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Anti-aging Research > Statins > Zocor
(simvastatin)
Zocor (simvastatin)
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Alternative News:
-
Simvastatin in the Treatment
of Colorectal Cancer: A Review - Evid Based Complement Alternat Med 2022 Jul
14 - "Simvastatin is a clinically commonly used
hyperlipidemia drug and exerts the effect of preventing cardiovascular diseases.
Recent studies have found that simvastatin has great potential in the treatment
of colorectal cancer, and a large number of clinical studies have used
simvastatin as an adjuvant drug to help treat metastatic colorectal cancer"
- See
simvastatin at ReliableRXPharmacy.
-
The effect of 8 weeks of
physical training on muscle performance and maximal fat oxidation rates in
patients treated with simvastatin and coenzyme Q10 supplementation - J
Physiol 2021 Dec 10 - "Simvastatins are prescribed for
treatment of elevated cholesterol, but they may negatively impact metabolism,
muscle performance and the response to training. Coenzyme Q10 (CoQ10)
supplementation may alleviate some of these effects ... simvastatin treatment
decreases plasma concentrations of total CoQ10, but this can be alleviated by
simultaneous supplementation with CoQ10" - See
ubiquinol products at Amazon.com.
-
L-Carnitine/Simvastatin Reduces Lipoprotein (a) Levels Compared with
Simvastatin Monotherapy: A Randomized Double-Blind
Placebo-Controlled Study - Lipids. 2016 Dec 2 -
"Subjects were randomly allocated to receive
L-carnitine 2 g/day plus simvastatin 20 mg /day (N = 29) or placebo
plus simvastatin 20 mg/day (N = 29) for a total of 12 weeks. Lp(a)
was significantly reduced in the L-carnitine/simvastatin group
[-19.4%, from 52 (20-171) to 42 (15-102) mg/dL; p = 0.01], but not
in the placebo/simvastatin group [-6.7%, from 56 (26-108) to 52
(27-93) mg/dL, p = NS versus baseline and p = 0.016 for the
comparison between groups]. Similar significant reductions in total
cholesterol, LDL-C, apolipoprotein (apo) B and TAG were observed in
both groups" - See
L-carnitine at Amazon.com
 .
-
Lowering Blood Cholesterol With Fish Oil And Red Yeast Rice Instead
Of Statins - Science Daily, 7/8/08 -
"The alternative treatment group participants received daily fish
oil and red yeast rice supplements ... The statin group participants
received 40 milligrams (mg) of Zocor (simvastatin) daily ... The
researchers noted that there was a reduction in LDL cholesterol
levels in both groups. The alternative treatment group experienced a
42.4 percent reduction, and the statin group experienced a 39.6
percent reduction. Members of the alternative therapy group also had
a substantial reduction in triglycerides, another form of fat found
in the blood, and lost more weight" - See
red yeast rice products at iHerb
and
Mega Twin EPA at Amazon.com.
