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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
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Health Conditions > Colon Cancer.
Colon Cancer
Popular Supplements:
Alternative News:
-
The Omega-3
Polyunsaturated Fatty Acid Eicosapentaenoic Acid Inhibits Mouse MC-26 Colorectal
Cancer Cell Liver Metastasis Via Inhibition Of Prostaglandin E(2) -Dependent
Cell Motility - Br J Pharmacol. 2012 Feb 2 -
"Treatment with 5% (w/w) EPA-FFA was associated with a reduced MC-26 mouse CRC
cell liver tumour burden compared with control animals (median liver weight
1.62g versus 1.03g; P < 0.034). Administration of 5% EPA-FFA was also linked to
a significant increase in tumour EPA incorporation and lower intra-tumoral
PGE(2) levels (with concomitant increased production of PGE(3) ). Liver tumours
from 5% EPA-FFA treated mice demonstrated decreased bromodeoxyuridine-positive
CRC cell proliferation and reduced phosphorylated extracellular signal-related
kinase 1/2 expression at the invasive edge of tumours. A concentration-dependent
reduction in MC-26 CRC cell Transwell® migration following EPA-FFA treatment
(50-200µM) in vitro was rescued by exogenous PGE(2) (10µM) and PGE(1) -alcohol
(1µM). Conclusions: EPA-FFA inhibits MC-26 CRC cell liver metastasis. EPA
incorporation is associated with a 'PGE(2) to PGE(3) switch' in liver tumours.
Inhibition of PGE(2) -EP4 receptor-dependent CRC cell motility likely
contributes to the anti-neoplastic activity of EPA" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb.
-
Regular
use of vitamin and mineral supplements could reduce the risk of colon cancer,
study suggests - Science Daily, 2/3/12 - "Rats fed a
high-fat plus low-fibre diet and exposed to carcinogens developed pre-cancerous
lesions; whereas, rats undergoing similar treatment, but provided with daily
multivitamin and mineral supplements, showed a significant (84%) reduction in
the formation of pre-cancerous lesions and did not develop tumours ... The
authors conclude that "multivitamin and mineral supplements synergistically
contribute to the cancer chemopreventative potential"
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Fish Oil
Supplement Alters Markers of Inflammatory and Nutritional Status in Colorectal
Cancer Patients - Nutr Cancer. 2012 Feb 1 - "The
supplemented group (SG) consumed 2 g of fish oil containing 600 milligrams of
eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for 9 wk ... Patients
supplemented with fish oil (SG) showed a clinically relevant decrease in the
C-reactive protein/albumin relation (P = 0.005). Low doses of fish oil
supplement can positively modulate the nutritional status and the C-reative
protein/albumin ratio" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb.
-
Dietary
intake of PUFAs and colorectal polyp risk - Am J Clin Nutr. 2012 Jan 25 -
"n-6 PUFAs were not associated with adenomatous or
hyperplastic polyps in either men or women. Marine-derived n-3 PUFAs were
associated with reduced risk of colorectal adenomas in women only, with an
adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake
compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of
α-linolenic acid was associated with an increased risk of hyperplastic polyps in
men (P-trend = 0.03), which was not seen in women" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb.
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Preoperative
Probiotics Decrease Postoperative Infectious Complications of Colorectal Cancer
- Am J Med Sci. 2011 Dec 23 - "The preoperative oral
bifid triple viable probiotics minimize the postoperative occurrence of
infectious complications, with possible mechanisms attributed to the maintenance
of the intestinal flora and restriction of bacterial translocation from the
intestine. It was representative of the enhancement of systemic/localized
immunity and concurrent attenuation of systemic stress response" - See
probiotic products at iHerb
.
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Repeated
measurements of serum carotenoid, retinol and tocopherol levels in relation to
colorectal cancer risk in the Women's Health Initiative - Eur J Clin Nutr.
2011 Dec 14 - "Previous cohort studies examining the
association of serum antioxidant levels and risk of colorectal cancer have used
a single (baseline) measurement only. In the present study, we assessed the
association of serum levels of eight antioxidant nutrients in relation to risk
of colorectal cancer, using repeated measurements ... Serum antioxidants
measured at baseline generally showed no association with risk of colorectal
cancer, although serum β-carotene at baseline showed a non-significant inverse
association with colon cancer alone. Furthermore, using the repeated
measurements of β-carotene, the average of all measurements was inversely
associated with risk of both colorectal and colon cancer: HRs for highest vs
lowest tertile 0.54, 95% CI 0.31-0.96, and 0.47, 95% CI 0.25-0.88, respectively.
No associations were seen with other antioxidant nutrients in the repeated
measure analyses" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex, 60 Softgels
at iHerb
.
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High-Fiber Diet Linked to Lower Colon Cancer Risk - WebMD, 11/11/11 -
"Total fiber intake, as well as fiber from whole grains
and from cereals, was most strongly linked with a reduction in colorectal cancer
risk ... The evidence was weaker for fiber from fruits, vegetables, and legumes"
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Health
risk from eating well-done meat may be underestimated - Science Daily,
11/1/11 - "the incidence of intestinal tumours increased
from 31 per cent to 80 per cent in "human-like" mice who consumed substances
from meat crust (i.e. the surface formed during heat-treatment) ...
Heat-processing of food can lead to the formation of carcinogenic substances.
The formation of carcinogenic substances -- so-called food mutagens -- usually
occurs at high temperatures when frying or grilling"
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Dietary
patterns may be linked to increased colorectal cancer risk in women -
Science Daily, 10/24/11 - "High red meat intake, fish
intake, sugar-sweetened beverage intake, but low coffee, whole grains and
high-fat dairy intake, when taken as a whole, seemed to be associated with
higher levels of C-peptide in the blood ... C-peptide is a marker of insulin
secretion that can be measured in a person's blood. High levels of insulin may
promote cell growth and multiplication. One of the major characteristics of
cancer is aberrant cell growth. Higher levels of C-peptide, and therefore
insulin, may promote cancer cell growth ... Colon cancer seems to be one of the
cancers that are sensitive to insulin ... women who most often consumed high
amounts of red meat, fish and sugar-sweetened beverages and low amounts of
high-fat dairy, coffee and whole grains had a 35 percent increased risk for
colorectal cancer"
-
Oral
inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour
growth both in segmental orthotopic colon cancer and extra-intestinal tissue
- Br J Nutr. 2011 Sep 30:1-12 - "Modulation of the
cellular response by the administration of probiotic bacteria may be an
effective strategy for preventing or inhibiting tumour growth. We orally
pre-inoculated mice with probiotics Lactobacillus acidophilus NCFM (La) for 14
d. Subcutaneous dorsal-flank tumours and segmental orthotopic colon cancers were
implanted into mice using CT-26 murine colon adenocarcinoma cells. On day 28
after tumour initiation, the lamina propria of the colon, mesenteric lymph nodes
(MLN) and spleen were harvested and purified for flow cytometry and mRNA
analyses. We demonstrated that La pre-inoculation reduced tumour volume growth
by 50.3 %, compared with untreated mice at 28 d after tumour implants (2465.5 (sem
1290.4) v. 4950.9 (sem 1689.3) mm3, P < 0.001)" - See
probiotic products at iHerb.

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Low-Dose
Dietary Resveratrol Has Differential Effects on Colorectal Tumorigenesis in
Adiponectin Knockout and Wild-Type Mice - Nutr Cancer. 2011 Sep 29 -
"Obesity is associated with a decrease in the antiinflammatory hormone,
adiponectin, and increases in the circulating concentrations of multiple
proinflammatory cytokines. These changes contribute to colon tumorigenesis.
Resveratrol increases adiponectin production in adipocytes and attenuates the
development of colon cancer. Thus, we hypothesized that adiponectin is an
integral component of the mechanism by which resveratrol antagonizes colorectal
tumorigenesis. To investigate this, we induced tumorigenesis in adiponectin
knockout (KO) and wild-type (Wt) C57BL/6 mice through combined azoxymethane and
dextran sodium sulfate treatment during which mice were fed a high-fat,
lard-based diet, or the same diet containing 20 mg/kg resveratrol. After 14 wk
on diet, Wt mice gained more weight and, on a percentage basis, had higher fat
mass and lower lean mass than KO mice. Resveratrol tended to attenuate this
response in male Wt mice. Resveratrol also tended to reduce aberrant crypt foci
development and decrease circulating interleukin 6 and insulin concentrations in
male but not female Wt mice. Taken together, resveratrol improved overall health
of obese Wt but not KO mice as hypothesized with a differential sex response" -
See
resveratrol products at iHerb.

-
Inhibitory
effects of resveratrol and pterostilbene on human colon cancer cells: a side by
side comparison - J Agric Food Chem. 2011 Sep 20 - "Cell viability tests
indicated that IC50s of pterostilbene were 2~5-fold lower than those of
resveratrol in all three cancer cells. Pterostilbene was also more potent in
inhibiting colony formation of all three cancer cells. Annexin V/Propidium
Iodide (PI) co-staining assay and western blotting analysis showed pterostilbene
had stronger apoptosis-inducing effects, which was evidenced by the higher
percentage of annexin V positive cells and higher levels of cleaved caspae-3 and
Poly (ADP-ribose) polymerase (PARP) proteins in cancer cells treated with
pterostilbene than resveratrol. High performance liquid chromatography (HPLC)
analysis demonstrated that intracellular levels of pterostilbene were 2~4-fold
higher than those of resveratrol after treatments with individual compounds at
the same concentration. Overall, our results demonstrated that pterostilbene had
more potent inhibitory effects on colon cancer cells than resveratrol, which may
be associated with the superior bioavailability of pterostilbene to resveratrol"
- See
pterostilbene products at iHerb.

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The effects
of metformin on the survival of colorectal cancer patients with diabetes
mellitus - Int J Cancer. 2011 Sep 12 - "Metformin
use has been associated with decreased cancer risk and mortality ... We
identified 595 patients who were diagnosed both CRC and diabetes mellitus.
Patients were compared by two groups; 258 diabetic patients taking metformin and
337 diabetic patients not taking metformin ... After a median follow-up of 41
months, there were 71 total deaths (27.5%) and 55 CRC-specific deaths (21.3%)
among 258 patients who used metformin, compared with 136 total deaths (40.4%)
and 104 CRC-specific deaths (30.9%) among 337 patients who did not use
metformin. Metformin use was associated with decreased overall mortality
(P=0.018) and CRC-specific mortality (P=0.042) by univariate analysis. After
adjustment for clinically relevant factors, metformin use showed lower risk of
overall mortality (HR, 1.45; 95% CI, 1.084-1.934; P=0.016) and CRC-specific
mortality (HR, 1.44; 95% CI, 1.026-2.061; P=0.035) in CRC patients with
diabetes. Metformin use in CRC patients with diabetes is associated with lower
risk of CRC-specific and overall mortality" - See
metformin at IAS.
-
Association
Between Vitamin D and Risk of Colorectal Cancer: A Systematic Review of
Prospective Studies - J Clin Oncol. 2011 Aug 29 - "Relevant studies were
identified by a search of MEDLINE and EMBASE databases before October 2010 with
no restrictions ... The pooled RRs of colorectal cancer for the highest versus
lowest categories of vitamin D intake and blood 25(OH)D levels were 0.88 (95%
CI, 0.80 to 0.96) and 0.67 (95% CI, 0.54 to 0.80), respectively. There was no
heterogeneity among studies of vitamin D intake (P = .19) or among studies of
blood 25(OH)D levels (P = .96). A 10 ng/mL increment in blood 25(OH)D level
conferred an RR of 0.74 (95% CI, 0.63 to 0.89) ... Vitamin D intake and blood
25(OH)D levels were inversely associated with the risk of colorectal cancer in
this meta-analysis" - See
vitamin D products at iHerb.

-
Confirmation that vitamin D acts as a protective agent against the advance of
colon cancer - Science Daily, 8/16/11 - "A study conducted by VHIO
researchers confirms that a lack of vitamin D increases the aggressiveness of
colon cancer ... In light of these findings, chronic vitamin D deficiency
represents a risk factor in the development of more aggressive colon tumours.
Patients in the initial stages of colon cancer, the time when the VDR still has
a substantial presence in the cells, could benefit from being treated with
vitamin D3. However, this would not be useful in the advanced stages of the
disease when the presence of the VDR is very much reduced" - See
vitamin D products at iHerb.

-
Cooked
Green Vegetables, Dried Fruit, Legumes, and Brown Rice Associated With Fewer
Colon Polyps - Science Daily, 8/2/11 - "Eating
legumes at least three times a week and brown rice at least once a week was
linked to a reduced risk of colon polyps by 33 percent and 40 percent
respectively ... Results also show that consuming cooked green vegetables once a
day or more, as compared to less than five times a week, was associated with a
24 percent reduction in the risk of rectal/colon polyps. Consuming dried fruit
three times a week or more, versus less than once a week, was associated with a
26 percent reduced risk"
-
S-allylmercaptocysteine
effectively inhibits the proliferation of colorectal cancer cells under in vitro
and in vivo conditions - Cancer Lett. 2011 Jun 30 - "S-allylmercaptocysteine
(SAMC), one of the water-soluble organosulfur garlic derivatives, has been
demonstrated as a suppressive agent against some tumors. The effects of SAMC on
the proliferation and metastasis of colorectal cancer (CRC) under in vitro and
in vivo conditions were evaluated here. The viabilities and migrations of CRC
cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT,
scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC
against luciferase-expressing SW620 xenografts in mice was determined by
bioluminescence imaging and histopathology observation. The apoptosis of
SAMC-treated CRC cells was examined by Western blotting. The results demonstrate
that SAMC could effectively suppress the growth and metastasis of colorectal
cancer cells both in vivo and in vitro. The anticancer effect of SAMC was
related to the decreased proliferation and increased apoptosis as well as
necrosis of cancer cells. Oral administration of SAMC in the
quantity/concentration used had no apparent toxic side effect on the vital
organs of the experimental mice. Taken together, the proliferation and
metastasis of CRC cells can be significantly suppressed by SAMC treatment under
both in vitro and in vivo conditions. SAMC may thus be a promising candidate for
CRC chemotherapy" - See
garlic products at iHerb.

-
Colon
cleansing has no benefit but many side effects including vomiting and death,
doctors say - Science Daily, 8/1/11 - "while these
reports show little evidence of benefit, there is an abundance of studies noting
side effects following the use of cleansing products including cramping,
bloating, nausea, vomiting, electrolyte imbalance and renal failure ... Some
herbal preparations have also been associated with aplastic anemia and liver
toxicity ... organizations such as the National Board for Colon Hydrotherapy and
others who promote colon cleansing require hygienists to have little more than a
high school diploma"
-
High
folate intake may reduce risk of colorectal cancer - Science Daily, 7/5/11 -
"We found that all forms and sources of folate were associated with lower risk
of colorectal cancer ... A research team investigated the association between
folate intake and colorectal cancer among 99,523 participants in the Cancer
Prevention Study II Nutrition Cohort; a total of 1,023 participants were
diagnosed with colorectal cancer between 1999 and 2007 ... The study also
addressed concerns that the intake of high levels of folate frequently consumed
in the U.S. -- as a result of the recent increase in the use of
folate-containing supplements and mandatory folate fortification of food -- may
actually increase risk of cancer. No increased risk of colorectal cancer was
found for the highest intake levels, suggesting that the high levels of this
vitamin consumed by significant numbers of Americans should not lead to
increased incidence rates of this cancer in the population" - See
folic acid products at iHerb.

-
Boswellic
acid inhibits growth and metastasis of human colorectal cancer in orthotopic
mouse model by downregulating inflammatory, proliferative, invasive, and
angiogenic biomarkers - Int J Cancer. 2011 Jun 23 - "We found that the oral
administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of
CRC tumors in mice, resulting in decrease in tumor volumes than those seen in
vehicle-treated mice without significant decreases in body weight. In addition,
we observed that AKBA was highly effective in suppressing ascites and distant
metastasis to the liver, lungs, and spleen in orthotopically-implanted tumors in
nude mice. When examined for the mechanism, we found that markers of tumor
proliferation index Ki-67 and the microvessel density CD31; were significantly
downregulated by AKBA treatment. We also found that AKBA significantly
suppressed NF-κB activation in the tumor tissue and expression of
pro-inflammatory (COX2), tumor survival (bcl-2, bcl-xL, IAP-1, survivin),
proliferative (cyclin D1), invasive (ICAM-1, MMP-9) and angiogenic (CXCR4 and
VEGF) biomarkers. When examined for serum and tissue levels of AKBA, a
dose-dependent increase in the levels of the drug was detected, indicating its
bioavailability. Thus, our findings suggest that this boswellic acid analogue
can inhibit the growth and metastasis of human CRC in vivo through
downregulation of cancer-associated biomarkers" - See
boswellia products at iHerb.

-
Strong
Evidence Links Meat to Higher Risk for Colon Cancer - Medscape, 5/30/11 -
"For red and processed meat, the findings from 10 new
studies were added to the 14 studies that were evaluated in the 2007 report.
From these 24 studies, the panel confirmed that there is convincing evidence
that both red and processed meat can increase the risk for colorectal cancer ...
The WCRF/AICR recommend that the consumption of red meat be limited to 500
g/week, which is roughly the equivalent of 5 or 6 medium portions of beef, lamb,
or pork. They also recommend that processed meat be avoided ... According to
their data, if 3.5 ounces of red meat are consumed every day (24.5 ounces per
week), the risk for colorectal cancer will be 17% higher than if no red meat is
consumed. If the amount of red meat consumed is doubled (7.0 ounces every day;
49 ounces per week), the risk is 34% higher. However, the evidence found that
there was very little increase in risk for individuals who ate less than 18
ounces of red meat per week ... The cancer risk associated with processed meat,
which includes ham, bacon, pastrami, hot dogs, and sausages, was much higher.
Consuming 3.5 ounces every day (24.5 ounces per week) was associated with a risk
that is 36% higher than the risk of consuming no processed meat. As with red
meat, the higher the rate of consumption, the higher the risk for colorectal
cancer"
-
Yogurt
consumption and risk of colorectal cancer in the italian EPIC cohort - Int J
Cancer. 2011 May 23 - "Yogurt intake was inversely
associated with CRC risk. For the energy-adjusted model, HR for CRC in the
highest vs. lowest tertile of yogurt intake was 0.62 (95%CI, 0.46-0.83). In the
full model adjusted for energy, simple sugar, calcium, fiber, animal fat,
alcohol, and red meat intake, as well as body mass index, smoking, education and
physical activity, HR was 0.65 (95%CI, 0.48-0.89) in the highest vs. lowest
tertile. The protective effect of yogurt was evident in the entire cohort, but
was stronger in men, although there was no interaction of sex with the
yogurt-CRC association (P-interaction 0.20, fully-adjusted model). In this
prospective study, high yogurt intake was significantly associated with
decreased CRC risk, suggesting that yogurt should be part of a diet to prevent
the disease" - Note: I started a web page
on just yoghurt instead of putting the yoghurt articles on my Pro-biotics
page. I also put my yoghurt recipe there. I nearly live on that
stuff because I have
trouble
swallowing after my neck cancer surgery
six and a half years ago.
-
Folic acid supplementation not associated with colon cancer: Meta-analysis -
Nutra USA, 5/9/11 - "New research analysing data from
the three largest trials of folic acid and the risk of colon cancer has
suggested that supplementation has no effect on the risk of developing the
disease ... Interestingly, we observed a potential beneficial effect of folic
acid supplements on overall mortality" - [Abstract]
-
Foods and
Food Groups Associated With the Incidence of Colorectal Polyps: The Adventist
Health Study - Nutr Cancer. 2011 May 4:1 -
"Colorectal cancer (CRC) is a leading cause of cancer death in the United
States. The majority of CRC arise in adenomatous polyps and 25-35% of colon
adenoma risk could be avoidable by modifying diet and lifestyle habits ...
Multivariate analysis adjusted by age, sex, body mass index, and education
showed a protective association with higher frequency of consumption of cooked
green vegetables (OR 1 time/d vs. <5/wk = 0.76, 95% CI = 0.59-0.97) and dried
fruit (OR 3+ times/wk vs. <1 time/wk = 0.76, 95%CI = 0.58-0.99). Consumption of
legumes at least 3 times/wk reduced the risk by 33% after adjusting for meat
intake. Consumption of brown rice at least 1 time/wk reduced the risk by 40%.
These associations showed a dose-response effect. High frequency of consumption
of cooked green vegetables, dried fruit, legumes, and brown rice was associated
with a decreased risk of colorectal polyps"
-
Canola
oil protects against colon cancer, study suggests - Science Daily, 4/19/11 -
"canola oil inhibited the average number of tumors per
rat by 58 percent compared to one of the other two control diets in the
experiment, and inhibited the size of the tumors that occurred by 90 percent ...
canola oil inhibited the average number of tumors per rat by 58 percent compared
to one of the other two control diets in the experiment, and inhibited the size
of the tumors that occurred by 90 percent ... studies have indicated that if
consumers use canola as household cooking oil, it could push their ratio of
Omega-6 to Omega-3 fatty acids to about 3 to 1. That's very desirable. Humans
need Omega-6 fatty acids, too, but they typically consume way too much of them
in countries such as the United States ... It should be less than 4 to 1. But in
a typical American diet, when we use other oil and butter, our ratio is 10 to 1
or higher. We consume a lot more Omega-6 than Omega-3 fatty acids"
-
Vitamin D
Status in Patients With Stage IV Colorectal Cancer: Findings From Intergroup
Trial N9741 - J Clin Oncol. 2011 Mar 21 - "Vitamin D
deficiency is highly prevalent among patients with stage IV colorectal cancer
receiving first-line chemotherapy, particularly in black and female patients"
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Pterostilbene ‘more potent than resveratrol’ for colon health: Study - Nutra
USA, 3/21/11 - "the chemopreventive effect of
pterostilbene was more potent than resveratrol and was associated with a
decreased inflammation as well as modulation of the antioxidant signaling
pathways in the colons of mice" - [Abstract]
- See
pterostilbene products at iHerb.

