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Strawberry & Fisetin

Recommendations:

• Fisetin at Amazon.com
• Strawberry powder at Amazon.com.

News & Research:

• Researchers have discovered how to slow aging - Science Daily, 10/2/18 - "They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan ... Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan ... These results suggest that we can extend the period of health, termed healthspan, even towards the end of life" - See fisetin at Amazon.com.
  • Fisetin: A Dietary Antioxidant for Health Promotion - Antioxid Redox Signal. 2013 Jul 10; 19(2): 151–162 - "The highest concentration of fisetin was found in strawberries (160 μg/g) followed by apple (26.9 μg/g) and persimmon (10.5 μg/g) (33)"
• Strawberries could help reduce harmful inflammation in the colon - Science Daily, 8/20/18 - "The sedentary lifestyle and dietary habits of many people in this country -- high-sugar, high-animal-fat, but low-fiber diets -- may promote colonic inflammation and increase the risk of IBD ... The researchers found that dietary consumption of whole strawberries at a dose equivalent to as low as three-quarters of a cup of strawberries per day in humans significantly suppressed symptoms like body weight loss and bloody diarrhea in mice with IBD. Strawberry treatments also diminished inflammatory responses in the mice's colonic tissue ... But decreased inflammation wasn't the strawberry's only conferred benefit during this study. Colonic inflammation adversely impacts the composition of microbiota in the gut. With IBD, the abundance of harmful bacteria increases, while levels of beneficial bacteria decrease in the colon. Following the dietary treatments of whole strawberries, the researchers observed a reversal of that unhealthy microbiota composition in the IBD mice"
• Natural plant compound may reduce mental effects of aging, more evidence shows - Science Daily, 7/10/17 - "At 10 months, the differences between these two groups were striking ... Mice not treated with fisetin had difficulties with all the cognitive tests as well as elevated markers of stress and inflammation. Brain cells called astrocytes and microglia, which are normally anti-inflammatory, were now driving rampant inflammation. Mice treated with fisetin, on the other hand, were not noticeably different in behavior, cognitive ability or inflammatory markers at 10 months than a group of untreated 3-month-old mice with the same condition. Additionally, the team found no evidence of acute toxicity in the fisetin-treated mice, even at high doses of the compound" - See fisetin at Amazon.com.
• Study on mice demonstrates the action of strawberries against breast cancer - Science Daily, 4/19/17 - "strawberry extract can inhibit the spread of laboratory-grown breast cancer cells, even when they are inoculated in female mice to induce tumors ... It was also shown that strawberry extract reduced the expression of several genes involved in the processes of invasion and metastasis, such as Csf1, Mcam, Nr4a3 and Set. The extract simultaneously stimulated expression of the gene Htatip2, which is thought to suppress metastasis to the lymphatic ganglion in breast cancer patients"
• New MIND diet may significantly protect against Alzheimer’s disease - Science Daily, 3/23/15 - "With the MIND diet, a person who eats at least three servings of whole grains, a salad and one other vegetable every day -- along with a glass of wine -- snacks most days on nuts, has beans every other day or so, eats poultry and berries at least twice a week and fish at least once a week and benefits. However, he or she must limits intake of the designated unhealthy foods, especially butter (less than 1 tablespoon a day), cheese, and fried or fast food (less than a serving a week for any of the three), to have a real shot at avoiding the devastating effects of AD ... Blueberries are one of the more potent foods in terms of protecting the brain ... strawberries have also performed well in past studies of the effect of food on cognitive function"
• Strawberries lower cholesterol, study suggests - Science Daily, 2/25/14 - "The team set up an experiment in which they added 500 g of strawberries to the daily diets of 23 healthy volunteers over a month ... the total amount of cholesterol, the levels of low-density lipoproteins (LDL or bad cholesterol) and the quantity of triglycerides fell to 8.78%, 13.72% and 20.8% respectively. The high-density lipoprotein (HDL or good cholesterol) remained unchanged" - Note: 500 grams of strawberries is 18 ounces or 1.1 pounds or about 3/4th of a quart.