News & Research:
-
Simvastatin Inhibits
Endometrial Cancer Malignant Behaviors by Suppressing RAS/Mitogen-Activated
Protein Kinase (MAPK) Pathway-Mediated Reactive Oxygen Species (ROS) and
Ferroptosis - Evid Based Complement Alternat Med 2022 Oct 14 -
"All in all, simvastatin reduces the RAS/MAPK signaling
pathway to inhibit Ishikawa cell proliferation, colony formation, and invasion,
and promote cell oxidation and ferroptosis. This paper demonstrates the
potential of simvastatin as a new anticancer drug for EC"
-
Simvastatin Improves Sexual
Health QoL in Older Men With ED - Medscape, 5/26/14 -
"Our secondary analysis has shown a significant
improvement in sexual health related quality of life, specifically in relation
to perception of control and emotional health in men with untreated ED given 40
mg simvastatin [Zocor] for six months"
-
Long-term use of statins reduces the risk of hospitalization for dementia
- Atherosclerosis. 2013 Oct;230(2):171-6 - "A
population-based, nested case-control study was carried out by including the
cohort of 152,729 patients from Lombardy (Italy) aged 40 years or older who
were newly treated with statins between 2003 and 2004. Cases were the 1380
patients who experienced hospitalization for dementia disease from initial
prescription until 2010 ... Compared with patients who had very short
statins coverage (less than 6 months), those on 7-24, 25-48, and >48 months
of coverage respectively had risk reductions of 15% (OR: 0.85; 95% CI: 0.74
to 0.98), 28% (OR: 0.72; 95% CI: 0.61 to 0.85), and 25% (OR: 0.75; 95% CI:
0.61 to 0.94). Simvastatin and atorvastatin were both associated with a
reduced risk of dementia, while no similar evidence was observed for
fluvastatin and pravastatin"
-
High
dose statins prevents dementia, study suggests - Science Daily, 8/31/13
- "the current study examined whether statin use was
associated with new diagnoses of dementia. The researchers used a random
sample of 1 million patients covered by Taiwan's National Health Insurance
... The adjusted hazard ratios (HRs) for dementia were significantly
inversely associated with increased daily or total equivalent statin dosage.
The HRs for the three tertiles of mean equivalent daily dosage (lowest to
highest) were 0.622, 0.697 and 0.419 vs control ... Patients who received
the highest total equivalent doses of statins had a 3-fold decrease in the
risk of developing dementia ... Almost all the statins (except lovastatin)
decreased the risk for new onset dementia when taken at higher daily doses.
A high mean daily dosage of lovastatin was positively associated with the
development of dementia, possibly because lovastatin is a lipophilic statin
while the anti-inflammatory cholesterol lowering effect of lovastatin is not
comparable to that of atorvastatin and simvastatin" - Note: The brand
names are Mevacor (lovastatin), Lipitor (atorvastatin calcium), Zocor
(simvastatin), etc.
-
Widely Used Cholesterol-lowering Drug May Prevent Progression Of Parkinson's
Disease - Science Daily, 11/9/09 - "Simvastatin,
a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease
from progressing further"
-
Statins Show Dramatic Drug And Cell Dependent Effects In The Brain -
Science Daily, 10/28/09 - "Besides their tremendous
value in treating high cholesterol and lowering the risk of heart disease,
statins have also been reported to potentially lower the risks of other
diseases, such as dementia ... statin drugs can have profoundly different
effects on brain cells -both beneficial and detrimental ... simvastatin
reduced the expression of the cholesterol transporter ABCA1 by approximately
80% in astrocytes, while pravastatin lowered expression by only around 50%.
Another interesting difference was that while both statins decreased
expression of the Tau protein -associated with Alzheimer's disease -- in
astrocytes, they increased Tau expression in neurons; pravastatin also
increased the expression of another Alzheimer's hallmark, amyloid precursor
protein (APP)"
-
FDA approves
combination niacin and simvastatin - theheart.org, 2/19/08 -
"The US Food and Drug Administration has approved a
fixed-dose combination of extended-release niacin (Niaspan, Abbot) and
simvastatin ... known as Simcor ... compared with simvastatin 20 mg, the
fixed-dose combination reduced triglyceride levels an additional 27%"
-
Cholesterol-lowering Drug Linked To Sleep Disruptions - Science Daily,
11/7/07 - "The results showed that simvastain use
was associated with significantly worse sleep quality. A significantly
greater number of individuals taking simvastatin reported sleep problems
than those taking either pravastain or the placebo"
-
Cholesterol Drug May Affect Sleep - WebMD, 11/7/07
-
Combination Niacin-Laropiprant Plus Simvastatin Reduces Cholesterol by
Almost 50% - Doctor's Guide, 11/6/07 - "When
patients with dyslipidemia added simvastatin to their experimental
combination of extended-release niacin and
laropiprant -- a novel anti-flushing agent -- they reported reductions in
low density lipoprotein cholesterol (LDL-C) of as much as 48% from baseline
... high density liopoprotein cholesterol (HDL-C) was increased by 28% and
triglycerides decreased by 33%"
-
Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's
Weekly Article, 10/15/07 - "there appears to be a
strong reduction in dementia and Parkinson’s disease incidence attributed to
the use of simvastatin, a cholesterol lowering drug. The researchers also
observed a moderate reduction in incidence of these conditions with
atorvastatin, another cholesterol-lowering drug"
-
Cholesterol Drug Change May Be Risky - WebMD, 9/5/07 -
"Compared with the patients who remained on Lipitor,
those who switched to simvastatin were 43% more likely to suffer from a
major cardiovascular event such as heart attack or stroke. They were twice
as likely to suffer strokes, and 36% more likely to have heart attacks"
-
Zocor vs. Alzheimer's and Parkinson's - WebMD, 7/18/07 -
"In patients over age 64, those who took Zocor were
54% less likely to get Alzheimer's disease and 49% less likely to get
Parkinson's disease than were matched patients not taking statin drugs ...
