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  • Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway - Biochem Biophys Res Commun 2022 Nov 9 - "Fatigue, a most commonly sub-health condition, may cause people more susceptible to many diseases. Cordycepin, a principal active ingredient from Cordyceps militaris, exerts various pharmacological activities including anti-diabetes, anti-inflammatory, immunomodulatory and antioxidant effects. However, the anti-fatigue effect of cordycepin and specific mechanism remained unclear. This study aimed to investigate the beneficial effect of cordycepin on physical fatigue and elucidate the potential mechanism. 20 mg/kg, 40 mg/kg of cordycepin and 500 mg/kg taurine were respectively treated to mice for 28 days before weight-loaded swimming test. The results revealed that cordycepin significantly prolonged the weight-loaded swimming time of mice. Meanwhile, cordycepin decreased the levels of lactic acid, blood uric nitrogen, and malondialdehyde, and increased the contents of superoxide dismutase, glutathione, nicotinamide adenine dinucleotide phosphate, hepatic glycogen, muscle glycogen and ATP. The metabolomic study by GC-MS showed that eight biomarkers were found in livers, including L-lactic acid, L-asparagine, 3-phosphoglyceric acid, inosine, D-galactose, L-tyrosine, glyceric acid and L-threonine. There were seven biomarkers in gastrocnemius, including D-ribose-5-phosphate, acetic acid, propionic acid, butyric acid, palmitic acid, oxaloacetic acid and citric acid. The results of metabolomics indicated that cordycepin might relieve fatigue by regulating energy metabolism and pentose phosphate pathway. Furthermore, we found cordycepin significantly enhanced the protein levels of TIGAR, SIRT1, PGC-1α, NRF1 and TFAM in gastrocnemius of weight-loaded swimming mice. Taken together, the present study demonstrated that cordycepin possessed an anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway. Our study indicated that cordycepin may be a potentially efficient candidate for fatigue" - See Cordyceps militaris at Amazon.com.
  • Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study - Nutrients 2022 Feb 11 - "Deteriorating sleep quality and physical or mental fatigue in older adults leads to decreased quality of life and increased mortality rates. This study investigated the effects of the time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults ... NMN (250 mg) or placebo was administered once a day for 12 weeks. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. Fatigue was evaluated using the "Jikaku-sho shirabe" questionnaire. Grip strength, 5-times sit-to-stand (5-STS), timed up and go, and 5-m habitual walk were evaluated to assess the physical performance. Significant interactions were observed between 5-STS and drowsiness. 5-STS of all groups on post-intervention and drowsiness of the NMN_PM and Placebo_PM groups on mid- and post-intervention showed significant improvement compared with those in pre-intervention. The NMN_PM group demonstrated the largest effect size for 5-STS (d = 0.72) and drowsiness (d = 0.64). Overall, NMN intake in the afternoon effectively improved lower limb function and reduced drowsiness in older adults. These findings suggest the potential of NMN in preventing loss of physical performance and improving fatigue in older adults" - See NMN at Amazon.com.
    • NMN vs NR – 1 Huge Difference | Dr David Sinclair & Dr Andrew Huberman Interview Clips - YouTube - Dr. Sinclair, who had done significant research on NMN, claims MNM is better than the much more expensive NR. Dr. Sinclair makes sense. He confirms a lot of what I've read yet look how few views he gets compared to bullshit artists like Dr. Eric Berg or Dr. John Campbell. For some reason, whether it's politics or health, people prefer lies.
  • Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study - J Func Foods, Oct 2021 - "immunoglobulin A (sIgA), α-amylase (sAA) ... Based on the Bergen Insomnia Scale, Bacopa monnieri did not improve sleep patterns more than the placebo; however, it was associated with greater improvements in emotional wellbeing, general health, and pain-related symptoms. Bacopa monnieri was also associated with greater reductions in sIgA and sAA compared to the placebo" - [Nutra USA] - See Bacopa monnieri at Amazon.com and iHerb.
