Recent Longevity News for the seven days ending 5/26/10.  You should consult your doctor if you are taking any medications.

15 best age-erasing superfoods - MSNBC, 5/25/10 - "Yogurt ... Various cultures claim yogurt as their own creation, but the 2,000-year-old food’s health benefits are not disputed: Fermentation spawns hundreds of millions of probiotic organisms that serve as reinforcements to the battalions of beneficial bacteria in your body, which keep your digestive tract healthy and your immune system in top form, and provide protection against cancer. Not all yogurts are probiotic, though, so make sure the label says “live and active cultures.”"

Top sunscreens? Consumer Reports ranks best - MSNBC, 5/25/10 - "The top 4 sunscreens rated by Consumer Reports, based on how well they protected against UVA and UVB rays while worn on volunteers who soaked in water for 40 or 80 minutes ... Up & Up Sport Continuous (Target) spray SPF 30 ... Walgreens Sport Continous spray SPF 50 ... Banana Boat Sport Performance Continuous spray SPF 30 ... Aveeno Continuous Protection spray SPF 50 .... And the lowest scoring sunscreens: La Roche-Posay Anthelios 40 with Mexoryl SX crea SPF 40 ($18.82 per ounce) ... Avon Skin-So-Soft Bug Guard Plus IR3535 Expedition pump spray SPF 30 (Doesn't block UVA rays) ... Burt's Bees Chemical-Free with Hemp Seed Oil lotion SPF 30 (Doesn't block entire UVA spectrum)"

More 'good' cholesterol is not always good for your health - Science Daily, 5/25/10 - "Patients in the high-risk subgroup were characterized as having high levels of C-reactive protein (CRP), a well-known marker of inflammation, in addition to high HDL cholesterol. Study authors believe genetics and environmental factors, particularly inflammation, influence whether high levels of HDL cholesterol are protective or if they increase cardiovascular risk in individual patients. Given an inflammatory environment, an individual's unique set of genes helps determine whether HDL cholesterol transforms from a good actor to a bad actor in the heart disease process"

Bacteria as a predicter of colorectal cancer - Science Daily, 5/25/10 - "Several bacterial signatures were detected only in subjects with polyps, others only in subjects without polyps. Eubacterium ramulus was increased in the stools of subjects with polyps while Ruminococcus sp and a human intestine firmicute were increased in subjects without polyps. In tissue samples, Acidovorax sp. was found more frequently in subjects with polyps. Other bacterial signatures that differed between cases and controls were observed but did not match any know bacteria, suggesting unidentified and uncharacterized bacteria are also present"

Folate prevents alcohol-induced congenital heart defects in mice, study finds - Science Daily, 5/24/10 - "A new animal study has found that high levels of the B-vitamin folate (folic acid) prevented heart birth defects induced by alcohol exposure in early pregnancy"

Drinking fewer sugar-sweetened beverages may lower blood pressure - Science Daily, 5/24/10 - ""Our findings suggest that reducing sugar-sweetened beverages and sugar consumption may be an important dietary strategy to lower blood pressure and further reduce other blood pressure-related diseases," Chen said. "It has been estimated that a 3-millimeters of mercury (mm Hg) reduction in systolic blood pressure should reduce stroke mortality by 8 percent and coronary heart disease mortality by 5 percent. Such reductions in systolic blood pressure would be anticipated by reducing sugar-sweetened beverages consumption by an average of 2 servings per day ... a reduction of one serving/day of SSB was associated with a 1.8 millimeters of mercury (mm Hg) drop in systolic pressure and a 1.1 mm Hg decline in diastolic pressure over 18 months"

Bilberry-pine bark mix shows eye health benefits - Nutra USA, 5/24/10 - "One group received daily Mirtogenol supplements (40 mg Pycnogenol, 80 mg Mirtoselect), one group received Latanoprost eye drops, and the third group received a combination of both ... After 24 weeks of intervention, the researchers noted a reduction of blood pressure in the eye from an average of 38.1 to 29.0 mmHg in the Mirtogenol group, from 37.7 to 27.2 mmHg in the Latanoprost group, and from 38.0 to 23.0 mmHg in the combined group. Normal eye pressure is reported to range from 10 to 21 mmHg"