-
Pterostilbene ‘more potent than resveratrol’ for colon health: Study - J
Agric Food Chem. 2011 Mar 23;59(6):2725-33 - "Inflammatory bowel diseases have
been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS)
generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously,
resveratrol (RS) and pterostilbene (PS) had been reported to prevent
chemical-induced colon carcinogenesis by anti-inflammatory and pro-apoptotic
properties ... Administrations of PS can be more effective than RS in reducing
AOM-induced formation of aberrant crypt foci (ACF), lymphoid nodules (LNs), and
tumors. We also find that PS is functioning more effectively than RS to reduce
nuclear factor-κB (NF-κB) activation by inhibiting the phosphorylation of
protein kinase C-β2 (PKC-β2) and decreasing downstream target gene expression,
including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and
aldose reductase (AR) in mouse colon stimulated by AOM. Moreover, administration
of RS and PS for 6 weeks significantly enhanced expression of antioxidant
enzymes, such as heme oxygenase-1 (HO-1) and glutathione reductase (GR), via
activation of NF-E2-related factor 2 (Nrf2) signaling. When the above findings
are taken together, they suggest that both stilbenes block cellular inflammation
and oxidative stress through induction of HO-1 and GR, thereby preventing
AOM-induced colon carcinogenesis. In comparison, PS was a more potent
chemopreventive agent than RS for the prevention of colon cancer. This is also
the first study to demonstrate that PS is a Nrf2 inducer and AR inhibitor in the
AOM-treated colon carcinogenesis model" - See
pterostilbene products at iHerb.

-
Quercetin's
Effects on Intestinal Polyp Multiplicity and Macrophage Number in the Apc(Min/+)
Mouse - Nutr Cancer. 2011 Mar 1:1 - "Numerous in vitro studies argue for quercetin's chemopreventive potential in colon cancer; however, experimental
studies in rodents are limited. Macrophages play a role in tumorigenesis, but
the effects of quercetin on macrophage infiltration in colon cancer is unknown.
We examined the effects of quercetin on intestinal polyp multiplicity and
macrophage number in Apc(Min/+) mice ... These data suggest that quercetin can
reduce polyp number and size distribution in the Apc(Min/+) mouse and that these
effects may be related to a reduction in macrophage infiltration" - See
quercetin products at iHerb.

-
Exercise
Reduces Risk for Colon Polyps, Resulting in Less Colon Cancer - Medscape,
3/9/11 - "reanalyzed data collected in 20 clinical
trials that reported on physical activity levels (obtained mainly from
questionnaires) in individuals who had undergone sigmoidoscopy or colonoscopy
(both symptomatic and screening). Most studies did not specify the reason for
undergoing the procedure ... Together, these trials involved more than 250,000
individuals ... Overall, there was a significant inverse association between
physical activity and colon polyps (fixed-effect relative risk [RR], 0.87; 95%
confidence interval [CI], 0.83 to 0.91; random-effects RR, 0.84; 95% CI, 0.77 to
0.92) ... "Our meta-analysis found the effect was stronger, though not
significantly so, for large or advanced adenomas than for the overall effect,"
they add ... The risk reduction (RR, 0.83) was "largely unchanged" when the
analysis was restricted to the 18 studies in which the results for adenomatous
polyps were separated from all polyps (i.e., hyperplastic, malignant polyps),
they report"
-
Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D
receptor polymorphisms and colorectal cancer risk - Cancer Epidemiol
Biomarkers Prev. 2011 Mar 4 - "We observed inverse
associations of colorectal cancer risk with dietary vitamin D (summary RR per
100 IU/day=0.95 95%CI: (0.93-0.98); 10 studies; range of intake (midpoints) =
39-719 IU/day) and serum/plasma 25-hydroxyvitamin D (RR per 100 IU/l=0.96
(0.94-0.97); 6 studies; range=200-1800 IU/l), but not with total vitamin D (5
studies). Supplemental (2 studies; range=0-600 IU/day) and total (4 studies;
range=79-732 IU/day) vitamin D intake and 25-hydroxyvitamin D status (6 studies;
range=200-1800 IU/l) were inversely associated with colon cancer risk. We did
not observe statistically significant associations between FokI, PolyA, TaqI,
Cdx2 and ApaI VDR polymorphisms and colorectal cancer risk. The BsmI
polymorphism was associated with a lower colorectal cancer risk (RR=0.57
(0.36-0.89) for BB vs. bb, 8 studies)" - See
vitamin D products at iHerb.

-
Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane
(AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2
(Nrf2)-Mediated Antioxidant Signaling Pathway - J Agric Food Chem. 2011 Feb
28 - "Inflammatory bowel diseases have been a risk factor of
colorectal cancer
(CRC). The reactive oxygen species (ROS) generated by inflammatory cells create
oxidative stress and contribute to neoplastic transformation, proliferation, and
even metastasis. Previously, resveratrol (RS) and pterostilbene (PS) had been
reported to prevent chemical-induced colon carcinogenesis by anti-inflammatory
and pro-apoptotic properties ... Administrations of PS can be more effective
than RS in reducing AOM-induced formation of aberrant crypt foci (ACF), lymphoid
nodules (LNs), and tumors. We also find that PS is functioning more effectively
than RS to reduce nuclear factor-κB (NF-κB) activation by inhibiting the
phosphorylation of protein kinase C-β2 (PKC-β2) and decreasing downstream target
gene expression, including inducible nitric oxide synthase (iNOS),
cyclooxygenase-2 (COX-2), and aldose reductase (AR) in mouse colon stimulated by
AOM. Moreover, administration of RS and PS for 6 weeks significantly enhanced
expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and
glutathione reductase (GR), via activation of NF-E2-related factor 2 (Nrf2)
signaling. When the above findings are taken together, they suggest that both
stilbenes block cellular inflammation and oxidative stress through induction of
HO-1 and GR, thereby preventing AOM-induced colon carcinogenesis. In comparison,
PS was a more potent chemopreventive agent than RS for the prevention of colon
cancer. This is also the first study to demonstrate that PS is a Nrf2 inducer
and AR inhibitor in the AOM-treated colon carcinogenesis model"
-
Vitamin D linked to colon cancer protection: Meta-analysis - Nutra USA,
2/7/11 - "for every 10 nanograms per milliliter increase in 25(OH)D levels the
associated risk of colorectal cancer decreased by 15 percent, while the risk of
breast cancer was associated with an 11 percent decrease. However, when the
researchers restricted their analysis to prospective studies only, the breast
cancer risk was decreased by only 3 percent, whereas data from case-control
studies indicated a risk reduction of 17 percent" - See
vitamin D products at iHerb.

-
Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and
colorectal, breast and prostate cancer and colorectal adenoma - Int J
Cancer. 2011 Mar 15;128(6):1414-24 - "The summary
relative risk (SRR) and (95% confidence interval) for a 10 ng/ml increase in
serum 25-hydroxyvitamin D was 0.85 (0.79; 0.91) for colorectal cancer (2,630
cases in 9 studies); 0.89 (0.81;0.98) for breast cancer (6,175 cases in 10
studies); and 0.99 (0.95;1.03) for prostate cancer (3,956 cases in 11 studies).
For breast cancer, case-control studies (3,030 cases) had major limitations and
obtained SRR of 0.83 (0.79; 0.87) whereas SRR of prospective studies (3,145
cases) was 0.97 (0.92; 1.03). For colorectal and breast cancer, differences
between cases and controls in the season of blood draw or in overweight/obesity
or physical inactivity could not explain the results. In conclusion, a
consistent inverse relationship between serum 25-hydroxyvitamin D levels and
colorectal cancer was found. No association was found for breast and prostate
cancer" - See
vitamin D products at iHerb.

-
Folate
intake and risk of colorectal cancer and adenoma: modification by time - Am
J Clin Nutr. 2011 Jan 26
-
Chemopreventive Effects of Dietary Canola Oil on Colon Cancer Development -
Nutr Cancer. 2011 Jan 24:1 - "Dietary canola oil
significantly (P < 0.05) decreased colonic tumor incidence and tumor
multiplicity as compared to dietary corn oil in rats. Fatty acid analysis showed
that corn oil group had higher levels of ω-6 fatty acid levels, whereas the
canola oil groups exhibited higher levels of ω-3 fatty acids from the colon and
serum samples of rats. For the mechanistic study, COX-2 expression in the colon
samples from the canola oil group was significantly lower (P < 0.05) as compared
to the corn oil group. Taken together, dietary canola oil may be chemopreventive
for colon tumor development in Fischer rats as compared to possibly by
increasing ω-3 fatty acid levels and decreasing COX-2 levels"
-
Folic acid
and prevention of colorectal adenomas: A combined analysis of randomized
clinical trials - Int J Cancer. 2010 Dec 17 -
"Observational data suggest that lower folate status is associated with an
increased risk of colorectal neoplasia, implying that folate may be useful as a
chemopreventive agent. We conducted a combined analysis of three large
randomized trials of folic acid supplementation for the prevention of
metachronous adenomas in patients with an adenoma history. Participants included
2,632 men and women with a history of adenomas randomized to either 0.5 or 1.0
mg/day of folic acid or placebo, and who had a follow-up endoscopy 6 to 42
months after randomization ... The RR comparing folic acid vs. placebo was 0.98
(95% CI=0.82-1.17) for all adenomas and 1.06 (95% CI=0.81-1.39) for advanced
lesions. Folic acid was associated with a non-significant decreased risk of any
adenoma among subjects in the lowest quartile of baseline plasma folate (≤11
nmol/L) and no effect among individuals in the highest quartile (>29 nmol/L, p
for trend = 0.17). There was a non-significant trend of decreasing risk of any
adenoma associated with folic acid supplements with increasing alcohol intake.
During the early follow-up reported here, more deaths occurred in the placebo
group than in the folic acid group (1.7% vs. 0.5%, p=.002)"
-
Designer
probiotics could reduce obesity - Science Daily, 12/22/10 -
"engineered a strain of Lactobacillus to produce a
version of a molecule called conjugated linoleic acid (CLA). When this
engineered bacterial strain was fed to mice, the researchers found that the
composition of the mice's fat tissue was significantly altered ... One type,
called t10, c12 CLA, has been shown to be associated with decreased body fat in
humans and other animals. t10, c12 CLA also has the ability to inhibit the
growth of colon cancer cells and induce their death. However, this type of CLA
is only produced by certain types of bacteria including Propionibacterium acnes
-- a skin bacterium that can cause acne ... In this study, an enzyme-encoding
gene from P. acnes was transferred to the Lactobacillus strain allowing it to
produce t10, c12 CLA ... CLA has already been shown to alleviate non-alcoholic
fatty liver disease that often accompanies obesity. Therefore, increasing levels
of CLA in the liver by ingestion of a probiotic strain is of therapeutic
relevance ... The same group of researchers previously found that microbially
produced CLA was able to reduce the viability of colon cancer cells by 92%"
-
Dietary
Supplementation of Lutein Reduces Colon Carcinogenesis in DMH-Treated Rats by
Modulating K-ras, PKB, and β-catenin Proteins - Nutr Cancer. 2010 Dec 2:1 -
"The results showed a significant increase in protein expression for K-ras and
β-catenin in tumors of DMH-treated rats. Simultaneously, we detected changes in
the phosphorylation state of ERK1/2 and PKB in DMH-treated animals. Lutein given
in the diet (0.002%), before (prevention) and after (treatment) DMH
administration, diminished the number of tumors by 55% and 32%, respectively.
Moreover, lutein significantly decreased in tumors the expression of K-ras (25%)
and β-catenin (28%) and the amount of pPKB (32%), during the prevention, and
39%, 26%, and 26% during the treatment stage, respectively. This study
demonstrates the chemoprotective effect of lutein against colon cancer by
modulating the proliferative activity of K-ras, PKB, and β-catenin proteins" -
See
lutein products at iHerb.

-
Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and
Colo 205 Tumor Xenografts in Vivo - J Agric Food Chem. 2010 Nov 17 -
"capsaicin induced cytotoxic effects in a time- and
dose-dependent manner and increased reactive oxygen species (ROS) and Ca(2+)
but decreased the level of mitochondrial membrane potential (ΔΨ(m)) in colo
205 cells. Data from Western blotting analysis indicated that the levels of
Fas, cytochrome c, and caspases were increased, leading to cell apoptosis.
Capsaicin decreased the levels of anti-apoptotic proteins such as Bcl-2 and
increased the levels of pro-apoptotic proteins such as Bax.
Capsaicin-induced apoptosis in colo 205 cells was also done through the
activations of caspase-8, -9 and -3. In vivo studies in immunodeficient
nu/nu mice bearing colo 205 tumor xenografts showed that capsaicin
effectively inhibited tumor growth. The potent in vitro and in vivo
antitumor activities of capsaicin suggest that capsaicin might be developed
for the treatment of human colon cancer" - See
cayenne products at iHerb
.
-
NSAIDs cause stem cells to self-destruct, preventing colon cancer, study
finds - Science Daily, 11/1/10
-
Soy food
and isoflavone intake and colorectal cancer risk: the Fukuoka Colorectal
Cancer Study - Scand J Gastroenterol. 2010 Oct 24 -
"Energy-adjusted intakes of soy foods (dry weight)
and isoflavones were inversely associated with colorectal cancer risk in men
and postmenopausal women, but not in premenopausal women. The
multivariate-adjusted OR for the highest versus lowest quintile was 0.65
(95% CI 0.41-1.03, p for trend = 0.03) for soy foods and 0.68 (95% CI
0.42-1.10, p for trend = 0.051) for isoflavones in men. The corresponding
values for postmenopausal women were 0.60 (95% CI 0.29-1.25, p for trend =
0.053) and 0.68 (95% CI 0.33-1.40, p for trend = 0.049)"
-
Racial
disparity in death from colorectal cancer: does vitamin D deficiency
contribute? - Cancer. 2010 Oct 13 - "vitamin D
deficiency was associated significantly with CRC mortality (HR, 2.11; 95%
CI, 1.11-4.00), and the effect of race was decreased (HR, 1.60" - See
vitamin D products at iHerb
.
-
Allicin
purified from fresh garlic cloves induces apoptosis in colon cancer cells via
nrf2 - Nutr Cancer. 2010 Oct;62(7):947-57 - "Treatment with allicin resulted
in HCT-116 apoptotic cell death as demonstrated by enhanced hypodiploid DNA
content, decreased levels of B-cell non-Hodgkin lymphoma-2 (Bcl-2), increased
levels of bax and increased capability of releasing cytochrome c from
mitochondria to the cytosol. Allicin also induced translocation of NF-E2-related
factor-2 (Nrf2) to the nuclei of HCT-116 cells. Luciferase reporter gene assay
showed that allicin induces Nrf2-mediated luciferase transactivation activity.
SiRNA knock down of Nrf2 significantly affected the capacity of allicin to
inhibit HCT-116 proliferation. These results suggest that Nrf2 mediates the
allicin-induced apoptotic death of colon cancer cells" - See
garlic products at iHerb.

-
Clinical
Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients
- Cancer Res. 2010 Sep 14 - "Consumption of resveratrol reduced tumor cell
proliferation by 5% (P = 0.05). The results suggest that daily p.o. doses of
resveratrol at 0.5 or 1.0 g produce levels in the human gastrointestinal tract
of an order of magnitude sufficient to elicit anticarcinogenic effects.
Resveratrol merits further clinical evaluation as a potential colorectal cancer
chemopreventive agent" - See
resveratrol products at iHerb.

-
Even
very low dose of regular aspirin wards off bowel cancer, study finds -
Science Daily, 9/15/10 - "After a year, taking daily
low dose aspirin was associated with a 22% reduced risk of developing bowel
cancer, and the magnitude of the reduction in risk was cumulative, rising to
30% after five years ... taking NSAIDs of any kind did not influence the
risk of death from any cause nor did it increase bowel cancer survival"
-
Plasma
vitamins B2, B6, B12, and related genetic variants as predictors of
colorectal cancer risk - Cancer Epidemiol Biomarkers Prev. 2010 Sep 2 -
"Relative risks (RRs) ... Adjusted RRs comparing the
highest to lowest quintile (95% confidence interval, Ptrend) were: 0.71
(0.56-0.91, 0.02) for vitamin B2, 0.68 (0.53-0.87, <0.001) for vitamin B6,
and 1.02 (0.80-1.29, 0.19) for vitamin B12. The associations for vitamin B6
were stronger in males who consumed >/=30g alcohol/day. The polymorphisms
were not associated with CRC ... CONCLUSIONS: Results from this large
European cohort study show that higher plasma concentrations of vitamins B2
and B6 are associated with a lower CRC risk"
-
Metformin Might Prevent
Colorectal, Lung Cancers - Medscape, 9/3/10 - "The chance observation
that diabetes patients taking metformin have a 40% reduced risk for cancer
triggered intense research interest in this old off-patent drug ... After
about 10% of the mouse lifespan — about 12 weeks — with the highest dose in
the drinking water, we found a 33% reduction in tumor multiplicity and a 34%
reduction in tumor size in the mice. In mice that did not get metformin,
100% got tobacco carcinogen-induced lung tumors ... metformin might prevent
tumors by reducing levels of insulin and IGF-1" - See my
Insulin and Aging
page. There are a lot of studies pointing toward insulin being a major
cause of aging and caner. See
metformin at IAS.
-
Intake
of wholegrain products and risk of colorectal cancers in the Diet, Cancer
and Health cohort study - Br J Cancer. 2010 Aug 24;103(5):730-4 -
"wholegrain (WG) products ... Higher WG product
intake was associated with lower risk of colon cancer and rectal cancer in
men. The adjusted IRR (95% CI) was 0.85 (0.77-0.94) for colon cancer and
0.90 (0.80-1.01) for rectal cancer per daily 50 g increment in intake. For
colon cancer the association was confined to intake of WG bread in
particular. No consistent associations between total or individual WG
product consumption and colon or rectal cancer risk were observed in women"
-
More support for vitamin D’s colorectal protection - Nutra USA, 8/12/10 -
"In people using NSAIDs, the potential risk reduction of higher vitamin D levels
was increased to 66 per cent" - [Abstract]
- See
vitamin D products at iHerb.

-
Blood
25-Hydroxyvitamin D3 Concentrations and Incident Sporadic Colorectal Adenoma
Risk: A Pooled Case-Control Study - Am J Epidemiol. 2010 Jul 22 -
"In the
pooled analysis, higher circulating 25(OH)D(3) concentrations were statistically
significantly associated with decreased colorectal adenoma risk (highest vs.
lowest quartile odds ratio = 0.59, 95% confidence interval: 0.41, 0.84). The
observed inverse association was stronger among participants who used nonsteroidal antiinflammatory drugs regularly (highest vs. lowest quartile odds
ratio = 0.33, 95% confidence interval: 0.19, 0.56). Inverse associations between
25(OH)D(3) and colorectal adenoma did not differ substantially by other risk
factors or by adenoma characteristics. These findings support the hypothesis
that greater vitamin D exposure may reduce the risk of colorectal adenoma and
suggest that it may do so more strongly in combination with antiinflammatory
agents" - See
vitamin D products at iHerb.

-
Nutrient
dietary patterns and the risk of colorectal cancer: a case-control study from
Italy - Cancer Causes Control. 2010 Aug 1 - "Direct
associations were observed between the Starch-rich pattern and both cancer of
the colon (OR = 1.68) and of the rectum (OR = 1.74). Inverse relationships were
found between the Vitamins and fiber pattern and rectal cancer (OR = 0.61),
between the Unsaturated fats (animal source) and the Unsaturated fats (vegetable
source) and cancer of the colon (OR = 0.80 and OR = 0.79, respectively) ... The
Starch-rich pattern is potentially an unfavorable indicator of risk for both
colon and rectal cancer, whereas the Vitamins and fiber pattern is associated
with a reduced risk of rectal cancer and the Unsaturated fats patterns with a
reduced risk of colon cancer"
-
Gut
bacteria could be key indicator of colon cancer risk - Science Daily,
6/29/10 -
"a shift in the balance between the "good" bacteria and
the "bad" bacteria that populate our gut could be a harbinger of colon cancer
... We think something happens to tip the balance away from the beneficial
bacteria and in favor of microbes that make toxic metabolites and are
detrimental to our health ... By pinpointing these bacterial culprits, we can
not only identify people at risk, but also suggest that they include the good
bacteria in their diet .. And what a great way to address colon cancer -- you
could know your risk and lower it by eating your yogurt every day" -
Note: Dannon claims that only their Activia brand reaches the gut.
see:
- Activia by Dannon
- "Specialists at Dannon® selected Bifidus
Regularis™ for Activia® because it survives passage through the
digestive tract, arriving in the colon as a living culture. Once there,
it plays a beneficial role in your intestinal ecosystem"
-
Associations
of red meat, fat, and protein intake with distal colorectal cancer risk -
Nutr Cancer. 2010 Aug;62(6):701-9 - "There was no
association between total, saturated, or monounsaturated fat and distal CRC
risk. In African Americans, the OR of distal CRC for the highest category of
polyunsaturated fat intake was 0.28 (95% CI = 0.08-0.96). The percent of energy
from protein was associated with a 47% risk reduction in Whites (Q4 OR = 0.53,
95% CI = 0.37-0.77). Red meat consumption in Whites was associated with a
marginally significant risk reduction (Q4 OR = 0.66, 95% CI = 0.43-1.00). Our
results do not support the hypotheses that fat, protein, and red meat increase
the risk of distal CRC"
-
Prevention
of colorectal cancer with vitamin D - Scand J Gastroenterol. 2010 Apr 5 -
"On a molecular level, vitamin D suppresses CRC development and growth by
affecting cell proliferation, differentiation, apoptosis, and angiogenesis ...
Maintaining serum concentrations of calcidiol above 32 ng/ml (80 nmol/l) in
individuals whose serum calcidiol level is low may help prevent CRC as well as
osteoporosis, fractures, infections, and cardiovascular disease. Daily calcidiol
intake of 1000 International Units can increase serum vitamin D to sufficient
levels in most elderly persons and, based on available data, may substantially
lower the incidence of CRC with minimal risks" - See
vitamin D products at iHerb.