Those who took Lipitor were 9% less likely to get Alzheimer's disease"
-
Statin Treatment Improves Spatial Memory In Mouse Models Of Alzheimer's
- Science Daily, 4/30/07 -
"Treatment with Simvastatin, one of the statin drugs
widely used for lowering cholesterol in humans, significantly improved
spatial memory - how to navigate a water maze - in mice genetically bred to
have an Alzheimer's like disease"
-
Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High
Cardiovascular-Risk Patients With Elevated High Sensitivity C-Reactive
Protein: The PIOSTAT Study - Medscape, 1/9/07 -
"After 12 weeks of treatment, hs-CRP levels were
reduced from 3.64 +/-2.42 mg/l to 2.48 +/-1.77 mg/l with pioglitazone
monotherapy and from 3.26 +/-2.02 mg/l to 2.81 +/-2.11 mg/l with simvastatin
monotherapy (as illustrated in Fig. 1). Combination treatment with
pioglitazone and simvastatin resulted in an additive decrease in hs-CRP
levels from 3.49 +/-1.97 mg/l to 2.06 +/-1.42 mg/l after 12 weeks"
-
Simvastatin May Cut Alzheimer's, Parkinson's Risk - Clinical Psychiatry
News, 12/06 - "Simvastatin use for at least 7 months
reduced the incidence of Alzheimer's disease by 30% and Parkinson's disease
by 24% in older people ... Neither lovastatin nor atorvastatin provided
similar benefits"
-
Researchers Find Added Benefit of Statins in Those at High Risk for Heart
Disease, Diabetes - Doctor's Guide, 9/13/06 -
"found marked reductions in two pivotal biomarkers
of inflammation: C-reactive protein (CRP) and interleukin-6. While these
markers are typically elevated in insulin resistance, a condition that
precedes the development of diabetes, statin therapy reduced these levels by
36% and 44%, respectively"
-
Atorvastatin More Effective Than Simvastatin in Cutting Risk of Additional
Heart Attacks in Patients Who Had a Recent Heart Attack, New Data Suggests
- Doctor's Guide, 9/6/06
-
FDA OKs 1st Generic Version of Zocor - WebMD, 6/23/06 -
"The first generic version of the
cholesterol-lowering statin drug Zocor has been approved by the FDA"
-
Erectile Dysfunction and Statin Treatment - Medscape, 3/21/06 -
"Simvastatin was found to cause impotency in five
men with coronary artery disease, and within 1 week of discontinuing
simvastatin, sexual function was restored. The Australian Adverse Drug
Reactions Committee reported 42 cases of ED associated with simvastatin.[13]
In contrast, in one study in men aged 49.7 years and isolated
hypercholesterolaemia [low-density lipoprotein (LDL)-C 4.3 mmol/l] as a risk
factor which used penile Doppler ultrasound in a per protocol analysis of
50% of the cohort of 18 patients (n = 9), atorvastatin therapy was
associated with improvement in erectile function"
-
Simvastatin and Depression - Medscape, 1/20/06
-
Simvastatin Improves Metabolic Profile and Clinical Symptoms Associated with
Polycystic Ovary Syndrome - Doctor's Guide, 10/20/05
-
Rhabdomyolysis from Simvastatin Triggered by Infection - Medscape,
9/8/05
-
MRI Scan Reveals How Cholesterol Drugs Work - WebMD, 7/5/05 -
"20 milligrams or 80 milligrams of Zocor daily ...
