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Anti-aging Research > Blueberry Extract
Blueberry Extract
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News & Research:
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Strawberries, blueberries may cut heart attack risk in women - Science
Daily, 1/14/13 - "Blueberries and strawberries contain
high levels of naturally occurring compounds called dietary flavonoids, also
found in grapes and wine, blackberries, eggplant, and other fruits and
vegetables. A specific sub-class of flavonoids, called anthocyanins, may help
dilate arteries, counter the buildup of plaque and provide other cardiovascular
benefits ... Nurses' Health Study II ... women completed questionnaires about
their diet every four years for 18 years ... Women who ate the most blueberries
and strawberries had a 32-percent reduction in their risk of heart attack
compared to women who ate the berries once a month or less" - See
Garden of Life, Radical Fruits Antioxidant Complex, 60 Caplets at iHerb.
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Eating
more berries may reduce cognitive decline in the elderly - Science Daily,
4/26/12 - "The research team used data from the Nurses'
Health Study -- a cohort of 121,700 female, registered nurses between the ages
of 30 and 55 who completed health and lifestyle questionnaires beginning in 1976
... increased consumption of blueberries and strawberries appear to slow
cognitive decline in older women. A greater intake of anthocyanidins and total
flavonoids was also associated with reduce cognitive degeneration. Researchers
observed that women who had higher berry intake delayed cognitive aging by up to
2.5 years ... while they did control for other health factors in the modeling,
they cannot rule out the possibility that the preserved cognition in those who
eat more berries may be also influenced by other lifestyle choices, such as
exercising more"
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Eating
flavonoids protects men against Parkinson's disease, study finds - Science
Daily, 4/4/12 - "This latest study is the first study in
humans to show that flavonoids can protect neurons against diseases of the brain
such as Parkinson's ... male participants who ate the most flavonoids were shown
to be 40 per cent less likely to develop the disease than those who ate the
least. No similar link was found for total flavonoid intake in women ... a
sub-class of flavonoids called anthocyanins may have neuroprotective effects ...
In this study the main protective effect was from higher intake of anthocyanins,
which are present in berries and other fruits and vegetables including
aubergines, blackcurrants and blackberries. Those who consumed the most
anthocyanins had a 24 per cent reduction in risk of developing Parkinson's
disease and strawberries and blueberries were the top two sources in the US
diet"
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Eating
berries benefits the brain - Science Daily, 3/7/12 -
"blueberries, blackberries, strawberries and other berry fruits ... berry fruits
help the brain stay healthy in several ways. Berry fruits contain high levels of
antioxidants, compounds that protect cells from damage by harmful free radicals
... berry fruits change the way neurons in the brain communicate. These changes
in signaling can prevent inflammation in the brain that contribute to neuronal
damage and improve both motor control and cognition"
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Blueberry powder may slow breast tumor growth: Mouse data - Nutra USA,
9/20/11 - "The California-based researchers performed two separate experiments.
The first put mice in one of three diet groups: A control diet or the diet
supplemented with 5% or 10% blueberry powder ... After two weeks of feeding the
mice received injections containing aggressive breast cancer cells. After a
further six weeks of observation the researchers reported that the 5 and 10%
blueberry groups displayed a 75 and 60% reduction in tumor size, compared to the
control group ... In addition, results from molecular analysis revealed that
blueberry consumption was associated with an alteration in the expression of
genes related to inflammation, cancer, and metastasis in such a way that cancer
risk would most likely decline ... This suggests that there may be an optimal
level of blueberry intake" - [Abstract]
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Blueberries help lab rats build strong bones - Science Daily, 6/21/11 -
"animals fed rations that contained 10 percent freeze-dried blueberry powder had
significantly more bone mass than their counterparts whose rations were
blueberry-free ... When the researchers exposed laboratory cultures of
bone-forming cells (osteoblasts) to blood (serum) from the animals, the
scientists found that serum from the blueberry-fed rats was associated with an
increase in development of osteoblasts into mature, functional bone cells"
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Breast
cancer research: Mammary gland development of blueberry-fed lab animals studied
- Science Daily, 6/7/11 - "several indicators of rat mammary gland health were
improved in the offspring (pups) of mothers (dams) that had been fed 5 percent
blueberry powder in their rations during pregnancy and during the weeks that
they nursed their pups ... In their analysis of several biochemical indicators,
