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Home > Anti-aging Research > Creatine


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News & Research:

  • Creatine powers T cells' fight against cancer - Science Daily, 10/18/19 - "Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer ... Taken together, these findings suggest that killer T cells really need creatine to fight cancer ... Without it, they simply can't do their jobs effectively ... These new findings add killer T cells to the list of creatine-dependent cells, all of which utilize two distinct sources of power, much like hybrid cars. The first power source is a metabolic process that is similar to a fuel engine, converting nutrients like glucose, amino acids and lipids into ATP, the energy currency of cells. The secondary power source is creatine, which -- like a hybrid car's battery -- absorbs excess energy (in this case, ATP) and stores it to be released when fuel is in short supply to keep the cells working until more fuel can be burned" - See creatine at Amazon.com.
  • Dietary supplement boosts cognitive function in vegetarians - Science Daily, 4/8/19 - "Vegetarians who take the dietary supplement creatine may enjoy improved brain function ... Creatine is a chemical stored in the muscles and brain that helps build lean muscle ... One group took a daily creatine supplement for four weeks, and the other group did not. Before and after the trial, all participants took the ImPACT test, a widely used standardized measure of neurocognitive function. The vegetarian supplement group scored higher on the ImPACT test than the group that ate 10 or more servings of meat, poultry or seafood per week. "Meat eaters did not show any significant improvement of cognition following supplementation because [their] creatine levels were already elevated [from their diet],"" - See creatine at Amazon.com.
  • Creatine Increased Muscle Mass, Not Strength, in Patients With RA - Medscape, 6/8/16 - "Despite the increase in muscle mass, creatine supplementation did not differ from placebo in effect on isometric knee extensor strength, handgrip strength, or objectively assessed physical function" - Note:  If they ever do a study on it I'm betting they find the same problem with growth hormone.
  • High-Dose Creatine Promising in Prodromal Huntington's - Medscape, 3/14/14 - "Creatine helps maintain intracellular energy levels and so may prevent or impede the neurodegenerative process. Past studies have reported that reduced energy stores play a role in neuronal loss ... The drug or placebo came in packets, each with of 5 g of powder that could be added to foods such as yogurt or apple juice. Participants could take the maximum tolerated dose of the drug (30 g) daily. The creatine was pharmaceutical grade ... Interestingly, more carriers (9 of 10) dropped out of the study during the placebo-controlled phase, 7 of whom knew their genetic status (2 had been assigned to placebo) ... That so many carriers dropped out of the study was "completely counterintuitive," said Dr. Rosas. "You come in with this notion that if you know what your risk ... the rate of cortical thinning in several regions, including portions of precentral, superior and middle-temporal, superior and middle frontal precuneus, posterior parietal and occipital was significantly slower in the carriers taking creatine compared with the carriers receiving placebo"
  • Huntington disease prevention trial shows creatine safe, slows progression - Science Daily, 2/8/14 - "Among the ways that the mutated form of the huntingtin protein damages brain cells is by interfering with cellular energy production, leading to a depletion of ATP, the molecule that powers most biological processes. Known to help restore ATP and maintain cellular energy, creatine is being investigated to treat a number of neurological conditions -- including Parkinson disease, amyotrophic lateral sclerosis and spinal cord injury. Studies in mouse models of HD showed that creatine raises brain ATP levels and protects against neurodegeneration ... In participants who carried the HD mutation, the MRI scans taken at the outset of the trial had revealed significant atrophy in regions of the cerebral cortex and basal ganglia known to be affected by the disease. Followup MRI scans at six months showed a slower rate of atrophy in participants taking creatine compared to those on placebo. At the end of the second phase, the rate of brain atrophy had also slowed in presymptomatic participants that started taking creatine after 6 months on placebo"