• Natural plant compound prevents Alzheimer's disease in mice - Science Daily, 1/27/14 - "A chemical that's found in fruits and vegetables from strawberries to cucumbers appears to stop memory loss that accompanies Alzheimer's disease in mice ... In experiments on mice that normally develop Alzheimer's symptoms less than a year after birth, a daily dose of the compound -- -a flavonol called fisetin -- -prevented the progressive memory and learning impairments" - See fisetin at Amazon.com.
• 5 Foods for Healthy Skin - ABC News, 9/12/13 - "Strawberries ... Olive oil ... Green tea ... Pumpkin ... Pomegranate"
• Strawberries, blueberries may cut heart attack risk in women - Science Daily, 1/14/13 - "Blueberries and strawberries contain high levels of naturally occurring compounds called dietary flavonoids, also found in grapes and wine, blackberries, eggplant, and other fruits and vegetables. A specific sub-class of flavonoids, called anthocyanins, may help dilate arteries, counter the buildup of plaque and provide other cardiovascular benefits ... Nurses' Health Study II ... women completed questionnaires about their diet every four years for 18 years ... Women who ate the most blueberries and strawberries had a 32-percent reduction in their risk of heart attack compared to women who ate the berries once a month or less" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
• Strawberry extract protects against UVA rays, study suggests - Science Daily, 8/3/12 - "The team prepared human skin cell cultures (fibroblasts) and added strawberry extract in different concentrations (0.05, 0.25 and 0.5 mg/ml), the only exception being the control extract. Using ultraviolet light, the samples were then exposed to a dose "equivalent to 90 minutes of midday summer sun in the French Riviera." ... the strawberry extract, especially at a concentration of 0.5 mg/ml, displays photoprotective properties in those fibroblasts exposed to UVA radiation, it increases cell survival and viability and decreases damage in the DNA when compared with control cells ... But what molecules give strawberries their photoprotective properties? Scientists suspect that it could be the anthocyanins, which are pigments that give leaves, flowers and fruits their red colour" - See blueberry extract at Amazon.com.
• Eating more berries may reduce cognitive decline in the elderly - Science Daily, 4/26/12 - "The research team used data from the Nurses' Health Study -- a cohort of 121,700 female, registered nurses between the ages of 30 and 55 who completed health and lifestyle questionnaires beginning in 1976 ... increased consumption of blueberries and strawberries appear to slow cognitive decline in older women. A greater intake of anthocyanidins and total flavonoids was also associated with reduce cognitive degeneration. Researchers observed that women who had higher berry intake delayed cognitive aging by up to 2.5 years ... while they did control for other health factors in the modeling, they cannot rule out the possibility that the preserved cognition in those who eat more berries may be also influenced by other lifestyle choices, such as exercising more" - See blueberry extract at Amazon.com.
