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Recent Longevity News for the week ending 10/7/15 Flu Vaccine May Also Protect Against Pneumonia - WebMD, 10/5/15 - "We estimate that approximately 57 percent of hospitalizations due to influenza pneumonia could be prevented by influenza vaccination ... The leading cause of these hospitalizations and deaths is not flu itself, but pneumonia, which is a common complication of flu ... The flu is a great enabler ... It enables heart disease, pneumonia, appendicitis, sore throats and earaches ... And pneumonia is the number one cause of hospitalization and death"
Glutamate: Essential food for the brain - Science Daily, 10/4/15 -
"Devoid of the energy supplied by cerebral
glutamate, the brain sends signals to the liver
to requisition a compensatory proportion of glucose, at the expense of the rest
of the body. This is why the transgenic mice also showed a growth deficit and
muscle atrophy. "This clearly shows how the brain works in a just-in-time manner
and that each percent of energy resources is essential for its proper
functioning," highlights Professor Pierre Maechler. "If a part of this energy
disappears, the brain serves itself first and the rest of the body suffers. The
liver must then make more glucose by drawing upon muscle protein, resulting in
loss of muscle mass. Knowing that the brain uses glutamate as an energy resource
allows us to reflect on other ways to overcome a potential shortfall" -
See
l-glutamic acid at Amazon.com
Omega-3 Fatty Acids for
Breast Cancer Prevention and Survivorship - Medscape, 10/1/15 -
"Women with evidence of high intake ratios of the marine
omega-3 fatty acids eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA) relative to the
omega-6 arachidonic acid have been
found to have a reduced risk of breast cancer
compared with those with low ratios in some but not all case–control and cohort
studies. If increasing EPA and DHA relative to arachidonic acid is effective in
reducing breast cancer risk, likely mechanisms include reduction in
proinflammatory lipid derivatives, inhibition of nuclear factor-κB-induced
cytokine production, and decreased growth factor receptor signaling as a result
of alteration in membrane lipid rafts ... The inflammation-resolving properties
and favorable effects of EPA and DHA on oncogenic proteins, as well as on the
cardiovascular, bone, and central nervous system, make them excellent candidates
for primary and secondary breast cancer prevention trials for individuals at
increased risk as well as breast cancer survivors" - See
fish oil supplements at Amazon.com Calcium From Supplements or Dairy Doesn't Strengthen Bones, Study Finds - NBC News, 9/29/15 - "taking calcium supplements is not just a waste of time, but it could be harmful. The extra calcium doesn't go to strengthen bones but instead can build up in the arteries, causing heart disease, or in the kidneys, causing kidney stones" Abstracts from this week: A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension - J Alzheimers Dis. 2015 Sep 4 - "Thirty-four individuals with mild cognitive impairment were randomized for 6 months to a nutraceutical formulation (NF: folate, alpha-tocopherol, B12, S-adenosyl methioinine, N-acetyl cysteine, acetyl-L-carnitine) or indistinguishable placebo, followed by a 6-month open-label extension in which all individuals received NF. The NF cohort improved in the Dementia Rating Scale (DRS; effect size >0.7) and maintained baseline performance in CLOX-1. The placebo cohort did not improve in DRS and declined in CLOX-1, but during the open-label extension improved in DRS and ceased declining in CLOX-1" - [Nutra USA]
A systematic
review and meta-analysis of the impact of Spirulina supplementation on plasma
lipid concentrations - Clin Nutr. 2015 Sep 25 -
"This meta-analysis showed a significant effect of supplementation with
Spirulina in reducing plasma concentrations of
total cholesterol, LDL-C,
triglycerides and elevating those of
HDL-C" - See
Spirulina at Amazon.com Dairy consumption and risk of metabolic syndrome: a meta-analysis - Diabet Med. 2015 Oct 3 - "In the meta-analysis of prospective cohort studies, the pooled relative risk of incidence of metabolic syndrome for the highest vs. the lowest category of dairy consumption was 0.85 (95% CI 0.73-0.98), and for a 1-serving/day increment of dairy consumption, the pooled relative risk was 0.88 (95% CI 0.82-0.95). In the meta-analysis of cross-sectional studies, the pooled relative risk of prevalence of metabolic syndrome for the highest vs. the lowest category of dairy consumption was 0.73 (95% CI 0.63-0.86)"
Glycine
supplementation during calorie restriction accelerates fat loss and protects
against further muscle loss in obese mice - Clin Nutr. 2015 Sep 25 -
"GLY treated mice lost
more whole-body fat mass (14%, p < 0.05) and epididymal fat mass (26%, P <
0.05), less lean mass (27%, P < 0.05), and had better preserved quadriceps
muscle mass (4%, P < 0.01) than ALA treated mice after 20 d CR ... Taken
together, these findings suggest that glycine supplementation during CR may be
beneficial for preserving muscle mass and stimulating loss of adipose tissue"
- See glycine products at Amazon.com
Antioxidant
treatment ameliorates experimental diabetes-induced depressive-like behavior and
reduces oxidative stress in brain and pancreas - Diabetes Metab Res Rev.
