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  • Ginsenoside Rg3 (Shenyi Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A Meta-Analysis and Systematic Review - Evid Based Complement Alternat Med. 2019 Dec 17 - "Ginsenoside Rg3 combined with chemotherapy can improve the clinical efficacy and alleviate treatment-induced side effects for digestive system cancer" - See ginseng at Amazon.com.
  • L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells - Nutr Cancer. 2018 Apr 26:1-13 - "Arsenic trioxide (As2O3) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the main reasons behind As2O3 toxicity ... Cotreatment of antioxidant vitamins with As2O3 resulted in a significant reversal of oxidative stress markers. Our findings substantiate the effect of antioxidant vitamins in protecting the hepatocytes from oxidative stress which may be attributed through Nrf2 (Nuclear factor erythroid 2-related factor 2) mediated upregulation of Bcl2 (B-cell lymphoma 2) expression" - See vitamin C products at Amazon.com and vitamin E products at Amazon.com.
  • Chemotherapy pain could be eased by jetlag drug, study suggests - Science Daily, 9/15/17 - "melatonin given prior to chemotherapy limited the damaging effect on nerve cells and the development of pain symptoms ... In this study, melatonin did not alleviate pain when CINP had already developed, suggesting that its potential benefits could be as prevention rather than cure ... melatonin treatment did not interfere with the beneficial anticancer effects of chemotherapy in human breast and ovarian cancer cells ... Findings also showed that melatonin reduced damage caused by chemotherapy to vital parts of nerve cells known as mitochondria" - See melatonin at Amazon.com.
  • Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial - Nutrients. 2017 Jul 19;9(7) - "health-related quality of life (HRQL) ... there were no differences in adverse events between placebo and red ginseng groups. In terms of HRQL, red ginseng was associated with improved emotional functioning and decreased symptoms of fatigue, nausea and vomiting, and dyspnea, reduced anxiety and interference affecting life and improved daytime somnolence" - See red ginseng extract at Amazon.com.
  • Nephroprotective Effects of Anthocyanin from the Fruits of Panax ginseng (GFA) on Cisplatin-Induced Acute Kidney Injury in Mice - Phytother Res. 2017 Jul 21 - "Cisplatin is an effective anticancer chemotherapeutic agent, but the use of cisplatin in the clinic is severely limited by side effects. Nephrotoxicity is a major factor that contributes to the side effects of cisplatin chemotherapy. The aim of this research was to survey the nephroprotective effects of anthocyanin from the fruits of Panax ginseng (GFA) in a murine model of cisplatin-induced acute kidney injury ... In conclusion, the findings from the present investigation demonstrate that GFA pre-administration can significantly prevent cisplatin-induced nephrotoxicity, which may be related to its antioxidant, anti-apoptotic and antiinflammatory effects" - See Panax ginseng at Amazon.com.
  • Nicotinamide riboside (vitamin B3) prevents nerve pain caused by cancer drugs - Science Daily, 2/23/17 - "Although chemotherapies have improved cancer survival rates, many of these drugs also cause debilitating side effects that decrease the quality of life of patients and survivors. In particular, many anti-cancer drugs cause chemotherapy-induced peripheral neuropathy (CIPN) -- nerve damage and pain ... Prophylactic treatment with daily doses of NR (200 mg/kg) for seven days before chemotherapy was started and continued for 24 days after the chemotherapy ended prevented the hypersensitivity to touch in the rats. This protective effect lasted for at least two weeks after the NR supplementation stopped" - See nicotinamide riboside at Amazon.com.
  • Fish Oil Supplementation Enhances Pulmonary Strength and Endurance in Women Undergoing Chemotherapy - Nutr Cancer. 2016 Jun 24:1-8 - "We investigated the effect of fish oil (FO) supplementation, at 4 g/day, on the respiratory performance and blood lipid profile of 32 patients with breast cancer at the beginning of chemotherapy. They were randomized into two groups: control (C) and FO supplemented (S) ... The S group showed a significant increase in the maximal inspiratory and expiratory pressure (P ≤ 0.05 vs. Day 0) and in the maximum voluntary ventilation (P ≤ 0.05). In the treadmill 6-min-walk test, the S group had a significant increase in the walked distance (P ≤ 0.05). Blood lactate concentration was significantly lower in the S group after 60 days, at rest, when compared to C (P ≤ 0.05). Plasma high-density lipoprotein (HDL) cholesterol concentration remained the same after 60 days of supplementation, while in the C group, it decreased significantly (P ≤ 0.05 Day 0 vs. Day 60). Triacylglycerol (TAG) plasma concentration in the S group was lower when compared to the C group (P ≤ 0.05 Day 60S vs. Day 60). Supplementation with FO caused improvement in the respiratory muscle strength and endurance, ameliorated functional performance, and kept TAG, HDL cholesterol, and lactate plasma concentration at normal levels" - See fish oil supplements at Amazon.com.