• Eating flavonoids protects men against Parkinson's disease, study finds - Science Daily, 4/4/12 - "This latest study is the first study in humans to show that flavonoids can protect neurons against diseases of the brain such as Parkinson's ... male participants who ate the most flavonoids were shown to be 40 per cent less likely to develop the disease than those who ate the least. No similar link was found for total flavonoid intake in women ... a sub-class of flavonoids called anthocyanins may have neuroprotective effects ... In this study the main protective effect was from higher intake of anthocyanins, which are present in berries and other fruits and vegetables including aubergines, blackcurrants and blackberries. Those who consumed the most anthocyanins had a 24 per cent reduction in risk of developing Parkinson's disease and strawberries and blueberries were the top two sources in the US diet"
• Eating berries benefits the brain - Science Daily, 3/7/12 - "blueberries, blackberries, strawberries and other berry fruits ... berry fruits help the brain stay healthy in several ways. Berry fruits contain high levels of antioxidants, compounds that protect cells from damage by harmful free radicals ... berry fruits change the way neurons in the brain communicate. These changes in signaling can prevent inflammation in the brain that contribute to neuronal damage and improve both motor control and cognition"
• Strawberry extracts as good as the whole food, suggests study - Nutra USA, 1/2/12
• It's not an apple a day after all -- it's strawberries: Flavonoids could represent two-fisted assault on diabetes and nervous system disorders - Science Daily, 6/27/11 - "fisetin, a naturally-occurring flavonoid found most abundantly in strawberries and to a lesser extent in other fruits and vegetables, lessens complications of diabetes. Previously, the lab showed that fisetin promoted survival of neurons grown in culture and enhanced memory in healthy mice ... Mice fed a fisetin-enriched diet remained diabetic, but acute kidney enlargement-or hypertrophy-seen in untreated mice was reversed, and high urine protein levels, a sure sign of kidney disease, fell. Moreover, fisetin ingestion ameliorated anxiety-related behaviors seen in diabetic mice ... blood and brain levels of sugars affixed to proteins known as advanced glycation end-products-or AGEs-were reduced in fisetin-treated compared to untreated Akita mice. These decreases were accompanied by increased activity of the enzyme glyoxalase 1, which promotes removal of toxic AGE precursors ... substantial evidence implicates high blood AGE levels with many if not most diabetic complications ... excessively high AGE levels also correlate with inflammatory activity thought to promote some cancers. In fact, studies published by others confirm that fisetin decreases tumorigenicity of prostate cancer cells both in culture and in animal models ... humans would have to eat 37 strawberries a day ... Rather than through diet, Maher envisions that fisetin-like drugs could be taken as a supplement"
• Strawberries boost red blood cells - Science Daily, 6/21/11 - "The body has an extensive arsenal of very diverse antioxidant mechanisms, which act at different levels. These can be cellular tools that repair oxidised genetic material, or molecules that are either manufactured by the body itself or consumed through the diet, which neutralise free radicals. Strawberries contain a large amount of phenolic compounds, such as flavonoids, which have antioxidant properties ... These substances reduce oxidative stress, an imbalance that occurs in certain pathologies, (such as cardiovascular disease, cancer and diabetes) and physiological situations (birth, aging, physical exercise), as well as in the battles between "reactive kinds of oxygen" -- in particular free radicals -- and the body's antioxidant defences ... When the level of oxidation exceeds these antioxidant defences, oxidative stress occurs. Aside from causing certain illnesses, this is also implicated in phenomena such as the speed at which we may age, for example"
• Strawberries may slow precancerous growth in the esophagus, study suggests - Science Daily, 4/6/11 - "freeze-dried strawberries significantly inhibited tumor development in the esophagus of rats ... daily consumption of strawberries suppressed various biomarkers involved in esophageal carcinogenesis, including cell proliferation, inflammation and gene transcription ... Each of the 36 study participants ate 60 grams (about two ounces) of freeze-dried strawberries daily for six months. The researchers obtained biopsy specimens before and after the strawberry consumption. The results showed that 29 out of 36 participants experienced a decrease in histological grade of the precancerous lesions during the study ... The survival rate of this type of esophageal cancer is very low, with only 10 percent of patients living 5 years after diagnosis"

Abstracts:

• Randomized Double-Blind Controlled Trial of Freeze-Dried Strawberry Powder Supplementation in Adults with Overweight or Obesity and Elevated Cholesterol - J Am Nutr Assoc 2022 Feb 23 - "Low-dose supplementation with freeze-dried strawberry powder, equivalent to ∼1 serving/day of fresh strawberries, improved cholesterol in adults with overweight or obesity, compared to both the high-dose (∼3 servings/day of fresh strawberries) and control, but did not alter other markers of CVD" - [Nutra USA] - See strawberry powder at Amazon.com.