Vitamin E may boost immune function: Mouse study - Science Daily, 5/20/10 - "The animals were fed 0.1 per cent Tocomin 50 per cent (Carotech), which is a mixture of tocotrienols and alpha-tocopherols, or a control diet containing only tocopherol, for six weeks ... Older mice fed the tocotrienol supplement displayed a greater level of lymphocyte proliferation, a marker of how quickly white blood cells can reproduce in response to infection, than old mice fed the control ... mice of both ages fed the tocotrienol supplement had higher levels of the interleukin-1beta, a cytokine released by immune cells (macrophages). ... There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the most common form in the American diet" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Abdominal fat at middle age associated with greater risk of dementia: Obesity linked to lower total brain volume - Science Daily, 5/20/10 - "excess abdominal fat places otherwise healthy, middle-aged people at risk for dementia later in life ... 24.3 million people have some form of dementia, with 4.6 million new cases annually"

Yogurt-like drink DanActive reduced rate of common infections in daycare children - Science Daily, 5/19/10 - "Researchers found a 19 percent decrease of common infections among the children who drank the yogurt-like drink with L. casei DN-114 001 compared to those whose drink did not have the probiotic. More specifically, those who drank DanActive had 24 percent fewer gastrointestinal infections (such as diarrhea, nausea, and vomiting), and 18 percent fewer upper respiratory tract infections (such as ear infections, sinusitis and strep). However, the reduction in infections did not result in fewer missed school days or activities -- also a primary outcome of the study" - [Abstract] - Note:  For what it's worth, I tried Activa in my yogurt maker and it worked fine however Activa has fruit mixed with it but most of it flouted to the top and I was able to skim it off.

Canned Food May Expose People to BPA - WebMD, 5/18/10 - "A study conducted by a coalition of consumer and food safety groups found detectable levels of BPA in 46 of 50 grocery store cans tested. The results suggest BPA routinely leaches from can linings into food ... The highest BPA level detected was 1,140 parts per billion, found in a can of Del Monte French Style Green Beans"

'Female Viagra' May Treat Low Sexual Desire - WebMD, 5/18/10 - "Flibanserin, an antidepressant-like drug, makes sex more satisfying for some premenopausal women distressed over their low sexual desire"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effect of dutasteride, tamsulosin and the combination on patient-reported quality of life and treatment satisfaction in men with moderate-to-severe benign prostatic hyperplasia: 4-year data from the CombAT study - Int J Clin Pract. 2010 May 7 - "Subjects were randomised to receive 0.5 mg dutasteride, 0.4 mg tamsulosin or the combination once daily for 4 years ... At 4 years, combination therapy resulted in significantly superior improvements from baseline in BII and IPSS Q8 than either monotherapy; these benefits were observed from 3 months onwards compared with dutasteride and from 9 months (BII) or 12 months (IPSS Q8) onwards compared with tamsulosin. Also at 4 years, the PPSM questionnaire showed that a significantly higher proportion of patients was satisfied with, and would request treatment with, combination therapy compared with either monotherapy. Conclusions: Combination therapy (dutasteride plus tamsulosin) provides significantly superior improvements in patient-reported quality of life and treatment satisfaction than either monotherapy at 4 years in men with moderate-to-severe BPH symptoms" - See dutasteride at OffshoreRx1.com.

Tea consumption and risk of ovarian cancer - Cancer Causes Control. 2010 May 20 - "We also systemically reviewed all the available evidence regarding the potential association between green tea and risk of ovarian cancer, given the abundance of bioavailable polyphenols and higher antioxidant capacity of green tea than black tea, to provide the best summary estimate of the association. RESULTS: In our case-control study, while we found uniformly inverse odds ratios (OR) for tea drinkers compared to non-tea drinkers [4 + cups/day any tea OR 0.71 (95% CI 0.52-0.97); green tea OR 0.82 (95% CI 0.38-1.79); herbal tea OR 0.77 (95% CI 0.28-2.14): black tea OR 0.88 (95% CI 0.66-1.18)], we saw no dose-response trends. Our meta-analysis provided some evidence that women who drink green tea have a lower risk of ovarian cancer, although the summary estimate did not reach statistical significance (0.58, 95% CI 0.33-1.01 for >/=1 cup/green tea day). This result is consistent with two recent meta-analyses that evaluated the association of tea (all types combined) and ovarian cancer risk" - See green tea extract at Amazon.com.

Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 - Br J Nutr. 2010 May 21:1-9 - "90 g yoghurt or drink 100 ml milk once per d over an 8- or 12-week period. A meta-analysis of the results of these two independent studies showed the risk of catching the common cold was about 2.6 times lower (OR 0.39; P = 0.019) in the yoghurt group than in the milk group and the increase of natural killer cell activity was significantly higher in the yoghurt group than in the milk group" - See Yogourmet Electric Yogurt Maker at Amazon.com.

Dietary zinc intake is inversely related to subclinical atherosclerosis measured by carotid intima-media thickness - Br J Nutr. 2010 May 21:1-10 - "After adjustment for potential confounders, the mean carotid IMT in the low Zn intake group was higher than that in the high Zn intake group. When subclinical atherosclerosis was defined as >80th percentile value of IMT or >/= 1 mm of carotid IMT, after adjustment for potential confounders, Zn intake was inversely related to subclinical atherosclerosis (5th v. 1st quintile, OR 0.64, 95 % CI 0.45, 0.90, P for trend = 0.069; 5th v. 1st quintile, OR 0.34, 95 % CI 0.16, 0.70, P for trend = 0.005, respectively). In persons free of clinical CVD, dietary Zn intake was inversely correlated with subclinical atherosclerosis. The present findings suggest a putative protective role of dietary Zn intake against the development of atherosclerosis" - See Jarrow Zinc Balance at Amazon.com (zinc supplementation can cause a copper deficiency.

Arterial Stiffness and Wave Reflections in Marathon Runners - Am J Hypertens. 2010 May 20 - "Marathon runners had significantly higher systolic, diastolic, pulse (both aortic and brachial), and mean pressures compared to controls (P < 0.05 for all). Marathon runners had significantly higher PWV (6.89 m/s vs. 6.33 m/s, P < 0.01), whereas there was no difference in AIx and AIx corrected for heart rate (AIx@75) compared to controls (13.8% vs. 13.9%, P = 0.985 and 8.2% vs. 10.3%, P = 0.340, respectively). Marathon race caused a significant fall in both AIx (12.2% vs. -5.8%, P < 0.001) and AIx@75 (7.0% vs. 0.0%, P = 0.01), whereas PWV did not change significantly (6.66 m/s vs. 6.74 m/s, P = 0.690). Aortic and brachial systolic, diastolic, and mean pressures were also decreased (P < 0.05).Conclusions A significant fall in wave reflections was observed after marathon race, whereas aortic stiffness was not altered. Moreover, marathon runners have increased aortic stiffness and pressures, whereas wave reflections indexes do not differ compared to controls"

Anti-atherogenic effects of resveratrol - Eur J Clin Nutr. 2010 May 19 - "RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates alpha-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD" - See resveratrol products at Amazon.com.

Neat Tech Stuff (normal size keyboard plus mouse support for iPad):

• Macally BTKey Wireless Bluetooth Keyboard for Mac and Macally Bluetooth Wireless Laser Mouse for Mac and PC
  1. Sync your iPad with iTunes
  2. Download and run Spirit jailbreak. You’ll see a dialog box on your PC wanting you to authorize the sync with Spirit. Approve it.
  3.  That will give you an icon on the iPad called Cydia. Select Cydia and search (search icon is on bottom right)  “BTStack” and load the BTStack keyboard package ($5) and the BTStack mouse.
  4. Click here for my video.
  5. References:
     1. iPad + Bluetooth keyboard + Bluetooth Mouse = Computer? - intomobile.com
     2. iPad, newer iPhones, hacked and jailbroken – Multitask on your iPad now! - intomobile.com
     3. BTstack Keyboard - ringwald.ch
     4. Using a Wireless Keyboard with an iPhone using BTstack Keyboard - tuaw.com
     5. How to Connect and Use a Bluetooth Keyboard With Your iPhone [BTstack] - iClarified

Health Focus (Insomnia):

Related Topics:

• sleep / sleep apnea / depression

Popular Medications:

• Sonata (zaleplon) / Ambien (zolpidem) / Estorra (eszopiclone/investigational) / Rozerem (ramelteon) / Remeron (mirtazapine) / trazodone

Popular Supplements:

• melatonin / 5-HTP / St. John's wort / valerian / lemon balm / chamomile / hops / passion flower / lavender / kava / Vitacost insomnia formulas / Alluna sleep store at drugstore.com / Sleep support formulas at iHerb / Seditol at iHerb

Alternative News:

• Insomnia and Daytime Sleepiness - Life Extension Foundation
• Jet Lag - Life Extension Foundation
• Insomnia - The Natural Pharmacist
• Insomnia Is Bad For The Heart; Increases Blood Pressure - Science Daily, 9/4/09 - "A new study published in the journal Sleep has found that people who suffer from insomnia have heightened nighttime blood pressure, which can lead to cardiac problems"
• Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? - Altern Ther Health Med. 2009 Mar-Apr;15(2):22-8 - "The results of this study suggest that the use of 800 mg of valerian for 8 weeks improves symptoms of RLS and decreases daytime sleepiness in patients that report an Epworth Sleepiness Scale (ESS) score of 10 or greater. Valerian may be an alternative treatment for the symptom management ofRLS with positive health outcomes and improved quality of life" - See valerian root at Amazon.com.
• Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes - Curr Med Res Opin. 2007 Sep 14 - "PR-melatonin results in significant and clinically meaningful improvements in sleep quality, morning alertness, sleep onset latency and quality of life in primary insomnia patients aged 55 years and over" - See melatonin at Amazon.com.
• Carbs May Help You Fall Asleep Faster - WebMD, 2/14/07 - "Carbs which quickly raise blood sugar (those with a high glycemic index) may hasten sleep, especially when eaten four hours before bedtime ... The men fell asleep fastest after eating the jasmine rice meal four hours before bedtime. It took them nine minutes, on average, to fall asleep that night ... They were slowest to fall asleep after eating the long-grain rice meal four hours before bedtime, taking nearly 18 minutes, on average, to fall asleep"
• Seditol helps sleepless in Cincinnati - Nutra USA, 6/15/06 - "Ninety-two percent of the subjects reported Seditol helped them relax and 89 percent reported it helped reduce fatigue due to lack of sleep" - See Seditol at iHerb.
• Stopping Jet Lag Before It Starts - WebMD, 11/2/05 - "The body clocks of those who took melatonin adapted better to the new schedule. The higher dose of melatonin fared best in that regard, but not by much. Plus, people who took the higher dose were sleepier in the evenings after taking the pill"
• Melatonin to Fight Insomnia: Timing Is Key - WebMD, 10/25/05 - "melatonin was most effective in resetting the body's internal, or circadian, clock when it was timed to the individual's sleep patterns ... If you only want to induce sleep you can take it about two hours before you want to go to sleep"