the team found, for instance, that the level of the tumor-suppressing protein
PTEN (phosphatase and tensin homolog deleted in chromosome 10) was significantly
higher in mammary tissues of offspring of dams on the 5 percent regimen. That's
a plus, because PTEN is thought to help protect against cancer"
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Blueberry's effects on cholesterol examined in lab animal study - Science
Daily, 6/1/11 - "all the hamsters that were fed blueberry-enhanced rations had
from 22 to 27 percent lower total plasma cholesterol than hamsters fed rations
that didn't contain blueberry juice byproducts ... Levels of VLDL (very low
density lipoprotein-a form of "bad" cholesterol) were about 44 percent lower in
the blueberry-fed hamsters"
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Blueberries may inhibit development of fat cells - Science Daily, 4/10/11 -
"The benefits of blueberry consumption have been demonstrated in several
nutrition studies, more specifically the cardio-protective benefits derived from
their high polyphenol content. Blueberries have shown potential to have a
positive effect on everything from aging to metabolic syndrome ... The study was
performed in tissue cultures taken from mice. The polyphenols showed a
dose-dependent suppression of adipocyte differentiation. The lipid content in
the control group was significantly higher than the content of the tissue given
three doses of blueberry polyphenols. The highest dose of blueberry polyphenols
yielded a 73% decrease in lipids; the lowest dose showed a 27% decrease"
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Eating
berries may lower risk of Parkinson's - Science Daily - Science Daily,
2/13/11 - "Flavonoids are found in plants and fruits and are also known
collectively as vitamin P and citrin. They can also be found in berry fruits,
chocolate, and citrus fruits such as grapefruit ... participants were followed
for 20 to 22 years ... the top 20 percent who consumed the most flavonoids were
about 40 percent less likely to develop Parkinson's disease than the bottom 20
percent of male participants who consumed the least amount of flavonoids. In
women, there was no relationship between overall flavonoid consumption and
developing Parkinson's disease. However, when sub-classes of flavonoids were
examined, regular consumption of anthocyanins, which are mainly obtained from
berries, were found to be associated with a lower risk of Parkinson's disease in
both men and women"
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Strawberries, Blueberries May Ward Off High Blood Pressure - WebMD, 1/21/11
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Bioactive compounds in berries can reduce high blood pressure - Science
Daily, 1/14/11 - "bioactive compounds in blueberries called anthocyanins offer
protection against hypertension. Compared with those who do not eat blueberries,
those eating at least one serving a week reduce their risk of developing the
condition by 10 per cent"
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Blueberries and other purple fruits to ward off Alzheimer's, Multiple Sclerosis
and Parkinson's - Science Daily, 12/7/10 - "Eating
purple fruits such as blueberries and drinking green tea can help ward off
diseases including Alzheimer's, Multiple Sclerosis and Parkinson's ... the
majority of debilitating illnesses are in part caused by poorly-bound iron which
causes the production of dangerous toxins that can react with the components of
living systems ... These toxins, called hydroxyl radicals, cause degenerative
diseases of many kinds in different parts of the body ... In order to protect
the body from these dangerous varieties of poorly-bound iron, it is vital to
take on nutrients, known as iron chelators, which can bind the iron tightly"
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Blueberries linked to improved blood vessel health: Rat study - Nutra USA,
11/18/10 - "Our data provide clear evidence that the 8 week dietary treatment
with 8 percent wild blueberry in the adult SHR with established endothelial
dysfunction results in a significant moderation of the increased aortic vascular
tone ... The berries were proposed to act via the NO pathway – nitric oxide is a
potent vasodilator, or compound that promotes the dilation or relaxation of
blood vessels, thereby easing blood pressure" - [Abstract]
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Blueberries help fight artery hardening, lab animal study indicates -
Science Daily, 9/29/10 - "Atherosclerosis is the leading cause of two forms of
cardiovascular disease--heart attacks and strokes. Cardiovascular disease is the
number one killer of Americans ... Lesion size, measured at two sites on aorta
(arteries leading from the heart), was 39 and 58 percent less than that of
lesions in mice whose diet did not contain blueberry powder ... The
blueberry-spiked diet contained 1 percent blueberry powder, the equivalent of
about a half-cup of fresh blueberries"
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Blueberries show anti-diabetic potential: Study - Science Daily, 9/13/10 -
"Obese, non-diabetic, and insulin-resistant participants who consumed a
blueberry smoothie daily for six weeks experienced a 22 percent change in
insulin sensitivity, compared to only 4.9 percent in the placebo group ... The
