tumorigenesis. Resveratrol increases adiponectin production in adipocytes and attenuates the development of colon cancer. Thus, we hypothesized that adiponectin is an integral component of the mechanism by which resveratrol antagonizes colorectal tumorigenesis. To investigate this, we induced tumorigenesis in adiponectin knockout (KO) and wild-type (Wt) C57BL/6 mice through combined azoxymethane and dextran sodium sulfate treatment during which mice were fed a high-fat, lard-based diet, or the same diet containing 20 mg/kg resveratrol. After 14 wk on diet, Wt mice gained more weight and, on a percentage basis, had higher fat mass and lower lean mass than KO mice. Resveratrol tended to attenuate this response in male Wt mice. Resveratrol also tended to reduce aberrant crypt foci development and decrease circulating interleukin 6 and insulin concentrations in male but not female Wt mice. Taken together, resveratrol improved overall health of obese Wt but not KO mice as hypothesized with a differential sex response" - See resveratrol products at iHerb.
• Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side by side comparison - J Agric Food Chem. 2011 Sep 20 - "Cell viability tests indicated that IC50s of pterostilbene were 2~5-fold lower than those of resveratrol in all three cancer cells. Pterostilbene was also more potent in inhibiting colony formation of all three cancer cells. Annexin V/Propidium Iodide (PI) co-staining assay and western blotting analysis showed pterostilbene had stronger apoptosis-inducing effects, which was evidenced by the higher percentage of annexin V positive cells and higher levels of cleaved caspae-3 and Poly (ADP-ribose) polymerase (PARP) proteins in cancer cells treated with pterostilbene than resveratrol. High performance liquid chromatography (HPLC) analysis demonstrated that intracellular levels of pterostilbene were 2~4-fold higher than those of resveratrol after treatments with individual compounds at the same concentration. Overall, our results demonstrated that pterostilbene had more potent inhibitory effects on colon cancer cells than resveratrol, which may be associated with the superior bioavailability of pterostilbene to resveratrol" - See pterostilbene products at iHerb.
• The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus - Int J Cancer. 2011 Sep 12 - "Metformin use has been associated with decreased cancer risk and mortality ... We identified 595 patients who were diagnosed both CRC and diabetes mellitus. Patients were compared by two groups; 258 diabetic patients taking metformin and 337 diabetic patients not taking metformin ... After a median follow-up of 41 months, there were 71 total deaths (27.5%) and 55 CRC-specific deaths (21.3%) among 258 patients who used metformin, compared with 136 total deaths (40.4%) and 104 CRC-specific deaths (30.9%) among 337 patients who did not use metformin. Metformin use was associated with decreased overall mortality (P=0.018) and CRC-specific mortality (P=0.042) by univariate analysis. After adjustment for clinically relevant factors, metformin use showed lower risk of overall mortality (HR, 1.45; 95% CI, 1.084-1.934; P=0.016) and CRC-specific mortality (HR, 1.44; 95% CI, 1.026-2.061; P=0.035) in CRC patients with diabetes. Metformin use in CRC patients with diabetes is associated with lower risk of CRC-specific and overall mortality" - See metformin at IAS.
• Association Between Vitamin D and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies - J Clin Oncol. 2011 Aug 29 - "Relevant studies were identified by a search of MEDLINE and EMBASE databases before October 2010 with no restrictions ... The pooled RRs of colorectal cancer for the highest versus lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95% CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no heterogeneity among studies of vitamin D intake (P = .19) or among studies of blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level conferred an RR of 0.74 (95% CI, 0.63 to 0.89) ... Vitamin D intake and blood 25(OH)D levels were inversely associated with the risk of colorectal cancer in this meta-analysis" - See vitamin D products at iHerb.
• Confirmation that vitamin D acts as a protective agent against the advance of colon cancer - Science Daily, 8/16/11 - "A study conducted by VHIO researchers confirms that a lack of vitamin D increases the aggressiveness of colon cancer ... In light of these findings, chronic vitamin D deficiency represents a risk factor in the development of more aggressive colon tumours. Patients in the initial stages of colon cancer, the time when the VDR still has a substantial presence in the cells, could benefit from being treated with vitamin D3. However, this would not be useful in the advanced stages of the disease when the presence of the VDR is very much reduced" - See vitamin D products at iHerb.
• Cooked Green Vegetables, Dried Fruit, Legumes, and Brown Rice Associated With Fewer Colon Polyps - Science Daily, 8/2/11 - "Eating legumes at least three times a week and brown rice at least once a week was linked to a reduced risk of colon polyps by 33 percent and 40 percent respectively ... Results also show that consuming cooked green vegetables once a day or more, as compared to less than five times a week, was associated with a 24 percent reduction in the risk of rectal/colon polyps. Consuming dried fruit three times a week or more, versus less than once a week, was associated with a 26 percent reduced risk"
• S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions - Cancer Lett. 2011 Jun 30 - "S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy" - See garlic products at iHerb.
• Colon cleansing has no benefit but many side effects including vomiting and death, doctors say - Science Daily, 8/1/11 - "while these reports show little evidence of benefit, there is an abundance of studies noting side effects following the use of cleansing products including cramping, bloating, nausea, vomiting, electrolyte imbalance and renal failure ... Some herbal preparations have also been associated with aplastic anemia and liver toxicity ... organizations such as the National Board for Colon Hydrotherapy and others who promote colon cleansing require hygienists to have little more than a high school diploma"
• High folate intake may reduce risk of colorectal cancer - Science Daily, 7/5/11 - "We found that all forms and sources of folate were associated with lower risk of colorectal cancer ... A research team investigated the association between folate intake and colorectal cancer among 99,523 participants in the Cancer Prevention Study II Nutrition Cohort; a total of 1,023 participants were diagnosed with colorectal cancer between 1999 and 2007 ... The study also addressed concerns that the intake of high levels of folate frequently consumed in the U.S. -- as a result of the recent increase in the use of folate-containing supplements and mandatory folate fortification of food -- may actually increase risk of cancer. No increased risk of colorectal cancer was found for the highest intake levels, suggesting that the high levels of this vitamin consumed by significant numbers of Americans should not lead to increased incidence rates of this cancer in the population" - See folic acid products at iHerb.
• Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive, and angiogenic biomarkers - Int J Cancer. 2011 Jun 23 - "We found that the oral administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of CRC tumors in mice, resulting in decrease in tumor volumes than those seen in vehicle-treated mice without significant decreases in body weight. In addition, we observed that AKBA was highly effective in suppressing ascites and distant metastasis to the liver, lungs, and spleen in orthotopically-implanted tumors in nude mice. When examined for the mechanism, we found that markers of tumor proliferation index Ki-67 and the microvessel density CD31; were significantly downregulated by AKBA treatment. We also found that AKBA significantly suppressed NF-κB activation in the tumor tissue and expression of pro-inflammatory (COX2), tumor survival (bcl-2, bcl-xL, IAP-1, survivin), proliferative (cyclin D1), invasive (ICAM-1, MMP-9) and angiogenic (CXCR4 and VEGF) biomarkers. When examined for serum and tissue levels of AKBA, a dose-dependent increase in the levels of the drug was detected, indicating its bioavailability. Thus, our findings suggest that this boswellic acid analogue can inhibit the growth and metastasis of human CRC in vivo through downregulation of cancer-associated biomarkers" - See boswellia products at iHerb.
• Strong Evidence Links Meat to Higher Risk for Colon Cancer - Medscape, 5/30/11 - "For red and processed meat, the findings from 10 new studies were added to the 14 studies that were evaluated in the 2007 report. From these 24 studies, the panel confirmed that there is convincing evidence that both red and processed meat can increase the risk for colorectal cancer ... The WCRF/AICR recommend that the consumption of red meat be limited to 500 g/week, which is roughly the equivalent of 5 or 6 medium portions of beef, lamb, or pork. They also recommend that processed meat be avoided ... According to their data, if 3.5 ounces of red meat are consumed every day (24.5 ounces per week), the risk for colorectal cancer will be 17% higher than if no red meat is consumed. If the amount of red meat consumed is doubled (7.0 ounces every day; 49 ounces per week), the risk is 34% higher. However, the evidence found that there was very little increase in risk for individuals who ate less than 18 ounces of red meat per week ... The cancer risk associated with processed meat, which includes ham, bacon, pastrami, hot dogs, and sausages, was much higher. Consuming 3.5 ounces every day (24.5 ounces per week) was associated with a risk that is 36% higher than the risk of consuming no processed meat. As with red meat, the higher the rate of consumption, the higher the risk for colorectal cancer"
• Yogurt consumption and risk of colorectal cancer in the italian EPIC cohort - Int J Cancer. 2011 May 23 - "Yogurt intake was inversely associated with CRC risk. For the energy-adjusted model, HR for CRC in the highest vs. lowest tertile of yogurt intake was 0.62 (95%CI, 0.46-0.83). In the full model adjusted for energy, simple sugar, calcium, fiber, animal fat, alcohol, and red meat intake, as well as body mass index, smoking, education and physical activity, HR was 0.65 (95%CI, 0.48-0.89) in the highest vs. lowest tertile. The protective effect of yogurt was evident in the entire cohort, but was stronger in men, although there was no interaction of sex with the yogurt-CRC association (P-interaction 0.20, fully-adjusted model). In this prospective study, high yogurt intake was significantly associated with decreased CRC risk, suggesting that yogurt should be part of a diet to prevent the disease" - Note:  I started a web page on just yoghurt instead of putting the yoghurt articles on my Pro-biotics page.  I also put my yoghurt recipe there.  I nearly live on that stuff because I have trouble swallowing after my neck cancer surgery six and a half years ago.
• Folic acid supplementation not associated with colon cancer: Meta-analysis - Nutra USA, 5/9/11 - "New research analysing data from the three largest trials of folic acid and the risk of colon cancer has suggested that supplementation has no effect on the risk of developing the disease ... Interestingly, we observed a potential beneficial effect of folic acid supplements on overall mortality" - [Abstract]
• Foods and Food Groups Associated With the Incidence of Colorectal Polyps: The Adventist Health Study - Nutr Cancer. 2011 May 4:1 - "Colorectal cancer (CRC) is a leading cause of cancer death in the United States. The majority of CRC arise in adenomatous polyps and 25-35% of colon adenoma risk could be avoidable by modifying diet and lifestyle habits ... Multivariate analysis adjusted by age, sex, body mass index, and education showed a protective association with higher frequency of consumption of cooked green vegetables (OR 1 time/d vs. <5/wk = 0.76, 95% CI = 0.59-0.97) and dried fruit (OR 3+ times/wk vs. <1 time/wk = 0.76, 95%CI = 0.58-0.99). Consumption of legumes at least 3 times/wk reduced the risk by 33% after adjusting for meat intake. Consumption of brown rice at least 1 time/wk reduced the risk by 40%. These associations showed a dose-response effect. High frequency of consumption of cooked green vegetables, dried fruit, legumes, and brown rice was associated with a decreased risk of colorectal polyps"
• Canola oil protects against colon cancer, study suggests - Science Daily, 4/19/11 - "canola oil inhibited the average number of tumors per rat by 58 percent compared to one of the other two control diets in the experiment, and inhibited the size of the tumors that occurred by 90 percent ... canola oil inhibited the average number of tumors per rat by 58 percent compared to one of the other two control diets in the experiment, and inhibited the size of the tumors that occurred by 90 percent ... studies have indicated that if consumers use canola as household cooking oil, it could push their ratio of Omega-6 to Omega-3 fatty acids to about 3 to 1. That's very desirable. Humans need Omega-6 fatty acids, too, but they typically consume way too much of them in countries such as the United States ... It should be less than 4 to 1. But in a typical American diet, when we use other oil and butter, our ratio is 10 to 1 or higher. We consume a lot more Omega-6 than Omega-3 fatty acids"
• Vitamin D Status in Patients With Stage IV Colorectal Cancer: Findings From Intergroup Trial N9741 - J Clin Oncol. 2011 Mar 21 - "Vitamin D deficiency is highly prevalent among patients with stage IV colorectal cancer receiving first-line chemotherapy, particularly in black and female patients"
• Pterostilbene ‘more potent than resveratrol’ for colon health: Study - Nutra USA, 3/21/11 - "the chemopreventive effect of pterostilbene was more potent than resveratrol and was associated with a decreased inflammation as well as modulation of the antioxidant signaling pathways in the colons of mice" - [Abstract] - See pterostilbene products at iHerb.
• Pterostilbene ‘more potent than resveratrol’ for colon health: Study - J Agric Food Chem. 2011 Mar 23;59(6):2725-33 - "Inflammatory bowel diseases have been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS) generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously, resveratrol (RS) and pterostilbene (PS) had been reported to prevent chemical-induced colon carcinogenesis by anti-inflammatory and pro-apoptotic properties ... Administrations of PS can be more effective than RS in reducing AOM-induced formation of aberrant crypt foci (ACF), lymphoid nodules (LNs), and tumors. We also find that PS is functioning more effectively than RS to reduce nuclear factor-κB (NF-κB) activation by inhibiting the phosphorylation of protein kinase C-β2 (PKC-β2) and decreasing downstream target gene expression, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and aldose reductase (AR) in mouse colon stimulated by AOM. Moreover, administration of RS and PS for 6 weeks significantly enhanced expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and glutathione reductase (GR), via activation of NF-E2-related factor 2 (Nrf2) signaling. When the above findings are taken together, they suggest that both stilbenes block cellular inflammation and oxidative stress through induction of HO-1 and GR, thereby preventing AOM-induced colon carcinogenesis. In comparison, PS was a more potent chemopreventive agent than RS for the prevention of colon cancer. This is also the first study to demonstrate that PS is a Nrf2 inducer and AR inhibitor in the AOM-treated colon carcinogenesis model" - See pterostilbene products at iHerb.
• Quercetin's Effects on Intestinal Polyp Multiplicity and Macrophage Number in the Apc(Min/+) Mouse - Nutr Cancer. 2011 Mar 1:1 - "Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer; however, experimental studies in rodents are limited. Macrophages play a role in tumorigenesis, but the effects of quercetin on macrophage infiltration in colon cancer is unknown. We examined the effects of quercetin on intestinal polyp multiplicity and macrophage number in Apc(Min/+) mice ... These data suggest that quercetin can reduce polyp number and size distribution in the Apc(Min/+) mouse and that these effects may be related to a reduction in macrophage infiltration" - See quercetin products at iHerb.
• Exercise Reduces Risk for Colon Polyps, Resulting in Less Colon Cancer - Medscape, 3/9/11 - "reanalyzed data collected in 20 clinical trials that reported on physical activity levels (obtained mainly from questionnaires) in individuals who had undergone sigmoidoscopy or colonoscopy (both symptomatic and screening). Most studies did not specify the reason for undergoing the procedure ... Together, these trials involved more than 250,000 individuals ... Overall, there was a significant inverse association between physical activity and colon polyps (fixed-effect relative risk [RR], 0.87; 95% confidence interval [CI], 0.83 to 0.91; random-effects RR, 0.84; 95% CI, 0.77 to 0.92) ... "Our meta-analysis found the effect was stronger, though not significantly so, for large or advanced adenomas than for the overall effect," they add ... The risk reduction (RR, 0.83) was "largely unchanged" when the analysis was restricted to the 18 studies in which the results for adenomatous polyps were separated from all polyps (i.e., hyperplastic, malignant polyps), they report"
• Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms and colorectal cancer risk - Cancer Epidemiol Biomarkers Prev. 2011 Mar 4 - "We observed inverse associations of colorectal cancer risk with dietary vitamin D (summary RR per 100 IU/day=0.95 95%CI: (0.93-0.98); 10 studies; range of intake (midpoints) = 39-719 IU/day) and serum/plasma 25-hydroxyvitamin D (RR per 100 IU/l=0.96 (0.94-0.97); 6 studies; range=200-1800 IU/l), but not with total vitamin D (5 studies). Supplemental (2 studies; range=0-600 IU/day) and total (4 studies; range=79-732 IU/day) vitamin D intake and 25-hydroxyvitamin D status (6 studies; range=200-1800 IU/l) were inversely associated with colon cancer risk. We did not observe statistically significant associations between FokI, PolyA, TaqI, Cdx2 and ApaI VDR polymorphisms and colorectal cancer risk. The BsmI polymorphism was associated with a lower colorectal cancer risk (RR=0.57 (0.36-0.89) for BB vs. bb, 8 studies)" - See vitamin D products at iHerb.
• Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane (AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2 (Nrf2)-Mediated Antioxidant Signaling Pathway - J Agric Food Chem. 2011 Feb 28 - "Inflammatory bowel diseases have been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS) generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously, resveratrol (RS) and pterostilbene (PS) had been reported to prevent chemical-induced colon carcinogenesis by anti-inflammatory and pro-apoptotic properties ... Administrations of PS can be more effective than RS in reducing AOM-induced formation of aberrant crypt foci (ACF), lymphoid nodules (LNs), and tumors. We also find that PS is functioning more effectively than RS to reduce nuclear factor-κB (NF-κB) activation by inhibiting the phosphorylation of protein kinase C-β2 (PKC-β2) and decreasing downstream target gene expression, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and aldose reductase (AR) in mouse colon stimulated by AOM. Moreover, administration of RS and PS for 6 weeks significantly enhanced expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and glutathione reductase (GR), via activation of NF-E2-related factor 2 (Nrf2) signaling. When the above findings are taken together, they suggest that both stilbenes block cellular inflammation and oxidative stress through induction of HO-1 and GR, thereby preventing AOM-induced colon carcinogenesis. In comparison, PS was a more potent chemopreventive agent than RS for the prevention of colon cancer. This is also the first study to demonstrate that PS is a Nrf2 inducer and AR inhibitor in the AOM-treated colon carcinogenesis model"
• Vitamin D linked to colon cancer protection: Meta-analysis - Nutra USA, 2/7/11 - "for every 10 nanograms per milliliter increase in 25(OH)D levels the associated risk of colorectal cancer decreased by 15 percent, while the risk of breast cancer was associated with an 11 percent decrease. However, when the researchers restricted their analysis to prospective studies only, the breast cancer risk was decreased by only 3 percent, whereas data from case-control studies indicated a risk reduction of 17 percent" - See vitamin D products at iHerb.
• Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma - Int J Cancer. 2011 Mar 15;128(6):1414-24 - "The summary relative risk (SRR) and (95% confidence interval) for a 10 ng/ml increase in serum 25-hydroxyvitamin D was 0.85 (0.79; 0.91) for colorectal cancer (2,630 cases in 9 studies); 0.89 (0.81;0.98) for breast cancer (6,175 cases in 10 studies); and 0.99 (0.95;1.03) for prostate cancer (3,956 cases in 11 studies). For breast cancer, case-control studies (3,030 cases) had major limitations and obtained SRR of 0.83 (0.79; 0.87) whereas SRR of prospective studies (3,145 cases) was 0.97 (0.92; 1.03). For colorectal and breast cancer, differences between cases and controls in the season of blood draw or in overweight/obesity or physical inactivity could not explain the results. In conclusion, a consistent inverse relationship between serum 25-hydroxyvitamin D levels and colorectal cancer was found. No association was found for breast and prostate cancer" - See vitamin D products at iHerb.
