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Anti-aging Research > Boswellia.
Boswellia (Boswellia serrata)
Specific Recommendations:
News & Research:
-
On
The Cover: Eating Your Way To Prostate Cancer - Life Extension Magazine,
2/07 - "Boswellia extracts have been
thoroughly studied as natural remedies for inflammatory disorders. A
patented extract from boswellia called 5-LOXIN® has potent ability to
inhibit the enzyme 5-LOX, preventing the formation of protein-degrading
enzymes, and protecting against inflammation-induced events that can promote
tumor angiogenesis" - See
5-LOXIN® products at iHerb
 .
-
Ease Gout Pain - Nutrition Science
News, 7/99 - "During acute gout
attacks, herbal anti-inflammatories
including boswellia (Boswellia
serrata), curcumin (Curcuma
longa), devil's claw (Harpagophytum procumbens)
and yucca (Yucca spp.)
can be tried instead of aspirin or arthritis drugs"
Abstracts:
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Boswellic
acid inhibits growth and metastasis of human colorectal cancer in orthotopic
mouse model by downregulating inflammatory, proliferative, invasive, and
angiogenic biomarkers - Int J Cancer. 2011 Jun 23 - "We found that the oral
administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of
CRC tumors in mice, resulting in decrease in tumor volumes than those seen in
vehicle-treated mice without significant decreases in body weight. In addition,
we observed that AKBA was highly effective in suppressing ascites and distant
metastasis to the liver, lungs, and spleen in orthotopically-implanted tumors in
nude mice. When examined for the mechanism, we found that markers of tumor
proliferation index Ki-67 and the microvessel density CD31; were significantly
downregulated by AKBA treatment. We also found that AKBA significantly
suppressed NF-κB activation in the tumor tissue and expression of
pro-inflammatory (COX2), tumor survival (bcl-2, bcl-xL, IAP-1, survivin),
proliferative (cyclin D1), invasive (ICAM-1, MMP-9) and angiogenic (CXCR4 and
VEGF) biomarkers. When examined for serum and tissue levels of AKBA, a
dose-dependent increase in the levels of the drug was detected, indicating its
bioavailability. Thus, our findings suggest that this boswellic acid analogue
can inhibit the growth and metastasis of human CRC in vivo through
downregulation of cancer-associated biomarkers"
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Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells
through the downregulation of CXCR4 chemokine receptor expression - Int J
Cancer. 2011 Feb 3 - "Ninety percent of cancer-mediated deaths are due to
metastasis of the tumor; however, the mechanisms controlling metastasis remain
poorly understood. Thus, no therapy targeting this process has yet been
approved. Chemokines and their receptors are mediators of chronic inflammation
and have been linked to the metastasis of numerous cancers. More recently, the
Cysteine X Cysteine (CXC) chemokine receptor 4 (CXCR4) has emerged as a key
mediator of tumor metastasis; therefore, identification of inhibitors of this
receptor has the potential to abrogate metastasis. In this report, we
demonstrate that acetyl-11-keto-β-boswellic acid (AKBA), a component of the
therapeutic plant Boswellia serrata, can downregulate CXCR4 expression in
pancreatic cancer cells. The reduction in CXCR4 induced by this terpenoid was
found to be cell-type specific, as its expression was also abrogated in
leukemia, myeloma and breast cancer cell lines. Neither proteasome inhibitors
nor lysosomal stabilization could prevent the AKBA-induced reduction in CXCR4
expression. This downregulation occurred at the transcriptional level.
Suppression of CXCR4 by AKBA was accompanied by the inhibition of pancreatic
cancer cell invasion, which is induced by CXCL12, the ligand for CXCR4. In
addition, abrogation of the expression of chemokine receptor by AKBA was found
in human pancreatic tissues from orthotopic animal model. AKBA also abolished
breast tumor cell invasion, and this effect correlated with the disappearance of
both the CXCR4 messenger RNA and CXCR4 protein. Overall, our results show that
AKBA is a novel inhibitor of CXCR4 expression and, thus, has the potential to
suppress the invasion and metastasis of cancer cells"
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Inhibition
of microsomal prostaglandin E(2) synthase-1 as a molecular basis for the
anti-inflammatory actions of boswellic acids from frankincense - Br J
Pharmacol. 2010 Sep 14 - "BAs reversibly suppressed the transformation of
prostaglandin (PG)H(2) to PGE(2) mediated by mPGES1 (IC(50) = 3-10 µM). Also in
intact A549 cells, BAs selectively inhibited PGE(2) generation and, in human
whole blood, β-BA reduced lipopolysaccharide-induced PGE(2) biosynthesis without
affecting formation of the COX-derived metabolites 6-keto PGF(1α) and
thromboxane B(2) . Intraperitoneal or oral administration of β-BA (1 mg kg(-1) )
suppressed rat pleurisy, accompanied by impaired levels of PGE(2) ,.and β-BA (1
mg kg(-1) , given i.p.) also reduced mouse paw oedema, both induced by
carrageenan. Conclusions and implications: Suppression of PGE(2) formation by
BAs via interference with mPGES1 contributed to the anti-inflammatory
effectiveness of BAs and of frankincense, and may constitute a biochemical basis
for their anti-inflammatory properties"
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