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Home > Anti-aging Research > Blueberry Extract

Blueberry Extract

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News & Research:

  • Nutritional supplement improves cognitive performance in older adults, study finds - Science Daily, 2/6/14 - "The USF-developed nutritional supplement, containing extracts from blueberries and green tea combined with vitamin D3 and amino acids, including carnosine, was tested by the USF researchers in a clinical trial enrolling 105 healthy adults, ages 65 to 85 ... called NT-020 ... Those randomized to the group of 52 volunteers receiving NT-020 demonstrated improvements in cognitive processing speed, while the 53 volunteers randomized to receive a placebo did not ... Blueberries, a major ingredient in the NT-020 formula, are rich in polyphenols ... NT-020 is 95 percent polyphenols" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com and carnosine products at Amazon.com.
  • Health Benefits of Wild Blueberries Abound - Science Daily, 11/6/13 - "regular long-term wild blueberry diets may help improve or prevent pathologies associated with the metabolic syndrome, including cardiovascular disease and diabetes ... According to the study, wild blueberry consumption (2 cups per day, human equivalent) for 8 weeks was shown to regulate and improve the balance between relaxing and constricting factors in the vascular wall, improving blood flow and blood pressure regulation of obese Zucker rats with metabolic syndrome ... Our recent findings reported elsewhere, documented that wild blueberries reduce chronic inflammation and improve the abnormal lipid profile and gene expression associated with the MetS" - See blueberry extract at Amazon.com.  Also Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com contains blueberry extract
  • Consumption of Certain Fruits Linked to Lower Diabetes Risk - Medscape, 8/29/13 - "Eating certain whole fruits may reduce the risk for type 2 diabetes ... However, juice consumption may up the risk for diabetes ... combined data from 3 studies: the Nurses' Health Study (n = 66,105), Nurses' Health Study II (n = 85,104), and Health Professionals Follow-up Study (n = 36,173) ... blueberries: HR, 0.74 ... grapes and raisins: HR, 0.88 ... apples and pears: HR, 0.93 ... bananas: HR, 0.95 ... grapefruit: HR, 0.95"
  • Strawberries, blueberries may cut heart attack risk in women - Science Daily, 1/14/13 - "Blueberries and strawberries contain high levels of naturally occurring compounds called dietary flavonoids, also found in grapes and wine, blackberries, eggplant, and other fruits and vegetables. A specific sub-class of flavonoids, called anthocyanins, may help dilate arteries, counter the buildup of plaque and provide other cardiovascular benefits ... Nurses' Health Study II ... women completed questionnaires about their diet every four years for 18 years ... Women who ate the most blueberries and strawberries had a 32-percent reduction in their risk of heart attack compared to women who ate the berries once a month or less"
  • Eating more berries may reduce cognitive decline in the elderly - Science Daily, 4/26/12 - "The research team used data from the Nurses' Health Study -- a cohort of 121,700 female, registered nurses between the ages of 30 and 55 who completed health and lifestyle questionnaires beginning in 1976 ... increased consumption of blueberries and strawberries appear to slow cognitive decline in older women. A greater intake of anthocyanidins and total flavonoids was also associated with reduce cognitive degeneration. Researchers observed that women who had higher berry intake delayed cognitive aging by up to 2.5 years ... while they did control for other health factors in the modeling, they cannot rule out the possibility that the preserved cognition in those who eat more berries may be also influenced by other lifestyle choices, such as exercising more"
  • Eating flavonoids protects men against Parkinson's disease, study finds - Science Daily, 4/4/12 - "This latest study is the first study in humans to show that flavonoids can protect neurons against diseases of the brain such as Parkinson's ... male participants who ate the most flavonoids were shown to be 40 per cent less likely to develop the disease than those who ate the least. No similar link was found for total flavonoid intake in women ... a sub-class of flavonoids called anthocyanins may have neuroprotective effects ... In this study the main protective effect was from higher intake of anthocyanins, which are present in berries and other fruits and vegetables including aubergines, blackcurrants and blackberries. Those who consumed the most anthocyanins had a 24 per cent reduction in risk of developing Parkinson's disease and strawberries and blueberries were the top two sources in the US diet"