• Folate intake and risk of colorectal cancer and adenoma: modification by time - Am J Clin Nutr. 2011 Jan 26
• Chemopreventive Effects of Dietary Canola Oil on Colon Cancer Development - Nutr Cancer. 2011 Jan 24:1 - "Dietary canola oil significantly (P < 0.05) decreased colonic tumor incidence and tumor multiplicity as compared to dietary corn oil in rats. Fatty acid analysis showed that corn oil group had higher levels of ω-6 fatty acid levels, whereas the canola oil groups exhibited higher levels of ω-3 fatty acids from the colon and serum samples of rats. For the mechanistic study, COX-2 expression in the colon samples from the canola oil group was significantly lower (P < 0.05) as compared to the corn oil group. Taken together, dietary canola oil may be chemopreventive for colon tumor development in Fischer rats as compared to possibly by increasing ω-3 fatty acid levels and decreasing COX-2 levels"
• Folic acid and prevention of colorectal adenomas: A combined analysis of randomized clinical trials - Int J Cancer. 2010 Dec 17 - "Observational data suggest that lower folate status is associated with an increased risk of colorectal neoplasia, implying that folate may be useful as a chemopreventive agent. We conducted a combined analysis of three large randomized trials of folic acid supplementation for the prevention of metachronous adenomas in patients with an adenoma history. Participants included 2,632 men and women with a history of adenomas randomized to either 0.5 or 1.0 mg/day of folic acid or placebo, and who had a follow-up endoscopy 6 to 42 months after randomization ... The RR comparing folic acid vs. placebo was 0.98 (95% CI=0.82-1.17) for all adenomas and 1.06 (95% CI=0.81-1.39) for advanced lesions. Folic acid was associated with a non-significant decreased risk of any adenoma among subjects in the lowest quartile of baseline plasma folate (≤11 nmol/L) and no effect among individuals in the highest quartile (>29 nmol/L, p for trend = 0.17). There was a non-significant trend of decreasing risk of any adenoma associated with folic acid supplements with increasing alcohol intake. During the early follow-up reported here, more deaths occurred in the placebo group than in the folic acid group (1.7% vs. 0.5%, p=.002)"
• Designer probiotics could reduce obesity - Science Daily, 12/22/10 - "engineered a strain of Lactobacillus to produce a version of a molecule called conjugated linoleic acid (CLA). When this engineered bacterial strain was fed to mice, the researchers found that the composition of the mice's fat tissue was significantly altered ... One type, called t10, c12 CLA, has been shown to be associated with decreased body fat in humans and other animals. t10, c12 CLA also has the ability to inhibit the growth of colon cancer cells and induce their death. However, this type of CLA is only produced by certain types of bacteria including Propionibacterium acnes -- a skin bacterium that can cause acne ... In this study, an enzyme-encoding gene from P. acnes was transferred to the Lactobacillus strain allowing it to produce t10, c12 CLA ... CLA has already been shown to alleviate non-alcoholic fatty liver disease that often accompanies obesity. Therefore, increasing levels of CLA in the liver by ingestion of a probiotic strain is of therapeutic relevance ... The same group of researchers previously found that microbially produced CLA was able to reduce the viability of colon cancer cells by 92%"
• Dietary Supplementation of Lutein Reduces Colon Carcinogenesis in DMH-Treated Rats by Modulating K-ras, PKB, and β-catenin Proteins - Nutr Cancer. 2010 Dec 2:1 - "The results showed a significant increase in protein expression for K-ras and β-catenin in tumors of DMH-treated rats. Simultaneously, we detected changes in the phosphorylation state of ERK1/2 and PKB in DMH-treated animals. Lutein given in the diet (0.002%), before (prevention) and after (treatment) DMH administration, diminished the number of tumors by 55% and 32%, respectively. Moreover, lutein significantly decreased in tumors the expression of K-ras (25%) and β-catenin (28%) and the amount of pPKB (32%), during the prevention, and 39%, 26%, and 26% during the treatment stage, respectively. This study demonstrates the chemoprotective effect of lutein against colon cancer by modulating the proliferative activity of K-ras, PKB, and β-catenin proteins" - See lutein products at iHerb.
• Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and Colo 205 Tumor Xenografts in Vivo - J Agric Food Chem. 2010 Nov 17 - "capsaicin induced cytotoxic effects in a time- and dose-dependent manner and increased reactive oxygen species (ROS) and Ca(2+) but decreased the level of mitochondrial membrane potential (ΔΨ(m)) in colo 205 cells. Data from Western blotting analysis indicated that the levels of Fas, cytochrome c, and caspases were increased, leading to cell apoptosis. Capsaicin decreased the levels of anti-apoptotic proteins such as Bcl-2 and increased the levels of pro-apoptotic proteins such as Bax. Capsaicin-induced apoptosis in colo 205 cells was also done through the activations of caspase-8, -9 and -3. In vivo studies in immunodeficient nu/nu mice bearing colo 205 tumor xenografts showed that capsaicin effectively inhibited tumor growth. The potent in vitro and in vivo antitumor activities of capsaicin suggest that capsaicin might be developed for the treatment of human colon cancer" - See cayenne products at iHerb.
• NSAIDs cause stem cells to self-destruct, preventing colon cancer, study finds - Science Daily, 11/1/10
• Soy food and isoflavone intake and colorectal cancer risk: the Fukuoka Colorectal Cancer Study - Scand J Gastroenterol. 2010 Oct 24 - "Energy-adjusted intakes of soy foods (dry weight) and isoflavones were inversely associated with colorectal cancer risk in men and postmenopausal women, but not in premenopausal women. The multivariate-adjusted OR for the highest versus lowest quintile was 0.65 (95% CI 0.41-1.03, p for trend = 0.03) for soy foods and 0.68 (95% CI 0.42-1.10, p for trend = 0.051) for isoflavones in men. The corresponding values for postmenopausal women were 0.60 (95% CI 0.29-1.25, p for trend = 0.053) and 0.68 (95% CI 0.33-1.40, p for trend = 0.049)"
• Racial disparity in death from colorectal cancer: does vitamin D deficiency contribute? - Cancer. 2010 Oct 13 - "vitamin D deficiency was associated significantly with CRC mortality (HR, 2.11; 95% CI, 1.11-4.00), and the effect of race was decreased (HR, 1.60" - See vitamin D products at iHerb.
• Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via nrf2 - Nutr Cancer. 2010 Oct;62(7):947-57 - "Treatment with allicin resulted in HCT-116 apoptotic cell death as demonstrated by enhanced hypodiploid DNA content, decreased levels of B-cell non-Hodgkin lymphoma-2 (Bcl-2), increased levels of bax and increased capability of releasing cytochrome c from mitochondria to the cytosol. Allicin also induced translocation of NF-E2-related factor-2 (Nrf2) to the nuclei of HCT-116 cells. Luciferase reporter gene assay showed that allicin induces Nrf2-mediated luciferase transactivation activity. SiRNA knock down of Nrf2 significantly affected the capacity of allicin to inhibit HCT-116 proliferation. These results suggest that Nrf2 mediates the allicin-induced apoptotic death of colon cancer cells" - See garlic products at iHerb.
• Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients - Cancer Res. 2010 Sep 14 - "Consumption of resveratrol reduced tumor cell proliferation by 5% (P = 0.05). The results suggest that daily p.o. doses of resveratrol at 0.5 or 1.0 g produce levels in the human gastrointestinal tract of an order of magnitude sufficient to elicit anticarcinogenic effects. Resveratrol merits further clinical evaluation as a potential colorectal cancer chemopreventive agent" - See resveratrol products at iHerb.
• Even very low dose of regular aspirin wards off bowel cancer, study finds - Science Daily, 9/15/10 - "After a year, taking daily low dose aspirin was associated with a 22% reduced risk of developing bowel cancer, and the magnitude of the reduction in risk was cumulative, rising to 30% after five years ... taking NSAIDs of any kind did not influence the risk of death from any cause nor did it increase bowel cancer survival"
• Plasma vitamins B2, B6, B12, and related genetic variants as predictors of colorectal cancer risk - Cancer Epidemiol Biomarkers Prev. 2010 Sep 2 - "Relative risks (RRs) ... Adjusted RRs comparing the highest to lowest quintile (95% confidence interval, Ptrend) were: 0.71 (0.56-0.91, 0.02) for vitamin B2, 0.68 (0.53-0.87, <0.001) for vitamin B6, and 1.02 (0.80-1.29, 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed >/=30g alcohol/day. The polymorphisms were not associated with CRC ... CONCLUSIONS: Results from this large European cohort study show that higher plasma concentrations of vitamins B2 and B6 are associated with a lower CRC risk"
• Metformin Might Prevent Colorectal, Lung Cancers - Medscape, 9/3/10 - "The chance observation that diabetes patients taking metformin have a 40% reduced risk for cancer triggered intense research interest in this old off-patent drug ... After about 10% of the mouse lifespan — about 12 weeks — with the highest dose in the drinking water, we found a 33% reduction in tumor multiplicity and a 34% reduction in tumor size in the mice. In mice that did not get metformin, 100% got tobacco carcinogen-induced lung tumors ... metformin might prevent tumors by reducing levels of insulin and IGF-1" - See my Insulin and Aging page.  There are a lot of studies pointing toward insulin being a major cause of aging and caner.  See metformin at IAS.
• Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study - Br J Cancer. 2010 Aug 24;103(5):730-4 - "wholegrain (WG) products ... Higher WG product intake was associated with lower risk of colon cancer and rectal cancer in men. The adjusted IRR (95% CI) was 0.85 (0.77-0.94) for colon cancer and 0.90 (0.80-1.01) for rectal cancer per daily 50 g increment in intake. For colon cancer the association was confined to intake of WG bread in particular. No consistent associations between total or individual WG product consumption and colon or rectal cancer risk were observed in women"
• More support for vitamin D’s colorectal protection - Nutra USA, 8/12/10 - "In people using NSAIDs, the potential risk reduction of higher vitamin D levels was increased to 66 per cent" - [Abstract] - See vitamin D products at iHerb.
• Blood 25-Hydroxyvitamin D3 Concentrations and Incident Sporadic Colorectal Adenoma Risk: A Pooled Case-Control Study - Am J Epidemiol. 2010 Jul 22 - "In the pooled analysis, higher circulating 25(OH)D(3) concentrations were statistically significantly associated with decreased colorectal adenoma risk (highest vs. lowest quartile odds ratio = 0.59, 95% confidence interval: 0.41, 0.84). The observed inverse association was stronger among participants who used nonsteroidal antiinflammatory drugs regularly (highest vs. lowest quartile odds ratio = 0.33, 95% confidence interval: 0.19, 0.56). Inverse associations between 25(OH)D(3) and colorectal adenoma did not differ substantially by other risk factors or by adenoma characteristics. These findings support the hypothesis that greater vitamin D exposure may reduce the risk of colorectal adenoma and suggest that it may do so more strongly in combination with antiinflammatory agents" - See vitamin D products at iHerb.
• Nutrient dietary patterns and the risk of colorectal cancer: a case-control study from Italy - Cancer Causes Control. 2010 Aug 1 - "Direct associations were observed between the Starch-rich pattern and both cancer of the colon (OR = 1.68) and of the rectum (OR = 1.74). Inverse relationships were found between the Vitamins and fiber pattern and rectal cancer (OR = 0.61), between the Unsaturated fats (animal source) and the Unsaturated fats (vegetable source) and cancer of the colon (OR = 0.80 and OR = 0.79, respectively) ... The Starch-rich pattern is potentially an unfavorable indicator of risk for both colon and rectal cancer, whereas the Vitamins and fiber pattern is associated with a reduced risk of rectal cancer and the Unsaturated fats patterns with a reduced risk of colon cancer"
• Gut bacteria could be key indicator of colon cancer risk - Science  Daily, 6/29/10 - "a shift in the balance between the "good" bacteria and the "bad" bacteria that populate our gut could be a harbinger of colon cancer ... We think something happens to tip the balance away from the beneficial bacteria and in favor of microbes that make toxic metabolites and are detrimental to our health ... By pinpointing these bacterial culprits, we can not only identify people at risk, but also suggest that they include the good bacteria in their diet .. And what a great way to address colon cancer -- you could know your risk and lower it by eating your yogurt every day" - Note:  Dannon claims that only their Activia brand reaches the gut.  see:
  • Activia by Dannon - "Specialists at Dannon® selected Bifidus Regularis™ for Activia® because it survives passage through the digestive tract, arriving in the colon as a living culture. Once there, it plays a beneficial role in your intestinal ecosystem"
• Associations of red meat, fat, and protein intake with distal colorectal cancer risk - Nutr Cancer. 2010 Aug;62(6):701-9 - "There was no association between total, saturated, or monounsaturated fat and distal CRC risk. In African Americans, the OR of distal CRC for the highest category of polyunsaturated fat intake was 0.28 (95% CI = 0.08-0.96). The percent of energy from protein was associated with a 47% risk reduction in Whites (Q4 OR = 0.53, 95% CI = 0.37-0.77). Red meat consumption in Whites was associated with a marginally significant risk reduction (Q4 OR = 0.66, 95% CI = 0.43-1.00). Our results do not support the hypotheses that fat, protein, and red meat increase the risk of distal CRC"
• Prevention of colorectal cancer with vitamin D - Scand J Gastroenterol. 2010 Apr 5 - "On a molecular level, vitamin D suppresses CRC development and growth by affecting cell proliferation, differentiation, apoptosis, and angiogenesis ... Maintaining serum concentrations of calcidiol above 32 ng/ml (80 nmol/l) in individuals whose serum calcidiol level is low may help prevent CRC as well as osteoporosis, fractures, infections, and cardiovascular disease. Daily calcidiol intake of 1000 International Units can increase serum vitamin D to sufficient levels in most elderly persons and, based on available data, may substantially lower the incidence of CRC with minimal risks" - See vitamin D products at iHerb.
• Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis - Gut. 2010 Mar 26 - "Treatment with EPA-FFA for 6 months was associated with a mean 22.4% (95% CI 5.1% to 39.6%) reduction in polyp number (p=0.012) and a 29.8% (3.6% to 56.1%) decrease in the sum of polyp diameters (p=0.027). Global polyp burden worsened over 6 months in the placebo group (-0.34) unlike the EPA-FFA group (+0.09, difference 0.42 (0.10-0.75), p=0.011) ... EPA-FFA has chemopreventative efficacy in FAP, to a degree similar to that previously observed with selective cyclo-oxygenase-2 inhibitors. EPA holds promise as a colorectal cancer chemoprevention agent with a favourable safety profile" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Vitamin B6 and Risk of Colorectal Cancer: A Meta-analysis of Prospective Studies - JAMA. 2010 Mar 17;303(11):1077-83 - "Omitting 1 study that contributed substantially to the heterogeneity among studies of vitamin B(6) intake yielded a pooled RR of 0.80 (95% CI, 0.69-0.92). The risk of colorectal cancer decreased by 49% for every 100-pmol/mL increase (approximately 2 SDs) in blood PLP levels (RR, 0.51; 95% CI, 0.38-0.69)"
• Omega 3 curbs precancerous growths in those prone to bowel cancer, study suggests - Science Daily, 3/17/10 - "randomly assigned to six months of treatment with 2 g daily of a new highly purified form of the omega 3 polyunsaturated fatty acid (PUFA) EPA. The other 27 were given the same amount of a dummy treatment (placebo) ...number of polyps increased by almost 10% among those treated with the placebo, but fell by more than 12% among those treated with the EPA capsules, representing a difference of almost 22.5% ... Similarly, polyp size increased by more than 17% among those in the placebo group but fell by more than 12.5% in those taking the EPA capsules, representing a difference of just under 30% ... the effects of EPA were similar to those produced by celecoxib, which is used to help curb the growth of new and existing polyps in patients with FAP ... celecoxib has been associated with harmful cardiovascular side effects in older patients" - See See Mega Twin EPA at iHerb.
• Magnesium may decrease colon cancer risk: Study - Nutra USA, 3/15/10 - "Intakes of the mineral of at least 327 milligrams per day were found to reduce the risk of colon cancer by 52 per cent, compared to intakes less than 238 milligrams per day, while no benefits were observed in women" - [Abstract] - See Jarrow Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.
• High Dietary Intake of Magnesium May Decrease Risk of Colorectal Cancer in Japanese Men - J Nutr. 2010 Feb 17 - "When adjusted for potential confounders, the hazard ratio and 95% CI in the highest quintile of magnesium intake compared with the lowest quintile in men were 0.65 (95% CI, 0.40-1.03) for CRC (P-trend = 0.04), 0.48 (95% CI, 0.26-0.89) for colon cancer (P-trend = 0.01), and 0.97 (95% CI, 0.47-2.02) for rectal cancer (P-trend = 0.93)" - See Jarrow Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.
• Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview - Nutr Cancer. 2009 Nov;61(6):842-6 - "Despite the use of surgical resection and aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma develop recurrent disease, highlighting the need for improved therapies. Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma longa) with no discernable toxicity, has been shown to inhibit the growth of transformed cells and colon carcinogenesis at the initiation, promotion, and progression stages in carcinogen-induced rodent models. In a Phase I clinical trial, curcumin has been found to be extremely well tolerated and effective ... Existing data suggest that curcumin in combination with chemotherapy is a superior strategy for treatment of gastrointestinal cancer" - See curcumin/turmeric products at iHerb.
• Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPAR{gamma} - J Nutr. 2010 Jan 20 - "Conjugated linoleic acid (CLA) exerts a protective effect on experimental inflammatory bowel disease and shows promise as a chemopreventive agent against colorectal cancer (CRC) in mice, although the mechanisms by which it exerts its beneficial effects against malignancies in the gut are not completely understood ... Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPARgamma-expressing floxed mice but not in the tissue-specific PPARgamma-null mice. Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Colonic tumor necrosis factor-alpha mRNA expression was significantly suppressed in CLA-fed, PPARgamma-expressing mice. This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPARgamma-dependent mechanism" - See CLA products at iHerb.
• Vitamin D May Lower Colon Cancer Risk - WebMD, 1/22/10 - "They discovered that those with the highest blood levels of vitamin D had a nearly 40% decrease in colorectal cancer risk than those with the lowest levels" - [Science Daily] - See vitamin D products at iHerb.
• Antioxidant compound reduced incidence of colorectal metachronous adenomas - Science Daily, 12/7/09 - "The researchers randomized 411 participants to the placebo group or to receive an antioxidant compound -- specifically selenomethionnine 200 μg, zinc 30 mg, vitamin A 6,000 IU, vitamin C 180 mg and vitamin E 30 mg ... individuals who consumed antioxidants had a 40 percent reduction in the incidence of metachronous adenomas of the large bowel ... It is noteworthy that the benefit observed after the conclusion of the trial persisted through 13 years of follow up"
• Omega-3 fatty acids may reduce risk of colon cancer - Science Daily, 12/7/09 - "Patients who consumed more long-chain omega-3 fatty acids had a reduced risk of distal large bowel cancer. Compared to the lowest quartile, fat intake in the highest quartile was linked with a 39 percent reduced risk of cancer" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Soy component may be key to fighting colon cancer - Science Daily, 11/24/09
• Citrus fruit and cancer risk in a network of case-control studies - Cancer Causes Control. 2009 Oct 24 - "The ORs for the highest versus lowest category of citrus fruit consumption were 0.47 (95% confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI, 0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95% CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal cancer"
• Curcumin synergizes with resveratrol to inhibit colon cancer - Nutr Cancer. 2009;61(4):544-53 - "the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Analysis by Calcusyn software showed synergism between curcumin and resveratrol. The inhibition of tumors in response to curcumin and/or resveratrol was associated with the reduction in proliferation and stimulation of apoptosis accompanied by attenuation of NF-kappaB activity. In vitro studies have further demonstrated that the combinatorial treatment caused a greater inhibition of constitutive activation of EGFR and its family members as well as IGF-1R. Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer"
• Dietary flavonoid intake and colorectal cancer: a case-control study - Br J Nutr. 2009 Sep 7:1-8 - "We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer" - See quercetin products at iHerb.
• Green tea slashes heart disease death - Nutra USA, 9/8/09 - "Compared to people who drank less than one cup a day, seven or more cups of green tea a day may reduce the risk of dying from heart disease by a whopping 75 per cent ... Additionally, a reduction in the risk of colorectal cancer mortality of 31 per cent was observed for people who drank more than seven cups of green a day, compared to people who frank less than three cups a day" - [Abstract] - See Jarrow green tea extract at iHerb.