After a year and a half of treatment, MRI scans showed that both groups
ended up with similar reductions in plaque size, regardless of the strength
of their statin dose ... Reduction in the size of blood vessel wall plaque
was greater in people whose LDL cholesterol dropped below 100 mg/dl"
-
Statins Do More Than Lower Cholesterol - HealthDay, 4/2/05 -
"A new study in diabetic rats suggests that statin
treatment also prevents or reverses damage to the delicate endothelial cells
that line arteries"
-
Simvastatin Appears Safe and Effective for PCOS Patients - Medscape,
3/25/05
-
Vytorin Slashes Bad Cholesterol to Lower Levels Than Atorvastatin -
Doctor's Guide, 3/9/05
-
Cholesterol-lowering drugs have a long-term effect - US News, 12/3/04 -
"Patients who'd taken simvastatin during the
five-year trial were still better off five years after the trial ended. (In
this case, "better off" means "more likely to be alive.")"
-
Statins May Lower Blood Pressure - Doctor's Guide, 11/20/04 -
"simvastatin was associated with a 2.79-mm Hg
decrease in systolic blood pressure and a 2.67-mm Hg drop in diastolic blood
pressure, while pravastatin led to a 2.47-mm Hg decline in systolic blood
pressure and a 2.47-drop in diastolic blood pressure"
-
Simvastatin Demonstrates Benefits in Patients With Chronic Renal
Insufficiency - Doctor's Guide, 11/1/04
-
Simvastatin's Benefits May Extend to Atherosclerotic Plaque Stabilisation in
Diabetics - Doctor's Guide, 10/25/04 -
"Simvastatin-dependent plaque stabilisation in
patients with type 2 diabetes arises from the drug's ability to decrease
expression of receptor for
advanced glycation end products (RAGE), and thence to reduce
metalloproteinase (MMP) activity, and promote plaque stabilisation"
- Is Lower
Really Better for Cholesterol? - WebMD, 9/14/04 -
"The National Cholesterol Education Program (NCEP)
reduced target LDL levels from 100 mg/dL to 70 mg/dL for those at the very
highest risk of heart disease ... high-dose Lipitor decreased CRP by 38%,
while high-dose Zocor reduced CRP by just 17% in the current study"
-
Why Some Statins Work Better - Time Magazine, 9/13/04 -
"patients taking high doses of Zocor fared no better
than a low-dose group in terms of heart-attack risk, despite low LDL levels.