-
Eicosapentaenoic acid reduces rectal polyp number and size in familial
adenomatous polyposis - Gut. 2010 Mar 26 - "Treatment with EPA-FFA for 6
months was associated with a mean 22.4% (95% CI 5.1% to 39.6%) reduction in
polyp number (p=0.012) and a 29.8% (3.6% to 56.1%) decrease in the sum of polyp
diameters (p=0.027). Global polyp burden worsened over 6 months in the placebo
group (-0.34) unlike the EPA-FFA group (+0.09, difference 0.42 (0.10-0.75),
p=0.011) ... EPA-FFA has chemopreventative efficacy in FAP, to a degree similar
to that previously observed with selective cyclo-oxygenase-2 inhibitors. EPA
holds promise as a colorectal cancer chemoprevention agent with a favourable
safety profile" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb.
-
Vitamin
B6 and Risk of Colorectal Cancer: A Meta-analysis of Prospective Studies
- JAMA. 2010 Mar 17;303(11):1077-83 - "Omitting 1
study that contributed substantially to the heterogeneity among studies of
vitamin B(6) intake yielded a pooled RR of 0.80 (95% CI, 0.69-0.92). The
risk of colorectal cancer decreased by 49% for every 100-pmol/mL increase
(approximately 2 SDs) in blood PLP levels (RR, 0.51; 95% CI, 0.38-0.69)"
-
Omega 3
curbs precancerous growths in those prone to bowel cancer, study suggests -
Science Daily, 3/17/10 - "randomly assigned to six months of treatment with 2 g
daily of a new highly purified form of the omega 3 polyunsaturated fatty acid
(PUFA) EPA. The other 27 were given the same amount of a dummy treatment
(placebo) ...number of polyps increased by almost 10% among those treated with
the placebo, but fell by more than 12% among those treated with the EPA
capsules, representing a difference of almost 22.5% ... Similarly, polyp size
increased by more than 17% among those in the placebo group but fell by more
than 12.5% in those taking the EPA capsules, representing a difference of just
under 30% ... the effects of EPA were similar to those produced by celecoxib,
which is used to help curb the growth of new and existing polyps in patients
with FAP ... celecoxib has been associated with harmful cardiovascular side
effects in older patients" - See See
Mega Twin EPA at iHerb.

-
Magnesium may decrease colon cancer risk: Study - Nutra USA, 3/15/10 -
"Intakes of the mineral of at least 327 milligrams per day were found to reduce
the risk of colon cancer by 52 per cent, compared to intakes less than 238
milligrams per day, while no benefits were observed in women" - [Abstract]
- See
Jarrow Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.

-
High
Dietary Intake of Magnesium May Decrease Risk of Colorectal Cancer in Japanese
Men - J Nutr. 2010 Feb 17 - "When adjusted for potential confounders, the
hazard ratio and 95% CI in the highest quintile of magnesium intake compared
with the lowest quintile in men were 0.65 (95% CI, 0.40-1.03) for CRC (P-trend =
0.04), 0.48 (95% CI, 0.26-0.89) for colon cancer (P-trend = 0.01), and 0.97 (95%
CI, 0.47-2.02) for rectal cancer (P-trend = 0.93)" - See
Jarrow Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.

-
Synergistic
role of curcumin with current therapeutics in colorectal cancer: minireview
- Nutr Cancer. 2009 Nov;61(6):842-6 - "Despite the use of surgical resection and
aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma
develop recurrent disease, highlighting the need for improved therapies.
Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma
longa) with no discernable toxicity, has been shown to inhibit the growth of
transformed cells and colon carcinogenesis at the initiation, promotion, and
progression stages in carcinogen-induced rodent models. In a Phase I clinical
trial, curcumin has been found to be extremely well tolerated and effective ...
Existing data suggest that curcumin in combination with chemotherapy is a
superior strategy for treatment of gastrointestinal cancer" - See
curcumin/turmeric products at iHerb.

-
Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer
in Mice through Activation of PPAR{gamma} - J Nutr. 2010 Jan 20 -
"Conjugated linoleic acid (CLA) exerts a protective
effect on experimental inflammatory bowel disease and shows promise as a
chemopreventive agent against colorectal cancer (CRC) in mice, although the
mechanisms by which it exerts its beneficial effects against malignancies in
the gut are not completely understood ... Dietary CLA ameliorated disease
activity, decreased colitis, and prevented adenocarcinoma formation in the
PPARgamma-expressing floxed mice but not in the tissue-specific PPARgamma-null
mice. Dietary CLA supplementation significantly decreased the percentages of
macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype
and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but
not in the tissue-specific, PPARgamma-null mice. Colonic tumor necrosis
factor-alpha mRNA expression was significantly suppressed in CLA-fed,
PPARgamma-expressing mice. This study suggests CLA ameliorates colitis and
prevents tumor formation in part through a PPARgamma-dependent mechanism"
- See
CLA products at iHerb
.
-
Vitamin D May Lower Colon Cancer Risk - WebMD, 1/22/10 -
"They discovered that those with the highest blood
levels of vitamin D had a nearly 40% decrease in colorectal cancer risk than
those with the lowest levels" - [Science
Daily] - See
vitamin D products at iHerb
.
-
Antioxidant compound reduced incidence of colorectal metachronous adenomas
- Science Daily, 12/7/09 - "The researchers
randomized 411 participants to the placebo group or to receive an
antioxidant compound -- specifically selenomethionnine 200 μg, zinc 30 mg,
vitamin A 6,000 IU, vitamin C 180 mg and vitamin E 30 mg ... individuals who
consumed antioxidants had a 40 percent reduction in the incidence of
metachronous adenomas of the large bowel ... It is noteworthy that the
benefit observed after the conclusion of the trial persisted through 13
years of follow up"
-
Omega-3 fatty acids may reduce risk of colon cancer - Science Daily,
12/7/09 - "Patients who consumed more long-chain
omega-3 fatty acids had a reduced risk of distal large bowel cancer.
Compared to the lowest quartile, fat intake in the highest quartile was
linked with a 39 percent reduced risk of cancer" - See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Soy
component may be key to fighting colon cancer - Science Daily, 11/24/09
-
Citrus
fruit and cancer risk in a network of case-control studies - Cancer
Causes Control. 2009 Oct 24 - "The ORs for the
highest versus lowest category of citrus fruit consumption were 0.47 (95%
confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI,
0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95%
CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal
cancer"
-
Curcumin
synergizes with resveratrol to inhibit colon cancer - Nutr Cancer.
2009;61(4):544-53 - "the combination of curcumin and
resveratrol was found to be more effective in inhibiting growth of
p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and
in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either
agent alone. Analysis by Calcusyn software showed synergism between curcumin
and resveratrol. The inhibition of tumors in response to curcumin and/or
resveratrol was associated with the reduction in proliferation and
stimulation of apoptosis accompanied by attenuation of NF-kappaB activity.
In vitro studies have further demonstrated that the combinatorial treatment
caused a greater inhibition of constitutive activation of EGFR and its
family members as well as IGF-1R. Our current data suggest that the
combination of curcumin and resveratrol could be an effective
preventive/therapeutic strategy for colon cancer"
-
Dietary flavonoid intake and colorectal cancer: a case-control study -
Br J Nutr. 2009 Sep 7:1-8 - "We concluded that
flavonols, specifically quercetin, obtained from non-tea components of the
diet may be linked with reduced risk of developing colon cancer" -
See
quercetin products at iHerb
.
-
Green tea slashes heart disease death - Nutra USA, 9/8/09 -
"Compared to people who drank less than one cup a
day, seven or more cups of green tea a day may reduce the risk of dying from
heart disease by a whopping 75 per cent ... Additionally, a reduction in the
risk of colorectal cancer mortality of 31 per cent was observed for people
who drank more than seven cups of green a day, compared to people who frank
less than three cups a day" - [Abstract]
- See
Jarrow green tea extract at iHerb
.
-
Green Tea Consumption and Mortality among Japanese Elderly People: The
Prospective Shizuoka Elderly Cohort - Ann Epidemiol. 2009
Oct;19(10):732-739 - "The multivariate HRs and 95%
confidence intervals (CIs) for CVD mortality compared those who consumed
seven or more cups per day with those who consumed less than one cup per
day, were 0.24 (0.14-0.40), 0.30 (0.15-0.61), and 0.18 (0.08-0.40) for total
participants, men, and women, respectively. Although green tea consumption
was not inversely associated with cancer mortality, green tea consumption
and colorectal cancer mortality were inversely associated with a moderate
dose-response relationship" - See
Jarrow green tea extract at iHerb
.
-
Natural Compounds, Chemotherapeutic Drugs May Become Partners In Cancer
Therapy - Science Daily, 9/7/09 - "New research
shows that chlorophyllin -- a water-soluble derivative of chlorophyll, the
green pigment found in most plants -- may be 10 times more potent at killing
colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used
in cancer treatment" - See
chlorophyllin products at iHerb
.
-
Prebiotics may stop early stage colon cancer: Study - Nutra USA, 9/4/09
-
More omega-3, less omega-6 for colorectal protection - Nutra USA,
8/12/09 - "the dietary total omega-6 to omega-3 PUFA
ratio was strongly associated with colorectal cancer risk ... Compared to
women with the lowest ratio, women with the highest ratio of omega-6 to -3
had a relative risk 95 per cent higher" - [Abstract]
-
A
prospective study of dietary polyunsaturated fatty acids and colorectal
cancer risk in Chinese women - Cancer Epidemiol Biomarkers Prev. 2009
Aug;18(8):2283-91 - "The dietary total n-6 to n-3
PUFA ratio was strongly associated with colorectal cancer risk. Compared
with women in the lowest quintile group, elevated relative risks (RR) were
observed for the second [RR, 1.52; 95% confidence intervals (CI),
1.00-2.32], third (RR, 2.20; 95% CI, 1.41-3.45), fourth (RR, 1.65; 95% CI,
0.99-2.75), and fifth (RR, 1.95; 95% CI, 1.07-3.54) quintile groups.
Arachidonic acid was associated with colorectal cancer risk with elevated
RRs of 1.20(Q2-Q1) (95% CI, 0.87-1.64), 1.44(Q3-Q1) (95% CI, 1.05-1.98),
1.61(Q4-Q1) (95% CI, 1.17-2.23), and 1.39(Q5-Q1) (95% CI, 0.97-1.99;
P(trend) = 0.03) with increasing dietary quintile"
-
Aspirin May Help Treat Colon Cancer - WebMD, 8/10/09 -
"Certain patients with colorectal cancer who begin
regular aspirin use after the disease develops may greatly improve their
odds of survival ... Patients with colorectal cancer who started regular
aspirin use for the first time after diagnosis had a 47% lower risk of
colorectal cancer death and 32% lower risk of overall death than nonusers of
aspirin ... The survival advantage was seen only in those with
Cox-2-positive tumors. Most colorectal tumors are Cox-2-positive"
-
Curcumin
sensitizes human colorectal cancer to capecitabine by modulation of cyclin
D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model
- Int J Cancer. 2009 May 26 - "Because of the poor
prognosis and the development of resistance against chemotherapeutic drugs,
the current treatment for advanced metastatic colorectal cancer (CRC) is
ineffective. Whether curcumin (a component of turmeric) can potentiate the
effect of capecitabine against growth and metastasis of CRC was investigated
... In nude mice, the combination of curcumin and capecitabine was found to
be more effective than either agent alone in reducing tumor volume (p =
0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation
index (p = 0.001 vs. control) and microvessel density marker CD31. The
combination treatment was also highly effective in suppressing ascites and
distant metastasis to the liver, intestines, lungs, rectum and spleen. This
effect was accompanied by suppressed expression of activated NF-kappaB and
NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1,
COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that
curcumin sensitizes CRC to the antitumor and antimetastatic effects of
capecitabine by suppressing NF-kappaB cell signaling pathway" - See
curcumin/turmeric products at iHerb
.
-
Understanding The Anticancer Effects Of Vitamin D3 - Science Daily,
7/6/09 - "the active form of vitamin D3 directly
activates the CST5 gene in human colon cancer cell lines, increasing levels
of cystatin D protein. Functionally, cystatin D was shown to inhibit the
growth of human colon cancer cells lines in vitro and when they were
xenotransplanted into mice. As knocking down expression of cystatin D in
human colon cancer cell lines rendered them unresponsive to the
antiproliferative effects of the active form of vitamin D3, the authors
conclude that CST5 is a candidate tumor suppressor gene and that it mediates
a large proportion of the anticancer effects of the active form of vitamin
D3" - See
vitamin D products at iHerb
.
-
Folate linked to lower colorectal cancer risk: Study - Nutra USA, 7/6/09
- "A possible explanation for the contradictory
results of studies with the vitamin and colorectal cancer may be the
difference between the synthetic and natural forms of the vitamin. “The fact
that folic acid, which is not a naturally occurring form of the vitamin, is
used by food and pharmaceutical industries for fortification and
supplementation is potentially of importance,” wrote Tufts University’s
Mason in Nutrition Reviews ... On passage through the intestinal wall, folic
acid is converted to 5-methyltetrahydrofolate, the naturally circulating
form of folate. However, some studies have suggested that oral doses of
folic acid in high doses may overwhelm this conversion pathway, leading to
measurable levels of folic acid in the blood ... There has been some concern
that this oxidized, non-substituted form of folate might feasibly be
detrimental because it is not a naturally occurring co-enzymatic form of the
vitamin" - [Abstract]
-
Folate
intake and the risk of colorectal cancer in a Korean population - Eur J
Clin Nutr. 2009 Jun 24 - "Cases were more frequently
found to have a family history of CRC among first-degree relatives, to
consume more alcohol, to be more likely current smokers and less likely to
participate in vigorous physical activity than the controls. In the overall
data for men and women combined, multivariate ORs (95% confidence interval
(CI), P for trend) comparing the highest vs the lowest quartile of dietary
folate intake were: 0.47 (0.32-0.69, < 0.001) for CRC, 0.42 (0.26-0.69, <
0.001) for colon cancer and 0.48 (0.28-0.81, 0.007) for rectal cancer. An
inverse association was also found in women with dietary folate intake: 0.36
(0.20-0.64, < 0.001) for CRC, 0.34 (0.16-0.70, 0.001) for colon cancer and
0.30 (0.12-0.74, 0.026) for rectal cancer, but not in men. In addition, the
total folate intake of women was strongly associated with a reduced risk of
rectal cancer (OR, 0.38; 95% CI, 0.17-0.88; P for trend=0.04). ... We found
a statistically significant relationship between higher dietary folate
intake and reduced risk of CRC, colon cancer and rectal cancer in women. A
significant association is indicated between higher total folate intake and
reduced risk of rectal cancer in women"
-
Fruit and veg may slash colorectal cancer risk: Study - Nutra USA,
5/11/09 - "Over 8.8 years of follow-up ... the
highest average intakes of fruit and vegetables was associated with a 14 per
cent reduction in colorectal cancer risk, and a 24 per cent reduction in the
risk of colon cancer" - [Abstract]
-
Fruit, vegetables, and colorectal cancer risk: the European Prospective
Investigation into Cancer and Nutrition - Am J Clin Nutr. 2009
May;89(5):1441-52 - "After an average follow-up of
8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and
vegetables was inversely associated with CRC in a comparison of the highest
with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75,
1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76;
95% CI: 0.63, 0.91; P for trend < 0.01). Only after exclusion of the first 2
y of follow-up were these findings corroborated by calibrated continuous
analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91,
1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The
association between fruit and vegetable consumption and CRC risk was inverse
in never and former smokers, but positive in current smokers. This modifying
effect was found for fruit and vegetables combined and for vegetables alone"
-
B6 may slash colorectal cancer risk: Harvard study - Nutra USA, 5/5/09 -
"increased intakes of vitamin B6 from dietary and
supplements may reduce the risk of colorectal cancer by over 20 per cent (Cancer
Epidemiol Biomarkers Prev., Vol. 17, pp.
171-182)"
-
Prospective study of plasma vitamin B6 and risk of colorectal cancer in men
- Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1197-202 -
"plasma PLP levels were significantly inversely
associated with risk of colorectal cancer; compared with men in the lowest
quartile, those with PLP in quartiles 2 to 4 had relative risks (95%
confidence interval) of 0.92 (0.55-1.56), 0.42 (0.23-0.75), and 0.49
(0.26-0.92; P(trend) = 0.01), respectively"
-
Olive Skins Provide Natural Defense Against Colon Cancer, Study Suggests
- Science Daily, 1/8/09
-
Fruit,
vegetables, and colorectal cancer risk: the European Prospective
Investigation into Cancer and Nutrition - Am J Clin Nutr. 2009 Apr 1 -
"After an average follow-up of 8.8 y, 2,819 incident
CRC cases were reported. Consumption of fruit and vegetables was inversely
associated with CRC in a comparison of the highest with the lowest EPIC-wide
quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04),
particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for
trend < 0.01). Only after exclusion of the first 2 y of follow-up were these
findings corroborated by calibrated continuous analyses for a 100-g increase
in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI:
0.89, 0.99; P = 0.02), respectively. The association between fruit and
vegetable consumption and CRC risk was inverse in never and former smokers,
but positive in current smokers"
-
Prospective Study of Plasma Vitamin B6 and Risk of Colorectal Cancer in Men
- Cancer Epidemiol Biomarkers Prev. 2009 Mar 31 -
"plasma PLP levels were significantly inversely associated with risk of
colorectal cancer; compared with men in the lowest quartile, those with PLP
in quartiles 2 to 4 had relative risks (95% confidence interval) of 0.92
(0.55-1.56), 0.42 (0.23-0.75), and 0.49 (0.26-0.92; Ptrend = 0.01),
respectively. In conclusion, vitamin B6 may protect against colorectal
cancer independent of other one-carbon metabolites and inflammatory
biomarkers"
-
Effects
of resveratrol analogs on cell cycle progression, cell cycle associated
proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells
- Int J Cancer. 2009 Jan 13 - "Thus, acetylated
derivatives of resveratrol have retained the cytostatic and cytotoxic
activities of the parental molecule and thus deserve to be tested as
chemosensitizers in animal models" - See
Jarrow Resveratrol 100 at iHerb
.
-
Effects
of dietary flaxseed on intestinal tumorigenesis in apc(min) mouse - Nutr
Cancer. 2009;61(2):276-83 - "COX-1 and COX-2
expression in the colon samples from the flaxseed meal group were
significantly lower (P < 0.05) as compared to the corn meal group. Dietary
flaxseed may be chemopreventive for intestinal tumor development in Apc(Min)
mice possibly by increasing omega -3 fatty acid levels, lignans, and
decreasing COX-1 and COX-2 levels"
-
Selenium, folate, and colon cancer - Nutr Cancer. 2009;61(2):165-78 -
"High levels of serum selenium and reported folate
jointly were associated with a substantially reduced risk of colon cancer"
-
Calcium May Cut Cancer Risk - WebMD, 2/23/09 -
"older men and women who got the most calcium from food and supplements had
a 16% lower risk of colorectal and other cancers of the digestive system
than those who got the least calcium"
-
Effect
of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and
Tissue Damage in a DSS-Induced Colitis Rat Model - J Agric Food Chem.
2009 Feb 19 - "Resveratrol increased lactobacilli
and bifidobacteria as well as diminished the increase of enterobacteria upon
DSS treatment. Resveratrol significantly protected the colonic mucosa
architecture, reduced body weight loss, diminished the induced anemia and
reduced systemic inflammation markers, colonic mucosa prostaglandin E(2),
cycloxygenase-2, prostaglandin E synthase and nitric oxide levels. In
addition, the expression of 2,655 genes in distal colon mucosa related to
important pathways was varied. These results reinforce the concept of
resveratrol as a dietary beneficial compound in intestinal inflammation at
doses possibly attainable with resveratrol-enriched nutraceuticals" -
See
Jarrow Resveratrol 100 at iHerb
.
-
Cranberry extracts may prevent colon cancer: Lab study - Nutra USA,
2/13/09 - "These findings are important because they
demonstrate that the F-κB signalling pathway provides a potential
mechanistic link between inflammation and cancer and that the
anti-inflammatory properties of crude cranberry extract or quercetin can be
used to modulate this pathway" - See
Jarrow Formulas, Cran Clearance, 680 mg, 100 Capsules at iHerb
.
-
People Who Exercise Lower Their Risk Of Colon Cancer - Science Daily,
2/12/09 - "people who exercised the most were 24
percent less likely to develop the disease than those who exercised the
least"
-
Soy
Consumption Linked to Colorectal Cancer Risk in Postmenopausal Women -
Medscape, 1/29/09 - "For each 5-g/day increment in
dietary intake of soy as measured by dry weight (equivalent to approximately
1 oz [28.35 g] tofu/day), there was an 8% reduction in risk ... Compared
with women in the lowest tertile of soy intake, those in the highest tertile
had a multivariate relative risk (RR) of 0.67 ... were similar for soy
protein and isoflavone intakes"
-
Protective Effect of Fish Consumption on Colorectal Cancer Risk.
Hospital-Based Case-Control Study in Eastern Europe - Ann Nutr Metab.
2009 Jan 26;53(3-4):295-302 - "The adjusted OR
showed a significant reduction in CRC already at the moderate fish intake of
one or two servings per week (OR = 0.70; 95% CI: 0.51-0.94), but it was even
lower at higher fish intake (OR = 0.56; 95% CI: 0.39-0.86)"
- See
Mega Twin EPA at iHerb
and
Jarrow Max DHA at iHerb .
-
Fruit
and Vegetable Intakes Are Associated with Lower Risk of Colorectal Adenomas
- J Nutr. 2008 Dec 17 - "The odds ratio for upper
tertile intake compared with lower was 0.66 (95% CI = 0.51-0.86) for total
fruits, 0.64 (95% CI = 0.47-0.87) for berries, 0.72 (95% CI = 0.56-0.92) for
fruit juice, and 0.74 (95% CI = 0.58-0.96) for green vegetables. This study
provides additional evidence that high total fruit intake and certain fruit
and vegetable intakes may be associated with a reduced risk of colorectal
adenomas"
-
Vitamin D Can Alter Color Cancer Cells In Many Ways, Through One Pathway
- Science Daily, 11/17/08 - "Vitamin D can tame the
rogue cell by adjusting everything from its gene expression to its
cytoskeleton" - See
vitamin D products at iHerb
.
-
Calcium May Only Protect Against Colorectal Cancer In Presence Of Magnesium
- Science Daily, 11/16/08 - "supplementation of
calcium only reduced the risk of adenoma recurrence if the ratio of calcium
to magnesium was low and remained low during treatment. "The risk of
colorectal cancer adenoma recurrence was reduced by 32 percent among those
with baseline calcium to magnesium ratio below the median in comparison to
no reduction for those above the median"
-
Grape
seed extract induces cell cycle arrest and apoptosis in human colon
carcinoma cells - Nutr Cancer. 2008;60 Suppl 1:2-11 -
"control colorectal cancer (CRC) ... Grape seed
extract (GSE) ... Our results show that irrespective of source, GSE strongly
inhibits LoVo, HT29, and SW480 cell growth, with a G1 arrest in LoVo and
HT29 cells but an S and/or G2/M arrest in SW480 cell cycle progression. GSE
also induced Cip/p21 levels in all 3 cell lines. Furthermore, an induction
of apoptosis was observed in all 3 cell lines by GSE. Taken together, our
findings suggest that GSE could be an effective CAM agent against CRC
possibly due to its strong growth inhibitory and apoptosis-inducing effects"
- See
OPC + 95 products at iHerb
.
-
Vitamin
D and Prevention of Colorectal Adenoma: A Meta-analysis - Cancer
Epidemiol Biomarkers Prev. 2008 Nov;17(11):2958-69 -
"Circulating 25(OH)D was inversely associated with risk of colorectal
adenomas: the OR was 0.70 [95% confidence interval (95% CI), 0.56-0.87] for
high versus low circulating 25(OH)D. The highest quintile of vitamin D
intake was associated with an 11% marginally decreased risk of colorectal
adenomas compared with low vitamin D intake (OR, 0.89; 95% CI, 0.78-1.02).
For recurrent adenomas, there was a decreased risk of 12% (95% CI,
0.72-1.07) among individuals with high versus low vitamin D intake. The
inverse associations appeared stronger for advanced adenoma [OR, 0.64; 95%
CI, 0.45-0.90 for serum 25(OH)D and OR, 0.77; 95% CI, 0.63-0.95 for vitamin
D intake], but the number of studies was small" - See
vitamin D products at iHerb
.
-
Green
tea extracts for the prevention of metachronous colorectal adenomas: a pilot
study - Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3020-5 -
"The incidence of metachronous adenomas at the
end-point colonoscopy was 31% (20 of 65) in the control group and 15% (9 of
60) in the GTE group (relative risk, 0.49; 95% confidence interval,
0.24-0.99; P < 0.05). The size of relapsed adenomas was also smaller in the
GTE group than in the control group (P < 0.001). No serious adverse events
occurred in the GTE group. CONCLUSION: GTE is an effective supplement for
the chemoprevention of metachronous colorectal adenomas" - See
Jarrow green tea at iHerb
.
-
Chemotherapy is linked to severe vitamin D deficiency in patients with
colorectal cancer - Int J Colorectal Dis. 2008 Oct 2 -
"Chemotherapy is associated with a significant
increase in the risk of severe vitamin D deficiency. Patients with
colorectal cancer, especially those receiving chemotherapy, should be
considered for aggressive vitamin D replacement strategies" - See
vitamin D products at iHerb
.
-
Can Fruits, Vegetables Cut Colon Cancer Risk? - WebMD, 9/11/08 -
"Based on those answers, the researchers concluded
that men who ate the most fruits and vegetables were 26% less likely to
develop colorectal cancer than men who ate the least ... No decrease in risk
associated with fruit and vegetable consumption was seen for women"
-
New
Evidence On Folic Acid In Diet And Colon Cancer - Science Daily, 9/1/08
- "folate depletion caused increased DNA damage and
a cascade of other biological changes linked to an increased cancer risk"
- See
folic acid products at iHerb
.
-
Vitamin D Levels Tied to Colorectal Cancer Survival - Medscape, 7/14/08
- "Compared with patients with the lowest levels,
those with the highest had an adjusted hazard ratio of 0.52 for overall
mortality" - See
vitamin D products at iHerb
.
-
Vitamin D May Up Colon Cancer Survival - WebMD, 6/18/08 -
"patients with colon cancer
who were among the top 25% in levels of vitamin D
before being diagnosed were less likely to die during the study period than
those who were among the 25% with the lowest levels of the vitamin" -
[Science
Daily] - See
2,500 IU on vitamin D at iHerb