• Green Tea Consumption and Mortality among Japanese Elderly People: The Prospective Shizuoka Elderly Cohort - Ann Epidemiol. 2009 Oct;19(10):732-739 - "The multivariate HRs and 95% confidence intervals (CIs) for CVD mortality compared those who consumed seven or more cups per day with those who consumed less than one cup per day, were 0.24 (0.14-0.40), 0.30 (0.15-0.61), and 0.18 (0.08-0.40) for total participants, men, and women, respectively. Although green tea consumption was not inversely associated with cancer mortality, green tea consumption and colorectal cancer mortality were inversely associated with a moderate dose-response relationship" - See Jarrow green tea extract at iHerb.
• Natural Compounds, Chemotherapeutic Drugs May Become Partners In Cancer Therapy - Science Daily, 9/7/09 - "New research shows that chlorophyllin -- a water-soluble derivative of chlorophyll, the green pigment found in most plants -- may be 10 times more potent at killing colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancer treatment" - See chlorophyllin products at iHerb.
• Prebiotics may stop early stage colon cancer: Study - Nutra USA, 9/4/09
• More omega-3, less omega-6 for colorectal protection - Nutra USA, 8/12/09 - "the dietary total omega-6 to omega-3 PUFA ratio was strongly associated with colorectal cancer risk ... Compared to women with the lowest ratio, women with the highest ratio of omega-6 to -3 had a relative risk 95 per cent higher" - [Abstract]
• A prospective study of dietary polyunsaturated fatty acids and colorectal cancer risk in Chinese women - Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2283-91 - "The dietary total n-6 to n-3 PUFA ratio was strongly associated with colorectal cancer risk. Compared with women in the lowest quintile group, elevated relative risks (RR) were observed for the second [RR, 1.52; 95% confidence intervals (CI), 1.00-2.32], third (RR, 2.20; 95% CI, 1.41-3.45), fourth (RR, 1.65; 95% CI, 0.99-2.75), and fifth (RR, 1.95; 95% CI, 1.07-3.54) quintile groups. Arachidonic acid was associated with colorectal cancer risk with elevated RRs of 1.20(Q2-Q1) (95% CI, 0.87-1.64), 1.44(Q3-Q1) (95% CI, 1.05-1.98), 1.61(Q4-Q1) (95% CI, 1.17-2.23), and 1.39(Q5-Q1) (95% CI, 0.97-1.99; P(trend) = 0.03) with increasing dietary quintile"
• Aspirin May Help Treat Colon Cancer - WebMD, 8/10/09 - "Certain patients with colorectal cancer who begin regular aspirin use after the disease develops may greatly improve their odds of survival ... Patients with colorectal cancer who started regular aspirin use for the first time after diagnosis had a 47% lower risk of colorectal cancer death and 32% lower risk of overall death than nonusers of aspirin ... The survival advantage was seen only in those with Cox-2-positive tumors. Most colorectal tumors are Cox-2-positive"
• Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model - Int J Cancer. 2009 May 26 - "Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated ... In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31. The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway" - See curcumin/turmeric products at iHerb.
• Understanding The Anticancer Effects Of Vitamin D3 - Science Daily, 7/6/09 - "the active form of vitamin D3 directly activates the CST5 gene in human colon cancer cell lines, increasing levels of cystatin D protein. Functionally, cystatin D was shown to inhibit the growth of human colon cancer cells lines in vitro and when they were xenotransplanted into mice. As knocking down expression of cystatin D in human colon cancer cell lines rendered them unresponsive to the antiproliferative effects of the active form of vitamin D3, the authors conclude that CST5 is a candidate tumor suppressor gene and that it mediates a large proportion of the anticancer effects of the active form of vitamin D3" - See vitamin D products at iHerb.
• Folate linked to lower colorectal cancer risk: Study - Nutra USA, 7/6/09 - "A possible explanation for the contradictory results of studies with the vitamin and colorectal cancer may be the difference between the synthetic and natural forms of the vitamin. “The fact that folic acid, which is not a naturally occurring form of the vitamin, is used by food and pharmaceutical industries for fortification and supplementation is potentially of importance,” wrote Tufts University’s Mason in Nutrition Reviews ... On passage through the intestinal wall, folic acid is converted to 5-methyltetrahydrofolate, the naturally circulating form of folate. However, some studies have suggested that oral doses of folic acid in high doses may overwhelm this conversion pathway, leading to measurable levels of folic acid in the blood ... There has been some concern that this oxidized, non-substituted form of folate might feasibly be detrimental because it is not a naturally occurring co-enzymatic form of the vitamin" - [Abstract]
• Folate intake and the risk of colorectal cancer in a Korean population - Eur J Clin Nutr. 2009 Jun 24 - "Cases were more frequently found to have a family history of CRC among first-degree relatives, to consume more alcohol, to be more likely current smokers and less likely to participate in vigorous physical activity than the controls. In the overall data for men and women combined, multivariate ORs (95% confidence interval (CI), P for trend) comparing the highest vs the lowest quartile of dietary folate intake were: 0.47 (0.32-0.69, < 0.001) for CRC, 0.42 (0.26-0.69, < 0.001) for colon cancer and 0.48 (0.28-0.81, 0.007) for rectal cancer. An inverse association was also found in women with dietary folate intake: 0.36 (0.20-0.64, < 0.001) for CRC, 0.34 (0.16-0.70, 0.001) for colon cancer and 0.30 (0.12-0.74, 0.026) for rectal cancer, but not in men. In addition, the total folate intake of women was strongly associated with a reduced risk of rectal cancer (OR, 0.38; 95% CI, 0.17-0.88; P for trend=0.04). ... We found a statistically significant relationship between higher dietary folate intake and reduced risk of CRC, colon cancer and rectal cancer in women. A significant association is indicated between higher total folate intake and reduced risk of rectal cancer in women"
• Fruit and veg may slash colorectal cancer risk: Study - Nutra USA, 5/11/09 - "Over 8.8 years of follow-up ... the highest average intakes of fruit and vegetables was associated with a 14 per cent reduction in colorectal cancer risk, and a 24 per cent reduction in the risk of colon cancer" - [Abstract]
• Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition - Am J Clin Nutr. 2009 May;89(5):1441-52 - "After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone"
• B6 may slash colorectal cancer risk: Harvard study - Nutra USA, 5/5/09 - "increased intakes of vitamin B6 from dietary and supplements may reduce the risk of colorectal cancer by over 20 per cent (Cancer Epidemiol Biomarkers Prev., Vol. 17, pp. 171-182)"
• Prospective study of plasma vitamin B6 and risk of colorectal cancer in men - Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1197-202 - "plasma PLP levels were significantly inversely associated with risk of colorectal cancer; compared with men in the lowest quartile, those with PLP in quartiles 2 to 4 had relative risks (95% confidence interval) of 0.92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; P(trend) = 0.01), respectively"
• Olive Skins Provide Natural Defense Against Colon Cancer, Study Suggests - Science Daily, 1/8/09
• Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition - Am J Clin Nutr. 2009 Apr 1 - "After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers"
• Prospective Study of Plasma Vitamin B6 and Risk of Colorectal Cancer in Men - Cancer Epidemiol Biomarkers Prev. 2009 Mar 31 - "plasma PLP levels were significantly inversely associated with risk of colorectal cancer; compared with men in the lowest quartile, those with PLP in quartiles 2 to 4 had relative risks (95% confidence interval) of 0.92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; Ptrend = 0.01), respectively. In conclusion, vitamin B6 may protect against colorectal cancer independent of other one-carbon metabolites and inflammatory biomarkers"
• Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells - Int J Cancer. 2009 Jan 13 - "Thus, acetylated derivatives of resveratrol have retained the cytostatic and cytotoxic activities of the parental molecule and thus deserve to be tested as chemosensitizers in animal models" - See Jarrow Resveratrol 100 at iHerb.
• Effects of dietary flaxseed on intestinal tumorigenesis in apc(min) mouse - Nutr Cancer. 2009;61(2):276-83 - "COX-1 and COX-2 expression in the colon samples from the flaxseed meal group were significantly lower (P < 0.05) as compared to the corn meal group. Dietary flaxseed may be chemopreventive for intestinal tumor development in Apc(Min) mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels"
• Selenium, folate, and colon cancer - Nutr Cancer. 2009;61(2):165-78 - "High levels of serum selenium and reported folate jointly were associated with a substantially reduced risk of colon cancer"
• Calcium May Cut Cancer Risk - WebMD, 2/23/09 - "older men and women who got the most calcium from food and supplements had a 16% lower risk of colorectal and other cancers of the digestive system than those who got the least calcium"
• Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model - J Agric Food Chem. 2009 Feb 19 - "Resveratrol increased lactobacilli and bifidobacteria as well as diminished the increase of enterobacteria upon DSS treatment. Resveratrol significantly protected the colonic mucosa architecture, reduced body weight loss, diminished the induced anemia and reduced systemic inflammation markers, colonic mucosa prostaglandin E(2), cycloxygenase-2, prostaglandin E synthase and nitric oxide levels. In addition, the expression of 2,655 genes in distal colon mucosa related to important pathways was varied. These results reinforce the concept of resveratrol as a dietary beneficial compound in intestinal inflammation at doses possibly attainable with resveratrol-enriched nutraceuticals" - See Jarrow Resveratrol 100 at iHerb.
• Cranberry extracts may prevent colon cancer: Lab study - Nutra USA, 2/13/09 - "These findings are important because they demonstrate that the F-κB signalling pathway provides a potential mechanistic link between inflammation and cancer and that the anti-inflammatory properties of crude cranberry extract or quercetin can be used to modulate this pathway" - See Jarrow Formulas, Cran Clearance, 680 mg, 100 Capsules at iHerb.
• People Who Exercise Lower Their Risk Of Colon Cancer - Science Daily, 2/12/09 - "people who exercised the most were 24 percent less likely to develop the disease than those who exercised the least"
• Soy Consumption Linked to Colorectal Cancer Risk in Postmenopausal Women - Medscape, 1/29/09 - "For each 5-g/day increment in dietary intake of soy as measured by dry weight (equivalent to approximately 1 oz [28.35 g] tofu/day), there was an 8% reduction in risk ... Compared with women in the lowest tertile of soy intake, those in the highest tertile had a multivariate relative risk (RR) of 0.67 ... were similar for soy protein and isoflavone intakes"
• Protective Effect of Fish Consumption on Colorectal Cancer Risk. Hospital-Based Case-Control Study in Eastern Europe - Ann Nutr Metab. 2009 Jan 26;53(3-4):295-302 - "The adjusted OR showed a significant reduction in CRC already at the moderate fish intake of one or two servings per week (OR = 0.70; 95% CI: 0.51-0.94), but it was even lower at higher fish intake (OR = 0.56; 95% CI: 0.39-0.86)" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Fruit and Vegetable Intakes Are Associated with Lower Risk of Colorectal Adenomas - J Nutr. 2008 Dec 17 - "The odds ratio for upper tertile intake compared with lower was 0.66 (95% CI = 0.51-0.86) for total fruits, 0.64 (95% CI = 0.47-0.87) for berries, 0.72 (95% CI = 0.56-0.92) for fruit juice, and 0.74 (95% CI = 0.58-0.96) for green vegetables. This study provides additional evidence that high total fruit intake and certain fruit and vegetable intakes may be associated with a reduced risk of colorectal adenomas"
• Vitamin D Can Alter Color Cancer Cells In Many Ways, Through One Pathway - Science Daily, 11/17/08 - "Vitamin D can tame the rogue cell by adjusting everything from its gene expression to its cytoskeleton" - See vitamin D products at iHerb.
• Calcium May Only Protect Against Colorectal Cancer In Presence Of Magnesium - Science Daily, 11/16/08 - "supplementation of calcium only reduced the risk of adenoma recurrence if the ratio of calcium to magnesium was low and remained low during treatment. "The risk of colorectal cancer adenoma recurrence was reduced by 32 percent among those with baseline calcium to magnesium ratio below the median in comparison to no reduction for those above the median"
• Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells - Nutr Cancer. 2008;60 Suppl 1:2-11 - "control colorectal cancer (CRC) ... Grape seed extract (GSE) ... Our results show that irrespective of source, GSE strongly inhibits LoVo, HT29, and SW480 cell growth, with a G1 arrest in LoVo and HT29 cells but an S and/or G2/M arrest in SW480 cell cycle progression. GSE also induced Cip/p21 levels in all 3 cell lines. Furthermore, an induction of apoptosis was observed in all 3 cell lines by GSE. Taken together, our findings suggest that GSE could be an effective CAM agent against CRC possibly due to its strong growth inhibitory and apoptosis-inducing effects" - See OPC + 95 products at iHerb.
• Vitamin D and Prevention of Colorectal Adenoma: A Meta-analysis - Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):2958-69 - "Circulating 25(OH)D was inversely associated with risk of colorectal adenomas: the OR was 0.70 [95% confidence interval (95% CI), 0.56-0.87] for high versus low circulating 25(OH)D. The highest quintile of vitamin D intake was associated with an 11% marginally decreased risk of colorectal adenomas compared with low vitamin D intake (OR, 0.89; 95% CI, 0.78-1.02). For recurrent adenomas, there was a decreased risk of 12% (95% CI, 0.72-1.07) among individuals with high versus low vitamin D intake. The inverse associations appeared stronger for advanced adenoma [OR, 0.64; 95% CI, 0.45-0.90 for serum 25(OH)D and OR, 0.77; 95% CI, 0.63-0.95 for vitamin D intake], but the number of studies was small" - See vitamin D products at iHerb.
• Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study - Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3020-5 - "The incidence of metachronous adenomas at the end-point colonoscopy was 31% (20 of 65) in the control group and 15% (9 of 60) in the GTE group (relative risk, 0.49; 95% confidence interval, 0.24-0.99; P < 0.05). The size of relapsed adenomas was also smaller in the GTE group than in the control group (P < 0.001). No serious adverse events occurred in the GTE group. CONCLUSION: GTE is an effective supplement for the chemoprevention of metachronous colorectal adenomas" - See Jarrow green tea at iHerb.
• Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer - Int J Colorectal Dis. 2008 Oct 2 - "Chemotherapy is associated with a significant increase in the risk of severe vitamin D deficiency. Patients with colorectal cancer, especially those receiving chemotherapy, should be considered for aggressive vitamin D replacement strategies" - See vitamin D products at iHerb.
• Can Fruits, Vegetables Cut Colon Cancer Risk? - WebMD, 9/11/08 - "Based on those answers, the researchers concluded that men who ate the most fruits and vegetables were 26% less likely to develop colorectal cancer than men who ate the least ... No decrease in risk associated with fruit and vegetable consumption was seen for women"
• New Evidence On Folic Acid In Diet And Colon Cancer - Science Daily, 9/1/08 - "folate depletion caused increased DNA damage and a cascade of other biological changes linked to an increased cancer risk" - See folic acid products at iHerb.
• Vitamin D Levels Tied to Colorectal Cancer Survival - Medscape, 7/14/08 - "Compared with patients with the lowest levels, those with the highest had an adjusted hazard ratio of 0.52 for overall mortality" - See vitamin D products at iHerb.
• Vitamin D May Up Colon Cancer Survival - WebMD, 6/18/08 - "patients with colon cancer who were among the top 25% in levels of vitamin D before being diagnosed were less likely to die during the study period than those who were among the 25% with the lowest levels of the vitamin" - [Science Daily] - See 2,500 IU on vitamin D at iHerb
• Glycemic index, glycemic load, and cancer risk: a meta-analysis - Am J Clin Nutr. 2008 Jun;87(6):1793-801 - "Overall, both GL and GI were significantly associated with a greater risk of colorectal (summary RR = 1.26; 95% CI: 1.11, 1.44 and RR = 1.18; 95% CI: 1.05, 1.34, respectively) and endometrial (RR = 1.36; 95% CI: 1.14, 1.62 and RR = 1.22; 95% CI: 1.01, 1.49) cancer than of breast and pancreatic cancer"
• Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer? Results from Model-Based Predictions - Cancer Epidemiol Biomarkers Prev. 2008 Jun 6 - "Changes in colorectal cancer risk in response to folic acid supplementation are likely a complex function of treatment start, duration, and effect on cell proliferation and mutations rates. Predicted colorectal cancer incidence rates under supplementation are mostly higher than rates without folic acid supplementation unless supplementation is initiated early in life (before age 20 years). To the extent to which this model predicts reality, it indicates that the effect on cancer risk when starting folic acid supplementation late in life is small, yet mostly detrimental"
• Resveratrol Induces Apoptosis through ROS-Dependent Mitochondria Pathway in HT-29 Human Colorectal Carcinoma Cells - J Agric Food Chem. 2008 Jun 4 - "Results of the present study provide evidence demonstrating the antitumor effect of trans-resveratrol via a ROS-dependent apoptosis pathway in colorectal carcinoma" - See Jarrow Resveratrol 100 at iHerb.
• Effects of aqueous green tea extract on activities of DNA turn-over enzymes in cancerous and non-cancerous human gastric and colon tissues - Altern Ther Health Med. 2008 May-Jun;14(3):30-3 - "Our data suggest that green tea may support the medical treatment of stomach and colon cancer" - See Jarrow green tea at iHerb.
• Omega-3 linked to lower colorectal cancer risk - Nutra USA, 5/16/08 - "In terms of fish intake, the highest average intake was associated with a 40 per cent reduction in the risk of colorectal cancer. In addition, this link was relevant for both colon and rectal cancers" - See Mega Twin EPA at iHerb.
• A 22-year Prospective Study of Fish, n-3 Fatty Acid Intake, and Colorectal Cancer Risk in Men - Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1136-43 - "Fish intake was inversely associated with colorectal cancer risk [multivariate relative risk (95% confidence interval) for highest versus lowest category, 0.60 (0.40-0.91); P(trend) = 0.01]. The inverse association was observed for both colon and rectal cancers. Our findings for n-3 fatty acids were similar to those for fish; the multivariate relative risk (95% confidence interval) of total colorectal cancer for the highest versus lowest quartile of n-3 fatty acids was 0.74 (0.57-0.95; P(trend) = 0.01) ... Our results from this long-term prospective study suggest that intakes of fish and long-chain n-3 fatty acids from fish may decrease the risk for colorectal cancer" - See Mega Twin EPA at iHerb.
• Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients - World J Gastroenterol. 2008 Apr 21;14(15):2434-2439 - "Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 +/- 4.80 d vs 19.62 +/- 5.59 d, P = 0.19) ... Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response" - See Mega Twin EPA at iHerb.
• Vitamin D And Calcium Influence Cell Death In The Colon, Researchers Find - Science Daily, 4/13/08 - "We were pleased that the effects of calcium and vitamin D were visible enough in this small study to be significant and reportable"
• Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial - Cancer Causes Control. 2008 Mar 6 - "Low dietary folate intake has been associated with colorectal cancer risk and adenoma recurrence. A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk ... In general, no statistically significant associations were found between quartile of folate intake (dietary or total) and adenoma recurrence ... No significant interaction was noted for total folate and MTHFR genotype, though an increased risk of recurrence noted for the MTHFR CT genotype was statistically significant only for those individuals with below median intake of total folate"
• Aspirin Associated With Reduced Colorectal Cancer Risk in Men - Medscape, 2/12/08 - "men who reported regular aspirin use (at least 2 times per week) had a significantly lower risk of colorectal cancer compared with those who were not regular aspirin users (multivariate RR, 0.79) ... However, men reporting 6 to 14 standard aspirin tablets per week had a multivariate RR of 0.72, and those consuming more than 14 tablets per week experienced a multivariate RR of 0.30" - Note: A RR of 0.79 is a 21% reduction, a RR of 0.30 is a 70% reduction.
• Vitamin D Appears to Cut Breast and Colorectal Cancer Risk - Medscape, 2/12/08 - "Compared with a serum 25-hydroxyvitamin D level less than 12 ng/mL, a level of at least 33 ng/mL or more was associated with a 50% reduction in the risk for incident colorectal cancer ... vitamin D intake of 1000 to 2000 IU per day would confer an appropriate balance between protection against colorectal cancer and adverse events related to hypervitaminosis" - See vitamin D products at iHerb.
