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Home > Anti-aging Research > Antidepressants > Clozaril (clozapine)
Clozaril (clozapine)
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News & Research:
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Clozaril (clozapine) - rxlist.com
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Comparison Of Antipsychotic Treatments In Adolescents With Schizophrenia
- Science Daily, 2/28/08 - "The researchers
discovered that clozapine was approximately twice as likely to produce a
treatment response as olanzapine"
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Using Clozapine in Agitated Dementia Patients - Clinical Psychiatry
News, 11/07
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Most
Effective Antipsychotic Drug Has Serious Health Consequences - Science
Daily, 7/16/06
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Schizophrenia drug 'health risk' - BBC News, 7/1/06
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Ziprasidone as Effective as Clozapine in Study of Difficult-to-Treat
Patients With Schizophrenia - Doctor's Guide, 5/30/06
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Comparative Efficacy and Safety of Ziprasidone and Clozapine in
Treatment-Refractory Schizophrenia - Doctor's Guide, 5/26/06
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FDA Approves Two Monitoring Changes For Clozapine Patients - Clinical
Psychiatry News, 10/05
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Two Atypical Anti-psychotic Drugs May Be Associated With An Increased Risk Of Diabetes For Patients With Schizophrenia - Science Daily, 1/5/05
- Clozapine, Olanzapine May be Associated with Increased Risk of Diabetes for Patients with Schizophrenia - Doctor's Guide, 1/3/05
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Reducing Clozapine's Metabolic Side Effects - Clinical Psychiatry News, 11/04
- Some Anti-Psychotic Medications May Trigger Diabetes - Science Daily, 10/8/04 -
"The rate is five to 10 times higher than the estimated rate of 6.3 cases per
1,000 in the general U.S. population"
- FazaClo (Clozapine) Orally Disintegrating Tablets Available in US for Patients Unresponsive to Standard Schizophrenia Treatments - Doctor's Guide, 7/21/04
- Clozapine Effective in Drug-Induced Psychosis in Parkinson's Disease - Medscape, 5/14/04
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Clozapine Still Stands Out in Schizophrenia Tx - Clinical Psychiatry News, 5/04
- Mirtazapine Plus Clozapine Appears to Improve Negative Symptoms of Schizophrenia - Doctor's Guide, 4/21/04
- Clozapine Associated With Risk of Hyperglycemia and Diabetes - Medscape, 4/8/04
- Clozapine May Impair Glucose Control in Patients With Schizophrenia - Doctor's Guide, 3/2/04
- Clozapine May Improve Levodopa-Induced Dyskinesias in Parkinson's Disease - Doctor's Guide, 2/12/04
- Clozapine Effective for Controlling Dyskinesias in People with Severe Parkinson's - Doctor's Guide, 2/10/04
- Clozapine Treatment Difficult to Maintain Long Term But Highly Effective When Maintained - Doctor's Guide, 11/3/03
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Antipsychotic-Induced Metabolic Syndrome Proves Costly - Clinical Psychiatry News, 9/03
- Case Study Highlights Risk of Dilated Cardiomyopathy with Clozapine Use - Doctor's Guide, 9/10/03
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Fewer WBC Checks Urged in Clozapine Cases - Clinical Psychiatry News, 7/03
- Schizophrenia Drugs Linked to Diabetes - WebMD, 6/3/03 -
"close to 25% of them developed high blood sugar levels while taking Clozaril, the first of these newer schizophrenia
medications -- called "atypical antipsychotics." ... people with schizophrenia have a four- to six-fold risk of diabetes compared with the general population ... One possible explanation: Those with
schizophrenia typically have higher levels of cortisol, known as the "stress hormone," because the body releases it during times of agitation. And high cortisol levels can cause problems in the way blood sugar is metabolized" - See my cortisol page
for possible ways to reduce it.
