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Home > Health Conditions > Diabetes > Januvia
(sitagliptin)
Januvia (sitagliptin phosphate)
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News & Research:
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Januvia (sitagliptin phosphate) - rxlist.com - "By increasing and prolonging active incretin levels, JANUVIA increases insulin release and decreases glucagon
levels in the circulation in a glucose-dependent manner"
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Metformin vs. Sulfonylureas for Diabetes - WebMD, 12/4/09 -
"Researchers reported that diabetes patients who
used sulfonylureas had a higher risk of death from all causes and a higher
risk of heart failure than diabetes patients who used the most widely
prescribed diabetes drug, metformin ... Compared with metformin, also known
as Glucophage, single-drug treatment with first- and second-generation
sulfonylureas was associated with up to a 61% increased risk for death.
Users of second-generation sulfonylureas had up to a 30% higher risk for
congestive heart failure ... Patients treated with Actos or Avandia did not
appear to have a greater risk for heart attacks than those treated with
metformin"
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Two-Year Sitagliptin With or Without Metformin Shows Strong and Durable
Effects in Type 2 Diabetes - Doctor's Guide, 9/10/08
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FDA Approves New Treatment for Diabetes - Doctor's Guide, 10/17/07 -
"Januvia prolongs the activity of proteins that
increase the release of insulin after blood sugar rises, such as after a
meal. Januvia does this by blocking an enzyme (dipeptidyl peptidase IV or
DPP-IV) which breaks down these proteins, leading to better blood sugar
control"
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FDA Approves Once-Daily Januvia(TM) (Sitagliptin Phosphate), the First and
Only DPP-4 Inhibitor Available in the United States for Type 2 Diabetes
- Doctor's Guide, 10/18/06 - "By
adding Januvia to the insulin sensitizers metformin or pioglitazone (a TZD),
the three key defects of type 2 diabetes can be addressed: insulin
resistance, beta-cell dysfunction (decreased insulin release), and
alpha-cell dysfunction (unsuppressed hepatic glucose production)"
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FDA
OKs New Type 2 Diabetes Drug - WebMD, 10/17/06
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New oral
diabetes drug gets FDA approval - MSNBC, 10/17/06 -
"The Food and Drug Administration
said it approved Januvia, which enhances the body’s own ability to lower
blood sugar levels, after clinical trials showing the new pill works just as
well as older diabetes drugs, but with fewer side effects like weight gain"
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