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Home > Anti-aging Research > GABA
GABA (Gamma-aminobutyric acid)
Specific Recommendations:
CME:
- The Role of GABA in the Pathogenesis and Treatement of Aniety and other Neurophychiatric Disorders - vcu-cme.org, exp. -
"The cliché “If you find one thing wrong in the brain, you’ll
find more than one” clearly applies to psychiatric disorders. Most individuals with psychiatric disorders suffer from one or more additional disorders at some point, and it is not surprising that many patients require multipledrug
therapy to control their symptoms. Unfortunately, many individuals with comorbid psychiatric disorders fail to respond optimally to treatment. It is likely that specific GABA-enhancing
agents will play important roles as treatment for patients with anxiety disorders, with or without comorbidity, and as adjunctive therapy in patients with more complicated
neuropsychiatric disorders."
News & Research:
-
Early
research shows dietary supplement may lower risk of developing type 2 diabetes
- Science Daily, 9/22/11 - "a naturally produced amino acid-like molecule called
GABA was given orally to mice that were obese, insulin resistant and in the
early stages of Type 2 diabetes. Researchers found that GABA suppressed the
inflammatory immune responses that are involved in the development of this
condition ... GABA helped prevent disease progression and improved glucose
tolerance and insulin sensitivity, even after onset of Type 2 diabetes in mice"
-
Mind-altering microbes: Probiotic bacteria may lessen anxiety and depression
- Science Daily, 8/29/11 - "Probiotic bacteria have the potential to alter brain
neurochemistry and treat anxiety and depression-related disorders ... mice fed
with Lactobacillus rhamnosus JB-1 showed significantly fewer stress, anxiety and
depression-related behaviours than those fed with just broth. Moreover,
ingestion of the bacteria resulted in significantly lower levels of the
stress-induced hormone, corticosterone ... regular feeding with the
Lactobacillus strain caused changes in the expression of receptors for the
neurotransmitter GABA in the mouse brain, which is the first time that it has
been demonstrated that potential probiotics have a direct effect on brain
chemistry in normal situations" - See
probiotic products at iHerb.
-
Scientists discover new role for vitamin C in the eye and the brain -
Science Daily, 7/15/11 - "cells in the retina need to be 'bathed' in relatively
high doses of vitamin C, inside and out, to function properly ... Because the
retina is part of the central nervous system, this suggests there's likely an
important role for vitamin C throughout our brains, to a degree we had not
realized before ... The findings could have implications for other diseases,
like glaucoma and epilepsy. Both conditions are caused by the dysfunction of
nerve cells in the retina and brain that become over excited in part because
GABA receptors may not be functioning properly" - See
vitamin C products at iHerb.
-
Trouble
with the latest dance move? GABA might be to blame - Science Daily, 3/3/11 -
"those who were more GABA responsive were also quicker
to learn the simple motor task. The brains of more GABA-responsive individuals
also showed greater activation in the motor cortex during learning. The
researchers also found that those with higher GABA concentrations at baseline
tended to have slower reaction times and less brain activation during learning
... GABA levels can change after that kind of brain trauma, and the findings
support the idea that treatments designed to influence GABA levels might improve
learning"
-
The Body Odd - Can't dance? Brain chemical throws off your groove - MSNBC,
3/3/11
-
Memory's
master switch: Molecular power behind memory discovered - Science Daily,
7/29/10 - "Higher concentrations of GABA near a synapse induced a stronger
activation of its receptors, weakening basal synapse strength. As a result, GABA
makes this synapse more liable to the formation of new memories"
-
Anxiety Protocol - Life Extension Magazine - "Theanine is an amino acid found in green tea and produces a calming effect
on the brain (Yokogoshi H et al 1998). It easily crosses the blood-brain
barrier and produces subtle changes in biochemistry, including increased
production of GABA and dopamine, which cause a tranquilizing effect"
- PharmaGABA:
Natural Support for Stress, Anxiety, and Insomnia - Dr. Murray's Natural
Living, 5/17/07
- Brown rice may act against onset of Alzheimer’s - Nutra USA, 5/25/04 -
"Pre-germinated brown rice, high in levels of the nutrient GABA, significantly improved
levels of spatial learning in mice"
- Sleep Problems, Anxiety May Be Connected - WebMD, 9/12/03 -
"both sleep and mood problems may result from a lack of
the same brain chemical ... The brain chemical -- gamma-aminobutryric acid, or GABA -- is involved in regulating brain activity ... Specifically, GABA deficiencies interfere with the most important stage of sleep -- the "deep" delta sleep" - See
iHerb
or Vitacost
GABA products.
- Study: GABA May Help Brain Aging - Physician's Weekly, 5/26/03
- GABA Makes Old Brains Act Young Again - WebMD, 5/2/03
- Chemical helps aging brains feel younger - MSNBC, 5/1/03 -
"in old primates, both human and monkey, there is a decline in the levels of GABA, a chemical that inhibits neuron signals in the brain. Without enough
of that control, he said, the brain is distracted and overwhelmed by stray signals, in the same way the ear is overwhelmed when trying to hear a whisper at a rock concert ... When minute quantities of GABA were injected directly into neurons, the brains of the older monkeys responded just like those of the young
animals ... Added GABA appeared to have no effect on the young"
-
Old Monkey Study Might Help Old Human Brains - HealthDay, 5/1/03 -
"brain cells in the old monkeys have lost much of their ability to respond to the specific signals carried by GABA. Giving GABA to
young monkeys did very little in terms of brain function, but it helped the old monkeys a lot ... GABA restored selectivity, so the cells worked better ... What's true for vision probably is true for other functions controlled by the cortex ... GABA is found throughout the brain, so if GABA function is diminished,
brain function is diminished"
- Gabitril Receives Approval For the Treatment of Epilepsy - Doctor's Guide, 6/17/96 -
"Being the first drug specifically designed as a GABA uptake inhibitor, Gabitril(R) is a new type of antiepileptic drug"
Other possible GABA suppliers:
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