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Home > Anti-aging Research > RU-486
RU-486 (mifepristone)
- Abortion
drug may thwart breast cancer - MSNBC, 11/30/06
-
Two more women die after using the RU-486 - USA Today, 3/17/06
-
Abortion Drug Adverse Events Reported - WebMD, 12/29/05
-
First Analysis of FDA's Mifepristone Adverse Event Reports - Doctor's
Guide, 12/29/05
-
First Analysis Of FDA's Mifepristone Adverse Event Reports - Science
Daily, 12/28/05
- Abortion pill
maker alerts doctors to 5 deaths - MSNBC, 7/18/05
- Mifepristone May Be as Effective as Levonorgestrel for Emergency Contraception - Medscape, 12/15/04
- FDA: Abortion Pill Safe Enough For Sale - Intelihealth, 11/17/04
- Government Issues New RU-486 Warnings - WebMD, 11/16/04
- FDA Announces Important Labeling Changes for Mifepristone - Doctor's Guide, 11/16/04
- Mifeprex May Be Associated With Risk of Serious Complications, Death - Medscape, 11/16/04
- More Safety Warnings For Abortion Pill - Intelihealth, 11/16/04
-
Mifepristone May Ease Psychotic Depression - Clinical Psychiatry News, 6/04
- Low-Dose Mifepristone Shrinks Fibroids, Curbs Symptoms - Doctor's Guide, 4/2/03
- "Abortion Pill" Shrinks Fibroids - WebMD, 2/4/03
- Mifepristone A Promising Estrogen-Free Contraceptive - Doctor's Guide, 1/28/03
-
More Office-Based Physicians Offering Mifepristone - Clinical Psychiatry News, 11/02
- Short Term Mifepristone Effective For Psychotic Major Depression - Doctor's Guide, 10/22/02
-
Mifepristone Shows Promise for Psychotic Depression - Clinical Psychiatry News, 7/02
- Mifepristone Suppresses Ovulation and Menstruation - Doctor's Guide, 1/30/02
- RU-486 May Have Birth Control Potential - WebMD, 2/4/02
-
Researchers Explore New Meds for Mood Disorders - Clinical Psychiatry News, 10/01 -
"Another approach being developed for
patients with high levels of circulating cortisol involves the abortion pill mifepristone ... The findings, to be published this month in the Journal of Clinical Psychopharmacology, suggest that a rapid antidepressant response (approximately 7 days) may occur in some patients"
-
Researchers Hopeful Antidepressant Augmentation Will Improve Remission - Clinical Psychiatry News, 9/01 -
"In psychotic
depression, a corticosteroid antagonist looks most promising. Mifepristone, which is used to induce abortions but was originally designed as treatment for Cushing's disease, has achieved rapid reversal
of symptoms in some 30 psychotically depressed patients, ostensibly by blocking cortisol receptors. The drug is now being investigated in a large double-blind trial, he said"
- Abortion pill prescribed by relatively few doctors - USA Today, 10/1/01
- Abortion pill available to U.S. women as soon as Tuesday - CNN, 11/20/00
- RU-486 could aid variety of ills - MSNBC, 11/2/00 -
"RU-486’s ability to block the action of a different hormone — cortisol — has prompted doctors to try it for psychotic depression. In addition to feeling sad and worthless, people with this devastating condition
have distorted thinking and often suffer delusions or hallucinations. Many
become suicidal.
“They have very, very disturbing and crazy thoughts ... and they have no ability to suppress them,” said Joseph K. Belanoff, a California psychiatrist who is chief executive officer of Corcept Therapeutics Inc., a small pharmaceutical company. Corcept is sponsoring a study of RU-486 for psychotic depression.
Several lines of evidence have led researchers to suspect that some of the symptoms of psychotic depression are caused by an excess of cortisol in the brain. Cortisol levels rise in response to stress and may be abnormally elevated in depressed individuals. Similar symptoms can occur in patients with Cushing’s
syndrome, an overabundance of cortisol usually caused by a tumor, and RU-486 has cured the mental disturbance in some
such cases.
“Our feeling has been that a lot of the cognitive problems and delusions that you see in some of the patients are due to the [cortisol],” said Alan F. Schatzberg, chairman of the psychiatry department at Stanford University School of Medicine, where researchers are conducting a study that will test RU-486 on 30
patients with psychotic depression.
RU-486 or other cortisol-blocking drugs “may be better alternatives than ... some of the typical treatments” such as antipsychotic drugs or electric shock therapy, he said."
- Findings Show Cortisol's Major Role in AIDS and Other Diseases - Doctor's Guide, 6/21/96 -
"Researchers have already started to explore the therapeutic benefits of such an approach through the use of anti-cortisol drugs, such as RU-486, DHEA, Ketaconazole, Anticort and Tianeptine."
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