Why? Perhaps because Lipitor works not just by lowering cholesterol but also
by reducing inflammation, something Zocor can't do as well"
- Cholesterol
Drug Goes Over-the-Counter - WebMD, 7/29/04
- New
Cholesterol Drug Poised for U.S. Market - WebMD, 7/22/04 -
"The drug, called Vytorin, is the first of its kind,
combining a popular drug, Zocor, from a class known as statins, with a
non-statin medication, Zetia, in a single pill"
-
No Clear-Cut Answers on Statins as Therapy for Alzheimer's Disease -
Doctor's Guide, 7/19/04 -
"Alzheimer mice treated with simvastatin regain
their ability to navigate mazes"
-
Simvastatin and Niacin Well Tolerated in Patients With or Without Diabetes
- Doctor's Guide, 4/13/04
- Statins Effectively
Lower Cholesterol, But Experts Debate First Choice - Medscape, 3/15/04 -
"HDL cholesterol levels were increased more than 10%
with
rosuvastatin 40 mg, nearly 5% with
atorvastatin 80 mg, 10% with 40 mg simvastatin, and 6.4% with 40 mg
pravastatin"
- Lipid-Lowering
Combination May Be More Effective Than High-Dose Atorvastatin -
Medscape, 3/12/04 -
"The coadministration of
ezetimibe plus simvastatin provided additional improvements in lipid
profiles across a wide range of doses compared with titration of
atorvastatin monotherapy"
-
Simvastatin/Ezetimibe Combination Outperforms High Dose Atorvastatin in
Lowering Cholesterol - Doctor's Guide, 3/9/04
-
Ezetimibe Plus Simvastatin Reduces C-Reactive Protein Levels - Doctor's
Guide, 11/14/03
-
Zetia (Ezetimibe) Plus Simvastatin Provided More than Twice the Reduction of
C-reactive protein in Patients with High Cholesterol Compared to Simvastatin
Alone - Doctor's Guide, 11/13/03 - "CRP
is considered an emerging risk marker for CHD ...
Zetia with
simvastatin reduced levels of the marker CRP by 33.3 percent compared to
simvastatin administered alone (14.3 percent ... In addition, patients
taking Zetia co-administered with simvastatin experienced an LDL cholesterol
(LDL-C) reduction of 45 to 60 percent across the dosage range, compared to a
reduction of 31 to 44 percent in patients taking simvastatin alone"
-
Intravascular Ultrasound Depicts Coronary Artery Plaque Regression With
Simvastatin - Doctor's Guide, 11/12/03 -
"Lipid-lowering therapy with simvastatin for 12
months is associated with a significant plaque regression ... the plaque
regression -- about 6.3% from baseline"
-
Simvastatin Increases HDL-C And Apo A-I More Than Atorvastatin in Patients
With Hypercholesterolemia - Doctor's Guide, 11/10/03 -
"Simvastatin appears to increase high-density
lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I significantly
more than does atorvastatin in
patients with hypercholesterolaemia ... Liver toxicity occurred in
significantly fewer patients treated with simvastatin compared to
atorvastatin"
-
Combination Treatment of Ezetimibe and Simvastatin Safe and Effective -
Doctor's Guide, 10/3/03 -
"The combined administration of ezetimibe 10 mg/dL
and simvastatin 5 mg to 80 mg/dL is well tolerated and effective in allowing
patients with primary hypercholesterolaemia to attain the recommended
low-density lipoprotein (LDL) cholesterol levels ... ezetimibe is a
cholesterol absorption inhibitor that blocks the transport of dietary
and biliary cholesterol across the intestinal wall"
-
Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
"Rosuvastatin
significantly more effective than
atorvastatin, simvastatin, and
pravastatin in improving the ratios of total cholesterol to high-density
lipoprotein cholesterol" - See
Crestor (rosuvastatin)
at drugstore.com.
-
Statins Used to Treat High Cholesterol and Osteoporosis - Doctor's
Guide, 9/30/03 -
"simvastatin acts as a double therapeutic weapon by
blocking the conversion of HMG-CoA to mevalonate. Not only does this action
increase new bone formation via the stimulation of osteoblasts, but it also
prevents the production of cholesterol" - See
Zocor (simvastatin)
at drugstore.com.
-
Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol
- Doctor's Guide, 9/30/03 -
"Most significantly, while the PWV remained
unchanged in the pravastatin and non-statin group, it was moderately
decreased in the simvastatin group and remarkably reduced in the fluvastatin
group ... Dr. Ichihara theorized that lipophilic statins, such as
fluvastatin, reduce aortic
stiffness via three mechanisms -- decreasing serum total cholesterol
levels without reducing serum high-density lipoprotein levels, providing
powerful scavenging reactive oxygen species, as well as reducing serum
levels of low-density lipoprotein and C-reactive protein" - See
Zocor (simvastatin),
Pravachol (pravastatin)
and
Lescol (fluvastatin)
at drugstore.com.
