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Home > Health Conditions > Heartburn


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  • Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany - Drugs Aging 2023 May 13 - "Our large study supports existing evidence that PPI use is related to an increased risk of dementia."
  • Cutting Dietary Simple Sugars May Relieve GERD Symptoms - Science Daily, 7/11/22 - "There was a significant effect of diet on the two primary outcomes, total esophageal acid exposure time, and total number of reflux episodes, as measured by 24-hour ambulatory pH monitoring. The change in total acid exposure time was significantly greater for the high total/low simple group compared with the high total/high simple group."
  • Berberine Alleviates Gastroesophageal Reflux-Induced Airway Hyperresponsiveness in a Transient Receptor Potential A1-Dependent Manner - Evid Based Complement Alternat Med 2022 May 9 - "gastroesophageal reflux-induced airway hyperresponsiveness (GERAHR) ... Berberine, especially at the middle dose tested (MB, 150 mg/kg), significantly improved lung function, suppressed inflammatory cell infiltration, and protected inflammation-driven tissue damage in the lung, trachea, esophagus, and nerve tissues in GERAHR guinea pigs. MB reduced the expression of TRPA1, SP, and tumor necrosis factor-alpha (TNF-α) in evaluated organs and tissues. Meanwhile, the MB-mediated protective effects were attenuated by simultaneous TRPA1 activation ... Mechanistically, berberine was found to suppress GERAHR-induced upregulation of TRPA1, SP, and TNF-α in many tissues. Our study has highlighted the potential therapeutic value of berberine for the treatment of GERAHR" - See berberine at Amazon.com.
  • Treating Reflux With Diet - NYT, 9/7/17 - "85 patients with an average age of 60 treated with the P.P.I.s Nexium and Dexilant, and 99 treated with alkaline water and the Mediterranean diet, a regimen low in meat and dairy, and rich in olive oil, fish, beans, fruits and vegetables ... In the P.P.I. group, 54 percent achieved a clinically significant six-point reduction on the index, compared with 63 percent for the diet cohort" - See alkaline water pitchers at Amazon.com.
  • Proton Pump Inhibitors and Hypomagnesemia in the General Population - Medscape, 12/14/15 - "PPI use was associated with increased risk of hypomagnesemia (n = 36; OR, 2.00; 95% CI, 1.36–2.93) compared to no use" - See magnesium supplements at Amazon.com.
  • The Association Between Vitamin B12 Deficiency and Long-Term Use of Acid Lowering Agents: A Systematic Review and Meta-Analysis - Intern Med J. 2015 Jan 13 - "Chronic use of ALAs is a risk factor for developing vitamin B12 deficiency. Judicious prescribing of ALAs and regular monitoring of vitamin B12 in patients who are inevitably on long-term ALA therapy are recommended" - See vitamin B12 at Amazon.com.
  • PPI and Diuretic Up Risk for Hypomagnesemia Hospitalization - Medscape, 9/30/14 - "Elderly patients taking proton-pump inhibitors (PPIs) were at a 43% increased risk of being hospitalized with hypomagnesemia ... When the investigators stratified patients according to diuretic use, they found that those patients receiving both a PPI and a diuretic had a 73% increased risk for hospitalization (95% CI, 1.11 - 2.70) compared with those receiving neither drug" - See magnesium supplements at Amazon.com.
  • Hypomagnesemia Induced by Proton Pump Inhibition - Medscape, 8/29/12 - "PPI-induced hypomagnesaemia (PPIH) ... Proper identification and treatment of PPIH therefore mainly rests on three pillars: First, serum magnesium monitoring on a regular basis. In event of existing hypomagnesaemia discontinuation of PPIs should result in a rapid normalisation, which may be supported by additional magnesium and calcium supplementation.[60] This step is crucial to exclude other causes of hypomagnesaemia. Second, regular determination of serum magnesium (and concomitant other electrolytes) should be done to monitor the course of recovery. This should be accompanied by urinary magnesium measurements to assure renal magnesium retention. Third, patients with PPIH have the chance to escape hypomagnesaemia by alternative acid suppressants. Therefore, switching to H2RA should be attempted.[45] In cases of insufficient relief from acid related complains under H2RA, tapered or intermittent regimes including PPIs might be helpful. Also here, urinary magnesium monitoring is of benefit as it declines prior to the serum magnesium as an early indication.[61] In most cases reviewed here, supplementation with electrolytes could be stopped after normal serum magnesium was obtained"
  • Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats - Med Sci Monit. 2011 Dec 22;18(1):BR9-15 - "L-alanine and L-glutamine exert a deleterious effect on the esophagitis, while L-arginine and glycine are highly protective" - See L-arginine products at Amazon.com and l-glycine products at iHerb.
  • Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model - Int J Cancer. 2008 Oct 20 - "oxidative stress subsequent to gastroesophageal reflux is an important driving force of esophageal adenocarcinoma (EAC) formation in the esophagogastroduodenal anastomosis (EGDA) rat model. This study investigated the possible tumor inhibitory effects of 2 antioxidants, alpha-tocopherol (389 and 778 ppm), N-acetylcysteine (NAC, 500 and 1,000 ppm), and their combination (389 and 500 ppm, respectively), as well as an antacid therapeutic agent, omeprazole (1,400 ppm) ... alpha-Tocopherol dose-dependently decreased the incidence of EAC (p = 0.03), with 778 ppm alpha-tocopherol reducing the incidence of EAC to 59% (16/27) in comparison with 84% (26/31) in the control group (p = 0.04). Supplementation of alpha-tocopherol also increased the serum concentration of alpha-tocopherol. NAC at 500 and 1,000 ppm did not significantly decrease EAC incidence; however, the combination of alpha-tocopherol 389 ppm and NAC 500 ppm significantly reduced the incidence of EAC to 55% (15/27) (p = 0.02). alpha-Tocopherol alone or in combination with NAC significantly reduced the number of infiltrating cells positively stained for 4-hydroxynonenal. Omeprazole showed only a slight nonsignificant inhibitory effect at the dose given"
  • What Quenches Heartburn? - Dr. Weil, 11/10/08
  • Putting Heartburn to Bed? - Dr. Weil, 10/14/04
  • Natural remedies can tame raging heartburn - Natural Food Merchandiser, 1/04
  • Vitamin E May Improve Omeprazole Treatment of Moderate to Severe Erosive Oesophagitis - Doctor's Guide, 11/11/03
  • Chewing Gum May Prevent Heartburn - WebMD, 5/22/03
  • Ask Dr. J - Dr. Janson, 4/02 - "Chewing a licorice extract, called deglycyrrhizinated licorice (DGL) can soothe the symptoms of heartburn by coating the mucosa"

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