  • Melatonin Prevents Mitochondrial Damage Induced by Doxorubicin in Mouse Fibroblasts Through Ampk-Ppar Gamma-Dependent Mechanisms - Med Sci Monit. 2016 Feb 10;22:438-46 - "Melatonin given with doxorubicin succesfully countered apoptosis generated by doxorubicin alone, which points to its potential as a protective agent against cell death in doxorubicin chemotherapy. This also implies that patients should be receiving doxorubicin treatment when their physiological level of melatonin is at its highest, which is early in the morning" - See melatonin at Amazon.com.
  • The effect of melatonin on sleep and quality of life in patients with advanced breast cancer - Support Care Cancer. 2015 Aug 11 - "Thirty-two patients with metastatic breast cancer, receiving hormonal or trastuzumab therapy, took 5 mg of melatonin at bedtime for 2 months ... Bedtime melatonin was associated with a significant improvement in a marker of objective sleep quality, sleep fragmentation and quantity, subjective sleep, fatigue severity, global quality of life, and social and cognitive functioning scales. Morning clock gene expression was increased following bedtime melatonin intake" - See melatonin at Amazon.com.  I like the peppermint flavored by Source Naturals.
  • Fish Oil for Breast Cancer Patients Undergoing Chemotherapy - Medscape, 8/6/15 - "The supplementation of fish oil significantly (p < 0.01) increased superoxide dismutases, glutathione reductase and catalase activity in red blood cells as well as the total plasma antioxidant status in the patients. This approach of using omega-3 fatty acids as an adjuvant treatment for breast cancer may help oncologists to manage the side effects of ongoing chemotherapy by improving the antioxidant status in patients" - See fish oil supplements at Amazon.com.
  • Omega-3 fatty acids may help improve treatment, quality of life in cancer patients - Science Daily, 7/28/15 - "The study found evidence of activity in response and disease stabilization rates, reduction in liver metastasis volume, and improved quality of life scores in this group of patients"
  • Resveratrol, quercetin could provide new options for cancer therapy - Science Daily, 7/16/15 - "The co-administration of high levels of resveratrol and quercetin, in both in vitro and in vivo studies, shows that it significantly reduces the cardiac toxicity of Adriamycin," Alani said. "And these compounds have a synergistic effect that enhances the efficacy of the cancer drug, by sensitizing the cancer cells to the effects of the drug." - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com and Quercetin at Amazon.com.
  • Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in Mice - Evid Based Complement Alternat Med. 2015;2015:197459 - "BST204 was prepared by incubating crude ginseng extract with ginsenoside-β-glucosidase ... Treatment with BST204 significantly increased the running wheel activity and forced swimming time compared to the control group ... This result suggests that BST204 may improve chemotherapy-related fatigue and adverse toxic side effects" - See ginseng at Amazon.com.
  • Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis - J Physiol. 2015 Jan 13 - "A compromised cardiac function is often seen in elderly cancer patients receiving doxorubicin therapy ... resveratrol ameliorates doxorubicin-induced cardiotoxicity in the aged hearts through the restoration of SIRT1 activity to attenuate USP7-related catabolic/pro-apoptotic signalling" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.
  • Hesperidin protects testicular and spermatological damages induced by cisplatin in rats - Andrologia. 2014 Sep 13 - "this study clearly demonstrated that hesperidin has protective effects on cisplatin-induced reproductive system toxicity depending on its antioxidant properties. Thus, it is thought that hesperidin may be useful against cisplatin toxicity in patients with cancer in terms of reproductive system" - See hesperidin at Amazon.com.
