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Anti-aging Research > Procaine
Procaine HCI, Anticort, KH-3, GH-3
Note: I'm not a doctor but the way I
understand it, GH-3 (procaine HCl) reduces 3-hydroxy-3-methylglutaryl-coenzyme A
reductase (HMG-CoA) activity. This is what statins do to lower
cholesterol. Cortisol is made from cholesterol therefore less cholesterol
equals less cortisol. The company making Anticort (procaine HCl), stopped
after phase II studies. See
J Pharmacol Exp Ther. 2003 Dec;307(3):1148-57. Epub 2003 Oct 14. - Ben
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Specific Recommendations:
News & Research:
-
Inhibition of adrenal cortical steroid formation by procaine is mediated by
reduction of the cAMP-induced 3-hydroxy-3-methylglutaryl-coenzyme A
reductase messenger ribonucleic acid levels - J Pharmacol Exp Ther. 2003
Dec;307(3):1148-57. Epub 2003 Oct 14
-
Inhibition of adrenal cortical steroid formation by procaine is mediated by
reduction of the cAMP-induced 3-hydroxy-3-methylglutaryl-coenzyme A
reductase messenger ribonucleic acid levels
- J Pharmacol Exp Ther. 2003 Dec;307(3):1148-57. Epub 2003 Oct 14
- Gerovital GH-3 information - International
Antiaging Systems - "It is also
known that Gerovital-H3 can help reduce cortisol levels, the hormone
responsible for stress and a rare hormone in that it is one of the few that
increases with age. It is believed that high-cortisol levels lead to
accelerated aging because cortisol “attacks” the hypothalamus, the area of
the brain that “controls” the endocrine system. Ironically cortisol may run
out-of-control due to its ability to damage the hypothalamus that controls
the adrenal glands that produce cortisol!"
- Procaine HCI - aidsmap.com, 6/28/01
- STGI Announces Anticort's FDA Phase I/II is Moving Forward
- aegis.com, 7/28/99 - "Procaine
(the active ingredient of Anticort(TM)) has been used
clinically for more than 40 years, primarily as the local
injectable anesthetic
Novocaine. Despite the
widespread use of procaine, reports of side effects have been rare, and are
usually associated with excessive dosage, rapid absorption or inadvertent
intravascular injection ... For the pharmacokinetics study, participants
will receive Anticort(TM)
at a single oral dose of 200 mg (cohort A), 400 mg (cohort B), 600 mg
(cohort C) or 800 mg (cohort D). For the 8-week continuous dosing study,
participants will receive 200 mg (1 pill per day; cohort A), 400 mg (1 pill
twice daily; cohort B), 600 mg (1 pill three times daily; cohort C) or 800
mg (2 pills twice daily; cohort D). To ensure the safety of each dose level,
these cohorts will be enrolled sequentially"
- Study
Supports Role Of Anticort In Treating Alzheimer's, HIV - Doctor's Guide,
4/17/98 - "Cortisol's role as a
cause of disease is most recently confirmed in a study to be published in
the May issue of the journal Nature Neuroscience. Authored by Dr. Sonia
Lupien of McGill University, the study reports that high levels of cortisol
play a key role in Alzheimer's, memory loss, shrinkage of the brain and
aging. Dr. Lupien also states that such illnesses might be prevented with
medications to reduce elevated cortisol levels."
-
Georgetown Researchers Report Development of New Way to Control Excess
Cortisol Levels - Georgetown University Medical Center, 6/12/00 -
"Although more work is needed to understand how Anticort
works, these results clearly indicate that we now have a powerful tool to
control the stress response and its detrimental effects on the body"
-
Why Are So Many Women Depressed? - Scientific America Women's Health: A
Life Long Guide, Summer 1998 (see the subtopic "Stress and Cortisol") -
"It is unclear whether depression is a cause or a consequence of elevated
cortisol levels, but the two are undoubtedly related."
- Gerovital-H3, its regenerative effects - IAS
-
Top Ten
Life Extension Drugs - Life Extension Magazine, 9/95 (see number six on
GH-3/KH-3)
-
Anti-Cortisols May Offer New Hope For Retinitis Pigmentosa - Doctor's
Guide, 11/17/97 - "According to Sapse, RP can be treated initially with a cocktail of anti-cortisol
nutritional compounds including vitamin A, zinc, ginkgo biloba and
acetyl-L-carnitine . . ."
- Anticort
Aids Treatment - Doctor's Guide, 2/11/97 -
"ANTICORT (procaine HCI)"
- Findings Show
Cortisol's Major Role in AIDS and Other Diseases -
Doctor's Guide, 6/21/96 - "Anticort,
(to lower cortisol) a high dose form of stabilized procaine HCL, is being
successfully tested in pilot clinical studies in Brazil and the U.S., in
HIV+ and AIDS populations ... Researchers have already started to explore
the therapeutic benefits of such an approach through the use of
anti-cortisol drugs, such as
RU-486, DHEA,
Ketaconazole, Anticort and Tianeptine"
- Note that procaine HCL is the active ingredient in GH-3 and KH-3.
- Findings Show
Cortisol's Major Role in AIDS and Other Diseases - Doctor's Guide,
6/21/96 - "Anticort, a high dose
form of stabilized procaine HCL, is being successfully tested in pilot
clinical studies in Brazil and the U.S., in HIV+ and AIDS populations."
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