• Melatonin for Jet Lag and Sleep Disorders - Clinical Psychiatry News, 10/04 - "Those given melatonin reported improved sleep latency and morning “restedness,” and had higher scores on the California Verbal Learning Test" - See iHerb or Vitacost melatonin products.
• Short Insomnia Therapy Beats Sleeping Pills - WebMD, 9/27/04
• Sleep easy with green tea - Nutra USA, 3/16/04 - "200mg of L-theanine or a placebo ... all subjects reported a significant absence of feeling exhausted and a reduced need for sleep when administered with the L-theanine, compared to the placebo"
• Morning Exercise May Help You Sleep - WebMD, 11/4/03
• Sleep Problems, Anxiety May Be Connected - WebMD, 9/12/03 - "both sleep and mood problems may result from a lack of the same brain chemical ... The brain chemical -- gamma-aminobutryric acid, or GABA -- is involved in regulating brain activity ... Specifically, GABA deficiencies interfere with the most important stage of sleep -- the "deep" delta sleep" - See iHerb or Vitacost GABA products.
• Nighttime Computer Users May Lose Sleep - WebMD, 6/20/03 - "the bright light of a computer screen may alter the body's biological clock and suppress the natural production of melatonin that's critical to the normal sleep-wake cycle" - See iHerb or Vitacost melatonin products.
• Herbal With Valerian Helps Treat Sleep-Onset Insomnia - Clinical Psychiatry News, 5/03 - "Those who took the supplement experienced a significant decrease in subjective sleep latency from baseline of 12.61 minutes, according to daily sleep diaries. Patients taking the placebo experienced an average increase of 7.98 minutes in subjective sleep latency ... Blissful Sleep contains 160 mg of valerian and smaller amounts of Rosa centifolia, Nardostachys jatamansi, Tinospora cordifolia, Withania somnifera, Piper nigrum, Alpinia galangal, Convolvulus pluricalis, and Glycyrrhiza glabra" - See iHerb or Vitacost valerian products.  My favorite is Valerian Nighttime at iHerb.
• Melatonin Appears Safe for Child Insomniacs - Clinical Psychiatry News, 3/03 - "Melatonin appears to be a safe and effective treatment for children with insomnia ... The average age of the patients was 9.6 years ... Dr. Ivanenko, who is a child psychiatrist at the University of Louisville (Ky.), said she typically starts children at 1-5 mg of melatonin and titrates up to as much as 8-10 mg in adolescents" - See iHerb or Vitacost melatonin products.
• Is it is okay to take L-trypotophan that is a veterinary supplement? - Dr. Weil, 8/8/02
• 12 Tips for Better Sleep in Bad Times - WebMD, 10/4/01
• Valerian-Lemon Balm An Effective Combo - Nutrition Science News, 6/01
• Can't Sleep? Through Therapy, Insomnia Habits Can Be Broken - WebMD, 4/10/01
• Retiming Meals Could Help Reset Body Clock, Study Suggests - Intelihealth, 1/19/01
• When You Eat May Affect Your Biological Clock, New Research May Help Alleviate Jet Lag, Night-Shift Woes - WebMD, 1/18/01
• Setting the Body Clock in the Dark - WebMD, 10/12/00
• Some Herbs Work for Treating Sleep Problems; Others Don't - WebMD, 7/13/00
• Melatonin helps kids with sleep-onset insomnia - Doctor's Guide, 5/2/00
• Valerian Root Is a Safe Sedative - Nutrition Science News, 11/00
• Herbs Make It Easy to Catch Some Zs" - Nutrition Science News, 11/99