  • Is Ginseng Effective for Cancer-Related Fatigue? - Medscape, 8/1/14 - "Barton and colleagues[1] performed a phase 3, multisite, double-blind, randomized trial evaluating the use of Wisconsin ginseng (P quinquefolius) (3% ginsenosides) 2000 mg daily vs placebo for 8 weeks in 364 patients with CRF. Fatigue was evaluated using the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) ... At 4 weeks, change from baseline MFSI-SF score in the ginseng group (n = 147) was 14.4 vs 8.2 in the placebo group (n = 153) (P = .07). At 8 weeks, the ginseng group (n = 138) had a change in score of 20 vs 10.3 in the placebo group (n = 133) (P = .003). Patients receiving active cancer therapy reported greater benefit than those who had completed treatment. Self-reported toxicities were similar between groups" - See ginseng at Amazon.com.
  • Alpha-Lipoic Acid Protects Against Cisplatin-Induced Ototoxicity via the Regulation of MAPKs and Proinflammatory Cytokines - Biochem Biophys Res Commun. 2014 May 2 - "these results indicate that the protective effects of ALA against cisplatin-induced ototoxicity are mediated via the regulation of MAPKs and proinflammatory cytokines" - See alpha lipoic acid products at Amazon.com.
  • Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity - Evid Based Complement Alternat Med. 2013;2013:846126 - "Cisplatin (CDDP) is a potent antitumor compound widely used with a notably side effect of nephrotoxicity inducing oxidative stress and apoptosis in kidneys ... These findings suggested that EGb's renoprotective effect might be mediated by not only its well-known antioxidant activity but also the anti-inflammatory activity" - See Ginkgo biloba at Amazon.com.
  • Fish oil, contained in eicosapentaenoic acid and docosahexaenoic acid, attenuates testicular and spermatological damage induced by cisplatin in rats - Andrologia. 2013 Dec 18 - "The aim of this study was to investigate the beneficial effects of the fish oil (FO) supplementation on oxidative stress, sperm characteristics and histological alterations in the male reproductive system of rats against cisplatin (CP) toxicity. The rats were divided randomly into 4 equal groups (control, FO, CP and FO + CP) ... The results showed that CP caused a significant oxidative damage via induction of lipid peroxidation and reduction in the antioxidant defence system potency in the testis tissue. In addition, sperm motility and sperm concentration significantly decreased but the abnormal sperm rate and histopathological testicular damage increased with CP treatment. On the other hand, FO treatment prevented oxidative, histopathological and spermatological effects of CP and reversed side effects of CP" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity - Evid Based Complement Alternat Med. 2013;2013:407839 - "Arsenic trioxide (As2O3) shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Unfortunately, limiting the application of this effective agent to APL patients is severe cardiotoxicity. Resveratrol, the natural food-derived polyphenolic compound, is well known for its antioxidant properties and protects the cardiovascular system. But the potential role of resveratrol against As2O3 in heart via nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) is unclear ... Our findings suggest coadministration with resveratrol, and As2O3 might provide a novel therapeutic strategy for APL" - See resveratrol products at Amazon.com.
  • Protective effect of Pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with Cyclophosphamide - Andrologia. 2013 Oct 11 - "Cancer treatment with cyclophosphamide (CP) may result in reproductive toxicity as one of its side effects. The pumpkin seed is a rich natural source of antioxidant ... Male adult Wistar rats were categorised into four groups. Group 1 served as control and received intraperitoneal (IP) injection of isotonic saline solution. Group 2 rats were treated with CP by IP injection in a single dose of 100 mg/kg body weight, only once. Group 3 and 4 received CP plus 300 and 600 mg/kg pumpkin seed extract respectively. Six weeks after treatment, sperm characteristics, biochemical parameters and histopathological changes were examined. Results showed that, sperm characteristics in CP-treated rats were significantly decreased ... pumpkin seed extract could improve the above-mentioned parameters remarkably in CP-treated rats. Our findings indicated that pumpkin seed extract might be used as protective agent against CP-induced reproductive toxicity" - See pumpkin seed extracts at iHerb.
  • Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue - Medscape, 9/27/13 - "cancer-related fatigue (CRF) ... A multisite, double-blind trial randomized fatigued cancer survivors to 2000mg of American ginseng vs a placebo for 8 weeks ... Multidimensional Fatigue Symptom Inventory–Short Form (MFSI-SF) ... A statistically significant difference was seen at 8 weeks with a change score of 20 (SD = 27) for the ginseng group and 10.3 (SD = 26.1) for the placebo group (P = .003). Greater benefit was reported in patients receiving active cancer treatment vs those who had completed treatment. Toxicities per self-report and CTCAE grading did not differ statistically significantly between arms" - See ginseng at Amazon.com.