• Regular, Long-Term Aspirin Use Reduces Risk of Colorectal Cancer - Doctor's Guide, 1/23/08 - "the benefit of aspirin was not apparent until after more than five years of use. The greatest reduction in risk was observed at cumulative doses of more than 14 standard tablets (325 mg) per week, which is higher than normally recommended. The benefit of aspirin use appears to diminish less than four years after stopping use and is not evident after four to five years of discontinued use"
• Recreational Physical Activity and Cancer Risk in Subsites of the Colon (the Nord-Trondelag Health Study) - Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):183-8 - "Overall, we found an inverse association between recreational physical activity and colon cancer risk, but subsite analyses showed that the association was confined to cancer in the transverse and sigmoid colon. The adjusted HR, comparing people who reported high versus no physical activity, was 0.44 (95% CI, 0.25-0.78) for cancer in the transverse colon and 0.48 (95% CI, 0.31-0.75) for cancer in the sigmoid colon. The corresponding HR for cancer mortality was 0.33 (95% CI, 0.14-0.76) for the transverse colon and 0.29 (95% CI, 0.15-0.56) for the sigmoid colon. For rectal cancer, there was no association with physical activity in these data"
• Vitamin B6 may slash colorectal cancer risk - Nutra USA, 1/17/08 - "High vitamin B6 intakes were reported to reduce the risk of colorectal cancer by 19 per cent. The protective effect was found to be higher among 55-year-old individuals (1,001 cases compared to 1,010 controls)" - [Abstract]
• Dietary vitamin b6 intake and the risk of colorectal cancer - Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82 - "Moderately strong inverse and dose-dependent associations in the whole sample were found between CRC risk and the intake of dietary and total vitamin B6 in all three models [model III: odds ratio (OR), 0.77; 95% confidence interval (95% CI), 0.61-0.98; P for trend = 0.03; OR, 0.86; 95% CI, 0.69-1.07; P for trend = 0.12]. In addition, meta-analyses of published studies showed inverse associations between vitamin B6 and CRC (combined relative risk, 0.81; 95% CI, 0.68-0.96; test for overall effect P = 0.01; combined odds ratio, 0.67; 95% CI, 0.60-0.75; test for overall effect P < 0.00001)"
• Childhood Dairy Intake Linked to Colon Cancer - oncologystat.com, 12/19/07 - "Those who reported high levels of dairy during childhood were about 3 times more likely to develop colon cancer than those with low intake. A high intake was considered 2 or more cups a day, with a low intake being half a cup or less"
• Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort - Am J Clin Nutr. 2007 Dec;86(6):1722-9 - "High childhood total dairy intake was associated with a near-tripling in the odds of colorectal cancer [multivariate odds ratio: 2.90 (95% CI: 1.26, 6.65); 2-sided P for trend = 0.005] compared with low intake, independent of meat, fruit, and vegetable intakes and socioeconomic indicators"
• Elevated Insulin, Glucose Raise Risk of Polyp Recurrence - Medscape, 12/10/07 - "patients with elevated insulin or glucose at the time of adenoma removal are at increased risk for recurrent adenoma ... Levels of glucose that produced the increased risk in this study were actually not very high, 99 mg/dL, which is right at the border of what we would describe as impaired fasting glucose ... the odds ratio for a recurrent polyp with advanced histology or large size was 2.43 at a fasting glucose level above 99 mg/dL ... These results "fit with the theory that insulin resistance, hyperinsulinemia, and hyperglycemia promote the development of colorectal neoplasia,""
• Chemoprevention, Naturally: Findings On Plant-derived Cancer Medicines - Science Daily, 12/6/07 - "rats fed a diet containing Polyphenon E, a standardized green tea polyphenol preparation, are less than half as likely to develop colon cancer ... After 34 weeks, rats that received Polyphenon E developed 55 percent fewer tumors compared to the control rats that did not receive Polyphenon E. Moreover, the tumors were 45 percent smaller in rats treated with green tea extract" - See Jarrow green tea at iHerb.
• Aspirin and Folic Acid for the Prevention of Recurrent Colorectal Adenomas - Gastroenterology. 2007 Oct 10 - "In total, 99 (22.8%) of 434 patients receiving aspirin had a recurrent adenoma compared with 121 (28.9%) of 419 patients receiving placebo (relative risk, 0.79"
• Grape Powder Blocks Genes Linked To Colon Cancer - Science Daily, 11/14/07 - "The Wnt pathway has been linked to more than 85 percent of sporadic colon cancers, which is the most common form of colon cancer ... Wnt signaling in the patients taking 80 grams of grape powder was significantly reduced ... Eighty grams of grape powder equal a half glass of wine or 1 pound of grapes, which is equivalent to three dietary servings of grapes, according to the USDA"
• Riboflavin boosts folate's colorectal cancer protection - study - Nutra USA, 10/29/07
• Mesalamine, Folic Acid Each Cut Colorectal Cancer in Patients With Inflammatory Bowel Disease - oncologystat.com, 10/24/07 - "Patients who took at least 1 mg of folic acid daily also had about a 90% cut in their CRC incidence during follow-up, compared with the controls" - See iHerb folic acid products.
• Omega-3 to cut colon cancer: meta-analysis - Nutra USA, 10/25/07 - "the highest consumption of fish oil was associated with 12 per cent reduction in the incidence of colorectal cancer" - [Abstract] - See Mega Twin EPA at iHerb.
• Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line - Cancer Lett. 2007 Oct 6 - "grape seed proanthocyanidin extract (GSPE) ... GSPE (10-100mug/ml) significantly inhibited cell viability and increased apoptosis in CaCo2 cells, but did not alter viability in the normal colon cell line (NCM460). The increased apoptosis observed in GSPE-treated CaCo2 cells correlated with an attenuation of PI3-kinase (p110 and p85 subunits) and decreased PKB Ser(473) phosphorylation. GSPE might thus exert its beneficial effects by means of increased apoptosis and suppression of the important PI3-kinase survival-related pathway" - See grape seed products at iHerb.
• Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R - Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer" - See curcumin/turmeric products at iHerb.
• Fruits, Veggies Don’t Cut Colon Cancer - WebMD, 9/25/07 - "Overall, a higher intake of fruits and vegetables does not strongly reduce your risk of colon cancer"
• CLA isomers show promise against colon cancer - study - Nutra USA, 9/24/07 - "We have demonstrated that diets containing 0.1 per cent c9,t11 and t10,c12 CLA were equally effective in inhibiting colon cancer cell metastasis in vivo" - See CLA products at iHerb.
• Influence of conjugated linoleic acid isomers on the metastasis of colon cancer cells in vitro and in vivo - J Nutr Biochem. 2007 Oct;18(10):650-7 - "diets containing 0.1% c9,t11 and t10,c12 CLA were equally effective in inhibiting colon cancer cell metastasis in vivo. However, in vitro, only c9,t11 but not t10,c12 inhibited colon cancer cell migration and MMP-9 activity" - See CLA products at iHerb.
• Vitamin D for Cancer Prevention? - WebMD, 9/5/07 - "The 2,000-IU daily dose of vitamin D suggested by the reviewers is currently considered the "tolerable upper limit" for vitamin D ... a projected 50% reduction in colon cancer incidence would require a universal intake of 2,000 IU per day of vitamin D3 ... A similar reduction in breast cancer incidence would require 3,500 IU per day"
• Study Shines More Light On Benefit Of Vitamin D In Fighting Cancer - Science Daily, 8/21/07 - "For the first time, we are saying that 600,000 cases of breast and colorectal cancer could be prevented each year worldwide, including nearly 150,000 in the United States alone ... The serum level recommended by the study would correspond to intake of 2000 International Units per day of vitamin D3 for a meaningful reduction in colorectal cancer" - See vitamin D products at iHerb.
• Colon Cancer on curcumin and Vectibix - Johns Hopkins, 8/14/07 - "University of Texas researchers treated some human colorectal cancer cells with neurotensin, with and without curcumin. They confirmed that neurotensin started a chain reaction of chemicals that can increase the growth of cancer and also the migration of cancer cells and that curcumin blocked the process ... Curcumin appears to do this by blocking the biochemical signals sent by neurotensin that contribute to colon cancer cell growth and migration (the spread of cancer to other body sites)" - See curcumin/turmeric products at iHerb.
• Inhibition Of Tumorigenesis in Apc(Min/+) Mice by a Combination of (-)-Epigallocatechin-3-gallate and Fish Oil - J Agric Food Chem. 2007 Aug 16 - "The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in Apc (Min/+) mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups" - See Mega Twin EPA at iHerb and Jarrow green tea at iHerb.
• Compounds That Color Fruits And Veggies May Protect Against Colon Cancer - Science Daily, 8/19/07 - "In animal studies, rats induced with colon cancer cells were fed a daily diet of anthocyanin extracts either from bilberries and chokeberries, which are most often used as flavorings or to make jams and juices. The dietary addition of the anthocyanin extracts reduced signs of colon tumors by 70 and 60 percent, respectively, when compared to control rats"
• Green tea may stop colon cancer in its tracks - study - Nutra USA, 8/9/07 - "At the age of eight weeks, the mice were divided into two groups - one to receive water or a green tea solution (0.6 per cent) as the only beverage source for a further four to eight weeks ... consumption of the green tea solution significantly inhibited the formation of new tumours in the colon" - See Jarrow green tea at iHerb.
• Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model - Carcinogenesis. 2007 Jul 17 - "green tea specifically targets initial stages of colon carcinogenesis; the time of administration of green tea is pivotal for effective chemoprevention. Beverage levels of GT are not likely to inhibit the progress of any large adenomas or adenocarcinomas existing prior to the tea administration"
• A Nested Case-Control Study of Plasma 25-Hydroxyvitamin D Concentrations and Risk of Colorectal Cancer - J Natl Cancer Inst. 2007 Jul 10 - "Our data provide additional support for the inverse association between vitamin D and colorectal and, in particular, colon cancer risk"
• Mistletoe in Supportive Care for Colorectal and Pancreatic Cancers - Doctor's Guide, 7/12/07 - "Use of a fermented mistletoe extract (MEx; Iscador®) in long-term supportive care in hospitals and private practices demonstrated significant survival benefit and improvements in quality of life for patients with surgically treated primary, nonmetastatic colorectal carcinoma and for patients with all-stages pancreatic carcinoma, when combined with adjuvant chemotherapy and/or radiotherapy or passive aftercare in two multicentre, controlled, retrospective, epidemiological, observational, cohort studies"
• A Nested Case-Control Study of Plasma 25-Hydroxyvitamin D Concentrations and Risk of Colorectal Cancer - J Natl Cancer Inst. 2007 Jul 10 - "we observed a non-statistically significant inverse association between higher plasma 25(OH)D concentration and risk of colorectal cancer and a statistically significant inverse association for colon cancer (highest versus lowest quintile: odds ratio [OR] = 0.46, 95% confidence interval [CI] = 0.24 to 0.89; P(trend) = .005). After pooling the results from the HPFS and NHS, higher plasma 25(OH)D concentrations were statistically significantly associated with decreased risks of both colorectal cancer (highest versus lowest quintile, OR = 0.66, 95% CI = 0.42 to 1.05; P(trend) = .01) and colon cancer (highest versus lowest quintile, OR = 0.54" - See vitamin D products at iHerb.
• Different omega-3 may offer different colorectal protection - Nutra USA, 7/11/07 - "Increased intake of EPA was associated with a 41 per cent reduction in risk, while DHA was associated with a 37 per cent reduction in risk, comparing highest against lowest average intakes" - [Abstract] - See Mega Twin EPA at iHerb.
• Dietary Fatty acids and colorectal cancer: a case-control study - Am J Epidemiol. 2007 Jul 15;166(2):181-95 - "Significant dose-dependent reductions in risk were associated with increased consumption of omega-3 polyunsaturated fatty acids (highest vs. lowest quartile of intake: odds ratio = 0.63, 95% confidence interval: 0.50, 0.80; p < 0.0005 for trend) and of eicosapentaenoic (odds ratio = 0.59, 95% confidence interval: 0.47, 0.75; p < 0.0005 for trend) and docosahexaenoic (odds ratio = 0.63" - See Mega Twin EPA at iHerb.
• Vitamin D Fights Colon Cancer - WebMD, 7/10/07 - "The findings support a number of previous studies that link vitamin D to colon cancer protection, to protection against breast and ovarian cancer, to protection against pancreatic cancer, and to overall reduction of cancer risk" - See vitamin D products at iHerb.
• Low Intake of Vitamin B-6 Is Associated with Increased Risk of Colorectal Cancer in Japanese Men - J Nutr. 2007 Jul;137(7):1808-1814 - "We observed a significant inverse association between vitamin B-6 intake and colorectal cancer in men. Compared with the lowest quartile, the multivariate hazard ratio (95% [CI]) in the highest quartile of intake was 0.69"
• Dietary fiber and colorectal cancer risk: the multiethnic cohort study - Cancer Causes Control. 2007 Jun 8 - "Dietary fiber was inversely associated with colorectal cancer risk in men, but its relation to replacement hormone use and other factors affected its inverse association in women"
• Prospective cohort study of green tea consumption and colorectal cancer risk in women - Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1219-23 - "The multivariate relative risk of CRC was 0.63 (95% confidence interval, 0.45-0.88) for women who reported drinking green tea regularly at baseline compared with nonregular tea drinkers" - I read that as a 37% reduction in risk.  See Jarrow green tea at iHerb. - Ben
• Diet May Influence Survival After Treatment For Stage III Colon Cancer, Study Suggests - Science Daily, 6/4/07
• Life Long Vegetarian Diet Reduces The Risk Of Colorectal Cancer - Science Daily, 5/22/07 - "a vegetarian diet is associated with reduced risk of CRC if started very early in life"
• Aspirin May Stop Colon Cancer - WebMD, 5/10/07 - "people who took a full-dose aspirin tablet every day for at least five years had as much as a 74% lower risk of colon cancer 10 to 14 years later. In the U.S."
• Curcumin for chemoprevention of colon cancer - Cancer Lett. 2007 Apr 18 - "Overwhelming in vitro evidence and completed clinical trials suggests that curcumin may prove to be useful for the chemoprevention of colon cancer in humans" - See curcumin/turmeric products at iHerb.
• Coffee consumption and risk of colorectal cancer in a population-based prospective cohort of Japanese men and women - Int J Cancer. 2007 Apr 20 - "We observed a significant inverse association between coffee consumption and the risk of developing invasive colon cancer among women. Compared with those who almost never consumed coffee, women who regularly consumed 3 or more cups of coffee per day had a RR of 0.44 ... In men, no significant decrease was observed in any colorectal cancer site"
• Berries May Help Prevent Cancer - WebMD, 3/26/07
• Blueberries tackle bowel cancer - BBC News, 3/26/07 - "The key ingredient, pterostilbene, is a natural antioxidant and mops up highly reactive molecules called free radicals that can trigger cancer growth ... Rats given a cancer-causing agent but then fed pterostilbene had far fewer pre-cancers in their bowels than other rats ... The blueberry compound also reduced inflammation and the rate of cell division in the bowel"
• Fruit May Sway Colon Cancer Risk - WebMD, 3/20/07 - "The group that had the lowest risk of having an adenoma was the group that ate a lot of fruit and avoided meat, basically"
• Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study - Br J Cancer. 2007 Feb 12;96(3):510-3 - "Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake"
• Vitamin D Backed For Cancer Prevention In Two New Studies - Science Daily, 2/8/07 - "Two new vitamin D studies using a sophisticated form of analysis called meta-analysis, in which data from multiple reports is combined, have revealed new prescriptions for possibly preventing up to half of the cases of breast cancer and two-thirds of the cases of colorectal cancer in the United States ... The serum level associated with a 50 percent reduction in risk could be maintained by taking 2,000 international units of vitamin D3 daily plus, when the weather permits, spending 10 to 15 minutes a day in the sun" - See Vitamin D products at iHerb.
• Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial - J Natl Cancer Inst. 2007 Jan 17;99(2):129-36 - "placebo or 1200 mg of elemental calcium daily for 4 years ... During the first 5 years after randomized treatment ended, subjects in the calcium group still had a substantially and statistically significantly lower risk of any adenoma than those in the placebo group (31.5% versus 43.2%"
• Calcium May Reduce Colon Cancer Risk - WebMD, 1/16/07 - "Patients with a history of nonmalignant polyps took either 1,200 milligrams of calcium in supplement form or a placebo daily for four years ... Calcium use was associated with a 17% lower relative risk for polyp recurrence"
• Colorectal cancer protective effects and the dietary micronutrients folate, methionine, vitamins b6, B12, C, e, selenium, and lycopene - Nutr Cancer. 2006;56(1):11-21 - "a diet containing the dietary micronutrients involved in DNA methylation (folate, methionine, and vitamins B6 and B12) and some of those with antioxidant properties (selenium and vitamins E and C) may have a role to play in lowering colorectal cancer risk and also that such protection can be achieved by dietary means alone"
• More support omega-3 may protect against colorectal cancer - Nutra USA, 11/22/06 - "A diet rich in omega-3 polyunsaturated fatty acids (PUFAs) could reduce the risk of colorectal cancer by 85 per cent"
• Low Folate Diets Found To Increase Risk Of Colorectal Cancer - Science Daily, 11/14/06 - "None of the mice fed a control diet developed tumours whereas 1 in 4 mice on the folate-deficient diet developed at least one tumour"
• Soy, Fish May Cut Cancer Risk - WebMD, 11/14/06 - "men who ate the most fish -- and that was five or more servings per week of fish -- compared to the least fish -- less than one time per week -- had a 40% lower risk of developing colorectal cancer"
• Calcium again linked to lower colorectal cancer risk - Nutra USA, 11/8/06 - "the relative risk of colorectal cancer for the highest calcium intake group was 40 per cent lower compared to the lowest intake group"
• Grape Seed Extract Halts Cell Cycle, Checking Growth Of Colorectal Tumors In Mice - Science Daily, 10/29/06 - "documented a 44 percent reduction of advanced colorectal tumors in the animals, and also revealed, for the first time, the molecular mechanism by which grape seed extract works to inhibit cancer growth" - See iHerb or Vitacost grape seed extracts.
• Red Wine vs. Colon Cancer - WebMD, 10/24/06 - "3% of red wine drinkers had such abnormal growths, compared with nearly 9% of white wine drinkers and almost 10% of teetotalers ... they suggest that a compound found in grapes and red wine – the antioxidant resveratrol -- may cut the odds of getting abnormal colon growths that can become cancerous"
• Resveratrol in red wine could cut colorectal cancer risk - Nutra USA, 10/23/06 - "Drinking more than three glasses of red wine a week could cut the risk of colorectal cancer by almost 70 per cent ... the active component in wine that may be behind the apparent benefits is most likely resveratrol"
• Grape Seed Extract vs. Colon Cancer - WebMD, 10/19/06 - "The cancer cells treated with grape seed extract were more likely to halt their normal growth cycle and die, compared to those not treated with the extract"
• Flavonoids linked to colorectal cancer protection - Nutra USA, 8/9/06 - "A diet rich in certain flavonoids, from eating plenty of fruit and vegetables, could reduce the risk of colorectal cancer by over 40 per cent, says a large observational study from Italy"
• Chemical in Curry May Cut Colon Cancer - WebMD, 8/2/06 - "Each of the patients then received 480 milligrams of curcumin and 20 milligrams of quercetin three times a day for six months ... The results showed that treatment with the curry and onion compounds reduced the average number of polyps by 60%, and decreased their size by 50%" - See iHerb or Vitacost curcumin products and iHerb or Vitacost quercetin products.