-
Glycemic index, glycemic load, and cancer risk: a meta-analysis - Am J
Clin Nutr. 2008 Jun;87(6):1793-801 - "Overall, both
GL and GI were significantly associated with a greater risk of colorectal
(summary RR = 1.26; 95% CI: 1.11, 1.44 and RR = 1.18; 95% CI: 1.05, 1.34,
respectively) and endometrial (RR = 1.36; 95% CI: 1.14, 1.62 and RR = 1.22;
95% CI: 1.01, 1.49) cancer than of breast and pancreatic cancer"
-
Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer?
Results from Model-Based Predictions - Cancer Epidemiol Biomarkers Prev.
2008 Jun 6 - "Changes in colorectal cancer risk in
response to folic acid supplementation are likely a complex function of
treatment start, duration, and effect on cell proliferation and mutations
rates. Predicted colorectal cancer incidence rates under supplementation are
mostly higher than rates without folic acid supplementation unless
supplementation is initiated early in life (before age 20 years). To the
extent to which this model predicts reality, it indicates that the effect on
cancer risk when starting folic acid supplementation late in life is small,
yet mostly detrimental"
-
Resveratrol Induces Apoptosis through ROS-Dependent Mitochondria Pathway in
HT-29 Human Colorectal Carcinoma Cells - J Agric Food Chem. 2008 Jun 4 -
"Results of the present study provide evidence
demonstrating the antitumor effect of trans-resveratrol via a ROS-dependent
apoptosis pathway in colorectal carcinoma" - See
Jarrow Resveratrol 100 at iHerb
.
-
Effects of aqueous green tea extract on activities of DNA turn-over enzymes
in cancerous and non-cancerous human gastric and colon tissues - Altern
Ther Health Med. 2008 May-Jun;14(3):30-3 - "Our data
suggest that green tea may support the medical treatment of stomach and
colon cancer" - See
Jarrow green tea at iHerb
.
-
Omega-3 linked to lower colorectal cancer risk - Nutra USA, 5/16/08 -
"In terms of fish intake, the highest average intake
was associated with a 40 per cent reduction in the risk of colorectal
cancer. In addition, this link was relevant for both colon and rectal
cancers" - See
Mega Twin EPA at iHerb
.
-
A
22-year Prospective Study of Fish, n-3 Fatty Acid Intake, and Colorectal
Cancer Risk in Men - Cancer Epidemiol Biomarkers Prev. 2008
May;17(5):1136-43 - "Fish intake was inversely
associated with colorectal cancer risk [multivariate relative risk (95%
confidence interval) for highest versus lowest category, 0.60 (0.40-0.91);
P(trend) = 0.01]. The inverse association was observed for both colon and
rectal cancers. Our findings for n-3 fatty acids were similar to those for
fish; the multivariate relative risk (95% confidence interval) of total
colorectal cancer for the highest versus lowest quartile of n-3 fatty acids
was 0.74 (0.57-0.95; P(trend) = 0.01) ... Our results from this long-term
prospective study suggest that intakes of fish and long-chain n-3 fatty
acids from fish may decrease the risk for colorectal cancer" - See
Mega Twin EPA at iHerb
.
-
Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition
on clinical outcomes and immunomodulations in colorectal cancer patients
- World J Gastroenterol. 2008 Apr 21;14(15):2434-2439 -
"Patients in the FO group trended to need a shorter
postoperative hospital stay (17.45 +/- 4.80 d vs 19.62 +/- 5.59 d, P = 0.19)
... Postoperative supplementation of omega-3 fatty acids may have a
favorable effect on the outcomes in colorectal cancer patients undergoing
radical resection by lowering the magnitude of inflammatory responses and
modulating the immune response" - See
Mega Twin EPA at iHerb
.
-
Vitamin D And Calcium Influence Cell Death In The Colon, Researchers Find
- Science Daily, 4/13/08 - "We were pleased that the
effects of calcium and vitamin D were visible enough in this small study to
be significant and reportable"
-
Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial
- Cancer Causes Control. 2008 Mar 6 - "Low dietary
folate intake has been associated with colorectal cancer risk and adenoma
recurrence. A C/T transition at position 677 in the gene encoding
methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to
interact with folate intake to modulate colorectal adenoma recurrence or
cancer risk ... In general, no statistically significant associations were
found between quartile of folate intake (dietary or total) and adenoma
recurrence ... No significant interaction was noted for total folate and
MTHFR genotype, though an increased risk of recurrence noted for the MTHFR
CT genotype was statistically significant only for those individuals with
below median intake of total folate"
-
Aspirin Associated With Reduced Colorectal Cancer Risk in Men -
Medscape, 2/12/08 - "men who reported regular
aspirin use (at least 2 times per week) had a
significantly lower risk of colorectal cancer compared with those who were
not regular aspirin users (multivariate RR, 0.79) ... However, men reporting
6 to 14 standard aspirin tablets per week had a multivariate RR of 0.72, and
those consuming more than 14 tablets per week experienced a multivariate RR
of 0.30" - Note: A RR of 0.79 is a 21% reduction, a RR of 0.30 is a
70% reduction.
-
Vitamin D Appears
to Cut Breast and Colorectal Cancer Risk - Medscape, 2/12/08 -
"Compared with a serum 25-hydroxyvitamin D level
less than 12 ng/mL, a level of at least 33 ng/mL or more was associated with
a 50% reduction in the risk for incident colorectal cancer ... vitamin D
intake of 1000 to 2000 IU per day would confer an appropriate balance
between protection against colorectal cancer and adverse events related to
hypervitaminosis" - See
vitamin D products at iHerb
.
-
Regular, Long-Term Aspirin Use Reduces Risk of Colorectal Cancer -
Doctor's Guide, 1/23/08 - "the benefit of aspirin
was not apparent until after more than five years of use. The greatest
reduction in risk was observed at cumulative doses of more than 14 standard
tablets (325 mg) per week, which is higher than normally recommended. The
benefit of aspirin use appears to diminish less than four years after
stopping use and is not evident after four to five years of discontinued
use"
-
Recreational Physical Activity and Cancer Risk in Subsites of the Colon (the
Nord-Trondelag Health Study) - Cancer Epidemiol Biomarkers Prev. 2008
Jan;17(1):183-8 - "Overall, we found an inverse
association between recreational physical activity and colon cancer risk,
but subsite analyses showed that the association was confined to cancer in
the transverse and sigmoid colon. The adjusted HR, comparing people who
reported high versus no physical activity, was 0.44 (95% CI, 0.25-0.78) for
cancer in the transverse colon and 0.48 (95% CI, 0.31-0.75) for cancer in
the sigmoid colon. The corresponding HR for cancer mortality was 0.33 (95%
CI, 0.14-0.76) for the transverse colon and 0.29 (95% CI, 0.15-0.56) for the
sigmoid colon. For rectal cancer, there was no association with physical
activity in these data"
-
Vitamin B6 may slash colorectal cancer risk - Nutra USA, 1/17/08 -
"High vitamin B6 intakes were reported to reduce the
risk of colorectal cancer by 19 per cent. The protective effect was found to
be higher among 55-year-old individuals (1,001 cases compared to 1,010
controls)" - [Abstract]
-
Dietary vitamin b6 intake and the risk of colorectal cancer - Cancer
Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82 -
"Moderately strong inverse and dose-dependent associations in the whole
sample were found between CRC risk and the intake of dietary and total
vitamin B6 in all three models [model III: odds ratio (OR), 0.77; 95%
confidence interval (95% CI), 0.61-0.98; P for trend = 0.03; OR, 0.86; 95%
CI, 0.69-1.07; P for trend = 0.12]. In addition, meta-analyses of published
studies showed inverse associations between vitamin B6 and CRC (combined
relative risk, 0.81; 95% CI, 0.68-0.96; test for overall effect P = 0.01;
combined odds ratio, 0.67; 95% CI, 0.60-0.75; test for overall effect P <
0.00001)"
-
Childhood Dairy Intake Linked to Colon Cancer - oncologystat.com,
12/19/07 - "Those who reported high levels of dairy
during childhood were about 3 times more likely to develop colon cancer than
those with low intake. A high intake was considered 2 or more cups a day,
with a low intake being half a cup or less"
-
Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr
cohort - Am J Clin Nutr. 2007 Dec;86(6):1722-9 -
"High childhood total dairy intake was associated with a near-tripling in
the odds of colorectal cancer [multivariate odds ratio: 2.90 (95% CI: 1.26,
6.65); 2-sided P for trend = 0.005] compared with low intake, independent of
meat, fruit, and vegetable intakes and socioeconomic indicators"
-
Elevated Insulin, Glucose Raise Risk of Polyp Recurrence - Medscape,
12/10/07 - "patients with elevated insulin or
glucose at the time of adenoma removal are at increased risk for recurrent
adenoma ... Levels of glucose that produced the increased risk in this study
were actually not very high, 99 mg/dL, which is right at the border of what
we would describe as impaired fasting glucose ... the odds ratio for a
recurrent polyp with advanced histology or large size was 2.43 at a fasting
glucose level above 99 mg/dL ... These results "fit with the theory that
insulin resistance, hyperinsulinemia, and hyperglycemia promote the
development of colorectal neoplasia,""
-
Chemoprevention, Naturally: Findings On Plant-derived Cancer Medicines -
Science Daily, 12/6/07 - "rats fed a diet containing
Polyphenon E, a standardized green tea polyphenol preparation, are less than
half as likely to develop colon cancer ... After 34 weeks, rats that
received Polyphenon E developed 55 percent fewer tumors compared to the
control rats that did not receive Polyphenon E. Moreover, the tumors were 45
percent smaller in rats treated with green tea extract" - See
Jarrow green tea at iHerb
.
-
Aspirin and Folic Acid for the Prevention of Recurrent Colorectal Adenomas
- Gastroenterology. 2007 Oct 10 - "In total, 99
(22.8%) of 434 patients receiving aspirin had a recurrent adenoma compared
with 121 (28.9%) of 419 patients receiving placebo (relative risk, 0.79"
-
Grape Powder Blocks Genes Linked To Colon Cancer - Science Daily,
11/14/07 - "The Wnt pathway has been linked to more
than 85 percent of sporadic colon cancers, which is the most common form of
colon cancer ... Wnt signaling in the patients taking 80 grams of grape
powder was significantly reduced ... Eighty grams of grape powder equal a
half glass of wine or 1 pound of grapes, which is equivalent to three
dietary servings of grapes, according to the USDA"
-
Riboflavin boosts folate's colorectal cancer protection - study - Nutra
USA, 10/29/07
-
Mesalamine, Folic Acid Each Cut Colorectal Cancer in Patients With
Inflammatory Bowel Disease - oncologystat.com, 10/24/07 -
"Patients who took at least 1 mg of folic acid daily
also had about a 90% cut in their CRC incidence during follow-up, compared
with the controls" - See
iHerb
folic acid products.
-
Omega-3 to cut colon cancer: meta-analysis - Nutra USA, 10/25/07 -
"the highest consumption of fish oil was associated
with 12 per cent reduction in the incidence of colorectal cancer" - [Abstract]
- See Mega Twin EPA at
iHerb
.
-
Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and
induces apoptosis in a colon cancer cell line - Cancer Lett. 2007 Oct 6
- "grape seed proanthocyanidin extract (GSPE) ...
GSPE (10-100mug/ml) significantly inhibited cell viability and increased
apoptosis in CaCo2 cells, but did not alter viability in the normal colon
cell line (NCM460). The increased apoptosis observed in GSPE-treated CaCo2
cells correlated with an attenuation of PI3-kinase (p110 and p85 subunits)
and decreased PKB Ser(473) phosphorylation. GSPE might thus exert its
beneficial effects by means of increased apoptosis and suppression of the
important PI3-kinase survival-related pathway" - See
grape seed products at iHerb
.
-
Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating
growth inhibition of colon cancer cells by modulating EGFR and IGF-1R -
Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to
the conventional chemotherapeutic agent(s)/regimen could be an effective
therapeutic strategy for colorectal cancer" - See
curcumin/turmeric products at iHerb
.
-
Fruits, Veggies Don’t Cut Colon Cancer - WebMD, 9/25/07 -
"Overall, a higher intake of fruits and vegetables
does not strongly reduce your risk of colon cancer"
-
CLA isomers show promise against colon cancer - study - Nutra USA,
9/24/07 - "We have demonstrated that diets
containing 0.1 per cent c9,t11 and t10,c12 CLA were
equally effective in inhibiting colon cancer cell metastasis in vivo"
- See
CLA products at iHerb
.
-
Influence of conjugated linoleic acid isomers on the metastasis of colon
cancer cells in vitro and in vivo - J Nutr Biochem. 2007
Oct;18(10):650-7 - "diets containing 0.1% c9,t11 and
t10,c12 CLA were equally effective in inhibiting colon cancer cell
metastasis in vivo. However, in vitro, only c9,t11 but not t10,c12 inhibited
colon cancer cell migration and MMP-9 activity" - See
CLA products at iHerb
.
-
Vitamin D for Cancer Prevention? - WebMD, 9/5/07 -
"The 2,000-IU daily dose of vitamin D suggested by
the reviewers is currently considered the "tolerable upper limit" for
vitamin D ... a projected 50% reduction in colon cancer incidence would
require a universal intake of 2,000 IU per day of vitamin D3 ... A similar
reduction in breast cancer incidence would require 3,500 IU per day"
-
Study Shines More Light On Benefit Of Vitamin D In Fighting Cancer -
Science Daily, 8/21/07 - "For the first time, we are
saying that 600,000 cases of breast and colorectal cancer could be prevented
each year worldwide, including nearly 150,000 in the United States alone ...
The serum level recommended by the study would correspond to intake of 2000
International Units per day of vitamin D3 for a meaningful reduction in
colorectal cancer" - See
vitamin D products at iHerb
.
-
Colon Cancer on curcumin and Vectibix - Johns Hopkins, 8/14/07 -
"University of Texas researchers treated some human
colorectal cancer cells with neurotensin, with and without curcumin. They
confirmed that neurotensin started a chain reaction of chemicals that can
increase the growth of cancer and also the migration of cancer cells and
that curcumin blocked the process ... Curcumin appears to do this by
blocking the biochemical signals sent by neurotensin that contribute to
colon cancer cell growth and migration (the spread of cancer to other body
sites)" - See
curcumin/turmeric products at iHerb
.
-
Inhibition Of Tumorigenesis in Apc(Min/+) Mice by a Combination of
(-)-Epigallocatechin-3-gallate and Fish Oil - J Agric Food Chem. 2007
Aug 16 - "The effect of a combination of
(-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal
tumorigenesis in Apc (Min/+) mice fed a high-fat diet was investigated in
the present study. The combined treatment of EGCG and fish oil for 9 weeks
reduced the tumor number by 53% as compared to controls while neither agent
alone had a significant effect. Apoptosis was significantly increased in all
treatment groups" - See Mega Twin EPA at
iHerb
and
Jarrow green tea at iHerb .
-
Compounds That Color Fruits And Veggies May Protect Against Colon Cancer
- Science Daily, 8/19/07 - "In animal studies, rats
induced with colon cancer cells were fed a daily diet of anthocyanin
extracts either from bilberries and chokeberries, which are most often used
as flavorings or to make jams and juices. The dietary addition of the
anthocyanin extracts reduced signs of colon tumors by 70 and 60 percent,
respectively, when compared to control rats"
-
Green tea may stop colon cancer in its tracks - study - Nutra USA,
8/9/07 - "At the age of eight weeks, the mice were
divided into two groups - one to receive water or a green tea solution (0.6
per cent) as the only beverage source for a further four to eight weeks ...
consumption of the green tea solution significantly inhibited the formation
of new tumours in the colon" - See
Jarrow green tea at iHerb
.
-
Green tea selectively targets initial stages of intestinal carcinogenesis in
the AOM-ApcMin mouse model - Carcinogenesis. 2007 Jul 17 -
"green tea specifically targets initial stages of
colon carcinogenesis; the time of administration of green tea is pivotal for
effective chemoprevention. Beverage levels of GT are not likely to inhibit
the progress of any large adenomas or adenocarcinomas existing prior to the
tea administration"
-
A Nested Case-Control Study of Plasma 25-Hydroxyvitamin D Concentrations and
Risk of Colorectal Cancer - J Natl Cancer Inst. 2007 Jul 10 -
"Our data provide additional support for the inverse
association between vitamin D and colorectal and, in particular, colon
cancer risk"
-
Mistletoe in Supportive Care for Colorectal and Pancreatic Cancers -
Doctor's Guide, 7/12/07 - "Use of a fermented
mistletoe extract (MEx; Iscador®) in long-term
supportive care in hospitals and private practices demonstrated significant
survival benefit and improvements in quality of life for patients with
surgically treated primary, nonmetastatic colorectal carcinoma and for
patients with all-stages pancreatic carcinoma, when combined with adjuvant
chemotherapy and/or radiotherapy or passive aftercare in two multicentre,
controlled, retrospective, epidemiological, observational, cohort studies"
-
A Nested Case-Control Study of Plasma 25-Hydroxyvitamin D Concentrations and
Risk of Colorectal Cancer - J Natl Cancer Inst. 2007 Jul 10 -
"we observed a non-statistically significant inverse
association between higher plasma 25(OH)D concentration and risk of
colorectal cancer and a statistically significant inverse association for
colon cancer (highest versus lowest quintile: odds ratio [OR] = 0.46, 95%
confidence interval [CI] = 0.24 to 0.89; P(trend) = .005). After pooling the
results from the HPFS and NHS, higher plasma 25(OH)D concentrations were
statistically significantly associated with decreased risks of both
colorectal cancer (highest versus lowest quintile, OR = 0.66, 95% CI = 0.42
to 1.05; P(trend) = .01) and colon cancer (highest versus lowest quintile,
OR = 0.54" - See
vitamin D products at iHerb
.
-
Different omega-3 may offer different colorectal protection - Nutra USA,
7/11/07 - "Increased intake of EPA was associated
with a 41 per cent reduction in risk, while DHA was associated with a 37 per
cent reduction in risk, comparing highest against lowest average intakes"
- [Abstract]
- See Mega Twin EPA at
iHerb
.
-
Dietary Fatty acids and colorectal cancer: a case-control study - Am J
Epidemiol. 2007 Jul 15;166(2):181-95 - "Significant
dose-dependent reductions in risk were associated with increased consumption
of omega-3 polyunsaturated fatty acids (highest vs. lowest quartile of
intake: odds ratio = 0.63, 95% confidence interval: 0.50, 0.80; p < 0.0005
for trend) and of eicosapentaenoic (odds ratio = 0.59, 95% confidence
interval: 0.47, 0.75; p < 0.0005 for trend) and docosahexaenoic (odds ratio
= 0.63" - See Mega Twin EPA at
iHerb
.
-
Vitamin D Fights Colon Cancer - WebMD, 7/10/07 -
"The findings support a number of previous studies that link vitamin D to
colon cancer protection, to protection against breast and ovarian cancer, to
protection against pancreatic cancer, and to overall reduction of cancer
risk" - See
vitamin D products at iHerb
.
-
Low Intake of Vitamin B-6 Is Associated with Increased Risk of Colorectal
Cancer in Japanese Men - J Nutr. 2007 Jul;137(7):1808-1814 -
"We observed a significant inverse association
between vitamin B-6 intake and colorectal cancer in men. Compared with the
lowest quartile, the multivariate hazard ratio (95% [CI]) in the highest
quartile of intake was 0.69"
-
Dietary fiber and colorectal cancer risk: the multiethnic cohort study -
Cancer Causes Control. 2007 Jun 8 - "Dietary fiber was inversely associated with colorectal cancer risk in men,
but its relation to replacement hormone use and other factors affected its
inverse association in women"
-
Prospective cohort study of green tea consumption and colorectal cancer risk
in women - Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1219-23 -
"The multivariate relative risk of