  • Mononucleosis-related fatigue: supplementary management with Robuvit® - Minerva Pediatr. 2018 Oct;70(5):425-429: - "After 4 weeks of treatment, a significant reduction in the rate of symptoms was evident in the Robuvit® group compared to the control group ... Supplementation with Robuvit® is safe, well tolerated, and effective in controlling oxidative stress levels and improving fatigue and other symptoms related to IM episodes during the convalescence period" - [Nutra USA] - See Robuvit® at Amazon.com.
  • Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit® - J Neurosurg Sci. 2018 Aug;62(4):423-42 - "Oxidative stress (OS) plays a substantial role in inflammatory and neurodegenerative diseases, causing cellular damage and mitochondrial dysfunction. OS also contributes to aging and severe neural disorders such as Alzheimer's and Parkinson's diseases ... They received three capsules of Robuvit® 100 mg per day, for 8 weeks ... Tolerability to the supplementation with Robuvit® was overall good, and no safety concerns were raised. Mood tests showed a significant general improvement in 13 out of 16 items of the BMIS (P<0.05) in the active treatment group. Oxidative stress levels decreased significantly with Robuvit® supplementation after 4 and 8 weeks. Fatigue and insomnia score were also significantly better in supplemented subjects (P<0.05). No changes were observed in controls" - [Nutra USA] - See Robuvit® at Amazon.com.
  • Grape seed proanthocyanidin extract supplementation affects exhaustive exercise-induced fatigue in mice - Food Nutr Res. 2018 Jun 6;62 - "These results proved that treatment of GSPE possessed the beneficial properties of anti-inflammatory, antioxidant, and mitochondrial protection to improve exhaustive exercise, which suggested that GSPE could be used as an effective functional food to delay fatigue" - [Nutra USA] - See grape seed extract at Amazon.com.
  • Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress - Minerva Med. 2018 Jun;109(3):211-217 - "This supplement registry study evaluated the effect of supplementation with Robuvit® on the burnout syndrome (BOS) of patients with significant fatigue and high oxidative stress. Robuvit® (French oak wood extract) is a standardized supplement, effective in treating chronic fatigue syndrome (CFS), post-traumatic stress disorder (PTSD) and convalescence ... Subjects followed a standard management (SM); one half of the subjects received 300 mg/day of Robuvit® for 4 weeks in addition to SM ... Robuvit® by controlling fatigue (the primary symptom) and oxidative stress, relieves the most important 'symptoms' associated with BOS. The effects are comparable in young surgeons not accustomed to stress, as well as in professionals in management positions who are used to control stress" - [Nutra USA] - See Robuvit® at Amazon.com.
  • Robuvit®: improvement of fatigue in medical convalescence - J Sports Med Phys Fitness. 2018 May;58(5):678-683 - "Weakness and heart rate were significantly reduced with Robuvit® in comparison with the controls (P<0.05) at 10 days and at 3 weeks; Attention and sleep patterns improved significantly at 3 weeks with Robuvit® (P<0.05) in comparison to controls. Recovery after efforts was normalized at 10 days in the supplement group, significantly better versus controls (P<0.05). O2 saturation increased significantly with Robuvit® at 10 days in comparison to controls (P<0.05). The alterations in working/concentration capacity were better improved with the supplement (P<0.05). Oxidative stress was significantly decreased (P<0.05) in comparison to controls. The improvement of health according to the Karrnofsky Scale was significantly more pronounced in the Robuvit® group (P<0.05). The supplement was well tolerated" - See Robuvit® at Amazon.com.
  • Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study - Nutrients. 2018 Feb 28;10(3) - "astaxanthin and sesamin (AS) ... Secondary outcomes included other subjective feelings, work efficiency, autonomic nerve activity, levels of an oxidative stress marker (plasma phosphatidylcholine hydroperoxide (PCOOH)) and safety. AS supplementation was associated with significantly improved recovery from mental fatigue compared with placebo. Increased PCOOH levels during mental and physical tasks were attenuated by AS supplementation. No differences between AS and placebo were detected in secondary outcomes, and no adverse effects of AS supplementation were observed. In conclusion, AS supplementation may be a candidate to promote recovery from mental fatigue which is experienced by many healthy people" - [Nutra USA] - See astaxanthin at Amazon.comand sesamin at Amazon.com.