  • Eating berries benefits the brain - Science Daily, 3/7/12 - "blueberries, blackberries, strawberries and other berry fruits ... berry fruits help the brain stay healthy in several ways. Berry fruits contain high levels of antioxidants, compounds that protect cells from damage by harmful free radicals ... berry fruits change the way neurons in the brain communicate. These changes in signaling can prevent inflammation in the brain that contribute to neuronal damage and improve both motor control and cognition"
  • Blueberry powder may slow breast tumor growth: Mouse data - Nutra USA, 9/20/11 - "The California-based researchers performed two separate experiments. The first put mice in one of three diet groups: A control diet or the diet supplemented with 5% or 10% blueberry powder ... After two weeks of feeding the mice received injections containing aggressive breast cancer cells. After a further six weeks of observation the researchers reported that the 5 and 10% blueberry groups displayed a 75 and 60% reduction in tumor size, compared to the control group ... In addition, results from molecular analysis revealed that blueberry consumption was associated with an alteration in the expression of genes related to inflammation, cancer, and metastasis in such a way that cancer risk would most likely decline ... This suggests that there may be an optimal level of blueberry intake" - [Abstract]
  • Blueberries help lab rats build strong bones - Science Daily, 6/21/11 - "animals fed rations that contained 10 percent freeze-dried blueberry powder had significantly more bone mass than their counterparts whose rations were blueberry-free ... When the researchers exposed laboratory cultures of bone-forming cells (osteoblasts) to blood (serum) from the animals, the scientists found that serum from the blueberry-fed rats was associated with an increase in development of osteoblasts into mature, functional bone cells"
  • Breast cancer research: Mammary gland development of blueberry-fed lab animals studied - Science Daily, 6/7/11 - "several indicators of rat mammary gland health were improved in the offspring (pups) of mothers (dams) that had been fed 5 percent blueberry powder in their rations during pregnancy and during the weeks that they nursed their pups ... In their analysis of several biochemical indicators, the team found, for instance, that the level of the tumor-suppressing protein PTEN (phosphatase and tensin homolog deleted in chromosome 10) was significantly higher in mammary tissues of offspring of dams on the 5 percent regimen. That's a plus, because PTEN is thought to help protect against cancer"
  • Blueberry's effects on cholesterol examined in lab animal study - Science Daily, 6/1/11 - "all the hamsters that were fed blueberry-enhanced rations had from 22 to 27 percent lower total plasma cholesterol than hamsters fed rations that didn't contain blueberry juice byproducts ... Levels of VLDL (very low density lipoprotein-a form of "bad" cholesterol) were about 44 percent lower in the blueberry-fed hamsters"
  • Blueberries may inhibit development of fat cells - Science Daily, 4/10/11 - "The benefits of blueberry consumption have been demonstrated in several nutrition studies, more specifically the cardio-protective benefits derived from their high polyphenol content. Blueberries have shown potential to have a positive effect on everything from aging to metabolic syndrome ... The study was performed in tissue cultures taken from mice. The polyphenols showed a dose-dependent suppression of adipocyte differentiation. The lipid content in the control group was significantly higher than the content of the tissue given three doses of blueberry polyphenols. The highest dose of blueberry polyphenols yielded a 73% decrease in lipids; the lowest dose showed a 27% decrease"
  • Eating berries may lower risk of Parkinson's - Science Daily - Science Daily, 2/13/11 - "Flavonoids are found in plants and fruits and are also known collectively as vitamin P and citrin. They can also be found in berry fruits, chocolate, and citrus fruits such as grapefruit ... participants were followed for 20 to 22 years ... the top 20 percent who consumed the most flavonoids were about 40 percent less likely to develop Parkinson's disease than the bottom 20 percent of male participants who consumed the least amount of flavonoids. In women, there was no relationship between overall flavonoid consumption and developing Parkinson's disease. However, when sub-classes of flavonoids were examined, regular consumption of anthocyanins, which are mainly obtained from berries, were found to be associated with a lower risk of Parkinson's disease in both men and women"