  • Celery, artichokes contain flavonoids that kill human pancreatic cancer cells - Science Daily, 8/15/13 - "Apigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results when we pre-treated cancer cells with apigenin for 24 hours, then applied the chemotherapeutic drug gemcitabine for 36 hours ... our study indicated that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs ... One of the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they're introduced at the same time ... In one of the cancer cell lines, the percentage of cells undergoing apoptosis went from 8.4 percent in cells that had not been treated with the flavonoid to 43.8 percent in cells that had been treated with a 50-micromolar dose. In this case, no chemotherapy drug had been added" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells - Phytother Res. 2013 Aug 13 - "Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association with the reduction in ikappaB level may be one of such potential mechanisms. It is known that curcumin inhibits the inducible activation of NFkappaB at least in part by sustaining ikappaB expression level ... We found that erlotinib and curcumin augmentatively reduced cell viability ... Furthermore, coadministration of erlotinib and/or curcumin augmentatively attenuated the growth of PC9 tumors in mice" - See curcumin products at Amazon.com.
  • Silibinin reverses drug resistance in human small-cell lung carcinoma cells - Cancer Lett. 2013 Jul 20 - "The possible synergistic relationship between silibinin and chemotherapy drugs was determined by exposure of VPA17 cells to 1:1 ratios of their respective IC50 values, with serial dilutions at 0.25-2.0 x IC50 and calculation of the combination index (CI). Silibinin and etoposide showed synergism (CI = 0.46 at ED50), as did silibinin and doxorubicin (CI = 0.24 at ED50). These data indicate that in SCLC, silibinin is pro-apoptotic, reverses MDR and acts synergistically with chemotherapy drugs. Silibinin, a non-toxic natural product may be useful in the treatment of drug-resistant SCLC" - See silymarin at Amazon.com.
  • Wisconsin Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind Trial, N07C2 - J Natl Cancer Inst. 2013 Jul 13 - "A multisite, double-blind trial randomized fatigued cancer survivors to 2000mg of American ginseng vs a placebo for 8 weeks ... Three hundred sixty-four participants were enrolled from 40 institutions ... Data support the benefit of American ginseng, 2000mg daily, on CRF over an 8-week period. There were no discernible toxicities associated with the treatment" - See ginseng at Amazon.com.
  • Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine - Lipids Health Dis. 2013 Mar 16;12(1):36 - "N-3's are promising chemo-sensitizing agents for the treatment of CLL. Selective enhancement of chemo-sensitivity of EHEB, JVM-2 and MEC-2 to drugs by n-3 that is not dependent on increased lipid peroxidation and ROS generation indicates alternative mechanisms by which n-3 enhances chemo-sensitivity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega-3 fatty acids in cancer - Curr Opin Clin Nutr Metab Care. 2013 Jan 7 - "Inflammation dictates tumour initiation, progression and growth. Omega-3 fatty acids exert anti-inflammatory effects, and therefore recent studies investigated their role in cancer prevention, in cancer cachexia treatment and in enhancement of antitumour therapies. Limited evidence suggests a role for omega-3 fatty acid supplementation in cancer prevention, but they have been shown to preserve muscle mass and function in cancer patients even during active treatment. During chemotherapy, omega-3 fatty acids may contribute to a reduced inflammatory response, but whether cancer treatment toxicity can be prevented remains to be assessed. Finally, small studies showed that omega-3 fatty acids increase response rate to chemotherapy" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients - Support Care Cancer. 2012 Dec 14 - "Hematological toxicity and oxidative stress are common in cancer patients ... Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement ... At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group ... Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Ginseng May Banish Cancer Fatigue, New Study Finds - ABC News, 6/4/12 - "Researchers gave 2,000 milligrams of pure ground American ginseng or a placebo pill to 340 patients being treated for cancer and cancer survivors who had finished their treatment. After four weeks, patients reported little change in their cancer-related fatigue. But after eight weeks, the patients taking ginseng reported feeling generally more energized than their sugar pill-popping peers. The response was particularly strong among patients who were currently undergoing cancer treatment ... Some studies have shown that ginseng decreases inflammation and the stress hormone cortisol, both of which may be contributing factors to cancer-related fatigue ... Extracts of ginseng that are alcohol based change a characteristic of the ginseng to be somewhat estrogenic ... Stay with very reputable companies" - See ginseng at Amazon.com.
  • Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients - Support Care Cancer. 2011 Aug 5 - "A total of 576 patients were included in final analysis (91% female, mean age = 53). Mixed model analyses demonstrated that all doses of ginger significantly reduced acute nausea severity compared to placebo on Day 1 of chemotherapy (p = 0.003). The largest reduction in nausea intensity occurred with 0.5 g and 1.0 g of ginger (p����= 0.017 and p = 0.036, respectively). Anticipatory nausea was a key factor in acute chemotherapy-induced nausea (p < 0.0001) ... Ginger supplementation at a daily dose of 0.5 g-1.0 g significantly aids in reduction of the severity of acute chemotherapy-induced nausea in adult cancer patients" - See ginger products at iHerb.
  • Fish oil fights weight loss due to chemotherapy - Science Daily, 2/28/11 - "supplementing the diet with fish oil may prevent muscle and weight loss that commonly occurs in cancer patients who undergo chemotherapy ... Researchers suspect that supplementing the diet with fish oil -- which contains omega-3 fatty acids such as eicosapentaenoic acid -- may help patients maintain or gain muscle ... Patients who did not take fish oil lost an average of 2.3 kilograms whereas patients receiving fish oil maintained their weight. Patients with the greatest increase in eicosapentaenoic acid concentration in the blood following fish oil supplementation had the greatest gains in muscle. Sixty-nine percent of patients in the fish oil group gained or maintained muscle mass. Comparatively, only 29 percent of patients in the standard care group maintained muscle mass, and overall, patients in this group lost 1 kilogram of muscle. No difference in total fat tissue was observed between the two groups" - Note: 2.3 kilograms equals 5.1 pounds.  See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy - J Clin Pharm Ther. 2011 Jan 4 - "VCE (vitamin C 500 mg tablet and vitamin E 400 mg gelatin capsule ... The untreated group showed significantly lower levels of antioxidant enzymes (P<0.001) and reduced glutathione (P<0.001), and more extensive lipid peroxidation (P<0.001) and DNA damage than healthy controls. Similar but less pronounced patterns were observed in the patients receiving chemotherapy alone. The group of patients receiving VCE supplementation had all the marker levels moving towards normal values. Activities of superoxide dismutase, catalase, glutathione-S-transferase and glutathione reductase, and the levels of reduced glutathione were significantly increased (P<0.01) while, the levels of malondialdehyde and DNA damage were significantly (P<0.01) reduced in the VCE supplemented group relative to those of patients receiving chemotherapy alone as well as relative to the pretreatment levels"
  • Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study - Cancer Epidemiol Biomarkers Prev. 2010 Dec 21 - "Antioxidants may protect normal cells from the oxidative damage that occurs during radiotherapy and certain chemotherapy regimens, however, the same mechanism could protect tumor cells and potentially reduce effectiveness of cancer treatments ... Vitamin use shortly after breast cancer diagnosis was associated with reduced mortality and recurrence risk, adjusted for multiple lifestyle factors, sociodemographics, and known clinical prognostic factors. Women who used antioxidants (vitamin E, vitamin C, multivitamins) had 18% reduced mortality risk (hazard ratio (HR) = 0.82, 95% confidence interval (CI): 0.65-1.02) and 22% reduced recurrence risk (HR = 0.78, 95% CI: 0.63-0.95). The inverse association was found regardless of whether vitamin use was concurrent or non-concurrent with chemotherapy, but was only present among patients who did not receive radiotherapy"
  • DHA omega-3 may improve chemotherapy outcomes: Study - Nutra USA, 2/10/10 - "Our data show for the first time that a dietary intervention targeted on DHA is a feasible approach that has potential to substantially increase survival in metastatic breast cancer patients treated with chemotherapy ... the overall survival of women was 22 months, and reached 34 months in women with the highest DHA levels in their blood" - [Abstract] - See Jarrow Max DHA at Amazon.com.
  • Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial - Br J Cancer. 2009 Dec 15;101(12):1978-85 - "The objective response rate was 44%. With a mean follow-up time of 31 months (range 2-96 months), the median TTP was 6 months. Median OS was 22 months and reached 34 months in the sub-population of patients (n = 12) with the highest plasma DHA incorporation. The most common grade 3 or 4 toxicity was neutropaenia (80%). CONCLUSION: DHA during chemotherapy was devoid of adverse side effects and can improve the outcome of chemotherapy when highly incorporated. DHA has a potential to specifically chemosensitise tumours" - See Jarrow Max DHA at Amazon.com.