-
Statins may play a role in the treatment of inflammatory rheumatic diseases
- Doctor's Guide, 9/28/03 -
"the administration of simvastatin for 8 days was
associated with a rapid and significant reduction in proteinuria levels in
the three patients with SLE, as well as in
the 2 patients with systemic vasculitis. In the five patients with
RA, atorvastatin for 8 days was associated with a reduction in
C-reactive protein levels and clinical improvement ... statins may have
an important therapeutic potential for different inflammatory diseases"
-
Heart Protection Study Implications for Lipid Management Guidelines and
Practices - Doctor's Guide, 9/16/03 -
"While Heart Protection Study (HPS) findings support
aggressive lowering of low-density lipoprotein (LDL) cholesterol levels and
suggest optimal levels well below current recommendations, failure to
achieve current goals for LDL cholesterol is common ... HPS findings
demonstrated that a reduction of major vascular events extended even to CAD
patients with initial LDL cholesterol levels <100 mg/dL using simvastatin 40
mg, suggesting that the optimal LDL cholesterol level is below target levels
established in current guidelines ... rosuvastatin is more effective than
other statins in reducing LDL cholesterol"
- Statins Benefit
Diabetics, Regardless of Cholesterol Levels - Medscape, 8/13/03 -
"These results show that simvastatin therapy leads
to significant risk reductions for vascular events in type 2 diabetic
patients, even if they don't have diagnosed coronary disease or high
cholesterol levels. The authors estimate that 5 years of treatment would
prevent about 45 major vascular events per 1000 patients and suggest that
statins should be offered to high-risk diabetic patients regardless of their
cholesterol levels"
- Statins Help
Ease Heart Failure - WebMD, 7/28/03 -
"People with heart failure may benefit from
treatment with cholesterol-lowering statin drugs even if their cholesterol
levels are normal ... One group took 5 mg of the statin Zocor for four weeks
followed by 10 mg for 10 weeks ... standard dose of Zocor in the U.S. to
treat high cholesterol is 40 mg ... researchers found significant
improvements among the patients taking the statin. Their average level of
functional heart impairment dropped from 2.39 to 2.04 on a scale of 1 to 4
... left ventricular ejection fraction, a measure of heart function, rose
from 34% to 41%"
-
Simvastatin May Retard Progression of Severe White Matter Changes -
Doctor's Guide, 5/26/03 -
"Simvastatin may slow down the progression of severe
white matter changes in the brain, and may therefore retard
cognitive decline ... The most common type of vascular dementia is due
to the hardening of the arteries
deep inside the brain which causes white matter changes... and its been
shown that this can lead to executive dysfunction"
-
Simvastatin Therapy Slows Coronary Disease Progression in Patients With and
Without Cardiovascular Risk Factors - Doctor's Guide, 5/22/03 -
"simvastatin/enalapril
therapy versus placebo resulted in decreases in mean coronary artery
diameters ... and minimum diameters ... study results support the contention
that the therapeutic effect of statin lipid lowering drugs on
angiographically seen coronary atherosclerosis is linked to the reduction of
coronary events without regard to the presence of known cardiovascular risk
factors"
-
Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High
Cholesterol - Doctor's Guide, 4/4/03 -
"C-reactive
protein is considered an emerging risk factor and risk marker for
coronary heart disease ... the levels of C-reactive protein were about
halved when the pooled
ezetimibe plus simvastatin results were compared with simvastatin alone.