• Moderate Exercise Improves Survival Rates For Colon Cancer Survivors - Science Daily, 7/14/06
• Vitamin B6 May Help Prevent Colorectal Cancer - Medscape, 6/10/06 - "There was an inverse association between vitamin B6 intake and colorectal cancer, with the relative risk (RR) for the highest quintile vs the lowest quintile being 0.66 ... Vitamin B6 may have a role in colorectal cancer prevention through reduction of oxidative stress and synthesis of a form of folate required for DNA repair, synthesis, and methylation"
• Moderate Alcohol Consumption Protects Against Colorectal Adenoma - Doctor's Guide, 5/24/06 - "Non-drinkers had a 40% higher risk of adenoma than those in the moderate (1-2 drinks and 2-6 drinks per week) groups. Those drinking 7 or more alcoholic beverages per week had 150% higher risk of adenoma than the moderate groups"
• Lowering Colon Cancer Risk? - Dr. Weil, 5/2/06
• More support that dairy could reduce colorectal cancer risk - Nutra USA, 3/8/06 - "A diet rich in dairy products could cut the risk of colorectal cancer by half, an effect that is not due solely to calcium"
• More support for magnesium against colon cancer - Nutra USA, 1/31/06 - "The hazard ratio, a measure of the risk, was statistically 25 per cent lower for the volunteers with the highest intake of magnesium (more than 356 mg per day)"
• Epidemiology of Vitamin D and Colorectal Cancer: Recent Findings - Medscape, 1/9/06 - "In vitro, animal and clinical studies strongly indicate that vitamin D may have anticancer benefits, including against progression (such as metastasis) in colorectal cancer and possibly other cancers. Thus improving vitamin D status could be potentially beneficial against either incidence or mortality, or both ... Current recommended intakes of vitamin D (for example, 400 IU/day) may be too low to provide maximal benefits, though the precise optimal dose remains unestablished"
• High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort - Am J Clin Nutr. 2005 Oct;82(4):894-900 - "For CLA, the multivariate rate ratio of colorectal cancer in a comparison of the 2 extreme quartiles of intake was 0.71 ... These prospective data suggest that high intakes of high-fat dairy foods and CLA may reduce the risk of colorectal cancer" - [Food Navigator]
• Selenium supplementation and colorectal adenomas: An analysis of the nutritional prevention of cancer trial - Int J Cancer. 2005 Oct 10 - "In addition to being associated with a reduced risk of incident CRC [colorectal cancers], selenium supplementation was associated with a significantly reduced risk of prevalent adenomas, but only among subjects with either a low baseline selenium level or among current smokers" - See iHerb or Vitacost selenium products.
• High-Dose Aspirin Prevents Colon Cancer - WebMD, 8/23/05
• Long-Term, Regular Aspirin Use Associated With Significant Reduction in Colorectal Cancer Risk Among Women - Doctor's Guide, 8/23/05 - "Among women who regularly used aspirin (2 or more standard [325-mg] tablets per week), there was a 23% reduced relative risk for colorectal cancer compared with nonregular users. However, significant risk reduction was not observed until more than 10 years of use"
• Calcium Supplements May Help Prevent Polyps - WebMD, 7/19/05 - "people who took calcium had about a 25% lower risk of developing polyps in their colon"
• Fish may protect against colorectal cancer - Nutra USA, 6/15/05 - "People eating less than 14g of fish a day were 40 per cent more likely to develop the cancer than those eating more than 50g per day"
• Vitamin B6 May Help Prevent Colorectal Cancer - Medscape, 6/10/05 - "those in the highest quintile had a 34% lower risk of colorectal cancer (multivariate rate ratio"
• High vitamin B intake cuts risk of colorectal cancer - Nutra USA, 6/6/05
• Preventing Colon Cancer? - Dr. Weil, 5/26/05
• Moderate Exercise Reduces Risk of Colon Cancer Recurrence - Doctor's Guide, 5/20/05 - "disease-free survival was 49% lower in patients who engaged in 18 to 27 MET-hours/week of physical activity, compared with those who exercised less than 3 MET-hours/week. "This is equivalent to a 2 to 3 mph walk a day, 6 days a week, running fast 2 times a week or playing tennis 3 a week,""
• Aspirin May Prevent Colon Cancer Recurrence - Doctor's Guide, 5/20/05 - "Recurrence-free survival was 55% lower in aspirin users than non-users (95% CI, 0.21-0.96), disease-free-survival was 54% lower (95% CI 0.23-0.95), and overall survival was 51% lower"
• Exercise May Cut Risk of Colon Cancer's Return - WebMD, 5/17/05
• Aspirin, COX-2 Inhibitors Effective as Adjuvant Therapy in Stage III Colon - Medscape, 5/16/05 - "The chemotherapy provides about 35% improvement in survival compared with surgery alone for that stage of colon cancer, Dr. Fuchs said in an interview. In comparison, aspirin or the two cyclooxygenase 2 (COX-2) inhibitors produced a reduction in risk of recurrence and death that was about 50% beyond what was achieved by chemotherapy after surgery"
• Aspirin Prevents Colon Cancer Return - WebMD, 5/16/05
• Vitamin B-6 May Help People Avoid Colon Cancer - WebMD, 5/3/05 - "The risk of colorectal cancer was 44% lower for the women with the highest blood level of vitamin B-6 compared with women with the lowest level of vitamin B-6"
• Calcium Supplements Keep on Working Even After They Are Stopped - Doctor's Guide, 4/21/05 - "People at high risk of colon cancer appear to reduce the risk of developing polyps while taking calcium supplements and continue to benefit for as long as 5 years after they stop taking them"
• Statins Lower Prostate Cancer Risk - WebMD, 4/18/05 - "long-term use of calcium supplements protects against the development of potentially precancerous colon polyps for years after you stop taking them"
• Calcium May Help Prevent Colorectal Cancer - WebMD, 1/28/05
• Magnesium intake in relation to risk of colorectal cancer in women - JAMA. 2005 Jan 5;293(1):86-9 - "a high magnesium intake may reduce the occurrence of colorectal cancer in women"
• Selenium May Lower Colon Cancer Risk - WebMD, 11/16/04 - "participants with the highest blood levels of selenium were 34% less likely to develop a new adenoma compared with those with the lowest selenium blood levels"
• Milk, Calcium, May Cut Colon Cancer Risk - WebMD, 7/6/04
• Calcium More Protective Against Some Polyps - WebMD, 6/15/04 - "The calcium group had 18% fewer noncancerous polyps and 35% fewer advanced polyps ... compared with the placebo group ... her study suggests that total calcium intake over 1,200 mg daily is necessary for colon protection -- and that a high-fiber diet with modest levels of fat will boost the protective effects"
• New findings on soy and cancer prevention - Nutra USA, 5/13/04
• Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence - Am J Clin Nutr. 2004 Apr;79(4):691-697 - "A lower recurrence of colorectal adenomas was shown in subjects with higher intakes and plasma concentrations of folate. Additional markers involved in folate metabolism, including lower homocysteine and higher vitamin B-6 intake, were also associated with lower odds of recurrence"
• Heme Iron and Zinc Have Opposite Effects on Colon Cancer Risk - Doctor's Guide, 3/29/04 - "heme iron appears to raise the risk of proximal colon cancer while dietary zinc appears to lower the risk of both proximal and distal colon cancer"
• 5 a day force, new evidence - Nutra USA, 2/11/04 - "High intakes of vegetables, fruits and wholegrain foods reduces the risk of rectal cancer by 28 per cent, 27 per cent and 31 per cent, respectively ... High fiber diet – more that 34 grammes a day reduced risk of rectal cancer by a staggering 66 per cent"
• Aspirin Use May Prevent Colon Cancer - WebMD, 2/2/04 - "Regularly taking aspirin -- more than two tablets a week -- reduced the risks of polyps by 25% ... while higher doses of aspirin (325 milligrams per day) may be necessary for optimal prevention of polyps, the risk of severe gastrointestinal bleeding remains a serious concern" - See Drugstore.com aspirin products.
• Effect of an omega-3 fatty acid containing lipid emulsion alone and in combination with 5-fluorouracil (5-FU) on growth of the colon cancer cell line Caco-2 - Eur J Nutr. 2003 Dec;42(6):324-31 - "FO has a potent antiproliferative effect on Caco-2 cells"
• Diet, lifestyle may lower colon cancer risk - MSNBC, 1/23/04 - "One prime suspect now is insulin resistance. In this condition, higher levels of insulin circulate because the body is less responsive to it. Insulin and related growth factors seem to change cell processes in ways that promote the development of cancer"
• Lycopene, ß-carotene, and colorectal adenomas -Am  J  of Clin Nutr, Vol. 78, No. 6, 1219-1224, 12/03 - "Our findings support the hypothesis that lycopene contributes to the protective effect of high tomato intakes against the risk of colorectal adenomas"
• What Causes, Prevents Colon Polyps - WebMD, 12/9/03 - "Just take an aspirin, a multivitamin, and eat a bowl of fiber-packed cereal with some milk ... In this new report, vitamin D shines -- it's associated with a one-third reduced risk of serious colon polyps that often lead to cancer in men getting at least 645 IUs of this nutrient each day"
• Calcium And Vitamin D Collaborate To Reduce Colorectal Cancer Risk - Intelihealth, 12/3/03
• Calcium Intake Plus Vitamin D May Protect Against Colon Adenomas - Medscape, 12/2/03 - "Calcium supplementation reduces the rate of colon adenomas, but only if vitamin D levels are adequate"
• Studies Associate Fish And Multivitamins With Reduced Risk For Colorectal Cancer - Doctor's Guide, 7/16/03 - "Only fish consumption was associated with a reduction in risk ... Both processed meat and red meat consumption were associated with increased risk ... Duration of multivitamin use was associated with a decreased risk of rectal cancer"
• An Aspirin a Day Does Not Reduce Colorectal Cancer Risk Among Smokers - Doctor's Guide, 7/16/03
• Night Shifts May Raise Cancer Risk - WebMD, 6/3/03 - "Data from an ongoing study of almost 80,000 nurses already suggest that working nights increases a woman's risk of breast cancer ... a new analysis points to a similar association for colorectal cancer ... "The peak production of melatonin occurs at about 1 or 2 a.m." Exposure to light at night stops the production of melatonin" - See iHerb or Vitacost melatonin products.
• 2 Studies Contradict Earlier Research Showing No Benefit of Fiber on Colon Cancer Risk - WebMD, 5/1/03 - "What's more consistent is the two newest findings, both published in the May 3 issue of The Lancet ... those eating a high-fiber diet -- upwards of 36 grams of fiber each day -- were 25% less likely to develop polyps than those eating fewer than 12 grams ... The other study, conducted on 520,000 people in 10 European countries and called the largest study ever, also initially found a 25% reduced rate in colorectal cancer in those eating high-fiber diets of about 35 grams daily compared with those eating less than 15 ... the protective effect was greatest on the left side of the colon, where most cancers originate ... Fiber is believed to help reduce risk in two ways: It keeps you regular to remove toxins from the intestines, and bacteria living in the gut feeds on it -- producing beneficial byproducts to keep the colon healthy"
• Europe-Wide Study Finds Fibre Can Cut Colorectal Cancer Risk By Up To 40% - Doctor's Guide, 5/1/03 - "People consuming an average of 35 g fibre a day can cut their risk of colorectal cancer up to 40%, compared to people who consume an average of 15 g per day ... Protection was greatest for the left side of the colon, and least for the rectum ... foods supplying fibre also contribute many other nutrients and phytochemicals that have been linked to cancer protection, and which could account for the protective effects seen"
• Latest Evidence Links High-Fibre Diet With Reduced Colon Cancer Risk - Doctor's Guide, 5/1/03
• Selenium Reduces Risk of Some Cancers: FDA Approves Claim - New Hope Natural Media, 4/17/03 - "Companies that manufacture selenium supplements will now be permitted by the United States Food and Drug Administration (FDA) to claim that selenium supplements may reduce the risk of some cancers, according to a statement by the FDA. Although the FDA does not permit manufacturers to list specific types of cancer in the health claim, studies suggest selenium supplementation may reduce the risk of colon, prostate, lung, liver and esophageal cancers" - See iHerb and Vitacost selenium products.
• Calcium, vitamin D, dairy products, and risk of colorectal cancer in the cancer prevention study II nutrition cohort - Cancer Causes Control 2003 Feb;14(1):1-12 - "Total calcium intake (from diet and supplements) was associated with marginally lower colorectal cancer risk in men and women ... The association was strongest for calcium from supplements ... Total vitamin D intake (from diet and multivitamins) was also inversely associated with risk of colorectal cancer, particularly among men"
• Red Meat + Fats + Pasta = Colon Cancer - WebMD, 2/10/03 - "Women who ate the most Western foods had 50% more colon cancers than the women who ate the least Western foods"
• Low Dietary Copper Increases Fecal Free Radical Production, Fecal Water Alkaline Phosphatase Activity and Cytotoxicity in Healthy Men - J. Nutr. 133:522-527, 2/03 - "One possible dietary factor that may increase susceptibility to colon cancer is inadequate copper intake ... Low dietary copper significantly (P < 0.01) increased fecal free radical production"
• Colon Cancer Rise Linked to Beef, Pork - WebMD, 11/15/02 - "a high intake of red meat -- including beef and pork -- doubled the risk of colorectal cancer. No rise was seen for those reporting increased consumption of other meats or seafood. Eating vegetables was associated with a reduction in risk ... People who ate lots of red meat and few vegetables were more than 2.5 times more likely to get colon cancer"
• More Good News on Tea - WebMD, 9/27/02 - "The latest studies suggest tea might lower cholesterol, improve heart health, prevent rectal cancer in women, and reduce cell damage in smokers" - See iHerb or Vitacost green tea products.
• Folic Acid Fights Colon Cancer - WebMD, 7/19/02
• Folic Acid Supplement Reduces Cell Proliferation In High Risk Colorectal Cancer Patients - Doctor's Guide, 7/18/02 - "Patients at high risk of colorectal cancer could cut their risk dramatically with a daily supplement of 2 mg of folic acid" - See iHerb or Vitacost folic acid products.
• Moderate Calorie Cutbacks Fight Cancer - WebMD, 4/24/02
• Aspirin Lowers Colon Cancer Risk - Intelihealth, 4/8/02 - "A daily baby aspirin modestly reduces the risk of colon cancer by preventing the growth of ominous polyps ... the 80-milligram baby aspirin size taken daily reduces this risk by 19 percent ... the researchers found that 38 percent of those getting baby aspirin had new polyps, compared with 47 percent of people getting placeboes. However, little benefit was seen among those getting full-size aspirin. Their recurrence rate was 45 percent"
• Baby Aspirin Lowers Colon Cancer Risk - WebMD, 4/8/02
• Exposure To Sunlight Lowers Risks Of Four Cancers - Doctor's Guide, 4/4/02 - "exposure to sunlight contributes to non-melanoma skin cancer. "By contrast, several ecological studies suggest that sunlight may protect against female breast, ovarian, prostate, and colon cancer, all diseases that contribute to a substantially higher proportion of cancer mortality in the western industrialized world." ... Some studies have suggested an association between circulating vitamin D in blood, which is largely derived from sunlight, or dietary vitamin D and colorectal, prostate and female breast cancers"
• Calcium Intake May Be Associated With Reduced Risk Of Colon Cancer - Intelihealth, 3/19/02 - "Men and women who included more than 700 to 800 mg of calcium in their diets each day had a 40% to 50% lower risk of distal colon cancer compared with participants taking less than 500 mg of calcium each day"
• Boning Up on Calcium Fights Colon Cancer - WebMD, 3/19/02
• Well-Rounded Prevention May Lower Colon Cancer Risk - WebMD, 2/4/02
• Almonds Promote Colon Health - Nutrition Science News, 6/01
• Well-Rounded Prevention May Lower Colon Cancer Risk - WebMD, 2/4/02 - "Research suggests that aspirin, nonsteroidal anti-inflammatory drugs, the vitamin folate, and the mineral calcium, all may have a protective effect against colon cancer. Estrogen, too, may have a protective effect ... The best way to lower your risk of colon cancer is to reduce red meat intake, exercise regularly, stop smoking, and control your weight ... aspirin reduced the risk of colon cancer death by 40%, when taken 16 times per month or more. Similarly, the nonsteroidal anti-inflammatory drug Clinoril (sulindac) significantly reduced polyps in high-risk people. Both aspirin and Clinoril can cause stomach bleeding, but the new nonsteroidal anti-inflammatory drug Celebrex may prevent colon polyps without this side effect ... The herb rosemary, the spice turmeric, the skin of red grapes, and green tea all have similar effects as the [nonsteroidal anti-inflammatory drug] Celebrex"
• Very Low Fruit, Vegetable Consumption Produces Highest Colorectal Cancer Risk - Doctor's Guide, 4/6/01 - "Sub-analysis showed that this association was due largely to fruit consumption ... We observed no association between colorectal cancer risk and the consumption of cereal fiber, even at amounts substantially greater than previously examined"
• Canceling Cancer: New Cancer Prevention Strategies on the Horizon - WebMD, 3/26/01 - "Huerta and his team used a compound similar to vitamin D but with some different properties. Sure enough, this compound, which they call Ro 26-9114, reduced the growth of colon tumors in mice to a similar degree as regular vitamin D but without the problematic side effects"
• Calcium Pills May Stave Off Colon Cancer - WebMD, 3/9/01 - "among patients who took calcium (for one year), the size and growth of the benign tumors -- as measured by pathologists who looked at tissue biopsies -- was reduced by 58%. In contrast, only a 26% reduction was seen in patients who did not take calcium . . . The protective effect of calcium was most pronounced among the patients on a low-fat diet and taking calcium: 73% of those patients had noticeable reductions in adenomas. In contrast, there were no differences in adenoma reductions between high-fat eaters in the calcium and no-calcium groups"
• Vitamin A Reduces Risk Of Colorectal Adenoma - Doctor's Guide, 2/23/01 - "Higher serum concentrations of vitamin A, however, were significantly associated with a reduced risk of colorectal adenomas"
• Colon Cancer Prevented, Promoted by Diet - Nutrition Science News, 2/01
• Wine May Reduce the Risk of Colon Cancer, Even in Smokers - WebMD, 10/16/00
• Study: Fiber Doesn't Prevent Cancer - Intelihealth, 10/13/00 - "29 percent of those receiving the supplement (ispaghula husk, a compound similar to psyllium that is not part of the average diet) got at least one new tumor within three years. That compares with 20 percent of those given fake granules"
• Fiber May Hurt, More Than Help, in Preventing Colon Cancer - WebMD, 10/12/00
• Chemicals in apples slow cancer growth in lab tests, scientists report - CNN, 8/30/00
• Low Fat, High Fiber Doesn't Cut Colon Cancer Risk - Nutrition Science News, 8/00
• Can calcium prevent colon cancer? - Nutrition Science News, 6/00
• Preventing Colon Cancer: What You Can Do - WebMD, 4/19/00
• Estrogen Reduces Risk Of Colorectal Cancer - Doctor's Guide, 10/28/99
• Calcium Supplements Help Prevent Polyp Recurrence - Doctor's Guide, 1/14/99
• Study says calcium may cut colon cancer risk - CNN, 9/22/98
• Vitamin E May Enhance Effectiveness Of Colorectal Cancer Drug - Doctor's Guide, 11/20/97
• Vitamin Supplements May Reduce Colon Cancer Risk - Doctor's Guide, 11/6/97
• Vitamin E May Help Protect Against Colon Cancer - Doctor's Guide, 11/5/97
• Scientific Evidence On FOS Deserves Serious Attention, Nutrition Expert Says - Doctor's Guide, 5/8/97
• Research Highlights Positive Effects of Dietary Supplement NutraFlora FOS - Doctor's Guide, 12/9/96

CME:

• Doctor's Guide colorectal cancer CME courses
• Medscape colon cancer CME courses
• Medical Management of Colorectal Cancer - Medscape, 2/28/05
• Surgical Management of Colorectal Cancer - Medscape, 2/28/05
• New Treatment Options for Colorectal Cancer - Medscape, 2/24/05

General Information:

• Colon Cancer - American Academy of Family Physicians
• Colon Cancer - emedicine.com
• Colon Cancer - familydoctor.org
• Colorectal Cancer - Intelihealth
• Colon Cancer - Veritas Medicine
• Books on colon cancer - Amazon.com
• Treatments for colon cancer - Medifocus.com

Other News:

• High blood sugar levels in older women linked to colorectal cancer - Science Daily, 11/29/11 - "The Einstein study involved women who were enrolled in the National Institutes of Health''''s landmark Women''''s Health Initiative study ... By the end of the 12-year period, 81 of the women had developed colorectal cancer. The researchers found that elevated baseline glucose levels were associated with increased colorectal cancer risk -- and that women in the highest third of baseline glucose levels were nearly twice as likely to have developed colorectal cancer as women in the lowest third of blood glucose levels ... obesity''''s impact on this cancer may be due to elevated glucose levels, or to some factor associated with elevated glucose levels"
• Reduced Risk of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes: A meta-analysis - Diabetes Care. 2011 Oct;34(10):2323-8 - "Both in vitro and in vivo studies indicate that metformin inhibits cancer cell growth and reduces cancer risk ... The analysis included five studies comprising 108,161 patients with type 2 diabetes. Metformin treatment was associated with a significantly lower risk of colorectal neoplasm (relative risk [RR] 0.63 [95% CI 0.50-0.79]; P < 0.001). After exclusion of one study that investigated colorectal adenoma, the remaining four studies comprised 107,961 diabetic patients and 589 incident colorectal cancer cases during follow-up. Metformin treatment was associated with a significantly lower risk of colorectal cancer (0.63 [0.47-0.84]; P = 0.002)" - See metformin at IAS.