  • Milk thistle herb protects cancer patients from chemotherapy-associated liver toxicity - Science Daily, 12/27/09 - "Fifty children with ALL were enrolled in the study and were randomized to receive milk thistle or placebo for 28 days. At the start of the study, all of the children had evidence of liver inflammation as measured by elevations in blood levels of the liver enzymes, aspartate amino transferase (AST) and amino alanine transferase (ALT). When the investigators performed liver function tests on the children at day 56 (28 days after receiving the herb or placebo), children receiving milk thistle had improvements in their liver enzymes compared with children receiving a placebo. Specifically, the group that took milk thistle had significantly lower levels of AST and a trend towards significantly lower levels of ALT. Taking milk thistle also seemed to help keep fewer patients from having to lower the dose of their medications: chemotherapy doses were reduced in 61 percent of the group receiving milk thistle, compared with 72 percent of the placebo group. In addition, milk thistle appeared to be safe for consumption" - See silymarin (milk thistle) products at iHerb.
  • Herb May Treat Chemotherapy Liver Damage - WebMD, 12/14/09 - "The youths who took milk thistle had significantly lower levels of AST and a trend toward significant lower levels of ALT, the researchers say ... Milk thistle also seemed to help keep fewer patients from having to lower the dose of their chemotherapy drugs ... Chemotherapy doses were reduced in 61% of those on milk thistle, compared to 72% in the placebo group. Milk thistle appeared to be safe for consumption, the researchers write" - See silymarin (milk thistle) products at iHerb.
  • Workout Fights Chemo Fatigue - WebMD, 10/13/09
  • Support For Adjunctive Vitamin C Treatment In Cancer - Science Daily, 3/5/09 - "Challem points out two main problems with the study: the oxidized form of vitamin C (dehydroascorbic acid) and not actual vitamin C (ascorbic acid) was used; and in the mouse experiments, the animals were given toxic doses of dehydroascorbic acid, a compound that is not used as a dietary supplement in humans ... This study and the subsequent headlines [it generated] were a grievous disservice to physicians and patients with cancer ... considerable positive research…has shown striking benefits from high-dose vitamin C (ascorbic acid) in cancer cells and animals—and in actual human beings"
  • Green Tea Blocks Benefits Of Cancer Drug - Science Daily, 2/3/09
  • Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer - Int J Colorectal Dis. 2008 Oct 2 - "Chemotherapy is associated with a significant increase in the risk of severe vitamin D deficiency. Patients with colorectal cancer, especially those receiving chemotherapy, should be considered for aggressive vitamin D replacement strategies" - See vitamin D at Amazon.com.
  • Vitamin C, Chemotherapy: Bad Combo? - WebMD, 10/1/08 - "What vitamin C does is protect the cancer cells from the chemotherapy mainly by protecting their mitochondria [the cell's power sources]"
  • Antioxidant Supplements May Lessen Benefit Of Radiation And Chemotherapy - Science Daily, 5/27/08
  • Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model - Cancer Lett. 2008 Mar 12 - "Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer" - curcumin products at Amazon.com.
  • Indole-3-carbinol as a chemopreventive and anti-cancer agent - Cancer Lett. 2008 Feb 29 - "Indole-3-carbinol and its metabolite 3,3'-diindoylmethane (DIM) target multiple aspects of cancer cell-cycle regulation and survival including Akt-NFkappaB signaling, caspase activation, cyclin-dependent kinase activities, estrogen metabolism, estrogen receptor signaling, endoplasmic reticulum stress, and BRCA gene expression. This broad spectrum of anti-tumor activities in conjunction with low toxicity underscores the translational value of indole-3-carbinol and its metabolites in cancer prevention/therapy. Furthermore, novel anti-tumor agents with overlapping underlying mechanisms have emerged via structural optimization of indole-3-carbinol and DIM, which may provide considerable therapeutic advantages over the parental compounds with respect to chemical stability and anti-tumor potency. Together, these agents might foster new strategies for cancer prevention and therapy" - See indole-3-carbinol at Amazon.com and diindolylmethane at Amazon.com.
