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Anti-aging Research > Urolithin A
Urolithin A
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Urolithin A - Wiki -
"Pomegranate fruits, walnuts or raspberries are sources of
ellagitannins.[4][5][6] Ellagitannins are hydrolyzed in the
gut to release ellagic acid, which is further processed by
the gut microflora into urolithins through the loss of one
of its two lactones and by successive removal of hydroxyl
groups ... While studies have shown that Gordonibacter
urolithinfaciens and Gordonibacter pamelaeae play a role in
the conversion of ellagic acids and ellagitannins into
urolithin A, the microorganisms responsible for the complete
transformation into the final urolithins are still
unknown.[3] The efficiency of the conversion of
ellagitannins into urolithin A significantly varies in
humans, and some individuals do not show any conversion"
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Urolithin A attenuates
diabetes-associated cognitive impairment by ameliorating intestinal barrier
dysfunction via N-glycan biosynthesis pathway - Mol Nutr Food Res 2022 Feb
20 - "This study aimed to investigate the effect of
Urolithin A (UA) on diabetes-associated cognitive impairment in type 2 diabetes
mellitus (T2DM) mouse model induced by high-fat diet (HFD) and streptozotocin
(STZ) ... Although UA shares similar beneficial effects on diabetes with
metformin, unlike metformin, the effect of UA is independent of gut microbiome
and short chain fatty acids. Taken together, these data suggested that feeding
UA can attenuate diabetes-associated cognitive impairment by ameliorating
systemic inflammation and intestinal barrier dysfunction via N-glycan
biosynthesis pathway. The study implied UA as a potential novel pharmaceutic
target for diabetes therapy via manipulating gut-brain axis and N-glycan
metabolism" - See
urolithin a supplement at Amazon.com.
- Urolithin A
alleviates acute kidney injury induced by renal ischemia reperfusion through
the p62-Keap1-Nrf2 signaling pathway - Phytother Res 2022 Jan 17 -
"Acute kidney injury (AKI) induced by renal ischemia reperfusion (RIR) is
typically observed in renal surgeries and is a leading cause of renal
failure ... Herein, we report the effect of Urolithin A (UA) in a mouse RIR
model, wherein we demonstrated its underlying mechanism both in vitro and in
vivo. The expression levels of p62 and Keap1 significantly decreased, while
that of nuclear Nrf2 increased in vitro in a hypoxia cell model after UA
treatment. Furthermore, the apoptosis of tubular cells was attenuated and
the reactive oxygen species (ROS) levels were reduced in the kidneys in a
mouse RIR model after UA administration. In this study, we demonstrated that
UA can alleviate oxidative stress and promote autophagy by activating the
p62-Keap1-Nrf2 signaling pathway, which could protect the kidneys from
ischemia reperfusion injury."
- Urolithin A protects
dopaminergic neurons in experimental models of Parkinson's disease by
promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling
pathway - Food Funct 2021 Dec 14 -
"Mitochondrial dysfunction contributes to the pathogenesis of
neurodegenerative diseases such as Parkinson's disease (PD). Therapeutic
strategies targeting mitochondrial dysfunction hold considerable promise for
the treatment of PD. Recent reports have highlighted the protective role of
urolithin A (UA), a gut metabolite produced from ellagic acid-containing
foods such as pomegranates, berries and walnuts, in several neurological
disorders including Alzheimer's disease and ischemic stroke ... Our results
revealed that UA protected against 6-OHDA cytotoxicity and apoptosis in PC12
cells. Meanwhile, administration of UA to 6-OHDA lesioned mice ameliorated
both motor deficits and nigral-striatal dopaminergic neurotoxicity. More
important, UA treatment significantly attenuated 6-OHDA-induced
mitochondrial dysfunction in PC12 cells accompanied by enhanced
mitochondrial biogenesis. Mechanistically, we demonstrated that UA exerts
neuroprotective effects by promoting mitochondrial biogenesis via
SIRT1-PGC-1α signaling pathway. Taken together, these data provide new
insights into the novel role of UA in regulating mitochondrial dysfunction
and suggest that UA may have potential therapeutic applications for PD"
- See urolithin a supplement at Amazon.com.
Abstracts:
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Urolithin A Attenuates
Helicobacter pylori-Induced Damage In Vivo - J Agric Food Chem 2022 Sep 15 -
"Urolithin A (UA) is a metabolite produced in the gut
following the consumption of ellagic acid (EA) rich foods. EA has shown
anti-inflammatory, antioxidant, and anticancer properties. Because EA is poorly
absorbed in the gastrointestinal tract, urolithins are considered to play a
major role in bioactivity. Helicobacter pylori (H. pylori) infection is the most
common chronic bacterial infection all over the world. It is potentially
hazardous to humans because of its relationship to various gastrointestinal
diseases. In this study, we investigated the effect of UA on inflammation by H.
pylori. The results indicated that UA attenuated H. pylori-induced inflammation
in vitro and in vivo. UA also reduced the secretion of H. pylori virulence
factors and tissue injuries in mice. Furthermore, UA decreased the relative
abundance of Helicobacteraceae in feces of H. pylori-infected mice. In summary,
taking UA effectively inhibited the injury caused by H. pylori" - See
urolithin a supplement at Amazon.com.
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Urolithin A improves mitochondrial health, reduces cartilage
degeneration, and alleviates pain in osteoarthritis -
Aging Cell 2022 Jul 1 - "Urolithin A
(Mitopure) is a natural postbiotic compound that promotes
mitophagy and mitochondrial function and beneficially
impacts muscle health in preclinical models of aging and in
elderly and middle-aged humans. Here, we showed that
Urolithin A improved mitophagy and mitochondrial respiration
in primary chondrocytes from joints of both healthy donors
and OA patients. Furthermore, Urolithin A reduced disease
progression in a mouse model of OA, decreasing cartilage
degeneration, synovial inflammation, and pain. These
improvements were associated with increased mitophagy and
mitochondrial content, in joints of OA mice. These findings
indicate that UA promotes joint mitochondrial health,
alleviates OA pathology, and supports Urolithin A's
potential to improve mobility with beneficial effects on
structural damage in joints"
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Urolithin A ameliorates diabetic retinopathy via activation
of the Nrf2/HO-1 pathway - Endocr J 2022 Mar 24 -
"UA can ameliorate DR by repressing
inflammation and oxidative stress via the Nrf2/HO-1 pathway,
which suggests that UA could be an effective drug for
clinical DR treatment"
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