CRC was 0.63 (95% confidence interval, 0.45-0.88) for women who reported
drinking green tea regularly at baseline compared with nonregular tea
drinkers" - I read that as a 37% reduction in risk. See
Jarrow green tea at iHerb
.
- Ben
-
Diet
May Influence Survival After Treatment For Stage III Colon Cancer, Study
Suggests - Science Daily, 6/4/07
-
Life
Long Vegetarian Diet Reduces The Risk Of Colorectal Cancer - Science
Daily, 5/22/07 - "a vegetarian diet
is associated with reduced risk of CRC if started very early in life"
-
Aspirin May Stop Colon Cancer - WebMD, 5/10/07 -
"people who took a full-dose aspirin
tablet every day for at least five years had as much as a 74% lower risk of
colon cancer 10 to 14 years later. In the U.S."
-
Curcumin for chemoprevention of colon cancer - Cancer Lett. 2007 Apr 18
- "Overwhelming in vitro evidence
and completed clinical trials suggests that
curcumin may prove to be useful for the chemoprevention of colon cancer
in humans" - See
curcumin/turmeric products at iHerb
.
-
Coffee consumption and risk of colorectal cancer in a population-based
prospective cohort of Japanese men and women - Int J Cancer. 2007 Apr 20
- "We observed a significant inverse
association between coffee consumption and the risk of developing invasive
colon cancer among women. Compared with those who almost never consumed
coffee, women who regularly consumed 3 or more cups of coffee per day had a
RR of 0.44 ... In men, no significant decrease was observed in any
colorectal cancer site"
-
Berries May Help Prevent Cancer - WebMD, 3/26/07
-
Blueberries tackle bowel cancer - BBC News, 3/26/07 -
"The key ingredient, pterostilbene,
is a natural antioxidant and mops up highly reactive molecules called free
radicals that can trigger cancer growth ... Rats given a cancer-causing
agent but then fed pterostilbene had far fewer pre-cancers in their bowels
than other rats ... The blueberry compound also reduced inflammation and the
rate of cell division in the bowel"
-
Fruit May Sway Colon Cancer Risk - WebMD, 3/20/07 -
"The group that had the lowest risk of
having an adenoma was the group that ate a lot of fruit and avoided meat,
basically"
-
Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study
- Br J Cancer. 2007 Feb 12;96(3):510-3 -
"Statistically significant inverse
trends in risk were observed in overweight subjects for colon and proximal
colon cancer across increasing quintiles of magnesium uptake"
-
Vitamin D Backed For Cancer Prevention In Two New Studies - Science
Daily, 2/8/07 -
"Two new vitamin D studies using a
sophisticated form of analysis called meta-analysis, in which data from
multiple reports is combined, have revealed new prescriptions for possibly
preventing up to half of the cases of breast cancer and two-thirds of the
cases of colorectal cancer in the United States ... The serum level
associated with a 50 percent reduction in risk could be maintained by taking
2,000 international units of vitamin D3 daily plus, when the weather
permits, spending 10 to 15 minutes a day in the sun" - See
Vitamin D products at iHerb
.
-
Prolonged effect of calcium supplementation on risk of colorectal adenomas
in a randomized trial - J Natl Cancer Inst. 2007 Jan 17;99(2):129-36 -
"placebo or 1200 mg of elemental
calcium daily for 4 years ... During the first 5 years after randomized
treatment ended, subjects in the calcium group still had a substantially and
statistically significantly lower risk of any adenoma than those in the
placebo group (31.5% versus 43.2%"
-
Calcium May Reduce Colon Cancer Risk - WebMD, 1/16/07 -
"Patients with a history of nonmalignant
polyps took either 1,200 milligrams of calcium in supplement form or a
placebo daily for four years ... Calcium use was associated with a 17% lower
relative risk for polyp recurrence"
-
Colorectal cancer protective effects and the dietary micronutrients folate,
methionine, vitamins b6, B12, C, e, selenium, and lycopene - Nutr
Cancer. 2006;56(1):11-21 - "a diet
containing the dietary micronutrients involved in DNA methylation (folate,
methionine, and vitamins B6 and B12) and some of those with antioxidant
properties (selenium and vitamins E and C) may have a role to play in
lowering colorectal cancer risk and also that such protection can be
achieved by dietary means alone"
-
More support omega-3 may protect against colorectal cancer - Nutra USA,
11/22/06 - "A diet rich in omega-3
polyunsaturated fatty acids (PUFAs) could reduce the risk of colorectal
cancer by 85 per cent"
-
Low
Folate Diets Found To Increase Risk Of Colorectal Cancer - Science
Daily, 11/14/06 - "None of the mice
fed a control diet developed tumours whereas 1 in 4 mice on the
folate-deficient diet developed at least one tumour"
-
Soy, Fish May Cut
Cancer Risk - WebMD, 11/14/06 - "men who ate the most fish -- and that was five or more servings per week of
fish -- compared to the least fish -- less than one time per week -- had a
40% lower risk of developing colorectal cancer"
-
Calcium again linked to lower colorectal cancer risk - Nutra USA,
11/8/06 - "the relative risk of
colorectal cancer for the highest calcium intake group was 40 per cent lower
compared to the lowest intake group"
-
Grape Seed Extract Halts Cell Cycle, Checking Growth Of Colorectal Tumors In
Mice - Science Daily, 10/29/06 - "documented a 44 percent reduction of advanced colorectal tumors in the
animals, and also revealed, for the first time, the molecular mechanism by
which grape seed extract works to inhibit cancer growth" - See
iHerb
or
Vitacost
grape seed extracts.
-
Red Wine vs. Colon
Cancer - WebMD, 10/24/06 - "3%
of red wine drinkers had such abnormal growths, compared with nearly 9% of
white wine drinkers and almost 10% of teetotalers ... they suggest that a
compound found in grapes and red wine – the antioxidant resveratrol -- may
cut the odds of getting abnormal colon growths that can become cancerous"
-
Resveratrol in red wine could cut colorectal cancer risk - Nutra USA,
10/23/06 - "Drinking more than three
glasses of red wine a week could cut the risk of colorectal cancer by almost
70 per cent ... the active component in wine that may be behind the apparent
benefits is most likely resveratrol"
-
Grape Seed Extract
vs. Colon Cancer - WebMD, 10/19/06 -
"The cancer cells treated with grape
seed extract were more likely to halt their normal growth cycle and die,
compared to those not treated with the extract"
-
Flavonoids linked to colorectal cancer protection - Nutra USA, 8/9/06 -
"A diet rich in certain flavonoids,
from eating plenty of fruit and vegetables, could reduce the risk of
colorectal cancer by over 40 per cent, says a large observational study from
Italy"
-
Chemical in Curry
May Cut Colon Cancer - WebMD, 8/2/06 -
"Each of the patients then received
480 milligrams of curcumin and 20 milligrams of quercetin three times a day
for six months ... The results showed that treatment with the curry and
onion compounds reduced the average number of polyps by 60%, and decreased
their size by 50%" - See
iHerb
or
Vitacost
curcumin products and
iHerb
or
Vitacost
quercetin products.
-
Moderate
Exercise Improves Survival Rates For Colon Cancer Survivors - Science Daily,
7/14/06
-
Vitamin B6 May Help Prevent Colorectal Cancer - Medscape, 6/10/06 -
"There was an inverse association
between vitamin B6 intake and colorectal cancer, with the relative risk (RR) for
the highest quintile vs the lowest quintile being 0.66 ... Vitamin B6 may have a
role in colorectal cancer prevention through reduction of oxidative stress and
synthesis of a form of folate required for DNA repair, synthesis, and
methylation"
-
Moderate Alcohol Consumption Protects Against Colorectal
Adenoma - Doctor's Guide, 5/24/06 -
"Non-drinkers had a 40% higher risk of adenoma than those in the moderate (1-2
drinks and 2-6 drinks per week) groups. Those drinking 7 or more alcoholic
beverages per week had 150% higher risk of adenoma than the moderate groups"
- Lowering
Colon Cancer Risk? - Dr. Weil, 5/2/06
-
More support that dairy could reduce colorectal cancer risk - Nutra USA,
3/8/06 - "A diet rich in dairy
products could cut the risk of colorectal cancer by half, an effect that is
not due solely to calcium"
-
More support for magnesium against colon cancer - Nutra USA, 1/31/06 -
"The hazard ratio, a measure of the
risk, was statistically 25 per cent lower for the volunteers with the
highest intake of magnesium (more than 356 mg per day)"
-
Epidemiology of
Vitamin D and Colorectal Cancer: Recent Findings - Medscape, 1/9/06 -
"In vitro, animal and clinical
studies strongly indicate that vitamin D may have anticancer benefits,
including against progression (such as metastasis) in colorectal cancer and
possibly other cancers. Thus improving vitamin D status could be potentially
beneficial against either incidence or mortality, or both ... Current
recommended intakes of vitamin D (for example, 400 IU/day) may be too low to
provide maximal benefits, though the precise optimal dose remains unestablished"
-
High-fat dairy food and conjugated linoleic acid intakes in relation to
colorectal cancer incidence in the Swedish Mammography Cohort - Am J
Clin Nutr. 2005 Oct;82(4):894-900 -
"For CLA, the multivariate rate ratio of colorectal
cancer in a comparison of the 2 extreme quartiles of intake was 0.71 ...
These prospective data suggest that high intakes of high-fat dairy foods and
CLA may reduce the risk of colorectal cancer" - [Food
Navigator]
-
Selenium supplementation and colorectal adenomas: An analysis of the
nutritional prevention of cancer trial - Int J Cancer. 2005 Oct 10 -
"In addition to being associated
with a reduced risk of incident CRC [colorectal cancers], selenium
supplementation was associated with a significantly reduced risk of
prevalent adenomas, but only among subjects with either a low baseline
selenium level or among current smokers" - See
iHerb
or
Vitacost
selenium products.
-
High-Dose Aspirin Prevents Colon Cancer - WebMD, 8/23/05
-
Long-Term, Regular Aspirin Use Associated With Significant Reduction in
Colorectal Cancer Risk Among Women - Doctor's Guide, 8/23/05 -
"Among women who regularly used
aspirin (2 or more standard [325-mg] tablets per week), there was a 23%
reduced relative risk for colorectal cancer compared with nonregular users.
However, significant risk reduction was not observed until more than 10
years of use"
-
Calcium Supplements May Help Prevent Polyps
- WebMD, 7/19/05 -
"people who took
calcium had about a 25% lower risk of developing polyps in their colon"
-
Fish may protect against colorectal cancer
- Nutra USA, 6/15/05 -
"People eating less
than 14g of fish a day were 40 per cent more likely to develop the cancer
than those eating more than 50g per day"
-
Vitamin B6 May Help Prevent Colorectal Cancer
- Medscape, 6/10/05 -
"those in the highest
quintile had a 34% lower risk of colorectal cancer (multivariate rate ratio"
-
High vitamin B intake cuts risk of colorectal cancer
- Nutra USA, 6/6/05
- Preventing
Colon Cancer? - Dr. Weil, 5/26/05
-
Moderate Exercise Reduces Risk of Colon Cancer Recurrence
- Doctor's Guide, 5/20/05 - "disease-free survival was 49% lower in patients who engaged
in 18 to 27 MET-hours/week of physical activity, compared with those who
exercised less than 3 MET-hours/week. "This is equivalent to a 2 to 3 mph
walk a day, 6 days a week, running fast 2 times a week or playing tennis 3 a
week,""
-
Aspirin May Prevent Colon Cancer Recurrence
- Doctor's Guide, 5/20/05 -
"Recurrence-free
survival was 55% lower in aspirin users than non-users (95% CI, 0.21-0.96),
disease-free-survival was 54% lower (95% CI 0.23-0.95), and overall survival
was 51% lower"
-
Exercise May Cut Risk of Colon Cancer's Return
- WebMD, 5/17/05
-
Aspirin, COX-2 Inhibitors Effective as Adjuvant Therapy in
Stage III Colon
- Medscape, 5/16/05 - "The chemotherapy provides about 35% improvement in survival
compared with surgery alone for that stage of colon cancer, Dr. Fuchs said
in an interview. In comparison, aspirin or the two cyclooxygenase 2 (COX-2)
inhibitors produced a reduction in risk of recurrence and death that was
about 50% beyond what was achieved by chemotherapy after surgery"
-
Aspirin Prevents Colon Cancer Return - WebMD,
5/16/05
-
Vitamin B-6 May Help People Avoid Colon Cancer
- WebMD, 5/3/05 -
"The risk of
colorectal cancer was 44% lower for the women with the highest blood level
of vitamin B-6 compared with women with the lowest level of vitamin B-6"
-
Calcium Supplements Keep on Working Even After They Are
Stopped - Doctor's Guide, 4/21/05 - "People at high risk of colon cancer appear to reduce the
risk of developing polyps while taking calcium supplements and continue to
benefit for as long as 5 years after they stop taking them"
-
Statins Lower Prostate Cancer Risk
- WebMD, 4/18/05 -
"long-term use of
calcium supplements protects against the development of potentially
precancerous colon polyps for years after you stop taking them"
- Calcium May Help Prevent Colorectal Cancer -
WebMD, 1/28/05
-
Magnesium intake in relation to risk of colorectal cancer in
women - JAMA. 2005 Jan 5;293(1):86-9 -
"a high magnesium intake may reduce the occurrence of
colorectal cancer in women"
-
Selenium May Lower Colon Cancer Risk
- WebMD, 11/16/04 -
"participants
with the highest blood levels of selenium were
34% less likely to develop a new adenoma compared with those with the lowest
selenium blood levels"
-
Milk, Calcium, May Cut Colon Cancer Risk
- WebMD, 7/6/04
-
Calcium More Protective Against Some Polyps
- WebMD, 6/15/04 -
"The calcium
group had 18% fewer noncancerous polyps and 35% fewer advanced polyps ...
compared with the placebo group ... her study suggests that total calcium
intake over 1,200 mg daily is necessary for colon protection -- and that a
high-fiber diet with modest levels of fat will boost the protective effects"
-
New findings on soy and cancer prevention
- Nutra USA, 5/13/04
-
Folate and colorectal neoplasia: relation between plasma and
dietary markers of folate and adenoma recurrence -
Am J Clin Nutr. 2004 Apr;79(4):691-697 -
"A lower recurrence of
colorectal adenomas was shown in subjects with higher intakes and plasma
concentrations of folate. Additional markers involved in folate metabolism,
including lower homocysteine and higher vitamin B-6 intake, were also
associated with lower odds of recurrence"
-
Heme Iron and Zinc Have Opposite Effects on Colon Cancer Risk
- Doctor's Guide, 3/29/04 -
"heme iron
appears to raise the risk of proximal colon cancer while dietary zinc
appears to lower the risk of both proximal and distal colon cancer"
-
5 a day force, new evidence - Nutra
USA, 2/11/04 -
"High intakes
of vegetables, fruits and wholegrain foods reduces the risk of rectal cancer
by 28 per cent, 27 per cent and 31 per cent, respectively ... High fiber
diet – more that 34 grammes a day reduced risk of rectal cancer by a
staggering 66 per cent"
- Aspirin Use May Prevent Colon Cancer - WebMD,
2/2/04 - "Regularly taking
aspirin -- more than two tablets a week -- reduced the risks of polyps
by 25% ... while higher doses of aspirin (325 milligrams per day) may be
necessary for optimal prevention of polyps, the risk of severe
gastrointestinal bleeding remains a serious concern" - See
Drugstore.com aspirin products
.
-
Effect of an omega-3 fatty acid containing lipid emulsion
alone and in combination with 5-fluorouracil (5-FU) on growth of the colon
cancer cell line Caco-2 - Eur J Nutr. 2003
Dec;42(6):324-31 - "FO has a potent antiproliferative effect on Caco-2 cells"
- Diet, lifestyle
may lower colon cancer risk - MSNBC, 1/23/04 -
"One prime
suspect now is insulin resistance. In this condition, higher levels of
insulin circulate because the body is less responsive to it. Insulin and
related growth factors seem to change cell processes in ways that promote
the development of cancer"
-
Lycopene, ß-carotene, and colorectal adenomas
-Am J of Clin Nutr, Vol. 78, No. 6, 1219-1224, 12/03 -
"Our findings support the hypothesis that lycopene
contributes to the protective effect of high tomato intakes against the
risk of colorectal adenomas"
- What Causes, Prevents Colon Polyps - WebMD,
12/9/03 -
"Just take an
aspirin, a multivitamin, and eat a bowl of fiber-packed cereal with some
milk ... In this new report,
vitamin D shines -- it's associated with a
one-third reduced risk of serious colon polyps that often lead to cancer in
men getting at least 645 IUs of this nutrient each day"
-
Calcium And Vitamin D Collaborate To Reduce Colorectal Cancer
Risk - Intelihealth, 12/3/03
- Calcium Intake Plus Vitamin D May Protect Against Colon Adenomas
- Medscape, 12/2/03 -
"Calcium
supplementation reduces the rate of colon adenomas, but only if
vitamin D levels are adequate"
-
Studies Associate Fish And Multivitamins With Reduced Risk
For Colorectal Cancer - Doctor's Guide, 7/16/03 -
"Only fish
consumption was associated with a reduction in risk ... Both processed meat
and red meat consumption were associated with increased risk ... Duration of
multivitamin use was associated with a decreased risk of rectal cancer"
-
An Aspirin a Day Does Not Reduce Colorectal Cancer Risk Among
Smokers - Doctor's Guide, 7/16/03
- Night Shifts May Raise Cancer Risk - WebMD, 6/3/03
- "Data from an ongoing study of
almost 80,000 nurses already suggest that working nights increases a woman's
risk of
breast cancer ... a new analysis points to a
similar association for colorectal cancer ... "The peak production of
melatonin occurs at about 1 or 2 a.m." Exposure to light at night stops
the production of melatonin" - See
iHerb
or
Vitacost
melatonin products.
- 2 Studies Contradict Earlier Research Showing No Benefit of Fiber on Colon
Cancer Risk - WebMD, 5/1/03 -
"What's more
consistent is the two newest findings, both published in the May 3 issue of
The Lancet ... those eating a high-fiber diet -- upwards of 36 grams of
fiber each day -- were 25% less likely to develop polyps than those
eating fewer than 12 grams ... The other study, conducted on 520,000 people
in 10 European countries and called the largest study ever, also initially
found a 25% reduced rate in colorectal cancer in those eating high-fiber
diets of about 35 grams daily compared with those eating less than 15 ...
the protective effect was greatest on the left side of the colon, where most
cancers originate ... Fiber is believed to help reduce risk in two ways: It
keeps you regular to remove toxins from the intestines, and bacteria living
in the gut feeds on it -- producing beneficial byproducts to keep the colon
healthy"
-
Europe-Wide Study Finds Fibre Can Cut Colorectal Cancer Risk
By Up To 40% - Doctor's Guide, 5/1/03 -
"People
consuming an average of 35 g
fibre a day can cut their risk of colorectal
cancer up to 40%, compared to people who consume an average of 15 g per day
... Protection was greatest for the left side of the colon, and least for
the rectum ... foods supplying fibre also contribute many other nutrients
and phytochemicals that have been linked to cancer protection, and which
could account for the protective effects seen"
-
Latest Evidence Links High-Fibre Diet With Reduced Colon
Cancer Risk - Doctor's Guide, 5/1/03
- Selenium Reduces Risk of Some Cancers: FDA Approves Claim
- New Hope Natural Media, 4/17/03 -
"Companies that manufacture selenium
supplements will now be permitted by the United States Food and Drug
Administration (FDA) to claim that selenium supplements may reduce the risk
of some cancers, according to a statement by the FDA. Although the FDA does
not permit manufacturers to list specific types of cancer in the health
claim, studies suggest selenium supplementation may reduce the risk of
colon, prostate,
lung, liver and
esophageal cancers" - See
iHerb
and
Vitacost
selenium products.
-
Calcium, vitamin D, dairy products, and risk of colorectal
cancer in the cancer prevention study II nutrition cohort
- Cancer Causes Control 2003 Feb;14(1):1-12 -
"Total calcium intake (from diet and
supplements) was associated with marginally lower colorectal cancer risk in
men and women ... The association was strongest for calcium from supplements
... Total vitamin D intake (from diet and multivitamins) was also inversely