CME:

• Doctor's Guide Sleep Disorders CME courses
• Medscape insomnia CME courses
• Newer Options in the Management of Insomnia - PowerPak.com, exp., 10/07
• Pharmacologic Advances in the Treatment of Insomnia - Medscape, 7/28/05
• A Primary Care Approach to Insomnia Management - Medscape, exp. 1/31/05
• Current Perspectives in Insomnia, Volume 4 - Medscape, exp. 12/9/05
• Current Perspectives in Insomnia, Volume 2 - Medscape, exp. 8/12/05
• Interrelationships of Depression and Anxiety to Insomnia - Medscape, exp. 7/13/05
• Treatment of Insomnia - PowerPak.com, exp. 6/1/03

General Information:

• Insomnia - American Academy of Family Physicians
• Insomnia - emedicine.com
• Insomnia - FamilyDoctor.org
• Insomnia - Intelihealth
• Sleep Disorders - Veritas Medicine
• Treatments for sleep disorders - Medifocus.com

Other News:

• Middle-aged men: Could dwindling testosterone levels decrease sleep? - Science Daily, 5/14/10 - "In young men, deep sleep represents 10 to 20 percent of total sleep. By age 50, it decreases to five to seven percent. For men over 60, it can disappear altogether ... Because deep sleep requires great synchronization ... Low levels of testosterone intensify the lack of synchronization and can explain 20 percent of men's inability to experience deep sleep ... Sekerovic suggests dwindling testosterone levels are what impact sleep, not vice-versa, as other studies have suggested ... If Sekerovic is right, his findings could re-ignite the hormone therapy debate. "The loss of deep sleep is a serious problem that could be treated with testosterone. That would be tremendous progress,""
• Cognitive Behavior Therapy Appears Beneficial For Long-term Treatment Of Insomnia - Science Daily, 5/19/09
• Chronic Insomnia With Short Sleep Duration Is Significant Risk Factor For Hypertension - Science Daily, 4/9/09 - "participants with insomnia and an objectively measured, severely short sleep duration of less than five hours had a risk for hypertension that was 500 percent higher than participants without insomnia who slept more than six hours. People with insomnia and a moderately short sleep duration of five to six hours had a risk for hypertension that was 350 percent higher than normal sleepers"
• Chronic Insomnia With Short Sleep Duration Is Significant Risk Factor For Hypertension - Science Daily, 4/1/09 - "A study in the April 1 issue of the journal SLEEP is the first to demonstrate that chronic insomnia with objectively measured short sleep time is an independent and clinically significant risk factor for hypertension"
• Societal, Economic Burden Of Insomnia Is High - Science Daily, 1/1/09
• Worst Menopause Symptom? Lack of Sleep - WebMD, 4/22/08
• Altered Sex Hormone Levels, Higher Body Temp Affects Sleep Quality In Postmenopausal Women - Science Daily, 12/1/07 - "lower estradiol (E2) and higher luteinizing hormone (LH) levels were significantly correlated with indices of poor sleep quality, with relationships between LH and quality of sleep being stronger than those for E2"
• Cholesterol-lowering Drug Linked To Sleep Disruptions - Science Daily, 11/7/07 - "The results showed that simvastain use was associated with significantly worse sleep quality. A significantly greater number of individuals taking simvastatin reported sleep problems than those taking either pravastain or the placebo"
• Cholesterol Drug May Affect Sleep - WebMD, 11/7/07
• Sleep Drugs Found Only Mildly Effective, but Wildly Popular - New York Times, 10/23/07
• Chronic Insomnia May Predict Anxiety Disorders - WebMD, 7/5/07 - "People with chronic insomnia were more likely to have current anxiety or depression than people without insomnia"
• Long-term Pharmacologic Management of Insomnia - Medscape, 9/7/06
• New Sleep Medication Shows Less Potential to Foster Abuse and Dependence - Doctor's Guide, 6/6/06
• Sleep Drugs: None Stands Out as Best - WebMD, 12/9/05
• Treating Nighttime Heartburn Improves Sleep and Boosts Quality Of Life - Doctor's Guide, 9/2/05
• Poor Sleep Not A Normal Part Of Aging - Science Daily, 7/15/05
• Insomnia May Precede And Prolong Major Depression - Doctor's Guide, 6/22/05 - "depressed patients with insomnia were nearly 11 times more likely to still be depressed at six months than those sleeping well, and 17 times more likely to remain ill after a year ... they suggest that targeted treatment for insomnia will increase the likelihood and speed of recovery from depression"
• Good Night's Sleep Eludes Most Americans - WebMD, 3/29/05
• New Insights on Anxiety, Sleep Disorders - WebMD, 8/18/04
• The Evaluation and Management of the Anxious Insomniac - Medscape, 3/2/04
• Nightcaps May Disrupt Sleep - WebMD, 8/15/03