  • Strawberries, Blueberries May Ward Off High Blood Pressure - WebMD, 1/21/11
  • Bioactive compounds in berries can reduce high blood pressure - Science Daily, 1/14/11 - "bioactive compounds in blueberries called anthocyanins offer protection against hypertension. Compared with those who do not eat blueberries, those eating at least one serving a week reduce their risk of developing the condition by 10 per cent"
  • Blueberries and other purple fruits to ward off Alzheimer's, Multiple Sclerosis and Parkinson's - Science Daily, 12/7/10 - "Eating purple fruits such as blueberries and drinking green tea can help ward off diseases including Alzheimer's, Multiple Sclerosis and Parkinson's ... the majority of debilitating illnesses are in part caused by poorly-bound iron which causes the production of dangerous toxins that can react with the components of living systems ... These toxins, called hydroxyl radicals, cause degenerative diseases of many kinds in different parts of the body ... In order to protect the body from these dangerous varieties of poorly-bound iron, it is vital to take on nutrients, known as iron chelators, which can bind the iron tightly"
  • Blueberries linked to improved blood vessel health: Rat study - Nutra USA, 11/18/10 - "Our data provide clear evidence that the 8 week dietary treatment with 8 percent wild blueberry in the adult SHR with established endothelial dysfunction results in a significant moderation of the increased aortic vascular tone ... The berries were proposed to act via the NO pathway – nitric oxide is a potent vasodilator, or compound that promotes the dilation or relaxation of blood vessels, thereby easing blood pressure" - [Abstract]
  • Blueberries help fight artery hardening, lab animal study indicates - Science Daily, 9/29/10 - "Atherosclerosis is the leading cause of two forms of cardiovascular disease--heart attacks and strokes. Cardiovascular disease is the number one killer of Americans ... Lesion size, measured at two sites on aorta (arteries leading from the heart), was 39 and 58 percent less than that of lesions in mice whose diet did not contain blueberry powder ... The blueberry-spiked diet contained 1 percent blueberry powder, the equivalent of about a half-cup of fresh blueberries"
  • Blueberries show anti-diabetic potential: Study - Science Daily, 9/13/10 - "Obese, non-diabetic, and insulin-resistant participants who consumed a blueberry smoothie daily for six weeks experienced a 22 percent change in insulin sensitivity, compared to only 4.9 percent in the placebo group ... The United States Highbush Blueberry Council (USHBC) prepared the freeze-dried whole blueberry powder used in this study" - [Abstract]
  • Nutrient blend improves function of aging brain: rat study - Nutra USA, 7/21/10 - "NT-020 is a combination of blueberry, green tea extract, carnosine and vitamin D3 ... The NT-020 group demonstrated increased adult neural stem cell proliferation in the two main stem cell niches in the brains and improvement in learning and memory"
  • Natural substance NT-020 aids aging brains in rats, study finds - Science Daily, 7/20/10 - "Aging has been linked to oxidative stress, and we have previously shown that natural compounds made from blueberries, green tea, and amino acids, such as carnosine, are high in antioxidants and have anti-inflammatory and anti-oxidative activity .... The combination of these nutrients, called NT-020, creates a synergistic effect that promotes the proliferation of stem cells in the aged animals ... NT-020 may have not only a positive effect on the stem cell niche ... NT-020 may have far-reaching effects on organ function beyond the replacement of injured cells, as demonstrated by cognitive improvement in the NT-020 group"
  • Blueberry ameliorates hepatic fibrosis, study finds - Science Daily, 6/17/10 - "An increasing number of natural substances have been studied to explore if they have protective effects on the liver. Blueberries have unique effects on human retinal, brain and tumor cells, but reports about the effects of blueberries on liver diseases are lacking ... The authors suggest that blueberry consumption is beneficial for hepatic diseases (including fibrosis)" - See blueberry extract at Amazon.com.
