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Home > Anti-aging Research > GABA

GABA (Gamma-aminobutyric acid)

Specific Recommendations:

CME:

  • The Role of GABA in the Pathogenesis and Treatement of Aniety and other Neurophychiatric Disorders - vcu-cme.org, exp. - "The cliché “If you find one thing wrong in the brain, you’ll find more than one” clearly applies to psychiatric disorders. Most individuals with psychiatric disorders suffer from one or more additional disorders at some point, and it is not surprising that many patients require multipledrug therapy to control their symptoms. Unfortunately, many individuals with comorbid psychiatric disorders fail to respond optimally to treatment. It is likely that specific GABA-enhancing agents will play important roles as treatment for patients with anxiety disorders, with or without comorbidity, and as adjunctive therapy in patients with more complicated neuropsychiatric disorders."

News & Research:

  • GABA (Gamma-Amino Butyric Acid)icon - Vitacost Health Library - "Since GABA does not cross the blood-brain barrier very well (i.e., it cannot be transported efficiently into the brain from the bloodstream), virtually all of the GABA found in the brain is manufactured there.1 For that reason, supplemental GABA would not be expected to increase levels of GABA in the brain"
  • Anxiety Protocol - Life Extension Magazine - "Theanine is an amino acid found in green tea and produces a calming effect on the brain (Yokogoshi H et al 1998). It easily crosses the blood-brain barrier and produces subtle changes in biochemistry, including increased production of GABA and dopamine, which cause a tranquilizing effect"
  • PharmaGABA: Natural Support for Stress, Anxiety, and Insomnia - Dr. Murray's Natural Living, 5/17/07
  • Brown rice may act against onset of Alzheimer’s - Nutra USA, 5/25/04 - "Pre-germinated brown rice, high in levels of the nutrient GABA, significantly improved levels of spatial learning in mice"
  • Sleep Problems, Anxiety May Be Connected - WebMD, 9/12/03 - "both sleep and mood problems may result from a lack of the same brain chemical ... The brain chemical -- gamma-aminobutryric acid, or GABA -- is involved in regulating brain activity ... Specifically, GABA deficiencies interfere with the most important stage of sleep -- the "deep" delta sleep" - See iHerb or Vitacosticon GABA products.
  • Study: GABA May Help Brain Aging - Physician's Weekly, 5/26/03
  • GABA Makes Old Brains Act Young Again - WebMD, 5/2/03
  • Chemical helps aging brains feel younger - MSNBC, 5/1/03 - "in old primates, both human and monkey, there is a decline in the levels of GABA, a chemical that inhibits neuron signals in the brain. Without enough of that control, he said, the brain is distracted and overwhelmed by stray signals, in the same way the ear is overwhelmed when trying to hear a whisper at a rock concert ... When minute quantities of GABA were injected directly into neurons, the brains of the older monkeys responded just like those of the young animals ... Added GABA appeared to have no effect on the young"
  • Old Monkey Study Might Help Old Human Brains - HealthDay, 5/1/03 - "brain cells in the old monkeys have lost much of their ability to respond to the specific signals carried by GABA. Giving GABA to young monkeys did very little in terms of brain function, but it helped the old monkeys a lot ... GABA restored selectivity, so the cells worked better ... What's true for vision probably is true for other functions controlled by the cortex ... GABA is found throughout the brain, so if GABA function is diminished, brain function is diminished"
  • Gabitril Receives Approval For the Treatment of Epilepsy - Doctor's Guide, 6/17/96 - "Being the first drug specifically designed as a GABA uptake inhibitor, Gabitril(R) is a new type of antiepileptic drug"

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