associated with risk of colorectal cancer, particularly among men"
- Red Meat + Fats + Pasta = Colon Cancer - WebMD,
2/10/03 -
"Women who ate
the most Western foods had 50% more colon cancers than the women who ate the
least Western foods"
-
Low Dietary Copper Increases Fecal Free Radical Production,
Fecal Water Alkaline Phosphatase Activity and Cytotoxicity in Healthy Men
- J. Nutr. 133:522-527, 2/03 -
"One possible dietary
factor that may increase susceptibility to colon cancer is inadequate
copper intake ... Low dietary copper significantly (P < 0.01) increased
fecal free radical production"
- Colon Cancer Rise Linked to Beef, Pork - WebMD,
11/15/02 -
"a high intake
of red meat -- including beef and pork -- doubled the risk of colorectal
cancer. No rise was seen for those reporting increased consumption of other
meats or seafood. Eating vegetables was associated with a reduction in risk
... People who ate lots of red meat and few vegetables were more than 2.5
times more likely to get colon cancer"
- More Good News on Tea - WebMD, 9/27/02 -
"The latest studies suggest tea might lower
cholesterol, improve
heart health, prevent
rectal cancer in women, and reduce cell damage in smokers" - See
iHerb
or
Vitacost
green tea products.
- Folic Acid Fights Colon Cancer - WebMD, 7/19/02
-
Folic Acid Supplement Reduces Cell Proliferation In High Risk
Colorectal Cancer Patients - Doctor's Guide,
7/18/02 - "Patients at high risk of
colorectal cancer could cut their risk dramatically with a daily supplement
of 2 mg of folic acid" - See
iHerb
or
Vitacost
folic acid products.
- Moderate Calorie Cutbacks Fight Cancer - WebMD,
4/24/02
-
Aspirin Lowers Colon Cancer Risk -
Intelihealth, 4/8/02 -
"A daily baby
aspirin modestly reduces the risk of colon cancer by preventing the
growth of ominous polyps ... the 80-milligram baby aspirin size taken daily
reduces this risk by 19 percent ... the researchers found that 38 percent of
those getting baby aspirin had new polyps, compared with 47 percent of
people getting placeboes. However, little benefit was seen among those
getting full-size aspirin. Their recurrence rate was 45 percent"
- Baby Aspirin Lowers Colon Cancer Risk - WebMD,
4/8/02
-
Exposure To Sunlight Lowers Risks Of Four Cancers
- Doctor's Guide, 4/4/02 -
"exposure to
sunlight contributes to non-melanoma skin cancer. "By contrast, several
ecological studies suggest that sunlight may protect against female breast,
ovarian, prostate, and colon cancer, all diseases that contribute to a
substantially higher proportion of cancer mortality in the western
industrialized world." ... Some studies have suggested an association
between circulating vitamin D in blood, which is largely derived from
sunlight, or dietary vitamin D and colorectal, prostate and female breast
cancers"
-
Calcium Intake May Be Associated With Reduced Risk Of Colon
Cancer - Intelihealth, 3/19/02 -
"Men and women
who included more than 700 to 800 mg of calcium in their diets each day had
a 40% to 50% lower risk of distal colon cancer compared with participants
taking less than 500 mg of calcium each day"
- Boning Up on Calcium Fights Colon Cancer - WebMD,
3/19/02
- Well-Rounded Prevention May Lower Colon Cancer Risk
- WebMD, 2/4/02
-
Almonds Promote Colon Health -
Nutrition Science News, 6/01
- Well-Rounded Prevention May Lower Colon Cancer Risk
- WebMD, 2/4/02 -
"Research
suggests that aspirin, nonsteroidal anti-inflammatory drugs, the vitamin
folate, and the mineral calcium, all may have a protective effect against
colon cancer. Estrogen, too, may have a protective effect ... The best way
to lower your risk of colon cancer is to reduce red meat intake, exercise
regularly, stop smoking, and control your weight ... aspirin reduced the
risk of colon cancer death by 40%, when taken 16 times per month or more.
Similarly, the nonsteroidal anti-inflammatory drug Clinoril (sulindac)
significantly reduced polyps in high-risk people. Both aspirin and Clinoril
can cause stomach bleeding, but the new nonsteroidal anti-inflammatory drug
Celebrex may prevent colon polyps without this side effect ... The herb
rosemary, the spice turmeric, the skin of red grapes, and green tea all have
similar effects as the [nonsteroidal anti-inflammatory drug] Celebrex"
-
Very Low Fruit, Vegetable Consumption Produces Highest
Colorectal Cancer Risk - Doctor's Guide, 4/6/01 -
"Sub-analysis
showed that this association was due largely to fruit consumption ... We
observed no association between colorectal cancer risk and the consumption
of cereal fiber, even at amounts substantially greater than previously
examined"
- Canceling Cancer: New Cancer Prevention Strategies on the Horizon
- WebMD, 3/26/01 -
"Huerta and
his team used a compound similar to vitamin D
but with some different properties. Sure enough, this compound, which they
call Ro 26-9114, reduced the growth of colon tumors in mice to a similar
degree as regular vitamin D but without the problematic side effects"
- Calcium Pills May Stave Off Colon Cancer - WebMD,
3/9/01 -
"among
patients who took calcium (for one year), the
size and growth of the benign tumors -- as measured by pathologists who
looked at tissue biopsies -- was reduced by 58%. In contrast, only a 26%
reduction was seen in patients who did not take calcium . . . The protective
effect of calcium was most pronounced among the patients on a low-fat diet
and taking calcium: 73% of those patients had noticeable reductions in
adenomas. In contrast, there were no differences in adenoma reductions
between high-fat eaters in the calcium and no-calcium groups"
-
Vitamin A Reduces Risk Of Colorectal Adenoma
- Doctor's Guide, 2/23/01 - "Higher
serum concentrations of vitamin A, however,
were significantly associated with a reduced risk of colorectal adenomas"
-
Colon Cancer Prevented, Promoted by Diet
- Nutrition Science News, 2/01
- Wine May Reduce the Risk of Colon Cancer, Even in Smokers
- WebMD, 10/16/00
-
Study: Fiber Doesn't Prevent Cancer
- Intelihealth, 10/13/00 -
"29 percent
of those receiving the supplement (ispaghula husk, a compound similar to
psyllium that is not part of the average diet) got at least one new tumor
within three years. That compares with 20 percent of those given fake
granules"
- Fiber May Hurt, More Than Help, in Preventing Colon Cancer
- WebMD, 10/12/00
-
Chemicals in apples slow cancer growth in lab tests,
scientists report - CNN, 8/30/00
-
Low Fat, High Fiber Doesn't Cut Colon Cancer Risk
- Nutrition Science News, 8/00
-
Can calcium prevent colon cancer? -
Nutrition Science News, 6/00
- Preventing Colon Cancer: What You Can Do - WebMD,
4/19/00
- Estrogen
Reduces Risk Of Colorectal Cancer - Doctor's
Guide, 10/28/99
- Calcium
Supplements Help Prevent Polyp Recurrence -
Doctor's Guide, 1/14/99
-
Study says calcium may cut colon cancer risk
- CNN, 9/22/98
- Vitamin E
May Enhance Effectiveness Of Colorectal Cancer Drug
- Doctor's Guide, 11/20/97
- Vitamin
Supplements May Reduce Colon Cancer Risk -
Doctor's Guide, 11/6/97
- Vitamin E
May Help Protect Against Colon Cancer - Doctor's
Guide, 11/5/97
- Scientific
Evidence On FOS Deserves Serious Attention, Nutrition Expert Says
- Doctor's Guide, 5/8/97
- Research
Highlights Positive Effects of Dietary Supplement NutraFlora FOS
- Doctor's Guide, 12/9/96
CME:
General Information:
-
Colon Cancer - American Academy of Family Physicians
- Colon Cancer - emedicine.com
-
Colon Cancer - familydoctor.org
-
Colorectal Cancer - Intelihealth
-
Colon Cancer - Veritas Medicine
- Books on colon cancer - Amazon.com
- Treatments for colon cancer
- Medifocus.com
Other News:
-
High
blood sugar levels in older women linked to colorectal cancer - Science
Daily, 11/29/11 - "The Einstein study involved women who
were enrolled in the National Institutes of Health''''s landmark Women''''s
Health Initiative study ... By the end of the 12-year period, 81 of the women
had developed colorectal cancer. The researchers found that elevated baseline
glucose levels were associated with increased colorectal cancer risk -- and that
women in the highest third of baseline glucose levels were nearly twice as
likely to have developed colorectal cancer as women in the lowest third of blood
glucose levels ... obesity''''s impact on this cancer may be due to elevated
glucose levels, or to some factor associated with elevated glucose levels"
-
Reduced Risk
of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes: A
meta-analysis - Diabetes Care. 2011 Oct;34(10):2323-8 -
"Both in vitro and
in vivo studies indicate that metformin inhibits cancer cell growth and reduces
cancer risk ... The analysis included five studies comprising 108,161 patients
with type 2 diabetes. Metformin treatment was associated with a significantly
lower risk of colorectal neoplasm (relative risk [RR] 0.63 [95% CI 0.50-0.79]; P
< 0.001). After exclusion of one study that investigated colorectal adenoma, the
remaining four studies comprised 107,961 diabetic patients and 589 incident
colorectal cancer cases during follow-up. Metformin treatment was associated
with a significantly lower risk of colorectal cancer (0.63 [0.47-0.84]; P =
0.002)" - See
metformin at IAS.
-
Alcohol Linked to Colorectal Cancer Risk - Medscape, 9/18/11 -
"Overall, the dose-risk analysis found a statistically
significant 7% increased risk for colorectal cancer for 10 g per day of alcohol
intake, which includes light alcohol consumers. According to the researchers, 1
drink is equivalent to 12 g of ethanol" - Note: My problem with
alcohol is that it increases free radicals which has to increase signs of aging
like wrinkling. It does decrease heart disease but it also increases
breast cancer, etc.
-
High
levels of 'good' cholesterol may cut bowel cancer risk - Science Daily,
3/7/11 - "Each rise of 16.6 mg/dl in HDL and of 32
mg/dl in apoA reduced the risk of bowel cancer by 22% and 18%, respectively,
after taking account of diet, lifestyle, and weight ... low HDL levels have
been linked to higher levels of proteins involved in inflammation, while
higher levels of proteins that dampen down the inflammatory response have
also been linked to high HDL levels ... The pro inflammatory proteins boost
cell growth and proliferation while curbing cell death, so HDL may alter the
inflammatory process in some way"
-
Adiponectin and adiponectin receptor in relation to colorectal cancer
progression - Int J Cancer. 2010 Dec 15;127(12):2758-67 -
"Although obesity is a risk factor for colorectal
cancer, the underlying mechanism is not clear. Adiponectin is an adipokine
that binds to 2 types of receptors, AdipoR1 and AdipoR2. The plasma
concentrations of adiponectin are reduced in obese individuals and
adiponectin has been reported to have anticarcinogenic properties.
Furthermore, AdipoR1 and AdipoR2 have been reported to be expressed in
several malignancies ... AdipoR1 and AdipoR2 immunostaining was detected in
72 and 68% of human colorectal cancer tissue, respectively. AdipoR1 and
AdipoR2 expression levels were inversely related to T stage. The lowest
AdipoR1 and AdipoR2 expression were detected in poorly differentiated
adenocarcinoma. RT-PCR also showed the expression of AdipoR1 and AdipoR2 in
HCT116 and SW620. MTT assay and TUNEL assay demonstrated the tendency of
growth inhibition and apoptosis induction in both cell lines after
full-length adiponectin treatment although statistically insignificant.
Microarray analysis revealed several gene responses to full-length
adiponectin, including upregulation of ENDOGL1 and MT1G. In conclusion,
AdipoR1 and AdipoR2 may be intimately related to the progression of
colorectal cancer"
-
Lack
of sleep found to be a new risk factor for colon cancer - Science Daily,
2/8/11 - "individuals who averaged less than six
hours of sleep at night had an almost 50 percent increase in the risk of
colorectal adenomas compared with individuals sleeping at least seven hours
per night. Adenomas are a precursor to cancer tumors, and left untreated,
they can turn malignant"
-
Anti-gout drug may decrease risk for colorectal adenoma progression -
Science Daily, 11/8/10
-
Telomere length affects colorectal cancer risk - Science Daily, 10/28/10
- "Patients with the longest telomeres -- those
patients in the 95th percentile of telomere length -- were 30 percent more
likely to develop colorectal cancer than those in the 50th percentile, the
results showed. Overall, the individuals with the shortest and the longest
telomere lengths were at an increased risk for colorectal cancer"
-
Radiation before surgery keeps colorectal cancer from returning, study finds
- Science Daily, 10/25/10
-
Higher
bone mineral density is associated with a decreased risk of colorectal
adenomas - Int J Cancer. 2010 Oct 14 - "patients
in the highest tertile of total body BMD (>1.294 g/cm(2)) and in the middle
tertile (≥1.167 to ≤1.294 g/cm(2)) compared to those with a total body BMD
in the lowest tertile (<1.167 g/cm(2)) had a lower risk of colorectal
adenomas (highest vs. lowest tertile: OR=0.29 (0.10-0.84); middle vs. lowest
tertile: OR=0.26 (0.08-0.80); p-trend=0.02)"
-
Statin use associated with statistically significant reduction in colorectal
cancer - Science Daily, 10/18/10 - "The relative risk was 0.88 (95% CI
0.84-0.93; n=22) and represents a 12% reduction in the odds of colorectal cancer among statin users ... the most common category of statins, lipophilic (which
includes atorvastatin or Lipitor®), showed the greatest effect ... long-term use
of statins is associated with reduced risk of several cancers, including breast,
prostate, lung, pancreas and liver"
-
New
recommendations issued for use of cetuximab in colon cancer therapy -
Science Daily, 7/16/10
-
Bacteria as a predicter of colorectal cancer - Science Daily, 5/25/10 -
"Several bacterial signatures were detected only in
subjects with polyps, others only in subjects without polyps. Eubacterium
ramulus was increased in the stools of subjects with polyps while
Ruminococcus sp and a human intestine firmicute were increased in subjects
without polyps. In tissue samples, Acidovorax sp. was found more frequently
in subjects with polyps. Other bacterial signatures that differed between
cases and controls were observed but did not match any know bacteria,
suggesting unidentified and uncharacterized bacteria are also present"
-
Minimally Invasive Surgery Shown Safe And Effective Treatment For Rectal
Cancer - Science Daily, 11/10/09
-
New
Old Drug Fights Colon Cancer - Science Daily, 10/13/09
-
Estrogen May Improve Colon Cancer Survival - WebMD, 9/29/09
-
Visceral
Obesity and Insulin Resistance as Risk Factors for Colorectal Adenoma: A
Cross-Sectional, Case-Control Study - Am J Gastroenterol. 2009 Sep 15 -
"insulin resistance was associated with the presence
of colorectal adenoma"
-
Evaluating More Lymph Nodes May Not Improve Identification Of Late-stage
Colorectal Cancer - Science Daily, 8/26/09
-
Alcohol And Smoking Are Key Causes For Bowel Cancer - Science Daily,
6/2/09 - "people who consume the largest quantities
of alcohol (equivalent to > 7 drinks per week) have 60% greater risk of
developing the cancer, compared with non-drinkers ... Smoking, obesity and
diabetes were also associated with a 20% greater risk of developing bowel
cancer - the same risk linked with consuming high intakes of red and
processed meat"
-
Inflammation In Colon May Get Doused Before Fueling Cancer Development -
Science Daily, 2/10/09
-
Using 2 newer drugs may
worsen colon cancer - MSNBC, 2/4/09
-
Inflammation Directly Linked To Colon Cancer; Potential New Drug Targets
Revealed - Science Daily, 2/2/09
-
Inflammation Contributes To Colon Cancer - Science Daily, 1/22/09
-
Hormone Therapy Associated With Reduced Colorectal Cancer Risk - Science
Daily, 1/8/09 - "The combination of estrogen plus
progestin, which women stopped taking in droves following the news that it
may increase their risk of breast cancer, may decrease their risk of
colorectal cancer ... Any use of estrogen therapy was associated with a 17
percent reduced risk in colorectal cancer. Among those who used estrogen,
the largest reductions were seen among those who were current users (25
percent reduced risk) and users of ten or more years duration (26 percent
reduced risk)"
-
Menopausal hormone therapy and risk of colorectal cancer - Cancer
Epidemiol Biomarkers Prev. 2009 Jan;18(1):196-203 -
"evaluated colorectal cancer risk associated with the duration and recency
of specific menopausal hormone therapy formulations (i.e., unopposed
estrogen versus estrogen plus progestin) and regimens (i.e., sequential
versus continuous estrogen plus progestin use) ... We observed a decreased
risk of colorectal cancer among ever users of unopposed estrogen therapy
(RR, 0.83; 95% CI, 0.70-0.99). Among estrogen users, the largest reduced
risk was observed for current users (RR, 0.75; 95% CI, 0.54-1.05) and users
of >/=ten years duration (RR, 0.74; 95% CI, 0.56-0.96). We found a reduced
risk among users of estrogen plus progestin therapy (RR, 0.78; 95% CI,
0.60-1.02), with sequential regimen users (progestin <15 days per cycle)
having the largest risk reduction (RR, 0.64; 95% CI, 0.43-0.95). Past users
of >/=5 years ago (RR, 0.55; 95% CI, 0.32-0.98) had the largest risk
reduction. In this study, estrogen plus progestin use, especially sequential
regimen use, was associated with the largest overall reduction of colorectal
cancer risk"
-
Metabolic Syndrome Ups Colorectal Cancer Risk - Science Daily, 10/6/08 -
"metabolic syndrome patients had a 75 percent higher
risk of colorectal cancer compared to those without metabolic syndrome"
-
Virtual Colonoscopy As Good As Other Colon Cancer Screening Methods, Study
Finds - Science daily, 9/18/08
-
New
Results Help Predict Treatment Response In Colorectal Cancer - Science
Daily, 9/17/08
-
How
Often To Screen For Colon Cancer? Study Finds 5-year Risk Extremely Low
- Science Daily, 9/17/08
-
New
Colorectal Screening Procedure Is Accurate And Less Invasive, Trial Finds
- Science Daily, 9/17/08
-
Colorectal Cancer Screening Should Start At Age 50, Study Confirms -
Science Daily, 9/2/08
-
Gene Mutation May Increase Colorectal Cancer Risk - WebMD, 8/14/08
-
Different Type Of Colon Cancer Vaccine Reduces Disease Spread, Scientists
Show - Science Daily, 6/24/08
-
Researchers See Alternative To Common Colorectal Cancer Drug - Science
Daily, 6/17/08
-
Novel Therapeutic Strategy For Colon Cancer Treatment - Science
Daily, 6/9/08
-
Combination Targeted
Therapies in Renal Cancer - Medscape, 6/9/08
-
Simvastatin induces apoptosis in human colon cancer cells and in tumor
xenografts, and attenuates colitis-associated colon cancer in mice - Int
J Cancer. 2008 Jun 2 - "colitis-associated colon
cancer (CAC) ... simvastatin could be a potential chemopreventive and
therapeutic agent of CAC as well as de novo colon cancer"
-
Drug Combo Stops Recurrent Colon Polyps - WebMD, 4/15/08 -
"A combination of the targeted anticancer agent DFMO
and the antiarthritis drug sulindac reduces the risk of recurrent colon
polyps by up to 95%"
-
Road
Map To Safer Pain Control Proposed; Cost Savings During Colonoscopies -
Science Daily, 3/11/08
-
Flat Lesions Linked to Colon Cancer - WebMD, 3/6/08
-
High-dose NSAIDs May Prevent Colon Cancer - oncologystat.com. 2/5/08 -
"people who took more than 2325 mg of aspirin weekly
reduced colon cancer risk by 21%, compared to people who took less aspirin.
Men who took 7 to 14 aspirins a week had a 28% decreased risk, and those who
took more than 14 aspirins weekly had a 70% decrease in their risk of
developing the disease. The advantages were only seen after 5 years of use,
and taking less than 1˝ pills weekly did not reduce the risk of developing
the disease. The effect was also seen with the use of other NSAIDs, such as
ibuprofen and naproxen"
-
Smoking Can Double Risk Of Colorectal Polyps - Science Daily, 2/1/08 -
"Smokers have a two-fold increased risk of
developing colorectal polyps"
-
Strong Link Between Obesity And Colorectal Cancer - Science Daily,
12/14/07 - "obese individuals (Body Mass Index*
(BMI) >30 kg/m2) have a 20% greater risk of developing colorectal cancer
compared with those of normal weight (BMI < 25 kg/m2) ... carrying even a