  • beta-Sitosterol induces G(2)/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways - Cancer Lett. 2008 Feb 29 - "beta-Sitosterol (SITO) is a potentially valuable candidate for cancer chemotherapy ... results suggest that SITO induces endoreduplication by promoting spindle microtubule dynamics through the Bcl-2 and PI3K/Akt signaling pathways" - See beta sitosterol at Amazon.com.
  • Chemoprevention, Naturally: Findings On Plant-derived Cancer Medicines - Science Daily, 12/6/07 - "rats fed a diet containing Polyphenon E, a standardized green tea polyphenol preparation, are less than half as likely to develop colon cancer ... After 34 weeks, rats that received Polyphenon E developed 55 percent fewer tumors compared to the control rats that did not receive Polyphenon E. Moreover, the tumors were 45 percent smaller in rats treated with green tea extract" - See green tea extract at Amazon.com.
  • Is There an Anticancer Diet? - WebMD, 12/6/07 - "Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and cauliflower seem to reduce bladder cancer risk by about 40%"
  • Antioxidants may hamper cancer therapies - Nutra USA, 9/22/05 - "there are some indications that antioxidants can actually be harmful for patients being treated with chemotherapy or radiotherapy, since they may be unable to differentiate between normal cells and cancer cells. This may mean that treatment is rendered less effective"
  • Exercise Helps Recovery From Chemotherapy For Breast Cancer - Science Daily, 6/13/05
  • Chemotherapy Alone vs. Chemotherapy Plus High Dose Multiple Antioxidants in Patients with Advanced Non Small Cell Lung Cancer - J Am Coll Nutr. 2005 Feb;24(1):16-21 - "These results do not support the concern that antioxidants might protect cancer cells from the free radical damage induced by chemotherapy"
  • Green tea for a healthy prostate? - MSNBC, 1/21/05 - "phytochemicals called polyphenols attack growth factors and proteins, interrupting processes that increase the size of tumors, thus preventing them from spreading to other parts of the body ... green tea in mice with an aggressive form of cancer can decrease the spread or metastasis of prostate cancer to liver, bone and other sites ... the phytochemicals in green tea could inhibit the early stages of prostate cancer development"
  • Low antioxidant vitamin intakes are associated with increases in adverse effects of chemotherapy in children with acute lymphoblastic leukemia - Am J Clin Nutr. 2004 Jun;79(6):1029-36 - "Lower intakes of antioxidants are associated with increases in the adverse side effects of chemotherapy"
  • Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy - Gynecol Oncol. 2004 May;93(2):320-327 - "we conclude that there are beneficial effects caused by ingesting selenium, as a supportive element in chemotherapy" - See iHerb selenium products.
  • High-folate diets and breast cancer survival in a prospective cohort study - Nutr Cancer 2002;44(2):139-44 - "women with total folate intake in the highest tertile had a mortality risk ratio of 0.88 (95% confidence interval = 0.44-1.76) compared with cases in the lowest tertile of folate. These findings, although preliminary, afford some reassurance that folate supplementation is unlikely to have a significant adverse effect on survival after chemotherapy for breast cancer"
  • In Praise of Spirulina - CancerDecisions.com, 12/12/02 - "Spirulina also shows potential for decreasing the adverse effects of both chemotherapy and radiation"
  • Is it Safe to Use Antioxidant Supplements with Chemotherapy? - New Hope Natural Media, 10/10/02 - "A new clinical trial published in the Journal of Clinical Oncology (2002;20:3478–83) provides the clearest evidence to date that taking antioxidant supplements does not interfere with the efficacy of cancer chemotherapy"
  • St. John's Wort and Chemo Don't Mix - WebMD, 8/20/02 - "Taking St. John's wort during chemotherapy could jeopardize the effectiveness of cancer treatment"
  • Sunlight, A Cancer Protector In The Guise Of A Villain? - Intelihealth, 8/6/02 - "Their theory was that vitamin D, which the skin produces when exposed to sunshine, somehow prevents the growth of malignant cells ... researchers are looking into vitamin D as a possible remedy. Clinical trials in people are now under way, testing whether the vitamin or similar compounds can treat tumors or bolster chemotherapy"
  • Three percent dietary fish oil concentrate increased efficacy of doxorubicin against mda-mb 231 breast cancer xenografts - Clin Cancer Res 2001 Jul;7(7):2041-9 - "a small amount of FOC increased the effectiveness of DOX but did not increase the toxicity of DOX to the host mouse. These positive results justify clinical testing of FOC in conjunction with cancer chemotherapy"

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