United States Highbush Blueberry Council (USHBC) prepared the freeze-dried whole
blueberry powder used in this study" - [Abstract]
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Nutrient blend improves function of aging brain: rat study - Nutra USA,
7/21/10 - "NT-020 is a combination of blueberry, green
tea extract, carnosine and vitamin D3 ... The NT-020 group demonstrated
increased adult neural stem cell proliferation in the two main stem cell niches
in the brains and improvement in learning and memory"
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Natural
substance NT-020 aids aging brains in rats, study finds - Science Daily,
7/20/10 - "Aging has been linked to oxidative stress,
and we have previously shown that natural compounds made from blueberries, green
tea, and amino acids, such as carnosine, are high in antioxidants and have
anti-inflammatory and anti-oxidative activity .... The combination of these
nutrients, called NT-020, creates a synergistic effect that promotes the
proliferation of stem cells in the aged animals ... NT-020 may have not only a
positive effect on the stem cell niche ... NT-020 may have far-reaching effects
on organ function beyond the replacement of injured cells, as demonstrated by
cognitive improvement in the NT-020 group"
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Blueberry ameliorates hepatic fibrosis, study finds - Science Daily, 6/17/10
- "An increasing number of natural substances have been studied to explore if
they have protective effects on the liver. Blueberries have unique effects on
human retinal, brain and tumor cells, but reports about the effects of
blueberries on liver diseases are lacking ... The authors suggest that blueberry
consumption is beneficial for hepatic diseases (including fibrosis)" - See
blueberry extracts at iHerb.
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Blueberries may protect muscles from exercise damage - Nutra USA, 4/2/10 -
"Although it is difficult to deduce the biological significance of the data
presented here from in vitro studies, one may speculate that consumption of
blueberry fruit polyphenolics and particularly malvidin glycosides may be
beneficial in alleviating the damaging consequences of oxidative stress in
muscle tissue" - [Abstract]
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Blueberries counteract intestinal diseases - Science Daily, 2/8/10 -
"blueberry fibre are important and can alleviate and protect against intestinal
inflammations, such as ulcerative colitis. The protective effect is even better
if the blueberries are eaten together with probiotics ... probiotics proved to
have a protective effect on the liver, an organ that is often negatively
impacted by intestinal inflammations"
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Blueberry juice improves memory in older adults - Science Daily, 1/20/10
- "In the study, one group of volunteers in their
70s with early memory decline drank the equivalent of 2-2 l/2 cups of a
commercially available blueberry juice every day for two months. A control
group drank a beverage without blueberry juice. The blueberry juice group
showed significant improvement on learning and memory tests"
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Blueberries May Help Reduce Belly Fat, Diabetes Risk - Science Daily,
4/19/09
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Blueberries May Banish Belly Fat - WebMD, 4/19/08 -
"enriched with whole blueberry powder or
carbohydrates as 2% of their total diet ... After 90 days, the rats fed
blueberries had less abdominal fat, lower cholesterol, and improved glucose
control and insulin sensitivity. The latter two factors are markers of how
well the body processes sugar for energy and are related to diabetes risk"
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Blueberries May Shrink Tumors in Babies - WebMD, 1/21/09 -
"Mice with blood vessel tumors that were fed the
blueberry extract lived twice as long as mice that did not get the substance
and had tumors 60% smaller than mice that did not receive blueberry extract
treatment ... Oral administration of blueberry extract represents a
potential therapeutic strategy for treating endothelial cell tumors in
children" - See
blueberry extracts at iHerb.
Abstracts:
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High
anthocyanin intake is associated with a reduced risk of myocardial infarction in
young and middle-aged women - Circulation. 2013 Jan 15 -
"We followed up 93 600 women 25 to 42 years of age from
the Nurses' Health Study (NHS) II who were healthy at baseline (1989) to examine
the relationship between anthocyanins and other flavonoids and the risk of MI.
Intake of flavonoid subclasses was calculated from validated food-frequency
questionnaires ... An inverse association between higher intake of anthocyanins
and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval,
0.49-0.96; P=0.03, highest versus lowest quintiles) after multivariate
adjustment ... Combined intake of 2 anthocyanin-rich foods, blueberries and
strawberries, tended to be associated with a decreased risk of MI (hazard ratio,
0.66; 95% confidence interval, 0.40-1.08) in a comparison of those consuming >3
servings a week and those with lower intake. Intakes of other flavonoid
subclasses were not significantly associated with MI risk" - See
Garden of Life, Radical Fruits Antioxidant Complex, 60 Caplets at iHerb.