few excess kilos substantially increases the risk of colorectal cancer; for
every 5 kg weight gain the risk of developing the cancer increases by 7%"
-
Diabetes May Increase Woman's Risk of Colorectal Cancer -
oncologystat.com, 12/7/07 - "There was about a 50%
increased risk of colorectal cancer in women with diabetes ... The
researchers hypothesized that the elevated levels of insulin typically seen
in people with type 2 diabetes may play a central role. Insulin stimulates
the growth of normal colonic and carcinoma cells"
-
PET/CT Combination Can Highly Increase Detection Of Colorectal Cancer -
Science Daily, 10/29/07
-
Insulin Linked to Colonic Polyps, Neoplasia - oncologystat.com, 10/23/07
- "those with poorly controlled diabetes, identified
by a high serum level of hemoglobin A 1c (HbA 1c ), were significantly more
likely to have advanced colonic adenomatous polyps, compared with diabetic
patients with better glycemic control ... patients with poorly controlled
diabetes were more than sixfold as likely to have advanced polyps and nearly
sixfold as likely to have right-sided polyps, compared with patients who had
better glycemic control. The average number of polyps found in poorly
controlled patients was 5.5; in better-controlled patients, the average was
2.5 polyps per patient. Results from a third study reported at the meeting
showed that having three or more polyps was the strongest predictor of risk
for recurrent advanced neoplasia in the colon"
-
The Association of Elevated HbA1c on the Behavior of Adenomatous Polyps in
Patients with Type-II Diabetes Mellitus - Dig Dis Sci. 2007 Oct 16 -
"colonic adenomatous polyps (APs) ... univariate
analysis (UA) ... UA demonstrated that patients with poorly controlled DM-2
had a significantly increased incidence of right-sided APs (P = 0.001), a
greater number of APs (P < 0.005), more advanced APs (P < 0.005), a younger
age of presentation (P = 0.001), a history of smoking (P = 0.05), and
greater use of exogenous insulin (P = 0.01). Logistic regression, as
measured by HbA1c, demonstrated that poorly controlled DM-2 independently
predicted a greater prevalence of right-sided AP, a more advanced lesion at
the time of presentation, a greater number of polyps, and greater use of
exogenous insulin"
-
Removing Colon Polyps Cuts Death Risk - WebMD, 10/15/07 -
"The researchers analyzed data on 2,602 men and
women in the National Polyp Study, the landmark trial that showed that an
initial colonoscopy during which the colon is cleared of precancerous polyps
with regular follow-up exams significantly cut the risk of developing colon
cancer by up 90% and of dying from the cancer by up to 92%"
-
Obesity Ups Women’s Colon Cancer Risk - WebMD, 10/15/07 -
"Obesity more than doubles a woman’s risk of
developing colon cancer or growths that can lead to colon cancer"
-
Interleukin-8, Key Marker For Colorectal Cancer Treatment - Science
Daily, 10/9/07
-
Inside Job: New Radioactive Agents For Colon Cancer Work Inside Cells -
Science Daily, 10/9/07
-
Low-Dose Aspirin Plus Statins Protects Against Colorectal Cancer -
Medscape, 10/4/07 - "Dr. Brenner's group observed a
modest risk reduction of colorectal cancer among regular users of low-dose
aspirin (adjusted odds ratio = 0.77). A stronger association was found with
regular use of statins (OR 0.65). The strongest risk reduction was seen in
subjects who used combination low-dose aspirin and statins (OR 0.63),
especially if both drugs were used for at least 5 years (OR 0.38)"
-
Studies endorse 'virtual colonoscopy' - USATODAY.com, 10/4/07
-
Studies Lend Insights Into Colorectal Cancer Screening - Science Daily,
10/1/07
-
SCOUT Regimen Useful as First-Line Treatment for Metastatic Colorectal
Cancer - Doctor's Guide, 9/26/07
-
Current Chemotherapy Regimens for Advanced Colorectal Cancer Prolong
Survival - Doctor's Guide, 9/21/07
-
‘Western’ Diet Tied to Colon Cancer - WebMD, 8/14/07 -
"Colon cancer recurrences or death were nearly 3.5
times more common among patients who most closely followed a Western diet
than among patients who followed it the least"
-
Statins May Cut Colon Cancer Recurrence - Medscape, 7/26/07 -
"Just 6 of 89 patients (6.7%) treated with any
statin relapsed, as opposed to 43 of 269 (16%) patients with no statin use"
-
Flaws In Colonoscopies May Increase Risk Of Colon Cancer - Science
Daily, 5/23/07
-
Cetuximab Increases Survival In Advanced Colorectal Cancer Patients -
Science Daily, 4/19/07
-
Colon Polyp Return Likelier in Men - WebMD, 4/16/07
-
Colon Cancer Survival Linked To Number Of Lymph Nodes Examined - Science
Daily, 3/22/078/08
-
Aspirin Or NSAIDs Won't Prevent Colorectal Cancer - Science Daily,
3/20/07
-
New Combined Laparoscopy and Colonoscopy Procedure May Avoid Need for Major
Surgery - Doctor's Guide, 3/7/07
-
Avastin Slows Colon Cancer Growth - WebMD, 1/22/07
-
Lymph Node Yield Similar With Laparoscopic or Open Colectomy - Doctor's
Guide, 10/20/06
-
Adding Cetuximab (Erbitux) to First-Line Chemotherapy Boosts Results in
Metastatic Colorectal Cancer - Doctor's Guide, 10/4/06
-
FDA Approves New Colon Cancer Drug - WebMD, 9/27/06
-
Chemotherapy Does Not Improve Survival in Rectal Cancer - Medscape,
9/13/06
-
Study Finds That Vioxx Reduces The Risk Of Colorectal Polyps - Science
Daily, 8/31/06
-
FDA Approves Avastin (Bevacizumab) in Combination With Chemotherapy for
Second-Line Metastatic Colorectal Cancer Patients - Doctor's Guide,
6/21/06
-
Trial Demonstrates Safety of Oxaliplatin/5-FU Combination in Treating
Colorectal Cancer - Doctor's Guide, 6/9/06
-
Adding Cetuximab to Two Chemotherapy Regimens for Metastatic Colorectal
Cancer Appears to Enhance Overall Response and Survival - Doctor's
Guide, 6/6/06
-
Continuous Chemotherapy No More Helpful Than Retreatment in Metastatic
Colorectal Cancer - Doctor's Guide, 6/6/06
-
Virtual Colonography and Optical Colonoscopy Yield Similar Screening
Accuracy - Doctor's Guide, 5/24/06
-
Is Colonoscopy After Age 80 Worth It? - WebMD, 5/23/06
-
Women With Type 2 Diabetes at Increased Risk of Colorectal Adenomas -
Doctor's Guide, 5/23/06 - "type 2
diabetics had up to a 2- to 3-fold increased risk of having any adenoma or
advanced adenomas, which are precancerous polyps"
-
Almost 1/3 of Colon Cancer Patients Stop Chemotherapy, Leading to Double The
Death Rate - Doctor's Guide, 4/28/06
-
New Drug Combination May Enhance Effectiveness of Colorectal Cancer
Treatments - Doctor's Guide, 4/11/06
-
Smokers, Drinkers and Men Appear to Develop Colorectal Cancer at Earlier
Ages - Doctor's Guide, 3/30/06
-
Antidepressants May Cut Colon Cancer - WebMD, 3/27/06
-
Combination of Pemetrexed and Oxaliplatin Shows Activity in Metastatic
Colorectal Cancer Patients - Doctor's Guide, 1/31/06
-
Phase 2 Trial of Avastin (Bevacizumab) and FOLFIRI Produce Clinical Benefit
in Most Metastatic Colorectal Cancer Patients - Doctor's Guide, 1/30/06
-
Addition of Oxaliplatin to FOLFIRI Regimen Increases Survival of Patients
With Metastatic Colon Cancer - Doctor's Guide, 1/30/06
-
Use of Chemotherapy after Surgery for Colon Cancer Has Risen - Doctor's
Guide, 12/7/05
- Many colon
cancer patients under-treated - MSNBC, 12/7/05
-
Molecular Advances Driving New Approaches in Colorectal Cancer Treatment
- Doctor's Guide, 11/18/05
-
Treatment Advances in Colorectal Cancer Often Accompanied by Toxicity
Management Challenges - Doctor's Guide, 11/17/05
-
New Treatment Combinations Expanding Options for Patients with Early-Stage
Colorectal Cancer - Doctor's Guide, 11/17/05
-
Diabetics Face Increased Risk of Colorectal Cancer - Doctor's Guide,
11/2/05 - "hyperinsulinemia and
hyperglycemia promote the growth of colorectal cancer"
-
Xeloda plus Oxaliplatin (Xelox) Dramatically Reduces Hospital Visits by Over
60% - Doctor's Guide, 11/2/05
-
Combination Therapy with Irinotecan (CPT-11) and Pyrimidine S-1 for
Inoperable Recurrent Advanced Colorectal Cancer UEGW - Doctor's Guide,
10/21/05
-
Chemotherapy Plus Radiation Better in Preventing Local Recurrence of Rectal
Cancer - Doctor's Guide, 10/21/05
-
Dual-Drug Therapy Targets One Colon Cancer Gene - Doctor's Guide,
8/16/05
-
FDA Grants Fast Track Designation for Panitumumab for Treatment of
Metastatic Colorectal Cancer - Doctor's Guide, 8/1/05
-
Flexible Sigmoidoscopy in Early Detection of Colorectal Cancer -
Doctor's Guide, 7/7/05
-
Landmark Study Shows Oral Xeloda Could Replace Standard Intravenous 5-Fu/Lv
Chemotherapy - Doctor's Guide, 6/30/05
-
Type 2 diabetes mellitus and the risk of colorectal cancer - Clin
Gastroenterol Hepatol. 2005 Jun;3(6):587-94 -
"Type 2 diabetes mellitus is
associated with an increased risk of colorectal cancer"
-
Revolutionary Treatment Avastin (Bevacizumab) Helps People With Advanced
Colorectal Cancer Live Longer While Preserving Quality of Life -
Doctor's Guide, 6/17/05
-
Bevacizumab for Colorectal and Other Cancers - Medscape, 6/15/05
-
FDA Approves Oral Xeloda (Capecitabine) for Adjuvant Treatment of Colon
Cancer - Doctor's Guide, 6/15/05
-
Chemotherapy Options Improve For Patients With Advanced Colorectal Cancer
- Science Daily, 6/9/05
-
Oral-Based Regimen Safe, Effective for Metastatic Colorectal Cancer -
Doctor's Guide, 6/6/05
-
Cholesterol Drugs May Prevent Colon Cancer - WebMD, 5/25/05 [Abstract]
-
"people who took
cholesterol-lowering statin drugs for five years cut their colon cancer risk
in half"
-
Multi-National Trial Demonstrates Efficacy of Capecitabine (Xeloda) Compared
With 5-Fluorouracil and Leucovorin - Doctor's Guide, 5/23/05
-
Afternoon Colonoscopies Show Significantly Higher Failure Rates Than Morning
Procedures - Doctor's Guide, 5/20/05
-
What Colon Cancer Test Is Best for Women? - WebMD, 5/18/05
-
Reduced-Dose Capecitabine Effective as First-Line Therapy in Older, Less Fit
Patients With Advanced Colorectal Cancer - Doctor's Guide, 5/17/05
-
Oxaliplatin Reduces Recurrence in Early-Stage Colorectal Cancer -
Doctor's Guide, 5/17/05
-
Wireless Capsule Endoscopy Finds More Small Bowel Polyps Than Barium
Contrast Series - Doctor's Guide, 5/16/05
-
'Keyhole' Surgery Effective for Colon Cancer - WebMD, 5/12/05
-
'Virtual Colonoscopy' Effective In Finding Most Polyps But May Miss Small
Ones - Science Daily, 4/23/05
-
Transanal Endoscopic Microsurgery Effective on Early Rectal Cancer -
Doctor's Guide, 3/7/05
-
New Approach for Determining Who Should Receive Bowel Resectioning -
Doctor's Guide, 3/7/05
-
In Colorectal Liver Metastases, Complete Clinical Response Still Requires
Surgery - Doctor's Guide, 3/7/05
-
Concurrent Capecitabine With Preoperative Radiotherapy in
Rectal Cancer - Doctor's Guide, 2/4/05
- Simplified Regimen May Have Higher Efficacy Than Standard Regimen for
Advanced Colorectal Cancer - Doctor's Guide,
1/31/05
- 4-Year Data Show FOLFOX Maintains Disease-Free Survival Benefit for Adjuvant
Colorectal Cancer Patients - Doctor's Guide,
1/31/05
- Radiation Therapy Plus Irinotecan, 5-Fluorouracil and Folinic Acid Feasible,
Effective in Advanced Rectal Cancer - Doctor's
Guide, 1/31/05
- Anemia Occurs Frequently in Colerectal Cancer Patients on FOLFOX Regimens
- Doctor's Guide, 1/31/05
- First-Line Fluoroxuridine-Based Therapy Appears Active for Advanced
Colorectal Cancer - Doctor's Guide, 1/31/05
- High-Dose Bevacizumab Plus Chemotherapy Shows Survival Benefit as
Second-Line Treatment for Colorectal Cancer -
Doctor's Guide, 1/28/05
- 4-Year Data Show FOLFOX Maintains Disease-Free Survival Benefit for Adjuvant
Colorectal Cancer Patients - Doctor's Guide,
1/28/05
- Anaemia as a symptom of right colon cancer - Tech
Coloproctol. 2004 Nov;8 Suppl 1:s62-4 -
"Iron deficiency anaemia is a common symptom of right colon cancer"
- Colonoscopy Still Most Effective Colorectal Cancer Screening Method
- Doctor's Guide, 1/20/05
- Colon Cancer Screening Test Called Inaccurate -
WebMD, 1/18/05
- Red-Meat Eaters Risk Colon Cancer - WebMD, 1/11/05
- "Those who
eat the most red meat -- beef and/or pork and/or processed meat products --
get colon cancer 30% to 40% more often than those who eat these foods only
once in a while"
- Colorectal Cancer Screening Underutilized -
Doctor's Guide, 1/10/05
- New Computer-Aided Detection System Detects Colon Polyps in Colons
Previously Obscured by Contrast-Enhanced Fluid -
Doctor's Guide, 1/5/05
- The
Role of Targeted Therapies in Colorectal Cancer: An Expert Interview With
Axel Grothey, MD - Medscape, 12/23/04
- Colonoscopy Best at Detecting Colon Cancer -
WebMD, 12/16/04
- Bevacizumab Plus Oxaliplatin-Based Chemotherapy Prolongs Survival For
Previously Treated Patients With Advanced Colorectal Cancer
- Doctor's Guide, 11/29/04
- Gefitinib (Iressa) Active against Advanced Colorectal Cancer
- Doctor's Guide, 11/18/04
- Xeloda (Capecitabine) Appears To Reduce Risk Of Colon Cancer Recurrence,
Lessen Side Effects At Lower Cost Than Current Standard Treatment
- Doctor's Guide, 11/15/04
- Bevacizumab Improves Survival Among All Colorectal Cancer Subgroups
- Doctor's Guide, 11/15/04
- Panitumumab Plus Irinotecan, Fluorouracil, and Leucovorin Active as
First-Line Treatment in Metastatic Colorectal Cancer
- Doctor's Guide, 11/12/04
- Panitumumab Monotherapy Safe, Effective in Metastatic Colorectal Cancer
- Doctor's Guide, 11/12/04
- Bevacizumab-Oxaliplatin Combination Safe in Second-Line Colorectal Cancer
Treatment - Doctor's Guide, 11/12/04
- Gefitinib (Iressa) Active against Advanced Colorectal Cancer
- Doctor's Guide, 11/12/04
- Oral Capecitabine Improves Disease-Free Survival as Adjuvant Colon Cancer
Therapy - Doctor's Guide, 11/12/04
- Eloxatin (Oxaliplatin) Receives FDA Approval for the Treatment of Colon
Cancer Following Surgery (Adjuvant Treatment) -
Doctor's Guide, 11/5/04
- Staged Combination Treatment a Gentler Option for Advanced Colorectal Cancer
Patients - Doctor's Guide, 11/4/04
- Ibandronate Reduces Bone Complications in Colorectal Cancer Patients With
Bone Metastases - Doctor's Guide, 11/1/04
- Gout Drug Prevents Colon Cancer - WebMD, 10/18/04
- "Zyloprim reduced risk of colon
cancer by two-thirds"
- Insulin May Increase Colon Cancer Risk - WebMD,
10/1/04 - "people with diabetes who
had been taking insulin for three to five years had almost a threefold
increase in colorectal cancer risk compared with those who did not take
insulin ... The risk was even higher in people who took insulin for more
than five years"
- Confocal Laser Colonoscopy May Accurately Diagnose Colorectal Cancer
- Medscape, 9/29/04
- Colonoscopy Remains Most Sensitive, Best Test for Colorectal Cancer
Screening - Doctor's Guide, 9/7/04
- Colonoscopy Doesn't Find All Polyps - WebMD,
9/6/04
- Virtual Colonoscopy Showing Promise as Colorectal Cancer Screening Option
- Doctor's Guide, 9/1/04
- Study Shows Colonoscopy Misses 4% of Cancers -
WebMD, 8/30/04
- New Colon Cancer Guideline On Chemotherapy For Stage II Colon Cancer
- Doctor's Guide, 8/17/04
- Are Physicians Over-Performing Colonoscopy? -
Doctor's Guide, 8/17/04
- Too Many Repeat Colonoscopies Performed - WebMD,
8/16/04
- ASCO Releases New Guideline on Chemotherapy for Stage II Colon Cancer
- Doctor's Guide, 8/16/04
- Colon Cancer: Prevention and Early Detection
- Physician's Weekly, 8/9/04
- Adjuvant Chemotherapy For Colon Cancer Offers No Survival Benefit After 10
Years - Science Daily, 8/9/04
- Anastomotic Leak After Colorectal Cancer Surgery Linked to Lower Survival
- Medscape, 8/6/04
- Erbitux (Cetuximab) Appears to Slow Disease Progression in Metastatic
Colorectal Cancer - Doctor's Guide, 7/22/04
- Cetuximab Helpful in Irinotecan-Resistant Colon Cancer
- Medscape, 7/21/04
- Current Issues in Systemic Treatment of Advanced Colorectal Carcinoma
- Doctor's Guide, 7/9/04
- Bevacizumab Plus Fluorouracil-Based Chemotherapy is a New Option for
Patients With Metastatic Colorectal Cancer -
Doctor's Guide, 6/18/04
- Oxaliplatin Plus Fluorouracil and Leucovorin Improves Standard Adjuvant
Therapy in Patients With Colon Cancer - Doctor's
Guide, 6/17/04
- Oral Capecitabine (Xeloda) as Effective as Bolus 5-Fluorouracil/Leucovorin
for Adjuvant Treatment of Colon Cancer - Doctor's
Guide, 6/10/04
- Oral Uracil/Tegafur as Effective as Bolus 5-fluorouracil for Adjuvant
Treatment of Stage II or III Colon Cancer -
Doctor's Guide, 6/10/04
- Bleeding Negligible in Colorectal Cancer Patients on Anti-Coagulation and
Bevacizumab Therapy - Doctor's Guide, 6/9/04
- Statin Use Appears to Reduce Risk of Colorectal Cancer
- Doctor's Guide, 6/7/04
- Statin Drugs May Cut Colon Cancer Risk - WebMD,
6/7/04 - "When
they added in those factors, "use of statins was still associated with a 46%
reduction in risk.""
- FOLFOX4 (Oxaliplatin, Leucovorin, and Fluorouracil) Regimen Benefits
Patients With Stage II Colon Cancer - Doctor's
Guide, 6/6/04
- Presurgical Radiation and Chemotherapy Increased Complete Response Rate in
Rectal Cancer - Doctor's Guide, 6/6/04
- Disease-Free Survival Rates Improve With the Addition of Oxaliplatin to
Adjuvant Fluorouracil Plus Leucovorin for Resected Colon Cancer
- Doctor's Guide, 6/3/04
- Drug That Cuts Off Tumor's Blood Supply Extends Lives Of Colorectal Cancer
Patients - Science Daily, 6/3/04
- Fluorouracil-Based Chemotherapy Plus Bevacizumab Increased Survival Rates
for Patients with Metastatic Colorectal Cancer -
Doctor's Guide, 6/2/04
- Longer Survival With Colorectal Cancer Drugs -
WebMD, 6/2/04
- Easier, Safer Colon Cancer Test? - WebMD, 5/19/04
- New Colon
Cancer Test? - Dr. Weil, 5/18/04
- Recurrence Rates Similar After Laparoscopic or Open Colectomy for Colon
Cancer - Doctor's Guide, 5/14/04
- Study Compares Colon Cancer Surgeries -
Intelihealth, 5/13/04
- Looking Good: Colon Cancer Keyhole Surgery -
WebMD, 5/12/04
- Computer-Aided Detection Acts as "Intelligent Colleague" in Detecting Polyps
in the Colon - Doctor's Guide, 5/6/04
- Irinotecan/Raltitrexed Combination May be Effective Treatment for Advanced
Colorectal Cancer - Doctor's Guide, 4/27/04
- Computed Tomographic Colonography Less Sensitive, Less Specific in Lesion
Detection than Conventional Colonoscopy - Doctor's
Guide, 4/13/04
- Virtual Colonoscopy Not Ready for Use Yet - WebMD,
4/13/04
- Laparoscopy, Conventional Resection Result in Similar Disease Control and
Survival in Patients with Rectosigmoid Carcinoma -
Doctor's Guide, 4/12/04
- Circadian-Timed Infusion of 5-Fluorouracil Plus Mitomycin-C No More
Effective Than Protracted Venous Infusion, May Be More Toxic
- Doctor's Guide, 4/8/04
- Laparoscopic Surgery Works for Colon Cancer -
WebMD, 4/8/04
- Pre-Diabetes Increases Colon Cancer Risk - WebMD,
4/6/04
- New Guidelines Outline Metastatic Colon Cancer Treatment Choices
- Doctor's Guide, 3/18/04
- New Drugs Incorporated Into Colon Cancer Guidelines
- Doctor's Guide, 3/15/04
- Colon Cancer Screening - Physician's Weekly,
3/15/04
- Erbitux (Cetuximab) Receives FDA Approval to Treat Irinotecan Refractory Or
Intolerant Metastatic Colorectal Cancer - Doctor's
Guide, 2/13/04
- Oxaliplatin/Capecitabine Combination Effective First- and Second-Line
Therapy in Metastatic Colorectal Cancer - Doctor's
Guide, 2/12/04
- Combination of Oxaliplatin, 5-fluoruracil, and Folinic Acid Boosts Response
Rate in Advanced Colorectal Cancer - Doctor's
Guide, 2/12/04
- Colorectal Cancer Patients Treated By Fluorouracil-Leucovorin May Be At High
Risk For Venous Thromboembolism - Doctor's Guide,
2/11/04
- Preoperative Radiation Combined With Oxaliplatin and Capecitabine Effective
and Well Tolerated for Advanced Colorectal Cancer
- Doctor's Guide, 2/11/04
- Oxaliplatin/Capecitabine Regimen Appears Effective, Tolerable for Advanced
Colorectal Carcinoma Patients - Doctor's Guide,
2/10/04
- High-Glycemic Foods Linked to Colon Cancer -
WebMD, 2/3/04 -
"the future risk of colorectal cancers is nearly three times higher in women
who eat the most high glycemic-load foods
compared with those who eat lesser amounts"
- Link Found Between High C-Reactive Protein Levels and Subsequent Colon
Cancer Development - Doctor's Guide, 2/3/04 -
"Elevated plasma concentrations of
C-reactive protein (CRP) appear to increase the risk of developing colon
cancer"
- Elderly or Compromised Patients Do Better with Capecitabine in Advanced
Colorectal Cancer - Doctor's Guide, 1/26/04
- Positron Emission Tomography Steers Surgeons Away From Unnecessary
Colorectal Cancer Surgery - Doctor's Guide,
1/26/04