  • Outmuscling major depression with creatine - Science Daily, 8/7/12 - "women with major depressive disorder (MDD) who augmented their daily antidepressant with 5 grams of creatine responded twice as fast and experienced remission of the illness at twice the rate of women who took the antidepressant alone ... Creatine is an amino acid made in the human liver, kidneys, and pancreas. It also is found in meat and fish. Inside the body it is converted into phosphocreatine and stored in muscle. During high-intensity exercise, phosphocreatine is converted into ATP, an important energy source for cells. For this reason, creatine has become a popular supplement among bodybuilders and athletes who are trying to add muscle mass or improve athletic ability ... The group that received creatine showed significantly higher improvement rates on the HDRS at two and four weeks (32 percent and 68 percent) compared to the placebo group (3.7 percent and 29 percent). At the end of eight weeks, half of those in the creatine group showed no signs of depression compared with one-quarter in the placebo group. There were no significant adverse side effects associated with creatine"
  • Creatine in Type 2 Diabetes - Medscape, 5/10/11 - "The patients were allocated to receive either creatine (CR) (5 g.d−1) or placebo (PL) ...This is the first randomized controlled trial to describe the beneficial effects of creatine supplementation on glycemic control in type 2 diabetic patients who underwent exercise training. As such, this supplement emerges as a valuable nonpharmacological approach for treating diabetes ... the mean reduction in HbA1c (−1.1%) was superior to that commonly seen with exercise training[25] or metformin[10] treatment alone, pointing out the therapeutic potential of this novel nutritional intervention"
  • Creatine may beef up brain function: Study - Nutra USA, 12/13/10 - "A battery of cognitive tests were performed by the women, both before and after the five days of study, with results showing that memory improved by about 40 percent in the vegetarians consuming the creatine supplements" - [Abstract]
  • Creatine In Addition To Exercise Enhances Strength In Older Adults - Science Daily, 10/2/07 - "The exercise training resulted in improvements of functional ability and strength in all participants, but those taking the CrM and CLA showed even greater gains in muscle endurance, an increase in fat-free mass and a decrease in the percentage of body fat"
  • Counting on Creatine? - Dr. Weil, 4/20/07
  • Creatine May Help Muscular Dystrophy - WebMD, 2/2/07
  • Creatine Supplement May Help People With Muscular Dystrophies - Science Daily, 1/31/07
  • Preliminary Study Shows Creatine and Minocycline May Warrant Further Study in Parkinson's Disease - Doctor's Guide, 2/24/06 - "Both creatine and minocycline appeared to modify the disease features as measured by a decline in the clinical signs of Parkinson's disease"
  • Compounds could slow Parkinson's disease - USA Today, 2/23/06
  • Effect of Creatine Supplementation on Training - Medscape, 1/3/06
  • Anti-Aging Benefits of Creatine - Life Extension Magazine, 4/05
  • The “Strength Supplement” that Improves Brain Power - Life Extension Magazine, 2/04
  • Creatine Supplements May Improve Muscle Strength in Young Children With DMD - Medscape, 10/23/03
  • Muscular Enhancement Supplements: Creatine, HMB, and Glutamine review - ConsumerLab.com, 9/25/03
  • Creatine: Not Just a Sports Nutrition Supplement - Life Extension Magazine, 9/03
  • Creatine May Boost Brain Performance - WebMD, 8/13/03 - "Forty-five vegetarian young adults received either 5 grams of creatine or a placebo powder for six weeks, followed by six weeks of no supplementation. The groups were then switched, and the placebo group received creatine for six weeks and vice versa ... The researchers found that creatine supplementation gave a "significant, measurable boost to brain power." In a memory test that asked participants to recall a string of numbers, people taking creatine recalled an average of 8.5 numbers vs. seven for people not taking the supplement"
  • Creatine Improves Muscle Function in Children with Muscular Dystrophy - Doctor's Guide, 7/24/03
  • Whey Protein Plus Creatine Boosts Strength, Muscle Mass - WebMD, 4/11/03
  • Athletes Believe The "Whey" To Greater Muscle Strength Is Through Training And Protein Supplements - Intelihealth, 4/10/03 - "supplementation with a100% whey isolate formulation and creatine produced greater muscle fiber growth increases that transferred into significant increases in functional strength" - See iHerb or Vitacosticon whey products.