The combination produced about a 34.8% reduction compared to an 18.2%
reduction if the statin was used as monotherapy"
- Statin Appears
Promising for MS - Medscape, 4/2/03
- Zocor for
Multiple Sclerosis Treatment - WebMD, 4/2/03
-
Ezetimibe Plus Simvastatin Safely Improves Lipid Profile - Doctor's
Guide, 1/17/03 -
"Ezetimibe and simvastatin given together reduced
low-density lipoprotein cholesterol
by 44 to 57%, reduced triglycerides
by 20 to 28% and raised high-density lipoprotein
cholesterol by 8 to 11%, depending on the simvastatin dose"
-
Atorvastatin, Simvastatin Effects Similar For Subclinical Atherosclerosis
- Doctor's Guide, 1/7/03
-
Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For
Hyperlipidemia - Doctor's Guide, 12/24/02 -
"One group received 3.5 grams of
ispaghula husk
twice a day and the second group received 20 milligrams of simvastatin each
day ... total
cholesterol decreased by 15.8 percent and low-density lipoprotein (LDL)
cholesterol decreased by 22.97 percent among patients taking ispaghula husk
... Triglycerides
decreased by 20.89 percent and
high-density lipoprotein (HDL) cholesterol increased by 10.69 percent in
these patients ... Among patients taking simvastatin, total cholesterol
decreased by 24.15 percent, LDL cholesterol decreased by 36.08 percent,
triglycerides decreased by 20.47 percent and HDL cholesterol increased by
11.4 percent" - I've got that. See
Drugstore.com psyllium products
 .
3.5 grams is about one wafer (3.4 grams psyllium/wafer). Plus 24 wafers
runs about
$4.49
versus about
$116
for 30 of the 20 mg simvastatin.
-
Simvastatin Increases HDL and Apo-A1 Better Than Atorvastatin - Doctor's
Guide, 9/13/02
-
Early Simvastatin Therapy Improves Endothelial Function - Doctor's
Guide, 9/13/02
-
Simvastatin Protects against Endothelial Dysfunction in Type 2 Diabetes
- Doctor's Guide, 9/5/02
-
Simvastatin Improves Cholesterol Profile more than Atorvastatin in the
Metabolic Syndrome - Doctor's Guide, 9/4/02
-
Zocor (Simvastatin) Saves Lives In High-Risk Patients, Regardless Of
Cholesterol Level, Study In Lancet Shows - Diabetics, Women, Elderly Benefit
In Largest Cholesterol Study Ever - Doctor's Guide, 7/5/02 -
"simvastatin given daily at 40 mg reduced the risk of
heart attack and stroke by about
one-fourth over the treatment period, which averaged 5.3 years ... When
adjusted for non-compliance (inadvertent or deliberate failure to take
medication) in the trial, investigators estimate that the risk reduction
among this broad population is one-third ... Not only did we find that
cholesterol-lowering treatment can protect a far wider range of people than
was previously thought, but that the therapy we used in the study can
prevent stroke as well as heart attack, in patients at risk of CHD even in
people with already moderate or low cholesterol levels ... Patients with
average or low cholesterol levels also achieved CHD risk reductions of about
a quarter. When adjusted for non-compliance, Oxford researchers estimate
that the risk of heart attack and stroke in this group would be reduced by
one-third"
- WelChol (colesevelam
HCl)/Zocor (simvastatin) Combo Better Than Zocor Alone - Doctor's Guide,
4/30/01 -
"Treatment with WelChol (3.8 grams daily) decreased
LDL-cholesterol levels by 16 percent, and Zocor (10 milligrams daily)
reduced mean LDL-cholesterol levels by 26 percent; the combination appeared
to be additive, with a 42 percent reduction"
- Atorvastatin Better than
Simvastatin for Achieving Total Cholesterol Targets - Doctor's Guide,
4/12/00
- Zocor (Simvastatin)
Increases HDL And apo A-I More Than Lipitor (Atorvastatin) - Doctor's
Guide, 3/15/00
- Study Shows Significant
Difference Between Two Statins In Raising HDL - Doctor's Guide, 8/25/98
Abstracts:
-
Metformin and simvastatin
exert additive antitumour effects in glioblastoma via senescence-state: clinical
and translational evidence - EBioMedicine 2023 Mar 10 -
"Glioblastoma is one of the most devastating and
incurable cancers due to its aggressive behaviour and lack of available
therapies, being its overall-survival from diagnosis ∼14-months. Thus,
identification of new therapeutic tools is urgently needed. Interestingly,
metabolism-related drugs (e.g., metformin/statins) are emerging as efficient
antitumour agents for several cancers ... Altogether, metformin and simvastatin
reduce aggressiveness features in glioblastomas, being this effect significantly
more effective (in vitro/in vivo) when both drugs are combined, offering a
clinically relevant opportunity that should be tested for their use in humans"
- See
metformin at ReliableRX and
simvastatin at ReliableRXPharmacy.