• Effects of strawberries on bone biomarkers in pre- and stage 1-hypertensive postmenopausal women: a secondary analysis - Food Funct 2021 Dec 13 - "Postmenopausal women experience an increase in bone remodeling with the rate of bone resorption superseding the rate of bone formation. This results in a net bone loss with a subsequent increased risk for osteoporosis and fractures. High blood pressure (BP) has been associated with loss of bone mineral density and increased propensity to fractures. Strawberries are rich in polyphenols, which have been shown to have anti-hypertensive and bone-protective properties ... Participants (age: 59 ± 6 years; body mass index: 31.5 ± 4.1 kg m-2; systolic BP: 140 ± 13 mmHg) were randomly assigned to consume (1) 50 g of freeze-dried strawberry powder (FDSP), (2) 25 g FDSP + 25 g of placebo powder, or (3) 50 g placebo powder for eight weeks. Results indicate a significant time-by-treatment interaction (P = 0.04) for serum insulin-like growth factor (IGF)-1, a hormone that plays a major role in bone formation. Serum concentrations of bone-specific alkaline phosphatase, a marker of bone formation, and tartrate-resistant acid phosphatase-5b, a specific marker of bone resorption, were not affected by FDSP compared to placebo. Although not statistically significant, after eight weeks, osteocalcin increased in the 50 g FDSP group with a large effect size (d = 0.6) when compared to the placebo-control group. Adiponectin increased by 5% and 6% in the 25 g and 50 g FDSP groups, respectively, while it declined in the placebo-control group by 25% (P = 0.03 for time-by-treatment interaction). Our findings suggest that consumption of 25 g FDSP increases IGF-1 in postmenopausal women with pre- and stage 1-hypertension"
• Strawberry fruit (Fragaria x ananassa Romina) juice attenuates oxidative imbalance with concomitant modulation of metabolic indices linked to male infertility in testicular oxidative injury - Andrologia 2021 Jul 13 - "High-performance liquid chromatography analysis of SFE revealed the presence of rutin, caffeic acid, p-coumarin and cinnamic acid. These data imply the protective potentials of strawberry fruits against testicular oxidative injury"
• Dietary Strawberries Improve Cardiometabolic Risks in Adults with Obesity and Elevated Serum LDL Cholesterol in a Randomized Controlled Crossover Trial - Nutrients 2021, 13(5) - "participants were assigned to one of the three arms for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or two-and-a -half servings (high dose: 32 g strawberry powder/day) ... Findings revealed significant reductions in fasting insulin (p = 0.0002) and homeostatic model of assessment of insulin resistance (p = 0.0003) following the high dose strawberry phase when compared to the low dose strawberry and control phases. Glucose and conventional lipid profiles did not differ among the phases. Nuclear magnetic resonance-determined particle concentrations of total VLDL and chylomicrons, small VLDL, and total and small LDL were significantly decreased after the high dose strawberry phase, compared to control and low dose phases (all p < 0.0001). Among the biomarkers of inflammation and adipokines measured, only serum PAI-1 showed a decrease after the high dose strawberry phase (p = 0.002). Conclusions: These data suggest that consuming strawberries at two-and-a-half servings for four weeks significantly improves insulin resistance, lipid particle profiles, and serum PAI-1 in obese adults with elevated serum LDL-C" - [Nutra USA] - See strawberry powder at Amazon.com.
• Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk - Nutrients. 2019 Dec 14;11(12) - "A total of 245 participants developed Alzheimer's dementia over the mean follow-up of 6.7 (±3.6) years. Higher strawberry intake was associated with reduced risk of Alzheimer's dementia (HR = 0.76, 95% CI: 0.60-0.96). In separate adjusted models, highest vs. lowest quartile intakes of Vitamin C (HR = 0.64, 95% CI: 0.45, 0.92), Pelargonidin (0.63, 95% CI: 0.43, 0.92), total anthocyanidins (0.69, 95% CI: 0.48, 0.99), and total flavonoids (0.67, 95% CI: 0.46, 0.98) were each associated with lower Alzheimer's dementia risk" - See fisetin at Amazon.com.
• Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial - Br J Nutr. 2017 Mar 14:1-13 - "Plant-derived foods rich in polyphenols are associated with several cardiometabolic health benefits, such as reduced postprandial hyperglycaemia ... strawberry and cranberry polyphenols (SCP) ... A 6-week dietary intervention with 333 mg of polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects but was not effective in improving other cardiometabolic risk factors"
• The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing - Br J Nutr. 2015 Sep 22:1-8 - "Previously, it has been shown that strawberry (SB) or blueberry (BB) supplementations, when fed to rats from 19 to 21 months of age, reverse age-related decrements in motor and cognitive performance ... rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory. In addition, the rats supplemented with BB and SB diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1, although the improvements in working memory performance could not solely be explained by these increases. The diverse polyphenolics in these berry fruits may have additional mechanisms of action that could account for their relative differences in efficacy" - [Nutra USA] - See blueberry extract at Amazon.com.
• Strawberry and Human Health: Effects Beyond Antioxidant Activity - J Agric Food Chem. 2014 Jan 23 - "The strawberry (Fragaria X ananassa,Duch.) possesses a remarkable nutritional composition in terms of micronutrients such as minerals, vitamin C and folates, and non nutrient elements, like phenolic compounds, that are essential for human health. Although strawberry phenolics are known mainly for their anti-inflammatory and antioxidant action, recent studies have demonstrated that their biological activities also spread to other pathways involved in cellular metabolism and cellular survival" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
• Effects of Freeze-Dried Strawberry Supplementation on Metabolic Biomarkers of Atherosclerosis in Subjects with Type 2 Diabetes: A Randomized Double-Blind Controlled Trial - Ann Nutr Metab. 2013 Dec 6;63(3):256-264 - "To our knowledge there has been no study investigating the impact of freeze-dried strawberry (FDS) supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes (T2D) ... Thirty-six subjects with T2D (23 females; mean body mass index 27.90 ± 3.7; mean age 51.57 ± 10 years) were randomly divided into two groups. The treatment group consumed 2 cups of FDS beverage (50 g of FDS is equivalent to 500 g of fresh strawberries) or macronutrient matched placebo powder with strawberry flavor daily for 6 weeks in a randomized double-blind controlled trial ... FDS supplementation significantly decreased C-reactive protein levels as a biomarker of inflammation (2.5 vs. 2.04 mg/l, p < 0.05) and lipid peroxidation in the form of MDA (3.36 vs. 2.7 nmol/ml, p < 0.05) at 6 weeks compared to the baseline. Moreover, supplementation led to a decreasing trend in HbA1c (-5.7%, p < 0.05) and significant increase in total antioxidant status in the FDS group (1.44 vs. 1.26 mmol/l, p < 0.01) compared to the placebo group"
• High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women - Circulation. 2013 Jan 15 - "We followed up 93 600 women 25 to 42 years of age from the Nurses' Health Study (NHS) II who were healthy at baseline (1989) to examine the relationship between anthocyanins and other flavonoids and the risk of MI. Intake of flavonoid subclasses was calculated from validated food-frequency questionnaires ... An inverse association between higher intake of anthocyanins and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval, 0.49-0.96; P=0.03, highest versus lowest quintiles) after multivariate adjustment ... Combined intake of 2 anthocyanin-rich foods, blueberries and strawberries, tended to be associated with a decreased risk of MI (hazard ratio, 0.66; 95% confidence interval, 0.40-1.08) in a comparison of those consuming >3 servings a week and those with lower intake. Intakes of other flavonoid subclasses were not significantly associated with MI risk"
• Strawberry anthocyanin and its association with postprandial inflammation and insulin - Br J Nutr. 2011 May 16:1-10 - "moderate-fat meal (HCFM) ... The postprandial concentrations of pelargonidin sulfate and pelargonidin-3-O-glucoside were significantly increased when the strawberry beverage was consumed concurrently with the HCFM compared with the placebo beverage (P < 0.001). The strawberry beverage significantly attenuated the postprandial inflammatory response as measured by high-sensitivity C-reactive protein and IL-6 (P < 0.05) induced by the HCFM. It was also associated with a reduction in postprandial insulin response (P < 0.05). Collectively, these data provide evidence for favourable effects of strawberry antioxidants on postprandial inflammation and insulin sensitivity"