  • Preclinical testing suggests some antioxidants may be effective in treating mitochondrial disease - Science Daily, 3/27/18 - "Mitochondrial disease results from malfunctions in mitochondria, the energy-generating "batteries" powering our cells. The disease is highly variable and may affect potentially any organ and body system ... In the current study, two compounds, the drug N-acetylcysteine (NAC) and vitamin E, showed compelling results in mitochondrial disease model animals. The compounds prolonged lifespan in mitochondrial complex I disease worms and protected complex I disease zebrafish from brain damage. NAC also improved survival in the cells obtained from a patient with mitochondrial complex I disease" - See n-acetyl cysteine at Amazon.com and vitamin E products at Amazon.com.
  • Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms - Neuropsychiatr Dis Treat. 2017; 13: 889–898 - "The majority of the outcome measures showed clear improvement over time. Several parameters had already improved after 1 week of treatment and continued to improve further up to the end of the study. The incidence of adverse events was low with 0.015 events per observation day" - [Nutra USA] - See Rhodiola rosea at Amazon.com.
  • Clinical Study Shows AstaReal(R) Astaxanthin Effective in Reducing both Mental and Physical Fatigue - yonhapnews.co.kr, 11/7/16 - "AstaReal® astaxanthin significantly reduced perceived symptoms of mental and physical fatigue compared to the placebo. These included improvements in clarity of thinking, concentration, motivation, and mood. Irritation and feeling of body heaviness were reduced. In the calculation test, an increase in errors observed in the placebo during the second half of the test was almost eliminated in the astaxanthin group. Supplementation with astaxanthin also significantly reduced salivary cortisol, a biomarker for stress" - [Nutra USA] - See astaxanthin at Amazon.com.
  • A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters - J Diet Suppl. 2016 May 10:1-15 - "Using a two-part approach in humans, the impact of theacrine (TeaCrine®, TC) was used to examine subjective dose-response, daily changes in cognitive and psychometric parameters, and changes in gas exchange and vital signs. ... visual analog scale (VAS) ... Energy, focus, and concentration increased from baseline values in both doses with no dose-response effect. VAS responses in the 200 mg for willingness to exercise, anxiety, motivation to train and libido increased across the measurement period while no such change was seen with the 400 mg dose. After consuming a single 200 mg dose, significant group × time interaction effects were seen for energy, fatigue, and concentration. No changes in resting heart rate, gas exchange, systemic hemodynamics or side effect profiles were noted" - See TeaCrine® at Amazon.com.
  • The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans - Br J Nutr. 2015 Sep 7 - "Subjective ratings of 'fatigue' were significantly lower across the entire 28 d in the resveratrol condition" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.
  • Energizing sick mitochondria with vitamin B3: Effective treatment for mitochondrial disease - Science Daily, 4/7/14 - "Vitamins B have recently been turned out to be potent modifiers of energy metabolism, especially the function of mitochondria. Vitamin B3, (niacin) has been found to delay the signs of aging in animal models ... Mitochondria power up all cells in our bodies, by generating fuel, ATP, for all cellular functions ... feeding mice with food supplemented with B3 form, nicotinamide riboside, delayed their mitochondrial myopathy" - Note: It seems like you could kill two birds with one stone by taking niacin to raise the good cholesterol.
    • What Is the Difference Between Niacin & Niacinamide? - LiveStrong.com - "Your body can convert niacin into niacinamide ... Niacin and niacinamide have identical function when used as vitamins ... their pharmacologic properties differ. For example, high doses of niacin can cause skin flushing. Niacinamide, however, does not have the same vasodialating, or blood-vessel widening, effects, that niacin has, so it does not lead to skin flushing" - Note:  You'll find contradictory information on the Internet but niacinamide will not raise HDL and niacin will.  See niacin at Amazon.com.