• Alcohol Linked to Colorectal Cancer Risk - Medscape, 9/18/11 - "Overall, the dose-risk analysis found a statistically significant 7% increased risk for colorectal cancer for 10 g per day of alcohol intake, which includes light alcohol consumers. According to the researchers, 1 drink is equivalent to 12 g of ethanol" - Note:  My problem with alcohol is that it increases free radicals which has to increase signs of aging like wrinkling.  It does decrease heart disease but it also increases breast cancer, etc.
• High levels of 'good' cholesterol may cut bowel cancer risk - Science Daily, 3/7/11 - "Each rise of 16.6 mg/dl in HDL and of 32 mg/dl in apoA reduced the risk of bowel cancer by 22% and 18%, respectively, after taking account of diet, lifestyle, and weight ... low HDL levels have been linked to higher levels of proteins involved in inflammation, while higher levels of proteins that dampen down the inflammatory response have also been linked to high HDL levels ... The pro inflammatory proteins boost cell growth and proliferation while curbing cell death, so HDL may alter the inflammatory process in some way"
• Adiponectin and adiponectin receptor in relation to colorectal cancer progression - Int J Cancer. 2010 Dec 15;127(12):2758-67 - "Although obesity is a risk factor for colorectal cancer, the underlying mechanism is not clear. Adiponectin is an adipokine that binds to 2 types of receptors, AdipoR1 and AdipoR2. The plasma concentrations of adiponectin are reduced in obese individuals and adiponectin has been reported to have anticarcinogenic properties. Furthermore, AdipoR1 and AdipoR2 have been reported to be expressed in several malignancies ... AdipoR1 and AdipoR2 immunostaining was detected in 72 and 68% of human colorectal cancer tissue, respectively. AdipoR1 and AdipoR2 expression levels were inversely related to T stage. The lowest AdipoR1 and AdipoR2 expression were detected in poorly differentiated adenocarcinoma. RT-PCR also showed the expression of AdipoR1 and AdipoR2 in HCT116 and SW620. MTT assay and TUNEL assay demonstrated the tendency of growth inhibition and apoptosis induction in both cell lines after full-length adiponectin treatment although statistically insignificant. Microarray analysis revealed several gene responses to full-length adiponectin, including upregulation of ENDOGL1 and MT1G. In conclusion, AdipoR1 and AdipoR2 may be intimately related to the progression of colorectal cancer"
• Lack of sleep found to be a new risk factor for colon cancer - Science Daily, 2/8/11 - "individuals who averaged less than six hours of sleep at night had an almost 50 percent increase in the risk of colorectal adenomas compared with individuals sleeping at least seven hours per night. Adenomas are a precursor to cancer tumors, and left untreated, they can turn malignant"
• Anti-gout drug may decrease risk for colorectal adenoma progression - Science Daily, 11/8/10
• Telomere length affects colorectal cancer risk - Science Daily, 10/28/10 - "Patients with the longest telomeres -- those patients in the 95th percentile of telomere length -- were 30 percent more likely to develop colorectal cancer than those in the 50th percentile, the results showed. Overall, the individuals with the shortest and the longest telomere lengths were at an increased risk for colorectal cancer"
• Radiation before surgery keeps colorectal cancer from returning, study finds - Science Daily, 10/25/10
• Higher bone mineral density is associated with a decreased risk of colorectal adenomas - Int J Cancer. 2010 Oct 14 - "patients in the highest tertile of total body BMD (>1.294 g/cm(2)) and in the middle tertile (≥1.167 to ≤1.294 g/cm(2)) compared to those with a total body BMD in the lowest tertile (<1.167 g/cm(2)) had a lower risk of colorectal adenomas (highest vs. lowest tertile: OR=0.29 (0.10-0.84); middle vs. lowest tertile: OR=0.26 (0.08-0.80); p-trend=0.02)"
• Statin use associated with statistically significant reduction in colorectal cancer - Science Daily, 10/18/10 - "The relative risk was 0.88 (95% CI 0.84-0.93; n=22) and represents a 12% reduction in the odds of colorectal cancer among statin users ... the most common category of statins, lipophilic (which includes atorvastatin or Lipitor®), showed the greatest effect ... long-term use of statins is associated with reduced risk of several cancers, including breast, prostate, lung, pancreas and liver"
• New recommendations issued for use of cetuximab in colon cancer therapy - Science Daily, 7/16/10
• Bacteria as a predicter of colorectal cancer - Science Daily, 5/25/10 - "Several bacterial signatures were detected only in subjects with polyps, others only in subjects without polyps. Eubacterium ramulus was increased in the stools of subjects with polyps while Ruminococcus sp and a human intestine firmicute were increased in subjects without polyps. In tissue samples, Acidovorax sp. was found more frequently in subjects with polyps. Other bacterial signatures that differed between cases and controls were observed but did not match any know bacteria, suggesting unidentified and uncharacterized bacteria are also present"
• Minimally Invasive Surgery Shown Safe And Effective Treatment For Rectal Cancer - Science Daily, 11/10/09
• New Old Drug Fights Colon Cancer - Science Daily, 10/13/09
• Estrogen May Improve Colon Cancer Survival - WebMD, 9/29/09
• Visceral Obesity and Insulin Resistance as Risk Factors for Colorectal Adenoma: A Cross-Sectional, Case-Control Study - Am J Gastroenterol. 2009 Sep 15 - "insulin resistance was associated with the presence of colorectal adenoma"
• Evaluating More Lymph Nodes May Not Improve Identification Of Late-stage Colorectal Cancer - Science Daily, 8/26/09
• Alcohol And Smoking Are Key Causes For Bowel Cancer - Science Daily, 6/2/09 - "people who consume the largest quantities of alcohol (equivalent to > 7 drinks per week) have 60% greater risk of developing the cancer, compared with non-drinkers ... Smoking, obesity and diabetes were also associated with a 20% greater risk of developing bowel cancer - the same risk linked with consuming high intakes of red and processed meat"
• Inflammation In Colon May Get Doused Before Fueling Cancer Development - Science Daily, 2/10/09
• Using 2 newer drugs may worsen colon cancer - MSNBC, 2/4/09
• Inflammation Directly Linked To Colon Cancer; Potential New Drug Targets Revealed - Science Daily, 2/2/09
• Inflammation Contributes To Colon Cancer - Science Daily, 1/22/09
• Hormone Therapy Associated With Reduced Colorectal Cancer Risk - Science Daily, 1/8/09 - "The combination of estrogen plus progestin, which women stopped taking in droves following the news that it may increase their risk of breast cancer, may decrease their risk of colorectal cancer ... Any use of estrogen therapy was associated with a 17 percent reduced risk in colorectal cancer. Among those who used estrogen, the largest reductions were seen among those who were current users (25 percent reduced risk) and users of ten or more years duration (26 percent reduced risk)"
• Menopausal hormone therapy and risk of colorectal cancer - Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):196-203 - "evaluated colorectal cancer risk associated with the duration and recency of specific menopausal hormone therapy formulations (i.e., unopposed estrogen versus estrogen plus progestin) and regimens (i.e., sequential versus continuous estrogen plus progestin use) ... We observed a decreased risk of colorectal cancer among ever users of unopposed estrogen therapy (RR, 0.83; 95% CI, 0.70-0.99). Among estrogen users, the largest reduced risk was observed for current users (RR, 0.75; 95% CI, 0.54-1.05) and users of >/=ten years duration (RR, 0.74; 95% CI, 0.56-0.96). We found a reduced risk among users of estrogen plus progestin therapy (RR, 0.78; 95% CI, 0.60-1.02), with sequential regimen users (progestin <15 days per cycle) having the largest risk reduction (RR, 0.64; 95% CI, 0.43-0.95). Past users of >/=5 years ago (RR, 0.55; 95% CI, 0.32-0.98) had the largest risk reduction. In this study, estrogen plus progestin use, especially sequential regimen use, was associated with the largest overall reduction of colorectal cancer risk"
• Metabolic Syndrome Ups Colorectal Cancer Risk - Science Daily, 10/6/08 - "metabolic syndrome patients had a 75 percent higher risk of colorectal cancer compared to those without metabolic syndrome"
• Virtual Colonoscopy As Good As Other Colon Cancer Screening Methods, Study Finds - Science daily, 9/18/08
• New Results Help Predict Treatment Response In Colorectal Cancer - Science Daily, 9/17/08
• How Often To Screen For Colon Cancer? Study Finds 5-year Risk Extremely Low - Science Daily, 9/17/08
• New Colorectal Screening Procedure Is Accurate And Less Invasive, Trial Finds - Science Daily, 9/17/08
• Colorectal Cancer Screening Should Start At Age 50, Study Confirms - Science Daily, 9/2/08
• Gene Mutation May Increase Colorectal Cancer Risk - WebMD, 8/14/08
• Different Type Of Colon Cancer Vaccine Reduces Disease Spread, Scientists Show - Science Daily, 6/24/08
• Researchers See Alternative To Common Colorectal Cancer Drug - Science Daily, 6/17/08
• Novel Therapeutic Strategy For Colon Cancer Treatment - Science  Daily, 6/9/08
• Combination Targeted Therapies in Renal Cancer - Medscape, 6/9/08
• Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice - Int J Cancer. 2008 Jun 2 - "colitis-associated colon cancer (CAC) ... simvastatin could be a potential chemopreventive and therapeutic agent of CAC as well as de novo colon cancer"
• Drug Combo Stops Recurrent Colon Polyps - WebMD, 4/15/08 - "A combination of the targeted anticancer agent DFMO and the antiarthritis drug sulindac reduces the risk of recurrent colon polyps by up to 95%"
• Road Map To Safer Pain Control Proposed; Cost Savings During Colonoscopies - Science Daily, 3/11/08
• Flat Lesions Linked to Colon Cancer - WebMD, 3/6/08
• High-dose NSAIDs May Prevent Colon Cancer - oncologystat.com. 2/5/08 - "people who took more than 2325 mg of aspirin weekly reduced colon cancer risk by 21%, compared to people who took less aspirin. Men who took 7 to 14 aspirins a week had a 28% decreased risk, and those who took more than 14 aspirins weekly had a 70% decrease in their risk of developing the disease. The advantages were only seen after 5 years of use, and taking less than 1½ pills weekly did not reduce the risk of developing the disease. The effect was also seen with the use of other NSAIDs, such as ibuprofen and naproxen"
• Smoking Can Double Risk Of Colorectal Polyps - Science Daily, 2/1/08 - "Smokers have a two-fold increased risk of developing colorectal polyps"
• Strong Link Between Obesity And Colorectal Cancer - Science Daily, 12/14/07 - "obese individuals (Body Mass Index* (BMI) >30 kg/m2) have a 20% greater risk of developing colorectal cancer compared with those of normal weight (BMI < 25 kg/m2) ... carrying even a few excess kilos substantially increases the risk of colorectal cancer; for every 5 kg weight gain the risk of developing the cancer increases by 7%"
• Diabetes May Increase Woman's Risk of Colorectal Cancer - oncologystat.com, 12/7/07 - "There was about a 50% increased risk of colorectal cancer in women with diabetes ... The researchers hypothesized that the elevated levels of insulin typically seen in people with type 2 diabetes may play a central role. Insulin stimulates the growth of normal colonic and carcinoma cells"
• PET/CT Combination Can Highly Increase Detection Of Colorectal Cancer - Science Daily, 10/29/07
• Insulin Linked to Colonic Polyps, Neoplasia - oncologystat.com, 10/23/07 - "those with poorly controlled diabetes, identified by a high serum level of hemoglobin A 1c (HbA 1c ), were significantly more likely to have advanced colonic adenomatous polyps, compared with diabetic patients with better glycemic control ... patients with poorly controlled diabetes were more than sixfold as likely to have advanced polyps and nearly sixfold as likely to have right-sided polyps, compared with patients who had better glycemic control. The average number of polyps found in poorly controlled patients was 5.5; in better-controlled patients, the average was 2.5 polyps per patient. Results from a third study reported at the meeting showed that having three or more polyps was the strongest predictor of risk for recurrent advanced neoplasia in the colon"
• The Association of Elevated HbA1c on the Behavior of Adenomatous Polyps in Patients with Type-II Diabetes Mellitus - Dig Dis Sci. 2007 Oct 16 - "colonic adenomatous polyps (APs) ... univariate analysis (UA) ... UA demonstrated that patients with poorly controlled DM-2 had a significantly increased incidence of right-sided APs (P = 0.001), a greater number of APs (P < 0.005), more advanced APs (P < 0.005), a younger age of presentation (P = 0.001), a history of smoking (P = 0.05), and greater use of exogenous insulin (P = 0.01). Logistic regression, as measured by HbA1c, demonstrated that poorly controlled DM-2 independently predicted a greater prevalence of right-sided AP, a more advanced lesion at the time of presentation, a greater number of polyps, and greater use of exogenous insulin"
• Removing Colon Polyps Cuts Death Risk - WebMD, 10/15/07 - "The researchers analyzed data on 2,602 men and women in the National Polyp Study, the landmark trial that showed that an initial colonoscopy during which the colon is cleared of precancerous polyps with regular follow-up exams significantly cut the risk of developing colon cancer by up 90% and of dying from the cancer by up to 92%"
• Obesity Ups Women’s Colon Cancer Risk - WebMD, 10/15/07 - "Obesity more than doubles a woman’s risk of developing colon cancer or growths that can lead to colon cancer"
• Interleukin-8, Key Marker For Colorectal Cancer Treatment - Science Daily, 10/9/07
• Inside Job: New Radioactive Agents For Colon Cancer Work Inside Cells - Science Daily, 10/9/07
• Low-Dose Aspirin Plus Statins Protects Against Colorectal Cancer - Medscape, 10/4/07 - "Dr. Brenner's group observed a modest risk reduction of colorectal cancer among regular users of low-dose aspirin (adjusted odds ratio = 0.77). A stronger association was found with regular use of statins (OR 0.65). The strongest risk reduction was seen in subjects who used combination low-dose aspirin and statins (OR 0.63), especially if both drugs were used for at least 5 years (OR 0.38)"
• Studies endorse 'virtual colonoscopy' - USATODAY.com, 10/4/07
• Studies Lend Insights Into Colorectal Cancer Screening - Science Daily, 10/1/07
• SCOUT Regimen Useful as First-Line Treatment for Metastatic Colorectal Cancer - Doctor's Guide, 9/26/07
• Current Chemotherapy Regimens for Advanced Colorectal Cancer Prolong Survival - Doctor's Guide, 9/21/07
• ‘Western’ Diet Tied to Colon Cancer - WebMD, 8/14/07 - "Colon cancer recurrences or death were nearly 3.5 times more common among patients who most closely followed a Western diet than among patients who followed it the least"
• Statins May Cut Colon Cancer Recurrence - Medscape, 7/26/07 - "Just 6 of 89 patients (6.7%) treated with any statin relapsed, as opposed to 43 of 269 (16%) patients with no statin use"
• Flaws In Colonoscopies May Increase Risk Of Colon Cancer - Science Daily, 5/23/07
• Cetuximab Increases Survival In Advanced Colorectal Cancer Patients - Science Daily, 4/19/07
• Colon Polyp Return Likelier in Men - WebMD, 4/16/07
• Colon Cancer Survival Linked To Number Of Lymph Nodes Examined - Science Daily, 3/22/078/08
• Aspirin Or NSAIDs Won't Prevent Colorectal Cancer - Science Daily, 3/20/07
• New Combined Laparoscopy and Colonoscopy Procedure May Avoid Need for Major Surgery - Doctor's Guide, 3/7/07
• Avastin Slows Colon Cancer Growth - WebMD, 1/22/07
• Lymph Node Yield Similar With Laparoscopic or Open Colectomy - Doctor's Guide, 10/20/06
• Adding Cetuximab (Erbitux) to First-Line Chemotherapy Boosts Results in Metastatic Colorectal Cancer - Doctor's Guide, 10/4/06
• FDA Approves New Colon Cancer Drug - WebMD, 9/27/06
• Chemotherapy Does Not Improve Survival in Rectal Cancer - Medscape, 9/13/06
• Study Finds That Vioxx Reduces The Risk Of Colorectal Polyps - Science Daily, 8/31/06
• FDA Approves Avastin (Bevacizumab) in Combination With Chemotherapy for Second-Line Metastatic Colorectal Cancer Patients - Doctor's Guide, 6/21/06
• Trial Demonstrates Safety of Oxaliplatin/5-FU Combination in Treating Colorectal Cancer - Doctor's Guide, 6/9/06
• Adding Cetuximab to Two Chemotherapy Regimens for Metastatic Colorectal Cancer Appears to Enhance Overall Response and Survival - Doctor's Guide, 6/6/06
• Continuous Chemotherapy No More Helpful Than Retreatment in Metastatic Colorectal Cancer - Doctor's Guide, 6/6/06
• Virtual Colonography and Optical Colonoscopy Yield Similar Screening Accuracy - Doctor's Guide, 5/24/06
• Is Colonoscopy After Age 80 Worth It? - WebMD, 5/23/06
• Women With Type 2 Diabetes at Increased Risk of Colorectal Adenomas - Doctor's Guide, 5/23/06 - "type 2 diabetics had up to a 2- to 3-fold increased risk of having any adenoma or advanced adenomas, which are precancerous polyps"
• Almost 1/3 of Colon Cancer Patients Stop Chemotherapy, Leading to Double The Death Rate - Doctor's Guide, 4/28/06
• New Drug Combination May Enhance Effectiveness of Colorectal Cancer Treatments - Doctor's Guide, 4/11/06
• Smokers, Drinkers and Men Appear to Develop Colorectal Cancer at Earlier Ages - Doctor's Guide, 3/30/06
• Antidepressants May Cut Colon Cancer - WebMD, 3/27/06
• Combination of Pemetrexed and Oxaliplatin Shows Activity in Metastatic Colorectal Cancer Patients - Doctor's Guide, 1/31/06
• Phase 2 Trial of Avastin (Bevacizumab) and FOLFIRI Produce Clinical Benefit in Most Metastatic Colorectal Cancer Patients - Doctor's Guide, 1/30/06
• Addition of Oxaliplatin to FOLFIRI Regimen Increases Survival of Patients With Metastatic Colon Cancer - Doctor's Guide, 1/30/06
• Use of Chemotherapy after Surgery for Colon Cancer Has Risen - Doctor's Guide, 12/7/05
• Many colon cancer patients under-treated - MSNBC, 12/7/05
• Molecular Advances Driving New Approaches in Colorectal Cancer Treatment - Doctor's Guide, 11/18/05
• Treatment Advances in Colorectal Cancer Often Accompanied by Toxicity Management Challenges - Doctor's Guide, 11/17/05
• New Treatment Combinations Expanding Options for Patients with Early-Stage Colorectal Cancer - Doctor's Guide, 11/17/05
• Diabetics Face Increased Risk of Colorectal Cancer - Doctor's Guide, 11/2/05 - "hyperinsulinemia and hyperglycemia promote the growth of colorectal cancer"
• Xeloda plus Oxaliplatin (Xelox) Dramatically Reduces Hospital Visits by Over 60% - Doctor's Guide, 11/2/05