2015 Oct 3 - "This study aimed to evaluate the effects
of antioxidants n-acetylcysteine (NAC) and
deferoxamine (DFX) on behavior and oxidative stress parameters in diabetic rats.
To this aim, after induction of diabetes by a single dose of alloxan, Wistar
rats were treated with NAC or DFX for 14 days and then depressive-like behavior
was evaluated ... Diabetic rats displayed depressive-like behavior and treatment
with NAC reversed this alteration. Carbonyl protein levels were increased in the
PFC, hippocampus, and pancreas of diabetic rats, and both NAC and DFX reversed
these alterations. Lipid damage was increased in the PFC, hippocampus, amygdala,
and pancreas, however treatment with NAC or DFX reversed lipid damage only in
the hippocampus and pancreas" - See
n-acetyl cysteine at Amazon.com
Effects of
Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in
Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized
Clinical Trial - J Am Coll Nutr. 2015 Oct 2:1-6 - "Nonalcoholic
fatty liver disease (NAFLD) is a condition defined by exceeding
triglycerides accumulation in the liver. The condition can develop into
fibrosis, cirrhosis, and hepatocellular carcinoma ... Subjects in the
intervention and control groups consumed 2 capsules/day
probiotic or placebo, respectively, for 8 weeks.
Fasting blood sugar (FBS) ... Means of FBS, insulin, insulin resistance, and
IL-6 were significantly different between groups after intervention (p < 0.05),
whereas TNF-α was not significantly modified (p > 0.05). In the probiotic group,
insulin, insulin resistance, TNF-α, and IL-6 decreased significantly at the end
of the study compared to the beginning of study" - See
probiotic products at Amazon.com Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population - J Atheroscler Thromb. 2015 Oct 1 - "Multivariate-adjusted logistic regression analysis showed that high FT3 levels were associated with low prevalent elevated C-IMT. The adjusted odds ratio for elevated C-IMT was 0.71 (95% confidence interval, 0.52-0.99, P=0.04) when comparing the highest with the lowest quartile of FT3" - See T3 at International Anti-aging Systems. Mente Activa® Improves Impaired Spatial Memory in Aging Rats - J Nutr Health Aging. 2015;19(8):819-27 - "Our data indicate that supplemented rats showed less escape latency, distance swum, higher use of spatial search strategies, and crossed the former platform location with higher frequency than control rats. These effects were specific of the treatment, indicating that this nutritional supplement has a beneficial effect on spatial memory" - Note: The following is what the Google Chrome translate option translates the ingredients too. It sounds like the main active ingredients are the DHA and the phospatidylserine:
Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women - Br J Nutr. 2015 Sep 30 - "Recent evidence suggests that Ca supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain ... We randomised 100 post-menopausal women to 1 g/d of Ca or a placebo containing no Ca ... Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The reduction in systolic blood pressure was smaller in the Ca group compared with the control group by >5 mmHg between 2 and 6 h (P≤0.02), and the reduction in diastolic blood pressure was smaller at 2 h (between-groups difference 4.5 mmHg, P=0.004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the calcium citrate and control groups. At 4 h, the increase in the coagulation index was greater in the calcium citrate group compared with the control group (P=0.03), which appeared to be due to a greater reduction in the time to clot initiation"
The effect of oral
collagen peptide supplementation on skin moisture and the dermal collagen
network: evidence from an ex vivo model and randomized, placebo-controlled
clinical trials - J Cosmet Dermatol. 2015 Sep 12 - "Skin dryness and an
accelerated fragmentation of the collagen network in the dermis are hallmarks of
skin aging. Nutrition is a key factor influencing skin health and consequently
its appearance. A wide range of dietary supplements is offered to improve skin
health. Collagen peptides are used as a bioactive ingredient in nutricosmetic
products and have been shown in preclinical studies to improve skin barrier
function, to induce the synthesis of collagen and hyaluronic acid, and to
promote fibroblast growth and migration ... Oral collagen peptide
supplementation significantly increased skin hydration after 8 weeks of intake.
The collagen density in the dermis significantly increased and the fragmentation
of the dermal collagen network significantly decreased already after 4 weeks of
supplementation. Both effects persisted after 12 weeks. Ex vivo experiments
demonstrated that collagen peptides induce collagen as well as glycosaminoglycan
production, offering a mechanistic explanation for the observed clinical
effects" - [Nutra
USA] - See Protein Essentials Hydrolyzed Collagen Protein Powder with Peptan® (16oz)
at Amazon.com This is a neat gadget.
It’s a LCD arm. Not
only does it put my monitor in the perfect place but it makes cleaning
my desk a lot easier. It’s
got 5 stars with 537 reviews at Amazon, something you rarely see.
See: http://amzn.to/1VpmKbP
. After I bought it I
noticed that Amazon has what looks like the same thing under their brand
for $30 less: http://amzn.to/1RhLTPY
. Also there’s a wall
mounted model: http://amzn.to/1LSiA6k
Health Focus (Atherosclerosis):
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. It's
the Rousselot Peptan collagen brand talked about in the