-
Can simvastatin
improve erectile function and health-related quality of life in men aged ≥40
years with erectile dysfunction? Results of the Erectile Dysfunction and
Statins Trial - BJU Int. 2012 Jun 11 - "Erectile
dysfunction (ED) is often associated with endothelial dysfunction. It is
also recognized as a marker for underlying vascular disease. There are
missed opportunities to address cardiovascular risk factors in these men.
Simvastatin administered for 6 months improves sexual health-related quality
of life in men aged ≥40 years with untreated ED. It reduces the risk of
future cardiovascular events via a reduction in serum cholesterol in men
with ED. A non-significant trend towards improving erectile function
suggests longer trials with a more potent statin may be required ... joint
analysis of costs and QALY benefits suggests that there is high probability
that simvastatin is a cost-effective strategy in men with ED"
-
The
effect of simvastatin in penile erection: a randomized, double-blind,
placebo-controlled clinical trial (Simvastatin treatment for erectile
dysfunction-STED TRIAL) - Int J Impot Res. 2011 Jun 30
-
Use of
high-intensity statin therapy with simvastatin 80 mg and atorvastatin 80 mg
in primary care - Int J Clin Pract. 2011 Feb;65(2):120-6 -
"The present study suggests that atorvastatin 80 mg
compares favourably to simvastatin in terms of efficacy and has a similar
tolerability profile. Conclusion: This retrospective observational study
suggests that despite national guidelines, atorvastatin 80 mg is used in
clinical practice and is more effective and at least as well tolerated as
simvastatin 80 mg"
-
Simvastatin induces apoptosis in human colon cancer cells and in tumor
xenografts, and attenuates colitis-associated colon cancer in mice - Int
J Cancer. 2008 Jun 2 - "colitis-associated colon
cancer (CAC) ... simvastatin could be a potential chemopreventive and
therapeutic agent of CAC as well as de novo colon cancer"
-
Comparison of the Safety and Efficacy of a Combination Tablet of Niacin
Extended Release and Simvastatin vs Simvastatin Monotherapy in Patients With
Increased Non-HDL Cholesterol (from the SEACOAST I Study) - Am J
Cardiol. 2008 May 15;101(10):1428-36 - "The efficacy
and safety of 2 regimens of a combination of a proprietary niacin extended
release plus simvastatin (NER/S; 1,000/20 and 2,000/20 mg/day) were compared
with simvastatin monotherapy (20 mg/day) for 24 weeks ... The safety of
NER/S was consistent with the safety profile of each individual component.
In conclusion, this study showed that NER/S provided additional clinically
relevant improvements in multiple lipid parameters and was safe and well
tolerated"
-
High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention
After Myocardial Infarction - JAMA. 2005;294:2437-2445
-
Effectiveness of simvastatin therapy in raising HDL-C in patients with type
2 diabetes and low HDL-C - Curr Med Res Opin. 2004 Jul;20(7):1087-94 -
"Both simvastatin 80 and 40 mg significantly increased total HDL-C from
baseline (mean increases of 8%"
-
Simvastatin and impotence - BMJ 1997;315:31 (5 July)
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