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Blueberry
intervention improves vascular reactivity and lowers blood pressure in
high-fat-, high-cholesterol-fed rats - Br J Nutr. 2012 Oct 9:1-9 -
"Rats were randomly assigned to follow a control chow
diet, a chow diet supplemented with 2 % (w/w) BB, a high-fat diet (10 % lard;
0.5 % cholesterol) or the high fat plus BB for 10 weeks. Rats supplemented with
BB showed significant reductions in systolic BP (SBP) of 11 and 14 %, at weeks 8
and 10, respectively, relative to rats fed the control chow diet (week 8 SBP:
107.5 (sem 4.7) v. 122.2 (sem 2.1) mmHg, P = 0.018; week 10 SBP: 115.0 (sem 3.1)
v. 132.7 (sem 1.5) mmHg, P < 0.0001). Furthermore, SBP was reduced by 14 % in
rats fed with the high fat plus 2 % BB diet at week 10, compared to those on the
high-fat diet only (SBP: 118.2 (sem 3.6) v. 139.5 (sem 4.5) mmHg, P < 0.0001).
Aortas harvested from BB-fed animals exhibited significantly reduced contractile
responses (to l-phenylephrine) compared to those fed the control chow or
high-fat diets. Furthermore, in rats fed with high fat supplemented with BB,
aorta relaxation was significantly greater in response to acetylcholine compared
to animals fed with the fat diet"
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Whole
Blueberry Powder Modulates the Growth and Metastasis of MDA-MB-231 Triple
Negative Breast Tumors in Nude Mice - J Nutr. 2011 Aug 31 -
"In this study, tumor volume was 75% lower in mice fed
the 5% BB diet and 60% lower in mice fed the 10% BB diet than in control mice (P
≤ 0.05). Tumor cell proliferation (Ki-67) was lower in the 5 and 10% BB-fed mice
and cell death (Caspase 3) was greater in the 10% BB-fed mice compared to
control mice (P ≤ 0.05). Gene analysis of tumor tissues from the 5% BB-fed mice
revealed significantly altered expression of genes important to inflammation,
cancer, and metastasis, specifically, Wnt signaling, thrombospondin-2, IL-13,
and IFNγ. To confirm effects on Wnt signaling, analysis of tumor tissues from 5%
BB-fed mice revealed lower β-catenin expression and glycogen synthase kinase-3β
phosphorylation with greater expression of the β-catenin inhibitory protein
adenomatous polyposis coli compared to controls. A second study tested the
ability of the 5% BB diet to inhibit MDA-MB-231-luc-D3H2LN metastasis in vivo.
In this study, 5% BB-fed mice developed 70% fewer liver metastases (P = 0.04)
and 25% fewer lymph node metastases (P = 0.09) compared to control mice. This
study demonstrates the oral antitumor and metastasis activity of whole BB powder
against TNBC in mice"
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A Wild
Blueberry-Enriched Diet ( Vaccinium angustifolium ) Improves Vascular Tone in
the Adult Spontaneously Hypertensive Rat - J Agric Food Chem. 2010 Nov 24 -
"The vasoconstriction elicited by Phe was reduced in the WB group, attributed to
the NO pathway, favoring a lower vascular tone under basal conditions.