  • One Iron Pill a Day Keeps Fatigue Away? - Medscape, 8/20/13 - "evidence is growing that fatigue in non-anaemic, menstruating women with low ferritin can be influenced positively by iron supplementation ... the authors randomised 198 menstruating women with considerable fatigue (>6 on a 1–10 Likert scale), ferritin levels less than 50 μg/l and haemoglobin ≥12 g/dl to have 80 mg oral ferrous sulphate or placebo for 12 weeks ...A total of 47.7% of the patients in the iron group compared with 28.8% in the placebo group reported decreased fatigue. Quality of life, depression and anxiety were not affected ... As in all oral iron trials, darkening of stool leads to possible differentiation of verum from placebo, therefore, blinding was not totally assured; a substantial limitation considering the huge placebo effect on fatigue reported in studies using parenteral iron"
  • Effect of Magnolia officinalis and Phellodendron amurense (Relora(R)) on cortisol and psychological mood state in moderately stressed subjects - J Int Soc Sports Nutr. 2013 Aug 7;10(1):37 - "Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense) barks are medicinal plants commonly used as traditional remedies for reducing stress and anxiety ... assessed salivary cortisol exposure and psychological mood state in 56 subjects (35 men and 21 women) screened for moderate stress and supplemented with a standardized/patented MP combination (Relora(R), Next Pharmaceuticals) or Placebo for 4 weeks ... After 4 weeks of supplementation, salivary cortisol exposure was significantly (p<0.05) lower (-18%) in the Relora group compared to Placebo. Compared to Placebo, the Relora group had significantly better (p<0.05) mood state parameters, including lower indices of Overall Stress (-11%), Tension (-13%), Depression (-20%), Anger (-42%), Fatigue (-31%), and Confusion (-27%), and higher indices of Global Mood State (+11%) and Vigor (+18%)" - Note: The biggest affect was on anger (-42%).  - See Relora at Amazon.com.
  • Vitamins and minerals can boost energy and enhance mood - Science Daily, 7/16/13 - "In a series of studies she recently conducted in Canada, Kaplan found of the 97 adults with diagnosed mood disorders who kept a three-day food record, a higher intake of vitamins and minerals were significantly correlated with overall enhanced mental functioning ... Other vitamins that have been known to enhance mood, said C.J. Geiger, Ph.D., president of Geiger & Associates, LLC, and research associate professor in the division of nutrition at the University of Utah, include 5-Hydroxytryptophan (5 HTP), Vitamins B and D, as well as ginkgo biloba and Omega 3" - See 5-HTP products at Amazon.com and Ginkgo biloba at Amazon.com.
  • Significant link found between daytime sleepiness and vitamin D - Science Daily, 12/14/12 - "progressively higher levels of daytime sleepiness were correlated inversely with progressively lower levels of vitamin D" - See vitamin D at Amazon.com.
  • Obesity, depression found to be root causes of daytime sleepiness - Science Daily, 6/13/12 - "Three studies being presented June 13 at sleep 2012 conclude that obesity and depression are the two main culprits making us excessively sleepy while awake ... Insufficient sleep and obstructive sleep apnea also play a role; both have been linked to high blood pressure, heart disease, stroke, depression, diabetes, obesity and accidents"
  • Iron pills may help women beat fatigue - BBC News, 6/4/12 - "Prescribing iron supplements may help some women with fatigue even if they are not officially anaemic ... A severe shortage of iron is the most common cause of anaemia resulting in lethargy, weakness and feeling faint ... Nearly 200 women reporting fatigue, with no medical explanation, took part in the study. Half were given 80mg oral iron tablets every day, while half were given sugar pills ... iron supplementation for 12 weeks decreased fatigue [scores] by 50%" - See iron supplements at Amazon.com.
  • Surprising reasons you're tired all the time - MSNBC, 2/7/12 - "Anemia ... Diabetes ... Thyroid Disease ... Depression ... Rheumatoid Arthritis"
  • Top Tips for Fighting Fatigue - ABC News, 1/23/12 - it's a 5 minute video.
  • Pearls of wisdom from Lucy Liu - USATODAY.com, 1/17/12 - "Drink water; eat healthy; take vitamins; avoid the sun, exercise and stay clear of donuts (and other carbohydrates) which make you lethargic"
  • Boosting supply of key brain chemical reduces fatigue in mice - Science Daily, 12/10/10 - "Researchers at Vanderbilt University have "engineered" a mouse that can run on a treadmill twice as long as a normal mouse by increasing its supply of acetylcholine ... could lead to new treatments for neuromuscular disorders such as myasthenia gravis, which occurs when cholinergic nerve signals fail to reach the muscles ... The choline transporter is vital to the capacity for muscle contraction -- including the ability to breathe -- because it regulates the supply of choline, the precursor to acetylcholine. "We reasoned that giving more of this protein might enhance muscle function and reduce nerve-dependent fatigue,"" - See citicholine at Amazon.com.
