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Artichoke Extract & caffeoylquinic acid & chlorogenic acid

Related Topics:

• cholesterol / HDL cholesterol / homocysteine / inflammation / heart disease / strokes / red yeast rice / policosanol / guggul / pantethine / inositol hexanicotinate / triglycerides / statins / green tea / hesperidin / hypertension / trans fatty acids / omega-3

Specific Recommendations:

• Artichoke extract at Amazon.com

News & Research:

• Why Coffee May Reduce Diabetes Risk - WebMD, 1/13/12 - "The Chinese researchers looked at three major active compounds in coffee and their effect on stopping the toxic accumulation of the protein: ... Caffeine ... Caffeic acid or CA ... Chlorogenic acid or CGA ... All three had an effect. However, caffeic acid was best" - Note:  I've always thought that artichoke extract which is 6% chlorogenic acid would do the same thing:
  • Chlorogenic acid - Wikipedia, the free encyclopedia - "Chlorogenic acid is a hydroxycinnamic acid, a member of a family of naturally occurring organic compounds. These are esters of polyphenolic caffeic acid and cyclitol (-)-quinic acid"
• Java Reduces Type 2 Diabetes Risk - WebMD, 11/7/02 - "Caffeine is known to decrease the body's response to insulin. However, other ingredients found in coffee -- magnesium and chlorogenic acid -- may have beneficial effects ... researchers followed more than 17,000 Dutch adults. After several years of follow-up, those who drank seven or more cups a day were half as likely to develop type 2 diabetes compared with those who drank less than two cups a day ... The long-term effects of drinking too much caffeine are not known and other health issues could develop" - Note:  Chlorogenic acid is in artichoke extract.  If magnesium and chlorogenic acid are the reason for the 50% diabetes reduction, it would seem to be a better choice than drinking seven cups of coffee per day.  See artichoke extract at Amazon.com.
• Artichoke Leaf Extract May Provide Irritable Bowel Syndrome Relief - Doctor's Guide, 3/22/01 - "Investigators report that the IBS patients had significant reductions in the severity of their IBS symptoms. They also note that both patients and their doctors gave favourable evaluation of the overall effectiveness of the extract ... Furthermore, 96 percent of patients rated artichoke leaf extract as better than or equal to previous therapies administered for their symptoms ... Patients were found to tolerate the extract well"
• Can Cirrhosis be Prevented? - Nutrition Science News, 1/99 - "Artichoke (Cynara scolymus) leaves are another liver remedy. Recent animal tests show supplementation with artichoke prevented a liver toxin from causing oxidation, thus preventing glutathione destruction. The active compound, cynarin, is found in highest concentrations in the leaves. Chlorogenic acid and other antioxidants are also present"

Abstracts:

• Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res 2021 Sep 27 - "artichoke significantly reduced TG (weighed mean difference [WMD]: -17.01 mg/dl, 95% CI: -23.88, -10.13, p = .011), TC (WMD: -17.01 mg/dl, 95% CI: -23.88, -10.13, p < .001), and LDL-C (WMD: -17.48 mg/dl, 95%CI: -25.44, -9.53, p < .001). No significant effect of artichoke on HDL-C level was detected (WMD: 0.78 mg/dl, 95%CI: -0.93, 2.49, p = .371). Combining the two effect sizes revealed that artichoke juice supplementation significantly reduced TG (WMD: -3.34 mg/dl, 95%CI: -5.51, -1.17, p = .003), TC (WMD: -18.04 mg/dl, 95%CI: -20.30, -15.78, p < .001), LDL-C (WMD: -1.75 mg/dl, 95%CI: -3.02, -0.48, p = .007), and HDL-C levels (WMD: -4.21 mg/dl, 95%CI: -5.49, -2.93, p < .001). In conclusion, we found that artichoke supplementation may favor CVD prevention by acting in improving the lipid profile" - See artichoke extract at Amazon.com.
• The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial - Phytother Res 2021 Sep 17 - "Medicinal plants are widely used as a complementary therapy to treat complex diseases, such as nonalcoholic fatty liver disease (NAFLD). Therefore, this study was done to investigate the effect of co-administration of artichoke leaf extract supplement (ALES) with conventional medicines on patients with NAFLD ... In summary, the results of the present study showed that the concomitant use of ALES with metformin and vitamin E can have beneficial effects on amelioration of complications in patients with NAFLD" - See artichoke extract at Amazon.com, vitamin E at Amazon.com and iHerb and metformin at ReliableRX.
• The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis - Int J Clin Pract 2021 Aug 12;e14726 - "A systematic review and meta-analysis was conducted to summarise studies conducted on the effects of artichoke supplementation on liver enzymes ... Artichoke supplementation elicited significant reductions in liver enzymes, especially among patients with non-alcoholic fatty liver disease" - See artichoke extract at Amazon.com.
• Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats - Br J Nutr. 2014 Jun 26:1-9 - "We established for the first time the molecular mechanisms driving the beneficial effects of JA in the prevention of type 2 diabetes and non-alcoholic fatty liver disease. We propose that 10 % JA supplementation may be beneficial for the prevention of the onset of these diseases"
• The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials - J Hum Hypertens. 2014 Jun 19 - "Meta-analysis revealed a statistically significant reduction in systolic blood pressure in favour of CGA (mean difference (MD): -4.31 mm Hg; 95% confidence interval (CI): -5.60 to -3.01; I2=65%; P<0.00001). Meta-analysis also showed a significant reduction in diastolic blood pressure favouring CGA (MD: -3.68 mm Hg; 95% CI: -3.91 to -3.45; I2=97%; P<0.00001)" - See artichoke extract at Amazon.com and chlorogenic acid at Amazon.com.
• A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial - Int J Food Sci Nutr. 2013 Jul 2 -"To investigate the effect of a natural cholesterol-lowering supplement (NCLS) containing red yeast rice, policosanols and artichoke leaf extracts on blood lipid concentrations as well as on safety parameters when given over 16 weeks in 100 volunteers with untreated moderate hypercholesterolemia ... The NCLS was effective in reducing low-density lipoprotein cholesterol and apolipoprotein B100 in subjects with moderate hypercholesterolemia, without modifying safety parameters"
• Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial - Int J Food Sci Nutr. 2012 Jun 29 - "The aim of this study was to evaluate the effects of artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid pattern. A randomized, double-blind, placebo-controlled clinical trial was performed on 92 overweight subjects with primary mild hypercholesterolaemia for 8 weeks. Forty-six subjects were randomized to supplementation (age: 54.2 +/- 6.6 years, body mass index (BMI): 25.8 +/- 3.9 kg/m(2), male/female: 20/26) and 46 subjects to placebo (age: 53.8 +/- 9.0 years, BMI: 24.8 +/- 1.6 kg/m(2), male/female: 21/25). Verum supplementation was associated with a significant increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in mean change in HDL-cholesterol (HDL-C) (p = 0.004). A significantly decreased difference was also found for the mean change in total cholesterol (p = 0.033), low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL ratio (p < 0.001) and LDL/HDL ratio (p < 0.001), when verum and placebo treatment were compared. These results indicate that ALE could play a relevant role in the management of mild hypercholesterolaemia, favouring in particular the increase in HDL-C, besides decreasing total cholesterol and LDL-cholesterol"