• New Insomnia Treatments Found Effective - WebMD, 6/10/03 - "Two new drugs have been found effective in treating insomnia with few or no side effects ... The first treatment, an experimental drug called TAK-375 ... [Estorra] demonstrated sustained therapeutic effect for the full twelve months of this study"
• New Drugs for Chronic Insomnia - Medscape, 5/27/03 - "Eszopiclone has beneficial effects on falling asleep, staying asleep, and quality of sleep"
• What You Can Do to Avoid Sleep Problems in Hard Times - WebMD, 4/3/03
• Don't Fear Benzodiazepines for Sleep Problems - Clinical Psychiatry News, 4/03 - "There is not one shred of evidence that Benadryl is an effective sleep-inducing agent ... It makes people feel sleepy, but it has no effect on sleep. And the reason we prescribe it is because we are afraid of using the medications that do work"
• Sleep Problems Don't Discriminate by Age - WebMD, 3/31/03 - "Sleep disorders were reported by: ... 82% of those with depression"
• Insomnia Often Associated With Objective Daytime Changes - Doctor's Guide, 2/14/03
• Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions, and psychomotor performance - J Clin Psychopharmacol 2002 Dec;22(6):576-83 - "Zaleplon 10 and 20 mg did not significantly impair driving ability 4 hours after middle-of-the-night administration. Relative to placebo, after zolpidem 10 mg, SDLP was significantly elevated, but the magnitude of the difference was small and not likely to be of clinical importance. Memory and psychomotor test performance was unaffected after both doses of zaleplon and zolpidem 10 mg. In contrast, zolpidem 20 mg significantly increased SDLP and speed variability. Further, zolpidem 20 mg significantly impaired performance on all psychomotor and memory tests ... The results show that zaleplon (10 and 20 mg) is a safe hypnotic devoid of next-morning residual impairment when used in the middle of the night"
• Physicians, Elderly Patients View Long-Term Benzodiazepine Use Differently - Doctor's Guide, 6/7/02
• "As Needed" Zolpidem and Behavioral Therapy Safely Treats Chronic Insomnia - Doctor's Guide, 5/6/02
• Behavior Management Programs Help Seniors With Chronic Illnesses Sleep Better - Doctor's Guide, 4/4/02
• Sleep experts put readers' questions, fears to rest - USA Today, 4/3/02
• Simple Steps Can Combat Sleep Problems in Elderly - WebMD, 1/2/02
• Recent Events May Affect Sleep, Tips to Fight Insomnia, Nightmares in Children - WebMD, 9/19/01
• Mirtazapine Regulates Stress Hormones, Improves Sleep In Depressed Patients - Doctor's Guide, 8/8/01
• Gaboxadol Improves Sleep in Elderly - Doctor's Guide, 6/11/01
• Sleep Disorder Diagnosis Can Be Done Effectively at Home - Doctor's Guide, 6/11/01
• “Nightcap” Device Provides Simple, Home-based Assessment of Insomnia - Doctor's Guide, 6/8/01
• New Guidelines Issued For Improvement Of Insomnia Diagnosis, Treatment - Doctor's Guide, 3/6/01
• Insomnia Underdiagnosed And Undertreated - Doctor's Guide, 2/23/01
• Micro Form Of Progestogen Replacement May Improve Sleep Symptoms - Doctor's Guide, 2/14/01 - "Women who take a combined form of hormone replacement therapy with a new kind of progestogen sleep more soundly"
• Low-Dose Sedating Antidepressant Or Hypnotic May Improve Insomnia Management In Depressed Patients - Doctor's Guide, 6/19/00
• Sleep Disturbances Found In Patients Taking Common Hepatitis C Treatment - Doctor's Guide, 6/19/00
• Benefits Of Zaleplon For Primary Insomnia Maintained Over Time - Doctor's Guide, 6/19/00
• New medications relieve insomnia without the hangover - Intelihealth, 5/31/00
• New Insomnia Drug, NBI-34060, Shows Positive Results For Sleep Induction - Doctor's Guide, 11/30/99
• Zaleplon Safe And Well Tolerated For Long-Term Insomnia Treatment - Doctor's Guide, 9/29/99
• New Sleeping Pill Hailed As Businessman’s Friend - Doctor's Guide, 9/23/99
• Zaleplon Safe And Tolerable For Long-Term Treatment Of Insomnia - Doctor's Guide, 9/21/99
• Majority Of Patients With Insomnia Diagnosed With Mental Disorder - Doctor's Guide, 9/14/99 - "A new study by Washington State University researchers reveals that among patients seeking medical care for insomnia more than half were diagnosed with a mental disorder. The most common diagnosis was depression"
• Strategies Improve Quality Of Life In People With Insomnia - Doctor's Guide, 9/8/99
• FDA Approves Sonata For Treatment Of Insomnia - Doctor's Guide, 8/16/99
• Sleepless in America - CNN, 6/1/99
• Zaleplon Effective Against Insomnia Without Residual Effects - Doctor's Guide, 5/17/99
• Cognitive-Behaviour Therapy And Drug Treatments Effective In Treating Late-Life Insomnia - Doctor's Guide, 3/16/99
• Most MDs Overprescribe Sleep Medications, Says Expert - Doctor's Guide, 10/7/97
• Importance of Proper Diagnosis Of Chronic Insomnia Stressed - Doctor's Guide, 1/29/97

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