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Home > Health Conditions > PCOS

Polycystic Ovary Syndrome (PCOS)

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  • Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice - Endocr J. 2019 Jul 3 - "Mice were divided into 4 groups: control group (CON), model group (MOD), inulin group (INU), metformin group (MET). The last three groups were fed 6 mg of dehydroepiandrosterone (DHEA) per 100 g body weight and 60% high-fat diet to generate mice model. After 21 days of intervention, mice were euthanized and associated indications were investigated. Body weight (BW) and testosterone (T) levels were significantly decreased, but estradiol (E2) levels were increased in INU or MET group, respectively. Ovary HE staining demonstrated that inulin or metformin ameliorated PCOS morphology. Inflammatory indicators from plasma and ovary including TNF-α, IL-6, and IL-17A were decreased in INU or MET group. Moreover, IL-10 in ovary of INU or MET group was increased. Sequencing and analysis of gut microbiota showed that compared to MOD group, Bifidobacterium was increased, but Proteobacteria, Helicobacter and Parasutterella were decreased in INU group. Helicobacter was decreased in MET group. Correlation analysis showed that gut microbiota was correlated with inflammatory factors. Our results revealed that inulin and metformin alleviated PCOS via anti-inflammation and modulating gut microbiota, which may contribute to potential clinical therapy for the disease" - See inulin at Amazon.com.
  • Oral Carnitine Supplementation Reduces Body Weight and Insulin Resistance in Women With Polycystic Ovary Syndrome - Medscape, 8/10/16 - "Overall, 12 weeks of carnitine administration in PCOS women resulted in reductions in weight, BMI, WC and HC, and beneficial effects on glycaemic control; however, it did not affect lipid profiles or free testosterone" - See L-carnitine at Amazon.com.
  • Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial - Clin Endocrinol (Oxf). 2015 Dec 15 - "60 overweight patients diagnosed with PCOS were randomized to receive either 250 mg carnitine supplements (n=30) or placebo (n=30) for 12 weeks ... At the end of the 12 weeks, taking carnitine supplements resulted in a significant reduction in weight (-2.7±1.5 vs. +0.1±1.8 kg, P<0.001), BMI (-1.1±0.6 vs. +0.1±0.7 kg/m2 , P<0.001), waist circumference (WC) (-2.0±1.3 vs. -0.3±2.0 cm, P<0.001) and hip circumference (HC) (-2.5±1.5 vs. -0.3±1.8 cm, P<0.001) compared with placebo. In addition, compared with placebo, carnitine administration in women with PCOS led to a significant reduction in fasting plasma glucose (-0.38±0.36 vs. +0.11±0.97 mmol/L, P=0.01), serum insulin levels (-14.39±25.80 vs. +3.01±37.25 pmol/L, P=0.04), homeostasis model of assessment-insulin resistance (-0.61±1.03 vs. +0.11±1.43, P=0.04) and dehydroepiandrosterone sulfate (-3.64±7.00 vs. -0.59±3.20 μmol/L, P=0.03)" - See L-carnitine at Amazon.com.
  • Chromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial - Ann Nutr Metab. 2015 Jul 31 - "randomized to receive 200 µg chromium picolinate supplements (n = 32) or placebo (n = 32) for 8 weeks ... Chromium supplementation in women with PCOS resulted in significant decreases in serum insulin levels (-3.6 ± 7.4 vs. +3.6 ± 6.2 µIU/ml, p < 0.001), homeostasis model of assessment-insulin resistance (HOMA-IR; -0.8 ± 1.6 vs. +0.9 ± 1.5, p < 0.001), homeostatic model assessment-beta cell function (HOMA-B; -15.5 ± 32.3 vs. +13.6 ± 23.1, p < 0.001), and a significant increase in quantitative insulin sensitivity check index (QUICKI) score (+0.02 ± 0.03 vs. -0.008 ± 0.02, p = 0.001) compared with the placebo. In addition, a trend toward a significant effect of chromium supplementation on decreasing serum triglycerides (-12.4 ± 74.4 vs. +15.2 ± 32.4 mg/dl, p = 0.05), very low-density lipoprotein-cholesterol (-2.5 ± 14.9 vs. +3.0 ± 6.5 mg/dl, p = 0.05), and cholesterol concentrations (-8.6 ± 21.9 vs. +0.7 ± 22.4 mg/dl, p = 0.09) was seen" - See chromium supplements at Amazon.com.
  • Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial - Clin Endocrinol (Oxf). 2014 Dec 16 - "After 8 weeks of intervention, subjects who received selenium supplements had significantly decreased serum insulin levels (-29.83±47.29 vs. +9.07±77.12 pmol/L, P=0.013), homeostasis model of assessment-insulin resistance (HOMA-IR) (-1.15±1.81 vs. +0.42±3.09, P=0.011), homeostatic model assessment-Beta cell function (HOMA-B) (-19.06±30.95 vs. +4.55±47.99, P=0.017) and increased quantitative insulin sensitivity check index (QUICKI) (+0.03±0.04 vs. +0.0009±0.05, P=0.032) compared with placebo. In addition, supplementation with selenium resulted in a significant reduction in serum triglycerides (-0.14±0.55 vs. +0.11±0.30 mmol/L, P=0.025) and VLDL-C concentrations (-0.03±0.11 vs. +0.02±0.06 mmol/L, P=0.025) compared with placebo" - See se-methyl l-selenocysteine at Amazon.com.