- Infused 5-Fluorouracil May Prove Superior to Bolus for Colorectal Cancer
- Doctor's Guide, 1/26/04
- Higher Dose of Bevacizumab Safe and Effective as Addition to Colorectal
Cancer Chemotherapy - Doctor's Guide, 1/26/04
- Bevacizumab May Safely and Effectively Combine With Chemotherapy for
Colorectal Cancer - Doctor's Guide, 1/26/04
- Addition of Oxaliplatin To Bolus Schedule Of Fluroruracil Plus Folinic Acid
Appears Safe, Effective In Treatment Of Metastatic Colorectal Cancer
- Doctor's Guide, 1/22/04
- FDA Approves Eloxatin (Oxaliplatin) for Treatment of Advanced Colorectal
Cancer - Doctor's Guide, 1/12/04
- Chemotherapy Regimen Including Irinotecan Followed By Oxaliplatin May Offer
Improved Survival For Colorectal Cancer Patients -
Doctor's Guide, 12/29/03
- Capecitabine Shows Improved Safety Over 5-fluorouracil-based Adjuvant
Treatment for Colon Cancer - Doctor's Guide,
12/4/03
- 3-D
Colonoscopy Produces Results Equivalent to Those of Conventional Procedure
- Medscape, 12/2/03
- Virtual Colonoscopy at Least Equal in Efficacy to Conventional
- Doctor's Guide, 12/2/03
- Virtual Colonoscopy Shows Promise - WebMD, 12/1/03
-
Additional Study With Avastin in Metastatic Colorectal Cancer
Shows Significant Increase in Progression-free Survival
- Doctor's Guide, 11/27/03
-
EKB-569 Combined With Capecitabine Safe in Advanced
Colorectal Cancer - Doctor's Guide, 11/20/03
-
Combination of Gefitinib and FOLFOX-4 Shows Promise in
Metastatic Colorectal Cancer - Doctor's Guide,
11/20/03
-
Preoperative Concurrent Chemotherapy and Radiation Improves
Local Control of Rectal Cancer - Doctor's Guide,
10/31/03
-
Virtual Colonoscopy Not Ready for Prime Time
- Doctor's Guide, 10/22/03
-
Heavy Alcohol Use Linked to Colon Cancer
- Doctor's Guide, 10/22/03 -
"Individuals
who drink nine or more drinks made with distilled spirits a week for 10
years or more are about three times more likely to develop significant
left-sided colorectal pathology than teetotalers"
-
Spirits Raise Colon Cancer Risk -
WebMD, 10/14/03
-
Capecitabine Effective With Either Irinotecan or Oxaliplatin
for Advanced Colorectal Cancer - Doctor's Guide,
10/2/03
-
Adjuvant Chemotherapy Beneficial For Selected Patients With
Colorectal Cancer - Doctor's Guide, 10/2/03
-
Capecitabine/Oxaliplatin Combination is Tolerable First-Line
Treatment for Advanced Colorectal Cancer -
Doctor's Guide, 10/2/03
-
Gemcitabine/5-Fluorouracil Does Not Appear To Be More
Effective In One Metastatic Renal Cancer Subgroup Over Another
- Doctor's Guide, 10/1/03
-
Oral Capecitabine Plus Irinotecan Lowers Burden on Healthcare
Workers and Patients with Advanced Metastatic Colorectal Cancer
- Doctor's Guide, 9/22/03
-
FDA Grants Priority Review to Eloxatin (Oxaliplatin) for
First-Line Treatment of Metastatic Colorectal Cancer
- Doctor's Guide, 9/17/03
-
Comparable Detection Rates Between Multidetector-Array
Computed-Tomographic Colonography And Colonoscopy
- Doctor's Guide, 9/5/03
-
Chemotherapy and Radiation Therapy Before Surgery Leads to
Improved Sphincter Control for Rectal Cancer Patients
- Doctor's Guide, 9/4/03
-
The Humanised Monoclonal Antibody, Bevacizumab, Prolongs Time
to Progression in Patients with Metastatic Renal-Cell Carcinoma
- Doctor's Guide, 8/1/03
-
Fluorouracil-Based Chemotherapy May Not Benefit Colon Cancer
Showing High-Frequency Microsatellite Instability
- Doctor's Guide, 7/29/03
-
Bevacizumab (Avastin) Demonstrates Trend Toward Survival In
Metastatic Colorectal Cancer - Doctor's Guide,
7/15/03
-
Colorectal Cancer: Questioning the Digital Exam
- Physician's Weekly, 7/14/03
-
Percutaneous Radiofrequency Ablation Decreases Number Of
Resections Needed For Liver Metastases - Doctor's
Guide, 7/11/03
- Oral
Antibiotic Prophylaxis Unnecessary Before Colorectal Surgery
- Medscape, 6/25/03
- All
Colorectal Polyps Should Be Treated - Medscape,
6/25/03
-
Chemo-Radiation Before Surgery Offers Hope To Patients With
Rectal Cancer - Doctor's Guide, 6/20/03
-
Carbs, Sugar Don't Raise Colon Cancer Risk
- WebMD, 6/17/03
-
Irinotecan Addition to Chemotherapy Improves Colorectal
Cancer Progression-Free Survival - Doctor's Guide,
6/17/03
-
FOLFOX4 Shows Efficacy in Second-Line Treatment of Metastatic
Colorectal Cancer - Doctor's Guide, 6/16/03
-
Cetuximab/Irinotecan Combination Slows Progression of Colon
Cancer - Doctor's Guide, 6/3/03
-
DNA Test Might Predict Toxicity of Irinotecan
- Doctor's Guide, 6/2/03
-
Irinotecan Addition To Chemotherapy Improves Colorectal
Cancer Survival - Doctor's Guide, 6/2/03
-
Oxaliplatin Plus 5-Fluorouracil and Leucovorin Combination
Effective in Second-Line Metastatic Colorectal Cancer Treatment
- Doctor's Guide, 6/2/03
-
Adjuvant Therapy with Oxaliplatin Increases Disease-Free
Colorectal Cancer Survival - Doctor's Guide,
6/2/03
-
Colonoscopy Patients Prefer Liquid Sodium Phosphate to
Tablets - Doctor's Guide, 5/20/03
-
Computed Tomography Colonography Reduces Radiation Risk In
Colon Cancer Screening - Doctor's Guide, 5/7/03
-
Alternative Method For Colon Cancer Screening More
Comfortable For Patients - Doctor's Guide, 5/7/03
-
Colonoscopy More Cost-Effective Against Colon Cancer Than
Promising Cox II Drugs, Study Predicts - Doctor's
Guide, 5/7/03
-
Capsule with Microscopic Camera Provides Better Look at Small
Bowel - Doctor's Guide, 5/6/03
-
Sigmoidoscopy: How Often Is Enough?
- WebMD, 4/15/03
-
Radiotherapy Plus Oxaliplatin/Fluorouracil Effective For
Preoperative Rectal Cancer - Doctor's Guide,
3/27/03
-
Carbon Dioxide Causes Less Pain Than Air In Insufflation For
Colonoscopy - Doctor's Guide, 3/24/03
-
Newer Drugs Added to Colorectal Cancer Guidelines
- Doctor's Guide, 3/14/03
-
Colon Cancer Screening Rates Still Too Low
- WebMD, 3/13/03
-
Colon Cancer Subset: 5-FU Combo Better With Leucovorin Than
Levamisole - Doctor's Guide, 2/28/03
-
Colon Polyp Recurrence High -
WebMD, 2/24/03
-
Three Methods of Colon Cleansing Equally Effective in
Colonoscopy Patients - Doctor's Guide, 2/17/03
-
Which Colon Screening Method is Safest?
- WebMD, 2/4/03
-
Colorectal Cancer Screening Revisited
- WebMD, 2/3/03
- New
Guidelines for Colorectal Cancer Screening -
Medscape, 2/3/03
-
Recurrent And New Symptoms Are Common After Surgery For
Rectal Cancer - Doctor's Guide, 1/16/03
-
New Drug (Avastin) Improves Colon Cancer Survival
- WebMD, 1/3/03 - See my
Avastin page.
-
Pill-Sized Camera Detects Bowel Abnormalities Missed By Other
Diagnostic Tools - Doctor's Guide, 12/4/02
- Colon Cancer Test -- Once May Be Enough - WebMD,
12/3/02
-
Thalidomide Shows Promise in Treatment of Renal Cell
Carcinoma - Doctor's Guide, 11/15/02
-
Ranitidine Proves Independently Beneficial For Selected
Patients Following Resection Of Colorectal Tumours
- Doctor's Guide, 11/5/02
- New Cancer Vaccine Starves Tumors - WebMD, 11/5/02
-
"Mice that
were given the vaccine showed slowed blood vessel growth and were able to
fend off tumors when injected with three different types of cancer cells
(melanoma, colon, and lung)"
-
Bile Acid May Reduce Polyp Recurrence in Resected Colon
Cancer Patients - Doctor's Guide, 10/24/02
-
Test for Abnormal DNA May Help Monitor Colon Cancer Patients
- Doctor's Guide, 10/24/02
-
Oxaliplatin in Combination with 5-Fluorouracil and Leucovorin
Offers New Hope for Metastatic Colorectal Cancer Patients Who Fail First
Line Treatment - Doctor's Guide, 10/23/02
- Smoking an Important Risk Factor for Colorectal Polyps
- Medscape, 10/22/02
- Oxaliplatin Helpful in Metastatic Colon Cancer -
Medscape, 10/23/02
-
Anti-inflammatory Drugs May Require Two Years' Treatment to
Prevent Colorectal Cancer - Doctor's Guide,
10/22/02 -
"Taking
aspirin or an NSAID
for at least two years reduced the risk of colorectal cancer by 32 percent"
-
Colorectal Cancer Follow-up Cuts Death Risk by Nearly
One-Half - Doctor's Guide, 10/22/02
-
Polyps Burden in Women Similar in the 50s and 60s
- Doctor's Guide, 10/22/02
-
Abnormal Lesions Seen in 25 Percent of Patients Assigned to
Colonoscopy - Doctor's Guide, 10/22/02
-
ImClone Resumes Erbitux Tests -
Intelihealth, 10/5/02
-
Brachytherapy for Rectal Cancer a Good Alternative when
Radical Surgery is Not Possible - Doctor's Guide,
9/20/02
-
Short-Term Preoperative Radiotherapy Plus Total Mesorectal
Excision an Option for Advanced Resectable Rectal Cancer
- Doctor's Guide, 9/18/02
-
Oral Tegafur May Be Good Alternative to 5-Fluorouracil in
Preoperative Rectal Cancer Treatment - Doctor's
Guide, 9/18/02
-
Radiation Therapy Alone Can Treat Rectal Cancer
- Doctor's Guide, 8/27/02
-
Colon-Cancer Test Supposedly Easier
- Intelihealth, 8/21/02
-
Pre-op Radiotherapy Alternative to Lymphadenectomy for Rectal
Cancer - Doctor's Guide, 8/13/02
-
ELOXATIN, Chemotherapy for Advanced Colorectal Cancer,
Receives Approval from the U.S. Food and Drug Administration
- Doctor's Guide, 8/12/02
-
Colorectal Tumour Regression Measured by Magnetic Resonance
Imaging - Doctor's Guide, 7/25/02
-
Premenopausal Obesity Doubles Colorectal Cancer Risk
- Doctor's Guide, 7/18/02
- Laparoscopy May Be Better Than Open Colectomy for Colon Cancer
- Medscape, 6/28/02
-
Aspirin Can Be Safely Used Before and After Colonoscopy
- Doctor's Guide, 6/10/02
-
Stanford Researcher Advocates Aggressive, Preventive Anal
Cancer Treatment - Doctor's Guide, 6/10/02
-
New Study by Ochsner Clinic Foundation Determines How
Frequently High-Risk Patients Should be Screened for Colorectal Cancer
- Doctor's Guide, 6/7/02
-
Neoadjuvant Therapy Recommended for All Cancers with
Preoperative T3 Staging - Doctor's Guide, 6/6/02
-
Tumor Margin "Budding" Predicts Recurrence and Should
Influence Adjuvant Therapy Decision - Doctor's
Guide, 6/6/02
-
Is Transanal Excision Adequate for T1 Rectal Cancer?
- Doctor's Guide, 6/6/02
-
Routine Colonoscopy Screening For Colorectal Cancer Not
Needed In Asymptomatic People In 40s - Doctor's
Guide, 6/6/02
- Easier Colorectal Cancer Screening Option - WebMD,
5/30/02 -
"British
researchers have developed a new fecal test that detects cancerous cells in
stool samples"
-
New Stool Test Developed For Colorectal Cancer
- Doctor's Guide, 5/30/02
-
"Smart Tablet" Xeloda (Capecitabine) Is Highly Effective And
Makes Chemotherapy Easier For Patients - Doctor's
Guide, 5/24/02
-
Physicians Often Skimp on Family Histories for Colorectal
Cancers - Doctor's Guide, 5/23/02
-
New Occult Blood Tests Highly Specific but Have Low
Sensitivity - Doctor's Guide, 5/23/02
-
Colorectal Cancer Rate Fails to Justify Frequent Screens
- Doctor's Guide, 5/21/02
-
New Colon Cancer Tests Planned -
Intelihealth, 5/13/02
-
Single Flexible Sigmoidoscopy Mass Screen A Success
- Doctor's Guide, 4/12/02
-
Intensive Follow-up Improves Colorectal Cancer Survival
- Doctor's Guide, 4/10/02
-
Low Dose Aspirin Associated With Reduced Risk For Recurrent
Adenomas - Doctor's Guide, 4/8/02
-
Positron Emission Tomography Scans Reduce Unnecessary
Colorectal Surgeries - Doctor's Guide, 4/5/02
-
Anti-Inflammatory [sulindac] Fails To Head Off Hereditary
Colon Cancer - Doctor's Guide, 4/4/02
-
Total Mesorectal Excision Using Laparoscopy Allows for More
Precise Dissection in Rectal Cancer - Doctor's
Guide, 3/18/02
-
In Rectal Cancer, Laparoscopic Resection Does Not Raise Risk
of Local Recurrence - Doctor's Guide, 3/15/02
-
Encouraging Preliminary Results Seen for I-131 in Advanced
Colorectal Cancer - Doctor's Guide, 2/28/02
- Doctors May Miss Second Colon Cancer - WebMD,
2/19/02
-
Second Colorectal Cancers Often Develop Despite Follow-Up
Tests - Intelihealth, 2/19/02
-
Video pill makes 'fantastic voyage' inside body
- CNN, 2/7/02
- New Colon Cancer Test Shows Promise - WebMD,
1/30/02
-
Test May Help Halt Colon Cancer Early
- Intelihealth, 1/18/02
-
Laparoscopic-Assisted Colectomy Rejected For Colon Cancer
- Doctor's Guide, 1/16/02
-
New Procedure Holds Promise For The Wary - And For Earlier
Detection - Intelihealth, 1/8/02
-
Anti-colorectal cancer drug faces FDA obstacle
- USA Today, 1/3/02
-
Phosphate Tablets Better for Pre-Colonoscopy Colon Cleansing
- Doctor's Guide, 12/13/01
- Colon
Cancer Test Points To Most Effective Treatments -
Doctor's Guide, 11/30/01
-
U.S. Researchers Find Lag In Colon Cancer Testing
- Intelihealth, 11/21/01
- Raltitrexed/Oxaliplatin Effective For Refractive Advanced or Metastatic
Colorectal Cancer - Doctor's Guide, 10/25/01
- Intrahepatic Route no Better than Intravenous for 5-Fluorouracil/Leucovorin
in Metastatic Colorectal Cancer - Doctor's Guide,
10/25/01
- Oral
Xeloda (Capecitabine) Plus Intravenous Oxaliplatin Shows Good Efficacy and
Tolerability in Advanced Colorectal Cancer -
Doctor's Guide, 10/25/01
- Xeloda
(Capecitabine)/Eloxatin (Oxaliplatin) Combo Highly Effective in Colorectal
Cancer - Doctor's Guide, 10/24/01
- FDA
Grants Fast Track Status to Cancer Vaccine, Oncophage (HSPPC-96)
- Doctor's Guide, 10/12/01
- Older Colon Cancer Patients Should Receive Same Treatment
- WebMD, 10/10/01
-
An InteliHealth/Harvard Look At The News -- Colon Cancer
Tests - Intelihealth, 8/23/01
- Colorectal Cancer Tests Are Not Created Equal -
WebMD, 8/22/01
- American
Medical Association Announces New Screening/Surveillance Guidelines for
Colorectal Cancer - Doctor's Guide, 7/20/01
- Better
Response Rate With Irinotecan + 5-FU + Irradiation In Rectal Cancer Patients
- Doctor's Guide, 6/27/01
-
Study Suggests Link Between Processed Meat And Cancer But Not
Fresh Red Meat - Intelihealth, 6/22/01 -
"Eating lots
of preserved meats such as salami, bacon, cured ham and hot dogs could
increase the risk of bowel cancer by 50 percent"
- Viagra
(Sildenafil) Effective For Erectile Dysfunction Associated with Rectal
Cancer - Doctor's Guide, 6/7/01
- Chemotherapy and Radiation Just as Effective as Surgery in Some Rectal
Cancers - Doctor's Guide, 6/5/01
- Virtual
Colonoscopy May Provide Effective Alternative To Invasive Colonoscopy
- Doctor's Guide, 5/30/01
-
Colon Cancer Treatment May Be More Toxic Than Thought, Triple-Drug Therapy
Causes Severe Side Effects, Death - WebMD, 5/17/01
-
Tests On Cancer Drug Suspended Over Toxicity Findings - Intelihealth,
5/17/01
- Theratope
Vaccine Lengthens Survival In Colorectal Cancer Patients - Doctor's
Guide, 5/15/01
- CancerVax
Therapeutic Vaccine Induces Strong Immune Response In Late Stage Colorectal
Cancer - Doctor's Guide, 5/15/01
- Blood
Test Predicts Colon Cancer Response To Chemotherapy Pill, Xeloda
(Capecitabine) - Doctor's Guide, 5/14/01
-
Colon cancer drug may shrink tumors, extend lives - CNN, 5/14/01 -
"In a study of 121 patients with
end-stage colon cancer that didn't respond to chemotherapy, one out of five
saw their tumors treated with C225 shrink by 50 percent or more ... C225,
delivered intravenously, works by limiting a cancer cell's access to growth
factor, which many cells need to survive. That makes the cancer cells
weaker, and therefore more vulnerable to chemotherapy"
-
Doctors Encouraged By Cancer Drug - Intelihealth, 5/13/01 -
"they expect the medicine to become
a standard treatment for colon cancer and probably other tumors, as well ...
The latest treatment, code-named IMC-C225, produced no cures, but it did
shrink tumors by at least half in nearly one-quarter of patients with
end-stage colon cancer"
- Antibody
IMC-C225 Appears Promising In Refractory Colorectal Patients - Doctor's
Guide, 5/12/01
-
FDA Approves First Oral Drug for Colorectal Cancer, Xeloda Lets Patients
Avoid Needles, Hospital Visits, Hair Loss - WebMD, 5/1/01
- FDA
Approves Xeloda (Capecitabine), First Oral Chemotherapy for Treatment of
Colorectal Cancer - Doctor's Guide, 5/1/01
-
Oral Contraceptive Use May Lower Colorectal Cancer Risk - WebMD, 4/19/01
-
"Combined findings from several
studies point to a lower risk of colorectal cancer in women who have used
oral contraceptives"
-
The pill might protect against colon cancer
- USA Today, 4/16/01
-
Study Indicates Contraceptive Might Protect Women From Bowel Cancer -
Intelihealth, 4/16/01 -
"women had about a 20 percent lower
chance of developing the disease if they used oral contraceptives"
-
Chemotherapy pill causes fewer side effects - CNN, 4/13/01 -
""Toxicity was substantially less
with pills. The risk of hospitalization was 20 percent with the IV drug; 11
percent with the pill. Nausea, hair loss and diarrhea were lessened by the
pill, too." He added that the treatment is more convenient and less toxic
than intravenous chemotherapy."
- Hormone
Replacement Therapy Not Beneficial In Preventing Polyp Recurrence
- Doctor's Guide, 3/28/01
-
Synergistic Effect Seen With Irinotecan (CPT-11) And Oxaliplatin In
Combination And Sequentially - Doctor's Guide, 3/26/01
- Patients
Prefer New Oral Chemotherapy For Colorectal Cancer - Doctor's Guide,
3/9/01
-
Over 50? Schedule Your Colon Cancer Screening - WebMD, 3/8/01
-
Researchers Discover New Ways to Predict Advanced Colorectal Cancer Risk
- Doctor's Guide, 2/13/01
-
Cigarette smoking linked to colorectal cancer - CNN, 12/6/00
- Virtual
Colonoscopy Found Highly Accurate For Cancer Detection, Staging
- Doctor's Guide, 11/27/00
- There's
Something Fruits and Veggies Appear Not to Prevent - WebMD, 10/31/00
- COX-2 Inhibitors Shown
Effective For Reducing Risk of Colon Cancer - Doctor's Guide, 10/18/99
-
New Colon Cancer Test Developed - Intelihealth, 10/26/00
- Experimental
Test for Colon Cancer Is Painless, Faster - WebMD, 10/24/00
-
DNA testing may help detect colon cancers earlier - CNN, 10/24/00
- SU5416 Showing Promise
in Controlling, Shrinking Colorectal Cancer Tumors - Doctor's Guide,
10/13/00
-
New Drug For Colorectal Cancer, Plus Standard Ones, Improves Survival -
Intelihealth, 9/28/00
- New Hope for
Colon Cancer Patients - WebMD, 9/27/00
- Lighting Up May
Be Hazardous to Your Colon - WebMD, 7/21/00
-
Sigmoidoscopy May Miss Cancer - Intelihealth, 7/20/00
- Surgical
Technique May Catch Spread of Colon Cancer Earlier
- Doctor's Guide, 7/6/00
-
New Prevention Weapon for Those at Risk for Colon Cancer - WebMD,
6/29/00
- CT Scans
Improve Disease Management In Colon Cancer -
Doctor's Guide, 6/29/00
- Studies
Suggest Possible Role Of COX-2 Inhibitor For Familial Adenomatous Polyposis
- Doctor's Guide, 6/2/00
-
Experimental Drug Strangles Cancer's Blood Supply - WebMD, 5/23/00
- FDA
Approves Camptosar (Irinotecan Hydrochloride) In Combo Therapy For
Metastatic Colorectal Cancer - Doctor's Guide, 4/24/00
-
FDA OKs Colorectal Cancer Treatment - Intelihealth, 4/21/00
-
Diet's Anti-Cancer Benefits Doubted - Intelihealth, 4/20/00
- Patients
With Metastatic Colorectal Cancer May Benefit From Xeloda (Capecitabine)
- Doctor's Guide, 4/19/00
- Camptosar
(Irinotecan) In Combo Therapy Improves Survival In Metastatic Colorectal
Cancer - Doctor's Guide, 3/27/00
-
Laparoscopic Surgery For Diagnosing Colon Cancer Not Yet Proven Beneficial
- Doctor's Guide, 3/21/00
- FDA
Committee Recommends Camptosar (Irinotecan) For Colorectal Cancer -
Doctor's Guide, 3/17/00
- Combined
Therapies Increase Life Expectancy With Metastatic Colorectal Cancer
- Doctor's Guide, 12/30/99
- Chemo And
Radiation Cut Liver Metastases - Doctor's Guide, 11/2/99
- Estrogen
Reduces Risk Of Colorectal Cancer - Doctor's Guide, 10/28/99
- Aptosyn
Effective In Preventing Pre-cancerous Colon Polyps - Doctor's Guide,
10/28/99
- Celecoxib
Reduces Number And Size Of Colorectal Polyps - Doctor's Guide, 10/21/99
- How
Sulindac Prevents Colon-Cancer - Doctor's Guide, 9/20/99
- New Data
Demonstrates Survival Benefits Of Camptosar In Colon Cancer - Doctor's
Guide, 9/17/99
- FDA
Advisory Committee Recommends UFT Plus Leucovorin For Colorectal Cancer
- Doctor's Guide, 9/16/99
-
Colorectal cancer: Find it before it finds you - CNN, 6/14/99
- Breast
Cancer Drug (Xeloda (capecitabine))Works In Colon - Doctor's Guide,
5/19/99
- Orzel
Significantly Safer Than Traditional IV Treatment For Colorectal Cancer
- Doctor's Guide, 5/17/99
-
Colon cancer vaccine appears to prevent recurrence - CNN, 1/28/99
- Estrogen
May Reduce Colorectal Cancer Risk In Postmenopausal Women - Doctor's
Guide, 9/24/98
- Scientists
Discover New Link To Colon Cancer - Doctor's Guide, 7/21/98
- Link Shown
Between Insulin Resistance, Colon And Breast Cancer - Doctor's Guide,
6/12/97 - "Results showed that nearly 27 percent of
the women who died from colon cancer had insulin resistance, compared to 3
percent of the controls"
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