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Home > Anti-aging Research > Guggul

Guggul (Commiphora mukul)

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News & Research:

  • Guggulipid Use in Hyperlipidemia - Medscape, 9/1/05 - "Current data in the clinical literature do not support the claims of guggulipid's efficacy in the treatment of hyperlipidemia in a western population. Clinicians should advise their patients with hyperlipidemia to avoid the use of guggulipid"
  • Guggul for Hypercholesterolemia - Medscape, 6/7/05 - "Studies of the efficacy of guggul for hypercholesterolemia have produced conflicting results. Information currently available indicates that guggul may be effective for lowering total cholesterol and triglycerides in patients on a non-Western diet. The one study involving a typical American diet did not show any benefits; in fact, patients taking guggul had slight increases in LDL cholesterol"
  • Downside to Cholesterol-Cutting Herbal Drug - WebMD, 9/24/04 - "guggulsterone stimulates a cell's drug metabolism machinery -- enzymes that break down prescription medicines. This action of the herbal supplement would affect medications such as the AIDS drug AZT, anticancer agents, and cholesterol-lowering statins"
  • Guggulipid Does Not Reduce Cholesterol Levels - Healthwell Exchange Daily News, 9/25/03
  • Herbal Extract, Guggulipid, Does Not Effectively Treat Hypercholesterolaemia Among Western Population - Doctor's Guide, 8/13/03
  • Popular Herb Doesn't Help Bad Cholesterol - WebMD, 8/12/03 - "In this study, 103 men and women -- all with high cholesterol -- were separated into three groups. One group took three, 1,000 mg doses of guggulipid daily -- a standard dose; the second group got a 2,000 mg dose of guggulipid -- a high dose, and the third group got placebo pills ... Those taking the placebo had 5% lower LDL cholesterol, whereas the guggulipid group had higher LDL levels. Those taking the standard dose had 4% higher LDL levels, and the high-dose group had 5% higher LDLs"
  • Controlling Cholesterol Naturally - Natural Foods Merchandiser, 8/03
  • Ancient Folk Remedy [guggul] Points Toward Possible New Way To Control Cholesterol - Intelihealth, 5/2/02 - "The sap from a tree known in India as guggul contains a compound that blocks the action of a cell receptor, called FXR, that helps regulate the level of cholesterol in the body ... This mechanism is completely different from the action of statin drugs ... finding a new way to reduce cholesterol could be very important for patients who cannot tolerate the side effects that some people experience with statin drugs"
  • Natural Product Lowers Cholesterol - WebMD, 5/2/02
  • Clinical Research: Use of Guggul Extract for the Treatment of Hypercholesterolemia - Medscape, 4/02 - "treatment with Gugulipid did not reduce serum cholesterol, and may actually increase LDL"
  • Question regarding your new cholesterol-lowering supplement, Policosanol - Life Extension Magazine, 11/01 - "Studies show that niacin (B3) in doses of 1.5 grams to 3 grams lower triglycerides levels and raise HDL concentrations. Those who tolerated higher doses of niacin (nicotinic acid) showed even more improvement in lipid levels. Some people taking just 1000 mg of flush-free niacin see an elevation in beneficial HDL. Green tea also has been shown to elevate levels of HDL while lowering serum triglyceride levels. In the Journal of Molecular Cell Biochemistry, curcumin has been demonstrated, in vivo, to decrease triglycerides and increase HDL. In a study published in 1989 by the Journal of Associated Physicians-India, 125 patients receiving gugulipid showed a drop of 16.8% in triglycerides, and a 60% increase in HDL cholesterol within three to four weeks. Make sure you are taking at least six Mega EPA fish oil capsules daily, as low dose fish oil may not adequately suppress triglycerides. Finally, there are some lifestyle changes you may wish to consider. If you are overweight, weight loss would be recommended, as it would help to lower triglycerides and raise HDL. Also, try reducing carbohydrates, which can raise triglycerides"
  • Evaluation of the Antihyperlipidemic Properties of Dietary Supplements - Medscape, 4/1/01 - "After 24 weeks of gugulipid treatment, total cholesterol levels decreased by 25.2 mg/dl, compared with a 7.6 mg/dl increase in the placebo group (p<0.01). The LDL was 16.9 mg/dl lower and 4.0 mg/dl higher, respectively ... In addition, a significant reduction in triglycerides was seen in the gugulipid-treated arm compared with placebo (-18 vs +5.5 mg/dl"
  • Tropical Remedies - Nutrition Science News, 5/00