- Patients Can Switch Safely from Clozaril to Generic Clozapine - Doctor's Guide, 5/22/03
- Antipsychotics Effective for Elderly Patients With Dementia - Psychiatric News, 4/18/03 -
"atypical antipsychotics have been
used to alleviate deteriorating behavioral symptoms in dementia patients, such as agitation and aggression. New research that she cited shows some atypical antipsychotics can actually improve cognition through activating
the release of acetylcholine in the cortex. Clozapine, olanzapine, and risperidone, she reported, robustly increased acetylcholine release in the cortex, while ziprasidone only moderately increased
levels, compared with haloperidol and thioridazine, which did not elevate acetylcholine levels at all ... atypical antipsychotics
increase cortical dopamine and cholinesterase inhibitors at the very least increase cortical acetylcholine action, leading to an improvement in memory and thinking, as well as improvement in psychosis and behavior"
- Antipsychotics and Glucose Dysregulation: Their Relationship to Treatment Decisions - Psychiatric Times, 3/03
- Smoking-Related Anti-psychotic Dose Adjustment Could Improve Response - Doctor's Guide, 3/10/03 -
"Clozapine was largely metabolised by the cytochrome P450 enzyme CYP1A2. Smoking powerfully induced this enzyme's activity"
- Antipsychotics Raise Glucose, Cholesterol Levels In Schizophrenics - Doctor's Guide, 2/25/03 -
"Clozapine, olanzapine and
haloperidol are associated with increased plasma glucose level, and clozapine and olanzapine with raised cholesterol"
- Clozapine Monitoring Recommended In Schizophrenia Maintenance Therapy - Doctor's Guide, 2/17/03
- Clozapine Appears Better Therapy For Patients With Parkinson's Disease And Psychosis - Doctor's Guide, 2/17/03
- Clozapine Reduces Suicide Attempts in Schizophrenic Patients - Medscape, 1/16/03
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Clozapine Can Reduce Suicide Risk, FDA Says - Clinical Psychiatry News, 1/03
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Some Antipsychotics May Be Tied To Increased Type 2 Diabetes Risk - Clinical Psychiatry News, 1/03 -
"the risk was increased by 3.1 among those on olanzapine (Zyprexa), 7.44 times among those on clozapine, 2.13 among those on high-potency conventional antipsychotics such as haloperidol and fluphenazine, and by 3.46 times among those on low-potency conventional antipsychotics such as chlorpromazine and thioridazine"
- Clozaril (Clozapine) Reduces Risk Of Suicidal Behavior Among Patients With Schizophrenia, Schizoaffective Disorder - Doctor's Guide, 1/14/03
- FDA Approves Clozaril (Clozapine) To Reduce The Risk Of Suicidal Behavior - Doctor's Guide, 12/19/02
- FDA Committee Recommends Approval for Clozaril to Treat Suicidal Behavior -- Drug Could Be First Ever With Indication - Doctor's Guide, 11/5/02
- Clozapine Reduces Suicidality in Schizophrenia - Doctor's Guide, 6/26/02
- Possible Genetic Linkage Cited in Antipsychotic Drug Weight Gain - Doctor's Guide, 6/13/02
- Quetiapine, Clozapine May Benefit Patients with Parkinson's Disease and Hallucinations - Doctor's Guide, 4/19/02
- Acute Tryptophan Depletion in Schizophrenic Patients Treated With Clozapine - Archives of General Psychiatry, 3/02
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New Clozapine Labeling Warns of Myocarditis Risk - Clinical Psychiatry News, 3/02
- Focus on Clozapine - Medscape, 2/02
- Significant Risk of Cardiovascular Toxicity Associated with Schizophrenia Drug Clozaril (Clozapine) - Doctor's Guide, 1/18/02
- Olanzapine's And Clozapine's Effect On Weight Gain Related To Insulin And Leptin - Doctor's Guide, 3/26/01 -
"the median insulin level was significantly higher in
olanzapine patients ... In the clozapine group, insulin levels were positively correlated to the drug serum concentration"
- Risperidone, Clozapine Seem Equally Effective In Refractory Schizophrenia - Doctor's Guide, 10/25/00
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