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Home > Anti-aging Research > Peroxisome Proliferator-activated Receptors

Peroxisome Proliferator-activated Receptors (PPARs))

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News & Research:

• Molecular 'switch' contributes to cellular aging process: Discovery suggests new treatments for metabolic diseases - Science Daily, 11/30/10 - "in older animals SMRT acts like a "switch," turning off the protective cellular activities of proteins known as peroxisome proliferator-activated receptors (PPARs). PPARs help regulate genes that promote fat burning to maintain lipid (blood fat) balance and reduce oxidative stress. The researchers were able to reduce the negative effects of oxidative stress by giving antioxidants or drugs known to turn the protective activities of PPARs back on ... PPAR drugs have been used to increase insulin sensitivity and lower blood lipid levels ... we believe SMRT is one of the key players that causes age-dependent decline in mitochondrial function by blocking PPAR activity, and we've found a way to boost the body's ability to better handle metabolic and oxidative stress" - Note: There are several PARR receptor activators such as the blood pressure drug telmisartan and the diabetes medication Actos (some doctors have criticized me for years for taking it for anti-aging).  When I get a chance I'll search my site and put the articles on it.