  • Blueberries may protect muscles from exercise damage - Nutra USA, 4/2/10 - "Although it is difficult to deduce the biological significance of the data presented here from in vitro studies, one may speculate that consumption of blueberry fruit polyphenolics and particularly malvidin glycosides may be beneficial in alleviating the damaging consequences of oxidative stress in muscle tissue" - [Abstract]
  • Blueberries counteract intestinal diseases - Science Daily, 2/8/10 - "blueberry fibre are important and can alleviate and protect against intestinal inflammations, such as ulcerative colitis. The protective effect is even better if the blueberries are eaten together with probiotics ... probiotics proved to have a protective effect on the liver, an organ that is often negatively impacted by intestinal inflammations"
  • Blueberry juice improves memory in older adults - Science Daily, 1/20/10 - "In the study, one group of volunteers in their 70s with early memory decline drank the equivalent of 2-2 l/2 cups of a commercially available blueberry juice every day for two months. A control group drank a beverage without blueberry juice. The blueberry juice group showed significant improvement on learning and memory tests"
  • Blueberries May Help Reduce Belly Fat, Diabetes Risk - Science Daily, 4/19/09
  • Blueberries May Banish Belly Fat - WebMD, 4/19/08 - "enriched with whole blueberry powder or carbohydrates as 2% of their total diet ... After 90 days, the rats fed blueberries had less abdominal fat, lower cholesterol, and improved glucose control and insulin sensitivity. The latter two factors are markers of how well the body processes sugar for energy and are related to diabetes risk"
  • Blueberries May Shrink Tumors in Babies - WebMD, 1/21/09 - "Mice with blood vessel tumors that were fed the blueberry extract lived twice as long as mice that did not get the substance and had tumors 60% smaller than mice that did not receive blueberry extract treatment ... Oral administration of blueberry extract represents a potential therapeutic strategy for treating endothelial cell tumors in children" - See blueberry extract at Amazon.com.

Abstracts:

  • Blueberry Supplementation Improves Memory in Middle-Aged Mice Fed a High-Fat Diet - J Agric Food Chem. 2014 Jan 21 - "To determine if supplementation of a high-fat diet with blueberries offers protection against putative high-fat diet-related declines, nine month old C57Bl/6 mice were maintained on low fat (10% fat calories) or high-fat (60% fat calories) diets with and without 4% freeze-dried blueberry powder ... Blueberry-supplementation prevented recognition memory deficits after 4 months on the diets ... After 5 months on the diets, mice consuming high-fat diet passed through the platform location less often than mice on low-fat diets during probe trials on days two and three of Morris water maze testing, whereas mice consuming high-fat blueberry diet passed through the platform location as often as mice on the low-fat diets" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Whole Blueberry Powder Inhibits Metastasis of Triple Negative Breast Cancer in a Xenograft Mouse Model Through Modulation of Inflammatory Cytokines - Nutr Cancer. 2013 Dec 23 - "Triple negative breast cancer (TNBC) comprises approximately 15% of breast cancers and is associated with a poor prognosis ... we induced a proinflammatory microenvironment by feeding female MDA-MB-231 tumor-bearing mice a high fat western diet (W) with 5% whole blueberry powder (BB) and studied the effect on tumor formation and metastasis. We showed that mice fed a BB diet had significantly smaller tumors, less ulceration, and significantly less metastasis to the inguinal lymph nodes than mice fed a W diet. In BB-fed mice, serum levels of specific antiinflammatory cytokines were increased and specific cytokine expression was also altered. Together, these results suggest that blueberries may inhibit TNBC and TNBC-related metastasis by reducing inflammation via specific cytokine-driven pathways and thus reduce tumor growth and metastasis" - See blueberry extract at Amazon.com and Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity - Am J Clin Nutr. 2013 Sep 4 - "Blueberry intake acutely improves vascular function in healthy men in a time- and intake-dependent manner. These benefits may be mechanistically linked to the actions of circulating phenolic metabolites on neutrophil NADPH oxidase activity"
  • Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis - Andrologia. 2013 Aug 19 - "Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB-4 could reverse oxidative stress in epididymis ... Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB-4 can prevent the effects of IHH in rat epididymis"
  • High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women - Circulation. 2013 Jan 15 - "We followed up 93 600 women 25 to 42 years of age from the Nurses' Health Study (NHS) II who were healthy at baseline (1989) to examine the relationship between anthocyanins and other flavonoids and the risk of MI. Intake of flavonoid subclasses was calculated from validated food-frequency questionnaires ... An inverse association between higher intake of anthocyanins and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval, 0.49-0.96; P=0.03, highest versus lowest quintiles) after multivariate adjustment ... Combined intake of 2 anthocyanin-rich foods, blueberries and strawberries, tended to be associated with a decreased risk of MI (hazard ratio, 0.66; 95% confidence interval, 0.40-1.08) in a comparison of those consuming >3 servings a week and those with lower intake. Intakes of other flavonoid subclasses were not significantly associated with MI risk"
  • Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats - Br J Nutr. 2012 Oct 9:1-9 - "Rats were randomly assigned to follow a control chow diet, a chow diet supplemented with 2 % (w/w) BB, a high-fat diet (10 % lard; 0.5 % cholesterol) or the high fat plus BB for 10 weeks. Rats supplemented with BB showed significant reductions in systolic BP (SBP) of 11 and 14 %, at weeks 8 and 10, respectively, relative to rats fed the control chow diet (week 8 SBP: 107.5 (sem 4.7) v. 122.2 (sem 2.1) mmHg, P = 0.018; week 10 SBP: 115.0 (sem 3.1) v. 132.7 (sem 1.5) mmHg, P < 0.0001). Furthermore, SBP was reduced by 14 % in rats fed with the high fat plus 2 % BB diet at week 10, compared to those on the high-fat diet only (SBP: 118.2 (sem 3.6) v. 139.5 (sem 4.5) mmHg, P < 0.0001). Aortas harvested from BB-fed animals exhibited significantly reduced contractile responses (to l-phenylephrine) compared to those fed the control chow or high-fat diets. Furthermore, in rats fed with high fat supplemented with BB, aorta relaxation was significantly greater in response to acetylcholine compared to animals fed with the fat diet"
  • Whole Blueberry Powder Modulates the Growth and Metastasis of MDA-MB-231 Triple Negative Breast Tumors in Nude Mice - J Nutr. 2011 Aug 31 - "In this study, tumor volume was 75% lower in mice fed the 5% BB diet and 60% lower in mice fed the 10% BB diet than in control mice (P ≤ 0.05). Tumor cell proliferation (Ki-67) was lower in the 5 and 10% BB-fed mice and cell death (Caspase 3) was greater in the 10% BB-fed mice compared to control mice (P ≤ 0.05). Gene analysis of tumor tissues from the 5% BB-fed mice revealed significantly altered expression of genes important to inflammation, cancer, and metastasis, specifically, Wnt signaling, thrombospondin-2, IL-13, and IFNγ. To confirm effects on Wnt signaling, analysis of tumor tissues from 5% BB-fed mice revealed lower β-catenin expression and glycogen synthase kinase-3β phosphorylation with greater expression of the β-catenin inhibitory protein adenomatous polyposis coli compared to controls. A second study tested the ability of the 5% BB diet to inhibit MDA-MB-231-luc-D3H2LN metastasis in vivo. In this study, 5% BB-fed mice developed 70% fewer liver metastases (P = 0.04) and 25% fewer lymph node metastases (P = 0.09) compared to control mice. This study demonstrates the oral antitumor and metastasis activity of whole BB powder against TNBC in mice"
  • A Wild Blueberry-Enriched Diet ( Vaccinium angustifolium ) Improves Vascular Tone in the Adult Spontaneously Hypertensive Rat - J Agric Food Chem. 2010 Nov 24 - "The vasoconstriction elicited by Phe was reduced in the WB group, attributed to the NO pathway, favoring a lower vascular tone under basal conditions. Acetylcholine-induced vasorelaxation in the WB group was possibly mediated through the COX, but not the NO pathway. These findings document the potential of wild blueberries to modify major pathways of vasomotor control and improve the vascular tone in the adult SHR with endothelial dysfunction"
  • Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women - J Nutr. 2010 Aug 19 - "Participants were randomized to consume either a smoothie containing 22.5 g blueberry bioactives (blueberry group, n = 15) or a smoothie of equal nutritional value without added blueberry bioactives (placebo group, n = 17) twice daily for 6 wk. Both groups were instructed to maintain their body weight by reducing ad libitum intake by an amount equal to the energy intake of the smoothies. Participants' body weights were evaluated weekly and 3-d food records were collected at baseline, the middle, and end of the study. The mean change in insulin sensitivity improved more in the blueberry group (1.7 +/- 0.5 mg.kg FFM(-1).min(-1)) than in the placebo group (0.4 +/- 0.4 mg.kg FFM(-1).min(-1)) (P = 0.04). Insulin sensitivity was enhanced in the blueberry group at the end of the study without significant changes in adiposity, energy intake, and inflammatory biomarkers. In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants"
  • Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome - J Nutr. 2010 Jul 21 - "Forty-eight participants with metabolic syndrome [4 males and 44 females; BMI: 37.8 +/- 2.3 kg/m(2); age: 50.0 +/- 3.0 y (mean +/- SE)] consumed freeze-dried blueberry beverage (50 g freeze-dried blueberries, approximately 350 g fresh blueberries) or equivalent amounts of fluids (controls, 960 mL water) daily for 8 wk in a randomized controlled trial. Anthropometric and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screening and at wk 4 and 8 of the study. The decreases in systolic and diastolic blood pressures were greater in the blueberry-supplemented group (-6 and -4%, respectively) than in controls (-1.5 and -1.2%) (P < 0.05), whereas the serum glucose concentration and lipid profiles were not affected. The decreases in plasma oxidized LDL and serum malondialdehyde and hydroxynonenal concentrations were greater in the blueberry group (-28 and -17%, respectively) than in the control group (-9 and -9%) (P < 0.01). Our study shows blueberries may improve selected features of metabolic syndrome and related cardiovascular risk factors at dietary achievable doses"
  • Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro - Mol Nutr Food Res. 2010 Mar;54(3):353-63 - "These in vitro data support the concept that blueberry fruits or derived foods rich in malvidin glycosides may be beneficial in alleviating muscle damage caused by oxidative stress" - See blueberry extract at Amazon.com.
  • Dietary Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice - J Nutr. 2010 Jan 20 - "Blueberries or bilberries contain large amounts of anthocyanins, making them one of the richest sources of dietary anthocyanin ... bilberry extract (BBE) ... Dietary BBE significantly reduced the blood glucose concentration and enhanced insulin sensitivity ... These findings provide a biochemical basis for the use of bilberry fruits and have important implications for the prevention and treatment of type 2 diabetes via activation of AMPK" - See bilberry at Amazon.com.
  • Blueberry Supplementation Improves Memory in Older Adults (dagger) - J Agric Food Chem. 2010 Jan 4 - "Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have antioxidant and anti-inflammatory effects. In addition, anthocyanins have been associated with increased neuronal signaling in brain centers, mediating memory function as well as improved glucose disposal, benefits that would be expected to mitigate neurodegeneration ... At 12 weeks, improved paired associate learning (p = 0.009) and word list recall (p = 0.04) were observed. In addition, there were trends suggesting reduced depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also compared the memory performances of the blueberry subjects with a demographically matched sample who consumed a berry placebo beverage in a companion trial of identical design and observed comparable results for paired associate learning. The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms"
  • Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects - Am J Clin Nutr. 2009 Jul 29 - "Anthocyanin consumption increased HDL-cholesterol concentrations (13.7% and 2.8% in the anthocyanin and placebo groups, respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6% and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001). The cellular cholesterol efflux to serum increased more in the anthocyanin group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001). Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3% in the anthocyanin group and -3.5% and 1.1% in the placebo group, respectively; P < 0.001)" - See blueberry extract at Amazon.com and bilberry at Amazon.com.
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