Acetylcholine-induced vasorelaxation in the WB group was possibly mediated
through the COX, but not the NO pathway. These findings document the potential
of wild blueberries to modify major pathways of vasomotor control and improve
the vascular tone in the adult SHR with endothelial dysfunction"
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Bioactives
in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and
Women - J Nutr. 2010 Aug 19 - "Participants were
randomized to consume either a smoothie containing 22.5 g blueberry bioactives
(blueberry group, n = 15) or a smoothie of equal nutritional value without added
blueberry bioactives (placebo group, n = 17) twice daily for 6 wk. Both groups
were instructed to maintain their body weight by reducing ad libitum intake by
an amount equal to the energy intake of the smoothies. Participants' body
weights were evaluated weekly and 3-d food records were collected at baseline,
the middle, and end of the study. The mean change in insulin sensitivity
improved more in the blueberry group (1.7 +/- 0.5 mg.kg FFM(-1).min(-1)) than in
the placebo group (0.4 +/- 0.4 mg.kg FFM(-1).min(-1)) (P = 0.04). Insulin
sensitivity was enhanced in the blueberry group at the end of the study without
significant changes in adiposity, energy intake, and inflammatory biomarkers. In
conclusion, daily dietary supplementation with bioactives from whole blueberries
improved insulin sensitivity in obese, nondiabetic, and insulin-resistant
participants"
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Blueberries
Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic
Syndrome - J Nutr. 2010 Jul 21 - "Forty-eight
participants with metabolic syndrome [4 males and 44 females; BMI: 37.8 +/- 2.3
kg/m(2); age: 50.0 +/- 3.0 y (mean +/- SE)] consumed freeze-dried blueberry
beverage (50 g freeze-dried blueberries, approximately 350 g fresh blueberries)
or equivalent amounts of fluids (controls, 960 mL water) daily for 8 wk in a
randomized controlled trial. Anthropometric and blood pressure measurements,
assessment of dietary intakes, and fasting blood draws were conducted at
screening and at wk 4 and 8 of the study. The decreases in systolic and
diastolic blood pressures were greater in the blueberry-supplemented group (-6
and -4%, respectively) than in controls (-1.5 and -1.2%) (P < 0.05), whereas the
serum glucose concentration and lipid profiles were not affected. The decreases
in plasma oxidized LDL and serum malondialdehyde and hydroxynonenal
concentrations were greater in the blueberry group (-28 and -17%, respectively)
than in the control group (-9 and -9%) (P < 0.01). Our study shows blueberries
may improve selected features of metabolic syndrome and related cardiovascular
risk factors at dietary achievable doses"
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Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle
cell damage in vitro - Mol Nutr Food Res. 2010 Mar;54(3):353-63 -
"These in
vitro data support the concept that blueberry fruits or derived foods rich in malvidin glycosides may be beneficial in alleviating muscle damage caused by
oxidative stress" - See
blueberry extracts at iHerb.
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Dietary
Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin
Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice
- J Nutr. 2010 Jan 20 - "Blueberries or bilberries
contain large amounts of anthocyanins, making them one of the richest
sources of dietary anthocyanin ... bilberry extract (BBE) ... Dietary BBE
significantly reduced the blood glucose concentration and enhanced insulin
sensitivity ... These findings provide a biochemical basis for the use of
bilberry fruits and have important implications for the prevention and
treatment of type 2 diabetes via activation of AMPK" - See
bilberry products at iHerb.
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Blueberry Supplementation Improves Memory in Older Adults (dagger) - J
Agric Food Chem. 2010 Jan 4 - "Blueberries contain
polyphenolic compounds, most prominently anthocyanins, which have
antioxidant and anti-inflammatory effects. In addition, anthocyanins have
been associated with increased neuronal signaling in brain centers,
mediating memory function as well as improved glucose disposal, benefits
that would be expected to mitigate neurodegeneration ... At 12 weeks,
improved paired associate learning (p = 0.009) and word list recall (p =
0.04) were observed. In addition, there were trends suggesting reduced
depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also
compared the memory performances of the blueberry subjects with a
demographically matched sample who consumed a berry placebo beverage in a
companion trial of identical design and observed comparable results for
paired associate learning. The findings of this preliminary study suggest
that moderate-term blueberry supplementation can confer neurocognitive
benefit and establish a basis for more comprehensive human trials to study
preventive potential and neuronal mechanisms"
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Anthocyanin supplementation improves serum LDL- and HDL-cholesterol
concentrations associated with the inhibition of cholesteryl ester transfer
protein in dyslipidemic subjects - Am J Clin Nutr. 2009 Jul 29 -
"Anthocyanin consumption increased HDL-cholesterol
concentrations (13.7% and 2.8% in the anthocyanin and placebo groups,
respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6%
and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001).
The cellular cholesterol efflux to serum increased more in the anthocyanin
group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001).
Anthocyanin supplementation decreased the mass and activity of plasma
cholesteryl ester transfer protein (CETP) (10.4% and 6.3% in the anthocyanin
group and -3.5% and 1.1% in the placebo group, respectively; P < 0.001)"
- See
blueberry extracts at iHerb
and
bilberry products at iHerb.
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