  • Supplements That Increase The Effects Of Resistance Exercise Identified - Intelihealth, 3/19/03 - "of the more than 250 dietary products available, only HMB and creatine supplements have sufficient scientific evidence showing that lean body mass and strength gains accompanying resistance training are augmented with their use"
  • Creatine: More than a sports nutrition supplement - Life Extension Magazine, 3/03
  • Progress in Lou Gehrig's Disease - WebMD, 1/24/02 - "the antibiotic minocycline helps fight several brain diseases -- including ALS. Meanwhile, another group showed that the dietary supplement creatine also helps fight these kinds of diseases ... We combined the two and showed that together they are both more effective than either alone in the treatment of ALS"
  • Creatine Helps Maintain Alertness - Natural Foods Merchandiser, 11/02 - "They received either 8 g of creatine or a placebo for five days.  The participants were tested to determine mental fatigue before and after supplementation ... In the group taking the creatine supplements, performance was substantially better after five days of supplementation than before ... Oxygenation studies showed a complex pattern that is consistent with increased brain oxygen consumption following supplementation"
  • Supplements that Turn Up the Heat? - Dr. Weil, 8/15/02
  • FDA Grants Orphan Drug Status to Creatine for Amyotrophic Lateral Sclerosis - Doctor's Guide, 3/26/02 - "Creatine is a critical element in cellular energy production and modulation. It is the substrate of the creatine kinase system, which helps prolong cellular life and protect against cell injury and death ... We have seen, and continue to see, encouraging results among ALS patients, as measured by muscle strength and a decreased rate of deterioration. Additionally, creatine has a long history of safe use, and is well tolerated by patients in the study"
  • Studies Say Creatine Is OK - Intelihealth, 12/17/01 - "there were indications that users were less likely to feel they were overtrained and were less likely to report arm and shoulder fatigue, while nonusers were more likely to report feeling they were falling behind in their training ... All creatine is doing is letting you do a few extra reps in weight training, or cut a tenth of a second off your time ... You are looking at a 5 to 10 percent performance improvement ... Athletes on creatine might overtrain and might hurt themselves, but this would be the result of the athletes expecting to do more than they can ... If you want to go from training four days to training seven days, that could lead to overtraining, but that's not creatine's fault"
  • French Experts Link Creatine To Potential Cancer Risk - Intelihealth, 1/24/01
  • Creatine Use Spreads to High School Athletes, Long-Term Health Effects of Strength-Building Supplement Still Unknown - WebMD, 12/27/00
  • Young Athletes Try Creatine - Intelihealth, 12/11/00
  • Young athletes try creatine; adults hold their breath - CNN, 12/11/00
  • Study: Dietary supplement may protect against brain injury - CNN, 11/2/00
  • Creatine May Limit Brain Damage - WebMD, 11/2/00
  • Study Shows Dietary Supplement Helps Protect Against Brain Injury In Mice And Rats - Intelihealth, 11/2/00
  • Creatine Tests Well - Nutrition Science News, 10/00
  • Creatine Stands Its Ground - Nutrition Science News, 9/00
  • Creatine Boosts Effects of Weight Training - Nutrition Science News, 3/00 - "12 weeks of creatine supplementation had no side effects and significantly increased muscle, or fat-free, mass and maximal bench press strength compared with placebo. Muscle mass was also greater in the creatine group after the first week. The muscle gains seen at week 12 appeared to be due, in part, to increases in muscle fiber size"
  • Creatine May Help Athletes Perform - Intelihealth, 3/6/00
  • Using Creatine For More Than Muscles - Nutrition Science News, 10/99
  • Creatine: Is A Burst Of Energy Worth The Risk? - Dr. Dean, 8/2/99