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Anti-aging Research > Dioscin
Dioscin
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Abstracts:
- Dioscin relieves
diabetic nephropathy via suppressing oxidative stress and apoptosis, and
improving mitochondrial quality and quantity control - Food Funct 2022
Mar 21 - "Dioscin is a steroidal saponin isolated
from various kinds of vegetables and herbs and possesses various biological
activities. In this study, the protective effect of dioscin on diabetic
nephropathy (DN) was explored. Dioscin and metformin (positive control) were
administered orally to diabetic rats daily for 8 weeks ... dioscin
effectively reduced blood glucose, pancreatic injury, renal function markers
and renal pathological changes in DN rat kidneys. Dioscin reduced O2- and
H2O2 levels, decreased MDA levels, enhanced antioxidant enzyme (SOD, CAT)
activities, and reduced inflammatory factor expressions. Moreover, NOX4
expression and the disorder of the mitochondrial respiratory chain were
reversed by dioscin. Furthermore, apoptosis mediated by the mitochondria and
ER stress was inhibited by dioscin through downregulating the expressions of
Bax, CytC, Apaf-1, caspase 9, p-PERK, p-EIF2α, IRE1, p-IRE1, XBP1s, ATF4,
p-CHOP and caspase 12. In addition, autophagy was enhanced by dioscin via an
AMPK-mTOR pathway. Mitophagy and mitochondrial fission/fusion belong to the
mitochondrial quality and quantity control process, which was improved by
dioscin via regulating Parkin, PINK1, DRP1, p-DRP1 and MFN2 expressions"
- See dioscin at Amazon.com.
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