• Combination Therapy with Irinotecan (CPT-11) and Pyrimidine S-1 for Inoperable Recurrent Advanced Colorectal Cancer UEGW - Doctor's Guide, 10/21/05
• Chemotherapy Plus Radiation Better in Preventing Local Recurrence of Rectal Cancer - Doctor's Guide, 10/21/05
• Dual-Drug Therapy Targets One Colon Cancer Gene - Doctor's Guide, 8/16/05
• FDA Grants Fast Track Designation for Panitumumab for Treatment of Metastatic Colorectal Cancer - Doctor's Guide, 8/1/05
• Flexible Sigmoidoscopy in Early Detection of Colorectal Cancer - Doctor's Guide, 7/7/05
• Landmark Study Shows Oral Xeloda Could Replace Standard Intravenous 5-Fu/Lv Chemotherapy - Doctor's Guide, 6/30/05
• Type 2 diabetes mellitus and the risk of colorectal cancer - Clin Gastroenterol Hepatol. 2005 Jun;3(6):587-94 - "Type 2 diabetes mellitus is associated with an increased risk of colorectal cancer"
• Revolutionary Treatment Avastin (Bevacizumab) Helps People With Advanced Colorectal Cancer Live Longer While Preserving Quality of Life - Doctor's Guide, 6/17/05
• Bevacizumab for Colorectal and Other Cancers - Medscape, 6/15/05
• FDA Approves Oral Xeloda (Capecitabine) for Adjuvant Treatment of Colon Cancer - Doctor's Guide, 6/15/05
• Chemotherapy Options Improve For Patients With Advanced Colorectal Cancer - Science Daily, 6/9/05
• Oral-Based Regimen Safe, Effective for Metastatic Colorectal Cancer - Doctor's Guide, 6/6/05
• Cholesterol Drugs May Prevent Colon Cancer - WebMD, 5/25/05 [Abstract] - "people who took cholesterol-lowering statin drugs for five years cut their colon cancer risk in half"
• Multi-National Trial Demonstrates Efficacy of Capecitabine (Xeloda) Compared With 5-Fluorouracil and Leucovorin - Doctor's Guide, 5/23/05
• Afternoon Colonoscopies Show Significantly Higher Failure Rates Than Morning Procedures - Doctor's Guide, 5/20/05
• What Colon Cancer Test Is Best for Women? - WebMD, 5/18/05
• Reduced-Dose Capecitabine Effective as First-Line Therapy in Older, Less Fit Patients With Advanced Colorectal Cancer - Doctor's Guide, 5/17/05
• Oxaliplatin Reduces Recurrence in Early-Stage Colorectal Cancer - Doctor's Guide, 5/17/05
• Wireless Capsule Endoscopy Finds More Small Bowel Polyps Than Barium Contrast Series - Doctor's Guide, 5/16/05
• 'Keyhole' Surgery Effective for Colon Cancer - WebMD, 5/12/05
• 'Virtual Colonoscopy' Effective In Finding Most Polyps But May Miss Small Ones - Science Daily, 4/23/05
• Transanal Endoscopic Microsurgery Effective on Early Rectal Cancer - Doctor's Guide, 3/7/05
• New Approach for Determining Who Should Receive Bowel Resectioning - Doctor's Guide, 3/7/05
• In Colorectal Liver Metastases, Complete Clinical Response Still Requires Surgery - Doctor's Guide, 3/7/05
• Concurrent Capecitabine With Preoperative Radiotherapy in Rectal Cancer - Doctor's Guide, 2/4/05
• Simplified Regimen May Have Higher Efficacy Than Standard Regimen for Advanced Colorectal Cancer - Doctor's Guide, 1/31/05
• 4-Year Data Show FOLFOX Maintains Disease-Free Survival Benefit for Adjuvant Colorectal Cancer Patients - Doctor's Guide, 1/31/05
• Radiation Therapy Plus Irinotecan, 5-Fluorouracil and Folinic Acid Feasible, Effective in Advanced Rectal Cancer - Doctor's Guide, 1/31/05
• Anemia Occurs Frequently in Colerectal Cancer Patients on FOLFOX Regimens - Doctor's Guide, 1/31/05
• First-Line Fluoroxuridine-Based Therapy Appears Active for Advanced Colorectal Cancer - Doctor's Guide, 1/31/05
• High-Dose Bevacizumab Plus Chemotherapy Shows Survival Benefit as Second-Line Treatment for Colorectal Cancer - Doctor's Guide, 1/28/05
• 4-Year Data Show FOLFOX Maintains Disease-Free Survival Benefit for Adjuvant Colorectal Cancer Patients - Doctor's Guide, 1/28/05
• Anaemia as a symptom of right colon cancer - Tech Coloproctol. 2004 Nov;8 Suppl 1:s62-4 - "Iron deficiency anaemia is a common symptom of right colon cancer"
• Colonoscopy Still Most Effective Colorectal Cancer Screening Method - Doctor's Guide, 1/20/05
• Colon Cancer Screening Test Called Inaccurate - WebMD, 1/18/05
• Red-Meat Eaters Risk Colon Cancer - WebMD, 1/11/05 - "Those who eat the most red meat -- beef and/or pork and/or processed meat products -- get colon cancer 30% to 40% more often than those who eat these foods only once in a while"
• Colorectal Cancer Screening Underutilized - Doctor's Guide, 1/10/05
• New Computer-Aided Detection System Detects Colon Polyps in Colons Previously Obscured by Contrast-Enhanced Fluid - Doctor's Guide, 1/5/05
• The Role of Targeted Therapies in Colorectal Cancer: An Expert Interview With Axel Grothey, MD - Medscape, 12/23/04
• Colonoscopy Best at Detecting Colon Cancer - WebMD, 12/16/04
• Bevacizumab Plus Oxaliplatin-Based Chemotherapy Prolongs Survival For Previously Treated Patients With Advanced Colorectal Cancer - Doctor's Guide, 11/29/04
• Gefitinib (Iressa) Active against Advanced Colorectal Cancer - Doctor's Guide, 11/18/04
• Xeloda (Capecitabine) Appears To Reduce Risk Of Colon Cancer Recurrence, Lessen Side Effects At Lower Cost Than Current Standard Treatment - Doctor's Guide, 11/15/04
• Bevacizumab Improves Survival Among All Colorectal Cancer Subgroups - Doctor's Guide, 11/15/04
• Panitumumab Plus Irinotecan, Fluorouracil, and Leucovorin Active as First-Line Treatment in Metastatic Colorectal Cancer - Doctor's Guide, 11/12/04
• Panitumumab Monotherapy Safe, Effective in Metastatic Colorectal Cancer - Doctor's Guide, 11/12/04
• Bevacizumab-Oxaliplatin Combination Safe in Second-Line Colorectal Cancer Treatment - Doctor's Guide, 11/12/04
• Gefitinib (Iressa) Active against Advanced Colorectal Cancer - Doctor's Guide, 11/12/04
• Oral Capecitabine Improves Disease-Free Survival as Adjuvant Colon Cancer Therapy - Doctor's Guide, 11/12/04
• Eloxatin (Oxaliplatin) Receives FDA Approval for the Treatment of Colon Cancer Following Surgery (Adjuvant Treatment) - Doctor's Guide, 11/5/04
• Staged Combination Treatment a Gentler Option for Advanced Colorectal Cancer Patients - Doctor's Guide, 11/4/04
• Ibandronate Reduces Bone Complications in Colorectal Cancer Patients With Bone Metastases - Doctor's Guide, 11/1/04
• Gout Drug Prevents Colon Cancer - WebMD, 10/18/04 - "Zyloprim reduced risk of colon cancer by two-thirds"
• Insulin May Increase Colon Cancer Risk - WebMD, 10/1/04 - "people with diabetes who had been taking insulin for three to five years had almost a threefold increase in colorectal cancer risk compared with those who did not take insulin ... The risk was even higher in people who took insulin for more than five years"
• Confocal Laser Colonoscopy May Accurately Diagnose Colorectal Cancer - Medscape, 9/29/04
• Colonoscopy Remains Most Sensitive, Best Test for Colorectal Cancer Screening - Doctor's Guide, 9/7/04
• Colonoscopy Doesn't Find All Polyps - WebMD, 9/6/04
• Virtual Colonoscopy Showing Promise as Colorectal Cancer Screening Option - Doctor's Guide, 9/1/04
• Study Shows Colonoscopy Misses 4% of Cancers - WebMD, 8/30/04
• New Colon Cancer Guideline On Chemotherapy For Stage II Colon Cancer - Doctor's Guide, 8/17/04
• Are Physicians Over-Performing Colonoscopy? - Doctor's Guide, 8/17/04
• Too Many Repeat Colonoscopies Performed - WebMD, 8/16/04
• ASCO Releases New Guideline on Chemotherapy for Stage II Colon Cancer - Doctor's Guide, 8/16/04
• Colon Cancer:  Prevention and Early Detection - Physician's Weekly, 8/9/04
• Adjuvant Chemotherapy For Colon Cancer Offers No Survival Benefit After 10 Years - Science Daily, 8/9/04
• Anastomotic Leak After Colorectal Cancer Surgery Linked to Lower Survival - Medscape, 8/6/04
• Erbitux (Cetuximab) Appears to Slow Disease Progression in Metastatic Colorectal Cancer - Doctor's Guide, 7/22/04
• Cetuximab Helpful in Irinotecan-Resistant Colon Cancer - Medscape, 7/21/04
• Current Issues in Systemic Treatment of Advanced Colorectal Carcinoma - Doctor's Guide, 7/9/04
• Bevacizumab Plus Fluorouracil-Based Chemotherapy is a New Option for Patients With Metastatic Colorectal Cancer - Doctor's Guide, 6/18/04
• Oxaliplatin Plus Fluorouracil and Leucovorin Improves Standard Adjuvant Therapy in Patients With Colon Cancer - Doctor's Guide, 6/17/04
• Oral Capecitabine (Xeloda) as Effective as Bolus 5-Fluorouracil/Leucovorin for Adjuvant Treatment of Colon Cancer - Doctor's Guide, 6/10/04
• Oral Uracil/Tegafur as Effective as Bolus 5-fluorouracil for Adjuvant Treatment of Stage II or III Colon Cancer - Doctor's Guide, 6/10/04
• Bleeding Negligible in Colorectal Cancer Patients on Anti-Coagulation and Bevacizumab Therapy - Doctor's Guide, 6/9/04
• Statin Use Appears to Reduce Risk of Colorectal Cancer - Doctor's Guide, 6/7/04
• Statin Drugs May Cut Colon Cancer Risk - WebMD, 6/7/04 - "When they added in those factors, "use of statins was still associated with a 46% reduction in risk.""
• FOLFOX4 (Oxaliplatin, Leucovorin, and Fluorouracil) Regimen Benefits Patients With Stage II Colon Cancer - Doctor's Guide, 6/6/04
• Presurgical Radiation and Chemotherapy Increased Complete Response Rate in Rectal Cancer - Doctor's Guide, 6/6/04
• Disease-Free Survival Rates Improve With the Addition of Oxaliplatin to Adjuvant Fluorouracil Plus Leucovorin for Resected Colon Cancer - Doctor's Guide, 6/3/04
• Drug That Cuts Off Tumor's Blood Supply Extends Lives Of Colorectal Cancer Patients - Science Daily, 6/3/04
• Fluorouracil-Based Chemotherapy Plus Bevacizumab Increased Survival Rates for Patients with Metastatic Colorectal Cancer - Doctor's Guide, 6/2/04
• Longer Survival With Colorectal Cancer Drugs - WebMD, 6/2/04
• Easier, Safer Colon Cancer Test? - WebMD, 5/19/04
• New Colon Cancer Test? - Dr. Weil, 5/18/04
• Recurrence Rates Similar After Laparoscopic or Open Colectomy for Colon Cancer - Doctor's Guide, 5/14/04
• Study Compares Colon Cancer Surgeries - Intelihealth, 5/13/04
• Looking Good: Colon Cancer Keyhole Surgery - WebMD, 5/12/04
• Computer-Aided Detection Acts as "Intelligent Colleague" in Detecting Polyps in the Colon - Doctor's Guide, 5/6/04
• Irinotecan/Raltitrexed Combination May be Effective Treatment for Advanced Colorectal Cancer - Doctor's Guide, 4/27/04
• Computed Tomographic Colonography Less Sensitive, Less Specific in Lesion Detection than Conventional Colonoscopy - Doctor's Guide, 4/13/04
• Virtual Colonoscopy Not Ready for Use Yet - WebMD, 4/13/04
• Laparoscopy, Conventional Resection Result in Similar Disease Control and Survival in Patients with Rectosigmoid Carcinoma - Doctor's Guide, 4/12/04
• Circadian-Timed Infusion of 5-Fluorouracil Plus Mitomycin-C No More Effective Than Protracted Venous Infusion, May Be More Toxic - Doctor's Guide, 4/8/04
• Laparoscopic Surgery Works for Colon Cancer - WebMD, 4/8/04
• Pre-Diabetes Increases Colon Cancer Risk - WebMD, 4/6/04
• New Guidelines Outline Metastatic Colon Cancer Treatment Choices - Doctor's Guide, 3/18/04
• New Drugs Incorporated Into Colon Cancer Guidelines - Doctor's Guide, 3/15/04
• Colon Cancer Screening - Physician's Weekly, 3/15/04
• Erbitux (Cetuximab) Receives FDA Approval to Treat Irinotecan Refractory Or Intolerant Metastatic Colorectal Cancer - Doctor's Guide, 2/13/04
• Oxaliplatin/Capecitabine Combination Effective First- and Second-Line Therapy in Metastatic Colorectal Cancer - Doctor's Guide, 2/12/04
• Combination of Oxaliplatin, 5-fluoruracil, and Folinic Acid Boosts Response Rate in Advanced Colorectal Cancer - Doctor's Guide, 2/12/04
• Colorectal Cancer Patients Treated By Fluorouracil-Leucovorin May Be At High Risk For Venous Thromboembolism - Doctor's Guide, 2/11/04
• Preoperative Radiation Combined With Oxaliplatin and Capecitabine Effective and Well Tolerated for Advanced Colorectal Cancer - Doctor's Guide, 2/11/04
• Oxaliplatin/Capecitabine Regimen Appears Effective, Tolerable for Advanced Colorectal Carcinoma Patients - Doctor's Guide, 2/10/04
• High-Glycemic Foods Linked to Colon Cancer - WebMD, 2/3/04 - "the future risk of colorectal cancers is nearly three times higher in women who eat the most high glycemic-load foods compared with those who eat lesser amounts"
• Link Found Between High C-Reactive Protein Levels and Subsequent Colon Cancer Development - Doctor's Guide, 2/3/04 - "Elevated plasma concentrations of C-reactive protein (CRP) appear to increase the risk of developing colon cancer"
• Elderly or Compromised Patients Do Better with Capecitabine in Advanced Colorectal Cancer - Doctor's Guide, 1/26/04
• Positron Emission Tomography Steers Surgeons Away From Unnecessary Colorectal Cancer Surgery - Doctor's Guide, 1/26/04
• Infused 5-Fluorouracil May Prove Superior to Bolus for Colorectal Cancer - Doctor's Guide, 1/26/04
• Higher Dose of Bevacizumab Safe and Effective as Addition to Colorectal Cancer Chemotherapy - Doctor's Guide, 1/26/04
• Bevacizumab May Safely and Effectively Combine With Chemotherapy for Colorectal Cancer - Doctor's Guide, 1/26/04
• Addition of Oxaliplatin To Bolus Schedule Of Fluroruracil Plus Folinic Acid Appears Safe, Effective In Treatment Of Metastatic Colorectal Cancer - Doctor's Guide, 1/22/04
• FDA Approves Eloxatin (Oxaliplatin) for Treatment of Advanced Colorectal Cancer - Doctor's Guide, 1/12/04
• Chemotherapy Regimen Including Irinotecan Followed By Oxaliplatin May Offer Improved Survival For Colorectal Cancer Patients - Doctor's Guide, 12/29/03
• Capecitabine Shows Improved Safety Over 5-fluorouracil-based Adjuvant Treatment for Colon Cancer - Doctor's Guide, 12/4/03
• 3-D Colonoscopy Produces Results Equivalent to Those of Conventional Procedure - Medscape, 12/2/03
• Virtual Colonoscopy at Least Equal in Efficacy to Conventional - Doctor's Guide, 12/2/03
• Virtual Colonoscopy Shows Promise - WebMD, 12/1/03
• Additional Study With Avastin in Metastatic Colorectal Cancer Shows Significant Increase in Progression-free Survival - Doctor's Guide, 11/27/03
• EKB-569 Combined With Capecitabine Safe in Advanced Colorectal Cancer - Doctor's Guide, 11/20/03
• Combination of Gefitinib and FOLFOX-4 Shows Promise in Metastatic Colorectal Cancer - Doctor's Guide, 11/20/03
• Preoperative Concurrent Chemotherapy and Radiation Improves Local Control of Rectal Cancer - Doctor's Guide, 10/31/03
• Virtual Colonoscopy Not Ready for Prime Time - Doctor's Guide, 10/22/03
• Heavy Alcohol Use Linked to Colon Cancer - Doctor's Guide, 10/22/03 - "Individuals who drink nine or more drinks made with distilled spirits a week for 10 years or more are about three times more likely to develop significant left-sided colorectal pathology than teetotalers"
• Spirits Raise Colon Cancer Risk - WebMD, 10/14/03
• Capecitabine Effective With Either Irinotecan or Oxaliplatin for Advanced Colorectal Cancer - Doctor's Guide, 10/2/03
• Adjuvant Chemotherapy Beneficial For Selected Patients With Colorectal Cancer - Doctor's Guide, 10/2/03
• Capecitabine/Oxaliplatin Combination is Tolerable First-Line Treatment for Advanced Colorectal Cancer - Doctor's Guide, 10/2/03
• Gemcitabine/5-Fluorouracil Does Not Appear To Be More Effective In One Metastatic Renal Cancer Subgroup Over Another - Doctor's Guide, 10/1/03
• Oral Capecitabine Plus Irinotecan Lowers Burden on Healthcare Workers and Patients with Advanced Metastatic Colorectal Cancer - Doctor's Guide, 9/22/03
• FDA Grants Priority Review to Eloxatin (Oxaliplatin) for First-Line Treatment of Metastatic Colorectal Cancer - Doctor's Guide, 9/17/03
• Comparable Detection Rates Between Multidetector-Array Computed-Tomographic Colonography And Colonoscopy - Doctor's Guide, 9/5/03
• Chemotherapy and Radiation Therapy Before Surgery Leads to Improved Sphincter Control for Rectal Cancer Patients - Doctor's Guide, 9/4/03
• The Humanised Monoclonal Antibody, Bevacizumab, Prolongs Time to Progression in Patients with Metastatic Renal-Cell Carcinoma - Doctor's Guide, 8/1/03
• Fluorouracil-Based Chemotherapy May Not Benefit Colon Cancer Showing High-Frequency Microsatellite Instability - Doctor's Guide, 7/29/03
• Bevacizumab (Avastin) Demonstrates Trend Toward Survival In Metastatic Colorectal Cancer - Doctor's Guide, 7/15/03
• Colorectal Cancer: Questioning the Digital Exam - Physician's Weekly, 7/14/03
• Percutaneous Radiofrequency Ablation Decreases Number Of Resections Needed For Liver Metastases - Doctor's Guide, 7/11/03
• Oral Antibiotic Prophylaxis Unnecessary Before Colorectal Surgery - Medscape, 6/25/03
• All Colorectal Polyps Should Be Treated - Medscape, 6/25/03
• Chemo-Radiation Before Surgery Offers Hope To Patients With Rectal Cancer - Doctor's Guide, 6/20/03
• Carbs, Sugar Don't Raise Colon Cancer Risk - WebMD, 6/17/03
• Irinotecan Addition to Chemotherapy Improves Colorectal Cancer Progression-Free Survival - Doctor's Guide, 6/17/03
• FOLFOX4 Shows Efficacy in Second-Line Treatment of Metastatic Colorectal Cancer - Doctor's Guide, 6/16/03
• Cetuximab/Irinotecan Combination Slows Progression of Colon Cancer - Doctor's Guide, 6/3/03
• DNA Test Might Predict Toxicity of Irinotecan - Doctor's Guide, 6/2/03
• Irinotecan Addition To Chemotherapy Improves Colorectal Cancer Survival - Doctor's Guide, 6/2/03
• Oxaliplatin Plus 5-Fluorouracil and Leucovorin Combination Effective in Second-Line Metastatic Colorectal Cancer Treatment - Doctor's Guide, 6/2/03
• Adjuvant Therapy with Oxaliplatin Increases Disease-Free Colorectal Cancer Survival - Doctor's Guide, 6/2/03
• Colonoscopy Patients Prefer Liquid Sodium Phosphate to Tablets - Doctor's Guide, 5/20/03
• Computed Tomography Colonography Reduces Radiation Risk In Colon Cancer Screening - Doctor's Guide, 5/7/03
• Alternative Method For Colon Cancer Screening More Comfortable For Patients - Doctor's Guide, 5/7/03
• Colonoscopy More Cost-Effective Against Colon Cancer Than Promising Cox II Drugs, Study Predicts - Doctor's Guide, 5/7/03
• Capsule with Microscopic Camera Provides Better Look at Small Bowel - Doctor's Guide, 5/6/03
• Sigmoidoscopy: How Often Is Enough? - WebMD, 4/15/03
• Radiotherapy Plus Oxaliplatin/Fluorouracil Effective For Preoperative Rectal Cancer - Doctor's Guide, 3/27/03
• Carbon Dioxide Causes Less Pain Than Air In Insufflation For Colonoscopy - Doctor's Guide, 3/24/03
• Newer Drugs Added to Colorectal Cancer Guidelines - Doctor's Guide, 3/14/03
• Colon Cancer Screening Rates Still Too Low - WebMD, 3/13/03
• Colon Cancer Subset: 5-FU Combo Better With Leucovorin Than Levamisole - Doctor's Guide, 2/28/03
• Colon Polyp Recurrence High - WebMD, 2/24/03
• Three Methods of Colon Cleansing Equally Effective in Colonoscopy Patients - Doctor's Guide, 2/17/03
• Which Colon Screening Method is Safest? - WebMD, 2/4/03
• Colorectal Cancer Screening Revisited - WebMD, 2/3/03
• New Guidelines for Colorectal Cancer Screening - Medscape, 2/3/03
• Recurrent And New Symptoms Are Common After Surgery For Rectal Cancer - Doctor's Guide, 1/16/03
• New Drug (Avastin) Improves Colon Cancer Survival - WebMD, 1/3/03 - See my Avastin page.
