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Home > Health Conditions > Diabetes > Onglyza
(saxagliptin)
Onglyza (saxagliptin)
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News & Research:
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Metformin vs. Sulfonylureas for Diabetes - WebMD, 12/4/09 -
"Researchers reported that diabetes patients who
used sulfonylureas had a higher risk of death from all causes and a higher
risk of heart failure than diabetes patients who used the most widely
prescribed diabetes drug, metformin ... Compared with metformin, also known
as Glucophage, single-drug treatment with first- and second-generation
sulfonylureas was associated with up to a 61% increased risk for death.
Users of second-generation sulfonylureas had up to a 30% higher risk for
congestive heart failure ... Patients treated with Actos or Avandia did not
appear to have a greater risk for heart attacks than those treated with
metformin"
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FDA Approves Saxagliptin for Type 2 Diabetes - Doctor's Guide, 7/31/09 -
"Although saxagliptin was not associated with an
increased risk for cardiovascular events in patients who were mainly at low
risk for these events, the FDA is requiring a post-market study that will
specifically evaluate cardiovascular safety in a higher risk population"
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