  • Resveratrol and desferoxamine protect human oxLDL-treated granulosa cell subtypes from degeneration - J Clin Endocrinol Metab. 2013 Oct 29 - "Obese women suffer from anovulation and infertility, which are driven by oxidative stress caused by increased levels of lipid peroxides and circulating oxidised low-density lipoprotein (oxLDL). OxLDL binds to lectin-like oxLDL receptor 1 (LOX-1), CD36, and toll-like receptor 4 (TLR4) and causes cell death in human granulosa cells (GCs) ... To reveal whether treatment with antioxidants: resveratrol (RES) and/or desferoxamine (DFO) protect GCs from oxLDL-induced damage ... Granulosa cell cultures were treated with oxLDL alone or with resveratrol (RES) or desferoxamine (DFO) under serum-free conditions for up to 36 h ... Different subtypes of human GCs exposed to RES or DFO were protected as evidenced by lack of cell death, enhanced mitosis, reduced expression of LOX-1, TLR4, CD36, and Hsp-60, induction of protective autophagy, and reduction of oxidative stress markers. Importantly, RES could restore steroid-biosynthesis in cytokeratin-positive GCs which exhibited significant induction of steroidogenic acute regulatory protein ... RES and DFO exert a protective effect on human GCs. Thus, RES and DFO may help improving the treatment of obese women or PCOS patients undergoing IVF-therapy" - See resveratrol products at Amazon.com.
  • Omega-3 Fatty Acids Improve Glucose Metabolism without Effects on Obesity Values and Serum Visfatin Levels in Women with Polycystic Ovary Syndrome - J Am Coll Nutr. 2012 Oct;31(5):361-8 - "controlled clinical trial was conducted on 61 women who were diagnosed with PCOS, had a body mass index (BMI) between 25 and 40 kg/m(2), and were from 20-35 years old. Thirty of the subjects had taken four 1-g omega-3 fatty acids capsules per day, providing 1200 mg n-3 long chain polyunsaturated fatty acids (n-3 LC PUFA), and 31 were given a placebo over 8 weeks ... Omega-3 fatty acids significantly decreased glucose (by 11.4%, p < 0.001), insulin (by 8.4%, p < 0.05), and homeostatic model assessment for insulin resistance (by 21.8%, p < 0.001) compared with placebo" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Acupuncture May Bring Relief For Common Condition In Women, Study Suggests - Science Daily, 8/25/09
  • Omega-3 fatty acid supplementation decreases liver fat content in Polycystic Ovarian Syndrome: a randomised controlled trial employing proton magnetic resonance spectroscopy - J Clin Endocrinol Metab. 2009 Jul 21 - "Omega-3 fatty acid supplementation has a beneficial effect on liver fat content and other cardiovascular risk factors in women with PCOS, including those with hepatic steatosis" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • For Women With Polycystic Ovarian Syndrome, Acupuncture And Exercise May Bring Relief, Reduce Risks - Science Daily, 6/29/09
  • Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome - Fertil Steril. 2008 Oct 16 - "Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS"
  • Are There Natural Treatments for Polycystic Ovarian Syndrome? - Dr. Weil, 5/8/08
  • Novel Fiber Limits Sugar Absorption - Life Extension Magazine, 9/04 - "A common cause of obesity in women is called polycystic ovary syndrome, which is caused by having high blood levels of insulin. Metformin helps women with polycystic ovary syndrome to lose weight"
  • Cutting Calories Alone Eases PCOS - WebMD, 1/23/03
  • N-Acetyl Cysteine Improves Insulin Resistance in Women with Polycystic Ovary Syndrome - New Hope Natural Media, 12/12/02 - "PCOS ... affects up to 10% of all women of reproductive age ... characterized by enlargement of the ovaries, irregular menstrual cycle, failure to ovulate, obesity, high levels of insulin in the blood and insulin resistance, excessive hair growth (due to increased testosterone) and infertility. More than 50% of all women with PCOS have high insulin levels, which may be a risk factor for diabetes, high blood pressure, blood clots and heart disease ... Women with high initial insulin levels who took NAC had a significant reduction in insulin levels following the glucose tolerance test and also showed improved insulin sensitivity"

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