• Pill-Sized Camera Detects Bowel Abnormalities Missed By Other Diagnostic Tools - Doctor's Guide, 12/4/02
• Colon Cancer Test -- Once May Be Enough - WebMD, 12/3/02
• Thalidomide Shows Promise in Treatment of Renal Cell Carcinoma - Doctor's Guide, 11/15/02
• Ranitidine Proves Independently Beneficial For Selected Patients Following Resection Of Colorectal Tumours - Doctor's Guide, 11/5/02
• New Cancer Vaccine Starves Tumors - WebMD, 11/5/02 - "Mice that were given the vaccine showed slowed blood vessel growth and were able to fend off tumors when injected with three different types of cancer cells (melanoma, colon, and lung)"
• Bile Acid May Reduce Polyp Recurrence in Resected Colon Cancer Patients - Doctor's Guide, 10/24/02
• Test for Abnormal DNA May Help Monitor Colon Cancer Patients - Doctor's Guide, 10/24/02
• Oxaliplatin in Combination with 5-Fluorouracil and Leucovorin Offers New Hope for Metastatic Colorectal Cancer Patients Who Fail First Line Treatment - Doctor's Guide, 10/23/02
• Smoking an Important Risk Factor for Colorectal Polyps - Medscape, 10/22/02
• Oxaliplatin Helpful in Metastatic Colon Cancer - Medscape, 10/23/02
• Anti-inflammatory Drugs May Require Two Years' Treatment to Prevent Colorectal Cancer - Doctor's Guide, 10/22/02 - "Taking aspirin or an NSAID for at least two years reduced the risk of colorectal cancer by 32 percent"
• Colorectal Cancer Follow-up Cuts Death Risk by Nearly One-Half - Doctor's Guide, 10/22/02
• Polyps Burden in Women Similar in the 50s and 60s - Doctor's Guide, 10/22/02
• Abnormal Lesions Seen in 25 Percent of Patients Assigned to Colonoscopy - Doctor's Guide, 10/22/02
• ImClone Resumes Erbitux Tests - Intelihealth, 10/5/02
• Brachytherapy for Rectal Cancer a Good Alternative when Radical Surgery is Not Possible - Doctor's Guide, 9/20/02
• Short-Term Preoperative Radiotherapy Plus Total Mesorectal Excision an Option for Advanced Resectable Rectal Cancer - Doctor's Guide, 9/18/02
• Oral Tegafur May Be Good Alternative to 5-Fluorouracil in Preoperative Rectal Cancer Treatment - Doctor's Guide, 9/18/02
• Radiation Therapy Alone Can Treat Rectal Cancer - Doctor's Guide, 8/27/02
• Colon-Cancer Test Supposedly Easier - Intelihealth, 8/21/02
• Pre-op Radiotherapy Alternative to Lymphadenectomy for Rectal Cancer - Doctor's Guide, 8/13/02
• ELOXATIN, Chemotherapy for Advanced Colorectal Cancer, Receives Approval from the U.S. Food and Drug Administration - Doctor's Guide, 8/12/02
• Colorectal Tumour Regression Measured by Magnetic Resonance Imaging - Doctor's Guide, 7/25/02
• Premenopausal Obesity Doubles Colorectal Cancer Risk - Doctor's Guide, 7/18/02
• Laparoscopy May Be Better Than Open Colectomy for Colon Cancer - Medscape, 6/28/02
• Aspirin Can Be Safely Used Before and After Colonoscopy - Doctor's Guide, 6/10/02
• Stanford Researcher Advocates Aggressive, Preventive Anal Cancer Treatment - Doctor's Guide, 6/10/02
• New Study by Ochsner Clinic Foundation Determines How Frequently High-Risk Patients Should be Screened for Colorectal Cancer - Doctor's Guide, 6/7/02
• Neoadjuvant Therapy Recommended for All Cancers with Preoperative T3 Staging - Doctor's Guide, 6/6/02
• Tumor Margin "Budding" Predicts Recurrence and Should Influence Adjuvant Therapy Decision - Doctor's Guide, 6/6/02
• Is Transanal Excision Adequate for T1 Rectal Cancer? - Doctor's Guide, 6/6/02
• Routine Colonoscopy Screening For Colorectal Cancer Not Needed In Asymptomatic People In 40s - Doctor's Guide, 6/6/02
• Easier Colorectal Cancer Screening Option - WebMD, 5/30/02 - "British researchers have developed a new fecal test that detects cancerous cells in stool samples"
• New Stool Test Developed For Colorectal Cancer - Doctor's Guide, 5/30/02
• "Smart Tablet" Xeloda (Capecitabine) Is Highly Effective And Makes Chemotherapy Easier For Patients - Doctor's Guide, 5/24/02
• Physicians Often Skimp on Family Histories for Colorectal Cancers - Doctor's Guide, 5/23/02
• New Occult Blood Tests Highly Specific but Have Low Sensitivity - Doctor's Guide, 5/23/02
• Colorectal Cancer Rate Fails to Justify Frequent Screens - Doctor's Guide, 5/21/02
• New Colon Cancer Tests Planned - Intelihealth, 5/13/02
• Single Flexible Sigmoidoscopy Mass Screen A Success - Doctor's Guide, 4/12/02
• Intensive Follow-up Improves Colorectal Cancer Survival - Doctor's Guide, 4/10/02
• Low Dose Aspirin Associated With Reduced Risk For Recurrent Adenomas - Doctor's Guide, 4/8/02
• Positron Emission Tomography Scans Reduce Unnecessary Colorectal Surgeries - Doctor's Guide, 4/5/02
• Anti-Inflammatory [sulindac] Fails To Head Off Hereditary Colon Cancer - Doctor's Guide, 4/4/02
• Total Mesorectal Excision Using Laparoscopy Allows for More Precise Dissection in Rectal Cancer - Doctor's Guide, 3/18/02
• In Rectal Cancer, Laparoscopic Resection Does Not Raise Risk of Local Recurrence - Doctor's Guide, 3/15/02
• Encouraging Preliminary Results Seen for I-131 in Advanced Colorectal Cancer - Doctor's Guide, 2/28/02
• Doctors May Miss Second Colon Cancer - WebMD, 2/19/02
• Second Colorectal Cancers Often Develop Despite Follow-Up Tests - Intelihealth, 2/19/02
• Video pill makes 'fantastic voyage' inside body - CNN, 2/7/02
• New Colon Cancer Test Shows Promise - WebMD, 1/30/02
• Test May Help Halt Colon Cancer Early - Intelihealth, 1/18/02
• Laparoscopic-Assisted Colectomy Rejected For Colon Cancer - Doctor's Guide, 1/16/02
• New Procedure Holds Promise For The Wary - And For Earlier Detection - Intelihealth, 1/8/02
• Anti-colorectal cancer drug faces FDA obstacle - USA Today, 1/3/02
• Phosphate Tablets Better for Pre-Colonoscopy Colon Cleansing - Doctor's Guide, 12/13/01
• Colon Cancer Test Points To Most Effective Treatments - Doctor's Guide, 11/30/01
• U.S. Researchers Find Lag In Colon Cancer Testing - Intelihealth, 11/21/01
• Raltitrexed/Oxaliplatin Effective For Refractive Advanced or Metastatic Colorectal Cancer - Doctor's Guide, 10/25/01
• Intrahepatic Route no Better than Intravenous for 5-Fluorouracil/Leucovorin in Metastatic Colorectal Cancer - Doctor's Guide, 10/25/01
• Oral Xeloda (Capecitabine) Plus Intravenous Oxaliplatin Shows Good Efficacy and Tolerability in Advanced Colorectal Cancer - Doctor's Guide, 10/25/01
• Xeloda (Capecitabine)/Eloxatin (Oxaliplatin) Combo Highly Effective in Colorectal Cancer - Doctor's Guide, 10/24/01
• FDA Grants Fast Track Status to Cancer Vaccine, Oncophage (HSPPC-96) - Doctor's Guide, 10/12/01
• Older Colon Cancer Patients Should Receive Same Treatment - WebMD, 10/10/01
• An InteliHealth/Harvard Look At The News -- Colon Cancer Tests - Intelihealth, 8/23/01
• Colorectal Cancer Tests Are Not Created Equal - WebMD, 8/22/01
• American Medical Association Announces New Screening/Surveillance Guidelines for Colorectal Cancer - Doctor's Guide, 7/20/01
• Better Response Rate With Irinotecan + 5-FU + Irradiation In Rectal Cancer Patients - Doctor's Guide, 6/27/01
• Study Suggests Link Between Processed Meat And Cancer But Not Fresh Red Meat - Intelihealth, 6/22/01 - "Eating lots of preserved meats such as salami, bacon, cured ham and hot dogs could increase the risk of bowel cancer by 50 percent"
• Viagra (Sildenafil) Effective For Erectile Dysfunction Associated with Rectal Cancer - Doctor's Guide, 6/7/01
• Chemotherapy and Radiation Just as Effective as Surgery in Some Rectal Cancers - Doctor's Guide, 6/5/01
• Virtual Colonoscopy May Provide Effective Alternative To Invasive Colonoscopy - Doctor's Guide, 5/30/01
• Colon Cancer Treatment May Be More Toxic Than Thought, Triple-Drug Therapy Causes Severe Side Effects, Death - WebMD, 5/17/01
• Tests On Cancer Drug Suspended Over Toxicity Findings - Intelihealth, 5/17/01
• Theratope Vaccine Lengthens Survival In Colorectal Cancer Patients - Doctor's Guide, 5/15/01
• CancerVax Therapeutic Vaccine Induces Strong Immune Response In Late Stage Colorectal Cancer - Doctor's Guide, 5/15/01
• Blood Test Predicts Colon Cancer Response To Chemotherapy Pill, Xeloda (Capecitabine) - Doctor's Guide, 5/14/01
• Colon cancer drug may shrink tumors, extend lives - CNN, 5/14/01 - "In a study of 121 patients with end-stage colon cancer that didn't respond to chemotherapy, one out of five saw their tumors treated with C225 shrink by 50 percent or more ... C225, delivered intravenously, works by limiting a cancer cell's access to growth factor, which many cells need to survive. That makes the cancer cells weaker, and therefore more vulnerable to chemotherapy"
• Doctors Encouraged By Cancer Drug - Intelihealth, 5/13/01 - "they expect the medicine to become a standard treatment for colon cancer and probably other tumors, as well ... The latest treatment, code-named IMC-C225, produced no cures, but it did shrink tumors by at least half in nearly one-quarter of patients with end-stage colon cancer"
• Antibody IMC-C225 Appears Promising In Refractory Colorectal Patients - Doctor's Guide, 5/12/01
• FDA Approves First Oral Drug for Colorectal Cancer, Xeloda Lets Patients Avoid Needles, Hospital Visits, Hair Loss - WebMD, 5/1/01
• FDA Approves Xeloda (Capecitabine), First Oral Chemotherapy for Treatment of Colorectal Cancer - Doctor's Guide, 5/1/01
• Oral Contraceptive Use May Lower Colorectal Cancer Risk - WebMD, 4/19/01 - "Combined findings from several studies point to a lower risk of colorectal cancer in women who have used oral contraceptives"
• The pill might protect against colon cancer - USA Today, 4/16/01
• Study Indicates Contraceptive Might Protect Women From Bowel Cancer - Intelihealth, 4/16/01 - "women had about a 20 percent lower chance of developing the disease if they used oral contraceptives"
• Chemotherapy pill causes fewer side effects - CNN, 4/13/01 - ""Toxicity was substantially less with pills. The risk of hospitalization was 20 percent with the IV drug; 11 percent with the pill. Nausea, hair loss and diarrhea were lessened by the pill, too." He added that the treatment is more convenient and less toxic than intravenous chemotherapy."
• Hormone Replacement Therapy Not Beneficial In Preventing Polyp Recurrence - Doctor's Guide, 3/28/01
• Synergistic Effect Seen With Irinotecan (CPT-11) And Oxaliplatin In Combination And Sequentially - Doctor's Guide, 3/26/01
• Patients Prefer New Oral Chemotherapy For Colorectal Cancer - Doctor's Guide, 3/9/01
• Over 50? Schedule Your Colon Cancer Screening - WebMD, 3/8/01
• Researchers Discover New Ways to Predict Advanced Colorectal Cancer Risk - Doctor's Guide, 2/13/01
• Cigarette smoking linked to colorectal cancer - CNN, 12/6/00
• Virtual Colonoscopy Found Highly Accurate For Cancer Detection, Staging - Doctor's Guide, 11/27/00
• There's Something Fruits and Veggies Appear Not to Prevent - WebMD, 10/31/00
• COX-2 Inhibitors Shown Effective For Reducing Risk of Colon Cancer - Doctor's Guide, 10/18/99
• New Colon Cancer Test Developed - Intelihealth, 10/26/00
• Experimental Test for Colon Cancer Is Painless, Faster - WebMD, 10/24/00
• DNA testing may help detect colon cancers earlier - CNN, 10/24/00
• SU5416 Showing Promise in Controlling, Shrinking Colorectal Cancer Tumors - Doctor's Guide, 10/13/00
• New Drug For Colorectal Cancer, Plus Standard Ones, Improves Survival - Intelihealth, 9/28/00
• New Hope for Colon Cancer Patients - WebMD, 9/27/00
• Lighting Up May Be Hazardous to Your Colon - WebMD, 7/21/00
• Sigmoidoscopy May Miss Cancer - Intelihealth, 7/20/00
• Surgical Technique May Catch Spread of Colon Cancer Earlier - Doctor's Guide, 7/6/00
• New Prevention Weapon for Those at Risk for Colon Cancer - WebMD, 6/29/00
• CT Scans Improve Disease Management In Colon Cancer - Doctor's Guide, 6/29/00
• Studies Suggest Possible Role Of COX-2 Inhibitor For Familial Adenomatous Polyposis - Doctor's Guide, 6/2/00
• Experimental Drug Strangles Cancer's Blood Supply - WebMD, 5/23/00
• FDA Approves Camptosar (Irinotecan Hydrochloride) In Combo Therapy For Metastatic Colorectal Cancer - Doctor's Guide, 4/24/00
• FDA OKs Colorectal Cancer Treatment - Intelihealth, 4/21/00
• Diet's Anti-Cancer Benefits Doubted - Intelihealth, 4/20/00
• Patients With Metastatic Colorectal Cancer May Benefit From Xeloda (Capecitabine) - Doctor's Guide, 4/19/00
• Camptosar (Irinotecan) In Combo Therapy Improves Survival In Metastatic Colorectal Cancer - Doctor's Guide, 3/27/00
• Laparoscopic Surgery For Diagnosing Colon Cancer Not Yet Proven Beneficial - Doctor's Guide, 3/21/00
• FDA Committee Recommends Camptosar (Irinotecan) For Colorectal Cancer - Doctor's Guide, 3/17/00
• Combined Therapies Increase Life Expectancy With Metastatic Colorectal Cancer - Doctor's Guide, 12/30/99
• Chemo And Radiation Cut Liver Metastases - Doctor's Guide, 11/2/99
• Estrogen Reduces Risk Of Colorectal Cancer - Doctor's Guide, 10/28/99
• Aptosyn Effective In Preventing Pre-cancerous Colon Polyps - Doctor's Guide, 10/28/99
• Celecoxib Reduces Number And Size Of Colorectal Polyps - Doctor's Guide, 10/21/99
• How Sulindac Prevents Colon-Cancer - Doctor's Guide, 9/20/99
• New Data Demonstrates Survival Benefits Of Camptosar In Colon Cancer - Doctor's Guide, 9/17/99
• FDA Advisory Committee Recommends UFT Plus Leucovorin For Colorectal Cancer - Doctor's Guide, 9/16/99
• Colorectal cancer: Find it before it finds you - CNN, 6/14/99
• Breast Cancer Drug (Xeloda (capecitabine))Works In Colon - Doctor's Guide, 5/19/99
• Orzel Significantly Safer Than Traditional IV Treatment For Colorectal Cancer - Doctor's Guide, 5/17/99
• Colon cancer vaccine appears to prevent recurrence - CNN, 1/28/99
• Estrogen May Reduce Colorectal Cancer Risk In Postmenopausal Women - Doctor's Guide, 9/24/98
• Scientists Discover New Link To Colon Cancer - Doctor's Guide, 7/21/98
• Link Shown Between Insulin Resistance, Colon And Breast Cancer - Doctor's Guide, 6/12/97 - "Results showed that nearly 27 percent of the women who died from colon cancer had insulin resistance, compared to 3 percent of the controls"

Related Searches:

• Doctor's Guide search of colon cancer
• Doctor's Guide (2) search of colon cancer
• Intelihealth search of colon cancer
• Life Extension Foundation search
• Medline search of colon cancer
• Medscape search of colon cancer
• Google search of colon cancer
• The Natural Pharmacist search of colon cancer
• Nutrition Science News search
• WebMD search of colon cancer

Related Sites:

• Colon Cancer Alliance
• Colon Cancer Information Library
• Jackson Gastro
• WebMD colon cancer page

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