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Home > Anti-aging Research > Antidepressants & Psychotropics > Anafranil

Anafranil® (clomipramine)

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Abstracts:

  • Which antidepressants have demonstrated superior efficacy? A review of the evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 - "Criteria were defined to judge the strength of evidence. Two pivotal studies in moderate-to-severe major depressive disorder that demonstrate superiority on the primary efficacy measure, or alternatively one pivotal study supported by consistent results from meta-analyses, was considered to constitute evidence for definite superiority. Three antidepressants met these criteria: clomipramine, venlafaxine, and escitalopram. Three antidepressants were found to have probable superiority: milnacipran, duloxetine, and mirtazapine. Only escitalopram was found to have definite superiority in the treatment of severe depression; probable superiority was identified for venlafaxine and possible superiority for milnacipran and clomipra"

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