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Anti-aging Research > Gotu Kola
Gotu Kola (Cola vera or Cola nitada or Centella asiatica)
Specific Recommendations:
News & Research:
- Gotu Kola - The Natural Pharmacist
Abstracts:
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An Eluate of the Medicinal
Plant Garcinia kola Displays Strong Antidiabetic and Neuroprotective Properties
in Streptozotocin-Induced Diabetic Mice - Evid Based Complement Alternat Med
2022 Mar 21 - "G. kola methanolic extract was
fractionated using increasingly polar solvents. Fractions were administered to
streptozotocin (STZ)-induced diabetic mice until marked motor signs developed in
diabetic controls ... Our results suggest that subfraction F5 of G. kola extract
prevented the development of motor signs and improved disease profile in an
STZ-induced mouse model of diabetic encephalopathy. Antidiabetic activity of β-lactam
molecules accounted at least partly for these effects" - See
Gotu Kola at Amazon.com.
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Variations in
Echogenicity in Carotid and Femoral Atherosclerotic Plaques with Pycnogenol + Centella
Asiatica Supplementation - Int J Angiol. 2017 Jun;26(2):95-101 -
"Supplementation with the combination Pycnogenol-CA
(centella asiatica) on the echogenicity of plaques was assessed at 6 months
... t 6 months, plasma free radicals were decreased with the supplements
(17.64%; p < 0.05; vs <2% in controls). The plaque stability index increased
from 11.22;2.3 to 22.4;1.1 (p < 0.05) with the supplements; no significant
changes were seen in controls. Plaque echogenicity (% of "whiter" component
in images) increased with supplementation from 16.7;1.7% to 34.2;2%
(p < 0.05); no variations were observed in controls. The maximum plaque
height decreased (p < 0.05) with the supplements. No significant variations
were observed in controls. Plaque length was decreased (p < 0.05) in the
supplement group with no changes in controls. The number of plaques
(carotid, femoral bifurcations) decreased with supplementation; no
significant changes were observed in controls" - See
Pycnogenol at Amazon.com
and centella asiatica (Gotu Kola) at
Amazon.com.
- Effectiveness of
Gotu Kola Extract 750 mg and 1000 mg Compared with Folic Acid 3 mg in
Improving Vascular Cognitive Impairment after Stroke - Evid Based
Complement Alternat Med. 2016;2016:2795915 - "17
subjects were treated with 1000 mg/day of gotu kola extract, 17 subjects
treated with 750 mg/day of gotu kola extract, and 14 subjects treated with
3 mg/day of folic acid for 6 weeks. A Montreal Cognitive
Assessment-Indonesian version (MoCA-Ina) was conducted at the beginning of
treatment and after 6 weeks of therapy. It was found that all trials
effectively improved poststroke VCI based on MoCA-Ina scores over the course
of the study. There is no significant difference in ΔMoCA-Ina (score at the
6th week of treatment - score at the beginning) mean score among the three
groups, indicating that gotu kola is as effective as folic acid in improving
poststroke VCI. Gotu kola was shown to be more effective than folic acid in
improving memory domain. This study suggested that gotu kola extract is
effective in improving cognitive function after stroke"
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A new
herbal combination, Etana, for enhancing erectile function: an efficacy and
safety study in animals - Int J Impot Res. 2009 Jun 4 -
"a new herbal combination called Etana that is
composed of five herbal extracts including Panax quinquelotius (Ginseng),
Eurycoma longifolia (Tongkat Ali), Epimedium grandiflorum (Horny goat weed),
Centella asiatica (Gotu Kola) and flower pollen extracts. Most of the
above-mentioned extracts have a long historical and traditional use for
erectile dysfunction (ED) ... penile erection index (PEI) ... At a 7.5 mg
kg(-1) single dose, the percentage of responding rats was 53+/-7 with a PEI
of 337+/-72 compared with 17+/-6 with a PEI of 30+/-10 for control animals.
This PEI was significantly (P<0.001) higher than each single component and
than the sum of any two herbal components of Etana. When compared with
sildenafil citrate, Etana induced more pronounced PEI than 0.36 mg kg(-1),
but similar to 0.71 mg kg(-1) of sildenafil. Furthermore, full acute and
sub-acute toxicity studies showed no toxic effects of Etana. In conclusion,
this study describes a new and safe combination of herbal components that
enhance erectile function in male rats"
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