  • Antioxidant Ingredient Proven To Relieve Stress - Science Daily, 9/14/09 - "The 35 people in our study who received capsules containing superoxide dismutase showed improvement in several signs and symptoms of perceived stress and fatigue" - See SOD supplements at Amazon.com.
  • Fatigue Predicts Mortality in Older Adults - J Am Geriatr Soc. 2008 Sep 22 - "Mortality rates at 10 years were 59% (123/210) for older adults with fatigue, versus 38% (106/282) for those without fatigue"
  • Rhodiola for What Ails You? - Dr. Weil, 5/15/08 - "A 2002 review in Herbalgram, the Journal of the American Botanical Council, reported that over the years, numerous studies of rhodiola in humans and animals have shown that it helps prevent fatigue, stress and the damaging effects of oxygen deprivation. Evidence also suggests that it has an antioxidant effect, enhances immune system function and can increase sexual energy ... A study published in 2007 in the Nordic Journal of Psychiatry showed that patients with mild-to-moderate depression who took a rhodiola extract reported fewer symptoms than those who took a placebo. And a study by researchers at the University of California at Irvine found that fruit flies that ate a diet supplemented with rhodiola lived an average of 10 percent longer than flies that didn't eat this herb" - See Rhodiola rosea at Amazon.com.
  • Low-intensity Exercise Reduces Fatigue Symptoms By 65 Percent, Study Finds - Science Daily, 2/28/08 - "Sedentary people who regularly complain of fatigue can increase their energy levels by 20 percent and decrease their fatigue by 65 percent by engaging in regular, low intensity exercise"
  • Energy-Boosting Supplements: Myths and Facts - ABC News, 2/22/06
  • Rev Up Your Energy - WebMD, 8/30/05
  • Energy for Sale - WebMD, 8/30/05
  • Foods to Fight Fatigue - WebMD
  • Drowsy Days May Signal Depression - WebMD, 8/12/05 - "After crunching the numbers, depression was the No. 1 risk factor for excessive daytime sleepiness. BMI came second. Typical sleep duration was third, followed by diabetes, smoking, and, finally, sleep apnea"
  • NADH, the supervitamin body and mind energizer - by James South MA - See nicotinamide adenine dinucleotide at Amazon.com.
  • Energizing the Elderly? - Dr. Weil, 3/24/05
  • Drowsy During the Day? - Dr. Weil, 7/8/04
  • Lack Energy? Maybe It's Your Magnesium Level - Science Daily, 5/10/04 - "inadequate magnesium is associated with a need for increased oxygen during exercise. They found that during moderate activity, those with low magnesium levels in muscle are likely to use more energy—and therefore to tire more quickly—than those with adequate levels"  - See iHerb or Vitacosticon magnesium products.
  • Energy to Burn - Men's Health/WebMD, 9/1/03
  • Iron Fights Fatigue in Women - Natural Foods Merchandiser, 9/03
  • Iron Supplements May Help Fatigued Women - Doctor's Guide, 5/22/03 - "Women who experience unexplained fatigue, but who are not anaemic may benefit from iron supplementation ...The level of fatigue after one month decreased by - 1.82/6.37 points (29%) in the iron group, compared with - 0.85/6.46 points (13%) in the placebo group ... the lower limit for serum ferritin concentration is controversial: iron stores in the bone marrow may serve as a better indicator of iron deficiency, they add. The lower reference limits for serum ferritin and haemoglobin concentrations have been considered too low for women and it has been suggested should be the same as for men"
  • Ribose Recovery - Nutrition Science News, 3/01
  • Bioenergetic Therapy for Aging - Life Extension Magazine, 2/01
  • Enada Reduces Chronic Fatigue Symptoms - Nutrition Science News, 8/99
  • Consult Your Pharmacist - The Many Faces of Fatigue - Medscape, 12/98
  • Coenzyme Q10: It May Just Be the Miracle Vitamin of the 1990s - The Nutrition Reporter